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CN100482293C - Slow release type remote controlled electronic capsule - Google Patents

Slow release type remote controlled electronic capsule Download PDF

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Publication number
CN100482293C
CN100482293C CNB2006100953084A CN200610095308A CN100482293C CN 100482293 C CN100482293 C CN 100482293C CN B2006100953084 A CNB2006100953084 A CN B2006100953084A CN 200610095308 A CN200610095308 A CN 200610095308A CN 100482293 C CN100482293 C CN 100482293C
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hole
circular
drug
remote control
release
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CN100998904A (en
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皮喜田
刘洪英
陈锋
郑小林
温志渝
彭承琳
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Chongqing University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time

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Abstract

缓释型遥控电子胶囊，涉及一种向消化道中释放物质的装置，用于在动物或人体的消化道遥控缓释放物质，如药物、食物、标记物等，包括胶囊外壳、遥控驱动机构、药物释放通道机构，所述的缓释型遥控电子胶囊包括一个固体药物片芯，该药物片芯包含了待释放药物，药物片芯的一端的表面具有至少一个圆柱体形或者圆锥体形的凸起机构，所述凸起机构正对于药物释放通道机构，遥控驱动机构接收到外界发出的遥控信号后，产生一个驱动力，驱动力迫使药物片芯向一端运动，凸起机构在驱动力的作用下打开药物释放通道机构，药物缓慢释放入消化道。本发明弥补了以往遥控电子胶囊只能一次性快速释放药物的缺点，具备了缓释功能，而且结构简单，易于批量生产。

Figure 200610095308

The slow-release remote-controlled electronic capsule relates to a device for releasing substances into the digestive tract, which is used to remotely and slowly release substances in the digestive tract of animals or humans, such as drugs, food, markers, etc. The release channel mechanism, the slow-release remote control electronic capsule includes a solid drug tablet core, the drug tablet core contains the drug to be released, and the surface of one end of the drug tablet core has at least one cylindrical or conical convex mechanism, The protruding mechanism is facing the drug release channel mechanism, and the remote control driving mechanism generates a driving force after receiving the remote control signal from the outside world, and the driving force forces the drug tablet core to move to one end, and the protruding mechanism opens the drug tablet under the action of the driving force. Release channel mechanism, the drug is slowly released into the digestive tract. The invention makes up for the shortcoming of the previous remote control electronic capsules that can only quickly release medicine at one time, has the function of sustained release, and has a simple structure and is easy to produce in batches.

Figure 200610095308

Description

Slow release type remote controlled electronic capsule
Technical field:
The present invention relates to a kind of slow release type remote controlled electronic capsule, particularly a kind of device that discharges medicine in digestive tract is used for putting material at the digestive tract remote control slow release of animal or human's body, as medicine, food, label etc.
Background technology:
Remote controlled electronic capsule is a kind of drug delivery system based on the micromechanics electronic technology, can be by external remote control, and the control medicine has excellent application value in gastral release time and off-position aspect clinical treatment, the medicine digestive tract Absorption Study.In Chinese patent CN200410040809.3, among the ZL02128141.6, the scheme of remote controlled electronic capsule is all disclosed, but such scheme all can only disposablely be gone into digestive tract with the medicine rapid release, the problem that this release mode exists is: disposable drug release is gone in the digestive tract, the medicine fast Absorption, form the drug absorption peak easily, the blood substance concentration that this raises suddenly, be easy to generate side effect, for obtaining good therapeutic effect, a lasting metastable drug release rate is very important.
Summary of the invention:
The objective of the invention is to overcome the deficiencies in the prior art, the slow release type remote controlled electronic capsule with slow-release function is provided, when having external distant control function, realize that medicine discharges with speed comparatively slowly in digestive tract.
Technical scheme of the present invention is: a kind of slow release type remote controlled electronic capsule, comprise capsule shell, the remote control driving mechanism, the drug release passage mechanism, comprise a solid drugs label in the described slow release type remote controlled electronic capsule, this medicine label has comprised medicine to be discharged, the surface of one end of medicine label has the protrusion means of at least one cylinder bodily form or cone shape, protrusion means is water-soluble material or is made with medicine label identical materials, described protrusion means is right against the drug release passage mechanism, channel diameter after the drug release passage mechanism is opened is greater than the diameter of protrusion means, the medicine label is done as a wholely can not pass through the drug release passage mechanism, after the remote control driving mechanism receives the remote signal of sending in the external world, produce a driving force, driving force puts on the medicine label, the medicine label is to the end motion with drug release passage mechanism, and protrusion means is opened the drug release passage mechanism under the effect of driving force.
Drug release passage mechanism in the technical solution of the present invention can be in following three kinds of schemes any one:
1. an end of the shell of described slow release type remote controlled electronic capsule has one or more manhole, the diameter of manhole is between 0.5mm-6mm, the length of through hole is between 0.5mm-5mm, be plugged with sealing-plug in the through hole, sealing-plug constitutes airtight the cooperation with the wall of through hole, the frictional force of sealing-plug and through-hole wall is between 1-5 newton, and sealing-plug and through hole constitute the drug release passage mechanism of slow release type remote controlled electronic capsule.Has the protrusion means that equates with number of openings on the medicine label, the length of protrusion means is not more than the length of through hole, protrusion means is cylinder or the cone of diameter less than through hole, and the protrusion means on the medicine label is over against through hole and dead in line, after the remote control driving mechanism receives the remote signal of sending in the external world, produce driving force, driving force puts on the medicine label, and the medicine label moves to through hole end, and protrusion means is inserted through hole, and with the sealing-plug release, thereby open passage mechanism.
2. on the end of the shell of described slow release type remote controlled electronic capsule one or more manhole is arranged, the diameter of manhole is between 0.5mm-6mm, the length of through hole is between 0.5mm-5mm, the inner surface that the slow release type remote controlled electronic capsule shell has manhole one end is fixed with the diaphragm seal of thickness less than 0.3mm, diaphragm seal constitutes airtight the cooperation with through hole, diaphragm seal and through hole constitute the drug release passage mechanism of slow release type remote controlled electronic capsule, protrusion means on the medicine label is the cylinder of diameter less than through hole, perhaps cone, protrusion means on the medicine label is over against through hole and dead in line, after the remote control driving mechanism receives the remote signal of sending in the external world, produce a driving force, driving force puts on the medicine label, the medicine label moves to through hole end, protrusion means is inserted through hole, puncture diaphragm seal, thereby open passage mechanism.
3. on the end of the shell of described slow release type remote controlled electronic capsule one or more manhole is arranged, the diameter of manhole is between 0.5mm-6mm, the length of through hole is between 0.5mm-5mm, the inner surface that the slow release type remote controlled electronic capsule shell has manhole one end is fixed with the diaphragm seal of thickness less than 0.3mm, diaphragm seal constitutes airtight the cooperation with through hole, be plugged with sealing-plug in the through hole, sealing-plug constitutes airtight the cooperation with the wall of through hole, the frictional force of sealing-plug and through-hole wall is between 1-5 newton, diaphragm seal, sealing-plug constitutes the drug release passage mechanism of slow release type remote controlled electronic capsule with through hole, protrusion means on the medicine label is the cylinder of diameter less than through hole, perhaps cone, protrusion means on the medicine label is over against through hole and dead in line, after the remote control driving mechanism receives the remote signal of sending in the external world, produce a driving force, driving force puts on the medicine label, the medicine label moves to through hole end, protrusion means is inserted through hole, puncture diaphragm seal, and with the sealing-plug release, thereby open passage mechanism.
Work process of the present invention and principle are: described slow release type remote controlled electronic capsule is swallowed and is entered after the digestive tract, user is by methods such as location tracking or Time Calculation, determine when the triggering electronic capsule, after user sends drug release remote controlled signal, after remote control driving mechanism in the slow release type remote controlled electronic capsule receives the remote signal of sending in the external world, produce a driving force, be generally the spring that discharges a compression, driving force puts on the medicine label, the medicine label is to an end motion, protrusion means is opened the drug release passage mechanism under the effect of driving force, for example sealing-plug is pushed away shell, perhaps diaphragm seal is punctured, protrusion means contacts with digestive tract, protrusion means is dissolved by digestive tract liquid gradually, subsequently, the medicine label communicates with digestive tract by the drug release passage mechanism, the medicine label dissolves gradually, because the medicine of medicine label disintegrate can only communicate with digestive tract by through hole, size by the control through hole, as control the diameter and the length of through hole, thereby can form the medicament slow release of different rates of release.
The present invention compared with prior art has following technique effect:
1, has slow-release function.The present invention not only possesses external drug release remote controlled function, can also realize the slow release of medicine simultaneously, realizes drug level more stably.
2, structure is simplified, and is easy to produce in batches.The present invention has realized the medicament slow release function by the modular design of medicine label and drug release passage mechanism by simple structure, has good practicality, is easy to produce in batches.
Description of drawings:
Fig. 1 is the composition sketch map of slow release type remote controlled electronic capsule of the present invention.
Fig. 2 is the composition sketch map with slow release type remote controlled electronic capsule of plug construction.
Fig. 3 is that the drug release passage mechanism with slow release type remote controlled electronic capsule of plug construction is opened sketch map.
Fig. 4 is the drug release process sketch map with slow release type remote controlled electronic capsule of plug construction.
Fig. 5 is the structural representation after medicine with slow release type remote controlled electronic capsule of plug construction discharges fully.
Fig. 6 is the slow release type remote controlled electronic capsule structural representation with two protrusion means.
Fig. 7 is the composition sketch map with slow release type remote controlled electronic capsule of seal diaphragm structure.
Fig. 8 is that the drug release passage mechanism with slow release type remote controlled electronic capsule of seal diaphragm structure is opened sketch map.
Fig. 9 is the drug release process sketch map with slow release type remote controlled electronic capsule of seal diaphragm structure.
Figure 10 is the structural representation after medicine with slow release type remote controlled electronic capsule of seal diaphragm structure discharges fully.
Figure 11 is the slow release type remote controlled electronic capsule structural representation with three protrusion means.
Figure 12 is the composition sketch map that has the slow release type remote controlled electronic capsule of diaphragm seal and plug construction simultaneously.
Figure 13 is the directly oral drug level time plot of going in the beasle dog digestive tract of medicine label.
Figure 14 is the drug level time plot of slow release type remote controlled electronic capsule in the beasle dog digestive tract.
In Fig. 1 to Figure 14:
1-capsule shell, 2-remote control driving mechanism, 3-medicine label, 4-protrusion means, 5-through hole,
6-sealing-plug, 7-battery, 8-circuit module, 9-heating resistor, 10-nylon wire,
The 11-spring, 12-drive plate, 13-driving mechanism shell, 14-intestinal, 15-diaphragm seal.
The specific embodiment:
Embodiment 1:
The slow release type remote controlled electronic capsule of present embodiment, comprise capsule shell 1, remote control driving mechanism 2, one end of capsule shell 1 has the through hole 5 of a circle, and the diameter of through hole 5 is 3mm, and the length of through hole 5 is 2mm, be plugged with sealing-plug 6 in the through hole, sealing-plug 6 constitutes airtight the cooperation with the wall of through hole 5, and sealing-plug 6 is 3 newton with the frictional force of through hole 5, and sealing-plug 6 and through hole 5 constitute the drug release passage mechanism of slow release type remote controlled electronic capsules.The manufactured materials of capsule shell 1 is the Merlon with good biocompatibility, and the manufactured materials of sealing-plug 6 is the silicone rubber with good biocompatibility.
Slow release type remote controlled electronic capsule in the present embodiment comprises a solid drugs label 3, medicine label 3 is the cylinder of diameter 8mm, this medicine label 3 has comprised medicine to be discharged, the surface of one end of medicine label 3 has a protrusion means 4, protrusion means 4 is made for water-soluble material or with medicine label identical materials, the diameter of described protrusion means 4 maximums is 2mm, is right against through hole 5.
Comprise battery 7, circuit module 8, heating resistor 9, nylon wire 10, spring 11, drive plate 12, driving mechanism shell 13 in the remote control driving mechanism 2.Spring 11 is fixed by nylon wire 10, is in compressive state, and nylon wire 10 closely contacts with heating resistor 9.In use, electronic capsule is swallowed after the digestive tract, after remote signal launched in external remote control unit, after circuit module 8 receives the remote signal of sending in the external world, connect circuit, battery 7 is to heating resistor 9 power supplies, heating resistor 9 temperature raise rapidly, fusing nylon wire 10, and the spring 11 of compressive state is released, produce a driving force, driving force puts on the medicine label 3 by drive plate 12, and medicine label 3 is to the end motion with drug release passage mechanism, and protrusion means 4 is inserted through hole 5 under the effect of driving force, and with sealing-plug 6 releases, thereby open the drug release passage mechanism.
Protrusion means 4 at first contacts with digestive tract liquid, because protrusion means 4 is made for water-soluble material or with medicine label 3 identical materials, so protrusion means 4 disintegrate gradually, dissolve, after protrusion means 4 disintegrates, medicine label 3 communicates by through hole 5 and digestive tract liquid, and disintegrate gradually, medicine is discharged in the digestive tract by through hole 5 gradually, because the pressure effect of spring 11, medicine label 3 keeps relatively-stationary position relation with through hole 5 all the time, thereby obtains comparatively stable drug release rate.
Fig. 2 has provided the structural representation of present embodiment before drug release.
Fig. 3 is that the drug release passage mechanism that has provided present embodiment is opened sketch map.
Fig. 4 is the drug release process sketch map of present embodiment.
Fig. 5 is the structural representation after the medicine of the slow release type remote controlled electronic capsule of present embodiment discharges fully, can find out among the figure, after medicine discharges fully, drive plate 12 is under the effect of spring 11, with through hole 5 sealings, prevent that digestive tract liquid from entering capsule, avoids the electronic devices and components of digestive tract liquid corrosion capsule.In the present embodiment, drive plate 12 is made for the silicone rubber with good biocompatibility, and thickness is 2mm, and diameter is 6mm, in the design, must guarantee the diameter of the diameter of drive plate 12 greater than through hole 5, to guarantee good sealing.
In order to verify the actual effect of embodiment, carried out serial contrast test.For the slow release effect that the structural design of verifying present embodiment produces, in the test, the medicine label has adopted 400mg aminophylline powder compaction to form, and does not wherein add any other adjuvant.Battery of tests is the medicine label that adopts 12 400mg, and directly per os is sent into the digestive tract of 12 beasle dogs, according to the pharmacokinetics flow process of standard, gathers animal blood, obtains average drug level time graph, as shown in figure 13.Battery of tests is the slow release type remote controlled electronic capsule that adopts present embodiment in addition, the medicine label is packaged in the electronic capsule, utilize conduit electronic capsule to be sent in the digestive tract of 12 beasle dogs, then by external remote control drug release, obtain average drug level time graph, as shown in figure 14.Two groups of data contrasts as can be known, direct oral aminophylline medicine label, medicine is being swallowed between back 2-4 hour, there is tangible drug level peak value, be to decay fast then, and utilize the slow release type remote controlled electronic capsule of present embodiment that drug concentrations changes mild relatively, still had suitable drug level later at 18 hours, illustrated that present embodiment has the effect of medicament slow release.Test has illustrated that simultaneously the reason of the slow release effect of medicine is the design of the drug release passage mechanism of present embodiment, rather than the slow release effect of medicine label itself, can infer with this, for other drug, also has similar effects, if the user can obtain desired drug release effect by the structure and composition design of further medicine label.
Embodiment 2:
The primary structure of present embodiment is identical with embodiment 1, difference is: an end of capsule shell 1 has the through hole 5 of 2 circles, the diameter of through hole 5 is 2mm, the length of through hole 5 is 2mm, be plugged with sealing-plug 6 respectively in two through holes 5, sealing-plug 6 constitutes airtight the cooperation with the wall of through hole 5, and the frictional force of sealing-plug 6 and through hole 5 is between the 2-3 newton, and sealing-plug 6 and through hole 5 constitute the drug release passage mechanism of slow release type remote controlled electronic capsules.The surface of one end of the medicine label 3 in the present embodiment has two protrusion means 4, protrusion means 4 is made for water-soluble material or with medicine label identical materials, the diameter of described protrusion means 4 maximums is 1.5mm, respectively over against being right against two through holes 5.
Fig. 6 has provided the slow release type remote controlled electronic capsule structural representation of present embodiment.
Embodiment 3:
The slow release type remote controlled electronic capsule of present embodiment, comprise capsule shell 1, remote control driving mechanism 2, one end of capsule shell 1 has the through hole 5 of a circle, the diameter of through hole 5 is 4mm, and the length of through hole 5 is 3mm, and the inner surface of through hole 5 is fixed with the diaphragm seal 15 that thickness is 0.2mm, diaphragm seal 15 constitutes airtight the cooperation with through hole 5, and diaphragm seal 15 and through hole 5 constitute the drug release passage mechanism of slow release type remote controlled electronic capsules.The manufactured materials of capsule shell 1 is the Merlon with good biocompatibility, the silicon rubber film of diaphragm seal 15 for having better elastic.
Slow release type remote controlled electronic capsule in the present embodiment comprises a solid drugs label 3, medicine label 3 is the cylinder of diameter 8mm, this medicine label 3 has comprised medicine to be discharged, the surface of one end of medicine label 3 has a protrusion means 4, protrusion means 4 is made for water-soluble material or with medicine label identical materials, the diameter of described protrusion means 4 maximums is 3mm, is right against through hole 5.
Comprise battery 7, circuit module 8, heating resistor 9, nylon wire 10, spring 11, drive plate 12, driving mechanism shell 13 in the remote control driving mechanism 2.Spring 11 is fixed by nylon wire 10, is in compressive state, and nylon wire 10 closely contacts with heating resistor 9.In use, electronic capsule is swallowed after the digestive tract, after remote signal launched in external remote control unit, after circuit module 8 receives the remote signal of sending in the external world, connect circuit, battery 7 is to heating resistor 9 power supplies, heating resistor 9 temperature raise rapidly, fusing nylon wire 10, and the spring 11 of compressive state is released, produce a driving force, driving force puts on the medicine label 3 by drive plate 12, and medicine label 3 is to the end motion with drug release passage mechanism, and protrusion means 4 is inserted through hole 5 under the effect of driving force, puncture diaphragm seal 15, thereby open passage mechanism.
Protrusion means 4 at first contacts with digestive tract liquid, because protrusion means 4 is made for water-soluble material or with medicine label 3 identical materials, so protrusion means 4 disintegrate gradually, dissolve, after protrusion means 4 disintegrates, medicine label 3 communicates by through hole 5 and digestive tract liquid, and disintegrate gradually, medicine is discharged in the digestive tract by through hole 5 gradually, because the pressure effect of spring 11, medicine label 3 keeps relatively-stationary position relation with through hole 5 all the time, thereby obtains comparatively stable drug release rate.
Fig. 7 has provided the structural representation of present embodiment before drug release.
Fig. 8 is that the drug release passage mechanism that has provided present embodiment is opened sketch map.
Fig. 9 is the drug release process sketch map of present embodiment.
Figure 10 is the structural representation after the medicine of the slow release type remote controlled electronic capsule of present embodiment discharges fully, can find out among the figure, after medicine discharges fully, drive plate 12 is under the effect of spring 11, with through hole 5 sealings, prevent that digestive tract liquid from entering capsule, avoids the electronic devices and components of digestive tract liquid corrosion capsule.
Embodiment 4:
The primary structure of present embodiment is identical with embodiment 3, difference is: an end of capsule shell 1 has the through hole 5 of 3 circles, the diameter of through hole 5 is 1.5mm, the length of through hole 5 is 1.5mm, the inner surface of through hole 5 is fixed with the diaphragm seal 15 that thickness is 0.1mm, diaphragm seal 15 constitutes airtight the cooperation with through hole 5, the drug release passage mechanism of diaphragm seal 15 and three through hole 5 formation slow release type remote controlled electronic capsules.
The surface of one end of the medicine label 3 among the wood embodiment has three protrusion means 4, protrusion means 4 is made for water-soluble material or with medicine label identical materials, the diameter of described protrusion means 4 maximums is 1mm, respectively over against being right against three through holes 5.
Figure 11 has provided the slow release type remote controlled electronic capsule structural representation of present embodiment.
Embodiment 5:
The primary structure of present embodiment is identical with embodiment 3, difference is: also be plugged with sealing-plug 6 in the through hole 5, sealing-plug 6 constitutes airtight the cooperation with the wall of through hole 5, the frictional force of sealing-plug 6 and through hole 5 is between the 2-3 newton, and diaphragm seal 15, sealing-plug 6 constitute the drug release passage mechanism of slow release type remote controlled electronic capsule with through hole 5.
Figure 12 has provided the slow release type remote controlled electronic capsule structural representation of present embodiment.Diaphragm seal 15, sealing-plug 6 constitute the drug release passage mechanism of slow release type remote controlled electronic capsule with through hole 5, have increased the reliability of sealing.

Claims (4)

1.缓释型遥控电子胶囊，包括胶囊外壳、遥控驱动机构、药物释放通道机构，其特征在于所述的缓释型遥控电子胶囊包括一个固体药物片芯，该药物片芯包含了待释放药物，药物片芯的一端的表面具有至少一个圆柱体形或者圆锥体形的凸起机构，凸起机构为水溶性材料或者与药物片芯相同的材料制作而成，所述凸起机构正对于药物释放通道机构，药物释放通道机构打开后的通道直径大于凸起机构的直径，药物片芯作为一个整体不能通过药物释放通道机构，遥控驱动机构接收到外界发出的遥控信号后，产生一个驱动力，驱动力施加于药物片芯上，药物片芯向具有药物释放通道机构的一端运动，凸起机构在驱动力的作用下打开药物释放通道机构。1. Slow-release remote-controlled electronic capsule, comprising a capsule shell, a remote-controlled drive mechanism, and a drug release channel mechanism, characterized in that the slow-release remote-controlled electronic capsule includes a solid drug core, which contains a drug to be released The surface of one end of the drug tablet core has at least one cylindrical or conical convex mechanism, the convex mechanism is made of water-soluble material or the same material as the drug tablet core, and the convex mechanism is facing the drug release channel Mechanism, after the drug release channel mechanism is opened, the channel diameter is larger than the diameter of the protrusion mechanism, and the drug tablet core as a whole cannot pass through the drug release channel mechanism. After the remote control drive mechanism receives the remote control signal from the outside, it generates a driving force. Applied on the drug tablet core, the drug tablet core moves to one end with the drug release channel mechanism, and the protrusion mechanism opens the drug release channel mechanism under the action of the driving force. 2.根据权利要求1所述的缓释型遥控电子胶囊，其特征在于所述的缓释型遥控电子胶囊的外壳的一端有一个或者多个圆形通孔，圆形通孔的直径在0.5mm-6mm之间，圆形通孔的长度在0.5mm-5mm之间，圆形通孔中塞有密封塞，密封塞与圆形通孔的壁构成密闭配合，密封塞与圆形通孔壁的摩擦力在1-5牛顿之间，密封塞与圆形通孔构成缓释型遥控电子胶囊的药物释放通道机构，药物片芯上具有与圆形通孔数量相等的凸起机构，凸起机构的长度不大于圆形通孔的长度，凸起机构为直径小于圆形通孔的圆柱体、或者圆锥体，药物片芯上的凸起机构正对圆形通孔并且轴线重合，遥控驱动机构接收到外界发出的遥控信号后，产生驱动力，驱动力施加于药物片芯上，药物片芯向圆形通孔端运动，凸起机构插入圆形通孔，并将密封塞推出，从而打开通道机构。2. The slow-release type remote-control electronic capsule according to claim 1, characterized in that one end of the shell of the slow-release type remote-control electronic capsule has one or more circular through holes, and the diameter of the circular through hole is 0.5 Between mm-6mm, the length of the circular through hole is between 0.5mm-5mm, the circular through hole is filled with a sealing plug, the sealing plug and the wall of the circular through hole form an airtight fit, the sealing plug and the circular through hole The friction force of the wall is between 1-5 Newton. The sealing plug and the circular through hole constitute the drug release channel mechanism of the slow-release remote control electronic capsule. The length of the protruding mechanism is not greater than the length of the circular through hole. The protruding mechanism is a cylinder or cone with a diameter smaller than the circular through hole. The protruding mechanism on the drug tablet core is facing the circular through hole and the axis coincides. After the driving mechanism receives the remote control signal from the outside, it generates a driving force, which is applied to the drug tablet core, and the drug tablet core moves toward the end of the circular through hole, and the protruding mechanism is inserted into the circular through hole, and the sealing plug is pushed out. The channel mechanism is thereby opened. 3.根据权利要求1所述的缓释型遥控电子胶囊，其特征在于所述的缓释型遥控电子胶囊的外壳的一端上有一个或者多个圆形通孔，圆形通孔的直径在0.5mm-6mm之间，圆形通孔的长度在0.5mm-5mm之间，缓释型遥控电子胶囊外壳具有圆形通孔一端的内表面固定有厚度小于0.3mm的密封膜，密封膜与圆形通孔构成密闭配合，密封膜与圆形通孔构成缓释型遥控电子胶囊的药物释放通道机构，药物片芯上的凸起机构为直径小于圆形通孔的圆柱体、或者圆锥体，药物片芯上的凸起机构正对圆形通孔并且轴线重合，遥控驱动机构接收到外界发出的遥控信号后，产生一个驱动力，驱动力施加于药物片芯上，药物片芯向圆形通孔端运动，凸起机构插入圆形通孔，刺破密封膜，从而打开通道机构。3. The slow release type remote control electronic capsule according to claim 1, characterized in that one or more circular through holes are arranged on one end of the shell of the slow release type remote control electronic capsule, and the diameter of the circular through hole is between Between 0.5mm-6mm, the length of the circular through hole is between 0.5mm-5mm, the slow-release remote control electronic capsule shell has a sealing film with a thickness of less than 0.3mm fixed on the inner surface of one end of the circular through hole, the sealing film and The circular through hole constitutes a closed fit, the sealing film and the circular through hole constitute the drug release channel mechanism of the slow-release remote control electronic capsule, and the convex mechanism on the drug tablet core is a cylinder or cone whose diameter is smaller than the circular through hole , the protruding mechanism on the drug core is facing the circular through hole and the axis coincides. After receiving the remote control signal from the outside, the remote control drive mechanism generates a driving force, which is applied to the drug core, and the drug core moves toward the circle. The end of the shaped through hole moves, and the protruding mechanism is inserted into the circular through hole, piercing the sealing film, thereby opening the channel mechanism. 4.根据权利要求1所述的缓释型遥控电子胶囊，其特征在于所述的缓释型遥控电子胶囊的外壳的一端上有一个或者多个圆形通孔，圆形通孔的直径在0.5mm-6mm之间，圆形通孔的长度在0.5mm-5mm之间，缓释型遥控电子胶囊外壳具有圆形通孔一端的内表面固定有厚度小于0.3mm的密封膜，密封膜与圆形通孔构成密闭配合，圆形通孔中塞有密封塞，密封塞与圆形通孔的壁构成密闭配合，密封塞与圆形通孔壁的摩擦力在1-5牛顿之间，密封膜、密封塞与圆形通孔一起构成缓释型遥控电子胶囊的药物释放通道机构，药物片芯上的凸起机构为直径小于圆形通孔的圆柱体、或者圆锥体，药物片芯上的凸起机构正对圆形通孔并且轴线重合，遥控驱动机构接收到外界发出的遥控信号后，产生一个驱动力，驱动力施加于药物片芯上，药物片芯向圆形通孔端运动，凸起机构插入圆形通孔，刺破密封膜，并将密封塞推出，从而打开通道机构。4. The slow-release type remote control electronic capsule according to claim 1, characterized in that one or more circular through holes are arranged on one end of the shell of the slow release type remote control electronic capsule, and the diameter of the circular through hole is between Between 0.5mm-6mm, the length of the circular through hole is between 0.5mm-5mm, the slow-release remote control electronic capsule shell has a sealing film with a thickness of less than 0.3mm fixed on the inner surface of one end of the circular through hole, the sealing film and The circular through hole constitutes a closed fit, the circular through hole is plugged with a sealing plug, the sealing plug forms a closed fit with the wall of the circular through hole, and the friction force between the sealing plug and the wall of the circular through hole is between 1-5 Newton, The sealing film, the sealing plug and the circular through hole together constitute the drug release channel mechanism of the sustained-release remote control electronic capsule. The convex mechanism on the drug tablet core is a cylinder or cone whose diameter is smaller than the circular through hole. The drug tablet core The protruding mechanism on the top is facing the circular through hole and the axis coincides. After receiving the remote control signal from the outside, the remote control drive mechanism generates a driving force, which is applied to the drug core, and the drug core moves toward the end of the circular through hole. Movement, the protruding mechanism is inserted into the circular through hole, pierces the sealing membrane, and pushes the sealing plug out, thereby opening the channel mechanism.
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