CN100593970C - Bactericide agent composition containing polyoxin having synergistic interaction and uses thereof - Google Patents
Bactericide agent composition containing polyoxin having synergistic interaction and uses thereof Download PDFInfo
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- CN100593970C CN100593970C CN200810017312A CN200810017312A CN100593970C CN 100593970 C CN100593970 C CN 100593970C CN 200810017312 A CN200810017312 A CN 200810017312A CN 200810017312 A CN200810017312 A CN 200810017312A CN 100593970 C CN100593970 C CN 100593970C
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- polyoxin
- germicide
- active component
- composition
- difenoconazole
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- 229930182764 Polyoxin Natural products 0.000 title claims abstract description 78
- YEBIHIICWDDQOL-YBHNRIQQSA-N polyoxin Polymers O[C@@H]1[C@H](O)[C@@H](C(C=O)N)O[C@H]1N1C(=O)NC(=O)C(C(O)=O)=C1 YEBIHIICWDDQOL-YBHNRIQQSA-N 0.000 title claims abstract description 78
- 239000000203 mixture Substances 0.000 title claims abstract description 48
- 239000003899 bactericide agent Substances 0.000 title description 6
- 230000009044 synergistic interaction Effects 0.000 title 1
- 239000005760 Difenoconazole Substances 0.000 claims abstract description 25
- BQYJATMQXGBDHF-UHFFFAOYSA-N difenoconazole Chemical compound O1C(C)COC1(C=1C(=CC(OC=2C=CC(Cl)=CC=2)=CC=1)Cl)CN1N=CN=C1 BQYJATMQXGBDHF-UHFFFAOYSA-N 0.000 claims abstract description 25
- RQDJADAKIFFEKQ-UHFFFAOYSA-N 4-(4-chlorophenyl)-2-phenyl-2-(1,2,4-triazol-1-ylmethyl)butanenitrile Chemical compound C1=CC(Cl)=CC=C1CCC(C=1C=CC=CC=1)(C#N)CN1N=CN=C1 RQDJADAKIFFEKQ-UHFFFAOYSA-N 0.000 claims abstract description 24
- 239000000126 substance Substances 0.000 claims abstract description 9
- 230000002195 synergetic effect Effects 0.000 claims description 26
- 150000003851 azoles Chemical class 0.000 claims description 24
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 23
- 230000003641 microbiacidal effect Effects 0.000 claims description 23
- 229940124561 microbicide Drugs 0.000 claims description 23
- 239000002855 microbicide agent Substances 0.000 claims description 23
- 239000000843 powder Substances 0.000 claims description 14
- 238000009736 wetting Methods 0.000 claims description 14
- 239000002270 dispersing agent Substances 0.000 claims description 10
- 239000000080 wetting agent Substances 0.000 claims description 10
- 239000004562 water dispersible granule Substances 0.000 claims description 8
- 230000000855 fungicidal effect Effects 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 6
- 239000000969 carrier Substances 0.000 claims description 4
- 239000000417 fungicide Substances 0.000 claims description 4
- 230000001186 cumulative effect Effects 0.000 claims description 2
- 244000141359 Malus pumila Species 0.000 abstract description 17
- 235000011430 Malus pumila Nutrition 0.000 abstract description 17
- 235000015103 Malus silvestris Nutrition 0.000 abstract description 17
- 201000010099 disease Diseases 0.000 abstract description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 7
- 239000000575 pesticide Substances 0.000 abstract description 6
- 230000003405 preventing effect Effects 0.000 abstract description 5
- 235000013311 vegetables Nutrition 0.000 abstract description 4
- 235000013399 edible fruits Nutrition 0.000 abstract description 3
- STMIIPIFODONDC-UHFFFAOYSA-N 2-(2,4-dichlorophenyl)-1-(1H-1,2,4-triazol-1-yl)hexan-2-ol Chemical compound C=1C=C(Cl)C=C(Cl)C=1C(O)(CCCC)CN1C=NC=N1 STMIIPIFODONDC-UHFFFAOYSA-N 0.000 abstract description 2
- 206010059866 Drug resistance Diseases 0.000 abstract description 2
- 239000005775 Fenbuconazole Substances 0.000 abstract description 2
- 240000007594 Oryza sativa Species 0.000 abstract description 2
- 235000007164 Oryza sativa Nutrition 0.000 abstract description 2
- 240000006365 Vitis vinifera Species 0.000 abstract description 2
- 235000014787 Vitis vinifera Nutrition 0.000 abstract description 2
- 241000607479 Yersinia pestis Species 0.000 abstract description 2
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- 235000009566 rice Nutrition 0.000 abstract description 2
- 230000002070 germicidal effect Effects 0.000 abstract 7
- 241000223600 Alternaria Species 0.000 abstract 1
- 240000001980 Cucurbita pepo Species 0.000 abstract 1
- 235000009852 Cucurbita pepo Nutrition 0.000 abstract 1
- 241000196324 Embryophyta Species 0.000 abstract 1
- 240000001987 Pyrus communis Species 0.000 abstract 1
- 235000014443 Pyrus communis Nutrition 0.000 abstract 1
- 230000000295 complement effect Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000035613 defoliation Effects 0.000 description 22
- 230000003449 preventive effect Effects 0.000 description 17
- 239000002994 raw material Substances 0.000 description 12
- 239000000047 product Substances 0.000 description 8
- 238000002360 preparation method Methods 0.000 description 7
- 239000007788 liquid Substances 0.000 description 6
- 238000005303 weighing Methods 0.000 description 6
- 230000000844 anti-bacterial effect Effects 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- -1 Sodium alkyl benzene Chemical class 0.000 description 4
- 239000004480 active ingredient Substances 0.000 description 4
- 229940077388 benzenesulfonate Drugs 0.000 description 4
- 239000000945 filler Substances 0.000 description 4
- 238000005469 granulation Methods 0.000 description 4
- 230000003179 granulation Effects 0.000 description 4
- 239000011734 sodium Substances 0.000 description 4
- 229910052708 sodium Inorganic materials 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 3
- 239000005995 Aluminium silicate Substances 0.000 description 2
- 150000004996 alkyl benzenes Chemical class 0.000 description 2
- 235000012211 aluminium silicate Nutrition 0.000 description 2
- 230000008485 antagonism Effects 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 239000007859 condensation product Substances 0.000 description 2
- NVVZQXQBYZPMLJ-UHFFFAOYSA-N formaldehyde;naphthalene-1-sulfonic acid Chemical compound O=C.C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 NVVZQXQBYZPMLJ-UHFFFAOYSA-N 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 2
- SNTWKPAKVQFCCF-UHFFFAOYSA-N 2,3-dihydro-1h-triazole Chemical compound N1NC=CN1 SNTWKPAKVQFCCF-UHFFFAOYSA-N 0.000 description 1
- PNWSHHILERSSLF-UHFFFAOYSA-N 4-methylbenzene-1,3-dicarboxylic acid Chemical compound CC1=CC=C(C(O)=O)C=C1C(O)=O PNWSHHILERSSLF-UHFFFAOYSA-N 0.000 description 1
- 241000235349 Ascomycota Species 0.000 description 1
- 241000221198 Basidiomycota Species 0.000 description 1
- 241000207199 Citrus Species 0.000 description 1
- 244000241257 Cucumis melo Species 0.000 description 1
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 206010034133 Pathogen resistance Diseases 0.000 description 1
- 241000220324 Pyrus Species 0.000 description 1
- 206010039509 Scab Diseases 0.000 description 1
- 229930182558 Sterol Natural products 0.000 description 1
- 241001454747 Streptomyces aureus Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 244000098338 Triticum aestivum Species 0.000 description 1
- 235000009754 Vitis X bourquina Nutrition 0.000 description 1
- 235000012333 Vitis X labruscana Nutrition 0.000 description 1
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000000862 absorption spectrum Methods 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 235000020971 citrus fruits Nutrition 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 230000017858 demethylation Effects 0.000 description 1
- 238000010520 demethylation reaction Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 230000008686 ergosterol biosynthesis Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 239000002917 insecticide Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 239000003595 mist Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 235000021017 pears Nutrition 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 239000002718 pyrimidine nucleoside Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a germicide pesticide composition, in particular to a germicide composition with polyoxin and synergized action which can prevent alternaria leaf spot that is difficult to prevent in agriculture, and application thereof. The germicide pesticide composition comprises an active component A which is polyoxin and an active component B which is composed of at least one of the following germicides: difenoconazole, fenbuconazole and hexaconazole. The germicide pesticide composition of the invention is applied to prevent various diseases relating to fruit trees (apple trees, pear trees, orange trees and grapevines), vegetables, gourd vegetables, crops, rice, etc. And the germicide pesticide composition is safe to plants, low in cost and effective in prevention. The tests show that the germicide composition of the invention has stable chemical property and obvious synergized action enabling preventing targets to have obvious synergized and complementary effects, can improve preventing effect and reduce the dosage of active component and delay generation of drug resistance of the pests, diminishes pollution to the environment and reduces the production cost with preventing effect above 70-92 percent; the preventing effect is 1.5 times of that in prior art.
Description
Technical field
The present invention relates to the agriculture chemicals fungicide composition, being specifically related to is that can prevent and treat spot defoliation that agricultural goes up difficult control a kind of contained microbicide compositions and the application thereof that polyoxin has synergistic function.
Background technology
Spot defoliation is a disease more common on a kind of crop, usually causes crushing disaster.Particularly spot defoliation is difficult to control, especially in zone, the north, and annual the generation.In some serious zone, the conventional pesticide composition uses separately and be difficult to control, and effect is very poor.
Go up the germ that produces resistance for control agricultural, a kind of way is to release the new component that new and existing kind do not have cross resistance.But the development cost height of new active ingredient, the construction cycle is long, and all produces the speed of resistance forever less than insect.Therefore, identical for mechanism of action, the composition of different cultivars is mixed, and is a kind of selection of the best.If reasonable proportioning is arranged, usually can produce synergistic effect.Make field control effect significantly be better than the effect of two kinds of single agent.Show the result of 1+1＞2.So far do not see the report of the bactericidal composition that polyoxin and Difenoconazole, RH-7592 or own azoles alcohol are formed.
Summary of the invention
The purpose of this invention is to provide a kind of in order to satisfy the needs that agricultural goes up production, make full use of two kinds of active components be mixed the synergistic effect that produced, improve preventive effect, reduce agricultural cost, and generation a kind of who delays disease drug resistance contained the microbicide compositions that polyoxin has synergistic function.
Another object of the present invention provides the application of microbicide compositions.
In order to overcome the deficiencies in the prior art, technical scheme of the present invention is to solve like this: a kind ofly contain the microbicide compositions that polyoxin has synergistic function, its special character is that active components A is a polyoxin in the described composition, active component B is made up of a kind of of following at least bactericide again in the described composition, and bactericide is meant Difenoconazole, RH-7592, own azoles alcohol.
Described a kind of microbicide compositions that polyoxin has synergistic function that contains, its special character are that the ratio of weight and number of two kinds of active components in the composition of active component polyoxin A and active component B combination is 1: 50～50: 1.
Described a kind of microbicide compositions that polyoxin has synergistic function that contains, its special character are that the ratio of weight and number of two kinds of active components in the composition of active component polyoxin A and active component B combination is 1: 40～40: 1.
Described a kind of microbicide compositions that polyoxin has synergistic function that contains, its special character are that the ratio of weight and number of two kinds of active components in the composition of active component polyoxin A and active component B combination is 1: 30～30: 1.
Described a kind of microbicide compositions that polyoxin has synergistic function that contains, its special character are that the ratio of weight and number cumulative amount of two kinds of active components in the composition of active component polyoxin A and active component B combination is between 1-60.
Described a kind of application that polyoxin has the microbicide compositions of synergistic function that contains, its special character are that active components A is mixed with into water dispersible granules and wetting powder with the agriculture chemicals fungicide composition that active component B forms with auxiliary material.
Described a kind of application that polyoxin has the microbicide compositions of synergistic function that contains, its special character is that said auxiliary material contains 8～20 dispersants, 4～10 wetting agents, 10～40 carriers.
Above-mentioned said polyoxin: be the metabolite that streptomyces aureus produces, belong to the broad-spectrum antibiotics series bactericidal agent, have interior preferably absorption.Be a kind of efficient, the safety pesticide of low toxicity non-environmental-pollution, owing to belong to biologic product, and simple the use, preventive effect is slow.
The English common name of polyoxin: polyoxin
Chemical name: peptide pyrimidine nucleoside.
Structural formula:
Molecular formula: C
17H
25N
5O
14Molecular weight: 568.30
Above-mentioned said Difenoconazole is to inhale wide-spectrum bactericide in a kind of, to diseases such as the leaf spot of various vegetables and fruit tree and scabs, better therapeutic effect is arranged.The English common name of Difenoconazole: difenoconazole, chemical name: 1-(2-[4-(4-chlorobenzene oxygen)-2-chlorphenyl]-the 4-methyl isophthalic acid, 3-dioxin-pentane-2-ylmethyl)-H-1,2, the 4-triazole.
Structural formula:
Molecular formula: C
19H
17C
12N
3O
3Molecular weight: 406.3
Above-mentioned said RH-7592 belongs to ergosterol biosynthesis inhibitor (EBI).Have protection concurrently, cure the disease and the interior absorption spectrum bactericide of killing action.The apple tree spot defoliation there is good control efficiency.The english common name of RH-7592: fenbuconazole, chemical name: 4-(4-chlorphenyl)-2-phenyl-2 (1H-1,2,4-triazol-1-yl methyl) butyronitrile.
Structural formula:
Above-mentioned said own azoles alcohol this product belongs to azoles fungicide, is sterol demethylation inhibitor, and fungi (especially Basidiomycetes and the Ascomycetes) disease that causes is had the protection and the eradicant action of broad spectrum activity.Spot defoliation on the effectively preventing and treating apple-tree.The english common name of own azoles alcohol: hexaconazole, chemical name: (RS)-2-(2,4 dichloro benzene base)-1-(1H-1,2,4-triazol-1-yl)-oneself-2-alcohol.
Structural formula:
After mixing, two kinds of fungicidal activity components show three kinds of type of action usually, i.e. synergistic effect, summation action and antagonism.The present invention adopts Sun Yunpei (SunY-P) method, by calculating co-toxicity coefficient, estimates and uses effect with.This is the evaluation criterion that those skilled in the art adopts usually in the interaction of estimating the fungicidal activity component.Co-toxicity coefficient obviously is synergistic effect greater than 100, and co-toxicity coefficient is significantly less than 100 and is antagonism, and co-toxicity coefficient=100 are summation action.
Computing formula:
The content (%) of B in the TI * mixture active ingredient of content (%)+B agent of A in the TI * mixture active ingredient of theoretical toxicity index (the ATI)=A agent of mixture
Be that the measurement result of apple tree spot defoliation sees Table 1 and table 2 and table 3 respectively below
Table 1 polyoxin+Difenoconazole is to the spot defoliation experimental data
| Handle | LC50(PPM) | Co-toxicity coefficient |
| Polyoxin 1+ Difenoconazole 50 | 12.01 | 425.31 |
| Polyoxin 15+ Difenoconazole 40 | 13.13 | 489.06 |
| Polyoxin 20+ Difenoconazole 30 | 10.21 | 386.48 |
| Polyoxin 35+ Difenoconazole 20 | 12.14 | 591.30 |
| Polyoxin 50+ Difenoconazole 1 | 9.87 | 687.49 |
| Polyoxin | 40.19 | |
| Difenoconazole | 60.01 |
Table 2 polyoxin+RH-7592 is to the spot defoliation experimental data
| Handle | LC50(PPM) | Co-toxicity coefficient |
| Polyoxin 1+ RH-7592 50 | 13.65 | 472.06 |
| Polyoxin 10+ RH-7592 45 | 15.26 | 352.46 |
| Polyoxin 30+ RH-7592 30 | 14.68 | 527.84 |
| Polyoxin 40+ RH-7592 15 | 13.67 | 687.94 |
| Polyoxin 50+ RH-7592 1 | 11.54 | 536.25 |
| Polyoxin | 30.21 | |
| RH-7592 | 55.89 |
Table 3 polyoxin+own azoles alcohol is to the spot defoliation experimental data
| Handle | LC50(PPM) | Co-toxicity coefficient |
| The own azoles alcohol 50 of polyoxin 1+ | 12.37 | 552.36 |
| The own azoles alcohol 45 of polyoxin 10+ | 14.32 | 580.37 |
| The own azoles alcohol 30 of polyoxin 20+ | 16.30 | 602.34 |
| The own azoles alcohol 25 of polyoxin 40+ | 11.24 | 689.25 |
| The own azoles alcohol 1 of polyoxin 50+ | 12.36 | 426.57 |
| Polyoxin | 46.89 | |
| Own azoles alcohol | 68.46 |
As can be seen from the table, polyoxin and Difenoconazole, RH-7592 or wherein any one combination of own azoles alcohol.The spot defoliation of difficult control on the agricultural there is clearly synergistic effect.
Said composition can be made water dispersible granules, wetting powder according to conventional method as required.
Wetting powder contains 1～60 active component usually, except solid inert carrier, contains said auxiliary material usually and contains 8～20 dispersants, 4～10 wetting agents, 10～40 carriers.Water dispersible granules is made 10～100 international standard sieve meshes usually, and (1.676～0.152mm) particles can be by extruding, dipping or the preparation of mist projection granulating method.Usually granule contains 0.5～75% active component, and is external except solid, inert, contains said auxiliary material usually and contains 8～20 dispersants, 4～10 wetting agents, 10～40 carriers.
Composition of the present invention is used in all kinds of diseases such as control fruit tree (apple, pears, citrus, grape), vegetables, melon, wheat class, paddy rice, to crop safety, cost is low, preventive effect good.Prove that after tested microbicide compositions chemical property of the present invention is stable, synergy is remarkable, and controlling object shows tangible synergy and complementation.Improved preventive effect, reduced the consumption of active ingredient, delayed the generation of pest resistance to insecticide, and reduced the pollution to environment, preventive effect is more than 1.5 times of prior art more than 70%～92%.
Embodiment
The invention will be further described below in conjunction with embodiment:
Embodiment 1
Prepare 60% polyoxin difenoconazole water dispersible granule 100kg
Polyoxin 50kg (weight ratio 50%)
Difenoconazole 10kg (weight ratio 10%)
Naphthalene sulfonate formaldehyde condensation products (dispersant) 10kg (weight ratio 10%)
Sodium alkyl benzene sulfonate (wetting agent) 5kg (weight ratio 5%)
White carbon (carrier) 25kg (weight ratio 25%)
The microbicide compositions that has synergistic effect by above-mentioned weight proportion weighing prepares raw material load weighted above-mentioned raw materials is fully mixed, and after the spray granulation granulation, promptly obtains 60% polyoxin difenoconazole water dispersible granule finished product.
2000～2500 times of liquid of the preparation of proportioning more than 83%, are better than single usefulness to the preventive effect of apple tree spot defoliation according to the above ratio.
Embodiment 2
Prepare the own azoles alcohol of 50% polyoxin wetting powder 100kg
Polyoxin 40kg (weight ratio 40%)
Own azoles alcohol 3kg (weight ratio 3%)
NNO (dispersant) 15kg (weight ratio 15%)
Sodium alkyl benzene sulfonate (wetting agent) 5kg (weight ratio 5%)
Kaolin (filler) 37kg (weight ratio 37%)
The microbicide compositions that has synergistic effect by above-mentioned weight proportion weighing prepares raw material load weighted above-mentioned raw materials is fully mixed, and after airslide disintegrating mill is pulverized, mixes again, promptly obtains the own azoles alcohol of 50% polyoxin wetting powder finished product.
1000～1500 times of liquid of the preparation of proportioning are being better than single usefulness to the preventive effect of apple tree spot defoliation more than 72% according to the above ratio.
7 days preventive effects (%) behind the 60% polyoxin Difenoconazole WG control apple tree spot defoliation medicine
| Handle | I | II | III | IV | On average |
| 2000 times | 88.21 | 88.26 | 87.15 | 89.62 | 88.31 |
| 2200 times | 84.37 | 85.69 | 84.82 | 87.31 | 85.55 |
| 2500 times | 81.84 | 84.01 | 83.28 | 85.88 | 83.75 |
| 800 times of 10% polyoxin WG | 59.61 | 58.81 | 56.78 | 60.24 | 58.86 |
| 2000 times of 10% Difenoconazole WG | 73.05 | 72.63 | 72.59 | 73.64 | 72.97 |
7 days preventive effects (%) behind the own azoles alcohol of the 50% polyoxin WP control apple tree spot defoliation medicine
| Handle | I | II | III | IV | On average |
| 1000 times | 87.22 | 87.19 | 88.05 | 89.05 | 87.88 |
| 1200 times | 73.84 | 76.44 | 78.61 | 76.54 | 76.36 |
| 1500 times | 70.08 | 71.28 | 72.25 | 75.24 | 72.21 |
| 800 times of 10% polyoxin WP | 54.26 | 50.07 | 56.78 | 52.37 | 53.37 |
| 2000 times of 5% own azoles alcohol SC | 63.77 | 65.34 | 68.06 | 67.42 | 66.14 |
Embodiment 3
Prepare 60% polyoxin RH-7592 wetting powder 100kg
Polyoxin 40kg (weight ratio 40%)
RH-7592 20kg (weight ratio 20%)
NNO (dispersant) 15kg (weight ratio 15%)
Alkyl benzene calcium sulfonate (wetting agent) 7kg (weight ratio 7%)
White carbon (filler) 18kg (weight ratio 18%)
The microbicide compositions that has synergistic effect by above-mentioned weight proportion weighing prepares raw material load weighted above-mentioned raw materials is fully mixed, and after airslide disintegrating mill is pulverized, mixes again, promptly obtains 60% polyoxin RH-7592 wetting powder finished product.
2000～2500 times of liquid of the preparation of proportioning more than 70%, are better than single usefulness to the preventive effect of apple tree spot defoliation according to the above ratio.
60% polyoxin RH-7592 wetting powder control apple tree spot defoliation preventive effect
Embodiment 4
Prepare 60% polyoxin difenoconazole water dispersible granule 100kg
Polyoxin 10kg (weight ratio 10%)
Difenoconazole 50kg (weight ratio 50%)
Naphthalene sulfonate formaldehyde condensation products (dispersant) 10kg (weight ratio 10%)
Sodium alkyl benzene sulfonate (wetting agent) 5kg (weight ratio 5%)
White carbon (carrier) 25kg (weight ratio 25%)
The microbicide compositions that has synergistic effect by above-mentioned weight proportion weighing prepares raw material load weighted above-mentioned raw materials is fully mixed, and after the spray granulation granulation, promptly obtains 60% polyoxin difenoconazole water dispersible granule finished product.
8000～10000 times of liquid of the preparation of proportioning more than 92%, are better than single usefulness to the preventive effect of apple tree spot defoliation according to the above ratio.
Embodiment 5
Prepare the own azoles alcohol of 50% polyoxin wetting powder 100kg
Polyoxin 3kg (weight ratio 3%)
Own azoles alcohol 40kg (weight ratio 40%)
NNO (dispersant) 15kg (weight ratio 15%)
Sodium alkyl benzene sulfonate (wetting agent) 5kg (weight ratio 5%)
Kaolin (filler) 37kg (weight ratio 37%)
The microbicide compositions that has synergistic effect by above-mentioned weight proportion weighing prepares raw material load weighted above-mentioned raw materials is fully mixed, and after airslide disintegrating mill is pulverized, mixes again, promptly obtains the own azoles alcohol of 50% polyoxin wetting powder finished product.
6000～8000 times of liquid of the preparation of proportioning are being better than single usefulness to the preventive effect of apple tree spot defoliation more than 90% according to the above ratio.
7 days preventive effects (%) behind the 60% polyoxin Difenoconazole WG control apple tree spot defoliation medicine
| Handle | I | II | III | IV | On average |
| 8000 times | 97.36 | 96.26 | 98.01 | 98.82 | 97.61 |
| 9000 times | 95.37 | 93.69 | 95.82 | 94.31 | 94.80 |
| 10000 times | 92.84 | 91.01 | 92.28 | 92.88 | 92.25 |
| 800 times of 10% polyoxin WG | 59.61 | 58.81 | 56.78 | 60.24 | 58.86 |
| 2000 times of 10% Difenoconazole WG | 73.05 | 72.63 | 72.59 | 73.64 | 72.97 |
7 days preventive effects (%) behind the own azoles alcohol of the 50% polyoxin WP control apple tree spot defoliation medicine
| Handle | I | II | III | IV | On average |
| 6000 times | 92.01 | 94.25 | 93.67 | 95.18 | 93.78 |
| 7000 times | 89.34 | 92.44 | 91.61 | 91.54 | 91.23 |
| 8000 times | 88.52 | 90.64 | 90.25 | 91.89 | 90.32 |
| 800 times of 10% polyoxin WP | 54.26 | 50.07 | 56.78 | 52.37 | 53.37 |
| 2000 times of 5% own azoles alcohol SC | 63.77 | 65.34 | 68.06 | 67.42 | 66.14 |
Embodiment 6
Prepare 60% polyoxin RH-7592 wetting powder 100kg
Polyoxin 20kg (weight ratio 20%)
RH-7592 40kg (weight ratio 40%)
NNO (dispersant) 15kg (weight ratio 15%)
Alkyl benzene calcium sulfonate (wetting agent) 7kg (weight ratio 7%)
White carbon (filler) 18kg (weight ratio 18%)
The microbicide compositions that has synergistic effect by above-mentioned weight proportion weighing prepares raw material load weighted above-mentioned raw materials is fully mixed, and after airslide disintegrating mill is pulverized, mixes again, promptly obtains 60% polyoxin RH-7592 wetting powder finished product.
4000～5000 times of liquid of the preparation of proportioning more than 90%, are better than single usefulness to the preventive effect of apple tree spot defoliation according to the above ratio.
60% polyoxin RH-7592 wetting powder control apple tree spot defoliation preventive effect
Claims (6)
1, a kind ofly contains the microbicide compositions that polyoxin has synergistic function, it is characterized in that active components A is a polyoxin in the described composition, active component B is selected from a kind of in Difenoconazole, RH-7592, the own azoles alcohol at least, and wherein the ratio of weight and number of active components A and active component B is 1: 50～50: 1.
2, according to claim 1ly contain the microbicide compositions that polyoxin has synergistic function, the ratio of weight and number that it is characterized in that active components A and active component B is 1: 40～40: 1.
3, according to claim 2ly contain the microbicide compositions that polyoxin has synergistic function, the ratio of weight and number that it is characterized in that active components A and active component B is 1: 30～30: 1.
4, according to claim 3ly contain the microbicide compositions that polyoxin has synergistic function, the ratio of weight and number cumulative amount that it is characterized in that active components A and active component B is between 1～60.
5, claim 1 is described contains the application that polyoxin has the microbicide compositions of synergistic function, it is characterized in that active components A is mixed with into water dispersible granules or wetting powder with the agriculture chemicals fungicide composition that active component B forms with auxiliary material.
6,, it is characterized in that described auxiliary material contains 8～20 dispersants, 4～10 wetting agents, 10～40 carriers according to the described application of claim 5.
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| CN200810017312A CN100593970C (en) | 2008-01-17 | 2008-01-17 | Bactericide agent composition containing polyoxin having synergistic interaction and uses thereof |
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| CN200810017312A CN100593970C (en) | 2008-01-17 | 2008-01-17 | Bactericide agent composition containing polyoxin having synergistic interaction and uses thereof |
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| CN100593970C true CN100593970C (en) | 2010-03-17 |
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Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101755775B (en) * | 2009-11-03 | 2013-01-09 | 深圳诺普信农化股份有限公司 | Bactericidal composite taking fluazinam as main ingredient |
| CN102090407B (en) * | 2011-01-06 | 2014-02-19 | 陕西美邦农药有限公司 | Bactericidal composition containing bitertanol and antibiotic type compound |
| CN102067851B (en) * | 2011-01-20 | 2014-03-05 | 陕西美邦农药有限公司 | Antibacterial composition containing polyoxin and methoxyacrylate compound |
| CN102138564A (en) * | 2011-02-17 | 2011-08-03 | 陕西美邦农药有限公司 | Antibacterial composition containing polyoxin |
| CN102138561B (en) * | 2011-02-17 | 2014-03-19 | 陕西美邦农药有限公司 | Polyoxin-containing pesticide composition |
| CN102067873A (en) * | 2011-02-19 | 2011-05-25 | 陕西美邦农药有限公司 | Bactericidal composition containing polyoxin and triazole compound |
| CN102067857A (en) * | 2011-02-23 | 2011-05-25 | 陕西美邦农药有限公司 | Fungicide combination containing polyoxin |
| CN103814891B (en) * | 2014-01-23 | 2015-08-26 | 乳山韩威生物科技有限公司 | Polyoxin water dispersible granules, its preparation method and application |
| CN105340926A (en) * | 2015-12-11 | 2016-02-24 | 吉林农业大学 | Bactericidal composition containing mandipropamid and polyoxins and application of bactericidal composition |
| CN106942213A (en) * | 2017-04-12 | 2017-07-14 | 江苏金凤凰农化有限公司 | A kind of composition and application process that alternaria leaf spot of apple is treated based on guaiacol |
| CN116458511A (en) * | 2023-04-28 | 2023-07-21 | 陕西省蒲城美尔果农化有限责任公司 | A composition containing polyoxin and difenoconazole |
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2008
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Assignee: Shaanxi Meibang pesticide Co.,Ltd. Assignor: Zhang Shaowu Contract record no.: 2010610000036 Denomination of invention: Bactericide agent composition containing polyoxin having synergistic interaction and uses thereof Granted publication date: 20100317 License type: Exclusive License Open date: 20080806 Record date: 20100706 |
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Effective date of registration: 20191210 Address after: 715500 Pucheng County High-tech Industrial Development Zone, Weinan City, Shaanxi Province Patentee after: SHAANXI MEIBANG PHARMACEUTICAL GROUP Co.,Ltd. Address before: 715500 No. 23 grain market street, Chengguan Town, Pucheng County, Shaanxi Patentee before: Zhang Shaowu |
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