CN100496251C - Fipronil and rh-5849 compound insecticide - Google Patents

Abstract

The invention relates to compound pesticide of fipronil and RH-5849, which comprises effective active ingredients, auxiliary agents and water. The invention is characterized in that the percentage by weight of the effective active ingredients which made form the fipronil and the RH-5849 is 5.5 to 50 percent against the finished product agent, the percentages by weight of the fipeonil and the RH-5849 against the effective active ingredients are respectively 5 to 90 percent and 10 to 95 percent.

Description

Fipronil antifeeding hydrazine compound insecticide

Technical field:

The invention belongs to a pesticide for preventing and controlling agricultural pests and a preparation method thereof, and relates to a composite insecticide whose effective active ingredients are fipronil and hydrazine.

Background technique:

Rice leaf roller is an important migratory pest of rice production in the country. Since the beginning of the 21st century, only moderate to heavy occurrences occurred in 2001 and 2006, and outbreaks occurred year after year, posing a serious threat to rice production. The rice leaf roller occurs in a large number of years, and the generations often overlap, and the instars are irregular. However, the pesticides currently used in production have a short duration of effectiveness, usually 3-5 days for controlling damage, which cannot meet the requirements for controlling the damage of leaf rollers, and there is a serious shortage of pesticides with good control effects on older larvae. Therefore, research and development of pesticide products with high control efficiency and long-lasting effect on rice leaf rollers has become a top priority. For a long time, most of the pesticides used in my country's agricultural production are powder preparations and emulsifiable concentrate preparations. The filler dust and a large amount of organic solvents in these preparations are likely to pollute the environment. direction of development.

Fipronil, English common name fipronil; chemical name (±)-5-amino-1-(2,6-dichloro-α,α,α-trifluoro-β-tolyl)-4-trifluoromethyl Sulphinylpyrazole-3-carbonitrile, other names: sharp neck special. It mainly has contact killing and stomach poisoning effects on insects, strong systemic effect on rice, and moderate knockdown activity. Its mechanism of action is to disrupt central conduction in the insect central nervous system by blocking gamma-aminobutyric acid (GABA)-regulated chloride transmission. Fipronil has high activity against aphids, planthoppers, leafhoppers, lepidopteran larvae, flies and coleopteran pests, and has been produced against cyclopentadiene, pyrethroid or carbamate insecticides Resistant insects are susceptible.

Suppression hydrazine, the chemical name is 2'-benzoyl-1'-tert-butylbenzoylhydrazine; 2'-benzoyl-1'-tert-butyl-benzoylhydrazine, other names: Chongsijing, RH5849. It is mainly stomach-toxic to pests, has strong systemic properties, and has a long-lasting effect. The main mechanism of action is to inhibit feeding, hinder the normal molt of insects, accelerate molt and reduce oviposition. It has high activity against pests of Lepidoptera, Coleoptera and Diptera, and has excellent control effect against resistant potato beetles.

The use of fipronil and hydrazine alone to control rice leaf rollers requires a large dosage and high cost, and the repeated use of pests is likely to produce resistance.

Invention content:

The purpose of the present invention is to: aim at the limitations of the current chemical pesticides in the control of rice leaf rollers and the use of fipronil and hydrazine alone in the control of rice leaf rollers is relatively large, the cost is high, and the repeated use of pests is easy to produce resistance. In order to solve the practical problem of sex, a kind of fipronil antifeeding hydrazine compound insecticide and its preparation method are provided.

The purpose of the present invention is achieved in this way: a fipronil antifeeding hydrazine compound insecticide, comprising effective active ingredients, auxiliary agents and water, is characterized in that: the effective active ingredients account for 5.5 to 50% by weight of the finished medicament %, the effective active ingredients are composed of fipronil and hydrazine, and their weight percentages in the active ingredients are: 5-90% of fipronil and 10-95% of hydrazine.

In the compound insecticide involved in the present invention, the weight percentage of the auxiliary agent in the compound insecticide is 5-20%, and the rest is water.

In the compound insecticide involved in the present invention, the auxiliary agents include: wetting and dispersing agents, emulsifiers, antifreeze agents, thickeners, and defoamers.

In the compound pesticide involved in the present invention, the dosage form of the compound pesticide is a suspension.

The advantage of the present invention is that: since the mechanism of action of fipronil and hydrazine on the target pests is completely different, the combination of the two can fully improve the efficacy of the drugs, improve the insecticidal effect, reduce the dosage, reduce the cost, and delay the pest control. The generation of resistance; it has obvious synergistic effect, long-lasting effect and high control effect; it has expanded the insecticidal spectrum and has high activity against Lepidoptera pests such as rice leaf roller, rice stem borer, and rice stem borer; The usage amount of active ingredients is reduced, and the residual amount of pesticides on crops is reduced; the invention is a water-based pesticide preparation, which contains few organic solvents, which reduces environmental pollution; the product has low toxicity, is safe for humans and animals, and is environmentally compatible Good, pests are not easy to develop resistance.

Detailed ways:

Example 1

Preparation of fipronil antifeeding hydrazine compound insecticide:

The original drug of fipronil was provided by Anhui Huaxing Chemical Co., Ltd. (the same below);

The original drug of hydrazine was produced by Jiangsu Gengyun Chemical Co., Ltd. (the same below).

Additives include: AEA-2 (wetting and dispersing agent), OP-10 (emulsifier), Lf116 (emulsifier), ethylene glycol (antifreeze), xanthan gum (thickener), organic silicone (disinfectant) Foaming agent), wherein Lf116 is provided by Nanjing Zhongshan Chemical Plant No. 2, and the rest are purchased through the market.

Formula (according to weight percentage): fipronil: 1.2%; hydrazine: 9.6%; AEA-2: 2%; OP-10: 5%; Lf116: 6%; xanthan gum: 0.1%; organosilicone : 0.01%; Ethylene Glycol: 2%; Water: Appropriate amount.

Preparation Process

Weigh the original drug and additives of fipronil and hydrazine in proportion, put them in the reaction kettle, add water to 100% and mix evenly;

Then introduce the mixture into a sand mill and grind until the fineness of the material is 0.1-1um, and mix uniformly to form a water suspending agent. In the water suspension, the effective active ingredients account for 10.8% by weight of the finished medicament.

Example 2

Indoor Activity Assay (1)

Insects to be tested:

The rice leaf roller is an adult caught in the rice field of Jiangsu Academy of Agricultural Sciences. It was reared indoors until it laid eggs, and the ant borer hatched for 4 days was used for determination.

Medication tested:

Using the auxiliary agent of Example 1, it is formulated into two groups of combinations whose effective activity accounts for 10% and 10.8% of the finished medicament (weight) respectively. The ratios are 1:4 and 1:5 respectively.

Contrast drugs:

5% fipronil suspension concentrate (produced by Bayer Crop Science Co., Ltd., the same below);

20% hydrazine wettable powder (produced by Jiangsu Shenghua Pesticide Co., Ltd., the same below).

test methods:

Measured by dipping method. Dilute the compound combination of fipronil and hydrazine 1:4, the compound combination of hydrazine and hydrazine 1:5, the single dose of fipronil, and the single dose of hydrazine with water to form a series of concentrations of the test drug solution, and treated with water as the blank control. Immerse the rice seedlings in each test drug solution and the blank control for 15 seconds, take them out and dry them, put them into test tubes, inoculate 20 insects in each tube, place them in a constant temperature room at 28±2°C, and investigate the number of dead insects 48 hours after the treatment. The co-toxicity coefficient was calculated according to the method proposed by Sun Yunpei et al. (1960).

The results of indoor synergistic tests (Table 2) show that the co-toxicity coefficients of fipronil and hydrazine against rice leaf rollers are 186.57 and 178.71 respectively according to the active ingredients of 1:4 and 1:5. Both compound combinations had significant synergistic effect on rice leaf roller.

Table 1 The indoor activity test results of fipronil and hydrazine and their compound combination against rice leaf roller

potion regression equation LC50(mg/L) co-toxicity coefficient 5% Fipronil Suspended Concentrate Y=4.6591+2.4086x 1.3853 / 20% Hydrazine wettable powder Y=-2.1304+2.6390x 503.4259 / 10% Fipronil · Hydrazine Suspending Concentrate 1:4 Y=4.0319+1.7137x 3.6722 186.57 10.8% Fipronil · Hydrazine Suspension Concentrate 1:5 Y=3.8782+1.6958x 4.5870 178.71

Embodiment 3,

Indoor Activity Assay (2)

Insects to be tested: Chilo borer eggs were collected from Gaochun County, Nanjing City, Jiangsu Province. They were reared indoors for 2 generations, and the ant borer hatched for 4 days was used for determination.

The difference between the test medicament and Example 2 is only that the test medicament is two groups of combinations whose effective activity accounts for 10.8% and 14% of the finished drug (weight), and in the two groups of combinations, the effective active ingredient fluoride The weight proportions of nitrile and hydrazine are 1:5 and 1:6 respectively.

The contrast agent is the same as in Example 2.

test methods

Measured by dipping method. Dilute the compound combination of fipronil and hydrazine 1:4, the compound combination of hydrazine and hydrazine 1:5, the single dose of fipronil, and the single dose of hydrazine with water to form a series of concentrations of the test drug solution, and treated with water as the blank control. Immerse the rice seedlings in each test drug solution and the blank control for 15 seconds, take them out and dry them, put them into test tubes, inoculate 20 insects in each tube, place them in a constant temperature room at 28±2°C, and investigate the number of dead insects 48 hours after the treatment. The co-toxicity coefficient was calculated according to the method proposed by Sun Yunpei et al. (1960).

The results of indoor synergistic tests (Table 2) show that the co-toxicity coefficients of fipronil and hydrazine were 166.09 and 155.89 respectively for the two compounded agents according to the active ingredients of 1:5 and 1:6. The combination showed obvious synergistic effect on rice stem borer.

Table 2 Indoor activity test results of fipronil, hydrazine and their compound against rice stem borer

potion regression equation LC₅₀(mg/L) co-toxicity coefficient 5% Fipronil Suspended Concentrate Y=8.0137+2.9496x 0.0951 / 20% Hydrazine wettable powder Y=1.9684+1.7920x 49.1722 / 10.8% Fipronil · Hydrazine Suspension Concentrate 1:5 Y=5.9372+2.0016x 0.3402 166.09 14% Fipronil · Hydrazine Suspending Concentrate 1:6 Y=5.7611+2.0312x 0.4220 155.89

Embodiment 4,

field efficacy test

Test time: On August 1, 2007, it was carried out in the paddy field of Jiangjia Village, Chunxi Town, Gaochun County.

Test drug

5% fipronil suspension concentrate;

20% Hydrazine wettable powder.

Fipronil and hydrazine compound insecticide (provided in Example 1, the active ingredient accounts for 10.8% by weight of the finished medicament, and the ratio of the active ingredients of fipronil and hydrazine is 1:8).

The test was applied at the peak period of the 1st instar larvae of the rice leaf roller and the peak period of the egg hatching of the rice stem borer. The single agent and the compound agent were mixed with 60Kg of water per mu to make a liquid, and sprayed evenly to spray Qingshui was treated as blank control, with 4 plots for each treatment, each plot area 33.3m ² , each treatment plot was separated by small ridges, and protection rows were set up, and the plots were arranged in random blocks. 11 days and 15 days after spraying, the parallel jumping method was used to sample at 5 points, the number of rolled leaves was investigated, and the number of residual live insects was stripped to calculate the control effect. See Table 3 for the results of the field test.

The test results show that: 10.8% fipronil · hydrazine suspension concentrate, 15 days after spraying, the insecticidal effect of controlling rice stem borer is 91.63%. 11 days after spraying, the leaf-preserving effect of controlling rice leaf roller was 93.08%, and the insecticidal effect was 90.34%. The control effect of 10.8% fipronil · hydrazine suspending agent on rice stem borer and rice leaf roller is better than that of 5% fipronil suspending agent and 20% hydrazine WP.

Table 3 Field control effects of fipronil, hydrazine and their compound agents on rice stem borer and leaf roller

The above-mentioned embodiments are not specific limitations to the present invention. During specific implementation, the weight percentage of the effective active ingredients in the finished drug is 5.5-50%, and the effective active ingredients are composed of fipronil and hydrazine. The weight percent of the ingredients is: 5-90% of fipronil and 10-95% of hydrazine. The weight percent of the auxiliary agent in the compound insecticide is 5-20% and an appropriate amount of water.

Claims (3)

1. A fipronil antifeeding hydrazine compound insecticide, including effective active ingredients, auxiliary agents and water, characterized in that: the effective active ingredients account for 5.5-50% by weight of the finished drug, and the effective activity The ingredients are composed of fipronil and hydrazine, and their weight percentages in the active ingredients are: 5-90% of fipronil and 10-95% of hydrazine. 2. The compound insecticide of fipronil and antifeeding hydrazine according to claim 1, characterized in that the content of the additive in the compound insecticide is 5-20% by weight, and the rest is water. 3. The compound insecticide of fipronil and hydrazine according to claim 1 or 2, characterized in that the dosage form of the compound insecticide is a suspension.