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CN100498271C - Low temperature thermostat - Google Patents

Low temperature thermostat Download PDF

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Publication number
CN100498271C
CN100498271C CNB2004100368306A CN200410036830A CN100498271C CN 100498271 C CN100498271 C CN 100498271C CN B2004100368306 A CNB2004100368306 A CN B2004100368306A CN 200410036830 A CN200410036830 A CN 200410036830A CN 100498271 C CN100498271 C CN 100498271C
Authority
CN
China
Prior art keywords
thermostat chamber
cryogenic thermostat
cryostat
lighting
lighting module
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB2004100368306A
Other languages
Chinese (zh)
Other versions
CN1538160A (en
Inventor
C·多伦坎普
S·屈恩克尔
G·奥普尔
P·舍克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leica Biosystems Nussloch GmbH
Original Assignee
Leica Biosystems Nussloch GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leica Biosystems Nussloch GmbH filed Critical Leica Biosystems Nussloch GmbH
Publication of CN1538160A publication Critical patent/CN1538160A/en
Application granted granted Critical
Publication of CN100498271C publication Critical patent/CN100498271C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D27/00—Lighting arrangements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/04—Devices for withdrawing samples in the solid state, e.g. by cutting
    • G01N1/06—Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D3/00—Devices using other cold materials; Devices using cold-storage bodies
    • F25D3/10—Devices using other cold materials; Devices using cold-storage bodies using liquefied gases, e.g. liquid air
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/42—Low-temperature sample treatment, e.g. cryofixation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/04—Devices for withdrawing samples in the solid state, e.g. by cutting
    • G01N1/06—Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome
    • G01N2001/068—Illumination means

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  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Combustion & Propulsion (AREA)
  • Mechanical Engineering (AREA)
  • Thermal Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Microscoopes, Condenser (AREA)
  • Arrangement Of Elements, Cooling, Sealing, Or The Like Of Lighting Devices (AREA)

Abstract

A cryostat (1), having a cryostat chamber (2) in which a microtome for cutting frozen specimens is arranged, is described. An illumination device (4) for illuminating the cryostat chamber (2) is provided, the illumination device (4) comprising at least one LED.

Description

Cryostat
Technical field
The present invention relates to a kind of cryostat with a cryogenic thermostat chamber and a lighting mechanism, the thin slice slicing mechanism (Mikrotom) that a microscope that is used to cut frozen preparation (gefrorenePraeparaten) is used is set in this cryogenic thermostat chamber, and described lighting mechanism is used for throwing light on for the cryogenic thermostat chamber.
Background technology
This cryostat is used for cutting by a microtome structure and is used for the frozen preparation that and then utilizes a microscope to observe.The preparation that is cut is frozen to some given temperature.Be usually located between-10 ℃ to-50 ℃ in this temperature.In order to guarantee constant temperature, the thin slice slicing mechanism that microscope is used is arranged in the cryogenic thermostat chamber of a bothersome sealing cover, and correspondingly cools off the thin slice slicing mechanism that this microscope is used.
In order to guarantee to work reliably, lamp lighting is passed through in the cryogenic thermostat chamber.But there is defective in this, and described light source produces heat and impairs the constant temperature that has decisive role for the cutting of preparation.
Verified in addition, the light source of large-size is difficult to cleaning.
Summary of the invention
Therefore task of the present invention is, improves the lighting mechanism of cryogenic thermostat chamber like this, makes to obtain a better constant temperature in the cryogenic thermostat chamber.
Task of the present invention is finished by a kind of cryostat, it has cryogenic thermostat chamber and lighting mechanism, in the cryogenic thermostat chamber, be provided with the microtome structure that is used to cut frozen preparation, and lighting mechanism is used for throwing light on for the cryogenic thermostat chamber, according to the present invention, described lighting mechanism has a plurality of light-emitting diode group that are assembled into lighting module, and is provided with wiring, and this wiring is used to make lighting module to connect and deepening.Described lighting mechanism as light source has at least one light emitting diode, especially white light emitting diode.Realize the heat radiation of a compact structure form, a kind of very pettiness and good spatter property and sterilization property by this light emitting diode.This UV light-emitting diode can very well be guarded against sputter water by its spatial form.
A plurality of light emitting diodes are assembled into a lighting module in a kind of scheme of the present invention.Realize higher illuminance with a compact structure form thus.The electric contact of light-emitting diode group also can very well be guarded against moisture and sputter water in addition.
Have a housing at lighting module described in the improvement project of the present invention, this housing has a plug-in connection that is used to power.Described lighting module can be arranged in the cryogenic thermostat chamber replaceably by this plug-in connection.Single or multiple lighting modules can be arranged on replaceably as required in the ready plug holding mechanism in the cryogenic thermostat chamber.
A plurality of lighting modules are electrically connected with a common power supply in another kind of scheme of the present invention.Therefore this power supply is preferably disposed on the outside of cryogenic thermostat chamber, also can reduce heat release except expending minimum.
In another kind of scheme of the present invention, be provided with a wiring, be used to switch on and off single and/or a plurality of lighting modules.Therefore can throw light on to single zone in the cryogenic thermostat chamber interior according to request for utilization.
This wiring additionally has the function of an attenuator for single and/or a plurality of lighting modules in a favourable improvement project.The cryogenic thermostat chamber of can optionally throwing light on thus.
In another improvement project of the present invention, a switch is set on cryostat and is electrically connected with wiring, wherein switch makes single and/or a plurality of lighting modules connect automatically and/or deepening when opening and/or cutting out the cryogenic thermostat chamber.Utilize this function, when opening cover plate or glass sheet, can automatically control the illuminating ray of cryogenic thermostat chamber interior by the user.For example can when opening, always be switched to thus in the best illumination, and when closing, disconnect single lighting module or make its deepening.Therefore have only the cutter of the thin slice slicing mechanism that sample mount and/or microscope use illuminated under the situation of the cryogenic thermostat chamber of closing, this is very significant.
In another kind of scheme of the present invention, at least one light emitting diode is disposed a sputter water fender.Advantageously, lighting module can be furnished with sealer, and the sealing thing is used to cover the light emitting diode electric contact.
Description of drawings
Describe the present invention in detail by an embodiment shown in the drawings.Accompanying drawing illustrates:
The view of Fig. 1 cryostat,
The sectional view of Fig. 2 lighting module,
The vertical view of Fig. 3 lighting module,
Fig. 4 has the vertical view of the cryostat of cryogenic thermostat chamber.
Embodiment
Fig. 1 illustrates the diagrammatic sketch of the cryostat 1 with a cryogenic thermostat chamber 2, and a lighting mechanism 4 with a plurality of lighting modules 6 is set in this cryogenic thermostat chamber.Cryogenic thermostat chamber 2 can by one movably cover plate 17 open or close.Lighting module 6 is connected electrically on the wiring 10 by lead 14, and is connected electrically on the power supply 9 by lead 15.A switch 11 is set, the opening and closing of the cover plate 17 of its record cryogenic thermostat chamber 2 on cryostat 1.This switch 11 is connected with described wiring by a unshowned lead equally.
Can make single or all lighting modules 6 are connected and/or deepenings by wiring 10.By switch 11 single and/or a plurality of lighting modules 6 are connected and/or deepening automatically.
Fig. 2 illustrates the sectional view of a lighting module 6, and this lighting module has a housing 7 and single light-emitting diode group 5, and they are arranged on the circuit board 13.The electric contact of this circuit board 13 or light-emitting diode group 5 is avoided ectocine ground by a sputter water fender 12 that is arranged on the housing and is realized sealing.
Fig. 3 illustrates lighting module 6 with vertical view, and this lighting module has a side and is arranged on plug-in connection 8 on the housing 7.Can make lighting module 6 be fixed in the cryogenic thermostat chamber 2 and power supply simultaneously by this plug-in connection 8.
Fig. 4 illustrates the vertical view of cryogenic thermostat chamber 2, and this cryogenic thermostat chamber has thin slice slicing mechanism 3 that microscope that the center is provided with uses and the lighting module 6 that is provided with around this mechanism 3.By this layout, in the cryostat 1 inner even illumination that realizes all sites.Also be furnished with one freezing 16 the thin slice slicing mechanism of using except microscope in cryogenic thermostat chamber 23, this freezing is used for the snap frozen preparation and is used to place a plurality of preparation supports.In order to throw light on for freezing 16, the lighting module 6 of self is set.
Reference numerals list
1, cryostat
2, cryogenic thermostat chamber
3, the thin sheet cutter structure used of microscope
4, lighting mechanism
5, light emitting diode
6, lighting module
7, housing
8, plug-in connection
9, power supply
10, wiring
11, switch
12, sputter water fender
13, circuit board
14, lead
15, electric wire
16, freezing
17, cover plate

Claims (3)

1. the cryostat (1) that has a cryogenic thermostat chamber (2) and a lighting mechanism (4), a microtome structure (3) that is used to cut frozen preparation is set in this cryogenic thermostat chamber, this lighting mechanism (4) is used for throwing light on for cryogenic thermostat chamber (2), it is characterized in that, described lighting mechanism (4) has a plurality of light-emitting diode group (5) that are assembled into a lighting module (6), and be provided with wiring (10), this wiring (10) is used to make lighting module (6) to connect and deepening.
2. cryostat as claimed in claim 1 (1) is characterized in that, described lighting module (6) has a housing (7), and this housing has a plug-in connection that is used to power (8).
3. cryostat as claimed in claim 1 (1), it is characterized in that, a switch (11) and this switch are set on described cryostat (1) are electrically connected with wiring (10), described switch (11) makes lighting module (6) connect automatically or deepening when opening or closing cryogenic thermostat chamber (2).
CNB2004100368306A 2003-04-19 2004-04-19 Low temperature thermostat Expired - Fee Related CN100498271C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10318026.5 2003-04-19
DE10318026.5A DE10318026C5 (en) 2003-04-19 2003-04-19 Cryostat with lighting device

Publications (2)

Publication Number Publication Date
CN1538160A CN1538160A (en) 2004-10-20
CN100498271C true CN100498271C (en) 2009-06-10

Family

ID=32010540

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB2004100368306A Expired - Fee Related CN100498271C (en) 2003-04-19 2004-04-19 Low temperature thermostat

Country Status (5)

Country Link
US (1) US20040206093A1 (en)
JP (1) JP2004317515A (en)
CN (1) CN100498271C (en)
DE (2) DE20321622U1 (en)
GB (1) GB2400645B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4840763B2 (en) * 2006-01-18 2011-12-21 セイコーインスツル株式会社 Automatic thin section preparation apparatus and automatic thin section preparation apparatus
DE102009061068B4 (en) 2009-04-17 2015-05-07 Leica Biosystems Nussloch Gmbh Method for producing microscopic thin sections of tissue samples
WO2011123607A2 (en) * 2010-03-31 2011-10-06 Hilin Life Products Inc. Novel ovulation predictor device
DE102011002443B4 (en) * 2011-01-04 2013-08-29 Leica Biosystems Nussloch Gmbh Cryostat with lighting device
DE102012215859A1 (en) 2012-09-06 2014-03-06 Leica Biosystems Nussloch Gmbh Processing device for processing tissue samples with a reader device for user identification units

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Also Published As

Publication number Publication date
DE10318026B4 (en) 2010-05-27
GB2400645A (en) 2004-10-20
US20040206093A1 (en) 2004-10-21
CN1538160A (en) 2004-10-20
DE10318026A1 (en) 2004-11-04
DE10318026C5 (en) 2015-11-12
DE20321622U1 (en) 2008-07-17
JP2004317515A (en) 2004-11-11
GB0403255D0 (en) 2004-03-17
GB2400645B (en) 2005-06-29

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PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20090610

Termination date: 20170419