CN100488381C - Propolis ganoderma lucidum spore, dried black fungus polysaccharide compounded soft capsule and preparing process therefor - Google Patents
Propolis ganoderma lucidum spore, dried black fungus polysaccharide compounded soft capsule and preparing process therefor Download PDFInfo
- Publication number
- CN100488381C CN100488381C CNB2006100097464A CN200610009746A CN100488381C CN 100488381 C CN100488381 C CN 100488381C CN B2006100097464 A CNB2006100097464 A CN B2006100097464A CN 200610009746 A CN200610009746 A CN 200610009746A CN 100488381 C CN100488381 C CN 100488381C
- Authority
- CN
- China
- Prior art keywords
- polysaccharide
- propolis
- filter
- lucidum spore
- powder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 241000241413 Propolis Species 0.000 title claims abstract description 36
- 229940069949 propolis Drugs 0.000 title claims abstract description 36
- 150000004676 glycans Chemical class 0.000 title claims abstract description 35
- 239000005017 polysaccharide Substances 0.000 title claims abstract description 35
- 229920001282 polysaccharide Polymers 0.000 title claims abstract description 35
- 239000007901 soft capsule Substances 0.000 title claims abstract description 13
- 241000233866 Fungi Species 0.000 title claims description 19
- 238000000034 method Methods 0.000 title claims description 15
- 240000008397 Ganoderma lucidum Species 0.000 title claims description 6
- 235000001637 Ganoderma lucidum Nutrition 0.000 title claims description 6
- 230000008569 process Effects 0.000 title description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 42
- 229930003427 Vitamin E Natural products 0.000 claims abstract description 21
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract description 21
- 239000011709 vitamin E Substances 0.000 claims abstract description 21
- 235000019165 vitamin E Nutrition 0.000 claims abstract description 21
- 229940046009 vitamin E Drugs 0.000 claims abstract description 21
- 239000000843 powder Substances 0.000 claims abstract description 20
- 235000000023 Auricularia auricula Nutrition 0.000 claims abstract description 17
- 239000000284 extract Substances 0.000 claims abstract description 12
- 239000000203 mixture Substances 0.000 claims abstract description 11
- 235000015112 vegetable and seed oil Nutrition 0.000 claims abstract description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 43
- 239000002994 raw material Substances 0.000 claims description 17
- 238000001556 precipitation Methods 0.000 claims description 16
- 239000007788 liquid Substances 0.000 claims description 13
- 239000000463 material Substances 0.000 claims description 13
- 238000003756 stirring Methods 0.000 claims description 12
- 238000001035 drying Methods 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 241000514697 Lepidothamnus laxifolius Species 0.000 claims description 9
- 235000010450 Pino mugo Nutrition 0.000 claims description 9
- 239000000706 filtrate Substances 0.000 claims description 9
- 238000001914 filtration Methods 0.000 claims description 9
- 239000003292 glue Substances 0.000 claims description 9
- 241000221377 Auricularia Species 0.000 claims description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- 239000012141 concentrate Substances 0.000 claims description 6
- 239000004744 fabric Substances 0.000 claims description 6
- 239000008188 pellet Substances 0.000 claims description 6
- 239000002893 slag Substances 0.000 claims description 6
- 230000001954 sterilising effect Effects 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 5
- 238000004659 sterilization and disinfection Methods 0.000 claims description 5
- 241001236210 Pinus pumila Species 0.000 claims description 4
- 238000000227 grinding Methods 0.000 claims description 4
- 239000010665 pine oil Substances 0.000 claims description 4
- 210000002966 serum Anatomy 0.000 claims description 4
- 108010010803 Gelatin Proteins 0.000 claims description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 3
- 238000013019 agitation Methods 0.000 claims description 3
- 238000010009 beating Methods 0.000 claims description 3
- 230000008859 change Effects 0.000 claims description 3
- 238000001816 cooling Methods 0.000 claims description 3
- 229920000159 gelatin Polymers 0.000 claims description 3
- 239000008273 gelatin Substances 0.000 claims description 3
- 235000019322 gelatine Nutrition 0.000 claims description 3
- 235000011852 gelatine desserts Nutrition 0.000 claims description 3
- 235000011187 glycerol Nutrition 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- 238000009413 insulation Methods 0.000 claims description 3
- 238000002386 leaching Methods 0.000 claims description 3
- 238000010025 steaming Methods 0.000 claims description 3
- 238000001291 vacuum drying Methods 0.000 claims description 3
- 241001149430 Auricularia auricula-judae Species 0.000 claims 3
- 244000028550 Auricularia auricula Species 0.000 abstract description 14
- 241000222336 Ganoderma Species 0.000 abstract description 13
- 238000002360 preparation method Methods 0.000 abstract description 6
- 235000008331 Pinus X rigitaeda Nutrition 0.000 abstract description 2
- 241000018646 Pinus brutia Species 0.000 abstract description 2
- 235000011613 Pinus brutia Nutrition 0.000 abstract description 2
- 239000002131 composite material Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 14
- 210000004369 blood Anatomy 0.000 description 9
- 239000008280 blood Substances 0.000 description 9
- 238000005516 engineering process Methods 0.000 description 9
- 239000002253 acid Substances 0.000 description 8
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 8
- 230000036541 health Effects 0.000 description 8
- 239000000047 product Substances 0.000 description 8
- 210000004204 blood vessel Anatomy 0.000 description 6
- -1 phosphatide Natural products 0.000 description 6
- 238000010521 absorption reaction Methods 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 5
- 210000001519 tissue Anatomy 0.000 description 5
- 206010028980 Neoplasm Diseases 0.000 description 4
- 230000006378 damage Effects 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 235000013399 edible fruits Nutrition 0.000 description 4
- 235000019197 fats Nutrition 0.000 description 4
- 235000013402 health food Nutrition 0.000 description 4
- 230000003647 oxidation Effects 0.000 description 4
- 238000007254 oxidation reaction Methods 0.000 description 4
- 206010020772 Hypertension Diseases 0.000 description 3
- 239000003963 antioxidant agent Substances 0.000 description 3
- 235000006708 antioxidants Nutrition 0.000 description 3
- 201000011510 cancer Diseases 0.000 description 3
- 239000000470 constituent Substances 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 150000002632 lipids Chemical class 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 235000019198 oils Nutrition 0.000 description 3
- 230000002265 prevention Effects 0.000 description 3
- 150000003254 radicals Chemical class 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 208000001953 Hypotension Diseases 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 240000000249 Morus alba Species 0.000 description 2
- 235000008708 Morus alba Nutrition 0.000 description 2
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 2
- 208000034189 Sclerosis Diseases 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 230000003712 anti-aging effect Effects 0.000 description 2
- 230000003064 anti-oxidating effect Effects 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 230000003078 antioxidant effect Effects 0.000 description 2
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 description 2
- 210000001367 artery Anatomy 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000036772 blood pressure Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000000084 colloidal system Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000009931 harmful effect Effects 0.000 description 2
- 230000001077 hypotensive effect Effects 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 230000015788 innate immune response Effects 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 230000004089 microcirculation Effects 0.000 description 2
- 210000004165 myocardium Anatomy 0.000 description 2
- 239000002417 nutraceutical Substances 0.000 description 2
- 235000021436 nutraceutical agent Nutrition 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 230000000050 nutritive effect Effects 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 239000012744 reinforcing agent Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 150000003722 vitamin derivatives Chemical class 0.000 description 2
- 239000002023 wood Substances 0.000 description 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 241000221454 Auriculariaceae Species 0.000 description 1
- 235000017166 Bambusa arundinacea Nutrition 0.000 description 1
- 235000017491 Bambusa tulda Nutrition 0.000 description 1
- 241000221198 Basidiomycota Species 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 206010008190 Cerebrovascular accident Diseases 0.000 description 1
- 206010010144 Completed suicide Diseases 0.000 description 1
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 108010082495 Dietary Plant Proteins Proteins 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 102000014150 Interferons Human genes 0.000 description 1
- 108010050904 Interferons Proteins 0.000 description 1
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 description 1
- 102000008109 Mixed Function Oxygenases Human genes 0.000 description 1
- 108010074633 Mixed Function Oxygenases Proteins 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 1
- 102000004316 Oxidoreductases Human genes 0.000 description 1
- 108090000854 Oxidoreductases Proteins 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 244000082204 Phyllostachys viridis Species 0.000 description 1
- 235000015334 Phyllostachys viridis Nutrition 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
- 241000124033 Salix Species 0.000 description 1
- 229930182558 Sterol Natural products 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 1
- JZRWCGZRTZMZEH-UHFFFAOYSA-N Thiamine Natural products CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 239000011149 active material Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 description 1
- 235000020661 alpha-linolenic acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 210000003056 antler Anatomy 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 229940114079 arachidonic acid Drugs 0.000 description 1
- 235000021342 arachidonic acid Nutrition 0.000 description 1
- 208000011775 arteriosclerosis disease Diseases 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 239000011425 bamboo Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000031018 biological processes and functions Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 230000004856 capillary permeability Effects 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 239000003183 carcinogenic agent Substances 0.000 description 1
- 230000007969 cellular immunity Effects 0.000 description 1
- 230000004098 cellular respiration Effects 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 231100000244 chromosomal damage Toxicity 0.000 description 1
- 210000000349 chromosome Anatomy 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000005515 coenzyme Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 210000004351 coronary vessel Anatomy 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- IZEKFCXSFNUWAM-UHFFFAOYSA-N dipyridamole Chemical compound C=12N=C(N(CCO)CCO)N=C(N3CCCCC3)C2=NC(N(CCO)CCO)=NC=1N1CCCCC1 IZEKFCXSFNUWAM-UHFFFAOYSA-N 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 150000002085 enols Chemical class 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 235000008524 evening primrose extract Nutrition 0.000 description 1
- 229940089020 evening primrose oil Drugs 0.000 description 1
- 239000010475 evening primrose oil Substances 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 201000005577 familial hyperlipidemia Diseases 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 230000004217 heart function Effects 0.000 description 1
- 208000007475 hemolytic anemia Diseases 0.000 description 1
- 230000004727 humoral immunity Effects 0.000 description 1
- 230000002218 hypoglycaemic effect Effects 0.000 description 1
- 208000021822 hypotensive Diseases 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 229940079322 interferon Drugs 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 235000020778 linoleic acid Nutrition 0.000 description 1
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 description 1
- 229960004488 linolenic acid Drugs 0.000 description 1
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 description 1
- 208000012866 low blood pressure Diseases 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000008558 metabolic pathway by substance Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000002107 myocardial effect Effects 0.000 description 1
- 210000000822 natural killer cell Anatomy 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- XKLJHFLUAHKGGU-UHFFFAOYSA-N nitrous amide Chemical compound ON=N XKLJHFLUAHKGGU-UHFFFAOYSA-N 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 235000008935 nutritious Nutrition 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000000242 pagocytic effect Effects 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- 235000019192 riboflavin Nutrition 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- 239000002151 riboflavin Substances 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 210000002027 skeletal muscle Anatomy 0.000 description 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000010902 straw Substances 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 235000007586 terpenes Nutrition 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 235000019157 thiamine Nutrition 0.000 description 1
- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 description 1
- 229960003495 thiamine Drugs 0.000 description 1
- 239000011721 thiamine Substances 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 235000021081 unsaturated fats Nutrition 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Landscapes
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention relates to a propolis genoderma spore powder Jew's ear polysaccharide composite soft capsule and its preparation process. Its main composition includes the following components: Jew's ear extract polysaccharide powder, propolis, ganoderma and pine seed oil which is used as main components, and vitamin E as auxiliary component.
Description
Technical field: the present invention relates to a kind of clever soft capsule and preparation method thereof.
Background technology: present nutraceutical is more, the overall absorption weak effect, and edible not only inconvenience but also influence absorption, and existing processing technology is coarse, can not effectively discharge the ability of the complementation of multiple nutrients material, enriched nutritive effect.
Summary of the invention: the purpose of this invention is to provide a kind of absorption that helps the person, have propolis ganoderma lucidum spore, dried black fungus polysaccharide compounded soft capsule of health care and better nutritive validity and preparation method thereof.The objective of the invention is to be achieved through the following technical solutions: the present invention is a kind of propolis ganoderma lucidum spore, dried black fungus polysaccharide compounded soft capsule, and its constituent is calculated as with 0.5 gram/grain:
Blackfungus polyhexose powder 100----150 milligram
Propolis 100----150 milligram
Lucidum spore powder 50---100 milligrams
Vitamin E 1----10 milligram
Siberian dwarf pine seed oil 100---250 milligrams
Preparation method of the present invention is: (1) will be cleaned the dry auricularia auriculajudae in back and advance mechanical crushing, granularity is controlled at about 20 orders, promptly earlier 20 purpose auricularia auriculajudae raw materials are put into container, the ethanol 90----95 degree V/V that adds 5 times of raw materials, stir, capping was soaked 1 hour, with the ethanol recover ethanol was reclaimed then; (2) the auricularia auriculajudae powder after will handling is put into basin, carries out enzymolysis processing, adds the water of 40 times of raw material weights earlier, adjusts pH value scope 4.5----5.0, heat to 50----55 degree centigrade, add pectase 1%, proteinase-10 .8%, start agitator and be mixed, enzymolysis kept 4 hours, the middle stirring 1 time; (3) water is carried: raw material slag and enzymolysis liquid directly are warmed up to 85----90 degree centigrade, kept 2.5----3.5 hour, coarse filtration: after raw material slag and extract be cooled to room temperature, carry out screen cloth coarse filtration and filter cloth earlier and filter, the filter residue list is put and is prepared for the second time that enzymolysis and water extract, for the first time filtrate to put into basin stand-by, same operation is advanced three times, both do the second time, extracted for the third time, again three leaching liquors had been lumped together, carried out next procedure; (4) smart filter: with diatomite cardboard filter machine, above-mentioned three kinds of mixed extracts are carried out essence filter, getting filtrate, to put into basin stand-by, and (5) are concentrated: use vacuum concentration pot, above-mentioned filtrate is concentrated, contain polysaccharide about 2.0 in the liquid after concentrated; (6) alcohol precipitation: with the metering of polysaccharide concentrate, add the 95%V/V ethanol of 2 times of volumes of concentrate, in alcohol precipitation under 4----10 degree centigrade the temperature about 10 hours; (7) filter: the solution behind the alcohol precipitation is carried out isolated by filtration, obtain polysaccharide precipitation, liquid reclaims by alcohol, and deposit mixes and carries out drying, promptly obtains polysaccharide; (8) drying: the polysaccharide precipitation material is carried out vacuum drying, and temperature is controlled at about 60 degree, prevents the polysaccharide sex change; (9) pulverize: the polysaccharide dry matter is put into high speed disintegrator pulverize, reach the 120----200 order and be advisable, package spare;
(11) mixing of finish: siberian dwarf pine seed oil, vitamin E are mixed; (12) slurrying is handled: pulvis intermixture and finish intermixture are mixed, handle through the mechanical agitation making beating, handle through colloidal grinding, obtain the finish mixed serum, be incubated under 50 degrees centigrade of situations, prepare next procedure and make flexible glue; (13) glue: have mixer and heating, cooling, insulation, system vacuum function in the glue jar, after the tank body sterilization, put into the steaming slide earlier and be heated to 80 degrees centigrade, add gelatin again, solid-to-liquid ratio is 1:2, add an amount of glycerine again and stir, vacuumized 4 hours, be cooled to 50 degrees centigrade, be incubated 2 hours, be put in the jar that links to each other with pellet processing machine, follow procedure starts pellet processing machine, makes soft capsule.
Formula combination of the present invention is novel unique, and the scientific basis original creation effectively improves the effect of functional component to health.The innovation of formula combination: mainly be from black fungus, to extract Blackfungus polyhexose with scientific method, be equipped with Daxing'an Mountainrange exclusive siberian dwarf pine seed oil, propolis, lucidum spore powder, vitamin E again, improved the invigoration effect of product efficacy composition, improved the absorption rate of human body to efficiency factor, improved health-care effect greatly, so this formula combination is an initiative in the health food, newly show the domestic beyond example of this combination formula through looking into.Extracting method adopts physical crushing, and the alcohol extract new technology is decomposed in the plurality of enzymes combination.The physical crushing granularity is generally about 120 orders, in order to reduce granularity, and make polysaccharide yield higher, adopt multi-enzyme method technology, main with pectase, protease, Ye Huamei etc., make grain refine, the crushed after being dried degree reaches 200 orders, to raw material yield 9.6-10.4%, adopt multiple pulvis to mix with finish, homogeneous is handled and is made soft capsule, and this technology is the innovation that single finish is made soft capsule, has the value of originality and extensive use.Make the product efficacy enhancing with five kinds of combination of active principles, strengthen absorbing of the person, strengthen health food, health care and nutrition balance, this technology is the compatibility innovation.The combination material is Blackfungus polyhexose, propolis, lucidum spore powder, siberian dwarf pine seed oil, vitamin E.Do not appear in the newspapers at home through looking into newly, fill the domestic gaps real the genus.
The specific embodiment: the present invention is a kind of propolis ganoderma lucidum spore, dried black fungus polysaccharide compounded soft capsule, and its constituent is calculated as with 0.5 gram/grain:
Blackfungus polyhexose powder 100----150 milligram
Propolis 100----150 milligram
Lucidum spore powder 50---100 milligrams
Vitamin E 1----10 milligram
Siberian dwarf pine seed oil 100---250 milligrams
Concrete constituent in the present embodiment is every 0.5 gram: Blackfungus polyhexose powder 0.1, propolis 0.1g lucidum spore powder 0.05g, vitamin E 0.001g, siberian dwarf pine seed oil 0.25g.
Preparation method of the present invention is: (1) will be cleaned the dry auricularia auriculajudae in back and advance mechanical crushing, granularity is controlled at about 20 orders, promptly earlier 20 purpose auricularia auriculajudae raw materials are put into container, the ethanol 90----95 degree V/V that adds 5 times of raw materials, stir, capping was soaked 1 hour, with the ethanol recover ethanol was reclaimed then; (2) the auricularia auriculajudae powder after will handling is put into basin, carries out enzymolysis processing, adds the water of 40 times of raw material weights earlier, adjusts pH value scope 4.5----5.0, heat to 50----55 degree centigrade, add pectase 1%, proteinase-10 .8%, start agitator and be mixed, enzymolysis kept 4 hours, the middle stirring 1 time; (3) water is carried: raw material slag and enzymolysis liquid directly are warmed up to 85----90 degree centigrade, kept 2.5----3.5 hour, coarse filtration: after raw material slag and extract be cooled to room temperature, carry out screen cloth coarse filtration and filter cloth earlier and filter, the filter residue list is put and is prepared for the second time that enzymolysis and water extract, for the first time filtrate to put into basin stand-by, same operation is advanced three times, both do the second time, extracted for the third time, again three leaching liquors had been lumped together, carried out next procedure; (4) smart filter: with diatomite cardboard filter machine, above-mentioned three kinds of mixed extracts are carried out essence filter, getting filtrate, to put into basin stand-by, and (5) are concentrated: use vacuum concentration pot, above-mentioned filtrate is concentrated, contain polysaccharide about 2.0 in the liquid after concentrated; (6) alcohol precipitation: with the metering of polysaccharide concentrate, add the 95%V/V ethanol of 2 times of volumes of concentrate, in alcohol precipitation under 4----10 degree centigrade the temperature about 10 hours; (7) filter: the solution behind the alcohol precipitation is carried out isolated by filtration, obtain polysaccharide precipitation, liquid reclaims by alcohol, and deposit mixes and carries out drying, promptly obtains polysaccharide; (8) drying: the polysaccharide precipitation material is carried out vacuum drying, and temperature is controlled at about 60 degree, prevents the polysaccharide sex change; (9) pulverize: the polysaccharide dry matter is put into high speed disintegrator pulverize, reach the 120----200 order and be advisable, package spare; (10) mixing of pulvis: Auricularia polysaccharide powder, lucidum spore powder, propolis are established material by formula rate mix, require to stir, be through sterilization treatment; (11) mixing of finish: with evening primrose oil, vitamin E, V
ASalad oil; (12) slurrying is handled: pulvis intermixture and finish intermixture are mixed, handle through the mechanical agitation making beating, handle through colloidal grinding, obtain the finish mixed serum, be incubated under 50 degrees centigrade of situations, prepare next procedure and make flexible glue; (13) glue: have mixer and heating, cooling, insulation, system vacuum function in the glue jar, after the tank body sterilization, put into the steaming slide earlier and be heated to 80 degrees centigrade, add gelatin again, solid-to-liquid ratio is 1:2, add an amount of glycerine again and stir, vacuumized 4 hours, be cooled to 50 degrees centigrade, be incubated 2 hours, be put in the jar that links to each other with pellet processing machine, follow procedure starts pellet processing machine, makes soft capsule.
The processing technology of propolis of the present invention is: (1) cleans propolis, and earlier with propolis impurity elimination dewax, (2) are cut into small pieces then.(3) dipping: ethanol and propolis are poured in the impregnating autoclave, stirred, make ethanol submergence propolis, stir later every day 1～2 time, mixture was placed for 2 weeks in warm place lucifuge.(4) filter: after flooding for two weeks, liquid is filtered 2 times with 100 order filter clothes.(5) drying: adopt spray drying process to carry out drying.(6) check: through the product warehousing that is up to the standards.
The processing technology of lucidum spore powder of the present invention is: (1) cleans: remove non-glossy ganoderma impurity.(2) cutting: will clean qualified glossy ganoderma and be cut into small pieces.(3) drying: glossy ganoderma gone in the hot air circulation drying oven carry out drying with 60 ℃～65 ℃, moisture is being qualified below 6%.(4) pulverize: adopt a times power pulverizer to pulverize.(5) check: microscopic examination, grinding particle size: medium particle diameter is qualified below 5～10 μ m.(6) warehouse-in: product warehousing is up to the standards.
Prescription of the present invention main according to be＜＜Pharmacopoeia of People's Republic of China, " centre halfback No. 2002.51 " file of issuing of health ministry in the pertinent regulations of the nutraceutical of instant also medicine and health food,＜＜Chinese health food progress etc., ad hoc meter formula for a product.
One, Blackfungus polyhexose
Blackfungus polyhexose is to be raw material with the black fungus that northeast abounds with, the Blackfungus polyhexose material that extracts by scientific method.
The biological character of black ear: black fungus, be called for short auricularia auriculajudae, Basidiomycetes, Auriculariaceae, the fructification of Auricularia has another name called black dish, mulberry ear, and another names such as wood fungus, tree chicken, wooden moth, wooden young pilose antler are arranged again, belongs to wild edible fungus.Be born on the rotten wood such as fried, mulberry, ashamed, willow, elm, ancient times is called five auricularia auriculajudaes.Black fungus is a kind of saprophytic fungus of warm nature, relies on the dried growth and breeding of straw of broad leaf tree.Heilungkiang is the township that abounds with natural black fungus, the mountain area around the Daxing'an Mountainrange, the Xiaoxinanlin Mountains particularly, abound with the natural and pollution-free green black fungus, big nutritious, the delicious flavour of thick of fine quality, ear, contain protein, Auricularia polysaccharide, multivitamin and trace element, be subjected to the welcome and the favor in broad masses and restaurant especially deeply.
The effective ingredient of black fungus: black fungus meat exquisiteness, tender deliciousness, main is that black fungus contains rich in protein, protein content 10.6g/100g in dry product, carbohydrate 65g/100g, wherein more than the Auricularia polysaccharide 2000mg/100g, fatty 0.2g/100g, calcium 357mg/100g, phosphorus 201mg/100g, iron 185mg/100g (higher 13 times than egg) also have quite high Hu square-bottomed bamboo basket Bu Su, thiamine, riboflavin, niacin, phosphatide, sterol, VB
1, VB
2, PP etc., and contain more colloid, the effect of extraordinary blood-enrich, moistening lung calmness, gut purge are arranged, washing intestines.
The health care of black fungus: modern scientific research shows that auricularia auriculajudae has the effect of platelet aggregation-against, and can reduce the cholesterol level in the blood.Auricularia auriculajudae can be improved the phagocytic index and the percentage of mouse macrophage, to 60C
0The animal of irradiation can be improved its survival rate, proves radiation resistance, and the caused leucocyte of chemicals that can resist because of the treatment tumour descends, and auricularia auriculajudae can also promote the biosynthesis of albumen in the mice serum.Owing to contain more Auricularia polysaccharide and materials such as colloid, vitamin in the auricularia auriculajudae, the mankind had the effect that reduces blood sugar, blood fat, fat-reducing is arranged.
Two, propolis: propolis is universally acknowledged nutrient and healthcare products.Propolis is later owing to what it is found that, and development and use are especially because of biological purification technique of modern times just is achieved, so a lot of people may be also stranger to propolis.The Chinese and foreign department scholar saying through the back praise of concentrating on studies, and propolis is perfect natural broad-spectrum antibiotics; It is innate immunity reinforcing agent; Be the street cleaner of blood vessel; Be healthy patron saint; It is natural antioxidant ...Become magical propolis through the modern science and technology analysis, the elite of propolis collection animals and plants, composition is very complicated, multiple very strong physiological activator is wherein arranged, as flavonoids, phenols, terpenes, organic acid and several amino acids, enzyme, vitamin, mineral matter etc.Oxonian researcher finds, in contained more than the 200 kind of composition of propolis, have 100 surplus the natural crude drug composition of kind, so there is the people to say, propolis similarly is one " a little Drug Storage ".As aspect antibiotic, the antioxidation, propolis is used for the storing and fresh-keeping of muscle, liver, kidney and other tissue, no abnormal variation in six months.The aqueous solution that propolis is mixed with concentration lower (0.03%) is used for fruit freshness preserving, and percentage of water loss, decayed fruit rate all reduce greatly after 147 days.Propolis has very strong antibacterial, sterilizing ability, but it and synthetics have the difference of essence, and its Nantural non-toxic is not only effectively gentle, and has no side effect, and is described as the most perfect antibiotics by scientist.Flavone compound in the propolis and various active composition can make ATP increase, and discharge the energy that the more mankind depend on for existence.Enough ATP are arranged in the cell, just tired material such as lactic acid and other toxic metabolites can be excreted smoothly, make people's relaxation and happiness, be difficult for old and feeble and sick.These material compositions also can effectively reduce capillary permeability, prevent vascular sclerosis, improve microcirculation, but and reducing blood lipid, hypoglycemic, hypotensive, the prevention various diseases.Evidence, propolis can strengthen body immunity effectively, promotes cytophagous effect, stimulates health to produce antibody, is a kind of innate immunity reinforcing agent of preciousness.Nowadays, propolis has been widely used in many fields such as medicine, health care, cosmetics.
Three, seed of Dwarf Siberian Pine oil: the siberian dwarf pine seed is the peculiar resource of Daxinganling District, is grown in 800 meters mountain tops of height above sea level.Therefore the siberian dwarf pine fruit claims fruit on the thousand again because of 1,000 genius results.Seed of Dwarf Siberian Pine oil contains more than the 100 kind of composition to the human body beneficial, is rich in multiple unrighted acids such as phosphatide, vitamin E, vegetable protein, linoleic acid, leukotrienes and arachidonic acid, easily is the absorption of human body utilization.Have the U.S. face of brain tonic and intelligence development, anti-ageing life-prolonging, skin moisten, relax bowel, reduce cholesterol level in the blood, prevent artery sclerosis, reducing blood lipid, hypotensive effect.Abundant linoleic acid, leukotrienes, acid and gamma-linolenic have the effect of extraordinary reduction cholesterol and triglyceride.Aspect the inhibition vessel retraction, pine-seed oil is premier in addition.In a single day blood vessel shrinks, and blood vessel will narrow down, and blood pressure will raise.Hypertension can cause various dysfunctions, and this point is well-known.Because contain a large amount of Pinolenic acids in the seed of Dwarf Siberian Pine oil, it can reduce the concentration of blood cholesterol and triglyceride, and can suppress the harmful effect of diabetes to human body; Regulate water-electrolyte metabolism and bring high blood pressure down; Suppress the damage of radical pair human body, it can also promote the release of interferon and lymphocyte factor in addition, and activation NK cell kills, suppresses cancer cell, so it also has anticancer effect, can prevent chromosomal damage; Anti-ageing, reduce the accumulation of the fat that causes by alcohol at liver.Moreover, the unique advantage of its maximum also is its unrighted acid position difference, can not become other harmful substances in human body, because it has overcome the secondary face sound of other unrighted acid to human body, therefore, can eliminate the adverse effect of linoleic acid plus linolenic acid to human body.If we eat a certain amount of pine nut or pine-seed oil every days, your physique can be improved at all so, and healthy meeting accompanies you lifelong.
Four, glossy ganoderma: glossy ganoderma ancient books record glossy ganoderma " food of a specified duration is made light of one's life by commiting suicide not old, prolongs life ".Glossy ganoderma is the diastole coronary artery effectively, increase coronary blood flow, improve myocardium microcirculation, increase myocardial oxygen delivery, can be used for coronary heart disease, anginal treatment and prevention, glossy ganoderma can be regulated nervous centralis, improve end artery sclerosis, the reinforcement cardiac function of blood vessel slightly, softening blood vessel has two-way corrective action to blood pressure: reduce hypertension, the rising low blood pressure.To hyperlipemia, can prevention of arterial AP form, and can purify the blood, prevent and dissolve thrombus.These functions have good preventive and therapeutic effect for polytype apoplexy.Glossy ganoderma has the characteristics of " dietotherapeutic " from ancient times, and its attribute of " strengthening the body resistance to consolidate the constitution " has determined it can help the human righteousness, and glossy ganoderma is improved the immunocompetence of human body from cellular immunity and humoral immunity two aspects, strengthened the resistivity to disease.Moisture of skin can be regulated and keep to glossy ganoderma, recovers melanic telogenesis and precipitation in the skin.Glossy ganoderma also can make complexion fine and glossy glossy, i.e. ancient book contained " good color ".
Five, vitamin E: the form of vitamin E tool activity has 8 kinds, and promptly residual acid is in enol, but to remain alcohol, it represents vitamin E.Vitamin E is a kind of Polyphenols, and very strong antioxidation is arranged, and resists body peroxidating product free radical damage, becomes topmost active material in the health care for the aged food.
Can stop fat oxidation in food and the alimentary canal as antioxidant, the protection human body cell is avoided the toxicant injury that the unsaturated fat acid oxidase produces.Vitamin E self is prior to other material generation oxidations in vivo, thereby makes unrighted acid and vitamin A oxidation Decomposition in enteron aisle and tissue reduce to minimum degree.The biological action of vitamin E is to suppress polyunsaturated fatty acid oxidation in the tissue film, the lipid part of stabilized cell, and the protection cell is not subjected to poisonous free radical injury, prevents to wear out, and prevents organic trace to move back the aspect and works.Vitamin E can be treated hemolytic anemia as the necessary factor of protection red blood cell integrality in addition; As the necessary factor of cellular respiration, be that cardiac muscle and skeletal muscle tissue are breathed desired material, as the synthetic conditioning agent of compound in the body, participate in the synthetic of DNA, also may be the synthetic confactor of vitamin C and coenzyme; Exempt from air-polluting as the protection lung tissue and ruin agent, vitamin E can also act synergistically with iodine, and vitamin E and iodine all are antioxidants, but both action pathway differences.
Vitamin E has protective effect on cancer risk, can prevent that chromosome from very becoming, and strengthens the activity of particulate mixed-function oxidase, influences the carcinogenic substance metabolism, and blocking nitrosamine formation is synthetic etc., thereby can give protection against cancer.Can strengthen the effect of DHA and EPA.Behind the science combination formula, have excellent cleaning blood vessel, regulate the effect of blood fat.
Claims (2)
1, a kind of propolis ganoderma lucidum spore, dried black fungus polysaccharide compounded soft capsule is characterized in that:
Blackfungus polyhexose powder 100----150 milligram
Propolis 100----150 milligram
Lucidum spore powder 50---100 milligrams
Seed of Dwarf Siberian Pine oil 100---250 milligrams
Vitamin E 1----10 milligram
2,
It is characterized in that: (1) will be cleaned the dry auricularia auriculajudae in back and advance mechanical crushing, and granularity is controlled at about 20 orders, promptly earlier 20 purpose auricularia auriculajudae raw materials is put into container, the ethanol 90----95 degree V/V that adds 5 times of raw materials, stir, capping was soaked 1 hour, with the ethanol recover ethanol was reclaimed then; (2) the auricularia auriculajudae powder after will handling is put into basin, carries out enzymolysis processing, adds the water of 40 times of raw material weights earlier, adjusts pH value scope 4.5----5.0, heat to 50----55 degree centigrade, add pectase 1%, proteinase-10 .8%, start agitator and be mixed, enzymolysis kept 4 hours, the middle stirring 1 time; (3) water is carried: raw material slag and enzymolysis liquid directly are warmed up to 85----90 degree centigrade, kept 2.5----3.5 hour, coarse filtration: after raw material slag and extract be cooled to room temperature, carry out screen cloth coarse filtration and filter cloth earlier and filter, the filter residue list is put and is prepared for the second time that enzymolysis and water extract, for the first time filtrate to put into basin stand-by, same operation is advanced three times, both do the second time, extracted for the third time, again three leaching liquors had been lumped together, carried out next procedure; (4) smart filter: with diatomite cardboard filter machine, above-mentioned three kinds of mixed extracts are carried out essence filter, getting filtrate, to put into basin stand-by, and (5) are concentrated: use vacuum concentration pot, above-mentioned filtrate is concentrated, contain polysaccharide about 2.0 in the liquid after concentrated; (6) alcohol precipitation: with the metering of polysaccharide concentrate, add the 95%V/V ethanol of 2 times of volumes of concentrate, in alcohol precipitation under 4----10 degree centigrade the temperature about 10 hours; (7) filter: the solution behind the alcohol precipitation is carried out isolated by filtration, obtain polysaccharide precipitation, liquid reclaims by alcohol, and deposit mixes and carries out drying, promptly obtains polysaccharide; (8) drying: the polysaccharide precipitation material is carried out vacuum drying, and temperature is controlled at about 60 degree, prevents the polysaccharide sex change; (9) pulverize: the polysaccharide dry matter is put into high speed disintegrator pulverize, reach the 120----200 order and be advisable, package spare; (10) mixing of pulvis: Auricularia polysaccharide powder, lucidum spore powder, propolis are established material by formula rate mix, require to stir, be through sterilization treatment; (11) mixing of finish: siberian dwarf pine seed oil, vitamin E are mixed; (12) slurrying is handled: pulvis intermixture and finish intermixture are mixed, handle through the mechanical agitation making beating, handle through colloidal grinding, obtain the finish mixed serum, be incubated under 50 degrees centigrade of situations, prepare next procedure and make flexible glue; (13) glue: have mixer and heating, cooling, insulation, system vacuum function in the glue jar, after the tank body sterilization, put into the steaming slide earlier and be heated to 80 degrees centigrade, add gelatin again, solid-to-liquid ratio is 1:2, add an amount of glycerine again and stir, vacuumized 4 hours, be cooled to 50 degrees centigrade, be incubated 2 hours, be put in the jar that links to each other with pellet processing machine, follow procedure starts pellet processing machine, makes soft capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100097464A CN100488381C (en) | 2006-02-27 | 2006-02-27 | Propolis ganoderma lucidum spore, dried black fungus polysaccharide compounded soft capsule and preparing process therefor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100097464A CN100488381C (en) | 2006-02-27 | 2006-02-27 | Propolis ganoderma lucidum spore, dried black fungus polysaccharide compounded soft capsule and preparing process therefor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1850126A CN1850126A (en) | 2006-10-25 |
| CN100488381C true CN100488381C (en) | 2009-05-20 |
Family
ID=37131638
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2006100097464A Expired - Fee Related CN100488381C (en) | 2006-02-27 | 2006-02-27 | Propolis ganoderma lucidum spore, dried black fungus polysaccharide compounded soft capsule and preparing process therefor |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100488381C (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103262973A (en) * | 2013-04-24 | 2013-08-28 | 张�荣 | Auricularia auricula polysaccharide-pine nut oil composite soft-capsule |
| CN105919073A (en) * | 2016-04-25 | 2016-09-07 | 孙继勇 | Vacant plant capsules made from wall-breaking glossy ganoderma spore powder and making method of vacant plant capsules |
| CN106616185A (en) * | 2017-01-04 | 2017-05-10 | 云南农业大学 | Processing process of health type coix seed solid beverage |
| CN113115948A (en) * | 2019-12-30 | 2021-07-16 | 黑龙江北货郎森林食品有限公司 | A health food containing Auricularia auricula polysaccharide and its preparation method |
-
2006
- 2006-02-27 CN CNB2006100097464A patent/CN100488381C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1850126A (en) | 2006-10-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR101054041B1 (en) | Manufacturing method and composition for mass processing fermented products and fermented extracts using Hwangchil wood | |
| JP5667358B2 (en) | Aspergillus fermented composition of citrus peel | |
| CN102242070B (en) | Method for artificially culturing paecilomyces cicadae and application of culturing product thereof | |
| CN103609865B (en) | Pollution-free livestock and poultry feed additive using ginkgo leaves as base stock | |
| CN1404751A (en) | Health-care vermicelli, bean-made noodles and bean-made sheet jelly | |
| KR101723206B1 (en) | Pills for health supplement food comprising extracts of protaetia brebitarsis larba and manufacturing method for the same | |
| CN1569123A (en) | Oral functional Chinese medicine intensified by snake, bee, macroelement and microelement and its preparation | |
| CN106255421B (en) | Method for producing garlic fermented composition and garlic fermented composition | |
| CN1791419A (en) | Remedy | |
| CN100488381C (en) | Propolis ganoderma lucidum spore, dried black fungus polysaccharide compounded soft capsule and preparing process therefor | |
| CN106614306B (en) | A kind of chicken method for breeding | |
| CN103432059B (en) | Loranthus kaempferi paste egg white mask | |
| CN106138101A (en) | A kind of preparation method of Embryo Gallus domesticus extract | |
| CN106588228A (en) | Culture medium material capable of increasing carotene content of black fungi | |
| CN106165739A (en) | The manufacture method of the LIUPUCHA of dental caries can be prevented and treated | |
| KR20160059137A (en) | MANUFACTURE OF FERMENTED Alliumhookeri FROM LACTIC ACID BACTERIA AND NATURAL ENZYME AND PREPARATION OF COMBINED BEVERAGE FOR QUENCHING THIRST | |
| CN109937795B (en) | Method for cultivating cordyceps sinensis mycelia by taking jasmine as matrix | |
| CN108077936A (en) | A kind of Seabuckthorn Oil Spirulina soft capsule and preparation method thereof | |
| CN108850571A (en) | A kind of crisp shape of the mouth as one speaks cattle feed and preparation method thereof | |
| CN100450493C (en) | Black fungus composite soft capsule and its preparing process | |
| CN105853335A (en) | Skin moisturizer made from snake and traditional Chinese medicine extracts | |
| CN105331511A (en) | Grape and winged yam rhizome vinegar | |
| CN104323970A (en) | Chinese fir parasitic cream-egg white mask | |
| JP3779740B2 (en) | Agents for preventing and treating obesity from rice | |
| CN108456613A (en) | A kind of health care's wine and its preparation method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20090520 Termination date: 20100227 |