CN100577218C - Manufacturing method of artificial bone chip molding implant made of polyethylene plastic - Google Patents
Manufacturing method of artificial bone chip molding implant made of polyethylene plastic Download PDFInfo
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- CN100577218C CN100577218C CN200710170995A CN200710170995A CN100577218C CN 100577218 C CN100577218 C CN 100577218C CN 200710170995 A CN200710170995 A CN 200710170995A CN 200710170995 A CN200710170995 A CN 200710170995A CN 100577218 C CN100577218 C CN 100577218C
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- 229920003023 plastic Polymers 0.000 title claims abstract description 41
- 239000004033 plastic Substances 0.000 title claims abstract description 41
- 210000000988 bone and bone Anatomy 0.000 title claims abstract description 29
- 239000007943 implant Substances 0.000 title claims abstract description 23
- -1 polyethylene Polymers 0.000 title claims abstract description 23
- 239000004698 Polyethylene Substances 0.000 title claims abstract description 21
- 229920000573 polyethylene Polymers 0.000 title claims abstract description 21
- 238000000465 moulding Methods 0.000 title claims abstract description 11
- 238000004519 manufacturing process Methods 0.000 title claims description 17
- 239000002994 raw material Substances 0.000 claims abstract description 29
- 238000000034 method Methods 0.000 claims abstract description 27
- 239000002245 particle Substances 0.000 claims abstract description 23
- 238000010438 heat treatment Methods 0.000 claims abstract description 21
- 230000003068 static effect Effects 0.000 claims abstract description 17
- 238000002360 preparation method Methods 0.000 claims abstract description 8
- 238000005245 sintering Methods 0.000 claims abstract description 5
- 230000001788 irregular Effects 0.000 claims abstract description 4
- 229920001903 high density polyethylene Polymers 0.000 claims description 22
- 239000004700 high-density polyethylene Substances 0.000 claims description 22
- 239000000463 material Substances 0.000 claims description 18
- 239000004699 Ultra-high molecular weight polyethylene Substances 0.000 claims description 6
- 238000006243 chemical reaction Methods 0.000 claims description 6
- 239000008187 granular material Substances 0.000 claims description 6
- 229920000092 linear low density polyethylene Polymers 0.000 claims description 6
- 239000004707 linear low-density polyethylene Substances 0.000 claims description 6
- 238000012545 processing Methods 0.000 claims description 6
- 229920000785 ultra high molecular weight polyethylene Polymers 0.000 claims description 6
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims description 4
- 239000004810 polytetrafluoroethylene Substances 0.000 claims description 4
- 238000012216 screening Methods 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 2
- 239000010935 stainless steel Substances 0.000 claims description 2
- 229910001220 stainless steel Inorganic materials 0.000 claims description 2
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- 230000008855 peristalsis Effects 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 abstract description 7
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- 239000010419 fine particle Substances 0.000 abstract 1
- 238000007493 shaping process Methods 0.000 description 7
- 229920010741 Ultra High Molecular Weight Polyethylene (UHMWPE) Polymers 0.000 description 6
- 238000005303 weighing Methods 0.000 description 6
- 229920010126 Linear Low Density Polyethylene (LLDPE) Polymers 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 229920002554 vinyl polymer Polymers 0.000 description 5
- 238000005520 cutting process Methods 0.000 description 4
- 239000011236 particulate material Substances 0.000 description 4
- 229920001617 Vinyon Polymers 0.000 description 3
- CADZRPOVAQTAME-UHFFFAOYSA-L calcium;hydroxy phosphate Chemical class [Ca+2].OOP([O-])([O-])=O CADZRPOVAQTAME-UHFFFAOYSA-L 0.000 description 3
- 229910010272 inorganic material Inorganic materials 0.000 description 3
- 239000011147 inorganic material Substances 0.000 description 3
- 239000000523 sample Substances 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 229910001069 Ti alloy Inorganic materials 0.000 description 2
- 239000000956 alloy Substances 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 229910010293 ceramic material Inorganic materials 0.000 description 2
- 239000013068 control sample Substances 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 239000007799 cork Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000002513 implantation Methods 0.000 description 2
- 238000010030 laminating Methods 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 230000010287 polarization Effects 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 238000007920 subcutaneous administration Methods 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
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- 210000004027 cell Anatomy 0.000 description 1
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- 238000002474 experimental method Methods 0.000 description 1
- 210000003054 facial bone Anatomy 0.000 description 1
- 210000002454 frontal bone Anatomy 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 210000003701 histiocyte Anatomy 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 229920004889 linear high-density polyethylene Polymers 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
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- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 229910052756 noble gas Inorganic materials 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 210000003625 skull Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000010257 thawing Methods 0.000 description 1
- 229920001169 thermoplastic Polymers 0.000 description 1
- 239000004416 thermosoftening plastic Substances 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 238000005491 wire drawing Methods 0.000 description 1
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- Materials For Medical Uses (AREA)
Abstract
本发明涉及一种聚乙烯塑料制人工骨片成型植入物的制作方法，(a)制备原料：将初始状态的细颗粒聚乙烯塑料进行筛选，得到的颗粒表面具有数个凸出的隆起，呈不规则椭圆颗粒状；(b)制作模具：模具由模框、上模板和下模板组成；(c)加料：将经筛选的原料称量后均匀地撤布在模腔内；(d)静电取向：打开静电发生器电源开关，调整电压，将电压输出端的电极棒在模具上方进行缓慢的水平移动扫描，呈竖立状的颗粒随着电极棒移动方向倾斜，塑料颗粒呈规则交叉网状排列；(e)待静电取向工艺结束后，合上模盖，将模具放入加热炉中进行烧结。按本发明方法制成的人工骨片具有一定形状的微孔结构，便于人体组织细胞附着与生长，具有良好的生物相容性和物理性能。The present invention relates to a kind of preparation method of polyethylene plastic artificial bone chip molding implant, (a) preparation raw material: the fine particle polyethylene plastic of initial state is screened, and the particle surface that obtains has several protruding bulges, Irregular elliptical granular shape; (b) Mold making: the mold is composed of a mold frame, an upper template and a lower template; (c) feeding: the screened raw materials are weighed and evenly withdrawn from the mold cavity; (d) Static orientation: Turn on the power switch of the electrostatic generator, adjust the voltage, and move the electrode bar at the voltage output end slowly horizontally to scan above the mold. The vertical particles are inclined with the moving direction of the electrode bar, and the plastic particles are arranged in a regular cross-network ; (e) After the electrostatic orientation process is finished, close the mold cover, and put the mold into a heating furnace for sintering. The artificial bone piece made by the method of the invention has a microporous structure of a certain shape, is convenient for the attachment and growth of human tissue cells, and has good biocompatibility and physical properties.
Description
Technical field
The present invention relates to the artificial osteocomma of bio-medical, particularly a kind of manufacture method that adopts the artificial osteocomma formation implant of polyethylene kind plastic production bio-medical.
Background technology
Medical treatment is at present gone up the bone rehablitation project and mainly is divided into artificial joint and bone grafting material two big classes.
In recent years, the Puli of the external advanced country such as the U.S. restrains this (POREX) company and adopts the polyethylene kind plastics, makes implants such as artificial bone and artificial eye pedestal as linear low density polyethylene (LLDPE), ultra-high molecular weight polyethylene (UHMWPE), high density polyethylene (HDPE) (HDPE) etc.These organic molecules of being made up of carbon, the simple atom of hydrogen when molecular weight reaches certain magnitude, can present good physics and chemical property by polymerization and crosslinked, have better biocompatibility and safety non-toxic simultaneously.It is said that domestic some R﹠D institution also did corresponding test, but in the application of slim osteocomma, exist some problem.
Artificial osteocomma has multi-cellular structure, thawing by plastic grain when molding is heated, between the accumulation plastic grain, be connected to form skeleton, because plastic grain is piled up under free state, the artificial osteocomma that forms in the plane the mechanical strength of each point exist very big difference and porosity inconsistent, (thickness only is under 1～2mm) the situation making thin slice, its reaction is particularly evident, operative doctor is when cutting profile, the phenomenon that the edge part branch generating unit of osteocomma divides plastic grain to come off will produce bigger medical hidden danger thus.
Bone grafting material tradition is used medical titanium alloy material and ceramic material, because its processing and forming difficulty, the elastic modelling quantity height implants and can't close with tissue generation chain, in conjunction with difficulty, causes becoming flexible and fails.Some new bone grafting materials have appearred at present, as the artificial bone of being made by inorganic material such as calcium hydroxy phosphates.This material has better biocompatibility, and can be made into microcellular structure.But this material is brittle state, and impact strength is poor, and it is then cracked easily to implant when laminating, it is fixing to carry out shape finishing and punching in surgical operation, therefore its operating difficulties can only occur with the shape of artificial bone piece, does not use and do not recommend to do laminar artificial bone.
Summary of the invention
Task of the present invention provides a kind of manufacture method of improved artificial sclerite shaping implant with polyvinyl plastics, it has solved and has traditionally existed processing and forming difficulty, elastic modelling quantity height as bone grafting material, combines difficulty with tissue with inorganic material such as medical titanium alloy material, ceramic material, calcium hydroxy phosphates, or is poor, the problem such as cracked easily that implants of laminating of fragility, impact strength.
Technical solution of the present invention is as follows:
A kind of manufacture method of artificial sclerite shaping implant with polyvinyl plastics, make by following processing step:
(a) preparation raw material: the fine-grained polyethylene plastics of original state are screened, the particle size that obtains is 800 μ m～250 μ m, through claim measurement with measuring cup and balance, particulate bulk density is 180g/L～280g/L, particle surface has the protuberance of several protrusions, is irregular ellipse grains shape;
(b) make mould: mould is made up of framed, cope match-plate pattern and lower bolster, upper and lower template and framed employing matched in clearance, and the gap is 0.1mm～0.2mm, and template is slided up and down in framed like a cork;
(c) reinforced: as die bottom plate to be placed in the die cavity, will after the raw material weighing of screening, to be spread in the die cavity equably, and evenly between charge period, mould is vibrated slightly, make between the feed particles of initial shape to be the free state arrangement with the scraper plate sheaing is smooth;
(d) static orientation: adopt high-voltage D.C. generator or electrostatic generator, its running voltage is 220V, output voltage is 20kV～80kV, and voltage output end is excellent portion, and voltage output end rod portion and electrostatic generator electric power connection line place are provided with an insulating segment for operator's holding operation;
Open the electrostatic generator on and off switch, adjust voltage, the electrode bar of voltage output end is moved horizontally scanning slowly above mould, the feed particulate material of observing this moment in the die cavity is subjected to the effect of electrode and makes material surface produce polarization, the arrangement that the raw material that former free state is stacked is produced between feed particles to reaction by the utmost point of generating positive and negative voltage is wriggled, and be the setting shape in the particle length direction, along with moving of electrode bar, the granule of erectting shape is also along with the electrode bar moving direction tilts, when taking away electrode bar, plastic grain still has electric charge, treats that electric charge reduces gradually after several minutes, and it is regularly arranged that plastic grain promptly is;
(e) treat that the static orientation process finishes after, the die cap that closes is put into heating furnace with mould and is carried out sintering.
By manufacture method of the present invention, the artificial osteocomma of making is a kind of bone grafting material of thin slice class of non-bearing type.This artificial osteocomma as base material, is made into the osteocomma of the band microcellular structure with definite shape with vinyon, is convenient to human tissue cell and adheres to and growth.In the subcutaneous rat Implantation Test in 26 weeks, in the time in 4 weeks, histiocyte can run through whole osteocomma, fully demonstrates excellent biological compatibility usually.
The present invention adopts the granule powder of vinyon such as linear low density polyethylene (LLDPE), ultra-high molecular weight polyethylene (UHMWPE) or high density polyethylene (HDPE) (HDPE), behind the high-pressure electrostatic molecularly oriented, the mold pressing thermoplastic shaping, therefore improved the tensile strength and the impact strength of goods, thereby obtained comprehensively to run through that porous, plastic grain are that regular cross network is arranged, elastic modelling quantity is near the artificial osteocomma of non-bearing natural bone.
Be mainly used in the repairing filling of facial bone among the plastic surgery, frontal bone, cheekbone and skull etc. by the artificial osteocomma of manufacture method making of the present invention.Artificial osteocomma adopts certain size and thickness, operative doctor is selected the cutting cutting according to patient's position, if the normal saline that needs band circular arc position osteocomma can be put into 95 ℃ soaked 5～10 minutes, treat to bend to after the osteocomma deliquescing required circular-arc, again osteocomma is put into the normal saline cooling and shaping of room temperature.Because osteocomma thickness requires usually between 1～6mm, therefore, except having excellent biological compatibility, also has excellent physical property, as tensile strength and impact strength etc. as the osteocomma of loose micropore flake structure.
The present invention is easy to make, will be with a wide range of applications in fields such as the transplanting of bio-medical bone, repairing bone.
The specific embodiment
The present invention is a kind of manufacture method of artificial sclerite shaping implant with polyvinyl plastics, adopts following process steps to make:
1, preparation raw material: the raw material of artificial osteocomma adopts vinyon, can select linear low density polyethylene (LLDPE) for use, perhaps ultra-high molecular weight polyethylene (UHMWPE), perhaps high density polyethylene (HDPE) (HDPE); Also can select the mixture of linear low density polyethylene (LLDPE), ultra-high molecular weight polyethylene (UHMWPE) and high density polyethylene (HDPE) (HDPE) for use.
These materials are fine grain in original state, and the fine-grained polyethylene plastics are screened, and the particle size that obtains is 800 μ m～250 μ m, are preferably 600 μ m～350 μ m.By adopting measuring cup and balance to claim to measure, particulate bulk density is 180g/L～280g/L.Adopt 8 times of magnifieres to observe, particle surface has the protuberance of several protrusions, is irregular ellipse grains shape, and the ridge rough surface that protrudes, and with the floccule of a small amount of wire drawing shape.
2, make mould: mould is made up of three parts, promptly framed, cope match-plate pattern and lower bolster.Consider the magnetic field orientating of high-pressure electrostatic, the framed material in the mould is made by polytetrafluoroethylene (PTFE), but this material is at life-time service below 250 ℃; Cope match-plate pattern in the mould and lower bolster are made by stainless steel materials 1Cr18Ni9Ti, and sheet metal thickness is selected 6～10mm for use, so that conduction of heat.Upper and lower template and framed employing matched in clearance, the gap is 0.1mm～0.2mm, and template is slided up and down in framed more like a cork.
3, reinforced: that die bottom plate is placed in the die cavity, to after the raw material weighing of screening, be spread in the die cavity equably, and with scraper plate that the raw material sheaing is smooth evenly, between charge period, mould can be vibrated slightly, make to be free state between the feed particles of initial shape and to arrange.
4, static orientation: adopt high-voltage D.C. generator or electrostatic generator, its running voltage is 220V, and output voltage is 20～80kV.The output voltage of high-voltage D.C. generator or electrostatic generator is preferably 50kV～60kV.Voltage output end is bar-shaped, and its length is slightly larger than die cavity.Voltage output end rod portion and electrostatic generator electric power connection line place are provided with an insulating segment, so that operator's holding operation.
Open the electrostatic generator on and off switch, voltage output end promptly produces high-pressure electrostatic, adjusts voltage to 50kV～60kV, and the electrode bar that is about to voltage output end moves horizontally scanning slowly above mould; The feed particulate material that can be observed this moment in the die cavity is subjected to the effect of electrode and makes material surface produce polarization, and the arrangement that the raw material that former free state is stacked is produced between feed particles to reaction by the utmost point of generating positive and negative voltage is wriggled, and is the setting shape in the particle length direction; Along with moving of electrode bar, the granule of erectting shape is also along with the electrode bar moving direction tilts; When taking away electrode bar, plastic grain still has certain electric charge, treats that (for example 5 minutes) electric charge reduces gradually after several minutes, can see significantly this moment, the plastic grain of erectting shape lodges in proper order and presents necessarily regularly arrangedly, has so just reached the purpose that static is orientated.
The distance of electrode bar 30mm～80mm above mould of static orientation moves horizontally scanning highly slowly, and this distance highly is preferably 40mm～70mm.The electrode bar translational speed of static orientation is controlled at 0.15m/min～0.3m/min, its moving direction alternately moves at the vertical and horizontal of mould respectively, stop 5～10 minutes between each orientation that alternately moves, replace mobile number of times for vertically with laterally each 2～3 times, to reach the good granule state that interweaves.
5, treat that the static orientation process finishes after, the die cap that closes is put into heating furnace with mould and is carried out sintering.In heating process, can replenish nitrogen (N in the heating furnace
2) wait noble gas, to reduce the degree of oxidation of product surface.
Manufacture method of the present invention adopts the processing step of static orientation, carries out the high-pressure electrostatic orientation when die cavity Nei Shibu plastic grain raw material, by the intergranular interaction of electromagnetic field, with the condition that obtains to align.The static orientation adopts the similar scan method of high voltage electrostatic rod, and from the adjacent both sides of mould difference cross scan several times, the arrangement of orientation back plastic grain presents the cross network structure with rule row.To put into the heating furnace sintering behind the mould matched moulds, strict control temperature and pressure make the mode gradually fusion of plastic grain with inherently stable, and by well-regulated connection moulded products between granule.Especially molding sheet thickness is the artificial bone sheet articles of the conduct of δ=1mm by the inventive method, through the static orientation, when comparing, on the result of the test of tensile strength and impact strength, improved more than 15% respectively with the control sample that is orientated without static.
The artificial osteocomma that the present invention adopts the high-pressure electrostatic method for alignment to make detects through inspection center of Shanghai Plastic Inst. and inspection center of Shanghai Inst. of Materials, and the detection destination data is as follows:
Above testing result shows, sample of the present invention through orientation process is compared with the control sample that not oriented is handled, on the Main physical index, the former is significantly improved than the latter, especially tensile strength and impact strength have all improved more than 15%, modulus of elasticity in comperssion is reduced significantly, it only is 2.5 ‰ of the present medical titanium metal (200GMP) that uses, for common ultra-high molecular weight polyethylene (about 40% of 1300MPa～1500MPa), more approaching with the elastic modelling quantity of human body bone.Impact strength is that the calcium hydroxy phosphate inorganic material is made artificial bone (0.2KJ/m
2～0.5KJ/m
2) more than 20 times.
Artificial osteocomma sample of the present invention as formation implant in the subcutaneous rat Implantation Test, detect through 4 weeks, 12 weeks, 26 time-of-weeks respectively, and sampling is observed respectively, each phase tissue reaction's degree of sample is identical with the negative control product, the marginal portion does not have particulate material yet and is scattered during cutting sampling, has obtained the design result of use of expection.
Manufacture method by artificial sclerite shaping implant with polyvinyl plastics of the present invention in the process of experimentizing, has adopted linear high-density polyethylene (LLDPE) respectively to selecting for use of raw material, and model is DNDC-7150; Ultra-high molecular weight polyethylene (UHMWPE), model are HD450; High density polyethylene (HDPE) (HDPE), model are DMDY-1158.Its material is screened respectively, and the particle size of employing is 400 μ m～500 μ m.When above-mentioned particulate material heats in heating furnace, behind melt surface,, impose suitable pressure again and can form needed osteocomma size shape by the intergranular bonding skeleton that forms.Osteocomma takes out after cooling off and observes, can see and be full of micropore in the osteocomma, these micropores can reduce the elastic modelling quantity of this material, with elastic modelling quantity near natural person's bone, micropore is convenient to the inside growth of tissue behind the artificial osteocomma implant into body of conduct, to reach the better tissues compatibility.
Certainly in concrete experiment processing,, should select different heating-up temperatures, heat time heating time, briquetting pressure and mould respectively for use according to the difference of raw-material difference and goods.The HV generator that is adopted for example model is JIA-02, and its output voltage is 0～70kV, regulates in 30kV～65kV scope usually.
Further describe four experimental examples below:
Experimental example 1
Base plate is installed in the rectangle of a 120 * 100mm is framed, the linear low density polyethylene (LLDPE) of about 10g is put in weighing then, the raw material model is DNDC-7150, by vibration, wipe technology off, the high pressure torch is adjusted to 50kV, highly be in vertical apart from raw material 50mm, each cross scan secondary of transverse direction, finish the static orientation process, cover cope match-plate pattern, put into heating furnace and carry out heat-agglomerating, the 0.12MPa that on cope match-plate pattern, exerts pressure during heating, heating-up temperature is between 140 ℃～180 ℃, and the time is 60～105 minutes, then mould is taken out from heating furnace, be placed on and naturally cool in the room temperature about 60 ℃, last depanning can obtain the thin slice of 1mm left and right thickness.
Experimental example 2
Base plate is installed in the rectangle of a 120 * 100mm is framed, the ultra-high molecular weight polyethylene (UHMWPE) of about 20g is put in weighing then, the raw material model is HD450, by vibration, wipe technology off, the high pressure torch is adjusted to 60kV, highly be in vertical apart from raw material 70mm, each cross scan secondary of transverse direction, finish the static orientation process, cover cope match-plate pattern, put into heating furnace and carry out heat-agglomerating, the 0.25MPa that on cope match-plate pattern, exerts pressure during heating, heating-up temperature is between 160 ℃～225 ℃, and the time is 90～120 minutes, then mould is taken out from heating furnace, be placed on and naturally cool in the room temperature about 80 ℃, last depanning can obtain the thin slice of 2mm left and right thickness.
Experimental example 3
Base plate is installed in the rectangle of a 120 * 100mm is framed, the high density polyethylene (HDPE) (HDPE) of 30g is put in weighing then, the raw material model is DMDY-1158, by vibration, wipe technology off, the high pressure torch is adjusted to 40kV, highly be in vertical apart from raw material 40mm, each cross scan secondary of transverse direction is finished the static orientation process, covers cope match-plate pattern, put into heating furnace and carry out heat-agglomerating, the 0.1MPa that on cope match-plate pattern, exerts pressure during heating, heating-up temperature is between 150 ℃～190 ℃, and the time is 70～110 minutes, then mould is taken out from heating furnace, be placed on and naturally cool in the room temperature about 50 ℃, last depanning can obtain the thin slice of 3mm left and right thickness.
Experimental example 4
Base plate in being φ 145mm circular framed, is installed an internal diameter, the raw material (this raw material by the UHMWPE of 50% LLDPE and 50% through fully mixing) of about 58g is put in weighing then, by vibration, wipe technology off, the high pressure torch is adjusted to 65kV, highly locate to scan apart from raw material 60mm, scan respectively from three directions of 120 ° of the framed center of circle of circle angles, finish the static orientation process, cover upper mould cover, put into heating furnace and carry out heat-agglomerating, the 0.25MPa that on cope match-plate pattern, exerts pressure during heating, heating-up temperature is between 170 ℃～220 ℃, and the time is 80～110 minutes, then mould is taken out from heating furnace, be placed on and naturally cool in the room temperature about 60 ℃, last depanning can obtain the thin slice about 4mm.
Certainly, those skilled in the art in the present technique field will be appreciated that, the foregoing description only is to be used for illustrating the present invention, and be not as limitation of the invention, as long as in connotation scope of the present invention, all will drop in the scope of claim of the present invention conversion, the modification of the foregoing description.
Claims (9)
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| CN200710170995A CN100577218C (en) | 2007-11-27 | 2007-11-27 | Manufacturing method of artificial bone chip molding implant made of polyethylene plastic |
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|---|---|---|---|
| CN200710170995A CN100577218C (en) | 2007-11-27 | 2007-11-27 | Manufacturing method of artificial bone chip molding implant made of polyethylene plastic |
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| CN100577218C true CN100577218C (en) | 2010-01-06 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101746007B (en) * | 2008-12-11 | 2012-05-23 | 上海超高工程塑料有限公司 | Rotary rotational molding forming and manufacturing method for artificial eye pedestal implant |
| WO2011156512A2 (en) | 2010-06-08 | 2011-12-15 | Smith & Nephew, Inc. | Implant components and methods |
| CN103857415B (en) * | 2011-09-01 | 2016-08-17 | A·D·多斯塔 | Dental implant, vascular implant and tissue implant made of porous three-dimensional structures of polytetrafluoroethylene |
| IN2014DN06544A (en) * | 2012-02-10 | 2015-06-12 | Synthes Gmbh | |
| CN103272277B (en) * | 2013-05-28 | 2015-04-08 | 北京博辉瑞进生物科技有限公司 | Mold for preparing accellular small intestine submucosa matrix material |
| CN103272273B (en) * | 2013-05-28 | 2015-04-08 | 北京博辉瑞进生物科技有限公司 | Mold for preparing accellular small intestine submucosa matrix material |
| CN106362204A (en) * | 2016-08-30 | 2017-02-01 | 何仁英 | High-strength artificial bone material and preparation method thereof |
| CN119017728B (en) * | 2024-10-29 | 2025-02-21 | 上海珀利医用材料有限公司 | A method for preparing a porous polyethylene implant |
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