CN100450520C - Medicine for treating chronic glomerular nephritis and its producing method - Google Patents
Medicine for treating chronic glomerular nephritis and its producing method Download PDFInfo
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- CN100450520C CN100450520C CNB2006100455924A CN200610045592A CN100450520C CN 100450520 C CN100450520 C CN 100450520C CN B2006100455924 A CNB2006100455924 A CN B2006100455924A CN 200610045592 A CN200610045592 A CN 200610045592A CN 100450520 C CN100450520 C CN 100450520C
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- radix
- chronic glomerulonephritis
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- hirudo
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- 239000003814 drug Substances 0.000 title claims abstract description 38
- 229940079593 drug Drugs 0.000 title claims description 16
- 238000000034 method Methods 0.000 title description 5
- 206010018364 Glomerulonephritis Diseases 0.000 title 1
- 230000001684 chronic effect Effects 0.000 title 1
- 206010018367 Glomerulonephritis chronic Diseases 0.000 claims abstract description 15
- 239000000843 powder Substances 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 11
- 244000268590 Euryale ferox Species 0.000 claims abstract description 10
- 235000006487 Euryale ferox Nutrition 0.000 claims abstract description 7
- 239000000203 mixture Substances 0.000 claims abstract description 5
- 238000001035 drying Methods 0.000 claims abstract description 4
- 238000011282 treatment Methods 0.000 claims description 18
- 210000000582 semen Anatomy 0.000 claims description 14
- 241000237903 Hirudo Species 0.000 claims description 9
- 239000009636 Huang Qi Substances 0.000 claims description 9
- 238000002360 preparation method Methods 0.000 claims description 5
- 239000000706 filtrate Substances 0.000 claims description 3
- 239000006187 pill Substances 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 5
- 239000000463 material Substances 0.000 abstract 3
- 240000006766 Cornus mas Species 0.000 abstract 1
- 241000034009 Lycopus Species 0.000 abstract 1
- 241000405414 Rehmannia Species 0.000 abstract 1
- 229940107666 astragalus root Drugs 0.000 abstract 1
- 230000006837 decompression Effects 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 238000007873 sieving Methods 0.000 abstract 1
- 206010030113 Oedema Diseases 0.000 description 13
- 210000000952 spleen Anatomy 0.000 description 12
- 230000007812 deficiency Effects 0.000 description 9
- 210000003734 kidney Anatomy 0.000 description 7
- 208000011580 syndromic disease Diseases 0.000 description 7
- 208000004880 Polyuria Diseases 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 230000035619 diuresis Effects 0.000 description 4
- 241000721047 Danaus plexippus Species 0.000 description 3
- 230000001939 inductive effect Effects 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 230000002110 toxicologic effect Effects 0.000 description 3
- 231100000027 toxicology Toxicity 0.000 description 3
- 206010003549 asthenia Diseases 0.000 description 2
- 230000008506 pathogenesis Effects 0.000 description 2
- 230000003285 pharmacodynamic effect Effects 0.000 description 2
- 206010010356 Congenital anomaly Diseases 0.000 description 1
- 208000002720 Malnutrition Diseases 0.000 description 1
- 206010027336 Menstruation delayed Diseases 0.000 description 1
- 208000001647 Renal Insufficiency Diseases 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 230000001882 diuretic effect Effects 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 206010016256 fatigue Diseases 0.000 description 1
- 238000002309 gasification Methods 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 201000006370 kidney failure Diseases 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000001071 malnutrition Effects 0.000 description 1
- 235000000824 malnutrition Nutrition 0.000 description 1
- 230000004630 mental health Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 208000015380 nutritional deficiency disease Diseases 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
The Chinese medicine for treating chronic glomerulonephritis is prepared with astragalus root, rehmannia root, dogwood, Gordon euryale seed lycopus herb and other seven kinds of Chinese medicinal materials. It is prepared through grinding its six kinds of Chinese medicinal materials into fine powder; decocting the other six kinds of Chinese medicinal materials, filtering, decompression concentrating, vacuum low temperature drying, crushing and sieving to obtain the other kind of powder; mixing two kinds of powder; and preparing the mixture into water bolus. The present invention has the features of obvious curative effect, convenient taking, high safety, etc.
Description
Technical field
The present invention relates to a kind of with medicine (nephritislin) and preparation method thereof the Chinese medicine composition, treatment chronic glomerulonephritis (spleen deficiency of kidney-QI edema syndrome).
Background technology
Chronic glomerulonephritis is common clinical, frequently-occurring disease, belongs to " edema " category of motherland's medical science, the concealment of the most onset of this disease, slowly, the course of disease is long; Particularly should disease late period, the state of an illness further develops, immunologic function degression, the body malnutrition clinically deficient performances such as edema, anemia, fatigue and weakness occur, very the person forms renal failure, has a strong impact on patient's physical and mental health.Though the medicine of some treatments is arranged at present, certain therapeutic effect is also arranged, therapeutic effect is not obvious, and the specific drug with remarkable result does not also have at present.
Summary of the invention
The objective of the invention is to develop better motherland's medicine and pharmacology, exploitation traditional Chinese medicines resource, utilize natural plants---medicine, a kind of medicine (nephritislin) for the treatment of chronic glomerulonephritis is provided, it is remarkable, esy to use, safe and reliable that it has clinical efficacy; The present invention also provides a kind of method of producing this medicine.
For achieving the above object, the technical scheme that the present invention takes is: be the basis according to motherland's theory of medicine, draw the modern study elite, in conjunction with clinical experience for many years, at the pathogenesis of chronic glomerulonephritis (spleen deficiency of kidney-QI edema syndrome) " asthenia of both the spleen and kidney, deficiency of vital energy water is general ", according to monarch, the minister of Chinese medicine, help, make the combination principle dialectical prescription, throw the treatment principle of " kidney and spleen invigorating, QI invigorating consolidate, inducing diuresis to remove edema ", and reach therapeutic purposes.
Medicine of the present invention is formed, and by its weight ratio is: the Radix Astragali 4000～4200g, Herba Lycopi 2400～2500g, Semen Plantaginis 2400～2500g, Rhizoma Dioscoreae 2400～2500g, Rhizoma Alismatis 2400～2500g, Semen Euryales 2400～2500g, Radix Rehmanniae 2400～2500g, Fructus Corni 2400～2500g, Periostracum Cicadae 1600～1700g, Radix Cynanchi Paniculati 2400～2500g, Herba Hedyotidis Diffusae 2400～2500g, Hirudo 800～850g.
The optimization of medicine of the present invention is formed, and by its weight ratio is: the Radix Astragali 4050～4100g, Herba Lycopi 2430～2450g, Semen Plantaginis 2430～2450g, Rhizoma Dioscoreae 2430～2450g, Rhizoma Alismatis 2430～2450g, Semen Euryales 2430～2450g, Radix Rehmanniae 2430～2450g, Fructus Corni 2430～2450g, Periostracum Cicadae 1620～1640g, Radix Cynanchi Paniculati 2430～2450g, Herba Hedyotidis Diffusae 2430～2450g, Hirudo 810～830g.
Preparation method of the present invention: each forms medicine by its weight ratio outfit, and the Radix Astragali, Herba Lycopi, Semen Plantaginis, Rhizoma Dioscoreae, Rhizoma Alismatis, gorgon euryale seed powder are broken into fine powder, crosses 100～120 mesh sieves, and is standby.Get Radix Rehmanniae, Fructus Corni, Periostracum Cicadae, Radix Cynanchi Paniculati, Herba Hedyotidis Diffusae, Hirudo again, decocting boils 2 times; First decocts 3h, filters; Second decocts 1.5h, filters; Merge filtrate twice, become the thick paste shape at concentrating under reduced pressure below 80 ℃; With behind the thick paste vacuum dehydrating at lower temperature, pulverize again, cross 100 mesh sieves, standby.Get again behind above two kinds of medicated powder mix homogeneously with cold boiled water is general and be water pill, be packaged into bag after the drying.Can be for using.
In the medicine of the present invention: the Radix Astragali, Radix Rehmanniae, Fructus Corni, Semen Euryales are monarch drug, and this four Chinese medicine can be mended the congenital foundation, are again the benefit source of the day after tomorrow; Play altogether that kidney and spleen invigorating, QI invigorating consolidate, the effect of inducing diuresis to remove edema.Herba Lycopi, Semen Plantaginis, Rhizoma Alismatis, Rhizoma Dioscoreae are ministerial drug, have promoting diuresis to eliminate damp pathogen, add the gasification of kidney tonifying, promote the metabolism of water liquid, assist monarch drug and the purpose of Dary water detumescence.Periostracum Cicadae, Radix Cynanchi Paniculati, Herba Hedyotidis Diffusae, Hirudo are adjuvant, are healthy and strong in the kidney invigorating, in the enhancing human body immunity, and the also double short diuretic of invigorating blood circulation is beneficial to eliminate the effect of edema.All medicines share, and kidney and spleen invigorating, QI invigorating consolidate, the effect of inducing diuresis to remove edema and play, and at asthenia of both the spleen and kidney, the general pathogenesis of deficiency of vital energy water is the method for treatment of shooting the arrow at the target.Therefore, the present invention has characteristics such as clinical efficacy is remarkable, esy to use, safe and reliable.
The specific embodiment
The medicine of the embodiment of the invention is formed, and by its weight ratio is: the Radix Astragali 4050～4100g, Herba Lycopi 2430～2450g, Semen Plantaginis 2430～2450g, Rhizoma Dioscoreae 2430～2450g, Rhizoma Alismatis 2430～2450g, Semen Euryales 2430～2450g, Radix Rehmanniae 2430～2450g, Fructus Corni 2430～2450g, Periostracum Cicadae 1620～1640g, Radix Cynanchi Paniculati 2430～2450g, Herba Hedyotidis Diffusae 2430～2450g, Hirudo 810～830g.
The preparation method of present embodiment: earlier various medicines are equipped with by above-mentioned weight ratio.Again the Radix Astragali, Herba Lycopi, Semen Plantaginis, Rhizoma Dioscoreae, Rhizoma Alismatis, gorgon euryale seed powder are broken into fine powder, cross 100～120 mesh sieves, standby.Get Radix Rehmanniae, Fructus Corni, Periostracum Cicadae, Radix Cynanchi Paniculati, Herba Hedyotidis Diffusae, Hirudo again, decocting boils 2 times; First decocts 3h, filters; Second decocts 1.5h, filters; Merge filtrate twice, become the thick paste shape at concentrating under reduced pressure below 80 ℃; With behind the thick paste vacuum dehydrating at lower temperature, pulverize again, cross 100 mesh sieves, standby.Get again behind above two kinds of medicated powder mix homogeneously with cold boiled water is general and be water pill, be packaged into every bag of 9g (being about crude drug in whole 30g) after the drying, for use.
During use, one bag of the every clothes of being grown up, every day 3 times.
Medicine of the present invention is observed through clinical 120 patients, and wherein 90 people are organized in treatment, matched group 30 people.Adopt the treatment group of Drug therapy of the present invention, 67 people of produce effects are arranged, effective 18 people, the total effective rate of treatment group is 94.44%, wherein obvious effective rate is up to 75.00%.Though and the matched group total effective rate is 93.33%, obvious effective rate has only 18.00% (seeing the investigative technique report of nephritislin treatment chronic glomerulonephritis spleen deficiency of kidney-QI edema syndrome for details).This shows that medicine of the present invention is the specific drug of treatment chronic glomerulonephritis (spleen deficiency of kidney-QI edema syndrome).
Medicine of the present invention proves through toxicological experiment, oral safety of medicine of the present invention reliable (seeing nephritislin treatment chronic glomerulonephritis spleen deficiency of kidney-QI edema syndrome pharmacodynamics, toxicologic research report for details).
Therefore the present invention has clinical efficacy height, characteristics such as esy to use, safe and reliable.For the treatment chronic glomerulonephritis provides a kind of specific drug.
Adnexa: 1, " the investigative technique report of nephritislin treatment chronic glomerulonephritis spleen deficiency of kidney-QI edema syndrome "
2, Shandong Province's Experimental Animal Center: " nephritislin treatment chronic glomerulonephritis spleen deficiency of kidney-QI edema syndrome pharmacodynamics, toxicologic research report "
Claims (3)
1, a kind of medicine of the treatment chronic glomerulonephritis of being made up of Chinese medicine is characterized in that the crude drug weight ratio is: the Radix Astragali 4000～4200g, Herba Lycopi 2400～2500g, Semen Plantaginis 2400～2500g, Rhizoma Dioscoreae 2400～2500g, Rhizoma Alismatis 2400～2500g, Semen Euryales 2400～2500g, Radix Rehmanniae 2400～2500g, Fructus Corni 2400～2500g, Periostracum Cicadae 1600～1700g, Radix Cynanchi Paniculati 2400～2500g, Herba Hedyotidis Diffusae 2400～2500g, Hirudo 800～850g.
2, the medicine of treatment chronic glomerulonephritis according to claim 1 is characterized in that the crude drug weight ratio is: the Radix Astragali 4050～4100g, Herba Lycopi 2430～2450g, Semen Plantaginis 2430～2450g, Rhizoma Dioscoreae 2430～2450g, Rhizoma Alismatis 2430～2450g, Semen Euryales 2430～2450g, Radix Rehmanniae 2430～2450g, Fructus Corni 2430～2450g, Periostracum Cicadae 1620～1640g, Radix Cynanchi Paniculati 2430～2450g, Herba Hedyotidis Diffusae 2430～2450g, Hirudo 810～830g.
3, the preparation method of the described treatment chronic glomerulonephritis of a kind of claim 1 medicine is characterized in that: each crude drug is equipped with by its weight ratio, and the Radix Astragali, Herba Lycopi, Semen Plantaginis, Rhizoma Dioscoreae, Rhizoma Alismatis, gorgon euryale seed powder are broken into fine powder, crosses 100～120 mesh sieves, and is standby; Get Radix Rehmanniae, Fructus Corni, Periostracum Cicadae, Radix Cynanchi Paniculati, Herba Hedyotidis Diffusae, Hirudo again, decocting boils 2 times, and first decocts 3h, filters; Second decocts 1.5h, filters; Merge filtrate twice, become the thick paste shape at concentrating under reduced pressure below 80 ℃; With behind the thick paste vacuum dehydrating at lower temperature, pulverize again, cross 100 mesh sieves, standby; Get again behind above two kinds of medicated powder mix homogeneously with cold boiled water is general and be water pill, be packaged into bag after the drying.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100455924A CN100450520C (en) | 2006-07-19 | 2006-07-19 | Medicine for treating chronic glomerular nephritis and its producing method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100455924A CN100450520C (en) | 2006-07-19 | 2006-07-19 | Medicine for treating chronic glomerular nephritis and its producing method |
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| Publication Number | Publication Date |
|---|---|
| CN1899482A CN1899482A (en) | 2007-01-24 |
| CN100450520C true CN100450520C (en) | 2009-01-14 |
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| CNB2006100455924A Expired - Fee Related CN100450520C (en) | 2006-07-19 | 2006-07-19 | Medicine for treating chronic glomerular nephritis and its producing method |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103127420B (en) * | 2013-02-26 | 2014-05-14 | 山东省立医院 | Traditional Chinese medicinal composition for treating chronic glomerulonephritis |
| CN113713039A (en) * | 2016-04-21 | 2021-11-30 | 陕西中医药大学附属医院 | Traditional Chinese medicine composition for treating membranous nephropathy and application thereof |
| CN106334028A (en) * | 2016-11-01 | 2017-01-18 | 涿州东乐制药有限公司 | Traditional Chinese medicine composition for treating diabetic nephropathy |
| CN108524640A (en) * | 2018-07-13 | 2018-09-14 | 曹国文 | A kind of Chinese medicine composition and preparation method thereof for treating nephrosis |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1268355A (en) * | 2000-01-08 | 2000-10-04 | 陈柏林 | Yichanmanshenkang medicine for curing nephroses |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1268355A (en) * | 2000-01-08 | 2000-10-04 | 陈柏林 | Yichanmanshenkang medicine for curing nephroses |
Non-Patent Citations (2)
| Title |
|---|
| 慢性肾小球肾炎的中医药治疗近况. 曹建宏等.中国实验方剂学杂志，第2卷第3期. 1996 |
| 慢性肾小球肾炎的中医药治疗近况. 曹建宏等.中国实验方剂学杂志，第2卷第3期. 1996 * |
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| CN1899482A (en) | 2007-01-24 |
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