CN100432103C

CN100432103C - 有效治疗肿瘤和其它需要除去或破坏细胞的疾病的肽

Info

Publication number: CN100432103C
Application number: CNB028183320A
Authority: CN
Inventors: P·A·艾弗白克; J·杰梅尔
Original assignee: Nymox Corp Canada
Current assignee: Nymox Corp Canada
Priority date: 2001-07-19
Filing date: 2002-07-19
Publication date: 2008-11-12
Anticipated expiration: 2022-07-19
Also published as: CN1714101A

Abstract

本发明涉及用于治疗需要除去或破坏患者的有害细胞或不想要的组织的疾病的肽，组合物和方法，该方法采用含有衍生自神经丝状蛋白至少一种氨基酸序列和其它相关分子的蛋白质，和衍生自该蛋白质氨基酸序列的肽进行治疗。

Description

有效治疗肿瘤和其它需要除去或破坏细胞的疾病的肽

本申请要求2001年7月19日提交的题为“有效治疗肿瘤和其它需要除去或破坏细胞的疾病的蛋白质和肽”的临时申请序列号60/306,161的优先权，2001年7月19日提交的题为“有效治疗肿瘤和其它需要除去或破坏细胞的疾病的肽”的临时专利申请序列号60/306,150的优先权，以及2001年11月16日提交的题为“有效治疗肿瘤和其它需要除去或破坏细胞的疾病的肽”的临时专利申请序列号60/331,477的优先权，在此将它们全文并入以供参考。

发明领域

本发明涉及用含有对应于、相似于或同源于神经丝状蛋白的部分氨基酸序列的氨基酸序列的蛋白质和肽化合物治疗疾病的方法，这类疾病需要除去或破坏细胞成分，如良性或恶性肿瘤。该方法包括但不限于肌肉内、口服、静脉内、鞘内、肿瘤内、鼻内、局部、透皮等给所述化合物，或单独或偶联于载体的所述化合物。

发明背景

许多医学治疗和过程包括除去或破坏有害或不想要的组织。这种重要治疗的例子包括手术除去癌性生长物、通过化疗破坏转移性肿瘤和减少腺体(如前列腺)增生。其它例子包括除去不想要的面部毛发、疣、皮下组织、淋巴组织或脂肪组织。

需要有效的制剂来破坏从而便于除去有害或不想要的细胞和组织或抑制其进一步生长，主要是局部作用而全身毒性最小或没有。神经丝状蛋白及其相关分子是2002年3月8日提交的题为“用神经丝状蛋白治疗肿瘤和相关疾病的方法”的待审批美国专利申请序列号10/092,934所描述的这类制剂之一，其公布的内容全部纳入本文供参考。含有与神经丝状蛋白部分氨基酸序列相对应的氨基酸序列的肽，AD7c-NTP也是这类试剂。这些肽可参见2002年5月24日提交的题为“有效治疗肿瘤和其它需要除去或破坏细胞的疾病的肽”的待审批美国专利申请序列号10/153,334中的描述，其公布的内容全部纳入本文供参考。

癌是细胞内部调节机制发生的异常，导致不受控制的细胞生长和繁殖。正常细胞构成组织，当这些细胞失去作为特定、受控制和协同单元的能力(去分化)时，这种缺陷会导致细胞群发生混乱。当它发生时，即形成肿瘤。

组织的良性过度生长是异常情况，此时需要从机体中除去细胞。良性肿瘤是不会全身转移但能引起疾病症状的细胞增殖。如果这种肿瘤位于器官如脑中难以到达的区域，它们可能是致命的。良性肿瘤存在于许多器官中，包括肺、脑、皮肤、垂体、甲状腺、肾上腺皮质和肾上腺髓质、卵巢、子宫、睾丸、结缔组织、肌肉、肠、耳、鼻、喉、扁桃腺、口、肝脏、胆囊、胰、前列腺、心和其它器官。

在癌症治疗中手术通常是第一步。手术的目的不同。有时用手术的除尽可能多的明显肿瘤，或至少使它“除块”(节除主要的肿瘤块从而减少对其它方法治疗的需要)。取决于癌种类和位置，手术也可为病人提供一些症状缓解。例如，如果手术切除了大部分扩增的脑肿瘤，颅内压将减少，使病人的症状改善。

不是所有的肿瘤都可以手术切除。一些肿瘤可能位于使它们不能完全被切除的身体部位。这些肿瘤例子是脑干中的肿瘤(控制呼吸的脑部分)或生长在主要血管中和周围的肿瘤。在这些情况中，由于肿瘤切除相关的高风险，手术的实施受到限制。

在一些情况中，由于不需要，不能用手术切除肿瘤块。一个例子是何杰金淋巴瘤，这是一种对化疗和放射治疗相联合有良好反应的淋巴结癌症。在何杰金淋巴瘤中，很少需要手术来达到治愈，而手术几乎都是用于确定诊断。

化疗是癌治疗的一种常用形式，包括使用能特异性攻击全身中快速分裂细胞(如肿瘤中所见的细胞)的药物(通常通过口服或注射给予)。这使化疗可用于治疗转移癌以及有很高机会通过血液和淋巴系统扩散但尚未明显超过原发性肿瘤部位的肿瘤。化疗也可用于提高局部肿瘤对手术和放疗的反应。例如对于一些头部和颈部的癌症。

不幸的是，人体中正常快速分裂的其它细胞(如胃的内皮层和毛发)也会受到化疗影响。由于这个原因，许多化疗剂会导致不良副作用如恶心、呕吐、贫血、脱发或其它症状。这些副作用是暂时性的，目前的药物可帮助减轻许多这些副作用。随着我们的知识持续增长，学者们设计了更加新的化疗剂，它们不仅能更好地杀死癌细胞且对病人的副作用更小。

化疗药物可以多种方式给予病人。一些是药丸，一些通过静脉内或其它部位注射给药。就可注射的化疗药物而言，病人须到医生诊所或医院接受治疗。其它化疗剂需要一天24小时连续输入血流中。对于这些类型的化疗药物，可进行小手术给病人植入小泵。用泵慢慢给药。在许多情况中，须在病人静脉中安置永久性输液管口以消除反复针刺的需要。

放疗是另一种抗癌的常用武器。放射线通过破坏肿瘤细胞内的DNA来杀死癌。放疗可用不同方式传送。最普通的方法包括以高度精确方式使放射线束指向病人，集中照射在肿瘤上。为此，病人须躺在台上光束围绕他/她周围移动。此可程持续几分钟，但可每天进行，连续数周(取决于肿瘤类型)以达到具体的总处方放射量。

有时采用称为近程治疗的另一种放射方法，包括采用放射性小丸(“辐射盒”)或电线，将它们植入身体的肿瘤区域中。植入物可以是暂时或永久性的。就永久性植入而言，辐射盒中的射线在几天或几周中“衰变”从而病人不会有放射性。就暂时性植入而言，总放射剂量通常须在数天中输入，病人在此时间中必须住院。对于这两种近程治疗，一般须将放射线准确关至肿瘤区域以获得对癌症的局部控制(此与全身治疗相反，如化疗)。

一些高度选择的病人可求助于骨髓移植。通常进行此种治疗是因为病人患有显著的攻击性癌或因为他们经常规疗法治疗后癌症复发。骨髓移植是一种复杂的过程。有许多种类且它们引起副作用和治愈的可能性不同。大多数移植须在特殊的医疗中心进行，在许多情况中采用移植认为是研究性的。

有一些其它治疗方法，尽管大部分仍在临床考核中探索，未成为标准治疗方法。例子包括免疫治疗、单克隆抗体、抗血管生成因子和基因治疗。

免疫治疗：设计了多种技术以促进病人自身免疫系统抵抗癌症，这与放射治疗或化疗完全不同。通常为达到此目的，学者们用特制疫苗给病人注射。单克隆抗体：设计用于攻击癌细胞(不攻击正常细胞)的抗体，利用癌和非癌细胞之间抗原性或/或其它特征的差异。抗体可单独给予病人，或与各种细胞毒化合物偶联或采用放射性形式，使抗体优先靶向癌性细胞，从而将毒性剂或放射剂递送给需要的细胞。

抗血管生成因子：由于癌细胞迅速分裂和肿瘤生长，它们可能很快长得比其血液供应还快。为补偿这点，一些肿瘤可分泌协助诱导其周围血管生长的物质，从而向癌细胞提供血管输送的营养物。已设计了实验性疗法以阻止血管长入肿瘤。

基因疗法：癌是一系列突变的产物，最终导致癌细胞产生和其过度增殖。治疗癌可将能控制或停止癌增殖的基因引入癌细胞、开启细胞的程序性细胞(死亡)机制破坏癌细胞、提高细胞的免疫识别、或表达能转变成毒性代谢物的前体药物或抑制肿瘤生长的细胞因子。

良性肿瘤和畸形也可通过多种方法治疗，包括手术、放射治疗、药物治疗、热和电烧灼、冷冻疗法等。尽管良性肿瘤不转移，它们可长大且可复发。手术根除良性肿瘤通常有困难和手术副作用，而一些良性肿瘤须要反复进行手术，如垂体腺瘤、脑膜瘤、前列腺增生等。

还有其它一些疾患包含不想要的细胞成分，需要选择性去除这些细胞。例如心脏病和中风一般由动脉粥样硬化所引起，而动脉粥样硬化是纤维脂肪和平滑肌成分的增殖性损伤而致使血管壁扭曲、血管腔狭窄、血流收缩、易发病灶性血栓并最终导致阻塞和梗塞。治疗动脉粥样硬化的各种方法包括：旁路移植；人工移植；采用血管再通、刮除、放射、激光或其它去除阻塞的血管成形术；通过脂质减少抑制动脉粥样硬化的药物疗法；抗血凝治疗；和饮食、锻炼及生活方式的全身疗法。仍需要一种除去动脉粥样硬化性损伤而无风险和副作用的方法。

其它需要选择性去除不想要的细胞丰分例子，包括病毒诱导的生长物如疣。另一个例子是炎症情况中所见的肥大炎性块和肥大疤痕或瘢痕疙瘩。其它例子见于化妆美容时例如除去不想要的毛发如面部汗毛，或为美容目的须除去面部皮肤和结缔组织或四肢皮肤和结缔组织中的皱缩的不需要的组织区域。

其它例子是此领域一般技术人员知道的。在所有或大部分这些例子中，都需要能除去或破坏不想要的细胞成分进行治疗，而无常规疗法的风险和副作用，和需要更精确除去不想要的细胞成分的方法。

神经丝状蛋白(NTP)是最近才鉴定的一个脑蛋白质家族。此家族成员之一AD7c-NTP是41kD功能与神经芽生相关的膜结合磷蛋白(de la Monte等，J.Clin.Invest.，100：3093-3104(1997)；de la Monte等，Alz.Rep.，2：327-332(1999)；de la Monte SM和Wands JR，Journal of Alzheimer’s Disease，3：345-353(2001))。已鉴定和报道了编码AD7c-NTP的基因和AD7c-NTP的预测蛋白质序列(de laMonte等，J.Clin.Invest.，100：3093-3104(1997))。除了41kD种类外，其它种类的神经丝状蛋白(约26kD、约21kD、约17kD和约15kD)也已鉴定并与神经外胚层瘤、星形细胞瘤和成胶质细胞瘤以及缺氧、局部缺血或脑梗塞引起的损伤相关联(Xu等，Cancer Research，53：3823-3829(1993)；de la Monte等，J.Neuropathol.Exp.Neurol.，55(10)：1038-50(1996)，de la Monte等，J.Neurol.Sci.，138(1-2)：26-35(1996)；de la Monte等，J.Neurol.Sci.，135(2)：118-25(1996)；de la Monte等，J.Clin.Invest.，100：3093-3104(1997)；de la Monte等，Alz.Rep.，2：327-332(1999))。

对神经丝状蛋白的种类已有描述和权利要求，见美国专利号5,948,634；5,948,888和5,830,670中所有关于“阿尔茨海默氏病的神经丝状蛋白基因表达和检测”和美国专利号6,071,705关于“检测神经疾病或功能不良的方法”。这些专利所披露内容特别地全部纳入本文供参考。如其中所述，NTP在细胞死亡期间上调和产生。因此，报道认为死亡和垂死的神经细胞系过度产生NTP而致，因而它的存在表明神经细胞死亡和阿尔茨海默氏病(AD)发作。

已将其它种类的神经丝状蛋白鉴定为AD7c-NTP基因的其它产物(如描述于NCBI Entrez-蛋白质数据库登录号#XP_032307 PID g15928971的一种112个氨基酸的蛋白质)或类似于神经丝状蛋白(如描述于NCBI Entrez-蛋白质数据库登录号#AAH14951 PID g15928971的一种106个氨基酸的蛋白质，描述于NCBI Entrez-蛋白质数据库登录号#XP_039102 PID g18599339的另一种106个氨基酸的蛋白质和描述于NCBI Entrez-蛋白质数据库登录号#AAH02534 PID g12803421的一种61个氨基酸的蛋白质)。

与AD和NTP相关的神经丝状蛋白在AD的细胞死亡中上调。与对照相比AD7c-NTP mRNA在AD大脑中上调；AD中大脑和CSF中的AD7c-NTP蛋白水平高于对照；AD7c-NTP的免疫反应性发现于AD和唐氏综合症大脑中的老年斑、神经纤维缠结(NFT)、变性神经元、神经毡丝(neuropil thread)和营养不良性神经芽生中(Ozturk等，Proc.Natl.Acad.Sci.USA，86：419-423(1989)；de la Monte等，J.Clin.Invest.，86(3)：1004-13(1990)；de la Monte等，J.Neurol.Sci.，113(2)：152-64(1992)；de la Monte等，Ann.Neurol.，32(6)：733-42(1992)；de la Monte等，J.Neuropathol.Exp.Neurol.，55(10)：1038-50(1996)，de la Monte等，J.Neurol.Sci.，138(1-2)：26-35(1996)；de la Monte等，J.Neurol.Sci.，135(2)：118-25(1996)；de la Monte等，J.Clin.Invest.，100：3093-3104(1997)；de la Monte等，Alz.Rep.，2：327-332(1999))。NTP定位于细胞内、神经毡内的精细加工中，或AD和唐氏综合症大脑中的细胞外。de la Monte等，Ann.Neurol.，32(6)：733-42(1992)。

在AD病人的CSF和尿中都发现AD7c-NTP蛋白水平升高(de la Monte和Wands，Front Biosci 7：989-96(2002)；de la Monte和Wands，Journal of Alzheimer’sDisease，3：345-353(2001)；Munzar等，Alzheimer’s Reports 4：61-65(2001)；Kahle等，Neurology 54：1498-1504(2000)；Munzar等，Alzheimer’s Reports 3：155-159(2000)；de la Monte等，Alzheimer’s Reports 2：327-332(1999)；和de la Monte等，J Clin Invest 100：3093-3104(1997)。

过度表达NTP也与阿尔茨海默氏病中的细胞死亡过程相联系(de la Monte和Wands，J.Neuropathol Exp.Neurol.，60：195-207(2001)；de la Monte和Wands，CellMol Life Sci 58：844-49(2001)。也在唐氏综合症大脑组织中鉴定到AD7c-NTP(Wands等，国际专利出版号WO 90/06993；de la Monte等，J Neurol Sci 135：118-25(1996)；de la Monte等，Alz.Rep.，2：327-332(1999))。有一些证据表明过度表达NTP也可能与正常张力青光眼相关联(Golubnitschaja-Labudova等，Curr Eye Res21：867-76(2000))。

已证明NTP是在体外神经胶质瘤和成神经细胞瘤的细胞培养物，体内正常啮齿动物肌肉组织、皮下结缔组织和真皮中，以及多种不同人和非人来源的肿瘤(包括乳腺癌、皮肤癌和乳头状瘤、结肠癌、脑胶质瘤和啮齿动物模型中的其它肿瘤)中，能导死细胞死亡的一种有效制剂。参见2002年3月8日提交的待审批美国专利申请序列号10/092,934；题为“用神经丝状蛋白治疗肿瘤和相关疾病的方法”。

此描述中包括上述相关领域的描述、任何和所有本文所述公开的文献，包括任何和所有的美国专利全部纳入本文供参考。上述相关领域的描述不意味着以任何方式承认包括待审批美国专利申请的任何本文所述文献是本发明的现有技术。

* * * *

此领域仍需要新的、毒性较弱的治疗不需要的细胞成分的方法。本发明可满足这些需求。

发明概述

本发明一部分包括本发明者发现AD7c-NTP中所含的肽序列，及其变体或同系物，包括其人和其它哺乳动物等生物的其它蛋白质中发现的肽序列是破坏或除去有害细胞或不想要细胞的有效制剂，。一旦发现了此种肽序列，此领域的一般技术人员就可通过利用广泛存在的公众或商业蛋白质数据库如国家生物技术信息中心的蛋白质数据库(National Center Biotechnology Information′s Protein database)和检索程序如

(局部序列比对基本检索工具)找到这些蛋白质。参见Altschul，Stephen F.，Thomas L.Madden，Alejandro A.

Jinghui Zhang，ZhengZhang，Webb Miller和David J.Lipman(1997)，“缺口BLAST和PSI-BLAST：新一代蛋白质数据库检索程序(Gapped BLAST and PSI-BLAST：a new generation of proteindatabase search programs)”，Nucleic Acids Res.25：3389-3402。

此领域的一般技术人员然后可以用这里描述的测定方法来筛选这些蛋白质，以确定它们作为破坏或除去不需要的或有害细胞的制剂的效力。发现一种或多种这类有效制剂后，此领域的一般技术人员然后可以确定那些制剂中，包含与这里所述或2002年5月24日提交的题为“有效治疗肿瘤和其它需要除去或破坏细胞的疾病的肽”的待审批美国专利申请序列号10/153,334所述的AD7c-NTP肽序列同源或类似的序列，这些制剂可用此领域技术人员已知的方法合成，并测试合成的制剂作为破坏或除去不需要或有害细胞的制剂的效力。此外，此领域的一般技术人员还可所发现的此类蛋白质的氨基酸序列，来确定与本文所述以及2002年5月24日提交的题为“有效治疗肿瘤和其它需要除去或破坏细胞的疾病的肽”的美国专利申请序列号10/153,334所述的AD7c-NTP肽序列不类似或不同源，和同源或类似的其它肽序列。然后可测试这些新合成的序列作为破坏或除去不需要的或有害细胞的制剂的效力。

本发明涉及治疗不需要的细胞增殖的肽、组合物和方法，如良性或恶性肿瘤、腺体(如前列腺)增生、不需要的面部汗毛、疣和不需要的脂肪组织。这种方法包括将治疗有效量的相关蛋白、已知是能导致细胞死亡的有效制剂的相关肽或NTP肽，给予需要的哺乳动物，。“相关蛋白”、“相关肽”和“NTP肽”的定义如下。

本发明的肽具有至少一段与神经丝状蛋白的部分氨基酸序列相对应的氨基酸序列。本发明的组合物包括这种肽和药学上可接受的载体。本发明的肽或蛋白质(“细胞死亡肽”)可单独或者与载体或抗体偶联后施用。施用此细胞死亡肽可通过肌肉内、口服、静脉内、腹膜内、脑内(实质内)、脑室内、肿瘤内、病灶内、皮内、鞘内、鼻内、眼内、动脉内、局部、透皮、通过气雾剂、灌输、推注、植入装置、缓释系统等，或单独或运载体偶联。另外，此细胞死亡肽可通过给予表达此肽的基因来体内表达、通过给予能诱导导入此基因的细胞、细菌或病毒体内表达此肽的疫苗，或导致基因修饰等来产生此肽。

此外，此细胞死亡肽可结合其它疗法用于来治疗良性或恶性肿瘤和其它不想要的或有害的细胞生长。以上一般描述和下列详细描述是示范性和说明性的，将为本发明的权利要求提供进一步说明。从本发明的详细描述中，本领域技术人员不难了解本发明的其它目标、优点和新特征。

附图简述

图1：显示AD7c-NTP基因的完整氨基酸序列和核酸序列以及该基因的AD7c-NTP蛋白产物(获自美国专利号5,830,670、5,948,634和5,948,888的序列120和121；de la Monte等，J.Clin.Invest.，100：3093-3104(1997)；NCBI Entrez-蛋白质数据库登录号#AAC08737；PID g3002527)[SEQ ID NO.1]。

图2：显示122个氨基酸的神经丝状蛋白的完整氨基酸序列(获自美国专利号5,830,670、5,948,634和5,948,888的序列40；NCBI Entrez-蛋白质数据库登录号#AAE25447 PID g10048540)[SEQ ID NO.2](“NTP-122”)。

图3：显示112个氨基酸的神经丝状蛋白的完整氨基酸序列(NCBI Entrez-蛋白质数据库登录号#XP_032307 PID g15928971)[SEQ ID NO.3](“NTP-112”)。

图4：显示106个氨基酸的神经丝状蛋白样蛋白质的完整氨基酸序列(NCBIEntrez-蛋白质数据库登录号#AAH14951 PID g15928971)[SEQ ID NO.4](“NTP-106A”)。

图5：显示106个氨基酸的神经丝状蛋白样蛋白质的完整氨基酸序列(NCBIEntrez-蛋白质数据库登录号#XP_039102 PID g18599339)[SEQ ID NO.5](“NTP-106B”)。

图6：显示98个氨基酸的神经丝状蛋白的完整氨基酸序列(获自美国专利号5,830,670、5,948,634和5,948,888的序列30；NCBI Entrez-蛋白质数据库登录号#AAE25445，PID g10048538)[SEQ ID NO.6](“NTP-98”)。

图7：显示75个氨基酸的神经丝状蛋白的完整氨基酸序列(获自美国专利号5,830,670、5,948,634和5,948,888的序列48；NCBI Entrez-蛋白质数据库登录号#AAE25448，PID g10048541)[SEQ ID NO.7](“NTP-75”)。

图8：显示68个氨基酸的神经丝状蛋白的完整氨基酸序列(获自美国专利号5,830,670、5,948,634和5,948,888的序列36；NCBI Entrez-蛋白质数据库登录号#AAE25446，PID g10048539)[SEQ ID NO.8](“NTP-66”)。

图9：显示61个氨基酸的神经丝状蛋白样蛋白质的完整氨基酸序列(NCBIEntrez-蛋白质数据库登录号#AAH02534，PID g12803421)[SEQ ID NO.9](“NTP-61”)。

优选实施方案的详细说明

除非另有说明，本文使用的术语和词组按如下定义。

术语“AD7c-NTP”指约41kD蛋白质和基因以及编码它的核酸序列，描述是de la Monte等，J.Clin.Invest.，100：3093-104(1997)，美国专利号5,948,634；5,948,888和5,830,670的序列120和121以及GenBank#AF010144中，其核酸和氨基酸序列示于图1。术语“AD7c-NTP”也包括AD7c-NTP的生物活性片段、变体、衍生物、同源物和模拟物。

术语“NTP”或“神经丝状蛋白”指神经丝状蛋白和相关分子(包括胰丝状蛋白)和编码这些蛋白质的核酸序列，且包括(但不限于)下列蛋白质和编码这些蛋白质的氨基酸序列的核酸序列：

(a)AD7c-NTP；

(b)～42、～26、～21、～17、～14和～8kD种类的神经丝状蛋白，描述见于美国专利号5,948,634；5,948,888；5,830,670和6,071,705和de la Monte等，J.Neuropathol.Exp.Neurol.，55(10)：1038-50(1996)，de la Monte等，J.Neurol.Sci.，138(1-2)：26-35(1996)；de la Monte等，J.Neurol.Sci.，135(2)：118-25(1996)；de la Monte等，J.Clin.Invest.，100：3093-3104(1997)；de la Monte等，Alz.Rep.，2：327-332(1999)；

(c)单克隆抗体#2特异性识别的蛋白质保存于美国典型培养物保藏所，Manassas，Va.，登录号HB-12546，或单克隆抗体#5特异识别的蛋白质保存于美国典型培养物保藏所，Manassas，Va.，登录号HB-12545；

(d)由AD7c-NTP基因所编码的蛋白质；

(e)122个氨基酸神经丝状蛋白，描述见美国专利号5,830,670、5,948,634和5,948,888的序列40，并在NCBI Entrez-蛋白质登录号#AAE25447，PID g10048540中列出，其氨基酸序列示于图2(“NTP-122”)；

(f)NCBI Entrez-蛋白质登录号#XP_032307，PID g14725132中列出的122个氨基酸神经丝状蛋白，其氨基酸序列示于图3(“NTP-112”)；

(g)NCBI Entrez-蛋白质登录号#AAH14951 PID g15928971中列出的106个氨基酸神经丝状蛋白，其氨基酸序列示于图4(“NTP-106A”)；

(h)NCBI Entrez-蛋白质登录号#XP_039102 PID g18599399中列出的106个氨基酸神经丝状蛋白，其氨基酸序列示于图5(“NTP-106B”)；

(i)98个氨基酸神经丝状蛋白，描述见美国专利号5,830,670、5,948,634和5,948,88的序列30，并在NCBI Entrez-蛋白质登录号#AAE25445，PIDg10048538中列出，其氨基酸序列示于图6(“NTP-98”)；

(j)75个氨基酸神经丝状蛋白，描述见美国专利号5,830,670、5,948,634和5,948,888的序列48，并在NCBI Entrez-蛋白质登录号#AAE25448，PIDg10048541中列出，其氨基酸序列示于图7(“NTP-75”)；

(k)68个氨基酸神经丝状蛋白，描述见美国专利号5,830,670、5,948,634和5,948,888的序列36，并在NCBI Entrez-蛋白质登录号#AAE25446，PIDg10048539中列出，其氨基酸序列示于图8(“NTP-68”)；

(l)在NCBI Entrez-蛋白质登录号#AAH02534，PID g12803421中列出的61个氨基酸的神经状蛋白样蛋白质，其氨基酸序列示于图9(“NTP-61”)；

(m)胰丝状蛋白；

(n)在美国专利号6,071,705中描述的神经胰丝状蛋白(nPTP)；

(o)杂交瘤产生的抗体特异性识别的蛋白质，这些杂交瘤为保存于美国典型培养物保藏所的HB 9934、HB 9935和HB 9936。

术语“NTP肽”所指的肽包括对应于NTP的至少一部分氨基酸序列或NTP片段的氨基酸序列，除非另有说明，还包括这些肽的同源物、衍生物、变体、融合蛋白和肽模拟物。术语“NTP肽”还包括(但不限于)美国专利申请序列号10/092,934个10/153334中特别列出的肽。术语“NTP肽”优选包括(但不限于)NTP的以下氨基酸序列：

a)NTP肽#1[SEQ ID NO.10]，AD7c-NTP p239-243

SSWDY

Ser-Ser-Trp-Asp-Tyr

b)NTP肽#2[SEQ ID NO.11]，AD7c-NTP p31-39

PASASPVAG

Pro-Ala-Ser-Ala-Ser-Pro-Val-Ala-Gly

c)NTP肽#3[SEQ ID NO.12]，AD7c-NTP p14-24

GAISAHRNLRL

Gly-Ala-Ile-Ser-Ala-His-Arg-Asn-Leu-Arg-Leu

d)NTP肽#4[SEQ ID NO.13]，AD7c-NTP p53-58

FFLVEM

Phe-Phe-Leu-Val-Glu-Met

e)NTP肽#5[SEQ ID NO.14]，AD7c-NTP p208-216

SVTQAGVQW

Ser-Val-Thr-Gln-Ala-Gly-Val-Gln-Trp

f)NTP肽#6[SEQ ID NO.15]，NTP-122p106-122

IDQQVLSRIKLEIKRCL

Ile-Asp-Gln-Gln-Val-Leu-Ser-Arg-Ile-Lys-Leu-Glu-Ile-Lys-Arg-Cys-Leu

g)NTP肽#7[SEQ ID NO.16]，NTP-122p111-119

LSRIKLEIK

Leu-Ser-Arg-Ile-Lys-Leu-Glu-Ile-Lys

并包括这些特别列出的NTP肽的同源物、衍生物、变体、片段、融合蛋白和肽模拟物。

术语“相关蛋白”指含有一种或多种与一种或多种NTP肽相同、非常类似或同源的氨基酸序列的蛋白质。

表述“相关肽”指由与所述相关蛋白的至少一部分氨基酸序列相对应的氨基酸序列构成的肽，并包括这种肽的同源物、变体、融合蛋白、反-D肽和肽模拟物。表述“相关肽”还优选包括(但不限于)所述相关蛋白的以下氨基酸序列：

(a)相关肽#1[SEQ ID NO.17]，暂时的受体潜在通道6，δ变体(NCBI登录号CAC01686，PID g9716913)，p356-377

GDHGRPNLSRLKLAIKYEVKKM

Gly-Asp-His-Gly-Arg-Pro-Asn-Leu-Ser-Arg-Leu-Lys-Leu-Ala-Ile-Lys-Tyr-Glu-Val-Lys-Lys-Met

(b)相关肽#2[SEQ ID NO.18]，假定的钙通道(NCBI登录号NP_065122，PIDg9966865)，p345-360

QQSIAVKFLAVFGVSI

Gln-Gln-Ser-Ile-Ala-Val-Lys-Phe-Leu-Ala-Val-Phe-Gly-Val-Ser-Ile

(c)相关肽#3[SEQ ID NO.19]，trp-相关蛋白4截短的γ变体(NCBI登录号AF063825_1，PID g6665596)，p337-357

GLLFPVFSVCYLIAPKSPLGL

Gly-Leu-Leu-Phe-Pro-Val-Phe-Ser-Val-Cys-Tyr-Leu-Ile-Ala-Pro-Lys-Ser-Pro-Leu-Gly-Leu

并包括这些特别列出的相关肽的同源物、衍生物、变体、片段、融合蛋白和肽模拟物。

表述“细胞死亡肽”指已证明是造成细胞死亡的有效制剂的相关蛋白或相关肽。

术语“片段”指由NTP蛋白、NTP肽、相关蛋白或相关肽的氨基酸序列的连续亚序列构成的蛋白质或多肽，包括天然产生的片段，如剪接变体和体内由于蛋白酶水解活性天然产生的片段。这种片段可在氨基末端、羧基末端和/或中间(如自然剪接)截短。这种片段可以用或不用氨基末端甲硫氨酸制备。术语“片段”包括相同NTP蛋白或NTP肽，或相关蛋白或相关肽的片段，可以相同或不同，共有或没有毗连的氨基酸序列，直接或通过接头连接在一起。

术语“变体”指蛋白质或多肽，其中与NTP蛋白、NTP肽、相关蛋白或相关肽的氨基酸序列相比，存在一个或多个氨基酸取代、缺失和/或插入，包括天然产生的NTP蛋白、NTP肽、相关蛋白或相关肽的等位基因变体或者交替剪接变体。术语“变体”包括在肽序列中的一个或多个氨基酸用类似或同源氨基酸或不相似氨基酸的置换。氨基酸可在许多等级上分为类似或同源氨基酸(Gunnar von Heijne，《分子生物学的序列分析》(Sequence Analysis in Molecular Biology)，123-39页Academic Press，纽约，NY 1987.)优选的变体包括一个或多个氨基酸位置的丙氨酸取代。其它优选的取代包括对蛋白质的整体净电荷、极性或疏水性影响小或没有影响的保守性取代。保守性取代列于下表2中。

表2

保守性氨基酸取代

碱性：精氨酸

赖氨酸

组氨酸

酸性：谷氨酸

天冬氨酸

无电荷极性：谷氨酰胺

天冬酰胺

丝氨酸

苏氨酸

酪氨酸

非极性：苯丙氨酸

色氨酸

半胱氨酸

甘氨酸

丙氨酸

缬氨酸

脯氨酸

甲硫氨酸

亮氨酸

异亮氨酸

表3列出氨基酸取代的另一种方案：

表3

原来的残基取代

丙氨酸甘氨酸；丝氨酸

精氨酸赖氨酸

天冬酰胺谷氨酰胺；组氨酸

天冬氨酸谷氨酸

半胱氨酸丝氨酸

谷氨酰胺天冬酰胺

谷氨酸天冬氨酸

甘氨酸丙氨酸；脯氨酸

组氨酸天冬酰胺；谷氨酰胺

异亮氨酸亮氨酸；缬氨酸

亮氨酸异亮氨酸；缬氨酸

赖氨酸精氨酸；谷氨酰胺；谷氨酸

甲硫氨酸亮氨酸；酪氨酸；异亮氨酸

苯丙氨酸甲硫氨酸；亮氨酸；酪氨酸

丝氨酸苏氨酸

苏氨酸丝氨酸

色氨酸酪氨酸

酪氨酸色氨酸；苯丙氨酸

缬氨酸异亮氨酸；亮氨酸

其它变体可由保守性较小的氨基酸取代组成，如选择的残基更显著的不同在于它们对维持(a)取代区域中多肽主链结构的作用，例如片层或螺旋构型，(b)靶位点分子的电荷或疏水性，(c)侧链大小。预期通常对功能有更显著作用的取代是(a)甘氨酸和/或脯氨酸被另一种氨基酸取代或缺失或插入；(b)亲水性残基如丝氨酰或苏氨酰取代(或被)疏水性残基，如亮氨酰、异亮氨酰、苯丙氨酰、缬氨酰或丙氨酰；(c)半胱氨酸残基取代(或被)任何其它残基；(d)具有正电侧链的残基如赖氨酰、精氨酰或组氨酰取代(或被)具有负电荷的残基如谷氨酰或天冬氨酰；或(e)具有大侧链的残基如苯丙氨酸取代(或被)没有这种侧链的残基如甘氨酸。其它变体包括设计为产生新的糖基化和/或磷酸化位点的，或设计为缺失现有糖基化和/或磷酸化位点的残基。变体包括糖基化位点、蛋白水解切割位点和/或半胱氨酸残基上的至少一个氨基酸取代。变体还包括在接头肽上NTP蛋白、NTP肽、相关蛋白或相关肽氨基酸序列之前或之后具有其它氨基酸残基的NTP蛋白、NTP肽、相关蛋白或相关肽。例如，可将半胱氨酸残基加在相关肽的氨基和羧基末端通过形成二硫键使相关肽环化。术语“变体”还包括具有相关蛋白或相关肽的氨基酸序列的多肽，它们在相关蛋白或相关肽的3′或5′末端侧接有至少1个和多达25个或更多额外的氨基酸。

术语“衍生物”指化学修饰的蛋白质或多肽，它们通过天然过程如加工和其它翻译后修饰而被化学修饰，也可通过化学修饰技术加入一个或多个聚乙二醇分子、糖、磷酸盐和/或其它这类分子，其中这类分子不是天然结合于野生型NTP蛋白或肽的分子。衍生物包括盐。这种化学修饰描述可见基础教材和更详细的专论以及大量研究文献中，它们是本领域技术人员所熟知的。将会理解的是，相同类型的修饰可能以相同或不同程度存在于某给定蛋白质或多肽的一些位点上。同样，给定蛋白质或多肽可包含许多种类的修饰。这些修饰可发生在蛋白质或多肽的任何地方，包括肽主链、氨基酸侧链和氨基或羧基末端。这些修饰包括例如乙酰化、酰化、ADP-核糖基化、酰胺化、黄素的共价结合、血红素部分的共价结合、核苷酸或核苷酸衍生物的共价结合、脂质或脂质衍生物的共价结合、磷脂酰肌醇的共价结合、交联、环化、二硫键形成、脱甲基化、形成共价交联、形成半胱氨酸、形成焦谷氨酸、甲酰化、γ-羧基化、糖基化、GPI锚形成、羟基化、碘化、甲基化、豆蔻酰化、氧化、蛋白酶解加工、磷酸化、异戊二烯化、外消旋化、糖基化、脂质结合、硫酸化、谷氨酸残基的γ-羧基化、羟基化和ADP-核糖基化、硒基化(selenoylation)、转运RNA介导的氨基酸加入蛋白质，如精氨酰化和泛素化。参见例如《蛋白质-结构和分子性质》(Proteins-Structure And Molecular Properties)，第二版，T.E.Creighton，W.H.Freeman和Company，纽约(1993)和Wold，F.，“翻译后蛋白质修饰：观点和前景”(Posttranslational Protein Modifcation：Perspective andProspects)，《蛋白质的翻译后共价修饰》(Posttranslational Convalent Modification ofProteins)，1-12页，B.C.Johnson编，Academic Press，纽约(1983)；Seifter等，Meth.Enzymol.182：626-646(1990)和Rattan等，“蛋白质合成：翻译后修饰和衰老”(Posttranslational Modifcation and Aging)，Ann.N.Y.Acad.Sci.663：48-62(1992)。术语“衍生物”包括化学修饰导致蛋白质或多肽变成分支状或者有或没有分支的环状。环状、分支状和分支环状蛋白质或多肽可能由翻译后的天然加工产生并也可完全由合成方法产生。

术语“同源物”指蛋白质，其与NTP蛋白、NTP肽、相关蛋白或相关肽的氨基酸序列，根据常用于比较两种多肽的氨基酸位置相似性的标准方法测定至少有60％相同。两种蛋白质之间的相似性或相同性程度可用已知方法计算，包括但不限于以下所描述的那些方法：《计算分子生物学》(Computational Molecular Biology)，Lesk，A.M.编，牛津大学出版社，纽约，1988；《生物计算：信息学和基因组计划》(Biocomputing：Informatics and Genome Projiects)，Smith，D.W.编，Academic Press，纽约，1993；《序列数据的计算机分析》(Computer Analysis of Sequence Data)，第I部分，Griffin，A.M.和Griffin，H.G.编，Humana Press，新泽西州，1994)；《分子生物学序列分析》(Sequence analysis in Molecular Biology)，von Heinje，G.，AcademicPress，纽约，1987)；《序列分析引物》(Sequence analysis Primery)，Gribskov，M.和Devereux，J.编，M Stockton Press，纽约，1991；Carillo H.和Lipman，D.，SIAM，J.Applied Math.，48：1073(1988)。设计了确定相同性的优选方法来给出测试序列之间的最大匹配。在公众可得到的计算机程序中编纂了确定相同性和相似性的方法。

用于确定两种序列之间相同性和相似性的优选计算机程序方法，包括但不限于GCG程序包(Devereux，J.等，Nucleic Acids Research，12(1)：387(1984))，BLASTP，BLASTN和FASTA，Atschul，S.F.等，J.Molec.Biol.，215：403-410(1990)。BLASTX程序公众可从NCBI和其它来源获得(BLAST手册，Altschul，S.等，NCBI NLM NIHBethesda，Md.20894；Altschul，S.等，J.Mol.Biol.，215：403-410(1990)。例如采用计算机算法如GAP(遗传学计算机组，University of Wisconsin，Madison，Wis.)，排列对比两种待测定的蛋白质或多肽的序列相同性百分比用于最佳匹配它们各自的氨基酸(“匹配范围”通过算法确定)。

空隙开放罚分(gap opening penalty)(计算为3x倍平均对角线；“平均对角线”是所用比较矩阵的对角线平均值；“对角线”是通过具体比较矩阵赋予各优选氨基酸的评分或数值)和空隙延伸罚分(gap extension penalty)(通常是空隙开放罚分的1/10倍)以及比较矩阵例如PAM250或BLOSUM 62可与此算法结合使用。此算法也可使用标准的比较矩阵(PAM250比较矩阵参见Dayhoff等，《蛋白质序列和结构图谱集》(Atlas ofProtein Sequence and Structure)，第5卷，增补本3[1978]；BLOSUM62比较矩阵参见Henikoff等，Proc.Natl.Acad.Sci.USA，89：10915-10919[1992])。然后用该算法计算相同性百分比。同源物与NTP蛋白、NTP肽、相关蛋白或相关肽相比，通常具有一个或多个氨基酸取代、缺失和/或插入。

术语“肽模拟物”或“模拟物”指能模拟肽或蛋白质的生物活性但在化学性质上不再是肽的生物活性化合物，即它们不再含任何肽键(即氨基酸间的酰胺键)。这里术语肽模拟物用于更广泛含义，包括性质上不再完全是肽的分子如假肽、半肽和拟肽(peptoid)。此广泛含义上的肽模拟物的例子(其中肽的一部分被缺乏肽键的结构取代)在下面描述。无论完全是或部分是非肽，本发明的肽模拟物提供了反应性化学组成成分的空间排列，肽模拟物所依据的这种排列非常类似于NTP肽相关蛋白或相关肽中活性基团的三维排列。由于这种相似的活性位点的几何结构，肽模拟物对生物系统的作用类似于NTP肽、相关蛋白或相关肽的生物活性。

本发明的肽模拟物优选在三维形状和生物活性上基本上类似于本文所述的NTP肽、相关蛋白或相关肽。本领域已知的结构上修饰肽以产生肽模拟物的方法的例子，包括倒置主链手性中心产生D-氨基酸残基结构，具体是在N-末端，使对蛋白酶降解的稳定性提高而对活性没有不利地影响。在论文“含氚D-丙氨酸¹-肽T结合”，Smith C.S.等，Drug DevelopmentRes.，15，371-379页(1988)中描述了一个例子。第二种方法是改变稳定性所需的环状结构，如N到c的链间二酰亚胺和内酰胺(Ede等，Smith和Rivier编，《肽：化学和生物学》(Peptides：Chemistry andBiology)，Escom，Leiden，1991，268-270页)。例子见构型限制的胸腺五肽样化合物，如美国专利号4,457,489(1985)，Goldstein，G.等所公开的那样，其内容全部纳入本文供参考。第三种方法是用对蛋白水解有抗性的假肽键替换相关蛋白或相关肽中的肽键。

已报道了一些假肽键一般不影响肽的结构和生物活性。此方法的一个例子是取代逆一反转假肽键(“胸腺五肽的生物活性逆反转同源物”)(Biologically activeretroinverso analogue of thymopentin)，Sisto A等，Rivier，J.E.和Marshall，G.R.编，“肽、化学、结构和生物学”(Peptides，Chemistry，Structure and Biology)，Escom，Leiden，1990，722-773页)和Dalpozzo等(1993)，Int.J.Peptide Protein Res.，41：561-566，纳入本文供参考)。根据此修饰，肽的氨基酸序列可能与上述NTP肽、相关蛋白或相关肽的序列相同，除了一个或多个肽键被逆转化假肽键所取代。优选大部分N-末端肽键被取代，由于这种取代将赋于N-末端对抗外肽酶的蛋白水解抗性。也可用其它类似结构的化学基团替代氨基酸的化学基团进行修饰。另一种已知可提高对抗酶裂解的稳定性而生物活性没有或很少损失的合适假肽键，是还原型电子等排物(isostere)假肽键(Couder等(1993)，Int.J.Peptide Protein Res.，41：181-184，全部纳入本文供参考)。

因此，这些肽的氨基酸序列可能与NTP肽、相关蛋白或相关肽的序列相同，除了一个或多个肽键被电子等排物假肽键替代外。本文所用术语“氨基酸序列”优选指至少2个氨基酸的序列，优选至少4个，更优选至少5个。优选大部分N-末端肽键被取代，因为这种取代可赋予N-末端对抗外肽酶的蛋白水解抗性。合成具有一个或多个还原型电子等排的假肽键的肽是本领域已知的(Couder等，上面所引用)。另一个例子包括导入酮亚甲基键或甲硫键来替代肽键。

NTP肽、相关蛋白或相关肽的拟肽衍生物代表了另一类肽模拟物，它们保留了生物活性的重要结构决定簇，但去除了肽键，从而赋予对蛋白水解的抗性(Simon等，1992，Proc.Natl.Acad.Sci.USA，89：9367-9371，全部纳入本文供参考)。拟肽是N-取代的甘氨酸的寡聚物。已报道了一些N-烷基基团，各对应于天然氨基酸的侧链(Simon等，1992，见上面所引用)。NTP肽、相关蛋白或相关肽的一些或所有的氨基酸可用对应于被替代氨基酸的N-取代甘氨酸所替代。

术语“肽模拟物”或“模拟物”还包括反-D肽和下面定义的对映异构体。

术语“反-D肽”指与NTP肽、相关蛋白或相关肽的L-氨基酸序列相比，由反向顺序排列的D-氨基酸组成的生物活性蛋白质或肽。因此，L-氨基酸NTP肽、相关蛋白或相关肽的羧基末端残基成为D-氨基酸肽的氨基末端。例如，NTP肽、SSWDY变成T_dD_dW_dS_dS_d，其中D_d、S_d、W_d和Y_d是分别对应于L-氨基酸D、S、W和Y的D-氨基酸。

术语“对映异构体”指一种生物活性蛋白质或肽，其中NTP肽、相关蛋白或相关肽的氨基酸序列中一个或多个L-氨基酸残基被相应的D-氨基酸残基替代。

本文所描述的氨基酸和氨基酸残基可参考下表提供的公众接受的单字母或三字母码。

表1

氨基酸单字母符三字母符

丙氨酸 A Ala

精氨酸 R Arg

天冬酰胺 N Asn

天冬氨酸 D Asp

半胱氨酸 C Cys

谷氨酰胺 Q Gln

谷氨酸 E Glu

甘氨酸 G Gly

组氨酸 H His

异亮氨酸 I Ile

亮氨酸 L Leu

赖氨酸 K Lys

甲硫氨酸 M Met

苯丙氨酸 F Phe

脯氨酸 P Pro

丝氨酸 S Ser

苏氨酸 T Thr

色氨酸 W Trp

酪氨酸 Y Tyr

缬氨酸 V Val

本发明涉及含有如本发明以上定义的细胞死亡肽的组合物。优选的细胞死亡肽与NTP肽类似或同源。然而，使用基于相关蛋白的部分或片段的细胞死亡肽也包括在本发明范围之内。例如，在许多人类和非人蛋白质(“相关蛋白”)中也发现了AD7c-NTP肽序列和类似的变体和同源物。特别是，AD7c-NTP基因含有Alu-型序列，它与那些也在人类和其它灵长类基因组的其它基因中发现的序列非常类似。

因此，可以理解，一些(如果不是全部)相关蛋白也将被证明是造成细胞死亡的有效制剂，因为它们含有肽序列与AD7c-NTP肽同源或非常类似(“相关肽”)。同样，此领域的一般技术人员可以基于任何相关蛋白的氨基酸序列来合成特定的相关肽，这些相关蛋白质是造成细胞死亡的有效制剂，并测试它们作为造成细胞死亡制剂的效力。

衍生自相关蛋白(它们被发现是造成细胞死亡的有效制剂)的其它肽序列也是可造成细胞死亡的有效制剂。此领域的一般技术人员无需过多实验就可合成跨越所述蛋白质整个氨基酸序列的有效相关蛋白的片段，以便鉴定其它有效的肽序列。

一些相关蛋白包括以下已知含有与NTP肽序列相同、非常类似或同源的氨基酸的蛋白质。

蛋白质序列蛋白质的氨基酸序列

鉴定编号编号

(PID)

g10121865 20 MEVSPLQPVNENMQVN KIKKNEDAKKRLSVER IYQKKTQLEHILLRPD

TYIGSVELVTQQMWVY DEDVGINYREVTFVPG LYKIFDEILVNAADNK

QRDPKMSCIRVTIDPE NNLISIWNNGKGIPVV EHKVEKMYVPALIFGQ

LLTSSNYDDDEKKVTG GRNGYGAKLCNIFSTK FTVETASREYKKMFKQ

TWMDNMGRAGEMELKP FNGEDYTCITFQPDLS KFKMQSLDKDIVALMV

RRAYDIAGSTKDVKVF LNGNKLPVKGFRSYVD MYLKDKLDETGNSLKV

IHEQVNHRWEVCLTMS EKGFQQISFVNSIATS KGGRHVDYVADQIVTK

LVDVVKKKNKGGVAVK AHQRELCNGAILAHCN LRLMGSSDSPASASRV

AGIAGGCHHTQLIFVF LVETGFHHVGQAGLER LTSGDPPASASQSSGI

TDVKVKNHWMIFVNAL IENPTFDSQTKENMTL QPKSFGSTCQLSEKFI

KAAIGCGIVESILNWV KFKAQVQLNKKCSAVK HNRIKGIPKLDDANDA

GGRNSTECTLILTEGD SAKTLAVSGLGVVGRD KYGVFPLRGKILNVRE

ASHKQ

g10257409 21 MTGDKGPQRLSGSSYG SISSPTSPTSPGPQQA PPRETYLSEKIPIPDT

KPGTFSLRKLWAFTGP GFLMSIAFLDPGNIES DLQAGAVAGFKLLWVL

LWATVLGLLCQRLAAR LGVVTGKDLGEVCHLY YPKSESRSVAQSGVQW

CDVSSLQPLPPRCPAP SSG

g10433567 22 MMLSVQENVHRCICKH YAPPTAPHLFFETESH SVTQAGVQWCDLGSLQ

PSPPGFKQFSCLSLSR SWDYRRVPLCLANFIV FLVETGFCRVGQAGLK

LLTSSDLPASACQSAG DYRHEPLRLALTLCHF ISRTCTSVDFYICRDL

ERIPHGH

g10434441 23 MISAHRNLHLPGSSNS PASAFLSSWDYRHVPP CPANVVFLVEMGFLHV

GQAGLELPTSDDPPTL ASQSAGITGVSHRTWQ EFASLTVSQAVLRMLV

WGPQFENHCSKLLMAS EGDSSLVFFLYPLSNL N

g10436387 24 MQGSHSAVQAGVWWCH HDSLQPWPPGLRRSSC LSLQSLWDYRSLALSL

RLACNGTTSAHCDLCL LSSSDSPASASQVAGI TGEKTAEPHKAHAAQG

ERHLSSHMSPDENMTE KFCPGPRASFHLRILA ASRHLVKRLLNEYTVT

VLRDKSYLRNN

g10437485 25 MKNYYYFLGQGLTLSP RLECSSTISAHCNLHL LGSSNSPVAASPVAGT

TGTCHHDWLIFVFLVE TGFHHIGQTGLEFLTS GDPPTLASKSAGITGV

SHCAWPTFLLNDMRHS FNKNLVIIFYVPAIS

g10441986 26 MRRELLAGILLRITFN FFLFFFLPFPLVVFFI YFYFYFFLEMESHYVA

QAGLELLGSSNPPASA SLVAGTLSVHHCACFE SFTKRKKKLKKAFRFI

QCLLLGLLKVRPLQHQ GVNSCDCERGYFQGIF MQAAPWEGT

g10945428 27 MSKTLKKKKHWLSKVQ ECAVSWAGPPGDFGAE IRGGAERGEFPYLGRL

REEPGGGTCCIVSGKA PNPSDVLLEVNGTPVS GLTNRDTLAVIRHFRE

PIRLKTVKPGKVINKD LRHYLSLQFQKGSIDH KLQQVIRDNLYLRTIP

CTTRAPRDGEVPGVDY NFISVEQFKALEESGA LLESGTYDGNFYGTPK

PPAEPSPFQPDPVDQV LFDNEFDAESQRKRTT SVSKMERMDSSLPEEE

EDEDKGAINGSGNAEN RERHSESSDWMKTVPS YNQTNSSMDFRNYMMR

DETLEPLPKNWEMAYT DTGMIYFIDHNTKTTT WLDPRLCKKAKAPEDC

EDGELPYGWEKIEDPQ YGTYYVDFTLVAQAGV QWHDLGSLQPPPPGFN

HLNQKTQFENPVEEAK RKKQLGQVEIGSSKPD MEKSHFTRDPSQLKGV

LVRASLKKSTMGFGFT IIGGDRPDEFLQVKNV LKDGPAAQDGKIAPGD

VIVDINGNCVFGHTHA DVVQMFQLVPVNQYVN LTLCRGYPLPDDSEDP

VVDIVAATPVINGQSL TKGETCMNPQDFKPGA MVLEQNGKSGHTSTGD

GLNGPSDASEQRVSMA SSGSSQPELVTIPLIK GPKGFGFAIADSPTGQ

KVKMILDSQWCQGLQK EDIIKEIYHQNVQNLT HLQVVEVLKQFPVGAD

VPLLILRGGPPSTTKT AKMKTDKKENAGSLEA INEPIPQPMPFPPSII

RSGSPKLDPSEVYLKS KTLYEDKPPNTKDLDV FLRKQESGFGFRVLGG

DGPDQSIYIGAIIPLG AAEKDGRLRAADELMC IDGIPVKGKSHKQVLD

LMTTAARNGHVLLTVR RKIFYGEKQPEDDSSQ AFISTQNGSPRLNRAE

VPARPAPQEPYDVVLQ RKENEGFGFVILTSKN KPPPGVIPHKIGRVIE

GSPADRCGKLKVGDHI SAVNGQSIVELSHANI VQLIKDAGVTVTLTVI

AEEEHHGPPSGTNSAR QSPALQHRPMGQSQAN HIPGDRSALEGEIGKD

VSTSYRHSWSDHKHLA QPDTAVISVVGSRHNQ NLGCYPVELERGPRGF

GFSLRGGKEYNMGLFI LRLAEDGPAIKDGRIH VGDQIVEINGEPTQGI

THTRAIELIQAGGNKV LLLLRPGTGLIPDHGL APSGLCSYVKPEQH

g1117849 28 MADDQGCIEEQGVEDS ANEDSVDAKPDRSSFV PSLFSKKKKNVTMRSI

KTTRDRVPTYQYNMNF EKLGKCIIINNKNFDK VTGMGVRNGTDKDAEA

LFKCFRSLGFDVIVYN DCSCAKMQDLLKKASE EDHTNAACFACILLSH

GEENMESCSVTQAGVQ RRDLGRLQPPPPRLAE GPSLMMASRPTRGPSM

TQMLILDTRSQWKLTS SSPIPRFQAITRGGAQ EEAPGLCKPSAPSWRS

TEKTWKSCRSSPG

g11493409 29 MGLSIASHFGLLIKKV ERNILFFFRRSLALCQ AGVQWRYLSQLTAASA

SWVQAILCLSLPSSWD YRHMPPRPANFCILSR DGISPCWPGWSRSLDL

VIRPPRPPKVLRLQA

g11493483 30 MQIIFFFLFLRWSFTL VAQAGVQWRDLSSPQP PPPRFKRFSCLSPPSS

WDYRHAPPHPANFVFL VETGFLRVGQAGLELL TSGDPPASASQSAGIT

GVSHHTQPDANNFLRK LFQKLF

g12654881 31 MGHPRAIQPSVFFSPY DVHFLLYPIRCPYLKI GRFHIKLKGLHFLFSF

LFFFFETQSHSVTRLE CSGTISAHCNLCLPGS SNSPASASQVAGTTGT

CHHAQLIFVFLAEMGF HHIGQDGLDLNLVIHP PRSPKALGLQA

g12803929 32 MPNHYSFCFCFCFCFR RSLALSPRLECSGAIL AHGKLHLPGSRHSPAS

ASPVAGTKGARHHARL IFLYF

g13359183 33 LFTNSPFSLLSPAQWL CFGTHLGHVQSVSHLQ WEGSVQESLRSVRNSR

CALPMLSAPCSLSLHF LLFSLSPFFFFEIRVL LYRQAGVQWCYLGSLQ

PLPPGFKQFSCLSYPS SWDYRRPPPRQANFCI FSTDGVSPCWPRWSLS

LDLMIRPPQPPEVLGL QV

g13375624 34 MGRLVLLWGAAVFLLG GWMALGQGGAEGVQIQ IIYFNLETVQVTWNAS

KYSRTNLTFHYRFNGD EAYDQCTNYLLQEGHT SGCLLDAEQRDDILYF

SIRNGTHPVFTASRWM VYYLKPSSPKHVRFSW HQDAVTVTCSDLSYGD

LLYEVQYRSPFDTEWQ TQSRSVTQAGVQWCDL CLLQPSPPRFKRFSCL

SLPSSWDYRHPPPRLA NFCIISRDGVSPCWPG WSRTCDLR

g13376528 35 MEFLKVARRNKREQLE QIQKELSVLEEDIKRV EEMSGLYSPVSEDSTV

PQFEAPSPSHSSIIDS TEYSQPPGFSGSSQAG VQWRYLGSLQPPPPRY

KRFSCLTLPSSWDYRR LPPHLTKKQPWYNSTL ASRRKRLTAHFEDLEQ

CYFSTRMSRISDDSRT ASQLDEFQECLSKFTR YNSVRPLATLSYASDL

YNGSSIVSSIEFDRDC DYFAIAGVTKKIKVYE YDTVIQDAVDIHYPEN

EMTCNSKISCISWSSY HKNLLASSDYEGTVIL WDGFTGQRSKVYQEHE

KRCWSVDFNLMDPKLL ASGSDDAKVKLWSTNL DNSVASIEAKANVCCV

KFSPSSRYHLAFGCAD HCVHYYDLRNTKQPIM VFKGHRKAVSYAKFVS

GEEIVSASTDSQLKLW NVGKPYCLRSFKGHIN EKNFVGLASNGDYIAC

GSENNSLYLYYKGLSK TLLTFKFDTVKSVLDK DRKEDDTNEFVSAVCW

RALPDGESNVLIAANS QGTIKVLELV

g13376550 36 MGSYFVARAGCKLLGL KGTSHFSLPKCRNCRR EPLPGLFFLFFVFFFL

RRSLALSPRLECSGAI VAHCKLGLPGSLHSPA SASQVAGTIGTCHNTR

IIFCILVETGFHRVSQ DGVDLLTL

g13430856 37 MDCGSVGGQRTQRLPG RQRLLFLPVGLSGRPG GSETSARRCPSALSDG

LGALRPRAPAARGGVS RASPLLLLLLVPSPRL AAAAPRRQLGDWERSR

LGYAAPPAGRSGAWRC SPGVAAAAGALPQYHG PAPALVSCRRELSLSA

GSLQLERKRRDFTSSG SRKLYFDTHALVCLLE DNESHSFIQAGVQWHS

LGLLQPPPPGFKRSSH LILLSSWDYRHAPPHL DNFSVFLLETGFHHVG

QAGLKLLTSSDPPTLA S

g13431835 38 MSPATTGTFLLTVYSI FSKVHSDRNVYPSAGV LFVHVLEREYFKGEFP

PYPKPGEISNDPITFN TNLMGYPDRPGWLRYI QRTPYSDGVLYGSPTA

ENVGKPTIIEITAYNR RTFETARHNLIINIMS AEDFPLPYQAEFFIKN

MNVEEMLASEVLGDFL GAVKNVWQPERLNAIN ITSALDRGGRVPLPIN

DLKEGVYVMVGADVPF SSCLREVENPQNQLRC SQEMEPVITCDKKFRT

QFYIDWCKISLVDKTK QVSTYQEVIRGEGILP DGGEYKPPSDSLKSRD

YYTDFLITLAVPSAVA LVLFLILAYIMCCRRE GVEKRNMQTPDIQLVH

HSAIQKSTKELRDMSK NREIAWPLSTLPVFHP VTGEIIPPLHTDNYDS

TNMPLMQTQQWSFAPV AQAGVQWRDLGSLQPP PPRNLPHQTQIPQQQT

TGKWYP

g13435153 39 MLGLRKAAAISLLLRN VGLQLATLLMSQKKLG FCGNFLFLNLAIIQTK

ISSSFFFFLRQSLTLS PRLECNGAISAHCHLR LPDSSNSPASASQVTG

ITGSHHHAWLIFVFLV ETGFCHVGQDGLELLT SGDPPASASQSAGITG

MSHHTWPTDLFFKTVL PARLGLWDSSV

g13489079 40 MHAVPRGFGKKVRVGV QSCPSPFSGQACPQPS SVFWSLLKNLPFLEHL

ELIGSNFSSAMPRNEP AIRNSLPPCSRAQSVG DSEVAAIGQLAFLRHL

TLAQLPSVLTGSGLVN IGPQCQQLRSLSLANL GMMGKVVYMPALSDML

KHCKRLRDLRLEQPYF SANAQFFQALSQCPSL QRLCLVSRSGTLQPDA

VLAFMARCLQVVMCHL FTGESLATCKSLQQSL LRRWGEVTGRRPQLFT

ELREEPSARTSRATGR RQPCLPDSGVVCCPCG RPLAVSGIILVGVSPS

LVVKTTCVYRVLFKNL DYASIFFLVCLFETES HSVVQAGVQWRDLSSL

QPLLSGLQPQPPEQLE NELEIGFSYCFVI

g13489081 41 MEEDEFIGEKTFQRYC AEFIKHSQQIGDSWEW RPSKDCSDGYMCKIHF

QIKNGSVMSHLGASTH GQTCLPMEVKSCSVTQ AGVQLRDLSSLQPPPS

GFKQFSCLSLPSNWDY RGSPLHLANFLYF

g13540498 42 MTTCEFEFIFLKEQVT RICNIAPLKAYFSVHK MGKILKKLSNFSFLTH

RQSLTLSPRLECSGAI SAHCNLHLLGSSNSAA SASRVAGTTGACHHAQ

LIFVFLVETGFHHVGQ DGLGLLTS

g13543287 43 MSCNPSFGGIGKGHLM REVDALDGLCSRICDQ SGVHYKVLNRRKGPAV

WGLRAQIDRKLYKQNM QKEILNTPLLTVQEGA VEDLILTEPEPEHTGK

CRVSGVVLVDGSTVYA ESVILTTGTFLRGMIV IGLETHPAGRLGDQPS

IGLAQTLEKLGFVVGR LKTGTPPRIAKESINF SILNKHIPDNPSIPFS

FTNETVWIKPEDQLPC YLTHTNPRVDEIVLKN LHLNSHVKETTRGPRY

CPSIESKVLRFPNRLH QVWLEPEGMDSDLIYP QGLSMTLPAELQEKMI

TCIRGLEKAKVIQPDG VLLLLPRMECNGAISA HHNLPLPGYGVQYDYL

DPRQITPSLETHLVQR LFFAGQINGTTGYEEA AAQGVIAGINASLRVS

RKPPFVVSRTEGYIGV LIDDLTTLGTSEPYRM FTSRVEFRLSLRPDNA

DSRLTLRGYKDAGCVS QQRYERACWMKSSLEE GISVLKSIEFLSSKWK

KLIPEASISTSRSLPV RALDVLKYEEVDMDSL AKAVPEPLKKYTKCRE

LAERLKIEATYESVLF HQLQEIKGVQQDEALQ LPKDLDYLTIRDVSLS

HEVREKLHFSRPQTIG AASRIPGVTPAAIINL LRFVKTTQRRQSAMNE

SSKTDQYLCDADRLQE REL

g13569856 44 MPFLYDISSCWTSFCF LFFSPLDGVLLCFPGW NAVARSQLTATSASQV

QAILLVSASGVAGIIG TCHHAQPIFVFLVEMG FHHVGQACLKLLNSGD

PPASASQSAGITGMSH HARPFFFFFSF

g13591868 45 MSEAENEFINWVATAA IEANCSQCWLCVELPE AAGNGLPWRIVPANIS

EWICQYQWEWDNTWFC FDFLSQSVSLSPRLEC SGTILAQCNLCLLGSS

DSPASASQVAGIIGAC RHAWLIFCIFSRDGVS PYCPG

g13591870 46 MALFLDKMGSLQKGNY SSQSGMIPGSWQHKMK LQLILKSSKAYYVLSD

AAMSLQKYGRALRYIK LALQSHDTYCCLCTNM LSEVLLFLSQYLTLCG

DIQLMLAQNANNRAAH LEEFHYQTKEDQEILH SLHRESSCQGVPQAWT

TWFTVGLCSLAHAYLS IQKRGRNIRVLIFALY LFIYFLRRSFALVAQA

GVQWCNLGSLKPPPPG FKQFSCLSLPSSWNYR HAPPCPASPPWPPKVL

GLQV

g1362993 47 RSLTLWPSLEYSGTIS AHCNLRLPGSSDSRAS ASRAAGITGVSHCARP

CMLFDPEFDLLAGVQL LPFEPPTGKALSRKD

g13631907 48 MEFRKLRGMETRPPAN TARLQPPRDLRSSSPR KQLSESSDDDYDDVDI

PTPAEDTPPPLPPKPK FRSPSDEGPGSMGDDG QLSPGVLVRCASGPPP

NSPRPGPPPSTSSPHL TAHSEPSLWNPPSREL DKPPLLPPKKEKMKRK

GCALLVKLFNGCPLRI HSTAAWTHPSTKDQHL LLGAEEGIFILNRNDQ

EATLEMLFPSRTTWVY SINNVLMSLSGKTPHL YSHSILGLLERKETRA

GNPIAHISPHRLLARK NMVSTKIQDTKGCRAC CVAEGASSGGPFLCGA

LETSVVLLQWYQPMNK FLLVRQVLFPLPTPLS VFALLTGPGSELPAVC

IGVSPGRPGKSVLFHT VRFGALSCWLGEMSTE HRGPVQVTQVEEDMVM

VLMDGSVKLVTPEGSP VRGLRTPEIPMTEAVE AVAMVGGQLQAFWKHG

VQVWALGSDQLLQELR DPTLTFRLLGSPRLEC SGTISPHCNLLLPGSS

NSPASASRVAGITGL

g13644612 49 MSMVLGGPFSKGHTAS DEYFQIFHNISFFETE SCSVAQAGVQWCNLGS

LQALPPRFTPFSCLSL PSSWDYRHPPPCPDNV FVFSVETGLHCVSQDG

LNLLTL

g13646055 50 MDCGSVGGQRTQRLPG RQRLLFLPVGLSGRPG GSETSARRCLSALSDG

LGALRPRAPAARGGVS RASPLLLLLLVPSPRL AAAAPRRQLGDWERSR

LGYAAPPAGRSSAWRC SPGVAAAAGALPQYHG PAPALVSCRRELSLSA

GSLQLERKRRDFTSSG SRKLYFDTHALVCLLE DNESHSFIQAGVQWHS

LGLLQPPPPGFKRSSH LILLSSWDYRHAPPHL DNFSVFLLETGFHHVG

QAGLKLLTSSDPPTLA S

g13646423 51 MNFFFKTEFLSVTQAG MQWHNFSSLQPLPPGF KQFSCLSLLSSWDYRH

TPPCPANFCIFSRGGV SPCWSGWSRTPDFMIH PPRPPKVLRLQK

g13648611 52 MPLAAYCYLRVVGKGS YGEVTLVKHRRDGKQY VIKKLNLRNASSRERR

AAEQEAQLLSQLKHPN IVTYKESWEGGDGLLY IVMGFCEGGDLYRKLK

EQKGQLLPENQVVEWF VQIAMALQYLHEKHIL HRDLKTQNVFLTRTNI

IKVGDLGIARVLENHC DMASTLIGTPYYMSPE LFSNKPYNYKSDVWAL

GCCVYEMATLKHAFNA KDMNSLVYRIIEGKLP PMPRDYSPELAELIRT

MLSKRPEERPSVRSIL RQPYIKRQISFFLEAT KIKTSKNNIKNGDSQS

KPFATVVSGEAESNHE VIHPQPLSSEGSQTYI MGEGKCLSQEKPRASG

LLKSPASLKAHTCKQD LSNTTELATISSVNID ILPAKGRDSVSDGFVQ

ENQPRYLDASNELGGI CSISQVEEEMLQDNTK SSAQPENLIPMWSSDI

VTGEKNEPVKPLQPLI KEQKPKDQSLALSPKL ECSGTILAHSNLRLLG

SSDSPASASRVAGITG VCHHAQDQVAGECIIE KQGRIHPDLQPHNSGS

EPSLSRQRRQKRREQT EHRGEKRQVRRDLFAF QESPPRFLPSHPIVGK

VDVTSTQKEAENQRRV VTGSVSSSRSSEMSSS KDRPLSARERRRLKQS

QEEMSSSGPSVRKASL SVAGPGKPQEEDQPLP ARRLSSDCSVTQERKQ

IHCLSEDELSSSTSST DKSDGDYGEGKGQTNE INALVQLMTQTLKLDS

KESCEDVPVANPVSEF KLHRKYRDTLILHGKV AEEAEEIHFKELPSAI

MPGSEKIRRLVEVLRT DVIRGLGVQLLEQVYD LLEEEDEFDREVRLRE

HMGEKYTTYSVKARQL KFFEENMNF

g13651342 53 MFISFGRLIFSFFLTW SLSLSPRLECSGTILA HCNPTSQVQAILPASA

SRVAGITGMHHHTCLI FVLLVKMGFCHVGHAG LELVT

g13652010 54 MESGQPSLSFYFLFIY FFEIGSHFVTQAGVQW HNLDSLQLSLASAPQV

AGTTGACHHARLIFGV FCRDWVLPC

g13653409 55 MLLVDADQPEPMRSGA RELALFLTPEPGAEAK EVEETIEGMLLRLEEF

CSLADLIRSDTSQILE ENIPVLKAKLTEMRGI YAKVDRLEAFVKMVGH

HVAFLEADVLQAERDH GAFPQALRRWLGSAGL PSFRNVECSGTIPARC

NLRLPGSSDSPASASQ VAGIPEVTCTGARDVR AAHTV

g13699916 56 MSRGNENRLTHRRQTV LREKGRRLANRGPAYM FNDHSTSLSIEEERFL

DAAEYGNIPVVRKMLE ECLSLNVNCVDYMGQN ALQLAVANEHLEITEL

LLKKENLSRVGDALLL AISKGYVRIVEAILNH PAFAEGKRLATSPSQS

ELQQDDFYAYDEDGTR FSHDVTPIILAAHCQE YEIVHTLLRKGARIER

PHDYFCKCTECSQKQK HDSFSHSRSRINAYKG LASPAYLSLSSEDPVM

TALELSNELAVLANIE KEFKNDYRKLSMQCKD FVVGLLDLCRNTEEVE

AILNGDAETRQPGDLA RPNLSRLKLAIKYEVK KFVAHPNCQQQLLSIW

YENLSGLRQQTMAVKF LVVLAVAIGLPFLALI YWCAPCSKMGKILRGP

FMKFVAHAASFTIFLG LLVMNAADRFEGTKLL PNETSTDNARQLFRMK

TSCFSWMEMLIISWVI GMIWAECKEIWTQGPK EYLFELWNMLDFGMLA

IFAASFIARFMAFWHA SKAQSIIDANDTLKDL TKVTLGDNVKYYNLAR

IKWDPTDPQIISEGLY AIAVVLSFSRIAYILP ANESFGPLQISLGRTV

KDIFKFMVIFIMVFVA FMIGMFNLYSYYIGAK QNEAFTTVEESFKTLF

WAIFGLSEVKSVVINY NHKFIENIGYVLYGVY NVTMVIVLLNMLIAMI

NSSFQEIEDDADVEWK FARAKLWFSYFEEGRT LPVPFNLVPSPKSLLY

LLLKFKKWMSELIQGH KKGFQEDAEMNKRNEE KKFGILGSHEDLSKFS

LDRNQLAHNKQSSTRS SEDFHLNSFSNPPRQY QKIMKRLIKRYVLQAQ

IDKESDEVNEGELKEI KQDISSLRYELLEEKS QNTEDLAELIRKLGER

LSLESKQEESRR

g13702149 57 MSRGNENRLTHRRQTV LREKGRRLANRGPAYM FNDHSTSLSIEEERFL

DAAEYGNIPVVRKMLE ECLSLNVNCVDYMGQN ALQLAVANEHLEITEL

LLKKENLSRVGDALLL AISKGYVRIVEAILNH PAFAEGKRLATSPSQS

ELQQDDFYAYDEDGTR FSHDVTPIILAAHCQE YEIVHTLLRKGARIER

PHDYFCKCTECSQKQK HDSFSHSRSRINAYKG LASPAYLSLSSEDPVM

TALELSNELAVLANIE KEFKNDYRKLSMQCKD FVVGLLDLCRNTEEVE

AILNGDAETRQPGDLA RPNLSRLKLAIKYEVK KFVAHPNCQQQLLSIW

YENLSGLRQQTMAVKF LVVLAVAIGLPFLALI YWCAPCSKMGKILRGP

FMKFVAHAASFTIFLG LLVMNAADRFEGTKLL PNETSTDNARQLFRMK

TSCFSWMEMLIISWVI GMIWAECKEIWTQGPK EYLFELWNMLDFGMLA

IFAASFIARFMAFWHA SKAQSIIDANDTLKDL TKVTLGDNVKYYNLAR

IKWDPTDPQIISEGLY AIAVVLSFSRIAYILP ANESFGPLQISLGRTV

KDIFKFMVIFIMVFVA FMIGMFNLYSYYIGAK QNEAFTTVEESFKTLF

WAIFGLSEVRSVVINY NHKFIENIGYVLYGVY NVTMVIVLLNMLIAMI

NSSFQEIERNEEKKFG ILGSHEDLSKFSLDRN QLAHNKQSSTRSSEDF

HLNSFSNPPRQYQKIM KRLIKRYVLQAQIDKE SDEVNEGELKEIKQDI

SSLRYELLEEKSQNTE DLAELIRRLGERLSLE SKQEESRR

g14043238 58 MESRSVAQAGVQWPDL GSLQPLPPRFKRFFCL SLQSSWDYRHAPPRPA

NFVFLVETGFCHVSQA GLELLTSSDPPPRPPK VLR

g14192931 59 MISVHCNLCLPGSSDP PASASQVAGITGVRHC MASGAVLNKVRRHQCS

GDLEVRGSHGSLGEAP WGKSVPGRGTASRKGP GAGVIGNSKEASTGRA

QWSAPVIPATQEAKAG GLLEPRSLISAWATYQ DLISINKLKEKRG

g14198309 60 MTRSLFKGNFWSADIL STIGYDNIIQHLNNGR KNCKEFEDFLKERAAI

EERYGKDLLNLSRKKP CGQSEINTLKRALEVF KQQVDNVAQCHIQLAQ

SLREEARKMEEFREKQ KLQRKKMESHSVTQAG AQWHDLGSLQALPPGF

MPFSCLSLPSSWNYRL PPPPRLAEPRNQDHGV A

g14249973 61 MESHSVTQAGVQWRDL GSLQPLPPGFKQFSHL SLPSSWDYRRVPPYLG

NFCIFSGEGVSPCWPG WS

g16226025 62 MGSLSTANVEFCLDVF KELNSNNIGDNIFFSS LSLLYALSMVLLGARG

ETAEQLEKVLHFSHTV DSLKPGFKDSPKCSQA GRIHSEFGVEFSQINQ

PDSNCTLSIANRLYGT KTMAFHQQYLSCSEKW YQARLQTVDFEQSTEE

TRKTINAWVENKTNGK VANLFGKSTIDPSSVM VLVNTIYFKGQRQNKF

QVRETVKSPFQLSEGK NVTVEMMYQIGTFKLA FVKEPQMQVLELPYVN

NKLSMIILLPVGIANL KQIEKQLNSGTFHEWT SSSNMMEREVEVHLPR

FKLEIKYELNSLLKPL GVTDLFNQVKADLSGM SPTKGLYLSKAIHKSY

LDVSEEGTEAAAATGD SIAVKSLPMRAQFKAN HPFLFFIRHTHTNTIL

FCGKLASP

g16517174 63 MAQFYYKRNVNAPYRD RIPLRIVRAESELSPS EKAYLNAVEKGDYASV

KKSLEEAEIYFKININ CIDPLGRTALLIAIEN ENLELIELLLSFNVYV

GDALLHAIRKEVVGAV ELLLNHKKPSGEKQVP PILLDKQFSEFTPDIT

PIILAAHTNNYEIIKL LVQKGVSVPRPHEVRC NCVECVSSSDVDSLRH

SRSRLNIYKALASPSL IALSSEDPFLTAFQLS WELQELSKVENEFKSE

YEELSRQCKQFAKDLL DQTRSSRELEIILNYR DDNSLIEEQSGNDLAR

LKLAIKYRQKEFVAQP NCQQLLASRWYDEFPG WRRRHWAVKMVTCFII

GLLFPVFSVCYLIAPK SPLGLFIRKPFIKFIC HTASYLTFLFLLLLAS

QHIDRSDLNRQGPPPT IVEWMILPWVLGFIWG EIKQMWDGGLQDYIHD

WWNLMDFVMNSLYLAT ISLKIVAFVKYSALNP RESWDMWHPTLVAEAL

FAIANIFSSLRLISLF TANSHLGPLQISLGRM LLDILKFLFIYCLVLL

AFANGLNQLYFYYEET KGLTCKGIRCEKQNNA FSTLFETLQSLFWSIF

GLINLYVTNVKAQHEF TEFVGATMFGTYNVIS LVVLLNMLIAMMNNSY

QLIADHADIEWKFART KLWMSYFEEGGTLPTP FNVIPSPKSLWYLIKW

IWTHLCKKKMRRKPES FGTIGVRTQHRRAADN LRRHHQYQEVMRNLVK

RYVAAMIRDAKTEEGL TEENFKELKQDISSFR FEVLGLLRGSKLSTIQ

SANASKESSNSADSDE KSDSEGNSKDKKKNFS LFDLTTLIHPRSAAIA

SERHNISNGSALVVQE PPREKQRKVNFVTDIK NFGLFHRRSKQNAAEQ

NANQIFSVSEEVARQQ AAGPLERNIQLESRGL ASRGDLSIPGLSEQCV

LYDHRERNTDTLGLQV GKRVCPFKSEKVVVED TVPIIPKEKHAKEEDS

SIDYDLNLPDTVTHED YVTTRL

g16517176 64 MAQFYYKRNVNAPYRD RIPLRIVRAESELSPS EKAYLNAVEKGDYASV

KKSLEEAEIYFKININ CIDPLGRTALLIAIEN ENLELIELLLSFNVYV

GDALLHAIRKEVVGAV ELLLNHKKPSGEKQVP PILLDKQFSEFTPDIT

PIILAAHTNNYEIIKL LVQKGVSVPRPHEVRC NCVECVSSSDVDSLRH

SRSRLNIYKALASPSL IALSSEDPFLTAFQLS WELQELSKVENEFKSE

YEELSRQCKQFAKDLL DQTRSSRELEIILNYR DDNSLIEEQSGNDLAR

LKLAIKYRQKEASYGE KLNRCGMADFRTTSMI GGI

g16758330 65 MSQSPGFVTRRGGSPK AAPGAGARRNESQDYL LMDELGDDGYPQLQQP

PYGYYPSFRGNENRLT HRRQTVLREKGRRLAN RGPAYMFNDHSTSLSI

EEERFLDAAEYGNIPV VRKMLEECLSLNVNCV DYMGQNALQLAVANEH

LEITELLLKKENLSRV GDALLLAISKGYVRIV EAILNHPAFAEGKRLA

TSPSQSELQQDDFYAY DEDGTRFSHDVTPIIL AAHCQEYEIVHTLLRK

GARIERPHDYFCKCTE CSQKQKHDSFSHSRSR INAYKGLASPAYLSLS

SEDPVMTALELSNELA VLANIEKEFKNDYRKL SMQCKDFVVGLLDLCR

NTEEVEAILNGDAETR QPGDLARPNLSRLKLA IKYEVKKFVAHPNCQQ

QLLSIWYENLSGLRQQ TMAVKFLVVLAVAIGL PFLALIYWCAPCSKMG

KILRGPFMKFVAHAAS FTIFLGLLVMNAADRF EGTKLLPNETSTDNAR

QLFRMKTSCFSWMEML IISWVIGMIWAECKEI WTQGPKEYLFELWNML

DFGMLAIFAASFIARF MAFWHASKAQSIIDAN DTLKDLTKVTLGDNVK

YYNLARIKWDPTDPQI ISEGLYAIAVVLSFSR IAYILPANESFGPLQI

SLGRTVKDIFKFMVIF IMVFVAFMIGMFNLYS YYIGAKQNEAFTTVEE

SFKTLFWAIFGLSEVK SVVINYNHKFIENIGY VLYGVYNVTMVIVLLN

MLIAMINSSFQEIEDD ADVEWKFARAKLWFSY FEEGRTLPVPFNLVPS

PKSLLYLLLKFKKWMS ELIQGHKKGFQEDAEM NKRNEEKKFGILGSHE

DLSKFSLDRNQLAHNK QSSTRSSEDFHLNSFS NPPRQYQKIMKRLIKR

YVLQAQIDKESDEVNE GELKEIKQDISSLRYE LLEEKSQNTEDLAELI

RKLGERLSLESKQEES RR

g1710216 66 MGHPRAIQPSVFFSPY DVHFLLYPIRCPYLKI GRFHIKLKGLHFLFSF

LFFFFETQSHSVTRLE CSGTISAHCNLCLPGS SNSPASASRVAGTAGT

CRRAQLIFVFLAEMGF HHVGRDGLDLNLVIHP PRSPKALGLQA

g17978303 67 MGSLSTANVEFCLDVF KELNSNNIGDNIFFSS LSLLYALSMVLLGARG

ETAEQLEKVLHFSHTV DSLKPGFKDSPKCSQA GRIHSEFGVEFSQINQ

PDSNCTLSIANRLYGT KTMAFHQQYLSCSEKW YQARLQTVDFEQSTEE

TRKMINAWVENKTNGK VANLFGKSTIDPSSVM VLVNTIYFKGQRQNKF

QVRETVKSPFQLSEGK NVTVEMMYQIGTFKLA FVKEPQMQVLELPYVN

NKLSMIILLPVGIANL KQIEKQLNSGTFHEWT SSSNMMEREVEVHLPR

FKLEIKYELNSLLKPL GVTDLFNQVKADLSGM SPTKGLYLSKAIHKSY

LDVSEEGTEAAAATGD SIAVKSLPMRAQFKAN HPFLFFIRHTHTNTIL

FCGKLASP

g18376629 68 MLRNSTFKNMQRRHTT LREKGRRQAIRGPAYM FNEKGTSLTPEEERFL

DSAEYGNIPVVRKMLE ESKTLNFNCVDYMGQN ALQLAVGNEHLEVTEL

LLKKENLARVGDALPL AISKGYVRIVEAILNH PAFAQGQRLTLSPLEQ

ELRDDDFYAYDEDGTR FSHDITPIILAAHCQE YEIVHILLLKGARIER

PHDYFCKCNECTEKQR KDSFSHSRSRMNAYKG LASAAYLSLSSEDPVL

TALELSNELARLANIE TEFKNDYRKLSMQCKD FVVGVLDLCRDTEEVE

AILNGDVNFQVWSDHH RPSLSRIKLAIKYEVK KFVAHPNCQQQLLTMW

YENLSGLR(QQSIAVKF LAVFGVSI)GLPFLAIA YWIAPCSKLGRTLRSP

FMKFVAHAVSFTIFLG LLVVNASDRFEGVKTL PNETFTDYPKQIFRVK

TTQFSWTEMLIMKWVL GMIWSECKEIWEEGPR EYVLHLWNLLDFGMLS

IFVASFTARFMAFLKA TEAQLYVDQHVQDDTL HNVSLPPEVAYFTYAR

DKWWPSDPQIISEGLY AIAVVLSFSRIAYILP ANESFGPLQISLGRTV

KDIFKFMVIFIMVFVA FMIGMFNLYSYYRGAK YNPAFTTVEESFKTLF

WSIFGLSEVISVVLKY DHKFIENIGYVLYGVY NVTMVVVLLNMLIAMI

NNSYQEIEEDADVEWK FARAKLWLSYFDEGRT LPAPFNLVPSPKSFYY

LIMRIKMCLIKLCKSK AKSCENDLEMGMLNSK FKKTRYQAGMRNSENL

TANNTLSKPTRYQKIM KRLIKRYVLKAQVDRE NDEVNEGELKEIKQDI

SSLRYELLEEKSQATG ELADLIQQLSEKFGKN LNKDHLRVNKGKDI

g1843388 69 MKVRLLRQLSAAAKVK APSGLQGPPQAHQFIS LLLEEYGALCQAARSI

STFLGTLENEHLKKFQ VTWELHNKHLFENLVF SEPLLQSNLPALVSQI

RLGTTTHDTCSEDTYS TLLQRYQRSEEELRRV AEEWLECQKRIDAYVD

EQMTMKTKQRMLTEDW ELFKQRRFIEEQLTNK KAVTGENNFTDTMRHV

LSSRLSMPDCPNCNYR RRCACDDCSLSHILTC GIMDPPVTDDIHIHQL

PLQVDPAPDYLAERSP PSVSSASSGSGSSSPI TIQQHPRLILTDSGSA

PTFCSDDEDVAPLSAK FADIYPLSNYDDTEVV ANMNGIHSELNGGGEN

MALKDESPQISSTSSS SSEADDEEADGESSGE PPGAPKEDGVLGSRSP

RTEESKADSPPPSYPT QQAEQAPNTCECHVCK QEASGLTPSAMTAGAL

PPGHQFLSPEKPTHPA LHLYPHIHGHVPLHTV PHLPRPLIHPTLYATP

PFTHSKALPPAPVQNH TNKHQVFNASLQDHIY PSCFGNTPEWNSSKFI

SLWGSEVMNDKNWNPG TFLPDTISGSEILGPT LSETRPEALPPPSSNE

TPAVSDSKEKKNAAKK KCLYNFQDAFMEANKV VMATSSATSSVSCTAT

TVQSSNSQFRVSSKRP PSVGDVFHGISKEDHR HSAPAAPRNSPTGLAP

LPALSPAALSPAALSP ASTPHLANLAAPSFPK TATTTPGFVDTRKSFC

PAPLPPATDGSISAPP SVCSDPDCEGHRCENG VYDPQQDDGDESADED

SCSEHSSSTSTSTNQK EGKYCDCCYCEFFGHG GPPAAPTSRNYAEMRE

KLRLRLTKRKEEQPKK MDQISERESVVDHRRV EDLLQFINSSETKPVS

STRAAKRARHKQRKLE EKARLEAEARAREHLH LQEEQRRREEEEDEEE

EEDRFKEEFQRLQELQ KLRAVKKKKKERPSKD CPKLDMLTRNFQAATE

SVPNSGNIHNGSLEQT EEPETSSHSPSRHMNH SEPRPGLGADGDAADP

VDTRDSKFLLPKEVNG KQHEPLSFFFDIMQHH KEGNGKQKLRQTSKAS

SEPARRPTEPPKATEG QSKPRAQTESKAKVVD LMSITEQKREERKVNS

NNNNKKQLNHIKDEKS NPTPMEPTSPGEHQQN SKLVLAESPQPKGKNK

KNKKKKGDRVNNSIDG VSLLLPSLGYNGAILA HCNLRLPGSSDCAASA

SQVVGITDDVFLPKDI DLDSVDMDETEREVEY FKRFCLDSARQTRQRL

SINWSNFSLKKATFAA H

g20140144 70 MGSLSTANVEFCLDVF KELNSNNIGDNIFFSS LSLLYALSMVLLGARG

ETAEQLEKVLHFSHTV DSLKPGFKDSPKCSQA GRIHSEFGVEFSQINQ

PDSNCTLSIANRLYGT KTMAFHQQYLSCSEKW YQARLQTVDFEQSTEE

TRKMINAWVENKTNGK VANLFGKSTIDPSSVM VLVNIIYFKGQRQNKF

QVRETVKSPFQLSEGK NVTVEMMYQIGTFKLA FVKEPQMQVLELPYVN

NKLSMIILLPVGIANL KQIEKQLNSGTFHEWT SSSNMMEREVEVHLPR

FKLEIKYELNSLLKPL GVTDLFNQVKADLSGM SPTKGLYLSKAIHKSY

LDVSEEGTEAAAATGD SIAVKSLPMRAQFKAN HPFLFFIRHTHTNTIL

FCGKLASP

g20476660 71 MMAALYPSTDLSGASS SSLPSSPSSSSPNEVM ALKDVREVKEENTLNE

KLFLLACDKGDYYMVK KILEENSSGDLNINCV DVLGRNAVTITIENEN

LDILQLLLDYGCQSAD ALLVAIDSEVVGAVDI LLNHRPKRSSRPTIVK

LMERIQNPEYSTTMDV APVILAAHRNNYEILT MLLKQDVSLPKPHAVG

CECTLCSAKNKKDSLR HSRFRLDIYRCLASPA LIMLTEEDPILRAFEL

SADLKELSLVEVEFRN DYEELARQCKMFAKDL LAQARNSRELEVILNH

TSSDEPLDKRGLLEER MNLSRLKLAIKYNQKE FVSQSNCQQFLNTVWF

GQMSGYRRKPTCKKIM TVLTVGIFWPVLSLCY LIAPKSQFGRIIHTPF

MKFIIHGASYFTFLLL LNLYSLVYNEDKKNTM GPALERIDYLLILWII

GMIWSDIKRLWYEGLE DFLEESRNQLSFVMNS LYLATFALKVVAHNKF

HDFADRKDWDAFHPTL VAEGLFAFANVLSYLR LFFMYTTSSILGPLQI

SMGQMLQDFGKFLGMF LLVLFSFTIGLTQLYD KGYTSKEQKDCVGIFC

EQQSNDTFHSFIGTCF ALFWYIFSLAHVAIFV TRFSYGEELQSFVGAV

IVGTYNVVVVIVLTKL LVAMLHKSFQLIANHE DKEWKFARAKLWLSYF

DDKCTLPPPFNIIPSP KTICYMISSLSKWICS HTSKGKVKRQNSLKEW

RNLKQKRDENYQKVWC CLVHRYLTSMRQKMQS TDQATVENLNELRQDL

SKFRNEIRDLLGFRTS KYAMFYPRN

g20546044 72 MAQFYYKRNVNAPYRD RIPLRIVRAESELSPS EKAYLNAVEKGDYASV

KKSLEEAEIYFKININ CIDPLGRTALLIAIEN ENLELIELLLSFNVYV

GDALLHAIRKEVVGAV ELLLNHKKPSGEKQVP PILLDKQFSEFTPDIT

PIILAAHTNNYEIIKL LVQKGVSVPRPHEVRC NCVECVSSSDVDSLRH

SRSRLNIYKALASPSL IALSSEDPFLTAFQLS WELQELSKVENEFKSE

YEELSRQCKQFAKDLL DQTRSSRELEIILNYR DDNSLIEEQSGNDLAR

LKLAIKYRQKEFVAQP NCQQLLASRWYDEFPG WRRRHWAVKMVTCFII

GLLFPVFSVCYLIAPK SPLGLFIRKPFIKFIC HTASYLTFLFLLLLAS

QHIDRSDLNRQGPPPT IVEWMILPWVLGFIWG EIKQMWDGGLQDYIHD

WWNLMDFVMNSLYLAT ISLKIVAFVKYSALNP RESWDMWHPTLVAEAL

FAIANIFSSLRLISLF TANSHLGPLQISLGRM LLDILKFLFIYCLVLL

AFANGLNQLYFYYEET KGLTCKGIRCEKQNNA FSTLFETLQSLFWSIF

GLINLYVTNVKAQHEF TEFVGATMFGTYNVIS LVVLLNMLIAMMNNSY

QLIADHADIEWKFART KLWMSYFEEGGTLPTP FNVIPSPKSLWYLIKW

IWTHLCKKKMRRKPES FGTIGVRTQHRRAADN LRRHHQYQVIMRNLVK

RYVAAMIRDAKTEEGL TEENFKELKQDISSFR FEVLGLLRGSKLSTIQ

SANASKESSNSADSDE KSDSEGNSKDKKKNFS LFDLTTLIHPRSAAIA

SERHNISNGSALVVQE PPREKQRKVNFVTDIK NFGLFHRRSKQNAAEQ

NANQIFSVSEEVARQQ AAGPLERNIQLESRGL ASRGDLSIPGLSEQCV

LVDHRERNTDTLGLQV GKRVCPFKSEKVVVED TVPIIPKEKHAKEEDS

SIDYDLNLPDTVTHED YVTTRL

g20881287 73 MSQSPRFVTRRGGSLK AAPGAGTRRNESQDYL LMDELGDDGYPQLPLP

PYGYYPSFRGNENRLT HRRQTILREKGRRLAN RGPAYMFNDHSTSLSI

EEERFLDAAEYGNIPV VRKMLEECHSLNVNCV DYMGQNALQLAVANEH

LEITELLLKKENLSRV GDALLLAISKGYVRIV EAILNHPAFAEGKRLA

TSPSQSELQQDDFYAY DEDGTRFSHDVTPIIL AAHCQEYEIVHTLLRK

GARIERPHDYFCKCTE CSQKQKHDSFSHSRSR INAYKGLASPAYLSLS

SEDPVMTALELSNELA VLANIEKEFKNDYRKL SMQCKDFVVGLLDLCR

NTEEVEAILNGDAETR QPGDFGRPNLSRLKLA IKYEVKKFVAHPNCQQ

QLLSIWYENLSGLRQQ TMAVKFLVVLAVAIGL PFLALIYWCAPCSKMG

KILRGPFMKFVAHAAS FTIFLGLLVMNAADRF EGTKLLPNETSTDNAR

QLFRMKTSCFSWMEML IISWVIGMIWAECKEI WTQGPKEYLFELWNML

DFGMLAIFAASFIARF MAFWHASKAQSIIDAN DTLKDLTKVTLGDNVK

YYNLARIKWDPTDPQI ISEGLYAIAVVLSFSR IAYILPANESFGPLQI

SLGRTVKDIFKFMVIF IMVFVAFMIGMFNLYS YYIGAKQNEAFTTVEE

SFKTLFWAIFGLSEVK SVVINYNHKFIENIGY VLYGVYNVTMVIVLLN

MLIAMINSSFQEIEDD ADVEWKFARAKLWFSY FEEGRTLPVPFNLVPS

PKSLLYLLLKFKKWMC ELIQGQKQGFQEDAEM NKRNEEKKFGISGSHE

DLSKFSLDKNQLAHNK QSSTRSSEDYHLNSFS NPPRQYQKIMKRLIKR

YVLQAQIDKESDEVNE GELKEIKQDISSLRYE LLEEKSQNTEDLAELI

RKLGERLSLEPKLEES RR

g2105420 74 PSGLPLLPVLFALGGL LLLSNASCVGGVLWQR RLRRLAEALNFPPHLH

PGRSEEDRVRNEYEES QWTGERDTQSSTVSTT EAEPYYRSLRDFSPQL

PPTQEEVSYSRGFTGE DEDMAFPGHLYDEVER TYPPSGAWGPLYDEVQ

MGPWDLHWPEDTYQDP RGIYDQVAGDLDTLEP DSLPFELRGHLVWGFN

HVSQAGLKLLASSDPP ASASQSAEITESHSVV QVGVQWRYFGSLHPLP

PGSRDSLASASRIAGI TAPWEAEVSRSPQGTQ DSPVTRSGPPSRGWQS

LSFDGGAFHLKGTGEL TRALLVLRLCAWPPLV THGLLLQAWSRRLLGS

RLSGAFLRASVYGQFV AGETAEEVKGCVQQLR TLSLRPLLAVPTEEEP

DSAAKRMRLHHVGQAG LELLTPAASGSVAQAG VQWRQSSDRGGGNQAA

ASRSSLLQEAAFSPPC GRLQLPAQPASRHGAR GRGSMKAKSLTSRHLL

ASQGQETIIKTKVRIP ALWKAEPGQHSKTPSQ QNKSQYVTTLWEADVG

RSLENLQVSCLNAEQN QHLRASLSRLHRVTPP AGTSTSGPPSAACIGW

HSRLHRVAQYARAQHV RLLVDAEYTSLNPALS LLVAALAVRWNSPGEG

GPWVWNTYQACLKDTF ERLGRDAEAAHRAGLA FGVKLVRGAYLDKERA

VAQLHGMEDPTQPDYE ATSELNRASPFSYSRC LELMLTHVARHGPMCH

LMVASHNEESVRQATK RMWELGIPLDGTVCFG QLLGMCDHVSLALGQA

GYVVYKSIPYGSLEEV IPYLIRRAQENRSVLQ GARREQELLSQELWRR

LLPGCRRIPH

g2119643 75 SCSVTLAGVQWRDLGL LQPLPPKFKRFSCLSF PSSWDYR

g2119644 76 EMEFNCESCSVTLAGV QWRDLGLLQPLPPKFK RFSCLSFPSSWDYR

g2136328 77 MCPGIPGPRAEAAVGT THPFSSPGAWLGSGSG SGPVGAPPPSPGLPPS

WAAMMAALYPSTDLSG ASSSSLPSSPSSSSPN EVMALKDVREVKEENT

LNEKLFLLACDKGDYY MVKKILEENSSGDLNI NCVDVLGRNAVTITIE

NENLDILQLLLDYGCQ KLMERIQNPEYSTTMD VAPVILAAHRNNYEIL

TMLLKQDVSLPKPHAV GCECTLCSAKNKKDSL RHSRFRLDIYRCLASP

ALIMLTEEDPILRAFE LSADLKELSLVEVEFR NDYEELARQCKMFAKD

LLAQARNSRELEVILN HTSSDEPLDKRGLLEE RMNLSRLKLAIKYNQK

EFVSQSNCQQFLNTVW FGQMSGYRRKPTCKKI MTVLTVGIFWPVLSLC

YLIAPKSQFGRIIHTP FMKFIIHGASYFTFLL LLNLYSLVYNEDKKNT

MGPALERIDYLLILWI IGMIWSDIKRLWYEGL EDFLEESRNQLSFVMN

SLYLATFALKVVAHNK FHDFADRKDWDAFHPT LVAEGLFAFANVLSYL

RLFFMYTTSSILGPLQ ISMGQMLQDFGKFLGM FLLVLFSFTIGLTQLY

DKGYTSKEQKDCVGIF CEQQSNDTFHSFIGTC FALFWYIFSLAHVAIF

VTRFSYGEELQSFVGA VIVGTYNVVVVIVLTK LLVAMLHKSFQLIANH

EDKEWKFARAKLWLSY FDDKCTLPPPFNIIPS PKTICYMISSLSKWIC

SHTSKGKVKRQNSLKE WRNLKQKRDENYQKVM CCLVHRYLTSMRQKMQ

STDQATVENLNELRQD LSKFRNEIRDLLGFRT SKYAMFYPRN

g3766191 78 MSRGNENRLTHRRQTI LREKGRRLANRGPAYM FNDHSTSLSIEEERFL

DAAEYGNIPVVRKMLE ECHSLNVNCVDYMGQD ALQLAVANEHLEITEL

LLKKENLSRVGDALLL AISKGYVRIVEAILNH PAFAEGKRLATSPSQS

ELQQDDFYAYDEDGTR FSHDVTPIILAAHCQE YEIVHTLLRKGARIER

PHDYFCKCTECSQKQK HDSFSHSRSRINAYKG LASPAYLSLSSEDPVM

TALELSNELAVLANIE KEFKNDYRKLSMQCKD FVVGLLDLCRNTEEVE

AILNGDAETRQPGDFG RPNLSRLKLAIKYEVK KFVAHPNCQQQLLSIW

YENLSGLRQQTMAVKF LVVLAVAIGLPFLALI YWCAPCSKMGKILRGP

FMKFVAHAASFTIFLG LLVMNAADRFEGTKLL PNETSTDNARQLFRMK

TSCFSWMEMLIISWVI GMIWAECKEIWTQGPK EYLFELWNMLDFGMLA

IFAASFIARFMAFWHA SKAQSIIDANDTLKDL TKVTLGDNVKYYNLAR

IKWDPTDPQIISEGLY AIAVVLSFSRIAYILP ANESFGPLQISLGRTV

KDIFKFMVIFIMVFVA FMIGMFNLYSYYIGAK QNEAFTTVEESFKTLF

WAIFGLSEVKSVVINY NHKFIENIGYVLYGVY NVTMVIVLLNMLIAMI

NSSFQEIEDDADVEWK FARAKLWFSYFEEGRT LPVPFNLVPSPKSLLY

LLLKFKKWMCELIQGQ KQGFQEDAEMNKRNEE KKFGISGSHEDLSKFS

LDKNQLAHNKQSSTRS SEDYHLNSFSNPPRQY QKIMKRLIKRYVLQAQ

IDKESDEVNEGELKEI KQDISSLRYELLEEKS QNTEDLAELIRKLGER

LSLEPKLEESRR

g403460 79 DRLSLLSPRLECNGMI LAHCKLRLPGFKRFSC LSLPSSWDYRHVPPRQ

VHFVFSVETGFHRAGQ AGLELLTSSVPPTSAF PKCWDYRRDDQAWPTL

SSFRGLNKFAFLPKFF AHPISQFQRVECNVGC PILLAMKYLAYSSLPG

ADTMLYFYFYEQEASL AVCNICRQKFHWVLYQ ISHLYRGVIVDNFLLH

PDGRFTWTIFFLSWVK QNSLYDFFFGTESRSV ALLPRLECSGAMSTLH

TVLRPAYSHIYHPDVK EKTHFLGNVFNKRKLQ KKILKTPNPLCALHSA

PSPSLPPFLRCTGRLP FYLGLDDFLFVAGALM FLPVSFLNPHTLTWPP

QCCTRSDCNPLRGQRE ISALSHSLPTGLSMPL

g4200234 80 MAALYACTKCHQRFPF EALSQGQQLCKECRIA HPVVKCTYCRTEYQQE

RLECNGTISAHCNLHL PGSSDSPASSSRVAGI TGIKTNTICKKCAQNV

QLYGTPKPCQYCNIIA AFIGNKCQRCTNSEKK YGPPYSCEQCKQQCAF

DRKDDRKKVDGKLLCW LCTLSYKRVLQKTKEQ RKHLSSSSRAGHQEKE

QYSRLSGGGHYNSQKT LSTSSIQNEIPKKKSK FESITTNGDSFSPDLA

LDSPGTDHFVIIAQLK EEVATLKKMLHQKDQM ILEKEKKITELKADFQ

YQESQMRAKMNQMEKT HKEVTEQLQAKNRELL KQAAALSKSKKSEKSG

AITSP

g4200238 81 MAALYACTKCHQRFPF EALSQGQQLCKECRIA HPVVKCTYCRTEYQQE

RLECNGTISAHCNLHL PGSSDSPASSSRVAGI TGIKTNTICKKCAQNV

QLYGTPKPCQYCNIIA AFIGNKCQRCTNSEKK YGPPYSCEQCKQQCAF

DRKDDRKKVDGKLLCW LCTLSYKRVLQKTKEQ RKHLSSSSRAGHQEKE

QYSRLSGGGHYNSFSP DLALDSPGTDHFVIIA QLKEEVATLKKMLHQK

DQMILEKEKKITELKA DFQYQESQMRAKMNQM EKTHKEVTEQLQAKNR

ELLKQAAALSKSKKSE KSGAITSP

g423149 82 FFFFFFETESCSVAEA GVQWCDLGSLKSPPPG SSDSPASASRVAGITG

MHHHTQLIFVFLVETG SHMQLSDSTLVITTAQ NAKITARAPRDLFFFF

FFFF

g4336401 83 LPLLPRMECRGMISAH CNLCRSGSSDSPASAS RVAGITGTCHHAQLSF

PFFLFMRW

g4336402 84 LPLLPRMECRGMISAH CNLCRSGSSDSPASAS RVAGITGTCHHAQL

g4379098 85 MDIEDEENMSSSSTDV KENRNLDNVSPKDGST PGPGEGSQLSNGGGGG

PGRKRPLEEGSNGHSK YRLKKRRKTPGPVLPK NALMQLNEIKPGLQYT

LLSQTGPVHAPLFVMS VEVNGQVFEGSGPTKK KAKLHAAEKALRSFVQ

FPNASEAHLAMGRTLS VNTDFTSDQADFPDTL FNGFETPDKAEPPFYV

GSNGDDSFSSSGDLSL SASPVPASLAQPPLPV LPPFPPPSGKNPVMIL

NELRPGLKYDFLSESG ESHAKSFVMSVVVDGQ FFEGSGRNKKLAKARA

AQSALAAIFNLHLDQT PSRQPIPSEGLQLHLP QVLADAVSRLVLGKFG

DLTDNFSSPHARRKVL AGVVMTTGTDVKDAKV ISVSTGTKCINGEYMS

DRGLALNDCHAEIISR RSLLRFLYTQLELYLN NKDDQKRSIFQKSERG

GFRLKENVQFHLYIST SPCGDARIFSPHEPIL EGSRSYTQAGVQWCNH

GSLQPRPPGLLSDPST STFQGAGTTEPADRHP NRKARGQLRTKIESGE

GTIPVRSNASIQTWDG VLQGERLLTMSCSDKI ARWNVVGIQGSLLSIF

VEPIYFSSIILGSLYH GDHLSRAMYQRISNIE DLPPLYTLNKPLLSGI

SNAEARQPGKAPNFSV NWTVGDSAIEVINATT GKDELGRASRLCKHAL

YCRWXaAACARQGSLPLT TLQDYQAQRVP

g4504601 86 MLLSQNAFIVRSLNLV LMVYISLVFGISYDSP DYTDESCTFKISLRNF

RSILSWELKNHSIVPT HYTLLYTIMSKPEDLK VVKNCANTTRSFCDLT

DEWRSTHEAYVTVLEG FSGNTTLFSCSHNFWL AIDMSFEPPEFEIVGF

TNHINVMVKFPSIVEE ELQFDLSLVIEEQSEG IVKKHKPEIKGNMSGN

FTYIIDKLIPNTNYCV SVYLEHSDEQAVIKSP LKCTLLPPGQESESAE

SAKIGGIITVFLIALV LTSTIVTLKWIGYICL RNSLPKVLRQGLTKGW

NAVAIHRCSHNALQSE TPELKQSSCLSFPSSW DYKRASLCPSD

g4507277 87 MPLAAYCYLRVVGKGS YGEVTLVKHRRDGKQY VIKKLNLRNASSRERR

AAEQEAQLLSQLKHPN IVTYKESWEGGDGLLY IVMGFCEGGDLYRKLK

EQKGQLLPENQVVEWF VQIAMALQYLHEKHIL HRDLKTQNVFLTRTNI

IKVGDLGIARVLENHC DMASTLIGTPYYMSPE LFSNKPYNYKSDVWAL

GCCVYEMATLKHAFNA KDMNSLVYRIIEGKLP AMPRDYSPELAELIRT

MLSKRPEERPSYRSIL RQPYIKRQISFFLEAT KIKTSKNNIKNGDSQS

KPFATVVSGEAESNHE VIHPQPLSSEGSQTYI MGEGKCLSQEKPRASG

LLKSPASLKAHTCKQD LSNTTELATISSVNID ILPAKGRDSVSDGFVQ

ENQPRYLDASNELGGI CSISQVEEEMLQDNTK SSAQPENLIPMWSSDI

VTGEKNEPVKPLQPLI KEQKPKDQSLALSPKL ECSGTILAHSNLRLLG

SSDSPASASRVAGITG VCHHAQDQVAGECIIE KQGRIHPDLQPHNSGS

EPSLSRQRRQKRREQT EHRGEKRQVRRDLFAF QESPPRFLPSHPIVGK

VDVTSTQKEAENQRRV VTGSVSSSRSSEMSSS KDRPLSARERRRLKQS

QEEMSSSGPSVRKASL SVAGPGKPQEEDQPLP ARRLSSDCSVTQERKQ

IHCLSEDELSSSTSST DKSDGDYGEGKGQTNE INALVQLMTQTLKLDS

KESCEDVPVANPVSEF KLHRKYRDTLILHGKV AEEAEEIHFKELPSAI

MPGSEKIRRLVEVLRT DVIRGLGVQLLEQVYD LLEEEDEFDREVRLRE

HMGEKYTTYSVKARQL KFFEENMNF

g4507685 88 MMAALYPSTDLSGASS SSLPSSPSSSSPNEVM ALKDVREVKEENTLNE

KLFLLACDKGDYYMVK KILEENSSGDLNINCV DVLGRNAVTITIENEN

LDILQLLLDYGCQKLM ERIQNPEYSTTMDVAP VILAAHRNNYEILTML

LKQDVSLPKPHAVGCE CTLCSAKNKKDSLRHS RFRLDIYRCLASPALI

MLTEEDPILRAFELSA DLKELSLVEVEFRNDY EELARQCKMFAKDLLA

QARNSRELEVILNHTS SDEPLDKRGLLEERMN LSRLKLAIKYNQKEFV

SQSNCQQFLNTVWFGQ MSGYRRKPTCKKIMTV LTVGIFWPVLSLCYLI

APKSQFGRIIHTPFMK FIIHGASYFTFLLLLN LYSLVYNEDKKNTMGP

ALERIDYLLILWIIGM IWSDIKRLWYEGLEDF LEESRNQLSFVMNSLY

LATFALKVVAHNKFHD FADRKDWDAFHPTLVA EGLFAFANVLSYLRLF

FMYTTSSILGPLQISM GQMLQDFGKFLGMFLL VLFSFTIGLTQLYDKG

YTSKEQKDCVGIFCEQ QSNDTFHSFIGTCFAL FWYIFSLAHVAIFVTR

FSYGEELQSFVGAVIV GTYNVVVVIVLTKLLV AMLHKSFQLIANHEDK

EWKFARAKLWLSYFDD KCTLPPPFNIIPSPKT ICYMISSLSKWICSHT

SKGKVKRQNSLKEWRN LKQKRDENYQKVMCCL VHRYLTSMRQKMQSTD

QATVENLNELRQDLSK FRNEIRDLLGFRTSKY AMFYPRN

g4507687 89 MEGSPSLRRMTVMREK GRRQAVRGPAFMFNDR GTSLTAEEERFLDAAE

YGNIPVVRKMLEESKT LNVNCVDYMGQNALQL AVGNEHLEVTELLLKK

ENLARIGDALLLAISK GYVRIVEAILNHPGFA ASKRLTLSPCEQELQD

DDFYAYDEDGTRFSPD ITPIILAAHCQKYEVV HMLLMKGARIERPHDY

FCKCGDCMEKQRHDSF SHSRSRINAYKGLASP AYLSLSSEDPVLTALE

LSNELAKLANIEKEFK NDYRKLSMQCKDFVVG VLDLCRDSEEVEAILN

GDLESAEPLEVHRHKA SLSRVKLAIKYEVKKF VAHPNCQQQLLTIWYE

NLSGLREQTIAIKCLV VLVVALGLPFLAIGYW IAPCSRLGKILRSPFM

KFVAHAASFIIFLGLL VFNASDRFEGITTLPN ITVTDYPKQIFRVKTT

QFTWTEMLIMVWVLGM MWSECKELWLEGPREY ILQLWNVLDFGMLSIF

IAAFTARFLAFLQATK AQQYVDSYVQESDLSE VTLPPEIQYFTYARDK

WLPSDPQIISEGLYAI AVVLSFSRIAYILPAN ESFGPLQISLGRTVKD

IFKFMVLFIMVFFAFM IGMFILYSYYLGAKVN AAFTTVEESFKTLFWS

IFGLSEVTSVVLKYDH KFIENIGYVLYGIYNV TMVVVLLNMLIAMINS

SYQEIEDDSDVEWKFA RSKLWLSYFDDGKTLP PPFSLVPSPKSFVYFI

MRIVNFPKCRRRRLQK DIEMGMGNSKSRLNLF TQSNSRVFESHSFNSI

LNQPTRYQQIMKRLIK RYVLKAQVDKENDEVN EGELKEIKQDISSLRY

ELLEDKSQATEELAIL IHKLSEKLNPSMLRCE

g4885373 90 MSETVPPAPAASAAPE KPLAGKKAKKPAKAAA ASKKKPAGPSVSELIV

QAASSSKERGGVSLAA LKKALAAAGYDVEKNN SRIKLGIKSLVSKGTL

VQTKGTGASGSFKLNK KASSVETKPGASKVAT KTKATGASKKLKKATG

ASKKSVKTPKKAKKPA ATRKSSKNPKKPKTVK PKKVAKSPAKAKAVKP

KAAKARYTKPKTAKPK KAAPKKK

g5730102 91 MSQSPAFGPRRGSSPR GAAGAAARRNESQDYL LMDSELGEDGCPQAPL

PCYGYYPCFRGSDNRL AHRRQTVLREKGRRLA NRGPAYMFSDRSTSLS

IEEERFLDAAEYGNIP VVRKMLEECHSLNVNC VDYMGQNALQLAVANE

HLEITELLLKKENLSR VGDALLLAISKGYVRI VEAILSHPAFAEGKRL

ATSPSQSELQQDDFYA YDEDGTRFSHDVTPII LAAHCQEYEIVHTLLR

KGARIERPHDYFCKCN DCNQKQKHDSFSHSRS RINAYKGLASPAYLSL

SSEDPVMTALELSNEL AVLANIEKEFKNDYKK LSMQCKDFVVGLLDLC

RNTEEVEAILNGDVET LQSGDHGRPNLSRLKL AIKYEVKKFVAHPNCQ

QQLLSIWYENLSGLRQ QTMAVKFLVVLAVAIG LPFLALIYWFAPCSKM

GKIMRGPFMKFVAHAA SFTIFLGLLVMNAADR FEGTKLLPNETSTDNA

KQLFRMKTSCFSWMEM LIISWVIGMIWAECKE IWTQGPKEYLFELWNM

LDFGMLAIFAASFIAR FMAFWHASKAQSIIDA NDTLKDLTKVTLGDNV

KYYNLARIKWDPSDPQ IISEGLYAIAVVLSFS RIAYILPANESFGPLQ

ISLGRTVKDIFKFMVI FIMVFVAFMIGMFNLY SYYIGAKQNEAFTTVE

ESFKTLFWAIFGLSEV KSVVINYNHKFIENIG YVLYGVYNVTMVIVLL

NMLIAMINSSFQEIED DADVEWKFARAKLWFS YFEEGRTLPVPFNLVP

SPKSLFYLLLKLKKWI SELFQGHKKGFQEDAE MNKINEEKKLGILGSH

EDLSKLSLDKKQVGHN KQPSIRSSEDFHLNSF NNPPRQYQKIMKRLIK

RYVLQAQIDKESDEVN EGELKEIKQDISSLRY ELLEEKSQNTEDLAEL

IRELGEKLSMEPNQEE TNR

g5802234 93 SRDPPASASQVTGIR

g6005868 94 MASLSRALRVAAAHPR QSPTRGMGPCNLSSAA GPTAEKSVPYQRTLKE

GQGTSVVAQGPSRPLP STANVVVIGGGSLGCQ TLYHLAKLGMSGAVLL

ERERLTSGTTWHTAGL LWQLRPSDVEVELLAH TRRVVSRELEEETGLH

TGWIQNGGLFIASNRQ RLDEYKRLMSLGKAYG VESHVLSPAETKTLYP

LMNVDDLYGTLYVPHD GTMDPAGTCTTLARAA SARGAQVIENCPVTGI

RVWTDDFGVRRVAGVE TQHGSIQTPCVVNCAG VWASAVGRMAGVKVPL

VAMHHAYVVTERIEGI QSFTLLPTLEYSGTVS AHCNLRLPGSSNSRAS

ASHVAGIKCARHHTRL IFFCILVETEFHHVAK AGLELLSSGNPPISDF

QSARITGVSHHA

g604969 95 LLWVLLWATVLGLLCQ RLAARLGVVTGKDLGE VCHLYYPKSESRSVAQ

SGVQWCDVSSLQPLPP RCPAPSSG

g6650810 96 METESGSVAQAGVQWH NLGSLQPPPSRLKQLS YLSLPSSWDYRCTPPH

PANFLYFNRDGISPCC PGWSPTPKLTQSTHLG LSKC

g6665594 97 MAQFYYKRNVNAPYRD RIPLRIVRAESELSPS EKAYLNAVEKGDYASV

KKSLEEAEIYFKININ CIDPLGRTALLIAIEN ENLELIELLLSFNVYV

GDALLHAIRKEVVGAV ELLLNHKKPSGEKQVP PILLDKQFSEFTPDIT

PIILAAHTNNYEIIKL LVQKGVSVPRPHEVRC NCVECVSSSDVDSLRH

SRSRLNIYKALASPSL IALSSEDPFLTAFQLS WELQELSKVENEFKSE

YEELSRQCKQFAKDLL DQTRSSRELEIILNYR DDNSLIEEQSGNDLAR

LKLAIKYRQKEFVAQP NCQQLLASRWYDEFPG WRRRHWAVKMVTCFII

GLLFPVFSVCYLIAPK SPLGLFIRKPFIKFIC HTASYLTFLFLLLLAS

QHIDRSDLNRQGPPPT IVEWMILPWVLGFIWG EIKQMWDGGLQDYIHD

WWNLMDFVMNSLYLAT ISLKIVAFVKYSALNP RESWDMWHPTLVAEAL

FAIANIFSSLRLISLF TANSHLGPLQISLGRM LLDILKFLFIYCLVLL

AFANGLNQLYFYYEET KGLTCKGIRCEKQNNA FSTLFETLQSLFWSIF

GLINLYVTNVKAQHEF TEFVGATMFGTYNVIS LVVLLNMLIAMMNNSY

QLIADHADIEWKFART KLWMSYFEEGGTLPTP FNVIPSPKSLWYLIKW

IWTHLCKKKMRRKPES FGTIGRRAADNLRRHH QYQEVMRNLVKRYVAA

MIRDAKTEEVARQQAA GPLERNIQLESRGLAS RGDLSIPGLSEQCVLV

DHRERNTDTLGLQVGK RVCPFKSEKVVVEDTV PIIPKEKHAKEEDSSI

DYDLNLPDTVTHEDYV TTRL

g6665596 98 MAQFYYKRNVNAPYRD RIPLRIVRAESELSPS EKAYLNAVEKGDYASV

KKSLEEAEIYFKININ CIDPLGRTALLIAIEN ENLELIELLLSFNVYV

GDALLHAIRKEVVGAV ELLLNHKKPSGEKQVP PILLDKQFSEFTPDIT

PIILAAHTNNYEIIKL LVQKGVSVPRPHEVRC NCVECVSSSDVDSLRH

SRSRLNIYKALASPSL IALSSEDPFLTAFQLS WELQELSKVENEFKSE

YEELSRQCKQFAKDLL DQTRSSRELEIILNYR DDNSLIEEQSGNDLAR

LKLAIKYRQKEFVAQP NCQQLLASRWYDEFPG WRRRHWAVKMVTCFII

GLLFPVFSVCYLIAPK SPLGLFIRKPFIKFIC HTASYLTFLFLLLLAS

QHIDRSDLNRQGPPPT IVEWMILPWVLGFIWG EIKQMWDGGLQDYIHD

WWNLMDFVMNSLYLAT ISLKIVAFVKYSALNP RESWDMWHPTLVAEAL

FAIANIFSSLRLISLF TANSHLGPLQISLGRM LLDILKFLFIYCLVLL

AFANGLNQLYFYYEET KGLTCKGIRCEKQNNA FSTLFETLQSLFWSIF

GLINLYVTNVKAQHEF TEFVGATMFGTYNVIS LVVLLNMLIAMMNNSY

QLIARRAADNLRRHHQ YQEVMRNLVKRYVAAM IRDAKTEEGLTEENFK

ELKQDISSFRFEVLGL LRGSKLSTIQSANASK ESSNSADSDEKSDSEE

EVARQQAAGPLERNIQ LESRGLASRGDLSIPG LSEQCVLVDHRERNTD

TLGLQVGKRVCPFKSE KVVVEDTVPIIPKEKH AKEEDSSIDYDLNLPD

TVTHEDYVTTRL

g6690167 99 MRTKSEREIHLCVLGF FXFFFETGSRSVAQAG VQRHSHGSLQPRPPGL

IQFSHLSLPSSWDYRH APPHLVNFL

g6690252 100 RFFFFFFFEESRSFAQ AGVQWRYLGSLQPPPP GFTRFSCLSLLSSWDY

RRPPPRPANFLYF

g7243280 101 ELSFPLLSLDFGAHQG LGSADMGDMKTPDFDD LLAAFDIPDIDANEAI

HSGPEENEGPGGPGKP EPGVGSESEDTAAASA GDGPGVPAQASDHGLP

PPDISVVSVIVKNTVC PEQSEALAGGSAGDGA QAAGVTKEGPVGPHRM

QNGFGSPEPSLPGTPH SPAPPSGGTWKEKGME GKTPLDLFAHFGPEPG

DHSDPLPPSAPSPTRE GALTPPPFPSSFELAQ ENGPGMQPPVSSPPLG

ALKQESCSPHHPQVLA QQGSGSSPKATDIPAS ASPPPVAGVPFFKQSP

GHQSPLASPKVPVCQP LKEEDDDEGPVDKSSP GSPQSPSSGAEAADED

SNDSPASSSSRPLKVR IKTIKTSCGNITRTVT QVPSDPDPPAPLAEGA

FLAEASLLKLSPATPT SEGPKVVSVQLGDGTR LKGTVLPVATIQNAST

AMLMAASVARKAVVLP GGTATSPKMIAKNVLG LVPQALPKADGRAGLG

TGGQKVNGASVVMVQP SKTATGPSTGGGTVIS RTQSSLVEAFNKILNS

KNLLPAYRPNLSPPAE AGLALPPTGYRCLECG DAFSLEKSLARHYDRR

SMRIEVTCNHCARRLV FFNKCSLLLHAREHKD KGLVMQCSHLVMRPVA

LDQMVGQPDITPLLPV AVPPVSGPLALPALGK GEGAITSSAITTVAAE

APVLPLSTEPPAAPAT SAYTCFRCLECKEQCR DKAGMAAHFQQLGPPA

PGATSNVCPTCPMMLP NRCSFSAHQRMHKNRP PHVCPECGGNFLQANF

QTHLREACLHVSRRVG YRCPSCSVVFGGVNSI KSHIQTSHCEVFHKCP

ICPMAFKSGPSAHAHL YSQHPSFQTQQAKLIY KCAMCDTVFTHKPLLS

SHFDQHLLPQRVSVFK CPSCPLLFAQKRTMLE HLKNTHQSGRLEETAG

KGAGGALLTPKTEPEE LAVSQGGAAPATEESS SSSEEEEVPSSPEPPR

PAKRPRRELGSKGLKG GGGGPGGWTCGLCHSW FPERDEYVAHMKKEHG

KSVKKFPCRLCERSFC SAPSLRRHVRVNHEGI KRVYPCRYCTEGKRTF

SSRLILEKHVQVRHGL QLGAQSPGRGTTLARG SSARAQGPGRKRRQSS

DSCSEEPDSTTPPAKS PRGGPGSGGHGPLRYR SSSSTEQSLMMGLRVE

DGAQQCLDCGLCFASP GSLSRHRFISHKKRRG VGKASALGLGDGEEEA

PPSRSDPDGGDSPLPA SGGPLTCKVCGKSCDS PLNLKTHFRTHGMAFI

RARQGAVGDN

g7305597 102 MSQSPRFVTRRGGSLK AAPGAGTRRNESQDYL LMDELGDDGYPQLPLP

PYGYYPSFRGNENRLT HRRQTILREKGRRLAN RGPAYMFNDHSTSLSI

EEERFLDAVEYGNIPV VWKMLEECHSLNVNCV DYMGQNALQLAVANEH

LEITELLLKKENLSRV GDALLLAISKGYVRIV EAILNHPSFAEGKRLA

TSPSQSELQQDDFYAY DEDGTRFSHDVTPIIL AAHCQEYEIVHTLLRK

GARIERPHDYFCKCTE CSQKQKHDSFSHSRSR INAYKGLASPAYLSLS

SEDPVMTALELSNELA VLANIEKEFKNDYRKL SMQCKDFVVGLLDLCR

NTEEVEAILNGDAETR QPGDFGRPNLSRLKLA IKDEVKKFVAHPNCQQ

QLLSIWYENLSGLRQQ TMAVKFLVVLAVAIGL PFLALIYWCAPCSKMG

KILPRPFMKFVAHAAS FTIFLGLLVMNAADRF EGTKLLPNETSTDNAR

QLFRMKTSCFSWMEML IISWVIGMIWAECKEI WTQGPKEYLFELWNML

DFGMLAIFAASFIARF MAFWHASKAQSIIDAN DTLKDLTKVTLGDNVK

YYNLARIKWDPTDPQI ISEGLYAIAVVLSFSR IAYILPANESFGPLQI

SLGRTVKDIFKFMVIF IMVFVAFMIGMFNLYS YYIGAKQNEAFTTVEE

SFKTLFWAIFGLSEVK SVVINYNHKFIENIGY VLYGVYNVTMVIVLLN

MLIAMINSSFQEIEDD ADVEWKFARAKLWFSY FEEGRTLPVPFNLYPS

PKSLLYLLLKFKKWMC ELIQGQKQGFQEDAEM NKRNEEKKFGISGSHE

DLSKFSLDKNQLAHNK QSSTRSSEDYHLNSFS NPPRQYQKIMKRLIKR

YVLQAQIDKESDEVNE GELKEIKQDISSLRYE LLEEKSQNSEDLAELI

RKLGERLSLEPKLEES RR

g7512448 103 GFLPATKNLLNEKNHG VLHTSVVLLTEMCERS PDMLAHFRENEKLVPQ

LVRILKNLIMSGYSPG HDVSGISDPFLQVRIL RLLRILGRNDDDSSEA

MNDILAQVATNTETSK NVGNAILYETVLTIMD IKSESGLRVLAINILG

RFLLNNDKNIRYVALT SLLKTVQTDHNAVQRH RSTIVDCLKDLDVSIK

RRAMELSFALVNGNNI RGMMKELLYFLDSCEP EFKADCASGIFLAAEK

YAPSKRWHIDTIMRVL TTAGSYVRDDAVPNLI QLITNSVEMHAYTVQR

LYKAILGDYSQQPLVQ VAAWCIGEYGDLLVSG QCEEEEPIQVTEDEVL

DILESVLISNMSTSVT RGYALTAIMKLSTRFT CTVNRIKKVVSIYGSS

IDVELQRRAVEYNALF KKYDHMRSALLERMPV MEKVTTNGPTEIVQTN

GETEPAPLETKPPPSG PQPTSQANDLLDLLGG NDITPVIPTAPTSKPS

SAGGELLDLLGDINLT GSHSVSQAGVQWDYLG SLQPLPPAFR

g7522630 104 MWPNGSSLGPCFRPTN ITLEERRLIASPWFAA SFCVVGLASNLLALSV

LAGARQGGSHTRSSFL TFLCGLVLTDFLGLLV TGTIVVSQHAALFEWH

AVDPGCRLCRFMGVVM IFFGLSPLLLGAAMAS ERYLGITRPFSRPAVA

SQRRAWATVGLVWAAA LALGLLPLLGVGRYTV QYPGSWCFLTLGAESG

DVAFGLLFSMLGGLSV GLSFLLNTVSVATLCH VYHGQEAAQQRPRDSE

VEMMAQLLGIMVVASV CWLPLLVFIAQTVLRN PPAMSPAGQLSRTTEK

ELLIYLRVATWNQILD PWVYILFRRAVLRRLQ PRLSTRPRRSLTLWPS

LEYSGTISAHCNLRLP GSSDSRASASRAAGIT GVSHCARPCMLFDPEF

DLLAGVQLLPFEPPTG KALSRKD

g7669477 105 MDIEDEENMSSSSTDV KENRNLDNVSPKDGST PGPGEGSQLSNGGGGG

PGRKRPLEEGSNGHSK YRLKKRRKTPGPVLPK NALMQLNEIKPGLQYT

LLSQTGPVHAPLFVMS VEVNGQVFEGSGPTKK KAKLHAAEKALRSFVQ

FPNASEAHLAMGRTLS VNTDFTSDQADFPDTL FNGFETPDKAEPPFYV

GSNGDDSFSSSGDLSL SASPVPASLAQPPLPV LPPFPPPSGKNPVMIL

NELRPGLKYDFLSESG ESHAKSFVMSVVVDGQ FFEGSGRNKKLAKARA

AQSALAAIFNLHLDQT PSRQPIPSEGLQLHLP QVLADAVSRLVLGKFG

DLTDNFSSPHARRKVL AGVVMTTGTDVKDAKV ISVSTGTKCINGEYMS

DRGLALNDCHAEIISR RSLLRFLYTQLELYLN NKDDQKRSIFQKSERG

GFRLKENVQFHLYIST SPCGDARIFSPHEPIL EGSRSYTQAGVQWCNH

GSLQPRPPGLLSDPST STFQGAGTTEPADRHP NRKARGQLRTKIESGE

GTIPVRSNASIQTWDG VLQGERLLTMSCSDKI ARWNVVGIQGSLLSIF

VEPIYFSSIILGSLYH GDHLSRAMYQRISNIE DLPPLYTLNKPLLSGI

SNAEARQPGKAPNFSV NWTVGDSAIEVINATT GKDELGRASRLCKHAL

YCRWMRVHGKVPSHLL RSKITKPNVYHESKLA AKEYQAAKARLFTAFI

KAGLGAWVEKPTEQDQ FSLTP

g7669479 106 MDIEDEENMSSSSTDV KENRNLDNVSPKDGST PGPGEGSQLSNGGGGG

PGRKRPLEEGSNGHSK YRLKKRRKTPGPVLPK NALMQLNEIKPGLQYT

LLSQTGPVHAPLFVMS VEVNGQVFEGSGPTKK KAKLHAAEKALRSFVQ

FPNASEAHLAMGRTLS VNTDFTSDQADFPDTL FNGFETPDKAEPPFYV

GSNGDDSFSSSGDLSL SASPVPASLAQPPLPV LPPFPPPSGKNPVMIL

NELRPGLKYDFLSESG ESHAKSFVMSVVVDGQ FFEGSGRNKKLAKARA

AQSALAAIFNLHLDQT PSRQPIPSEGLQLHLP QVLADAVSRLVLGKFG

DLTDNFSSPHARRKVL AGVVMTTGTDVKDAKV ISVSTGTKCINGEYMS

DRGLALNDCHAEIISR RSLLRFLYTQLELYLN NKDDQKRSIFQKSERG

GFRLKENVQFHLYIST SPCGDARIFSPHEPIL EGSRSYTQAGVQWCNH

GSLQPRPPGLLSDPST STFQGAGTTEPADRHP NRKARGQLRTKIESGE

GTIPVRSNASIQTWDG VLQGERLLTMSCSDKI ARWNVVGIQGSLLSIF

VEPIYFSSIILGSLYH GDHLSRAMYQRISNIE DLPPLYTLNKPLLSGI

SNAEARQPGKAPNFSV NWTVGDSAIEVINATT GKDELGRASRLCKHAL

YCRWMRVHGKVPSHLL RSKITKPNVYHESKLA AKEYQAAKVH

g7770147 107 MEVLLFLFIFETESCS VIRLECSGSLQPPPPR FKQFSCLSLPSSWDYR

CPPPCPINFCIFGTDR VSPCWPGWSRSR

g7706747 108 MAQFYYKRNVNAPYRD RIPLRIVRAESELSPS EKAYLNAVEKGDYASV

KKSLEEAEIYFKININ CIDPLGRTALLIAIEN ENLELIELLLSFNVYV

GDALLHAIRKEVVGAV ELLLNHKKPSGEKQVP PILLDKQFSEFTPDIT

PIILAAHTNNYEIIKL LVQKGVSVPRPHEVRC NCVECVSSSDVDSLRH

SRSRLNIYKALASPSL IALSSEDPFLTAFQLS WELQELSKVENEFKSE

YEELSRQCKQFAKDLL DQTRSSRELEIILNYR DDNSLIEEQSGNDLAR

LKLAIKYRQKEFVAQP NCQQLLASRWYDEFPG WRRRHWAVKMVTCFII

GLLFPVFSVCYLIAPK SPLGLFIRKPFIKFIC HTASYLTFLFLLLLAS

QHIDRSDLNRQGPPPT IVEWMILPWVLGFIWG EIKQMWDGGLQDYIHD

WWNLMDFVMNSLYLAT ISLKIVAFVKYSALNP RESWDMWHPTLVAEAL

FAIANIFSSLRLISLF TANSHLGPLQISLGRM LLDILKFLFIYCLVLL

AFANGLNQLYFYYEET KGLTCKGIRCEKQNNA FSTLFETLQSLFWSIF

GLINLYVTNVKAQHEF TEFVGATMFGTYNVIS LVVLLNMLIAMMNNSY

QLIADHADIEWKFART KLWMSYFEEGGTLPTP FNVIPSPKSLWYLIKW

IWTHLCKKKMRRKPES FGTIGRRAADNLRRHH QYQEVMRNLVKRYVAA

MIRDAKTEEGLTEENF KELKQDISSFRFEVLG LLRGSKLSTIQSANAS

KESSNSADSDEKSDSE GNSKDKKKNFSLFDLT TLIHPRSAAIASERHN

ISNGSALVVQEPPREK QRKVNFVTDIKNFGLF HRRSKQNAAEQNANQI

FSVSEEVARQQAAGPL ERNIQLESRGLASRGD LSIPGLSEQCVLVDHR

ERNTDTLGLQVGKRVC PFKSEKVVVEDTVPII PKEKHAKEEDSSIDYD

LNLPDTVTHEDYVTTR L

g8922960 109 MESYSVTQAGVQWHEL CSLQPSPPRFREMCIE QDGRVHLTVVYFGKEE

INEVKGVLENTSKAAN FRNFTFIQLNGEFSRG KGLDVGARFWKGSNVL

LFFCDVDIYFTSEFLN TCRLNTQPGKKVFYPV LFSQYNPGIIYGHHDA

VPPLEQQLVIKKETGF WRDFGFGMTCQYRSDF INIGGFDLDIKGWGGE

DVHLYRKYLHSNLIVV RTPVRGLFHLWHEKRC MDELTPEQYKMCMQSK

AMNEASHGQLGMLVFR HEIEAHLRKQKQKTSS KKT

g8923251 110 MDITLVRKELQELQNL YKQNSTHTAQQAELIQ QLQVLNMDTQKVLRNQ

EDVHTAESISYQKLYN ELHICFETTKSNEAML RQSVTNLQDQLLQKEQ

ENAKLKEKLQESQGAP LPLPQESDPDYSAQVP HRPSLSSLETLMVSQK

SEIEYLQEKLKIANEK LSENISANKGFSRKSI MTSAEGKHKEPPVKRS

RSLSPKSSFTDSEELQ KLRKAERKIENLEKAL QLKSQENDELRDAHEK

RKERLQMLQTNYRAVK EQLKQWEEGSGMTEIR KIKRADPQQLRQEDSD

AVWNELAYFKRENQEL MIQKMNLEEELDELKV HISIDKAAIQELNRCV

AERREEQLFRSGEDDE VKRSTPEKNGKEMLEQ TLQKVIELENRLKSFE

KRSRKLKEGNKKLMKE NDFLKSLLKQQQEDTE TREKELEQIIKGSKDV

EKENTELQVKISELET EVTSLRRQVAEANALR NENEELINPMEKSHQS

ADRAKSEMATMKVRSG RYDCKTTMTKVKFKAA KKNCSVGRHHTVLNHS

IKVMSNVFENLSKDGW EDVSESSSDSEAQTSQ TLGTIIVETSQKISPT

EDGKDQKESDPTEDSQ TQGKEIVQTYLNIDGK TPKDYFHDKNAKKPTF

QKKNCKMQKSSHTAVP TRVNREKYKNITAQKS SSNIILLRERIISLQQ

QNSVLQNAKKTAELSV KEYKEVNEKLLHQQQV SDQRFQTSRQTIKKLN

LDLAGLRKEKEDLLKK LESSSEITSLAEENSQ VTFPRIQVTSLSPSRS

MDLEMKQLQYKLKNAT NELTKQSSNVKTLKFE LLAKEEHIKEMHEKIS

RMERDITMKRHLIEDL KFRQKVNLESNKSFSE MLQNLDKKVKTLTEEC

SNKKVSIDSLKQRLNV AVKEKSQYEQMYQKSK EELEKKDLKLTLLVSR

ISETESAMAEIETAAS KQLQELALQSEQVLEG AQKTLLLANEKVEEFT

TFVKALAKELQNDVHV VRRQIRELKKMKKNRD ACKTSTHKAQTLAASI

LNISRSDLEEILDTED QVEIEKTKIDAENDKE WMLYIQKLLEGQSLTL

SPRLKCNGAIMAHQNL RLPDSSSSASAS

g8923273 111 MKVVPEKNAVRILWGR ERGARAMGAQRLLQEL VEDKTRWMKWEGKRVE

LPDSPRSTFLLAFSPD RTLLASTHVNHNIYIT EVKTGKCVHSLIGHRR

TPWCVTFHPTISGLIA SGCLDGEVRIWDLHGG SESWFTDSNNAIASLA

FHPTAQLLLIATANEI HFWDRSRREPFAVVKT ASEMERVRLVRFDPLG

HYLLTAIVNPSNQQGD DEPEIPIDGTELSHYR QRALLQSQPVRRTPLL

HNFLHMLSSRSSGIQT EPFHPPEQASSTQQDQ GLLNRPSAFSTVQSST

AGNTLRNLSLGPTRRS LGGPLSSHPSRYHREI APGLTGSEWTRTVLSL

NSRSEAESMPPPRTSA SSVSLLSVLRQQEGGS QASVYTSATEGRGFPA

SGLATESDGGNGSSQN NSGSIRHELQCDLRRF FLEYDRLQELDQSLSG

EAPQTQQAQEMLNNNI ESERPGPSHQPTPHSS ENNSNLSRGHLNRCRA

CHNLLTFNNDTLRWER TTPNYSSGEASSSWQV PSSFESVPSSGSQLPP

LERTEGQTPSSSRLEL SSSASPQEERTVGVAF NQETGHWERIYTQSSR

SGTVSQEALHQDMPEE SSEEDSLRRRSLALSP RLEYSGAILAHCKLRL

PGSCHSPASASQVAGT TGAHHHARLIFAFLVE MEFHHVSQAGLELLTS

GDLPTSASQVLGLQA

g8923360 112 MVHSPRSLVANPSQVL FFLSFLFFFFLRQSFA LVAQAGVQWRNLGSLQ

PPPPGFKQFSCLSLLS SWDYRHAPPCPAYFVF LVDMGFPHVGQTGLEL

LTSGDPPASASQSAGI TGGSHRAQPTSSNPYG IVFFFLPVKTFSGMSQ

EAGDCRET

g8923452 113 MPTATGLTLLTSASSA ISDPGGEVSAPWGGLR TWTQPLRCWERLLPPP

GDPRTVAENTQQDECG LPGSCPARPLSRKPEC GREGILPCCSSSAWPE

GSFRPFQMNLFSFLSF FFLFFFFLRWSLTLSP RLECSSAISAHCNLRL

PGSSNSPALASQVAGI TGICHHARQIFVFLVE TGFCHVGQAGLELLIS

GDSPASAFQSAGIIGV SHRARPGSVFLARSEE SLYLRPGQQSQEVKV

g8923454 114 MLLVDADQPEPMRSGA RELALFLTPEPGAEAK EVEETIEGMLLRLEEF

CSLADLIRSDTSQILE ENIPVLKAKLTEMRGI YAKVDRLEAFVKMVGH

HVAFLEADVLQAERDH GAFPQALRRWLGSAGL PSFRNVECSGTIPARC

NLRLPGSSDSPASASQ VAGITEVTCTGARDVR AAHTV

g8923691 115 MSVYSGKVLLQTTPPH VIGQLDKLIREVSTLD GVLEVRNEHFWTLGFG

SLAGSVHVRIRRDANE QMVLAHVTNRLYTLVS TLTVQIFKDDWIRPAL

LSGPVAANVLNFSDHH VIPMPLLKGTDGLNPY VHFLWKINFFLFFDME

SLSVAQAGVQWHDLGS LQPHLPGSSNSACLSL PSSWDYRHAPPHLPNF

CIISKDGVLPCWPCWS

g8924071 116 MESRSVAQTGVHWHNL SSLQPLPPRFKQFSCL SLRSSWDYTHLPPCLA

NFFVFLVETAFRHVGQ AGLKLLTSGDQPTSAS QSAGITGISHRTQPVG

RFLITDSIFLFVTDLL KFSISS

g8924204 117 MSKVLGGPFSKGHTAS DKYFQIFHNISFFETE SCSVAQAGVQWCNLGS

LQALPPRFTPFSCLSL PSSWDYRHPPPCPDNV FVFSVETGFHCVSQDG

LNLLTL

g8980667 118 MAQGTLIRVTPEQPTH AVCVLGTLTQLDICSS APEDCTSFSINASPGV

VVDIAHSPPAKKKSTG SSTWPLDPGVEVTLTM KAASGSTGDQKVQISY

YGPKTPPVKALLYLTA VDGVSPCHPGWSAMHD LAHCNLRLQVQAILCF

SVPSSWTTGACHHAWL IFVFLVEMEFHHVGQA GLELLTSGDLPASGSQ

SARITGMNHCARPSIF LILKYL

g9716913 119 MSQSPAFGPRRGSSPR GAAGAAARRNESQDYL LMDSELGEDGCPQAPL

PCYGYYPCFRGSDNRL AHRRQTVLREKGRRLA NRGPAYMFSDRSTSLS

IEEERFLDAAEYGNIP VVRKMLEECHSLNVNC VDYMGQNALQLAVANE

HLEITELLLKKENLSR VGDALLLAISKGYVRI VEAILSHPAFAEGKRL

ATSPSQSELQQDDFYA YDEDGTRFSHDVTPII LAAHCQEYEIVHTLLR

KGARIERPHDYFCKCN DCNQKQKHDSFSHSRS RINAYKGLASPAYLSL

SSEDPVMTALELSNEL AVLANIEKEFKNDYKK LSMQCKDFVVGLLDLR

RNTEEVEAILNGDVET LQSGDHGRPNLSRLKL AIKYEVKKMGKIMRGP

FMKFVAHAASFTIFLG LLVMNAADRFEGTKLL PNETSTDNAKQLFRMK

TSCFSWMEMLIISWVI GMIWAECKEIWTQGPK EYLFELWNMLDFGMLA

IFAASFIARFMAFWHA SKAQSIIDANDTLKDL TKVTLGDNVKYYNLAR

IKWDPSDPQIISEGLY AIAVVLSFSRIAYTLP ANESFGPLQISLGRTV

KDIFKFMVIFIMVFVA FMIGMFNLYSYYIGAK QNEAFTTVEESFKTLF

WAIFGLSEVKSVVINY NHKFIENIGYVLYGVY NVTMVIVLLNMLIAMI

NSSFQEIEDDADVEWK FARAKLWFSYFEEGRT LPVPFNLVPSPKSLFY

LLLKLKKWISELFQGH KKGFQEDAEMNKINEE KKLGILGSHEDLSKLS

LDKKQVGHNKQPSIRS SEDFHLNSFNNPPRQY QKIMKRLIKRYVLQAQ

IDKESDEVNEGELKEI KQDISSLRYELLEEKS QNTEDLAELIRELGEK

LSMEPNQEETNR

g9966865 120 MLRNSTFKNMQRRHTT LREKGRRQAIRGPAYM FNEKGTSLTPEEERFL

DSAEYGNIPVVRKMLE ESKTLNFNCVDYMGQN ALQLAVGNEHLEVTEL

LLKKENLARVGDALLL AISKGYVRIVEAILNH PAFAQGQRLTLSPLEQ

ELRDDDFYAYDEDGTR FSHDITPIILAAHCQE YEIVHILLLKGARIER

PHDYFCKCNECTEKQR KDSFSHSRSRMNAYKG LASAAYLSLSSEDPVL

TALELSNELARLANIE TEFKNDYRKLSMQCKD FVVGVLDLCRDTEEVE

AILNGDVNFQVWSDHH RPSLSRIKLAIKYEVK KFVAHPNCQQQLLTMW

YENLSGLR(QQSIAVKF LAVFGVSI)GLPFLAIA YWIAPCSKLGRTLRSP

FMKFVAHAVSFTIFLG LLVVNASDRFEGVKTL PNETFTDYPKQIFRVK

TTQFSWTEMLIMKWVL GMIWSECKEIWEEGPR EYVLHLWNLLDFGMLS

IFVASFTARFMAFLKA TEAQLYVDQHVQDDTL HNVSLPPEVAYFTYAR

DKWWPSDPQIISEGLY AIAVVLSFSRIAYILP ANESFGPLQISLGRTV

KDIFKFMVIFIMVFVA FMIGMFNLYSYYRGAK YNPAFTTVEESFKTLF

WSIFGLSEVISVVLKY DHKFIENIGYVLYGVY NVTMVVVLLNMLIAMI

NNSYQEIEEDADVEWK FARAKLWLSYFDEGRT LPAPFNLVPSPKSFYY

LIMRIKMCLIKLCKSK AKSCENDLEMGMLNSK FKKTRYQAGMRNSENL

TANNTLSKPTRYQKIM KRLIKRYVLKAQVDRE NDEVNEGELKEIKQDI

SSLRYELLEEKSQATG ELADLIQQLSEKFGKN LNKDHLRVNKGKDI

g9967846 121 MDDGCPQLPLPPHGYY PSLRGTDNRLTHRRQT VLREKGRRLANRGPAY

MFNDHSTTLSIEEERF LDAAEYGNIPVVRKML EECLSLNVNCVDYMGQ

NALQLAVANEHLEITE LLLKKENLSRVGDALL LAISKGYVRIVEAILS

HPAFAEGKRLATSPSQ SELQQDDFYAYDEDGT RFSHDVTPIILAAHCQ

EYEIVHTLLRKGARIE RPHDYFCKCSECNQKQ KHDSFSHSRSRINAYK

GLASPAYLSLSSEDPV MTALELSNELAVLANI EKEFKNDYKKLSMQCK

DFVVGLLDLCRNTEEV EAILNGDVETCQSGDQ GRPNLSRLKLAIKYEV

KKFVAHPNCQQQLLSI WYENLSGLRQQTMAVK FLVVLGVAIGLPFLAL

IYWCAPCSKMGKIMRG PFMKFVAHAASFTIFL GLLVMNAADRFEGTKL

RPNETSTDNAKQLFRM KTSCFSWMEMLIISWV IGMIWAECKEIWAQGP

KEYLFELWNMLDFGML AIFAASFIARFMAFWH ASKAQSIIDANDTLKD

LTKVTLGEDVKYYNLA RIKWDPSDPQIISEGL YAIAVVLSFSRIAYIL

PANESFGPLQISLGRT VKDIFKFMVIFIMVFV AFMIGMFNLYSYYIGA

KQNEAFTTVEESFKTL FWAIFGLSEVKSVVIN YNHKFIENIGYVLYGV

YNVTMVIVLLNMLIAM INSSFQEIEDDADVEW KFARAKLWFSYFEEGR

TLPVPFNLVPSPKSLL YLLLKFKKWGFELFQG HKKAFQEDAEMNKRNE

EKKFGILGSHEDLSKL SVDKKQLGQNKQSSIR SSEDFHLNSFNNPPRQ

YQKIMKRLIKRYVLQA QIDKESDEVNEGELKE IKQDISSLRYELLEEK

SQNTEDLAELIRKLGE KLSSEPKQEEINR

g9967886 122 MFNDHSTTLSIEEERF LDAAEYGNIPVVRKML EECLSLNVNCVDYMGQ

NALQLAVANEHLEITE LLLKKENLSRVGDALL LAISKGYVRIVEAILS

HPAFAEGKRLATSLSQ SELQQDDFYAYDEDGT RFSHDVTPIILAAHCQ

EYEIVHTLLRKGARIE RPHDYFCKCSECNQKQ KHDSFSHSRSRINAYK

GLASPAYLSLSSEDPV MTALELSNELAVLANI EKEFKNDYKKLSMQCK

DFVVGLLDLCRNTEEV EAILNGDIETCQPGDQ GRPNLSRLKLAIKYEV

KKFVAHPNCQQQLLSI WYENLSGLRQQTMAVK FLVVLGVAIGLPFLAL

IYWCAPCSKMGKIMRG PFMKFVAHAASFTIFL GLLVMNAADRFEGTKL

RPNETSTDNAKQLFRM KTSCFSWMEMLIISWV IGMVWAECKEIWAQGP

KEYLFELWNMLDFGML AIFAASFIARFMAFWH ASKAQSIIDANDTLKD

LTKVTLGEDVKYYNLA RIKWDPSDPQIISEGL YAIAVVLSFSRIAYIL

PANESFGPLQISLGRT VKDIFKFMVIFIMVFV AFMIGMFNLYSHYIGA

KQNEAFTTYVISDVLT MEIAD

g9967888 123 MDDGCPQLPLPPHGYY PSLRGTDNRLTHRRQT VLREKGRRLANRGPAY

MFNDHSTTLSIEEERF LDAAEYGNIPVVRKML EECLSLNVNCVDYMGQ

NALQLAVANEHLEITE LLLKKENLSRVGDALL LAISKGYVRIVEAILS

HPAFAEGKRLATSPSQ SELQQDDFYAYDEDGT RFSHDVTPIILAAHCQ

EYEIVHTLLRKGARIE RPHDYFCECSECNQKQ KHDSFSHSRSRINAYK

GLASPAYLSLSSEDPV MTALELSNELAVLANI EKEFKNDYKKLSMQCK

DFVVGLLDLCRNTEEV EAILNGDVETCQPGDQ GRPNLSRLKLAIKYEV

KKFVAHPNCQQQLLSI WYENLSGLRQQTMAVK FLVVLGVAIGLPFLAL

IYWCAPCSKMGKIMRG PFMKFVAHAASFTIFL GLLVMNAADRFEGTKL

RPNETSTDNAKQLFRM KTSCFSWMEMLIISWV IARIKWDPSDPQIISE

GLYAIAVVLSFSRIAY ILPANESFGPLQISLG RTVKDIFKFMVIFIMV

FVAFMIGMFHLYSYYI GAKQNEAFTTVEESFK TLFWAIFGLSEVKSVV

INYNHKFIENIGYVLY GVYNVTMVIVLLNMLI AMINSSFQEIEDDADV

EWKFARAKLWFSYFEE GRTLPVPFNLVPSPKS LLYLLLKFKKWGFELF

QGHKKAFQEDAEMNKR NEEKKFGILGSHEDLS KLSVDKKQLGQNKQSS

IRSSEDFHLNSFNNPP RQYQKIMKRLIKRYVL QAQIDKESDEVNEGEL

KEIKQDISSLRYELLE EKSQNTEDLAELIRKL GEKLSSEPKQEEINR

g9716913 124 MSQSPAFGPRRGSSPR GAAGAAARRNESQDYL LMDSELGEDGCPQAPL

PCYGYYPCFRGSDNRL AHRRQTVLREKGRRLA NRGPAYMFSDRSTSLS

IEEERFLDAAEYGNIP VVRKMLEECHSLNVNC VDYMGQNALQLAVANE

HLEITELLLKKENLSR VGDALLLAISKGYVRI VEAILSHPAFAEGKRL

ATSPSQSELQQDDFYA YDEDGTRFSHDVTPII LAAHCQEYEIVHTLLR

KGARIERPHDYFCKCN DCNQKQKHDSFSHSRS RINAYKGLASPAYLSL

SSEDPVMTALELSNEL AVLANIEKEFKNDYKK LSMQCKDFVVGLLDLR

RNTEEVEAILNGDVET LQSGDHGRPNLSRLKL AIKYEVKKMGKIMRGP

FMKFVAHAASFTIFLG LLVMNAADRFEGTKLL PNETSTDNAKQLFRMK

TSCFSWMEMLIISWVI GMIWAECKEIWTQGPK EYLFELWNMLDFGMLA

IFAASFIARFMAFWHA SKAQSIIDANDTLKDL TKVTLGDNVKYYNLAR

IKWDPSDPQIISEGLY AIAVVLSFSRIAYTLP ANESFGPLQISLGRTV

KDIFKFMVIFIMVFVA FMIGMFNLYSYYIGAK QNEAFTTVEESFKTLF

WAIFGLSEVKSVVINY NHKFIENIGYVLYGVY NVTMVIVLLNMLIAMI

NSSFQEIEDDADVEWK FARAKLWFSYFEEGRT LPVPFNLVPSPKSLFY

LLLKLKKWISELFQGH KKGFQEDAEMNKINEE KKLGILGSHEDLSKLS

LDKKQVGHNKQPSIRS SEDFHLNSFNNPPRQY QKIMKRLIKRYVLQAQ

IDKESDEVNEGELKEI KQDISSLRYELLEEKS QNTEDLAELIRELGEK

LSMEPNQEETNR

本发明的NTP肽、相关蛋白、相关肽及其片段、变体、衍生物、同源物和模拟物可用此领域技术人员已知的方法制备，如重组DNA技术、蛋白质合成和分离天然产生的NTP肽、相关蛋白、相关肽及其片段、变体、衍生物和同源物。

NTP肽、相关蛋白或相关肽可用熟知的重组DNA技术方法制备，如列于Sambrook等，(《分子克隆：实验室手册》(Molecular Cloning：A Laboratory Manual)，Cold Spring Harbor Laboratory Press，Cold Spring Harbor，N.Y.[1989])和/或Ausubel等编，《新编分子生物学实验指南》(Current Protocols in Molecular Biology)，GreenPublishers Inc.及Wiley和Sons，N.Y.[1994]的方法。

可获得编码NTP肽、相关蛋白或相关肽的基因或cDNA，例如通过筛选基因组或cDNA文库或通过PCR扩增。用于筛选文库的探针或引物可在其它已知基因或基因片段序列信息的基础上产生，这些基因或基因片段来自相同或相关基因家族，如在其它相关蛋白中发现的保守基序。此外，已鉴定了一种生物编码NTP肽、相关蛋白或相关肽的基因，该基因的所有或一部分可用作探针来鉴定其它生物的同源基因。此种探针或引物可用于筛选认为能表达NTP肽、相关蛋白或相关肽基因的多种组织来源的cDNA文库.通常，可采用高严谨性条件来尽可能减少筛选获得的假阳性数量。

另一种制备编码NTP肽、相关蛋白或相关肽的基因的方法采用化学合成，使用此领域技术人员熟知的方法，如Engels等(Angew.Chem.Intl.Ed.，28：716-734[1989])描述的方法。这些方法尤其包括磷酸三酯、亚磷酰胺、H-膦酸酯方法用于核酸合成。这种化学合成的优选方法是用标准亚磷酰胺化学的聚合物-支持的合成。一般，编码NTP肽、相关蛋白或相关肽的DNA长度为几百个核苷酸。可用这些方法将大于约100个核苷酸的核酸合成为几个片段。然后可将这些片段连接在一起形成全长NTP肽、相关蛋白或相关肽。通常，编码此蛋白质氨基末端的DNA片段具有编码甲硫氨酸的ATG。此甲硫氨酸可以或可不存在于相关蛋白、相关肽或NTP肽的成熟形式中，这取决于宿主细胞中产生的蛋白质是否设计成该细胞分泌的蛋白质。

可将编码相关蛋白、相关肽或NTP肽的基因、cDNA或其片段用标准连接技术插入合适的表达或扩增载体中。通常选择在所用具体宿主细胞中具有功能的载体(即载体与宿主细胞机制相容，从而其中的基因可扩增和/或表达)。编码相关蛋白、相关肽或NTP肽的基因、cDNA或其片段可在原核、酵母、昆虫(杆状病毒系统)和/或真核宿主细胞中扩增/表达。宿主细胞的选择部分取决于相关蛋白，相关肽或NTP肽是否糖基化和/或磷酸化。如果这样，优选酵母、昆虫或哺乳动物宿主细胞。

通常，用于任何宿主细胞的载体包含5’侧翼序列(也称为“启动子”)和其它调节元件如增强子、复制元件的起点、转录终止元件、含供体和受体剪接位点的完整内含子序列、信号肽序列、核糖体结合位点元件、聚腺苷酸化序列、用于插入编码待表达多肽的核酸的多接头区域、及可选择的标记元件。各个这些元件在下面讨论。任选的，载体可包含一尾序列，即位于相关蛋白、相关肽或NTP肽编码序列的5’或3’末端的寡核苷酸分子；该寡核苷酸分子编码聚组氨酸(如6个组氨酸)或其它标志如FLAG、HA(流感病毒血凝索)或存在可商业购买抗体的myc。此尾常在表达多肽时融合于该多肽，可作为从宿主细胞亲和纯化相关蛋白、相关肽或NTP肽的工具。例如可通过柱层析完成亲和纯化，此柱层析采用抗该尾巴的抗体抗作为亲和基质。任选地，随后可通过多种方法某些肽酶从纯化的相关蛋白、相关肽或NTP肽中去除该尾巴。

本领域技术人员可将人免疫球蛋白铰链区和Fc区融合于该相关蛋白、相关肽或NTP肽的N-或C-末端。随后Fc融合蛋白可用A蛋白亲和柱纯化。已知Fc体内可表现出长的药物动力学半衰期且发现融合Fc的蛋白质体内表现出的半衰期显著大于未融合蛋白质。同样，融合的Fc区使得一些分子可二聚化/多聚化而利用其生物活性。

5’侧翼序列可以是同源(即来自与宿主细胞相同的物种和/或品系)、异源(即来自与宿主细胞不同的物种或品质)、杂交的(即一个以上来源的5’侧翼序列的组合)、合成的，或可以是天然的相关蛋白、相关肽或NTP肽基因5’侧翼序列。同样，5’侧翼序列的来源可以是单细胞原核或真核生物、任何脊椎动物或无脊椎动物、或任何植物，只要此5’侧翼序列有功能且可被宿主细胞机制活化。

本发明载体中所用的5’侧翼序列可通过本领域熟知的一些方法来获得。通常，除了相关蛋白、相关肽或NTP肽基因侧翼序列外本文所用的5’侧翼序列前面已通过作图和/或限制性内切酶消化得到鉴定，因此可用合适的限制性内切酶从适当组织来源中分离得到。在一些情况中，此5′侧翼序列的全核苷酸序列可以是已知的。这里可用上述核酸合成或克隆的方法合成此5’侧翼序列。

当5’侧翼所有或仅部分序列已知时，它可用PCR和/或通过筛选基因组文库来获得，筛选所用的合适寡核苷酸和/或5’侧翼序列片段来自相同或另一物种。

当不知道5’侧翼序列时，含5’侧翼序列的DNA片段可从DNA的较大片断中分离，此DNA可包含例如编码序列或甚至另外的基因。分离可通过限制性内切酶消化完成，用一种或多种仔细选择的酶分离适当DNA片段。消化后，所需片段可通过琼脂糖凝胶纯化、

柱或其它本领域技术人员已知的方法来分离。选择适当酶以达到此目的对此领域的一般技术人员是不难懂得的。

复制元件的起点通常是商业购买的原核表达载体的一部分，可协助宿主细胞中载体的扩增。在一些情况中，载体扩增到一定拷贝数对最佳表达相关蛋白、相关肽或NTP肽很重要。如果所选载体不含有复制起始位点，可在已知序列基础上化学合成此起点并连接入载体。转录终止元件一般位于NTP蛋白或NTP/肽编码序列的3’末端，作用是终止相关蛋白、相关肽或NTP肽的转录。通常，原核细胞中的转录终止元件是后面有一聚T序列的富含G-c的片段。虽然可从文库克隆或商业购买此元件作为载体部分，也可用上述核酸合成方法容易地合成。

可选择性标记基因元件编码宿主细胞在选择性培养基中存活和生长所必需的蛋白质。典型的选择标记基因元件编码的蛋白质(a)赋予原核宿主细胞对抗生素或其它毒素的抗性，如氨苄青霉素、四环素或卡那霉素的抗性，(b)弥补细胞的营养缺陷；或(c)提供复合培养基没有的关键营养素。优选的可选择标记是卡那霉素抗性基因、氨苄青霉素抗性基因和四环素抗性基因。

一般称为SD序列(原核生物)或Kozak序列(真核核生物)的核糖体结合元件，是mRNA翻译起始通常必需的。此元件通常位于启动子3’端和待合成的相关蛋白、相关肽或NTP肽编码序列的5’端。各SD序列不同但一般是聚嘌呤(即有高A-G含量)。已鉴定到许多SD序列，本领域普通技术人员可不难用上述方法合成各种SD序列并用于原核载体中。

在需要相关蛋白、相关肽或NTP肽从宿主细胞分泌时，可利用信号序列引导相关蛋白，相关肽或NTP肽分泌到宿主细胞外，可缺失此蛋白质的羧基末端部分以防止膜锚定。通常，信号序列位于相关蛋白/相关肽/NTP肽基因或cDNA的编码区域中，或连接在相关蛋白/相关肽/NTP肽基因编码区的5’末端。已鉴定到许多信号序列，任何一种在所选宿主细胞中有功能的信号序列可与相关蛋白/相关肽/NTP肽基因或cDNA结合使用。因此，该信号序列可与相关蛋白/相关肽/NTP肽基因或cDNA同源或异源，可与相关蛋自/相关肽/NTP肽基因或cDNA同源或异源。另外，此信号序列可用上述方法化学合成。在大部分情况中，通过信号肽的存在宿主细胞分泌多肽时会导致从此多肽中去除氨基末端的甲硫氨酸。

在许多情况中，相关蛋白/相关肽/NTP肽基因或cDNA的转录，可通过载体中存在一个或多个内含子而增加；当相关蛋白、相关肽或NTP肽在真核宿主细胞中产具体是哺乳动物宿主细胞生时尤其如此。所用内含子可以是相关蛋白/相关肽/NTP肽基因中天然存在的，特别是当所用基因是全长基因组序列或其片段时。当基因中无天然产生的此内含子时(对于大部分cDNAs如此)，该内含子可获自另外的来源。由于此内含子必须转录有效，关于其侧翼序列和相关蛋白/相关肽/NTP肽基因的相对位置通常很重要。同样，当插入表达载体中的相关蛋白/相关肽/NTP肽基因是cDNA分子时，该内含子的优选位置是转录起始位点的3’端和聚A转录终止序列的5’端。对于相关蛋白/相关肽/NTP肽cDNA，此内含子或这些内含子优选位于cDNA一侧或另一侧(即5’或3’)，从而不会打断此编码序列。只要此内含子与其插入的宿主细胞相容，任何来源的任何内含子均可用于实施本发明，包括病毒、原核和真核(植物或动物)生物的内含子。还包括在本文中的合成内含子。任选地，在载体中可使用一个以上的内含子。

当上述一个或多个元件不存在于待使用的载体中时，它们可单独获得并连接入载体。用于获得各元件的方法是本领域技术人员熟知的，且可与上述方法相比较(即合成DNA、文库筛选等)。

用于实施本发明的最终载体可从起始载体构建，如商业购买的载体。这种载体可以或可不包含一些完整载体中所含的元件。如果起始载体中没有所需元件，各元件可单独连接入载体，通过用合适的限制性内切酶切割载体，使此元件待连接末端和载体末端适合于连接。在一些情况中，可能必须使待连接在一起的末端成为“平端”，以获得满意的连接。通过先用Klenow DNA聚合酶或T4DNA聚合酶在所有四种核苷酸存在时填补“粘端”来获得平端。此过程是本领域熟知，其描述见例如Sambrook等，同上。另外，待插入此载体的两个或多个元件可先连接一起(如果它们的位置彼此相邻)，随后连接入载体。

另一种构建此载体的方法是在一种反应混合物中同时进行多种元件的所有连接。这里，由于不适当的连接或插入元件将含产生许多无意义和无功能的载体。然而可通过限制性内切酶消化来鉴定和选择功能性载体。

实施本发明的优选载体是与细菌、昆虫和哺乳动物宿主细胞相容的那些载体。这种载体包括pCRII、pCR3和pcDNA3.1(Invitrogen Company，San Diego，Calif.)、pBSII(Stratagene Company，La Jolla，Calif.)、pET15b(Novagen，Madison，Wis.)、PGEX(Pharmacia Biotech，Piscataway，N.J.)、pEGFP-N2(Clontech，Palo Alto，Calif.)、pETL(BlueBacII；Invitrogen)和pFastBacDual(Gibco/BRL，Grand Island，N.Y.)。

在载体构建和编码全长或截短的相关蛋白、相关肽或NTP肽的核酸分子插入此载体的适当位点后，可将此完整的载体插入合适的宿主细胞用于扩增和/或多肽表达。宿主细胞可以是原核宿主细胞(如大肠杆菌)或真核宿主细胞(如酵母细胞、昆虫细胞或脊椎动物细胞)。当宿主细胞在合适条件下培养时，可合成相关蛋白、相关肽或NTP肽，随后从培养基收集(如果宿主细胞分泌它们到培养基中)或直接从产生它们的宿主细胞(如果它不被分泌)收集。

收集后，相关蛋白、相关肽或NTP肽可用分子筛层析、亲和层析等方法纯化。产生相关蛋白、相关肽或NTP肽的宿主细胞的选择部分取决于相关蛋白、相关肽或NTP肽是否糖基化或磷酸化(其中真核宿主细胞优选)、宿主细胞是否能折叠此蛋白质成其天然三级结构(如二硫桥的正确取向等)方式，从而通过具有生物活性的相关蛋白、相关肽或NTP肽而制备生物活性蛋白质。合成后可用下面讨论的合适化学条件折叠相关蛋白、相关肽或NTP肽。用于本发明的合适细胞或细胞系包括哺乳动物细胞，如中国仓鼠卵巢细胞(CHO)、人胚胎肾(HEK)293或293T细胞，或3T3细胞。选择合适的哺乳动物宿主细胞和转化、培养、扩增、筛选和产物生成及纯化的方法是本领域技术人员已知的。其它合适的哺乳动物细胞系包括猴COS-1和COS-7细胞系及CV-1细胞系。更具示范性的哺乳动物宿主细胞包括灵长类细胞系和啮齿动物细胞系，含转化的细胞系。正常二倍体细胞、衍生自原代组织体外培养的细胞株以及原代外植体也是合适的。候选细胞可以是在选择基因中有遗传型缺陷或可含有优势作用的选择基因。其它合适的哺乳动物细胞系包括但不限于小鼠成神经细胞瘤N2A细胞、海拉细胞、小鼠L-929细胞、衍生自Swiss、Balb-c或NIH小鼠的3T3系、BHK或HaK仓鼠细胞系。

与适合于本发明的宿主细胞同样有用的是细菌细胞。例如，多种大肠杆菌菌株(如HB101、DH5α、DH10和MC1061)是生物技术领域中熟知的宿主细胞。枯草芽孢杆菌(B.subtilis)、假单胞菌属(Pseudomonas spp.)、其它芽孢杆菌属(Bacillusspp.)、链霉菌属(Streptomyces spp.)等多种菌株可用于此方法。本领域技术人员已知的许多酵母细胞菌株也可作为表达本发明多肽的宿主细胞。

另外，需要时昆虫细胞系统可用于本发明的方法。这种系统已有描述，例如Kitts等(Biotechniques，14：810-817[1993])、Lucklow(Curr.Opin.Biotechnol.，4：564-572[1993])和Lucklow等(J.Virol.，67：4566-4579[1993])。优选的昆虫细胞是Sf-9和Hi5(Invitrogen，Carlsbad，Calif.)。

插入(也称为转化或转染)载体到所选宿主细胞中可用方法如氯化钙、电穿孔、显微注射、脂转染或DEAE-葡聚糖方法来完成。选择的方法部分利用所用类型宿主细胞的功能。这些方法和其它合适方法是本领域技术人员熟知的并被列出，例如见Sambrook等，同上。

含此载体(即转化的或转染的)的宿主细胞可用本领域技术人员熟知的标准培养基培养。此培养基通常含有细胞生长和存活必需的所有营养物。培养大肠杆菌细胞的合适培养基是例如Luria Broth(LB)和/或Terrific Broth(TB)。培养真核细胞的合适培养基是RPMI1640、MEM、DMEM，它们都添加有血清和/或培养特定细胞系所需的生长因子。培养昆虫的合适培养基是Grace培养基，添加有必需的yeastolate、乳白蛋白水解产物和/或胎牛血清。通常，培养基中加入抗生素或其它仅用于选择性生长转化细胞的化合物作为添加物。所用化合物将通过由转化宿主细胞的质粒上存在的可选择标记元件决定。例如，当可选择标记元件是卡那霉素抗性时，加入培养基的化合物是卡那霉素。

宿主细胞中产生的相关蛋白、相关肽或NTP肽的量可用本领域已知的标准方法评估。这种方法包括但不限于蛋白质印迹分析、SDS-聚丙烯酰胺凝胶电泳、非变性凝胶电泳、HPLC分离、质谱、免疫沉淀和/或活性试验如DNA结合凝胶移位试验。

如果相关蛋白、相关肽或NTP肽设计为从宿主细胞中分泌，大部分相关蛋白、相关肽或NTP肽可发现于细胞培养基中。以此方法制备的蛋白质通常不具有氨基末端甲硫氨酸，因为它在细胞分泌时被去除。然而如果相关蛋白、相关肽或NTP肽不从宿主细胞中分泌，它将存在于细胞质和/或核中(真核宿主细胞)或细胞溶质中(革兰阴性菌宿主细胞)，且可具有氨基末端甲硫氨酸。

对位于宿主细胞细胞质和/或核中的相关蛋白、相关肽或NTP肽，通常先机械破碎宿主细胞或用洗涤剂释放胞内成分到缓冲溶液中。然后可从溶液中分离相关蛋白、相关肽或NTP肽。

从溶液中纯化相关蛋白、相关肽或NTP肽可采用多种技术完成。如果合成的蛋白质含有如6个组氨酸的钯(NTP蛋白/hexa His)或其它小肽如FLAG(Sigma-Aldritch，St.Louis，MI)或在其羧基或氨基末端含有钙调蛋白-结合肽(Stratagene，LaJolla，CA)，它可采用一步法使溶液通过亲和柱来纯化，柱中的柱基质对该尾巴或直接对该蛋白质有高亲和性(即特异性识别相关蛋白或相关肽的单克隆抗体)。例如，聚组氨酸能以高亲和力特异性结合镍、锌及钴；因而使用以镍为基础的亲和树脂(如Qiagen的QIAexpress system或Invitrogen的Xpress System中所用的)或以钴为基础的亲和树脂(如BD Biosciences-CLONTECH的Talon system中所用的)的固定金属离子亲和层析可用于纯化NTP相关蛋白/聚组氨酸。(参见例如，Ausubel等编，《新编分子生物学实验指南》，10.11.8章节，John Wiley&Sons，纽约[1993])。

当制备的相关蛋白、相关肽或NTP肽没有附着尾巴又不能得到其抗体时，可使用其它熟知的纯化方法。这种方法包括但不限于离子交换层析、羟基磷灰石层析、疏水作用层析、分子筛层析、HPLC、结合凝胶洗提的天然凝胶电泳以及制备型等电聚焦(Isoprime机器/技术，Hoefer Scientific)。在一些情况下可联合一种或多种技术以提高纯度。

如果预期相关蛋白、相关肽或NTP肽主要发现于胞内，可用本领域技术人员已知的标准技术提取宿主细胞中的胞内物质(包括革兰阴性菌的包含体)。例如可离心后通过弗氏压碎器、匀浆和/或超声裂解宿主细胞以释放周质/细胞质成分。如果相关蛋白、相关肽或NTP肽在细胞溶质中形成包含体，该包含体常结合于内和/或外细胞膜，因此离心后主要见于沉淀物中。然后在存在还原剂如碱性pH的二硫苏糖醇或酸性pH的三羧乙基膦时用极端pH或用离液剂如去污剂、胍、胍衍生物、尿素或尿素衍生物处理此沉淀物以释放、破裂和溶解此包含体。然后可对已是可溶形式的相关蛋白、相关肽或NTP肽用凝胶电泳、免疫沉淀等分析。如果需要分离相关蛋白、相关肽或NTP肽，可用标准方法完成分离，如下面和Marston等(Meth.Enz.，182：264-275[1990])列出的方法。

在一些情况中，相关蛋白、相关肽或NTP肽分离时可能没有生物活性。可采用重折叠或转变此多肽成其三级结构并产生二硫键的多种方法恢复其生物活性。这些方法包括使溶解的多肽暴露于通常高于7的pH和存在的特定浓度离液剂。离液剂的选择非常类似于用于包含体溶解的选择，但通常浓度较低且不一定是溶解所用的同一离液剂。在大部分情况中，重折叠/氧化溶液也包含还原剂或特定比例的还原剂加其氧化形式，以产生特定氧化还原电势使二硫化物改组形成蛋白质的半胱氨酸桥。一些常用的氧化还原对包括半胱氨酸/胱胺、谷胱甘肽(GSH)/二硫双GSH(dithiobis GSH)、氯化铜、二硫苏糖醇(DTT)/二噻烷DTT、2-巯基乙醇(bME)/二硫-b(ME)。在许多情况中，需要共溶剂以提高重折叠的效率，用于此目的较常用试剂包括甘油、不同分子量的聚乙二醇和精氨酸。

如果宿主细胞中不形成显著程度的相关蛋白、相关肽或NTP肽包含体，细胞匀浆离心后相关蛋白、相关肽或NTP肽主要见于上清液中，相关蛋白、相关肽或NTP肽可用如下方法从上清液中分离获得。

当优选部分或完全分离相关蛋白、相关肽或NTP肽的情况中，可用本领域技术人员熟知的标准方法完成纯化。这种方法包括但不限于电泳分离，接着电洗脱、多种类型的层析(免疫亲和、分子筛和/或离子交换)、和/或高压液相层析。在一些情况中，优选使用一种以上的这些方法来完全纯化。

除了用重组DNA技术制备和纯化相关蛋白、相关肽或NTP肽外，相关蛋白、相关肽或NTP肽和它们的片段、变体、同源物和衍生物可用化学合成方法制备(如固相肽合成)，使用本领域已知技术如描述于Merrifield等，(J.Am.Chem.Soc.，85：2149[1963])、Houghten等(Proc.Natl.Acad.Sci.USA，85：5132[1985])、Stewart和Young(《固相肽合成》(Solid Phase Peptide Synthesis)，Pierce Chemical Co.，Rockford，III.[1984])。可合成氨基末端有或没有甲硫氨酸的这些多肽。化学合成的相关蛋白、相关肽或NTP肽可用参考文献所列方法氧化以形成二硫桥。预期相关蛋白、相关肽或NTP肽具有相当于重组产生或纯化自天然来源的相关蛋白、相关肽或NTP肽相的生物活性，因此可与重组或天然的相关蛋白、相关肽或NTP肽交换使用。

化学修饰的相关蛋白、相关肽或NTP肽组合物中包含连接于一聚合物的相关蛋白、相关肽或NTP肽属于本发明范围内。所选聚合物通常可溶于水从而其结合的蛋白质在水环境，如生理环境中不会沉淀。所选聚合物通常经修饰而具有一个反应基团如用于酰化的活性酯或用于烷化的醛，这样可如本方法所提供的那样，控制聚合程度。聚合物可以是任何分子量，可以分支或不分支。相关蛋白/相关肽/NTP肽聚合物范围包括聚合物的混合物。

在一些情况中，需要制备天然产生的相关蛋白、相关肽或NTP肽的核酸和/或氨基酸变体。核酸变体可用定点诱变、PCR扩增或其它合适方法产生，其中引物具有所需的点突变(诱变技术的描述参见Sambrook等，同上，Ausubel等，同上)。采用Engels等(同上)，所述的化学合成方法也可制备这种变体。其它本领域技术人员已知的方法也可使用。

优选的核酸变体是用于产生相关蛋白、相关肽或NTP肽的宿主细胞中含有密码子优先的核苷酸取代的那些变体。这种“密码子最优化”可通过计算机算法确定，此算法结合密码子频率表如“Ecohigh.Cod”作为高表达细菌基因的密码子优先，由University of Wisconsin包版本9.0，遗传学计算机组，Madison，Wis提供。其它有用的密码子频率表包括“Celegans_high.cod”、“Celegans_low.cod”、“Drosophila_high.cod”、“Human_high.cod”、“Maize_high.cod”和“Yeast_high.cod”。其它优选变体是编码上述与野生型相比保守性氨基酸变化(如其中天然产生的氨基酸侧链的电荷或极性没有因被不同氨基酸取代而显著改变)的变体、和/或设计为产生新的糖基化和/或磷酸化位点的变体、或设计为缺失现有糖基化和/或磷酸化位点的变体。

相关蛋白、相关肽、NTP肽、其片断、同源物、变体、衍生物及其盐类可用此领域的普通技术人员已知的常规肽合成技术产生。这些技术包括化学偶联方法(参见Wunch，E：“有机化学方法”，第15卷，Band 1+2，Synthese von Peptiden，thimeVerlag，Stuttgart(1974)和Barrany，G.；Marrifield，R.B.：“肽”(The Peptides)，E.Gross，J.Meienhofer编，第2卷，第1章，1-284页，Academic Press(1980))、酶偶联方法(参见Widmer，F.Johansen，J.T.，Carlsverg Res.Commun.，第44卷，37-46页(1979)和Kullmann，W.：“酶促性肽合成”(Enzymatic Peptide Synthesis)，CRC Press Inc.BocaRaton，Fla.(1987)和Widmer，F.，Johansen，J.T.，“生物和医学中的合成肽”(SyntheticPeptides in Biology and Medicines)，Alitalo，K.，Partanen，P.，Vatieri，A.编，79-86页，Elsevier，Amsterdam(1985))、或化学和酶方法的组合，如果这具有加工设计和经济的优点。使用本文提供的指南，本领域技术人员能改变相关蛋白、相关肽或NTP肽的肽序列以产生具有与原始或天然相关蛋白、相关肽或NTP肽相同或类似生物活性的同源物。

采用给定的相关蛋白、相关肽或NTP肽的模拟物而不是此蛋白质本身有其优点。通常，与该蛋白质和肽相比，肽模拟物的生物利用度更高，具有较长的作用时间且生产成本较低。

因此，上述相关蛋白、相关肽和NTP肽可用于开发具有类似生物活性从而具有类似治疗作用的小化学化合物。可采用组合化学技术和本领域已知的其它技术开发相关蛋白、相关肽和NTP肽的肽模拟物(参见例如《第20届欧洲肽专题讨论会论文集》(Proceedings of the 20th European Peptide Symposium)，G.Jung，E.Bayer编，289-336页，和其中的参考文献)。

结构上修饰本领域已知的肽以产生肽模拟物的方法的例子包括倒置主链手性中心产生D-氨基酸残基结构，具体是在N-末端，导致对蛋白酶降解的稳定性提高而对活性没有不利影响。在论文“含氚D-丙氨酸¹-肽T结合”，Smith C.S.等，DrugDevelopment Res.，15，371-379页(1988)中给出了一个例子。

第二种方法是改变稳定性所需的环状结构，如N到C链间的二酰亚胺和内酰胺(Ede等，Smith和Rivier编，《肽：化学和生物学》，Escom，Leiden，1991，268-270页)。例子见构型限制的胸腺五肽样化合物，如美国专利号4,457,489(1985)，Goldstein，G.等所公开的那样，其内容全部纳入本文供参考。

第三种方法是用能赋予蛋白水解抗性的假肽键替换相关蛋白、相关肽或NTP肽中的肽键。已报道了一些假肽键一般不影响肽的结构和生物活性。此方法的一个例子是取代逆一反假肽键(“胸腺五肽的生物活性逆反转同源物”，Sisto A等，Rivier，J.E.和Marshall，G.R.编，“肽、化学、结构和生物学”，Escom，Leiden，1990，722-773页)和Dalpozzo等(1993)，Int.J.Peptide Protein Res.，41：561-566，纳入本文供参考)。根据此修饰，此肽的氨基酸序列可能与上述相关蛋白、相关肽和NTP肽的序列相同，除了一个或多个肽键被逆反转假肽键所取代外。优选大部分N-末端肽键被取代，由于这种取代将赋予对外肽酶作用于N-末端水解蛋白的抗性。

合成具有一个或多个还原的逆反转假肽键的肽是本领域已知的(Sisto(1990)和Dalpozzo等，(1993)，见上)。因此肽键可用非肽键替代使肽模拟物获得与原始肽相似的结构，从而生物活性相似。也可用其它类似结构的化学基团替代氨基酸的化学基团作进一步修饰。另一种已知可提高对酶裂解的稳定性而生物活性没有或很少损失的合适假肽键，是还原型电子等排物假肽键(Couder等(1993)，Int.J.PeptideProtein Res.，41：181-184，全部纳入本文供参考)。因此，这些肽的氨基酸序列可能与相关蛋白、相关肽或NTP肽序列相同，除了一个或多个肽键被电子等排物假肽键替代外。优选大部分N-末端肽键被取代，由于这种取代将赋予对外肽酶作用于N-末端水解蛋白的抗性。合成具有一个或多个还原型电子等排假肽键的肽是本领域已知的(Couder等1993，见上)。其他例子包括导入酮亚甲基键或甲硫键来替代肽键。

相关蛋白、相关肽和NTP肽的拟肽衍生物代表了另一类肽模拟物，拟肽保留了生物活性的重要结构决定簇，但去除了肽键，可赋予对蛋白水解的抗性(Simon等，1992，Proc.Natl.Acad.Sci.USA，89：9367-9371，全部纳入本文供参考)。拟肽是N-取代的甘氨酸的寡聚物。已报道了一些N-烷基基团，各对应于天然氨基酸的侧链(Simon等，1992，见上)。相关蛋白、相关肽或NTP肽的一些或所有氨基酸用对应于所替代氨基酸的N-取代甘氨酸替代。

可通过NMR谱、晶体图和/或计算机-辅助分子模型确定原始相关蛋白、相关肽或NTP肽的三级结构来协助开发肽模拟物。这些技术可帮助开发具有比原始肽更高效力和/或更高生物利用率和/或更高稳定性的新组合物(Dean(1994)，BioEssays，16：683-687；Cohen和Shatzmiller(1993)，J.Mol.Graph.，11：166-173；Wiley和Rich(1993)，Med.Res.Rev.，13：327-384；Moore(1994)，Trends Pharmacol.Sci.，15：124-129；Hruby(1993)，Biopolymers.，33：1073-1082；Bugg等(1993)Sci.Am.，269：92-98，全部纳入本文供参考)。

一旦一种潜在的肽模拟物化合物被鉴定，它可以用下面例子中列出的方法合成和分析以评估其活性。用上述方法获得的肽模拟化合物包括在本发明范围内，该化合物具有相关蛋白、相关肽或NTP肽的生物活性和类似的三维结构。本领域技术人员不难明白，此肽模拟物可从任何携带上述一种或多种修饰的相关蛋白、相关肽或NTP肽中产生。还将明白，本发明的肽模拟物除了其作为治疗化合物的用途外，可进一步用于开发甚至更强的非肽化合物。

今天许多机构都能够合成本文所述的相关蛋白、相关肽和NTP肽。例如，有了一种NTP肽的序列，这些机构就能合成肽并为合成的肽提供相应的文件并证明肽的相同性。

本发明还包括使用相关蛋白、相关肽和NTP肽和它们相应的核酸分子进行试验，以定性或定量测定哺乳动物组织或体液样品中相关蛋白、相关肽、NTP肽、相关蛋白/相关肽/NTP肽的DNA或相应RNA的存在。相关蛋白、相关肽、NTP肽和它们相应的核酸分子可用于这些试验的准备，无论相关蛋白、相关肽或NTP肽或者编码的相关蛋白、相关肽或NTP肽是否显示生物活性。相关蛋白、相关肽或NTP肽的核酸序列可能是杂交探针有用的来源以定性或定量测定哺乳动物组织或体液样品中相关蛋白、相关肽或NTP肽DNA或相应RNA的存在。

本身不具生物活性的相关蛋白、相关肽或NTP肽可用于制备识别和/或结合相关蛋白、相关肽或NTP肽的抗体。这种抗体可用标准方法制备。因此，与相关蛋白、相关肽或NTP肽反应的抗体以及短链抗体片段和这种抗体的其它反应片段也在本发明范围内。抗体可以是多克隆、单克隆、重组、嵌合、单链和/或双特异性。通常，抗体或其片段是人来源或“人源化”，即制备后给予病人时可防止对抗体的免疫反应或减少到最低程度。优选的抗体是人抗体，多克隆或单克隆。抗体片段可以是能与本发明相关蛋白、相关肽或NTP肽反应的任何片断，如F_ab、F_ab’等。本发明还提供了杂交瘤，方法是通过呈递作为抗源的相关蛋白、相关肽或NTP肽给所选哺乳动物，接着用已知技术使该哺乳动物的细胞(如脾细胞)与一些癌细胞融合以产生无限增殖的细胞系。本发明还包括产生这种细胞系和产生抗所有或部分相关蛋白、相关肽或NTP肽的抗体的方法。

此种抗体可进一步用于体内和体外诊断或研究目的，如以标记形式来检测体液或细胞样品中相关蛋白、相关肽或NTP肽的存在。

本发明还包括使用一种或多种相关蛋白、相关肽或NTP肽作为试验中的校准标准品，以定性或定量测定哺乳动物组织或体液样品中相关蛋白、相关肽、NTP肽、相关蛋白/相关肽/NTP肽的DNA或相应RNA的存在。

本发明涉及治疗需要除去细胞的疾病的新方法，如良性或恶性肿瘤、腺体(如前列腺)增生、不想要的面部汗毛、疣和不想要的脂肪组织。这种方法包括将治疗有效量的相关蛋白、相关肽或NTP肽给予需要的哺乳动物。

这类疾病可以是例如肺、乳房、胃、胰、前列腺、膀胱、骨、卵巢、皮肤、肾、窦、结肠、肠、胃、直肠、食道、血液、大脑和其覆盖物、脊髓和其覆盖物、肌肉、结缔组织、肾上腺、副甲状腺、甲状腺、子宫、睾丸、垂体、生殖器、肝脏、胆囊、眼、耳、鼻、喉、扁桃腺、口、淋巴结和淋巴系统及其它器官的肿瘤。

如本文所用，术语“恶性肿瘤”包括人类癌、肉瘤和黑素瘤的所有形式，它们以低度分化、适度分化、高度分化的形式出现。

本发明满足本领域治疗的需要，可以除去良性肿瘤而风险较小、不良的手术副作用较少。特别需要在手术危险区如体内深处位(例如脑、心脏、肺和其它)去除良性肿瘤的方法。

治疗必须除去细胞的疾病的方法可与治疗这些疾病的常规方法如手术切除、化疗和放射治疗结合使用。相关蛋白、相关肽或NTP肽可在这些常规治疗之前、期间或之后施用。

待治疗的疾病也可以是选自肺、乳房、胃、胰、前列腺、膀胱、骨、卵巢、皮肤、肾、窦、结肠、肠、胃、直肠、食道、血液、大脑和其覆盖物、脊髓和其覆盖物、肌肉、结缔组织、肾上腺、副甲状腺、甲状腺、子宫、睾丸、垂体、生殖器、肝脏、胆囊、眼、耳、鼻、喉、扁桃腺、口、淋巴结和淋巴系统的组织增生，肥大或过度生长。

可用本发明方法治疗的其它疾病是选自肺、乳房、胃、胰、前列腺、膀胱、骨、卵巢、皮肤、肾、窦、结肠、肠、胃、直肠、食道、血液、大脑和其覆盖物、脊髓和其覆盖物、肌肉、结缔组织、肾上腺、副甲状腺、甲状腺、子宫、睾丸、垂体、生殖器、肝脏、胆囊、眼、耳、鼻、喉、扁桃腺、口、淋巴结和淋巴系统的病毒，细菌或寄生虫改变的组织。

待治疗的疾病也可以是选自肺、乳房、胃、胰、前列腺、膀胱、骨、卵巢、皮肤、肾、窦、结肠、肠、胃、直肠、食道、血液、大脑和其覆盖物、脊髓和其覆盖物、肌肉、结缔组织、肾上腺、副甲状腺、甲状腺、子宫、睾丸、垂体、生殖器、肝脏、胆囊、眼、耳、鼻、喉、扁桃腺、口、淋巴结和淋巴系统的组织畸形或乱。

具体说，待治疗的疾病可以是扁桃体肥大、前列腺增生银屑病、湿疹、皮肤病或痔。待治疗的疾病可以是血管病如动脉粥样硬化或动脉硬化，或者是血管病如静脉曲张。待治疗的疾病也可以是以下组织的整容修饰，如皮肤、眼、耳、鼻、喉、口、肌肉、结缔组织、毛发或乳房组织。

相关蛋白、相关肽和/或NTP肽的治疗性组合物属于本发明范围内。这种组合物可包括治疗有效量的相关蛋白、相关肽或NTP肽与药学上可接受载体的混合物。载体物质可以是注射用水，优选在溶液中添加哺乳动物给药常用的其它物质。通常，用于治疗的相关蛋白、相关肽或NTP肽以组合物形式给药，该组合物包括纯化的相关蛋白、相关肽或NTP肽，加上一种或多种生理上可接受的载体、赋形剂或稀释剂。中性缓冲盐水或与血清白蛋白混合的盐水是适当载体的范例。优选此产物用合适的赋形剂(如蔗糖)制成冻干物。如果需要可包括其它标准载体、稀释剂和赋形剂。组合物包括此领域普通技术人员已知的pH值范围合适的缓冲液，包括pH7.0-8.5的Tris缓冲液、或pH 4.0-5.5的乙酸缓冲液，此缓冲液还可包括山梨醇或其合适的替代物。

对于靶向不想要的细胞成分的相关蛋白、相关肽或NTP肽偶联的或连接或结合的抗体、抗体片段、抗体样分子或对特异性肿瘤标记如细胞受体、信号肽或过度表达的酶有高亲和性的分子，也在发明范围内。这些抗体、抗体片段、抗体样分子或对特异性肿瘤标记有高亲和性的分子，可用于将所述相关蛋白、相关肽或NTP肽偶联物到特定细胞或靶组织。例如，具有特殊表面抗原或表达抗原的肿瘤可被这些抗体、抗体片段、抗体样结合分子靶向，因而肿瘤细胞可被相关蛋白、相关肽或NTP肽所杀死。这种采用抗体靶向的方法优点是降低剂量、增加结合和被靶细胞摄取的可能性、提高靶向和治疗转移性肿瘤和微小肿瘤的效率。

本发明还包括采用偶联于或连接或结合于蛋白质或其它分子的所述相关蛋白、相关肽和NTP肽以形成组合物，通过肿瘤-特异性或位点-特异性酶或蛋白酶或者通过靶向肿瘤或其它不想要的细胞的抗体偶联物，在肿瘤或其它不想要的细胞部位或附近裂解时，在肿瘤或其它不想要的细胞的部位或附近释放相关蛋白、相关肽或NTP肽。

本发明还包括采用偶联于或连接或结合于蛋白质或其它分子的所述相关蛋白、相关肽和NTP肽以形成组合物，在待治疗组织暴露于光(如激光疗法或其它光动力学或光活化疗法)、其它形式电磁辐射时，该组合物可释放相关蛋白、相关肽或NTP肽或相关蛋白、相关肽或NTP肽的一些生物活性片段，电磁辐射的其它形式有例如红外线辐射、紫外线辐射、x射线或γ射线辐射、局部加热、α或β辐射、超声波发射或其它局部能量源。

相关蛋白、相关肽或NTP肽可单独、一起或联合其它药物组合物使用，如对待治疗指征合适的细胞因子、生长因子、抗生素、细胞凋亡诱导剂、抗炎药物和/或化疗剂。

本发明还包括所述蛋白、相关肽或NTP肽的组合物，此组合物采用树状聚体、富勒烯和其它合成分子、聚合物及大分子，组合物中相关蛋白、相关肽或NTP肽和/或其相应DNA分子本身或与其它种类分子如肿瘤特异性标记偶联、结合于或包裹在上述分子、聚合物或大分子中。例如，美国专利号5,714,166《生物活性和/或靶树状聚体结合物》(Bioactive and/or Targeted Dendrimer Conjugates)提供了制备和利用靶树状聚合偶联物的方法，此种偶联物包括至少一种树状聚体和靶指示物以及至少一种与之偶联的生物活性剂剂。

本发明还包括所述相关蛋白、相关肽或NTP肽和/或基因及药物递送载体的治疗性组合物，递送载体有例如脂质乳剂、胶束聚合物、聚合物微球、电活化聚合物、水凝胶和脂质体。

采用可转运到不想要细胞的相关蛋白、相关肽或NTP肽或相关基因或基因同等物也在本发明范围内。肿瘤内过度表达所述相关蛋白、相关肽或NTP肽可用于诱导肿瘤中的细胞死亡并因而减少肿瘤细胞群。采用能转运所述相关蛋白、相关肽或NTP肽以治疗不想要的细胞成分的基因或基因同等物，其优点是所需剂量更少、可通过靶细胞分子的细胞后代传代，治疗次数必然减少、总体治疗减少。本发明还包括将编码含相关蛋白、相关肽或NTP肽的融合蛋白的基因转运给不想要的细胞或其邻近细胞，表达该基因及产生和/或分泌此融合蛋白后，此融合蛋白受到天然酶或蛋白酶或者前体药物的切割可释放出所述相关蛋白、相关肽或NTP肽到不想要的细胞或附近。

应用克隆的重组相关蛋白-、相关肽-或NTP肽-抗体偶联物；克隆的重组相关蛋白、、相关肽、或NTP肽-抗体片段偶联物；克隆的重组相关蛋白-、相关肽-或NTP肽-抗体样蛋白偶联物也包括在本发明范围内。与寻靶偶联物(如抗体、抗体片段、抗体样分子或者对癌特异性受体或其它肿瘤标记有高亲和性的分子)结合的克隆的所述相关蛋白、相关肽或NTP肽的优点，是这种分子兼有上述寻靶优点，及可制造和标准化生产克隆的偶联分子的优点。

口服给药的固体剂量形式包括但不限于胶囊、片剂、药丸、粉末和颗粒。在这种固体剂量形式中，优选将活性化合物与至少一种下列物质混合：(a)一种或多种惰性赋形剂(或载体)，如柠檬酸钠或磷酸二钙；(b)填充剂或膨胀剂，如淀粉、乳糖、蔗糖、葡萄糖、甘露醇和硅酸；(c)粘合剂，如羧甲基纤维素、藻酸盐、明胶、聚乙烯吡咯烷酮、蔗糖和阿拉伯树胶；(d)保湿剂，如甘油；(e)崩解剂，如琼脂-琼脂、碳酸钙、马铃薯或木薯淀粉、褐藻酸、一些复合硅酸盐和碳酸钠；(f)溶液缓聚剂，如石蜡；(g)吸收加速剂，如季铵化合物；(h)润湿剂，如乙酰醇和甘油单硬脂酸盐；(i)吸收剂，如瓷土和斑脱土；(j)滑润剂，如滑石、硬脂酸钙、硬脂酸镁、固体聚乙二醇、月桂酰硫酸钠和它们的混合物。就胶囊、片剂、药丸而言，其剂量形式也可包括缓冲剂。

口服给药的液体剂量形式包括药学上可接受的乳剂、溶液、悬浮液、糖浆和酏剂。除了活性化合物外，液体剂量形式可包括本领域常用的惰性稀释剂如水或其它溶剂、增溶剂和乳化剂。乳化剂的范例是乙醇、异丙醇、碳酸乙酯、乙酸乙酯、苄醇、苯甲酸苄酯、丙二醇、1，3-丁二醇、二甲基甲酰胺，油如棉子油、花生油、玉米胚芽油、橄榄油、蓖麻油和芝麻油，甘油、四氢糠醇、聚乙二醇、山梨聚糖的脂肪酸酯或这些物质的混合物等。

除了这种惰性稀释剂，该组合物也可包括辅佐剂，如润湿剂、乳化剂和悬浮剂、甜味剂、调味剂和香味剂。

本发明组合物中活性成分的实际剂量水平可以改变以得到治疗有效量的相关蛋白、相关肽或NTP肽从而获得对具体组合物和给药方法的理想治疗反应。因此选择剂量水平取决于所需的治疗效果、给药途径、所需治疗的持续时间以及其它因素。

哺乳动物包括人的有效量可根据体表面积给药。用于不同大小、种类的动物和人的剂量间的相互关系(以体表的mg/M²为基础)的描述见E.J.Freireich等，Cancer Chemother.Rep.，50(4)：219(1966)。体表面积可从个体身高体重大约确定(参见例如《科学表》(Scientific Tables)，Geigy Pharmaceuticals，Ardsley，N.Y.537-538页(1970))。

给予宿主的所述相关蛋白、相关肽或NTP肽的每日总剂量可以是单剂或分开的剂量。剂量单位组合物包含几分之一的量可用于构成每天剂量。然而要理解的是，任何具体病人的特定剂量水平取决于多种因素，包括体重、整体健康、性别、饮食、给药时间和途径、所给药物的效力、吸收和排泄的比例、联用的其它药物以及所治疗具体疾病的严重性。

给予本发明的相关蛋白、相关肽或NTP肽组合物的方法，包括但不限于肌肉内、口服、静脉内、腹膜内、大脑内(实质内)、脑心室内、肿瘤内、病灶内、皮内、鞘内、鼻内、眼内、动脉内、局部、透皮、通过气雾剂、输注、推射、植入装置、缓释系统等。

另一种给予本发明的相关蛋白、相关肽或NTP肽组合物的方法，是经皮或透皮途径。这种实施方案的一个例子是使用贴片。具体是，贴片可用相关蛋白、相关肽或NTP肽的精细悬浮液制备，例如二甲亚砜(DMSO)或DMSO与棉子油的混合物，使其接触携带肿瘤的哺乳动物皮肤，离开皮肤囊(pouch)内肿瘤定位部位。含有其它溶剂和固体支持物的其它介质或其混合物也可同样起作用。此贴片可包含溶液或悬浮液形式的所述相关蛋白、相关肽或NTP肽化合物。然后可将贴片应用于病人皮肤，例如将它插入病人的皮肤囊，此种皮肤囊可通过用缝针、夹子或其它夹持装置折叠皮肤并夹持在一起来形成。应确保囊与皮肤连续接触而不干扰哺乳动物。除了使用皮肤囊，可使用任何能保证牢固放置的贴片与皮肤接触的装置。例如，粘附绷带可用来保持贴片在皮肤上。

所述相关蛋白、相关肽或NTP肽可以缓释制剂或制品给药。缓释制剂的合适例子包括成形物质形式的半透性聚合物基质，如薄膜或微胶囊。缓释基质包括聚酯、水凝胶、聚交酯(美国3,773,919、EP58,481)、L-谷氨酸和γ乙基-L-谷氨酰胺的共聚物(Sidman等，Biopolymers，22：547-556[1983])、聚(2-羟乙基-甲基丙烯酸盐)(Langer等，J.Biomed.Mater.Res.，15：167-277[1981]和Langer等，Chem.Tech.，12：98-105[1982])、乙烯乙酸聚乙烯(Langer等，同上)或聚-D(-)-3-羟基丁酸(EP133,988)。缓释组合物也包括脂质体，可用本领域已知的一些方法之一来制备(如Eppstein等，Proc.Natl.Acad.Sci.USA，82：3688-3692[1985]；EP 36,676；EP 88,046和EP 143,949)。

另一种给予本发明相关蛋白、相关肽或NTP肽的方法，是将相关蛋白、相关肽或NTP肽直接或间接输入到待治疗的肿瘤或其它组织中。这种实施方案的一个例子是直接注射相关蛋白、相关肽或NTP肽到待治疗的肿瘤或其它组织中。此种治疗可以是单次注射、一段时间多次注射或几小时、几天或几个月内一系列注射，待治疗肿瘤或其它组织的消退或破坏可通过活组织检查、摄像或其它监测组织生长的方法来监控。可通过插入孔中如鼻、口、耳、阴道、直肠或尿道中的装置注射到待治疗的肿瘤或其它组织中或穿过切口以到达体内的肿瘤或组织，此种注射可与摄像或光学系统如超声波或纤维光镜结合进行，以确定注射部位是不合适。这种实施方案的另一个例子是采用可使相关蛋白、相关肽或NTP肽恒定输入到该种组织的装置。

又一种给予本发明相关蛋白、相关肽或NTP肽的方法是，与手术或类似的用于物理切除、消融或者杀死或破坏需要去除或破坏的肿瘤或其它组织或细胞成分的方法相结合，其中将本发明的相关蛋白、相关肽或NTP肽给予待去除的肿瘤或其它组织的周围接近区域，以破坏或阻止肿瘤细胞的生长，或此方法不会除去或破坏其它的细胞成分。

另一种给予本发明相关蛋白、相关肽或NTP肽的方法是将装置植入到待治疗的肿瘤或其它组织中。这种实施方案的一个例子是将含相关蛋白、相关肽或NTP肽的薄片植入到待治疗的肿瘤或其它组织中。薄片随时可释放治疗剂量的相关蛋白、相关肽或NTP肽到该组织中。另外，该组合物可局部应用，通过植入吸附了相关蛋白、相关肽或NTP肽的膜、海绵或其它合适物质到受影响的区域。使用植入装置时，此装置可植入到任何合适的组织或器官中，相关蛋白、相关肽或NTP肽的输送可直接通过该装置，经推注或经连续给药或经导管连续输注。

另外一种给药方法是将一个或多个拷贝的相关蛋白-、相关肽-或NTP肽-编码基因导入靶细胞，如果必要，诱导此基因复制开始胞内产生所述相关蛋白、相关肽或NTP肽。一种可用于基因治疗的方式是采用相关蛋白-、相关肽-或NTP肽-编码基因(编码相关蛋白、相关肽或NTP肽(或其片断、变体、同源物或衍生物)的基因组DNA、cDNA和/或合成的DNA)，可特此基因操作性连接于一组成型或可诱导启动子以形成“基因治疗DNA构建物”。只要该启动子在构建物插入的细胞或组织类型中具有活性，它可与内源性相关蛋白-、相关肽-或NTP肽-编码基因同源或异源。如果需要，该基因治疗DNA构建物的其它成分可任选地包括设计用于位点特异性整合的DNA分子(如用于同源重组的内源性侧翼序列)，组织特异性启动子、增强子或沉默子，能提供选择性优于亲代细胞的DNA分子、用作鉴定转化细胞标记的DNA分子、阴性选择系统、细胞特异结合剂(例如用于细胞靶向)、细胞特异性内化因子、提高载体表达的转录因子以及能使载体生产的因子。

体内或活体外输送基因到细胞或组织中的方法，包括(但不限于)直接注射裸露DNA、弹道方法、脂质体介导的转运、受体介导的转运(配体-DNA复合体)、电穿孔和磷酸钙沉淀，参见美国专利号4,970,154、WO 96/40958、美国专利号5,679,559、美国专利号5,676,954和美国专利号5,593,875，其公开的内容全部纳入本文供参考。

相关蛋白-、相关肽-或NTP肽-编码基因可通过植入患者的某些细胞中来输送，患者的这种细胞已用本文所述方法在活体外进行了遗传工程改造能表达和分泌所述相关蛋白、相关肽或NTP肽或其片段、变体、同源物或衍生物。这种细胞可以是动物或人细胞，可获自病人自身组织或另外的人或非人来源。任选地此种细胞可以是无限增殖的细胞或可以是干细胞。然而为减少免疫应答的机会，优选包裹这种细胞以防止向周围组织渗透。包裹物质一般是生物相容的半透性聚合性封闭物或膜，能使蛋白产物释放但可阻止病人免疫系统细胞或周围组织的其它有害因素的破坏。用于膜包裹细胞的方法是该领域技术人员所熟悉的，可制备包裹的细胞并植入到病人中而不需要过多的实验。参见例如美国专利号4,892,538；5,001,472和5,106,627，它们公布的内容全部纳入本文供参考。包裹活细胞的系统描述见PCTWO 91/10425。制备多种其它持续或受控制递送方式的技术是本领域技术人员已知的，如脂质体载体、生物可侵蚀的颗粒或珠，这些技术描述见例如美国专利号5,653,975，其公开的内容全部纳入本文供参考。可装包裹或不包裹的细胞植入到病人的适当机体组织或器官中。

* * * *

提供以下实施例以阐明本发明。然而应理解本发明不限于这些实施例中所述的具体条件和细节。在本说明书中，任何和所有公众可得到的文献纳入供参考，包括美国专利。

特别地，本发明特意包括了待审批美国专利申请序列号10/092,934：“用神经丝状蛋白治疗肿瘤和相关疾病的方法”中列出的实施例以供参考，此文显示完整的AD7c-NTP蛋白是在体外胶质瘤和成神经细胞瘤细胞培养物中以及体内正常啮齿动物肌肉组织、皮下结缔组织和真皮中，以及多种不同人和非人来源的肿瘤(包括乳腺癌、皮肤癌和乳头状瘤、结肠癌、脑胶质瘤和啮齿动物模型中的其它肿瘤)中造成细胞死亡的一种有效制剂。本发明还特意包括了待审批美国专利申请序列号10/153,334的实施例以供参考，该文显示NTP肽是在体内正常啮齿动物肌肉组织、皮下结缔组织、真皮和其它组织中造成细胞死亡的有效制剂。

实施例1

此实施例的目的是测定NTP肽#6对注射部位组织的作用。

用乙醚将雄性Sprague-Dawley大鼠(体重范围300克)麻醉，并在外科手术暴露前列腺后通过前列腺内灌输给予NTP肽#6。注射剂包括300μlNTP肽#6、1mg/mLPBS pH 7.4(1.0mg/kg)(n＝8)，对照仅注射PBS(n＝6)，并有未注射对照(n＝2)。72小时后无痛处死动物。解剖前列腺，将其在10％的缓冲福尔马林中固定24小时，石蜡包埋，切片并用H&E染色。将每个动物的完整前列腺包埋并切片。所有染色切片进行组织学检测并进行测量。每个前列腺至少检测4张组织切片，测量每张组织切片相互垂直(90。)的两个截面的直径(每个前列腺总共测量8次或以上)。用每个前列腺这些测量值的平均直径，根据公式

V = \frac{4}{3} {(\frac{D}{2})}^{3}

估算体积。

结果：与对照(仅注射PBS的对照和未注射的对照没有可以觉察的变化)相比，注射了NTP肽#6的大鼠前列腺体积减小估计平均为45％。经过处理的大鼠前列腺显示腺上皮广泛丧失、扁平和萎缩。溶于PBS(pH7.4)的NTP肽#6通常以1.0mg/kg灌输到大鼠前列腺，在72小时时，与未处理或PBS处理的对照相比，估计前列腺体积减小40％以上。

实施例2

此实施例的目的是测定NTP肽#7对注射部位组织的作用。

给4只正常大鼠作皮内和皮下注射，各注射四个不同的点，四肢骨骼肌注射时，各注射两个不同的点，通过不锈钢26号针头从塑料注射器输注0.1-1mg/ml浓度的100-400ml盐水配的NTP肽#7。

观察动物24小时且在24小时后无痛处死动物。切取各渗透灶，固定在10％福尔马林中，石蜡包埋，染色并用标准组织病理学方法检测。

对照仅接受盐水注射。

结果：注射NTP肽#7后注射部位产生急性组织坏死。坏死在NTP肽#7注射部位的肌肉组织、皮下结缔组织和真皮中明显。坏死与注射区域相关连，似乎不扩散到离注射部分很远。

远离炎症的轻度区域，对照没有显示出坏死或细胞损失。对照显示出极少或没有肌肉变化。对照注射在注射部位有轻度至极小的急性炎症及针头引起的灶性微出血。

实施例3

此实施例的目的是测定相关肽#1对注射部位组织的作用。

如上述实施例2那样给大鼠作皮肤和皮下注射相关肽#1。

观察动物24小时且在24小时无痛处死动物。切取组织，固定在10％福尔马林中，石蜡包埋，染色并用标准组织病理学方法检测。

对照与实施例2相同。

结果：注射相关肽#1在注射部位产生细胞死亡和组织坏死。与上述实施例2类似，细胞死亡出现在注射了相关肽#1的肌肉组织、皮下结缔组织和真皮中。

远离炎症的轻度区域，对照显示出很轻微的坏死或细胞损失。对照注射在注射部位有轻度至很小的急性炎症偶有针头引起的灶性微出血。

实施例4

此实施例的目的是测定相关肽#2对注射部位组织的作用。

用乙醚将雄性Sprague-Dawley大鼠(体重范围300克)麻醉，并外科手术暴露前列腺后通过前列腺内灌输给予相关肽#2。注射剂包括300μl相关肽#2、1mg/mLPBS pH 7.4(1.0mg/kg)(n＝8)，对照仅注射PBS(n＝6)，并有未注射的对照(n＝2)。72小时后无痛处死动物。解剖前列腺，将其在10％的缓冲福尔马林中固定24小时，石蜡包埋，切片并用H&E染色。将每个动物的完整前列腺包埋并切片。所有染色切片进行组织学检测并进行测量。每个前列腺至少检测4张组织切片，测量每张组织切片相互垂直(90°)的两个截面的直径(每个前列腺总共测量8次或以上)。用每个前列腺这些测量值的平均直径，根据公式

V = \frac{4}{3} {(\frac{D}{2})}^{3}

估算体积。

对照与实施例1相同。

结果：如上述实施例1所示，注射相关肽#2第72小时造成了前列腺中显著的细胞损失和萎缩。对照显示出最轻微的变化或没有变化，包括针头引起的轻度灶性炎症。

实施例5

此实施例的目的是测定相关肽#3对注射部位组织的作用。

如实施例1和4在正常大鼠的前列腺中注射相关肽#3。72小时后无痛处死动物并如上述实施例1和4检测前列腺。

结果：与对照相比，在72小时时发现显著的细胞损失和萎缩，而对照只有最轻微的变化。

* * * *

已经参考特别优选的实施方案和例子描述了本发明。然而，此领域的技术人员应理解，可对本发明作出多种改变但不背离本发明的思路和或范围。

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<110>尼莫克斯股份有限公司(NYMOX CORPORATION)

<120>有效治疗肿瘤和其它需要除去或破坏细胞的疾病的肽

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<140>PCT/CA02/01106

<141>2002-07-19

<150>US 60/306,161

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<400>5

Met Phe Phe Val Leu Tyr Arg Phe Cys Phe Cys Phe Phe Glu Thr Glu

1 5 10 15

Ser His Ser Leu Thr Gln Ala Gly Val Gln Trp Cys Glu Leu Gly Ser

20 25 30

Pro Gln Pro Leu Pro Ser Gly Phe Lys Arg Phe Ser Cys Leu Ser Leu

35 40 45

Leu Ser Ser Trp Asp Tyr Ser His Glu Pro Pro His Pro Val Ile Cys

50 55 60

Ser Phe Leu Met Glu Lys Cys Leu Ile Leu Tyr Lys Pro Asn Gly Asp

65 70 75 80

Thr Ile Gly Pro Ile Leu Val Gln Gln Gly Lys Arg Gln Lys Leu Tyr

85 90 95

Ile Ser Ala Asp Leu Val His Leu Ile Ala

100 105

<210>6

<211>98

<212>PRT

<213>人工序列

<220>

<223>人工序列的描述：未知NTP肽

<400>6

Glu Ala Tyr Tyr Thr Met Leu His Leu Pro Thr Thr Asn Arg Pro Lys

1 5 10 15

Ile Ala His Cys Ile Leu Phe Asn Gln Pro His Ser Pro Arg Ser Asn

20 25 30

Ser His Ser His Pro Asn Pro Leu Lys Leu His Arg Arg Ser His Ser

35 40 45

His Asn Arg Pro Arg Ala Tyr Ile Leu Ile Thr Ile Leu Pro Ser Lys

50 55 60

Leu Lys Leu Arg Thr His Ser Gln Ser His His Asn Pro Leu Ser Arg

65 70 75 80

Thr Ser Asn Ser Thr Pro Thr Asn Ser Phe Leu Met Thr Ser Ser Lys

85 90 95

Pro Arg

<210>7

<211>75

<212>PRT

<213>人工序列

<220>

<223>人工序列的描述：未知NTP肽

<400>7

Ser Ser Ser Leu Gly Leu Pro Lys Cys Trp Asp Tyr Arg His Glu Leu

1 5 10 15

Leu Ser Leu Ala Leu Met Ile Asn Phe Arg Val Met Ala Cys Thr Phe

20 25 30

Lys Gln His Ile Glu Leu Arg Gln Lys Ile Ser Ile Val Pro Arg Lys

35 40 45

Leu Cys Cys Met Gly Pro Val Cys Pro Val Lys Ile Ala Leu Leu Thr

50 55 60

Ile Asn Gly His Cys Thr Trp Leu Pro Ala Ser

65 70 75

<210>8

<211>68

<212>PRT

<213>人工序列

<220>

<223>人工序列的描述：未知NTP肽

<400>8

Met Phe Val Phe Cys Leu Ile Leu Asn Arg Glu Lys Ile Lys Gly Gly

1 5 10 15

Asn Ser Ser Phe Phe Leu Leu Ser Phe Phe Phe Ser Phe Gln Asn Cys

20 25 30

Cys Gln Cys Phe Gln Cys Arg Thr Thr Glu Gly Tyr Ala Val Glu Cys

35 40 45

Phe Tyr Cys Leu Val Asp Lys Ala Ala Phe Glu Cys Trp Trp Phe Tyr

50 55 60

Ser Phe Asp Thr

65

<210>9

<211>61

<212>PRT

<213>智人(Homo sapiens)

<400>9

Met Glu Pro His Thr Val Ala Gln Ala Gly Val Pro Gln His Asp Leu

1 5 10 15

Gly Ser Leu Gln Ser Leu Leu Pro Arg Phe Lys Arg Phe Ser Cys Leu

20 25 30

Ile Leu Pro Lys Ile Trp Asp Tyr Arg Asn Met Asn Thr Ala Leu Ile

35 40 45

Lys Arg Asn Arg Tyr Thr Pro Glu Thr Gly Arg Lys Ser

50 55 60

<210>10

<211>5

<212>PRT

<213>人工序列

<220>

<223>人工序列的描述：合成肽

<400>10

Ser Ser Trp Asp Tyr

1 5

<210>11

<211>9

<212>PRT

<213>人工序列

<220>

<223>人工序列的描述：合成肽

<400>11

Pro Ala Ser Ala Ser Pro Val Ala Gly

1 5

<210>12

<211>11

<212>PRT

<213>人工序列

<220>

<223>人工序列的描述：合成肽

<400>12

Gly Ala Ile Ser Ala His Arg Asn Leu Arg Leu

1 5 10

<210>13

<211>6

<212>PRT

<213>人工序列

<220>

<223>人工序列的描述：合成肽

<400>13

Phe Phe Leu Val Glu Met

1 5

<210>14

<211>9

<212>PRT

<213>人工序列

<220>

<223>人工序列的描述：合成肽

<400>14

Ser Val Thr Gln Ala Gly Val Gln Trp

1 5

<210>15

<211>17

<212>PRT

<213>人工序列

<220>

<223>人工序列的描述：合成肽

<400>15

Ile Asp Gln Gln Val Leu Ser Arg Ile Lys Leu Glu Ile Lys Arg Cys

1 5 10 15

Leu

<210>16

<211>9

<212>PRT

<213>人工序列

<220>

<223>人工序列的描述：合成肽

<400>16

Leu Ser Arg Ile Lys Leu Glu Ile Lys

1 5

<210>17

<211>22

<212>PRT

<213>智人(Homo sapiens)

<400>17

Gly Asp His Gly Arg Pro Asn Leu Ser Arg Leu Lys Leu Ala Ile Lys

1 5 10 15

Tyr Glu Val Lys Lys Met

20

<210>18

<211>16

<212>PRT

<213>智人(Homo sapiens)

<400>18

Gln Gln Ser Ile Ala Val Lys Phe Leu Ala Val Phe Gly Val Ser Ile

1 5 10 15

<210>19

<211>21

<212>PRT

<213>智人(Homo sapiens)

<400>19

Gly Leu Leu Phe Pro Val Phe Ser Val Cys Tyr Leu Ile Ala Pro Lys

1 5 10 15

Ser Pro Leu Gly Leu

20

<210>20

<211>581

<212>PRT

<213>智人(Homo sapiens)

<400>20

Met Glu Val Ser Pro Leu Gln Pro Val Asn Glu Asn Met Gln Val Asn

1 5 10 15

Lys Ile Lys Lys Asn Glu Asp Ala Lys Lys Arg Leu Ser Val Glu Arg

20 25 30

I1e Tyr Gln Lys Lys Thr Gln Leu Glu His Ile Leu Leu Arg Pro Asp

35 40 45

Thr Tyr Ile Gly Ser Val Glu Leu Val Thr Gln Gln Met Trp Val Tyr

50 55 60

Asp Glu Asp Val Gly Ile Asn Tyr Arg Glu Val Thr Phe Val Pro Gly

65 70 75 80

Leu Tyr Lys Ile Phe Asp Glu Ile Leu Val Asn Ala Ala Asp Asn Lys

85 90 95

Gln Arg Asp Pro Lys Met Ser Cys Ile Arg Val Thr Ile Asp Pro Glu

100 105 110

Asn Asn Leu Ile Ser Ile Trp Asn Asn Gly Lys Gly Ile Pro Val Val

115 120 125

Glu His Lys Val Glu Lys Met Tyr Val Pro Ala Leu Ile Phe Gly Gln

130 135 140

Leu Leu Thr Ser Ser Asn Tyr Asp Asp Asp Glu Lys Lys Val Thr Gly

145 150 155 160

Gly Arg Asn Gly Tyr Gly Ala Lys Leu Cys Asn Ile Phe Ser Thr Lys

165 170 175

Phe Thr Val Glu Thr Ala Ser Arg Glu Tyr Lys Lys Met Phe Lys Gln

180 185 190

Thr Trp Met Asp Asn Met Gly Arg Ala Gly Glu Met Glu Leu Lys Pro

195 200 205

Phe Asn Gly Glu Asp Tyr Thr Cys Ile Thr Phe Gln Pro Asp Leu Ser

210 215 220

Lys Phe Lys Met Gln Ser Leu Asp Lys Asp Ile Val Ala Leu Met Val

225 230 235 240

Arg Arg Ala Tyr Asp Ile Ala Gly Ser Thr Lys Asp Val Lys Val Phe

245 250 255

Leu Asn Gly Asn Lys Leu Pro Val Lys Gly Phe Arg Ser Tyr Val Asp

260 265 270

Met Tyr Leu Lys Asp Lys Leu Asp Glu Thr Gly Asn Ser Leu Lys Val

275 280 285

Ile His Glu Gln Val Asn His Arg Trp Glu Val Cys Leu Thr Met Ser

290 295 300

Glu Lys Gly Phe Gln Gln Ile Ser Phe Val Asn Ser Ile Ala Thr Ser

305 310 315 320

Lys Gly Gly Arg His Val Asp Tyr Val Ala Asp Gln Ile Val Thr Lys

325 330 335

Leu Val Asp Val Val Lys Lys Lys Asn Lys Gly Gly Val Ala Val Lys

340 345 350

Ala His Gln Arg Glu Leu Cys Asn Gly Ala Ile Leu Ala His Cys Asn

355 360 365

Leu Arg Leu Met Gly Ser Ser Asp Ser Pro Ala Ser Ala Ser Arg Val

370 375 380

Ala Gly Ile Ala Gly Gly Cys His His Thr Gln Leu Ile Phe Val Phe

385 390 395 400

Leu Val Glu Thr Gly Phe His His Val Gly Gln Ala Gly Leu Glu Arg

405 410 415

Leu Thr Ser Gly Asp Pro Pro Ala Ser Ala Ser Gln Ser Ser Gly Ile

420 425 430

Thr Asp Val Lys Val Lys Asn His Met Trp Ile Phe Val Asn Ala Leu

435 440 445

Ile Glu Asn Pro Thr Phe Asp Ser Gln Thr Lys Glu Asn Met Thr Leu

450 455 460

Gln Pro Lys Ser Phe Gly Ser Thr Cys Gln Leu Ser Glu Lys Phe Ile

465 470 475 480

Lys Ala Ala Ile Gly Cys Gly Ile Val Glu Ser Ile Leu Asn Trp Val

485 490 495

Lys Phe Lys Ala Gln Val Gln Leu Asn Lys Lys Cys Ser Ala Val Lys

500 505 510

His Asn Arg Ile Lys Gly Ile Pro Lys Leu Asp Asp Ala Asn Asp Ala

515 520 525

Gly Gly Arg Asn Ser Thr Glu Cys Thr Leu Ile Leu Thr Glu Gly Asp

530 535 540

Ser Ala Lys Thr Leu Ala Val Ser Gly Leu Gly Val Val Gly Arg Asp

545 550 555 560

Lys Tyr Gly Val Phe Pro Leu Arg Gly Lys Ile Leu Asn Val Arg Glu

565 570 575

Ala Ser His Lys Gln

580

<210>21

<211>163

<212>PRT

<213>智人(Homo sapiens)

<400>21

Met Thr Gly Asp Lys Gly Pro Gln Arg Leu Ser Gly Ser Ser Tyr Gly

1 5 10 15

Ser Ile Ser Ser Pro Thr Ser Pro Thr Ser Pro Gly Pro Gln Gln Ala

20 25 30

Pro Pro Arg Glu Thr Tyr Leu Ser Glu Lys Ile Pro Ile Pro Asp Thr

35 40 45

Lys Pro Gly Thr Phe Ser Leu Arg Lys Leu Trp Ala Phe Thr Gly Pro

50 55 60

Gly Phe Leu Met Ser Ile Ala Phe Leu Asp Pro Gly Asn Ile Glu Ser

65 70 75 80

Asp Leu Gln Ala Gly Ala Val Ala Gly Phe Lys Leu Leu Trp Val Leu

85 90 95

Leu Trp Ala Thr Val Leu Gly Leu Leu Cys Gln Arg Leu Ala Ala Arg

100 105 110

Leu Gly Val Val Thr Gly Lys Asp Leu Gly Glu Val Cys His Leu Tyr

115 120 125

Tyr Pro Lys Ser Glu Ser Arg Ser Val Ala Gln Ser Gly Val Gln Trp

130 135 140

Cys Asp Val Ser Ser Leu Gln Pro Leu Pro Pro Arg Cys Pro Ala Pro

145 150 155 160

Ser Ser Gly

<210>22

<211>151

<212>PRT

<213>智人(Homo sapiens)

<400>22

Met Met Leu Ser Val Gln Glu Asn Val His Arg Cys Ile Cys Lys His

1 5 10 15

Tyr Ala Pro Pro Thr Ala Pro His Leu Phe Phe Glu Thr Glu Ser His

20 25 30

Ser Val Thr Gln Ala Gly Val Gln Trp Cys Asp Leu Gly Ser Leu Gln

35 40 45

Pro Ser Pro Pro Gly Phe Lys Gln Phe Ser Cys Leu Ser Leu Ser Arg

50 55 60

Ser Trp Asp Tyr Arg Arg Val Pro Leu Cys Leu Ala Asn Phe Ile Val

65 70 75 80

Phe Leu Val Glu Thr Gly Phe Cys Arg Val Gly Gln Ala Gly Leu Lys

85 90 95

Leu Leu Thr Ser Ser Asp Leu Pro Ala Ser Ala Cys Gln Ser Ala Gly

100 105 110

Asp Tyr Arg His Glu Pro Leu Arg Leu Ala Leu Thr Leu Cys His Phe

115 120 125

Ile Ser Arg Thr Cys Thr Ser Val Asp Phe Tyr Ile Cys Arg Asp Leu

130 135 140

Glu Arg Ile Pro His Gly His

145 150

<210>23

<211>129

<212>PRT

<213>智人(Homo sapiens)

<400>23

Met Ile Ser Ala His Arg Asn Leu His Leu Pro Gly Ser Ser Asn Ser

1 5 10 15

Pro Ala Ser Ala Phe Leu Ser Ser Trp Asp Tyr Arg His Val Pro Pro

20 25 30

Cys Pro Ala Asn Val Val Phe Leu Val Glu Met Gly Phe Leu His Val

35 40 45

Gly Gln Ala Gly Leu Glu Leu Pro Thr Ser Asp Asp Pro Pro Thr Leu

50 55 60

Ala Ser Gln Ser Ala Gly Ile Thr Gly Val Ser His Arg Thr Trp Gln

65 70 75 80

Glu Phe Ala Ser Leu Thr Val Ser Gln Ala Val Leu Arg Met Leu Val

85 90 95

Trp Gly Pro Gln Phe Glu Asn His Cys Ser Lys Leu Leu Met Ala Ser

100 105 110

Glu Gly Asp Ser Ser Leu Val Phe Phe Leu Tyr Pro Leu Ser Asn Leu

115 120 125

Asn

<210>24

<211>155

<212>PRT

<213>智人(Homo sapiens)

<400>24

Met Gln Gly Ser His Ser Ala Val Gln Ala Gly Val Trp Trp Cys His

1 5 10 15

His Asp Ser Leu Gln Pro Trp Pro Pro Gly Leu Arg Arg Ser Ser Cys

20 25 30

Leu Ser Leu Gln Ser Leu Trp Asp Tyr Arg Ser Leu Ala Leu Ser Leu

35 40 45

Arg Leu Ala Cys Asn Gly Thr Thr Ser Ala His Cys Asp Leu Cys Leu

50 55 60

Leu Ser Ser Ser Asp Ser Pro Ala Ser Ala Ser Gln Val Ala Gly Ile

65 70 75 80

Thr Gly Glu Lys Thr Ala Glu Pro His Lys Ala His Ala Ala Gln Gly

85 90 95

Glu Arg His Leu Ser Ser His Met Ser Pro Asp Glu Asn Met Thr Glu

100 105 110

Lys Phe Cys Pro Gly Pro Arg Ala Ser Phe His Leu Arg Ile Leu Ala

115 120 125

Ala Ser Arg His Leu Val Lys Arg Leu Leu Asn Glu Tyr Thr Val Thr

130 135 140

Val Leu Arg Asp Lys Ser Tyr Leu Arg Asn Asn

145 150 155

<210>25

<211>127

<212>PRT

<213>智人(Homo sapiens)

<400>25

Met Lys Asn Tyr Tyr Tyr Phe Leu Gly Gln Gly Leu Thr Leu Ser Pro

1 5 10 15

Arg Leu Glu Cys Ser Ser Thr Ile Ser Ala His Cys Asn Leu His Leu

20 25 30

Leu Gly Ser Ser Asn Ser Pro Val Ala Ala Ser Pro Val Ala Gly Thr

35 40 45

Thr Gly Thr Cys His His Asp Trp Leu Ile Phe Val Phe Leu Val Glu

50 55 60

Thr Gly Phe His His Ile Gly Gln Thr Gly Leu Glu Phe Leu Thr Ser

65 70 75 80

Gly Asp Pro Pro Thr Leu Ala Ser Lys Ser Ala Gly Ile Thr Gly Val

85 90 95

Ser His Cys Ala Trp Pro Thr Phe Leu Leu Asn Asp Met Arg His Ser

100 105 110

Phe Asn Lys Asn Leu Val Ile Ile Phe Tyr Val Pro Ala Ile Ser

115 120 125

<210>26

<211>137

<212>PRT

<213>智人(Homo sapiens)

<400>26

Met Arg Arg Glu Leu Leu Ala Gly Ile Leu Leu Arg Ile Thr Phe Asn

1 5 10 15

Phe Phe Leu Phe Phe Phe Leu Pro Phe Pro Leu Val Val Phe Phe Ile

20 25 30

Tyr Phe Tyr Phe Tyr Phe Phe Leu Glu Met Glu Ser His Tyr Val Ala

35 40 45

Gln Ala Gly Leu Glu Leu Leu Gly Ser Ser Asn Pro Pro Ala Ser Ala

50 55 60

Ser Leu Val Ala Gly Thr Leu Ser Val His His Cys Ala Cys Phe Glu

65 70 75 80

Ser Phe Thr Lys Arg Lys Lys Lys Leu Lys Lys Ala Phe Arg Phe Ile

85 90 95

Gln Cys Leu Leu Leu Gly Leu Leu Lys Val Arg Pro Leu Gln His Gln

100 105 110

Gly Val Asn Ser Cys Asp Cys Glu Arg Gly Tyr Phe Gln Gly Ile Phe

115 120 125

Met Gln Ala Ala Pro Trp Glu Gly Thr

130 135

<210>27

<211>1150

<212>PRT

<213>智人(Homo sapiens)

<400>27

Met Ser Lys Thr Leu Lys Lys Lys Lys His Trp Leu Ser Lys Val Gln

1 5 10 15

Glu Cys Ala Val Ser Trp Ala Gly Pro Pro Gly Asp Phe Gly Ala Glu

20 25 30

Ile Arg Gly Gly Ala Glu Arg Gly Glu Phe Pro Tyr Leu Gly Arg Leu

35 40 45

Arg Glu Glu Pro Gly Gly Gly Thr Cys Cys Ile Val Ser Gly Lys Ala

50 55 60

Pro Asn Pro Ser Asp Val Leu Leu Glu Val Asn Gly Thr Pro Val Ser

65 70 75 80

Gly Leu Thr Asn Arg Asp Thr Leu Ala Val Ile Arg His Phe Arg Glu

85 90 95

Pro Ile Arg Leu Lys Thr Val Lys Pro Gly Lys Val Ile Asn Lys Asp

100 105 110

Leu Arg His Tyr Leu Ser Leu Gln Phe Gln Lys Gly Ser Ile Asp His

115 120 125

Lys Leu Gln Gln Val Ile Arg Asp Asn Leu Tyr Leu Arg Thr Ile Pro

130 135 140

Cys Thr Thr Arg Ala Pro Arg Asp Gly Glu Val Pro Gly Val Asp Tyr

145 150 155 160

Asn Phe Ile Ser Val Glu Gln Phe Lys Ala Leu Glu Glu Ser Gly Ala

165 170 175

Leu Leu Glu Ser Gly Thr Tyr Asp Gly Asn Phe Tyr Gly Thr Pro Lys

180 185 190

Pro Pro Ala Glu Pro Ser Pro Phe Gln Pro Asp Pro Val Asp Gln Val

195 200 205

Leu Phe Asp Asn Glu Phe Asp Ala Glu Ser Gln Arg Lys Arg Thr Thr

210 215 220

Ser Val Ser Lys Met Glu Arg Met Asp Ser Ser Leu Pro Glu Glu Glu

225 230 235 240

Glu Asp Glu Asp Lys Gly Ala Ile Asn Gly Ser Gly Asn Ala Glu Asn

245 250 255

Arg Glu Arg His Ser Glu Ser Ser Asp Trp Met Lys Thr Val Pro Ser

260 265 270

Tyr Asn Gln Thr Asn Ser Ser Met Asp Phe Arg Asn Tyr Met Met Arg

275 280 285

Asp Glu Thr Leu Glu Pro Leu Pro Lys Asn Trp Glu Met Ala Tyr Thr

290 295 300

Asp Thr Gly Met Ile Tyr Phe Ile Asp His Asn Thr Lys Thr Thr Thr

305 310 315 320

Trp Leu Asp Pro Arg Leu Cys Lys Lys Ala Lys Ala Pro Glu Asp Cys

325 330 335

Glu Asp Gly Glu Leu Pro Tyr Gly Trp Glu Lys Ile Glu Asp Pro Gln

340 345 350

Tyr Gly Thr Tyr Tyr Val Asp Phe Thr Leu Val Ala Gln Ala Gly Val

355 360 365

Gln Trp His Asp Leu Gly Ser Leu Gln Pro Pro Pro Pro Gly Phe Asn

370 375 380

His Leu Asn Gln Lys Thr Gln Phe Glu Asn Pro Val Glu Glu Ala Lys

385 390 395 400

Arg Lys Lys Gln Leu Gly Gln Val Glu Ile Gly Ser Ser Lys Pro Asp

405 410 415

Met Glu Lys Ser His Phe Thr Arg Asp Pro Ser Gln Leu Lys Gly Val

420 425 430

Leu Val Arg Ala Ser Leu Lys Lys Ser Thr Met Gly Phe Gly Phe Thr

435 440 445

Ile Ile Gly Gly Asp Arg Pro Asp Glu Phe Leu Gln Val Lys Asn Val

450 455 460

Leu Lys Asp Gly Pro Ala Ala Gln Asp Gly Lys Ile Ala Pro Gly Asp

465 470 475 480

Val Ile Val Asp Ile Asn Gly Asn Cys Val Phe Gly His Thr His Ala

485 490 495

Asp Val Val Gln Met Phe Gln Leu Val Pro Val Asn Gln Tyr Val Asn

500 505 510

Leu Thr Leu Cys Arg Gly Tyr Pro Leu Pro Asp Asp Ser Glu Asp Pro

515 520 525

Val Val Asp Ile Val Ala Ala Thr Pro Val Ile Asn Gly Gln Ser Leu

530 535 540

Thr Lys Gly Glu Thr Cys Met Asn Pro Gln Asp Phe Lys Pro Gly Ala

545 550 555 560

Met Val Leu Glu Gln Asn Gly Lys Ser Gly His Thr Ser Thr Gly Asp

565 570 575

Gly Leu Asn Gly Pro Ser Asp Ala Ser Glu Gln Arg Val Ser Met Ala

580 585 590

Ser Ser Gly Ser Ser Gln Pro Glu Leu Val Thr Ile Pro Leu Ile Lys

595 600 605

Gly Pro Lys Gly Phe Gly Phe Ala Ile Ala Asp Ser Pro Thr Gly Gln

610 615 620

Lys Val Lys Met Ile Leu Asp Ser Gln Trp Cys Gln Gly Leu Gln Lys

625 630 635 640

Glu Asp Ile Ile Lys Glu Ile Tyr His Gln Asn Val Gln Asn Leu Thr

645 650 655

His Leu Gln Val Val Glu Val Leu Lys Gln Phe Pro Val Gly Ala Asp

660 665 670

Val Pro Leu Leu Ile Leu Arg Gly Gly Pro Pro Ser Thr Thr Lys Thr

675 680 685

Ala Lys Met Lys Thr Asp Lys Lys Glu Asn Ala Gly Ser Leu Glu Ala

690 695 700

Ile Asn Glu Pro Ile Pro Gln Pro Met Pro Phe Pro Pro Ser Ile Ile

705 710 715 720

Arg Ser Gly Ser Pro Lys Leu Asp Pro Ser Glu Val Tyr Leu Lys Ser

725 730 735

Lys Thr Leu Tyr Glu Asp Lys Pro Pro Asn Thr Lys Asp Leu Asp Val

740 745 750

Phe Leu Arg Lys Gln Glu Ser Gly Phe Gly Phe Arg Val Leu Gly Gly

755 760 765

Asp Gly Pro Asp Gln Ser Ile Tyr Ile Gly Ala Ile Ile Pro Leu Gly

770 775 780

Ala Ala Glu Lys Asp Gly Arg Leu Arg Ala Ala Asp Glu Leu Met Cys

785 790 795 800

Ile Asp Gly Ile Pro Val Lys Gly Lys Ser His Lys Gln Val Leu Asp

805 810 815

Leu Met Thr Thr Ala Ala Arg Asn Gly His Val Leu Leu Thr Val Arg

820 825 830

Arg Lys Ile Phe Tyr Gly Glu Lys Gln Pro Glu Asp Asp Ser Ser Gln

835 840 845

Ala Phe Ile Ser Thr Gln Asn Gly Ser Pro Arg Leu Asn Arg Ala Glu

850 855 860

Val Pro Ala Arg Pro Ala Pro Gln Glu Pro Tyr Asp Val Val Leu Gln

865 870 875 880

Arg Lys Glu Asn Glu Gly Phe Gly Phe Val Ile Leu Thr Ser Lys Asn

885 890 895

Lys Pro Pro Pro Gly Val Ile Pro His Lys Ile Gly Arg Val Ile Glu

900 905 910

Gly Ser Pro Ala Asp Arg Cys Gly Lys Leu Lys Val Gly Asp His Ile

915 920 925

Ser Ala Val Asn Gly Gln Ser Ile Val Glu Leu Ser His Ala Asn Ile

930 935 940

Val Gln Leu Ile Lys Asp Ala Gly Val Thr Val Thr Leu Thr Val Ile

945 950 955 960

Ala Glu Glu Glu His His Gly Pro Pro Ser Gly Thr Asn Ser Ala Arg

965 970 975

Gln Ser Pro Ala Leu Gln His Arg Pro Met Gly Gln Ser Gln Ala Asn

980 985 990

His Ile Pro Gly Asp Arg Ser Ala Leu Glu Gly Glu Ile Gly Lys Asp

995 1000 1005

Val Ser Thr Ser Tyr Arg His Ser Trp Ser Asp His Lys His Leu Ala

1010 1015 1020

Gln Pro Asp Thr Ala Val Ile Ser Val Val Gly Ser Arg His Asn Gln

1025 1030 1035 1040

Asn Leu Gly Cys Tyr Pro Val Glu Leu Glu Arg Gly Pro Arg Gly Phe

1045 1050 1055

Gly Phe Ser Leu Arg Gly Gly Lys Glu Tyr Asn Met Gly Leu Phe Ile

1060 1065 1070

Leu Arg Leu Ala Glu Asp Gly Pro Ala Ile Lys Asp Gly Arg Ile His

1075 1080 1085

Val Gly Asp Gln Ile Val Glu Ile Asn Gly Glu Pro Thr Gln Gly Ile

1090 1095 1100

Thr His Thr Arg Ala Ile Glu Leu Ile Gln Ala Gly Gly Asn Lys Val

1105 1110 1115 1120

Leu Leu Leu Leu Arg Pro Gly Thr Gly Leu Ile Pro Asp His Gly Leu

1125 1130 1135

Ala Pro Ser Gly Leu Cys Ser Tyr Val Lys Pro Glu Gln His

1140 1145 1150

<210>28

<211>253

<212>PRT

<213>智人(Homo sapiens)

<400>28

Met Ala Asp Asp Gln Gly Cys Ile Glu Glu Gln Gly Val Glu Asp Ser

1 5 10 15

Ala Asn Glu Asp Ser Val Asp Ala Lys Pro Asp Arg Ser Ser Phe Val

20 25 30

Pro Ser Leu Phe Ser Lys Lys Lys Lys Asn Val Thr Met Arg Ser Ile

35 40 45

Lys Thr Thr Arg Asp Arg Val Pro Thr Tyr Gln Tyr Asn Met Asn Phe

50 55 60

Glu Lys Leu Gly Lys Cys Ile Ile Ile Asn Asn Lys Asn Phe Asp Lys

65 70 75 80

Val Thr Gly Met Gly Val Arg Asn Gly Thr Asp Lys Asp Ala Glu Ala

85 90 95

Leu Phe Lys Cys Phe Arg Ser Leu Gly Phe Asp Val Ile Val Tyr Asn

100 105 110

Asp Cys Ser Cys Ala Lys Met Gln Asp Leu Leu Lys Lys Ala Ser Glu

115 120 125

Glu Asp His Thr Asn Ala Ala Cys Phe Ala Cys Ile Leu Leu Ser His

130 135 140

Gly Glu Glu Asn Met Glu Ser Cys Ser Val Thr Gln Ala Gly Val Gln

145 150 155 160

Arg Arg Asp Leu Gly Arg Leu Gln Pro Pro Pro Pro Arg Leu Ala Glu

165 170 175

Gly Pro Ser Leu Met Met Ala Ser Arg Pro Thr Arg Gly Pro Ser Met

180 185 190

Thr Gln Met Leu Ile Leu Asp Thr Arg Ser Gln Trp Lys Leu Thr Ser

195 200 205

Ser Ser Pro Ile Pro Arg Phe Gln Ala Ile Thr Arg Gly Gly Ala Gln

210 215 220

Glu Glu Ala Pro Gly Leu Cys Lys Pro Ser Ala Pro Ser Trp Arg Ser

225 230 235 240

Thr Glu Lys Thr Trp Lys Ser Cys Arg Ser Ser Pro Gly

245 250

<210>29

<211>111

<212>PRT

<213>智人(Homo sapiens)

<400>29

Met Gly Leu Ser Ile Ala Ser His Phe Gly Leu Leu Ile Lys Lys Val

1 5 10 15

Glu Arg Asn Ile Leu Phe Phe Phe Arg Arg Ser Leu Ala Leu Cys Gln

20 25 30

Ala Gly Val Gln Trp Arg Tyr Leu Ser Gln Leu Thr Ala Ala Ser Ala

35 40 45

Ser Trp Val Gln Ala Ile Leu Cys Leu Ser Leu Pro Ser Ser Trp Asp

50 55 60

Tyr Arg His Met Pro Pro Arg Pro Ala Asn Phe Cys Ile Leu Ser Arg

65 70 75 80

Asp Gly Ile Ser Pro Cys Trp Pro Gly Trp Ser Arg Ser Leu Asp Leu

85 90 95

Val Ile Arg Pro Pro Arg Pro Pro Lys Val Leu Arg Leu Gln Ala

100 105 110

<210>30

<211>118

<212>PRT

<213>智人(Homo sapiens)

<400>30

Met Gln Ile Ile Phe Phe Phe Leu Phe Leu Arg Trp Ser Phe Thr Leu

1 5 10 15

Val Ala Gln Ala Gly Val Gln Trp Arg Asp Leu Ser Ser Pro Gln Pro

20 25 30

Pro Pro Pro Arg Phe Lys Arg Phe Ser Cys Leu Ser Pro Pro Ser Ser

35 40 45

Trp Asp Tyr Arg His Ala Pro Pro His Pro Ala Asn Phe Val Phe Leu

50 55 60

Val Glu Thr Gly Phe Leu Arg Val Gly Gln Ala Gly Leu Glu Leu Leu

65 70 75 80

Thr Ser Gly Asp Pro Pro Ala Ser Ala Ser Gln Ser Ala Gly Ile Thr

85 90 95

Gly Val Ser His His Thr Gln Pro Asp Ala Asn Asn Phe Leu Arg Lys

100 105 110

Leu Phe Gln Lys Leu Phe

115

<210>31

<211>139

<212>PRT

<213>智人(Homo sapiens)

<400>31

Met Gly His Pro Arg Ala Ile Gln Pro Ser Val Phe Phe Ser Pro Tyr

1 5 10 15

Asp Val His Phe Leu Leu Tyr Pro Ile Arg Cys Pro Tyr Leu Lys Ile

20 25 30

Gly Arg Phe His Ile Lys Leu Lys Gly Leu His Phe Leu Phe Ser Phe

35 40 45

Leu Phe Phe Phe Phe Glu Thr Gln Ser His Ser Val Thr Arg Leu Glu

50 55 60

Cys Ser Gly Thr Ile Ser Ala His Cys Asn Leu Cys Leu Pro Gly Ser

65 70 75 80

Ser Asn Ser Pro Ala Ser Ala Ser Gln Val Ala Gly Thr Thr Gly Thr

85 90 95

Cys His His Ala Gln Leu Ile Phe Val Phe Leu Ala Glu Met Gly Phe

100 105 110

His His Ile Gly Gln Asp Gly Leu Asp Leu Asn Leu Val Ile His Pro

115 120 125

Pro Arg Ser Pro Lys Ala Leu Gly Leu Gln Ala

130 135

<210>32

<211>69

<212>PRT

<213>智人(Homo sapiens)

<400>32

Met Pro Asn His Tyr Ser Phe Cys Phe Cys Phe Cys Phe Cys Phe Arg

1 5 10 15

Arg Ser Leu Ala Leu Ser Pro Arg Leu Glu Cys Ser Gly Ala Ile Leu

20 25 30

Ala His Gly Lys Leu His Leu Pro Gly Ser Arg His Ser Pro Ala Ser

35 40 45

Ala Ser Pro Val Ala Gly Thr Lys Gly Ala Arg His His Ala Arg Leu

50 55 60

Ile Phe Leu Tyr Phe

65

<210>33

<211>162

<212>PRT

<213>智人(Homo sapiens)

<400>33

Leu Phe Thr Asn Ser Pro Phe Ser Leu Leu Ser Pro Ala Gln Trp Leu

1 5 10 15

Cys Phe Gly Thr His Leu Gly His Val Gln Ser Val Ser His Leu Gln

20 25 30

Trp Glu Gly Ser Val Gln Glu Ser Leu Arg Ser Val Arg Asn Ser Arg

35 40 45

Cys Ala Leu Pro Met Leu Ser Ala Pro Cys Ser Leu Ser Leu His Phe

50 55 60

Leu Leu Phe Ser Leu Ser Pro Phe Phe Phe Phe Glu Ile Arg Val Leu

65 70 75 80

Leu Tyr Arg Gln Ala Gly Val Gln Trp Cys Tyr Leu Gly Ser Leu Gln

85 90 95

Pro Leu Pro Pro Gly Phe Lys Gln Phe Ser Cys Leu Ser Tyr Pro Ser

100 105 110

Ser Trp Asp Tyr Arg Arg Pro Pro Pro Arg Gln Ala Asn Phe Cys Ile

115 120 125

Phe Ser Thr Asp Gly Val Ser Pro Cys Trp Pro Arg Trp Ser Leu Ser

130 135 140

Leu Asp Leu Met Ile Arg Pro Pro Gln Pro Pro Glu Val Leu Gly Leu

145 150 155 160

Gln Val

<210>34

<211>232

<212>PRT

<213>智人(Homo sapiens)

<400>34

Met Gly Arg Leu Val Leu Leu Trp Gly Ala Ala Val Phe Leu Leu Gly

1 5 10 15

Gly Trp Met Ala Leu Gly Gln Gly Gly Ala Glu Gly Val Gln Ile Gln

20 25 30

Ile Ile Tyr Phe Asn Leu Glu Thr Val Gln Val Thr Trp Asn Ala Ser

35 40 45

Lys Tyr Ser Arg Thr Asn Leu Thr Phe His Tyr Arg Phe Asn Gly Asp

50 55 60

Glu Ala Tyr Asp Gln Cys Thr Asn Tyr Leu Leu Gln Glu Gly His Thr

65 70 75 80

Ser Gly Cys Leu Leu Asp Ala Glu Gln Arg Asp Asp Ile Leu Tyr Phe

85 90 95

Ser Ile Arg Asn Gly Thr His Pro Val Phe Thr Ala Ser Arg Trp Met

100 105 110

Val Tyr Tyr Leu Lys Pro Ser Ser Pro Lys His Val Arg Phe Ser Trp

115 120 125

His Gln Asp Ala Val Thr Val Thr Cys Ser Asp Leu Ser Tyr Gly Asp

130 135 140

Leu Leu Tyr Glu Val Gln Tyr Arg Ser Pro Phe Asp Thr Glu Trp Gln

145 150 155 160

Thr Gln Ser Arg Ser Val Thr Gln Ala Gly Val Gln Trp Cys Asp Leu

165 170 175

Cys Leu Leu Gln Pro Ser Pro Pro Arg Phe Lys Arg Phe Ser Cys Leu

180 185 190

Ser Leu Pro Ser Ser Trp Asp Tyr Arg His Pro Pro Pro Arg Leu Ala

195 200 205

Asn Phe Cys Ile Ile Ser Arg Asp Gly Val Ser Pro Cys Trp Pro Gly

210 215 220

Trp Ser Arg Thr Cys Asp Leu Arg

225 230

<210>35

<211>506

<212>PRT

<213>智人(Homo sapiens)

<400>35

Met Glu Phe Leu Lys Val Ala Arg Arg Asn Lys Arg Glu Gln Leu Glu

1 5 10 15

Gln Ile Gln Lys Glu Leu Ser Val Leu Glu Glu Asp Ile Lys Arg Val

20 25 30

Glu Glu Met Ser Gly Leu Tyr Ser Pro Val Ser Glu Asp Ser Thr Val

35 40 45

Pro Gln Phe Glu Ala Pro Ser Pro Ser His Ser Ser Ile Ile Asp Ser

50 55 60

Thr Glu Tyr Ser Gln Pro Pro Gly Phe Ser Gly Ser Ser Gln Ala Gly

65 70 75 80

Val Gln Trp Arg Tyr Leu Gly Ser Leu Gln Pro Pro Pro Pro Arg Tyr

85 90 95

Lys Arg Phe Ser Cys Leu Thr Leu Pro Ser Ser Trp Asp Tyr Arg Arg

100 105 110

Leu Pro Pro His Leu Thr Lys Lys Gln Pro Trp Tyr Asn Ser Thr Leu

115 120 125

Ala Ser Arg Arg Lys Arg Leu Thr Ala His Phe Glu Asp Leu Glu Gln

130 135 140

Cys Tyr Phe Ser Thr Arg Met Ser Arg Ile Ser Asp Asp Ser Arg Thr

145 150 155 160

Ala Ser Gln Leu Asp Glu Phe Gln Glu Cys Leu Ser Lys Phe Thr Arg

165 170 175

Tyr Asn Ser Val Arg Pro Leu Ala Thr Leu Ser Tyr Ala Ser Asp Leu

180 185 190

Tyr Asn Gly Ser Ser Ile Val Ser Ser Ile Glu Phe Asp Arg Asp Cys

195 200 205

Asp Tyr Phe Ala Ile Ala Gly Val Thr Lys Lys Ile Lys Val Tyr Glu

210 215 220

Tyr Asp Thr Val Ile Gln Asp Ala Val Asp Ile His Tyr Pro Glu Asn

225 230 235 240

Glu Met Thr Cys Asn Ser Lys Ile Ser Cys Ile Ser Trp Ser Ser Tyr

245 250 255

His Lys Asn Leu Leu Ala Ser Ser Asp Tyr Glu Gly Thr Val Ile Leu

260 265 270

Trp Asp Gly Phe Thr Gly Gln Arg Ser Lys Val Tyr Gln Glu His Glu

275 280 285

Lys Arg Cys Trp Ser Val Asp Phe Asn Leu Met Asp Pro Lys Leu Leu

290 295 300

Ala Ser Gly Ser Asp Asp Ala Lys Val Lys Leu Trp Ser Thr Asn Leu

305 310 315 320

Asp Asn Ser Val Ala Ser Ile Glu Ala Lys Ala Asn Val Cys Cys Val

325 330 335

Lys Phe Ser Pro Ser Ser Arg Tyr His Leu Ala Phe Gly Cys Ala Asp

340 345 350

His Cys Val His Tyr Tyr Asp Leu Arg Asn Thr Lys Gln Pro Ile Met

355 360 365

Val Phe Lys Gly His Arg Lys Ala Val Ser Tyr Ala Lys Phe Val Ser

370 375 380

Gly Glu Glu Ile Val Ser Ala Ser Thr Asp Ser Gln Leu Lys Leu Trp

385 390 395 400

Asn Val Gly Lys Pro Tyr Cys Leu Arg Ser Phe Lys Gly His Ile Asn

405 410 415

Glu Lys Asn Phe Val Gly Leu Ala Ser Asn Gly Asp Tyr Ile Ala Cys

420 425 430

Gly Ser Glu Asn Asn Ser Leu Tyr Leu Tyr Tyr Lys Gly Leu Ser Lys

435 440 445

Thr Leu Leu Thr Phe Lys Phe Asp Thr Val Lys Ser Val Leu Asp Lys

450 455 460

Asp Arg Lys Glu Asp Asp Thr Asn Glu Phe Val Ser Ala Val Cys Trp

465 470 475 480

Arg Ala Leu Pro Asp Gly Glu Ser Asn Val Leu Ile Ala Ala Asn Ser

485 490 495

Gln Gly Thr Ile Lys Val Leu Glu Leu Val

500 505

<210>36

<211>120

<212>PRT

<213>智人(Homo sapiens)

<400>36

Met Gly Ser Tyr Phe Val Ala Arg Ala Gly Cys Lys Leu Leu Gly Leu

1 5 10 15

Lys Gly Thr Ser His Phe Ser Leu Pro Lys Cys Arg Asn Cys Arg Arg

20 25 30

Glu Pro Leu Pro Gly Leu Phe Phe Leu Phe Phe Val Phe Phe Phe Leu

35 40 45

Arg Arg Ser Leu Ala Leu Ser Pro Arg Leu Glu Cys Ser Gly Ala Ile

50 55 60

Val Ala His Cys Lys Leu Gly Leu Pro Gly Ser Leu His Ser Pro Ala

65 70 75 80

Ser Ala Ser Gln Val Ala Gly Thr Ile Gly Thr Cys His Asn Thr Arg

85 90 95

Ile Ile Phe Cys Ile Leu Val Glu Thr Gly Phe His Arg Val Ser Gln

100 105 110

Asp Gly Val Asp Leu Leu Thr Leu

115 120

<210>37

<211>257

<212>PRT

<213>智人(Homo sapiens)

<400>37

Met Asp Cys Gly Ser Val Gly Gly Gln Arg Thr Gln Arg Leu Pro Gly

1 5 10 15

Arg Gln Arg Leu Leu Phe Leu Pro Val Gly Leu Ser Gly Arg Pro Gly

20 25 30

Gly Ser Glu Thr Ser Ala Arg Arg Cys Pro Ser Ala Leu Ser Asp Gly

35 40 45

Leu Gly Ala Leu Arg Pro Arg Ala Pro Ala Ala Arg Gly Gly Val Ser

50 55 60

Arg Ala Ser Pro Leu Leu Leu Leu Leu Leu Val Pro Ser Pro Arg Leu

65 70 75 80

Ala Ala Ala Ala Pro Arg Arg Gln Leu Gly Asp Trp Glu Arg Ser Arg

85 90 95

Leu Gly Tyr Ala Ala Pro Pro Ala Gly Arg Ser Gly Ala Trp Arg Cys

100 105 110

Ser Pro Gly Val Ala Ala Ala Ala Gly Ala Leu Pro Gln Tyr His Gly

115 120 125

Pro Ala Pro Ala Leu Val Ser Cys Arg Arg Glu Leu Ser Leu Ser Ala

130 135 140

Gly Ser Leu Gln Leu Glu Arg Lys Arg Arg Asp Phe Thr Ser Ser Gly

145 150 155 160

Ser Arg Lys Leu Tyr Phe Asp Thr His Ala Leu Val Cys Leu Leu Glu

165 170 175

Asp Asn Glu Ser His Ser Phe Ile Gln Ala Gly Val Gln Trp His Ser

180 185 190

Leu Gly Leu Leu Gln Pro Pro Pro Pro Gly Phe Lys Arg Ser Ser His

195 200 205

Leu Ile Leu Leu Ser Ser Trp Asp Tyr Arg His Ala Pro Pro His Leu

210 215 220

Asp Asn Phe Ser Val Phe Leu Leu Glu Thr Gly Phe His His Val Gly

225 230 235 240

Gln Ala Gly Leu Lys Leu Leu Thr Ser Ser Asp Pro Pro Thr Leu Ala

245 250 255

Ser

<210>38

<211>438

<212>PRT

<213>智人(Homo sapiens)

<400>38

Met Ser Pro Ala Thr Thr Gly Thr Phe Leu Leu Thr Val Tyr Ser Ile

1 5 10 15

Phe Ser Lys Val His Ser Asp Arg Asn Val Tyr Pro Ser Ala Gly Val

20 25 30

Leu Phe Val His Val Leu Glu Arg Glu Tyr Phe Lys Gly Glu Phe Pro

35 40 45

Pro Tyr Pro Lys Pro Gly Glu Ile Ser Asn Asp Pro Ile Thr Phe Asn

50 55 60

Thr Asn Leu Met Gly Tyr Pro Asp Arg Pro Gly Trp Leu Arg Tyr Ile

65 70 75 80

Gln Arg Thr Pro Tyr Ser Asp Gly Val Leu Tyr Gly Ser Pro Thr Ala

85 90 95

Glu Asn Val Gly Lys Pro Thr Ile Ile Glu Ile Thr Ala Tyr Asn Arg

100 105 110

Arg Thr Phe Glu Thr Ala Arg His Asn Leu Ile Ile Asn Ile Met Ser

115 120 125

Ala Glu Asp Phe Pro Leu Pro Tyr Gln Ala Glu Phe Phe Ile Lys Asn

130 135 140

Met Asn Val Glu Glu Met Leu Ala Ser Glu Val Leu Gly Asp Phe Leu

145 150 155 160

Gly Ala Val Lys Asn Val Trp Gln Pro Glu Arg Leu Asn Ala Ile Asn

165 170 175

Ile Thr Ser Ala Leu Asp Arg Gly Gly Arg Val Pro Leu Pro Ile Asn

180 185 190

Asp Leu Lys Glu Gly Val Tyr Val Met Val Gly Ala Asp Val Pro Phe

195 200 205

Ser Ser Cys Leu Arg Glu Val Glu Asn Pro Gln Asn Gln Leu Arg Cys

210 215 220

Ser Gln Glu Met Glu Pro Val Ile Thr Cys Asp Lys Lys Phe Arg Thr

225 230 235 240

Gln Phe Tyr Ile Asp Trp Cys Lys Ile Ser Leu Val Asp Lys Thr Lys

245 250 255

Gln Val Ser Thr Tyr Gln Glu Val Ile Arg Gly Glu Gly Ile Leu Pro

260 265 270

Asp Gly Gly Glu Tyr Lys Pro Pro Ser Asp Ser Leu Lys Ser Arg Asp

275 280 285

Tyr Tyr Thr Asp Phe Leu Ile Thr Leu Ala Val Pro Ser Ala Val Ala

290 295 300

Leu Val Leu Phe Leu Ile Leu Ala Tyr Ile Met Cys Cys Arg Arg Glu

305 310 315 320

Gly Val Glu Lys Arg Asn Met Gln Thr Pro Asp Ile Gln Leu Val His

325 330 335

His Ser Ala Ile Gln Lys Ser Thr Lys Glu Leu Arg Asp Met Ser Lys

340 345 350

Asn Arg Glu Ile Ala Trp Pro Leu Ser Thr Leu Pro Val Phe His Pro

355 360 365

Val Thr Gly Glu Ile Ile Pro Pro Leu His Thr Asp Asn Tyr Asp Ser

370 375 380

Thr Asn Met Pro Leu Met Gln Thr Gln Gln Trp Ser Phe Ala Pro Val

385 390 395 400

Ala Gln Ala Gly Val Gln Trp Arg Asp Leu Gly Ser Leu Gln Pro Pro

405 410 415

Pro Pro Arg Asn Leu Pro His Gln Thr Gln Ile Pro Gln Gln Gln Thr

420 425 430

Thr Gly Lys Trp Tyr Pro

435

<210>39

<211>171

<212>PRT

<213>智人(Homo sapiens)

<400>39

Met Leu Gly Leu Arg Lys Ala Ala Ala Ile Ser Leu Leu Leu Arg Asn

1 5 10 15

Val Gly Leu Gln Leu Ala Thr Leu Leu Met Ser Gln Lys Lys Leu Gly

20 25 30

Phe Cys Gly Asn Phe Leu Phe Leu Asn Leu Ala Ile Ile Gln Thr Lys

35 40 45

Ile Ser Ser Ser Phe Phe Phe Phe Leu Arg Gln Ser Leu Thr Leu Ser

50 55 60

Pro Arg Leu Glu Cys Asn Gly Ala Ile Ser Ala His Cys His Leu Arg

65 70 75 80

Leu Pro Asp Ser Ser Asn Ser Pro Ala Ser Ala Ser Gln Val Thr Gly

85 90 95

Ile Thr Gly Ser His His His Ala Trp Leu Ile Phe Val Phe Leu Val

100 105 110

Glu Thr Gly Phe Cys His Val Gly Gln Asp Gly Leu Glu Leu Leu Thr

115 120 125

Ser Gly Asp Pro Pro Ala Ser Ala Ser Gln Ser Ala Gly Ile Thr Gly

130 135 140

Met Ser His His Thr Trp Pro Thr Asp Leu Phe Phe Lys Thr Val Leu

145 150 155 160

Pro Ala Arg Leu Gly Leu Trp Asp Ser Ser Val

165 170

<210>40

<211>365

<212>PRT

<213>智人(Homo sapiens)

<400>40

Met His Ala Val Pro Arg Gly Phe Gly Lys Lys Val Arg Val Gly Val

1 5 10 15

Gln Ser Cys Pro Ser Pro Phe Ser Gly Gln Ala Cys Pro Gln Pro Ser

20 25 30

Ser Val Phe Trp Ser Leu Leu Lys Asn Leu Pro Phe Leu Glu His Leu

35 40 45

Glu Leu Ile Gly Ser Asn Phe Ser Ser Ala Met Pro Arg Asn Glu Pro

50 55 60

Ala Ile Arg Asn Ser Leu Pro Pro Cys Ser Arg Ala Gln Ser Val Gly

65 70 75 80

Asp Ser Glu Val Ala Ala Ile Gly Gln Leu Ala Phe Leu Arg His Leu

85 90 95

Thr Leu Ala Gln Leu Pro Ser Val Leu Thr Gly Ser Gly Leu Val Asn

100 105 110

Ile Gly Pro Gln Cys Gln Gln Leu Arg Ser Leu Ser Leu Ala Asn Leu

115 120 125

Gly Met Met Gly Lys Val Val Tyr Met Pro Ala Leu Ser Asp Met Leu

130 135 140

Lys His Cys Lys Arg Leu Arg Asp Leu Arg Leu Glu Gln Pro Tyr Phe

145 150 155 160

Ser Ala Asn Ala Gln Phe Phe Gln Ala Leu Ser Gln Cys Pro Ser Leu

165 170 175

Gln Arg Leu Cys Leu Val Ser Arg Ser Gly Thr Leu Gln Pro Asp Ala

180 185 190

Val Leu Ala Phe Met Ala Arg Cys Leu Gln Val Val Met Cys His Leu

195 200 205

Phe Thr Gly Glu Ser Leu Ala Thr Cys Lys Ser Leu Gln Gln Ser Leu

210 215 220

Leu Arg Arg Trp Gly Glu Val Thr Gly Arg Arg Pro Gln Leu Phe Thr

225 230 235 240

Glu Leu Arg Glu Glu Pro Ser Ala Arg Thr Ser Arg Ala Thr Gly Arg

245 250 255

Arg Gln Pro Cys Leu Pro Asp Ser Gly Val Val Cys Cys Pro Cys Gly

260 265 270

Arg Pro Leu Ala Val Ser Gly Ile Ile Leu Val Gly Val Ser Pro Ser

275 280 285

Leu Val Val Lys Thr Thr Cys Val Tyr Arg Val Leu Phe Lys Asn Leu

290 295 300

Asp Tyr Ala Ser Ile Phe Phe Leu Val Cys Leu Phe Glu Thr Glu Ser

305 310 315 320

His Ser Val Val Gln Ala Gly Val Gln Trp Arg Asp Leu Ser Ser Leu

325 330 335

Gln Pro Leu Leu Ser Gly Leu Gln Pro Gln Pro Pro Glu Gln Leu Glu

340 345 350

Asn Glu Leu Glu Ile Gly Phe Ser Tyr Cys Phe Val Ile

355 360 365

<210>41

<211>125

<212>PRT

<213>智人(Homo sapiens)

<400>41

Met Glu Glu Asp Glu Phe Ile Gly Glu Lys Thr Phe Gln Arg Tyr Cys

1 5 10 15

Ala Glu Phe Ile Lys His Ser Gln Gln Ile Gly Asp Ser Trp Glu Trp

20 25 30

Arg Pro Ser Lys Asp Cys Ser Asp Gly Tyr Met Cys Lys Ile His Phe

35 40 45

Gln Ile Lys Asn Gly Ser Val Met Ser His Leu Gly Ala Ser Thr His

50 55 60

Gly Gln Thr Cys Leu Pro Met Glu Val Lys Ser Cys Ser Val Thr Gln

65 70 75 80

Ala Gly Val Gln Leu Arg Asp Leu Ser Ser Leu Gln Pro Pro Pro Ser

85 90 95

Gly Phe Lys Gln Phe Ser Cys Leu Ser Leu Pro Ser Asn Trp Asp Tyr

100 105 110

Arg Gly Ser Pro Leu His Leu Ala Asn Phe Leu Tyr Phe

115 120 125

<210>42

<211>120

<212>PRT

<213>智人(Homo sapiens)

<400>42

Met Thr Thr Cys Glu Phe Glu Phe Ile Phe Leu Lys Glu Gln Val Thr

1 5 10 15

Arg Ile Cys Asn Ile Ala Pro Leu Lys Ala Tyr Phe Ser Val His Lys

20 25 30

Met Gly Lys Ile Leu Lys Lys Leu Ser Asn Phe Ser Phe Leu Thr His

35 40 45

Arg Gln Ser Leu Thr Leu Ser Pro Arg Leu Glu Cys Ser Gly Ala Ile

50 55 60

Ser Ala His Cys Asn Leu His Leu Leu Gly Ser Ser Asn Ser Ala Ala

65 70 75 80

Ser Ala Ser Arg Val Ala Gly Thr Thr Gly Ala Cys His His Ala Gln

85 90 95

Leu Ile Phe Val Phe Leu Val Glu Thr Gly Phe His His Val Gly Gln

100 105 110

Asp Gly Leu Gly Leu Leu Thr Ser

115 120

<210>43

<211>643

<212>PRT

<213>智人(Homo sapiens)

<400>43

Met Ser Cys Asn Pro Ser Phe Gly Gly Ile Gly Lys Gly His Leu Met

1 5 10 15

Arg Glu Val Asp Ala Leu Asp Gly Leu Cys Ser Arg Ile Cys Asp Gln

20 25 30

Ser Gly Val His Tyr Lys Val Leu Asn Arg Arg Lys Gly Pro Ala Val

35 40 45

Trp Gly Leu Arg Ala Gln Ile Asp Arg Lys Leu Tyr Lys Gln Asn Met

50 55 60

Gln Lys Glu Ile Leu Asn Thr Pro Leu Leu Thr Val Gln Glu Gly Ala

65 70 75 80

Val Glu Asp Leu Ile Leu Thr Glu Pro Glu Pro Glu His Thr Gly Lys

85 90 95

Cys Arg Val Ser Gly Val Val Leu Val Asp Gly Ser Thr Val Tyr Ala

100 105 110

Glu Ser Val Ile Leu Thr Thr Gly Thr Phe Leu Arg Gly Met Ile Val

115 120 125

Ile Gly Leu Glu Thr His Pro Ala Gly Arg Leu Gly Asp Gln Pro Ser

130 135 140

Ile Gly Leu Ala Gln Thr Leu Glu Lys Leu Gly Phe Val Val Gly Arg

145 150 155 160

Leu Lys Thr Gly Thr Pro Pro Arg Ile Ala Lys Glu Ser Ile Asn Phe

165 170 175

Ser Ile Leu Asn Lys His Ile Pro Asp Asn Pro Ser Ile Pro Phe Ser

180 185 190

Phe Thr Asn Glu Thr Val Trp Ile Lys Pro Glu Asp Gln Leu Pro Cys

195 200 205

Tyr Leu Thr His Thr Asn Pro Arg Val Asp Glu Ile Val Leu Lys Asn

210 215 220

Leu His Leu Asn Ser His Val Lys Glu Thr Thr Arg Gly Pro Arg Tyr

225 230 235 240

Cys Pro Ser Ile Glu Ser Lys Val Leu Arg Phe Pro Asn Arg Leu His

245 250 255

Gln Val Trp Leu Glu Pro Glu Gly Met Asp Ser Asp Leu Ile Tyr Pro

260 265 270

Gln Gly Leu Ser Met Thr Leu Pro Ala Glu Leu Gln Glu Lys Met Ile

275 280 285

Thr Cys Ile Arg Gly Leu Glu Lys Ala Lys Val Ile Gln Pro Asp Gly

290 295 300

Val Leu Leu Leu Leu Pro Arg Met Glu Cys Asn Gly Ala Ile Ser Ala

305 310 315 320

His His Asn Leu Pro Leu Pro Gly Tyr Gly Val Gln Tyr Asp Tyr Leu

325 330 335

Asp Pro Arg Gln Ile Thr Pro Ser Leu Glu Thr His Leu Val Gln Arg

340 345 350

Leu Phe Phe Ala Gly Gln Ile Asn Gly Thr Thr Gly Tyr Glu Glu Ala

355 360 365

Ala Ala Gln Gly Val Ile Ala Gly Ile Asn Ala Ser Leu Arg Val Ser

370 375 380

Arg Lys Pro Pro Phe Val Val Ser Arg Thr Glu Gly Tyr Ile Gly Val

385 390 395 400

Leu Ile Asp Asp Leu Thr Thr Leu Gly Thr Ser Glu Pro Tyr Arg Met

405 410 415

Phe Thr Ser Arg Val Glu Phe Arg Leu Ser Leu Arg Pro Asp Asn Ala

420 425 430

Asp Ser Arg Leu Thr Leu Arg Gly Tyr Lys Asp Ala Gly Cys Val Ser

435 440 445

Gln Gln Arg Tyr Glu Arg Ala Cys Trp Met Lys Ser Ser Leu Glu Glu

450 455 460

Gly Ile Ser Val Leu Lys Ser Ile Glu Phe Leu Ser Ser Lys Trp Lys

465 470 475 480

Lys Leu Ile Pro Glu Ala Ser Ile Ser Thr Ser Arg Ser Leu Pro Val

485 490 495

Arg Ala Leu Asp Val Leu Lys Tyr Glu Glu Val Asp Met Asp Ser Leu

500 505 510

Ala Lys Ala Val Pro Glu Pro Leu Lys Lys Tyr Thr Lys Cys Arg Glu

515 520 525

Leu Ala Glu Arg Leu Lys Ile Glu Ala Thr Tyr Glu Ser Val Leu Phe

530 535 540

His Gln Leu Gln Glu Ile Lys Gly Val Gln Gln Asp Glu Ala Leu Gln

545 550 555 560

Leu Pro Lys Asp Leu Asp Tyr Leu Thr Ile Arg Asp Val Ser Leu Ser

565 570 575

His Glu Val Arg Glu Lys Leu His Phe Ser Arg Pro Gln Thr Ile Gly

580 585 590

Ala Ala Ser Arg Ile Pro Gly Val Thr Pro Ala Ala Ile Ile Asn Leu

595 600 605

Leu Arg Phe Val Lys Thr Thr Gln Arg Arg Gln Ser Ala Met Asn Glu

610 615 620

Ser Ser Lys Thr Asp Gln Tyr Leu Cys Asp Ala Asp Arg Leu Gln Glu

625 630 635 640

Arg Glu Leu

<210>44

<211>123

<212>PRT

<213>智人(Homo sapiens)

<400>44

Met Pro Phe Leu Tyr Asp Ile Ser Ser Cys Trp Thr Ser Phe Cys Phe

1 5 10 15

Leu Phe Phe Ser Pro Leu Asp Gly Val Leu Leu Cys Phe Pro Gly Trp

20 25 30

Asn Ala Val Ala Arg Ser Gln Leu Thr Ala Thr Ser Ala Ser Gln Val

35 40 45

Gln Ala Ile Leu Leu Val Ser Ala Ser Gly Val Ala Gly Ile Ile Gly

50 55 60

Thr Cys His His Ala Gln Pro Ile Phe Val Phe Leu Val Glu Met Gly

65 70 75 80

Phe His His Val Gly Gln Ala Cys Leu Lys Leu Leu Asn Ser Gly Asp

85 90 95

Pro Pro Ala Ser Ala Ser Gln Ser Ala Gly Ile Thr Gly Met Ser His

100 105 110

His Ala Arg Pro Phe Phe Phe Phe Phe Ser Phe

115 120

<210>45

<211>133

<212>PRT

<213>智人(Homo sapiens)

<400>45

Met Ser Glu Ala Glu Asn Glu Phe Ile Asn Trp Val Ala Thr Ala Ala

1 5 10 15

Ile Glu Ala Asn Cys Ser Gln Cys Trp Leu Cys Val Glu Leu Pro Glu

20 25 30

Ala Ala Gly Asn Gly Leu Pro Trp Arg Ile Val Pro Ala Asn Ile Ser

35 40 45

Glu Trp Ile Cys Gln Tyr Gln Trp Glu Trp Asp Asn Thr Trp Phe Cys

50 55 60

Phe Asp Phe Leu Ser Gln Ser Val Ser Leu Ser Pro Arg Leu Glu Cys

65 70 75 80

Ser Gly Thr Ile Leu Ala Gln Cys Asn Leu Cys Leu Leu Gly Ser Ser

85 90 95

Asp Ser Pro Ala Ser Ala Ser Gln Val Ala Gly Ile Ile Gly Ala Cys

100 105 110

Arg His Ala Trp Leu Ile Phe Cys Ile Phe Ser Arg Asp Gly Val Ser

115 120 125

Pro Tyr Cys Pro Gly

130

<210>46

<211>244

<212>PRT

<213>智人(Homo sapiens)

<400>46

Met Ala Leu Phe Leu Asp Lys Met Gly Ser Leu Gln Lys Gly Asn Tyr

1 5 10 15

Ser Ser Gln Ser Gly Met Ile Pro Gly Ser Trp Gln His Lys Met Lys

20 25 30

Leu Gln Leu Ile Leu Lys Ser Ser Lys Ala Tyr Tyr Val Leu Ser Asp

35 40 45

Ala Ala Met Ser Leu Gln Lys Tyr Gly Arg Ala Leu Arg Tyr Ile Lys

50 55 60

Leu Ala Leu Gln Ser His Asp Thr Tyr Cys Cys Leu Cys Thr Asn Met

65 70 75 80

Leu Ser Glu Val Leu Leu Phe Leu Ser Gln Tyr Leu Thr Leu Cys Gly

85 90 95

Asp Ile Gln Leu Met Leu Ala Gln Asn Ala Asn Asn Arg Ala Ala His

100 105 110

Leu Glu Glu Phe His Tyr Gln Thr Lys Glu Asp Gln Glu Ile Leu His

115 120 125

Ser Leu His Arg Glu Ser Ser Cys Gln Gly Val Pro Gln Ala Trp Thr

130 135 140

Thr Trp Phe Thr Val Gly Leu Cys Ser Leu Ala His Ala Tyr Leu Ser

145 150 155 160

Ile Gln Lys Arg Gly Arg Asn Ile Arg Val Leu Ile Phe Ala Leu Tyr

165 170 175

Leu Phe Ile Tyr Phe Leu Arg Arg Ser Phe Ala Leu Val Ala Gln Ala

180 185 190

Gly Val Gln Trp Cys Asn Leu Gly Ser Leu Lys Pro Pro Pro Pro Gly

195 200 205

Phe Lys Gln Phe Ser Cys Leu Ser Leu Pro Ser Ser Trp Asn Tyr Arg

210 215 220

His Ala Pro Pro Cys Pro Ala Ser Pro Pro Trp Pro Pro Lys Val Leu

225 230 235 240

Gly Leu Gln Val

<210>47

<211>79

<212>PRT

<213>智人(Homo sapiens)

<400>47

Arg Ser Leu Thr Leu Trp Pro Ser Leu Glu Tyr Ser Gly Thr Ile Ser

1 5 10 15

Ala His Cys Asn Leu Arg Leu Pro Gly Ser Ser Asp Ser Arg Ala Ser

20 25 30

Ala Ser Arg Ala Ala Gly Ile Thr Gly Val Ser His Cys Ala Arg Pro

35 40 45

Cys Met Leu Phe Asp Pro Glu Phe Asp Leu Leu Ala Gly Val Gln Leu

50 55 60

Leu Pro Phe Glu Pro Pro Thr Gly Lys Ala Leu Ser Arg Lys Asp

65 70 75

<210>48

<211>495

<212>PRT

<213>智人(Homo sapiens)

<400>48

Met Glu Phe Arg Lys Leu Arg Gly Met Glu Thr Arg Pro Pro Ala Asn

1 5 10 15

Thr Ala Arg Leu Gln Pro Pro Arg Asp Leu Arg Ser Ser Ser Pro Arg

20 25 30

Lys Gln Leu Ser Glu Ser Ser Asp Asp Asp Tyr Asp Asp Val Asp Ile

35 40 45

Pro Thr Pro Ala Glu Asp Thr Pro Pro Pro Leu Pro Pro Lys Pro Lys

50 55 60

Phe Arg Ser Pro Ser Asp Glu Gly Pro Gly Ser Met Gly Asp Asp Gly

65 70 75 80

Gln Leu Ser Pro Gly Val Leu Val Arg Cys Ala Ser Gly Pro Pro Pro

85 90 95

Asn Ser Pro Arg Pro Gly Pro Pro Pro Ser Thr Ser Ser Pro His Leu

100 105 110

Thr Ala His Ser Glu Pro Ser Leu Trp Asn Pro Pro Ser Arg Glu Leu

115 120 125

Asp Lys Pro Pro Leu Leu Pro Pro Lys Lys Glu Lys Met Lys Arg Lys

130 135 140

Gly Cys Ala Leu Leu Val Lys Leu Phe Asn Gly Cys Pro Leu Arg Ile

145 150 155 160

His Ser Thr Ala Ala Trp Thr His Pro Ser Thr Lys Asp Gln His Leu

165 170 175

Leu Leu Gly Ala Glu Glu Gly Ile Phe Ile Leu Asn Arg Asn Asp Gln

180 185 190

Glu Ala Thr Leu Glu Met Leu Phe Pro Ser Arg Thr Thr Trp Val Tyr

195 200 205

Ser Ile Asn Asn Val Leu Met Ser Leu Ser Gly Lys Thr Pro His Leu

210 215 220

Tyr Ser His Ser Ile Leu Gly Leu Leu Glu Arg Lys Glu Thr Arg Ala

225 230 235 240

Gly Asn Pro Ile Ala His Ile Ser Pro His Arg Leu Leu Ala Arg Lys

245 250 255

Asn Met Val Ser Thr Lys Ile Gln Asp Thr Lys Gly Cys Arg Ala Cys

260 265 270

Cys Val Ala Glu Gly Ala Ser Ser Gly Gly Pro Phe Leu Cys Gly Ala

275 280 285

Leu Glu Thr Ser Val Val Leu Leu Gln Trp Tyr Gln Pro Met Asn Lys

290 295 300

Phe Leu Leu Val Arg Gln Val Leu Phe Pro Leu Pro Thr Pro Leu Ser

305 310 315 320

Val Phe Ala Leu Leu Thr Gly Pro Gly Ser Glu Leu Pro Ala Val Cys

325 330 335

Ile Gly Val Ser Pro Gly Arg Pro Gly Lys Ser Val Leu Phe His Thr

340 345 350

Val Arg Phe Gly Ala Leu Ser Cys Trp Leu Gly Glu Met Ser Thr Glu

355 360 365

His Arg Gly Pro Val Gln Val Thr Gln Val Glu Glu Asp Met Val Met

370 375 380

Val Leu Met Asp Gly Ser Val Lys Leu Val Thr Pro Glu Gly Ser Pro

385 390 395 400

Val Arg Gly Leu Arg Thr Pro Glu Ile Pro Met Thr Glu Ala Val Glu

405 410 415

Ala Val Ala Met Val Gly Gly Gln Leu Gln Ala Phe Trp Lys His Gly

420 425 430

Val Gln Val Trp Ala Leu Gly Ser Asp Gln Leu Leu Gln Glu Leu Arg

435 440 445

Asp Pro Thr Leu Thr Phe Arg Leu Leu Gly Ser Pro Arg Leu Glu Cys

450 455 460

Ser Gly Thr Ile Ser Pro His Cys Asn Leu Leu Leu Pro Gly Ser Ser

465 470 475 480

Asn Ser Pro Ala Ser Ala Ser Arg Val Ala Gly Ile Thr Gly Leu

485 490 495

<210>49

<211>102

<212>PRT

<213>智人(Homo sapiens)

<400>49

Met Ser Met Val Leu Gly Gly Pro Phe Ser Lys Gly His Thr Ala Ser

1 5 10 15

Asp Glu Tyr Phe Gln Ile Phe His Asn Ile Ser Phe Phe Glu Thr Glu

20 25 30

Ser Cys Ser Val Ala Gln Ala Gly Val Gln Trp Cys Asn Leu Gly Ser

35 40 45

Leu Gln Ala Leu Pro Pro Arg Phe Thr Pro Phe Ser Cys Leu Ser Leu

50 55 60

Pro Ser Ser Trp Asp Tyr Arg His Pro Pro Pro Cys Pro Asp Asn Val

65 70 75 80

Phe Val Phe Ser Val Glu Thr Gly Leu His Cys Val Ser Gln Asp Gly

85 90 95

Leu Asn Leu Leu Thr Leu

100

<210>50

<211>257

<212>PRT

<213>智人(Homo sapiens)

<400>50

Met Asp Cys Gly Ser Val Gly Gly Gln Arg Thr Gln Arg Leu Pro Gly

1 5 101 5

Arg Gln Arg Leu Leu Phe Leu Pro Val Gly Leu Ser Gly Arg Pro Gly

20 25 30

Gly Ser Glu Thr Ser Ala Arg Arg Cys Leu Ser Ala Leu Ser Asp Gly

35 40 45

Leu Gly Ala Leu Arg Pro Arg Ala Pro Ala Ala Arg Gly Gly Val Ser

50 55 60

Arg Ala Ser Pro Leu Leu Leu Leu Leu Leu Val Pro Ser Pro Arg Leu

65 70 75 80

Ala Ala Ala Ala Pro Arg Arg Gln Leu Gly Asp Trp Glu Arg Ser Arg

85 90 95

Leu Gly Tyr Ala Ala Pro Pro Ala Gly Arg Ser Ser Ala Trp Arg Cys

100 105 110

Ser Pro Gly Val Ala Ala Ala Ala Gly Ala Leu Pro Gln Tyr His Gly

115 120 125

Pro Ala Pro Ala Leu Val Ser Cys Arg Arg Glu Leu Ser Leu Ser Ala

130 135 140

Gly Ser Leu Gln Leu Glu Arg Lys Arg Arg Asp Phe Thr Ser Ser Gly

145 150 155 160

Ser Arg Lys Leu Tyr Phe Asp Thr His Ala Leu Val Cys Leu Leu Glu

165 170 175

Asp Asn Glu Ser His Ser Phe Ile Gln Ala Gly Val Gln Trp His Ser

180 185 190

Leu Gly Leu Leu Gln Pro Pro Pro Pro Gly Phe Lys Arg Ser Ser His

195 200 205

Leu Ile Leu Leu Ser Ser Trp Asp Tyr Arg His Ala Pro Pro His Leu

210 215 220

Asp Asn Phe Ser Val Phe Leu Leu Glu Thr Gly Phe His His Val Gly

225 230 235 240

Gln Ala Gly Leu Lys Leu Leu Thr Ser Ser Asp Pro Pro Thr Leu Ala

245 250 255

Ser

<210>51

<211>92

<212>PRT

<213>智人(Homo sapiens)

<400>51

Met Asn Phe Phe Phe Lys Thr Glu Phe Leu Ser Val Thr Gln Ala Gly

1 5 10 15

Met Gln Trp His Asn Phe Ser Ser Leu Gln Pro Leu Pro Pro Gly Phe

20 25 30

Lys Gln Phe Ser Cys Leu Ser Leu Leu Ser Ser Trp Asp Tyr Arg His

35 40 45

Thr Pro Pro Cys Pro Ala Asn Phe Cys Ile Phe Ser Arg Gly Gly Val

50 55 60

Ser Pro Cys Trp Ser Gly Trp Ser Arg Thr Pro Asp Phe Met Ile His

65 70 75 80

Pro Pro Arg Pro Pro Lys Val Leu Arg Leu Gln Lys

85 90

<210>52

<211>841

<212>PRT

<213>智人(Homo sapiens)

<400>52

Met Pro Leu Ala Ala Tyr Cys Tyr Leu Arg Val Val Gly Lys Gly Ser

1 5 10 15

Tyr Gly Glu Val Thr Leu Val Lys His Arg Arg Asp Gly Lys Gln Tyr

20 25 30

Val Ile Lys Lys Leu Asn Leu Arg Asn Ala Ser Ser Arg Glu Arg Arg

35 40 45

Ala Ala Glu Gln Glu Ala Gln Leu Leu Ser Gln Leu Lys His Pro Asn

50 55 60

Ile Val Thr Tyr Lys Glu Ser Trp Glu Gly Gly Asp Gly Leu Leu Tyr

65 70 75 80

Ile Val Met Gly Phe Cys Glu Gly Gly Asp Leu Tyr Arg Lys Leu Lys

85 90 95

Glu Gln Lys Gly Gln Leu Leu Pro Glu Asn Gln Val Val Glu Trp Phe

100 105 110

Val Gln Ile Ala Met Ala Leu Gln Tyr Leu His Glu Lys His Ile Leu

115 120 125

His Arg Asp Leu Lys Thr Gln Asn Val Phe Leu Thr Arg Thr Asn Ile

130 135 140

Ile Lys Val Gly Asp Leu Gly Ile Ala Arg Val Leu Glu Asn His Cys

145 150 155 160

Asp Met Ala Ser Thr Leu Ile Gly Thr Pro Tyr Tyr Met Ser Pro Glu

165 170 175

Leu Phe Ser Asn Lys Pro Tyr Asn Tyr Lys Ser Asp Val Trp Ala Leu

180 185 190

Gly Cys Cys Val Tyr Glu Met Ala Thr Leu Lys His Ala Phe Asn Ala

195 200 205

Lys Asp Met Asn Ser Leu Val Tyr Arg Ile Ile Glu Gly Lys Leu Pro

210 215 220

Pro Met Pro Arg Asp Tyr Ser Pro Glu Leu Ala Glu Leu Ile Arg Thr

225 230 235 240

Met Leu Ser Lys Arg Pro Glu Glu Arg Pro Ser Val Arg Ser Ile Leu

245 250 255

Arg Gln Pro Tyr Ile Lys Arg Gln Ile Ser Phe Phe Leu Glu Ala Thr

260 265 270

Lys Ile Lys Thr Ser Lys Asn Asn Ile Lys Asn Gly Asp Ser Gln Ser

275 280 285

Lys Pro Phe Ala Thr Val Val Ser Gly Glu Ala Glu Ser Asn His Glu

290 295 300

Val Ile His Pro Gln Pro Leu Ser Ser Glu Gly Ser Gln Thr Tyr Ile

305 310 315 320

Met Gly Glu Gly Lys Cys Leu Ser Gln Glu Lys Pro Arg Ala Ser Gly

325 330 335

Leu Leu Lys Ser Pro Ala Ser Leu Lys Ala His Thr Cys Lys Gln Asp

340 345 350

Leu Ser Asn Thr Thr Glu Leu Ala Thr Ile Ser Ser Val Asn Ile Asp

355 360 365

Ile Leu Pro Ala Lys Gly Arg Asp Ser Val Ser Asp Gly Phe Val Gln

370 375 380

Glu Asn Gln Pro Arg Tyr Leu Asp Ala Ser Asn Glu Leu Gly Gly Ile

385 390 395 400

Cys Ser Ile Ser Gln Val Glu Glu Glu Met Leu Gln Asp Asn Thr Lys

405 410 415

Ser Ser Ala Gln Pro Glu Asn Leu Ile Pro Met Trp Ser Ser Asp Ile

420 425 430

Val Thr Gly Glu Lys Asn Glu Pro Val Lys Pro Leu Gln Pro Leu Ile

435 440 445

Lys Glu Gln Lys Pro Lys Asp Gln Ser Leu Ala Leu Ser Pro Lys Leu

450 455 460

Glu Cys Ser Gly Thr Ile Leu Ala His Ser Asn Leu Arg Leu Leu Gly

465 470 475 480

Ser Ser Asp Ser Pro Ala Ser Ala Ser Arg Val Ala Gly Ile Thr Gly

485 490 495

Val Cys His His Ala Gln Asp Gln Val Ala Gly Glu Cys Ile Ile Glu

500 505 510

Lys Gln Gly Arg Ile His Pro Asp Leu Gln Pro His Asn Ser Gly Ser

515 520 525

Glu Pro Ser Leu Ser Arg Gln Arg Arg Gln Lys Arg Arg Glu Gln Thr

530 535 540

Glu His Arg Gly Glu Lys Arg Gln Val Arg Arg Asp Leu Phe Ala Phe

545 550 555 560

Gln Glu Ser Pro Pro Arg Phe Leu Pro Ser His Pro Ile Val Gly Lys

565 570 575

Val Asp Val Thr Ser Thr Gln Lys Glu Ala Glu Asn Gln Arg Arg Val

580 585 590

Val Thr Gly Ser Val Ser Ser Ser Arg Ser Ser Glu Met Ser Ser Ser

595 600 605

Lys Asp Arg Pro Leu Ser Ala Arg Glu Arg Arg Arg Leu Lys Gln Ser

610 615 620

Gln Glu Glu Met Ser Ser Ser Gly Pro Ser Val Arg Lys Ala Ser Leu

625 630 635 640

Ser Val Ala Gly Pro Gly Lys Pro Gln Glu Glu Asp Gln Pro Leu Pro

645 650 655

Ala Arg Arg Leu Ser Ser Asp Cys Ser Val Thr Gln Glu Arg Lys Gln

660 665 670

Ile His Cys Leu Ser Glu Asp Glu Leu Ser Ser Ser Thr Ser Ser Thr

675 680 685

Asp Lys Ser Asp Gly Asp Tyr Gly Glu Gly Lys Gly Gln Thr Asn Glu

690 695 700

Ile Asn Ala Leu Val Gln Leu Met Thr Gln Thr Leu Lys Leu Asp Ser

705 710 715 720

Lys Glu Ser Cys Glu Asp Val Pro Val Ala Asn Pro Val Ser Glu Phe

725 730 735

Lys Leu His Arg Lys Tyr Arg Asp Thr Leu Ile Leu His Gly Lys Val

740 745 750

Ala Glu Glu Ala Glu Glu Ile His Phe Lys Glu Leu Pro Ser Ala Ile

755 760 765

Met Pro Gly Ser Glu Lys Ile Arg Arg Leu Val Glu Val Leu Arg Thr

770 775 780

Asp Val Ile Arg Gly Leu Gly Val Gln Leu Leu Glu Gln Val Tyr Asp

785 790 795 800

Leu Leu Glu Glu Glu Asp Glu Phe Asp Arg Glu Val Arg Leu Arg Glu

805 810 815

His Met Gly Glu Lys Tyr Thr Thr Tyr Ser Val Lys Ala Arg Gln Leu

820 825 830

Lys Phe Phe Glu Glu Asn Met Asn Phe

835 840

<210>53

<211>85

<212>PRT

<213>智人(Homo sapiens)

<400>53

Met Phe Ile Ser Phe Gly Arg Leu Ile Phe Ser Phe Phe Leu Thr Trp

1 5 10 15

Ser Leu Ser Leu Ser Pro Arg Leu Glu Cys Ser Gly Thr Ile Leu Ala

20 25 30

His Cys Asn Pro Thr Ser Gln Val Gln Ala Ile Leu Pro Ala Ser Ala

35 40 45

Ser Arg Val Ala Gly Ile Thr Gly Met His His His Thr Cys Leu Ile

50 55 60

Phe Val Leu Leu Val Lys Met Gly Phe Cys His Val Gly His Ala Gly

65 70 75 80

Leu Glu Leu Val Thr

85

<210>54

<211>73

<212>PRT

<213>智人(Homo sapiens)

<400>54

Met Glu Ser Gly Gln Pro Ser Leu Ser Phe Tyr Phe Leu Phe Ile Tyr

1 5 10 15

Phe Phe Glu Ile Gly Ser His Phe Val Thr Gln Ala Gly Val Gln Trp

20 25 30

His Asn Leu Asp Ser Leu Gln Leu Ser Leu Ala Ser Ala Pro Gln Val

35 40 45

Ala Gly Thr Thr Gly Ala Cys His His Ala Arg Leu Ile Phe Gly Val

50 55 60

Phe Cys Arg Asp Trp Val Leu Pro Cys

65 70

<210>55

<211>181

<212>PRT

<213>智人(Homo sapiens)

<400>55

Met Leu Leu Val Asp Ala Asp Gln Pro Glu Pro Met Arg Ser Gly Ala

1 5 10 15

Arg Glu Leu Ala Leu Phe Leu Thr Pro Glu Pro Gly Ala Glu Ala Lys

20 25 30

Glu Val Glu Glu Thr Ile Glu Gly Met Leu Leu Arg Leu Glu Glu Phe

35 40 45

Cys Ser Leu Ala Asp Leu Ile Arg Ser Asp Thr Ser Gln Ile Leu Glu

50 55 60

Glu Asn Ile Pro Val Leu Lys Ala Lys Leu Thr Glu Met Arg Gly Ile

65 70 75 80

Tyr Ala Lys Val Asp Arg Leu Glu Ala Phe Val Lys Met Val Gly His

85 90 95

His Val Ala Phe Leu Glu Ala Asp Val Leu Gln Ala Glu Arg Asp His

100 105 110

Gly Ala Phe Pro Gln Ala Leu Arg Arg Trp Leu Gly Ser Ala Gly Leu

115 120 125

Pro Ser Phe Arg Asn Val Glu Cys Ser Gly Thr Ile Pro Ala Arg Cys

130 135 140

Asn Leu Arg Leu Pro Gly Ser Ser Asp Ser Pro Ala Ser Ala Ser Gln

145 150 155 160

Val Ala Gly Ile Pro Glu Val Thr Cys Thr Gly Ala Arg Asp Val Arg

165 170 175

Ala Ala His Thr Val

180

<210>56

<211>876

<212>PRT

<213>大鼠(Rattus norvegicus)

<400>56

Met Ser Arg Gly Asn Glu Asn Arg Leu Thr His Arg Arg Gln Thr Val

1 5 10 15

Leu Arg Glu Lys Gly Arg Arg Leu Ala Asn Arg Gly Pro Ala Tyr Met

20 25 30

Phe Asn Asp His Ser Thr Ser Leu Ser Ile Glu Glu Glu Arg Phe Leu

35 40 45

Asp Ala Ala Glu Tyr Gly Asn Ile Pro Val Val Arg Lys Met Leu Glu

50 55 60

Glu Cys Leu Ser Leu Asn Val Asn Cys Val Asp Tyr Met Gly Gln Asn

65 70 75 80

Ala Leu Gln Leu Ala Val Ala Asn Glu His Leu Glu Ile Thr Glu Leu

85 90 95

Leu Leu Lys Lys Glu Asn Leu Ser Arg Val Gly Asp Ala Leu Leu Leu

100 105 110

Ala Ile Ser Lys Gly Tyr Val Arg Ile Val Glu Ala Ile Leu Asn His

115 120 125

Pro Ala Phe Ala Glu Gly Lys Arg Leu Ala Thr Ser Pro Ser Gln Ser

130 135 140

Glu Leu Gln Gln Asp Asp Phe Tyr Ala Tyr Asp Glu Asp Gly Thr Arg

145 150 155 160

Phe Ser His Asp Val Thr Pro Ile Ile Leu Ala Ala His Cys Gln Glu

165 170 175

Tyr Glu Ile Val His Thr Leu Leu Arg Lys Gly Ala Arg Ile Glu Arg

180 185 190

Pro His Asp Tyr Phe Cys Lys Cys Thr Glu Cys Ser Gln Lys Gln Lys

195 200 205

His Asp Ser Phe Ser His Ser Arg Ser Arg Ile Asn Ala Tyr Lys Gly

210 215 220

Leu Ala Ser Pro Ala Tyr Leu Ser Leu Ser Ser Glu Asp Pro Val Met

225 230 235 240

Thr Ala Leu Glu Leu Ser Asn Glu Leu Ala Val Leu Ala Asn Ile Glu

245 250 255

Lys Glu Phe Lys Asn Asp Tyr Arg Lys Leu Ser Met Gln Cys Lys Asp

260 265 270

Phe Val Val Gly Leu Leu Asp Leu Cys Arg Asn Thr Glu Glu Val Glu

275 280 285

Ala Ile Leu Asn Gly Asp Ala Glu Thr Arg Gln Pro Gly Asp Leu Ala

290 295 300

Arg Pro Asn Leu Ser Arg Leu Lys Leu Ala Ile Lys Tyr Glu Val Lys

305 310 315 320

Lys Phe Val Ala His Pro Asn Cys Gln Gln Gln Leu Leu Ser Ile Trp

325 330 335

Tyr Glu Asn Leu Ser Gly Leu Arg Gln Gln Thr Met Ala Val Lys Phe

340 345 350

Leu Val Val Leu Ala Val Ala Ile Gly Leu Pro Phe Leu Ala Leu Ile

355 360 365

Tyr Trp Cys Ala Pro Cys Ser Lys Met Gly Lys Ile Leu Arg Gly Pro

370 375 380

Phe Met Lys Phe Val Ala His Ala Ala Ser Phe Thr Ile Phe Leu Gly

385 390 395 400

Leu Leu Val Met Asn Ala Ala Asp Arg Phe Glu Gly Thr Lys Leu Leu

405 410 415

Pro Asn Glu Thr Ser Thr Asp Asn Ala Arg Gln Leu Phe Arg Met Lys

420 425 430

Thr Ser Cys Phe Ser Trp Met Glu Met Leu Ile Ile Ser Trp Val Ile

435 440 445

Gly Met Ile Trp Ala Glu Cys Lys Glu Ile Trp Thr Gln Gly Pro Lys

450 455 460

Glu Tyr Leu Phe Glu Leu Trp Asn Met Leu Asp Phe Gly Met Leu Ala

465 470 475 480

Ile Phe Ala Ala Ser Phe Ile Ala Arg Phe Met Ala Phe Trp His Ala

485 490 495

Ser Lys Ala Gln Ser Ile Ile Asp Ala Asn Asp Thr Leu Lys Asp Leu

500 505 510

Thr Lys Val Thr Leu Gly Asp Asn Val Lys Tyr Tyr Asn Leu Ala Arg

515 520 525

Ile Lys Trp Asp Pro Thr Asp Pro Gln Ile Ile Ser Glu Gly Leu Tyr

530 535 540

Ala Ile Ala Val Val Leu Ser Phe Ser Arg Ile Ala Tyr Ile Leu Pro

545 550 555 560

Ala Asn Glu Ser Phe Gly Pro Leu Gln Ile Ser Leu Gly Arg Thr Val

565 570 575

Lys Asp Ile Phe Lys Phe Met Val Ile Phe Ile Met Val Phe Val Ala

580 585 590

Phe Met Ile Gly Met Phe Asn Leu Tyr Ser Tyr Tyr Ile Gly Ala Lys

595 600 605

Gln Asn Glu Ala Phe Thr Thr Val Glu Glu Ser Phe Lys Thr Leu Phe

610 615 620

Trp Ala Ile Phe Gly Leu Ser Glu Val Lys Ser Val Val Ile Asn Tyr

625 630 635 640

Asn His Lys Phe Ile Glu Asn Ile Gly Tyr Val Leu Tyr Gly Val Tyr

645 650 655

Asn Val Thr Met Val Ile Val Leu Leu Asn Met Leu Ile Ala Met Ile

660 665 670

Asn Ser Ser Phe Gln Glu Ile Glu Asp Asp Ala Asp Val Glu Trp Lys

675 680 685

Phe Ala Arg Ala Lys Leu Trp Phe Ser Tyr Phe Glu Glu Gly Arg Thr

690 695 700

Leu Pro Val Pro Phe Asn Leu Val Pro Ser Pro Lys Ser Leu Leu Tyr

705 710 715 720

Leu Leu Leu Lys Phe Lys Lys Trp Met Ser Glu Leu Ile Gln Gly His

725 730 735

Lys Lys Gly Phe Gln Glu Asp Ala Glu Met Asn Lys Arg Asn Glu Glu

740 745 750

Lys Lys Phe Gly Ile Leu Gly Ser His Glu Asp Leu Ser Lys Phe Ser

755 760 765

Leu Asp Arg Asn Gln Leu Ala His Asn Lys Gln Ser Ser Thr Arg Ser

770 775 780

Ser Glu Asp Phe His Leu Asn Ser Phe Ser Asn Pro Pro Arg Gln Tyr

785 790 795 800

Gln Lys Ile Met Lys Arg Leu Ile Lys Arg Tyr Val Leu Gln Ala Gln

805 810 815

Ile Asp Lys Glu Ser Asp Glu Val Asn Glu Gly Glu Leu Lys Glu Ile

820 825 830

Lys Gln Asp Ile Ser Ser Leu Arg Tyr Glu Leu Leu Glu Glu Lys Ser

835 840 845

Gln Asn Thr Glu Asp Leu Ala Glu Leu Ile Arg Lys Leu Gly Glu Arg

850 855 860

Leu Ser Leu Glu Ser Lys Gln Glu Glu Ser Arg Arg

865 870 875

<210>57

<211>808

<212>PRT

<213>大鼠(Rattus norvegicus)

<400>57

Met Ser Arg Gly Asn Glu Asn Arg Leu Thr His Arg Arg Gln Thr Val

1 5 10 15

Leu Arg Glu Lys Gly Arg Arg Leu Ala Asn Arg Gly Pro Ala Tyr Met

20 25 30

Phe Asn Asp His Ser Thr Ser Leu Ser Ile Glu Glu Glu Arg Phe Leu

35 40 45

Asp Ala Ala Glu Tyr Gly Asn Ile Pro Val Val Arg Lys Met Leu Glu

50 55 60

Glu Cys Leu Ser Leu Asn Val Asn Cys Val Asp Tyr Met Gly Gln Asn

65 70 75 80

Ala Leu Gln Leu Ala Val Ala Asn Glu His Leu Glu Ile Thr Glu Leu

85 90 95

Leu Leu Lys Lys Glu Asn Leu Ser Arg Val Gly Asp Ala Leu Leu Leu

100 105 110

Ala Ile Ser Lys Gly Tyr Val Arg Ile Val Glu Ala Ile Leu Asn His

115 120 125

Pro Ala Phe Ala Glu Gly Lys Arg Leu Ala Thr Ser Pro Ser Gln Ser

130 135 140

Glu Leu Gln Gln Asp Asp Phe Tyr Ala Tyr Asp Glu Asp Gly Thr Arg

145 150 155 160

Phe Ser His Asp Val Thr Pro Ile Ile Leu Ala Ala His Cys Gln Glu

165 170 175

Tyr Glu Ile Val His Thr Leu Leu Arg Lys Gly Ala Arg Ile Glu Arg

180 185 190

Pro His Asp Tyr Phe Cys Lys Cys Thr Glu Cys Ser Gln Lys Gln Lys

195 200 205

His Asp Ser Phe Ser His Ser Arg Ser Arg Ile Asn Ala Tyr Lys Gly

210 215 220

Leu Ala Ser Pro Ala Tyr Leu Ser Leu Ser Ser Glu Asp Pro Val Met

225 230 235 240

Thr Ala Leu Glu Leu Ser Asn Glu Leu Ala Val Leu Ala Asn Ile Glu

245 250 255

Lys Glu Phe Lys Asn Asp Tyr Arg Lys Leu Ser Met Gln Cys Lys Asp

260 265 270

Phe Val Val Gly Leu Leu Asp Leu Cys Arg Asn Thr Glu Glu Val Glu

275 280 285

Ala Ile Leu Asn Gly Asp Ala Glu Thr Arg Gln Pro Gly Asp Leu Ala

290 295 300

Arg Pro Asn Leu Ser Arg Leu Lys Leu Ala Ile Lys Tyr Glu Val Lys

305 310 315 320

Lys Phe Val Ala His Pro Asn Cys Gln Gln Gln Leu Leu Ser Ile Trp

325 330 335

Tyr Glu Asn Leu Ser Gly Leu Arg Gln Gln Thr Met Ala Val Lys Phe

340 345 350

Leu Val Val Leu Ala Val Ala Ile Gly Leu Pro Phe Leu Ala Leu Ile

355 360 365

Tyr Trp Cys Ala Pro Cys Ser Lys Met Gly Lys Ile Leu Arg Gly Pro

370 375 380

Phe Met Lys Phe Val Ala His Ala Ala Ser Phe Thr Ile Phe Leu Gly

385 390 395 400

Leu Leu Val Met Asn Ala Ala Asp Arg Phe Glu Gly Thr Lys Leu Leu

405 410 415

Pro Asn Glu Thr Ser Thr Asp Asn Ala Arg Gln Leu Phe Arg Met Lys

420 425 430

Thr Ser Cys Phe Ser Trp Met Glu Met Leu Ile Ile Ser Trp Val Ile

435 440 445

Gly Met Ile Trp Ala Glu Cys Lys Glu Ile Trp Thr Gln Gly Pro Lys

450 455 460

Glu Tyr Leu Phe Glu Leu Trp Asn Met Leu Asp Phe Gly Met Leu Ala

465 470 475 480

Ile Phe Ala Ala Ser Phe Ile Ala Arg Phe Met Ala Phe Trp His Ala

485 490 495

Ser Lys Ala Gln Ser Ile Ile Asp Ala Asn Asp Thr Leu Lys Asp Leu

500 505 510

Thr Lys Val Thr Leu Gly Asp Asn Val Lys Tyr Tyr Asn Leu Ala Arg

515 520 525

Ile Lys Trp Asp Pro Thr Asp Pro Gln Ile Ile Ser Glu Gly Leu Tyr

530 535 540

Ala Ile Ala Val Val Leu Ser Phe Ser Arg Ile Ala Tyr Ile Leu Pro

545 550 555 560

Ala Asn Glu Ser Phe Gly Pro Leu Gln Ile Ser Leu Gly Arg Thr Val

565 570 575

Lys Asp Ile Phe Lys Phe Met Val Ile Phe Ile Met Val Phe Val Ala

580 585 590

Phe Met Ile Gly Met Phe Asn Leu Tyr Ser Tyr Tyr Ile Gly Ala Lys

595 600 605

Gln Asn Glu Ala Phe Thr Thr Val Glu Glu Ser Phe Lys Thr Leu Phe

6l0 615 620

Trp Ala Ile Phe Gly Leu Ser Glu Val Arg Ser Val Val Ile Asn Tyr

625 630 635 640

Asn His Lys Phe Ile Glu Asn Ile Gly Tyr Val Leu Tyr Gly Val Tyr

645 650 655

Asn Val Thr Met Val Ile Val Leu Leu Asn Met Leu Ile Ala Met Ile

660 665 670

Asn Ser Ser Phe Gln Glu Ile Glu Arg Asn Glu Glu Lys Lys Phe Gly

675 680 685

Ile Leu Gly Ser His Glu Asp Leu Ser Lys Phe Ser Leu Asp Arg Asn

690 695 700

Gln Leu Ala His Asn Lys Gln Ser Ser Thr Arg Ser Ser Glu Asp Phe

705 710 715 720

His Leu Asn Ser Phe Ser Asn Pro Pro Arg Gln Tyr Gln Lys Ile Met

725 730 735

Lys Arg Leu Ile Lys Arg Tyr Val Leu Gln Ala Gln Ile Asp Lys Glu

740 745 750

Ser Asp Glu Val Asn Glu Gly Glu Leu Lys Glu Ile Lys Gln Asp Ile

755 760 765

Ser Ser Leu Arg Tyr Glu Leu Leu Glu Glu Lys Ser Gln Asn Thr Glu

770 775 780

Asp Leu Ala Glu Leu Ile Arg Arg Leu Gly Glu Arg Leu Ser Leu Glu

785 790 795 800

Ser Lys Gln Glu Glu Ser Arg Arg

805

<210>58

<211>83

<212>PRT

<213>智人(Homo sapiens)

<400>58

Met Glu Ser Arg Ser Val Ala Gln Ala Gly Val Gln Trp Pro Asp Leu

1 5 10 15

Gly Ser Leu Gln Pro Leu Pro Pro Arg Phe Lys Arg Phe Phe Cys Leu

20 25 30

Ser Leu Gln Ser Ser Trp Asp Tyr Arg His Ala Pro Pro Arg Pro Ala

35 40 45

Asn Phe Val Phe Leu Val Glu Thr Gly Phe Cys His Val Ser Gln Ala

50 55 60

Gly Leu Glu Leu Leu Thr Ser Ser Asp Pro Pro Pro Arg Pro Pro Lys

65 70 75 80

Val Leu Arg

<210>59

<211>141

<212>PRT

<213>智人(Homo sapiens)

<400>59

Met Ile Ser Val His Cys Asn Leu Cys Leu Pro Gly Ser Ser Asp Pro

1 5 10 15

Pro Ala Ser Ala Ser Gln Val Ala Gly Ile Thr Gly Val Arg His Cys

20 25 30

Met Ala Ser Gly Ala Val Leu Asn Lys Val Arg Arg His Gln Cys Ser

35 40 45

Gly Asp Leu Glu Val Arg Gly Ser His Gly Ser Leu Gly Glu Ala Pro

50 55 60

Trp Gly Lys Ser Val Pro Gly Arg Gly Thr Ala Ser Arg Lys Gly Pro

65 70 75 80

Gly Ala Gly Val Ile Gly Asn Ser Lys Glu Ala Ser Thr Gly Arg Ala

85 90 95

Gln Trp Ser Ala Pro Val Ile Pro Ala Thr Gln Glu Ala Lys Ala Gly

100 105 110

Gly Leu Leu Glu Pro Arg Ser Leu Ile Ser Ala Trp Ala Thr Tyr Gln

115 120 125

Asp Leu Ile Ser Ile Asn Lys Leu Lys Glu Lys Arg Gly

130 135 140

<210>60

<211>177

<212>PRT

<213>智人(Homo sapiens)

<400>60

Met Thr Arg Ser Leu Phe Lys Gly Asn Phe Trp Ser Ala Asp Ile Leu

1 5 10 15

Ser Thr Ile Gly Tyr Asp Asn Ile Ile Gln His Leu Asn Asn Gly Arg

20 25 30

Lys Asn Cys Lys Glu Phe Glu Asp Phe Leu Lys Glu Arg Ala Ala Ile

35 40 45

Glu Glu Arg Tyr Gly Lys Asp Leu Leu Asn Leu Ser Arg Lys Lys Pro

50 55 60

Cys Gly Gln Ser Glu Ile Asn Thr Leu Lys Arg Ala Leu Glu Val Phe

65 70 75 80

Lys Gln Gln Val Asp Asn Val Ala Gln Cys His Ile Gln Leu Ala Gln

85 90 95

Ser Leu Arg Glu Glu Ala Arg Lys Met Glu Glu Phe Arg Glu Lys Gln

100 105 110

Lys Leu Gln Arg Lys Lys Met Glu Ser His Ser Val Thr Gln Ala Gly

115 120 125

Ala Gln Trp His Asp Leu Gly Ser Leu Gln Ala Leu Pro Pro Gly Phe

130 135 140

Met Pro Phe Ser Cys Leu Ser Leu Pro Ser Ser Trp Asn Tyr Arg Leu

145 150 155 160

Pro Pro Pro Pro Arg Leu Ala Glu Pro Arg Asn Gln Asp His Gly Val

165 170 175

Ala

<210>61

<211>66

<212>PRT

<213>智人(Homo sapiens)

<400>61

Met Glu Ser His Ser Val Thr Gln Ala Gly Val Gln Trp Arg Asp Leu

1 5 10 15

Gly Ser Leu Gln Pro Leu Pro Pro Gly Phe Lys Gln Phe Ser His Leu

20 25 30

Ser Leu Pro Ser Ser Trp Asp Tyr Arg Arg Val Pro Pro Tyr Leu Gly

35 40 45

Asn Phe Cys Ile Phe Ser Gly Glu Gly Val Ser Pro Cys Trp Pro Gly

50 55 60

Trp Ser

65

<210>62

<211>392

<212>PRT

<213>智人(Homo sapiens)

<400>62

Met Gly Ser Leu Ser Thr Ala Asn Val Glu Phe Cys Leu Asp Val Phe

1 5 10 15

Lys Glu Leu Asn Ser Asn Asn Ile Gly Asp Asn Ile Phe Phe Ser Ser

20 25 30

Leu Ser Leu Leu Tyr Ala Leu Ser Met Val Leu Leu Gly Ala Arg Gly

35 40 45

Glu Thr Ala Glu Gln Leu Glu Lys Val Leu His Phe Ser His Thr Val

50 55 60

Asp Ser Leu Lys Pro Gly Phe Lys Asp Ser Pro Lys Cys Ser Gln Ala

65 70 75 80

Gly Arg Ile His Ser Glu Phe Gly Val Glu Phe Ser Gln Ile Asn Gln

85 90 95

Pro Asp Ser Asn Cys Thr Leu Ser Ile Ala Asn Arg Leu Tyr Gly Thr

100 105 110

Lys Thr Met Ala Phe His Gln Gln Tyr Leu Ser Cys Ser Glu Lys Trp

115 120 125

Tyr Gln Ala Arg Leu Gln Thr Val Asp Phe Glu Gln Ser Thr Glu Glu

130 135 140

Thr Arg Lys Thr Ile Asn Ala Trp Val Glu Asn Lys Thr Asn Gly Lys

145 150 155 160

Val Ala Asn Leu Phe Gly Lys Ser Thr Ile Asp Pro Ser Ser Val Met

165 170 175

Val Leu Val Asn Thr Ile Tyr Phe Lys Gly Gln Arg Gln Asn Lys Phe

180 185 190

Gln Val Arg Glu Thr Val Lys Ser Pro Phe Gln Leu Ser Glu Gly Lys

195 200 205

Asn Val Thr Val Glu Met Met Tyr Gln Ile Gly Thr Phe Lys Leu Ala

210 215 220

Phe Val Lys Glu Pro Gln Met Gln Val Leu Glu Leu Pro Tyr Val Asn

225 230 235 240

Asn Lys Leu Ser Met Ile Ile Leu Leu Pro Val Gly Ile Ala Asn Leu

245 250 255

Lys Gln Ile Glu Lys Gln Leu Asn Ser Gly Thr Phe His Glu Trp Thr

260 265 270

Ser Ser Ser Asn Met Met Glu Arg Glu Val Glu Val His Leu Pro Arg

275 280 285

Phe Lys Leu Glu Ile Lys Tyr Glu Leu Asn Ser Leu Leu Lys Pro Leu

290 295 300

Gly Val Thr Asp Leu Phe Asn Gln Val Lys Ala Asp Leu Ser Gly Met

305 310 315 320

Ser Pro Thr Lys Gly Leu Tyr Leu Ser Lys Ala Ile His Lys Ser Tyr

325 330 335

Leu Asp Val Ser Glu Glu Gly Thr Glu Ala Ala Ala Ala Thr Gly Asp

340 345 350

Ser Ile Ala Val Lys Ser Leu Pro Met Arg Ala Gln Phe Lys Ala Asn

355 360 365

His Pro Phe Leu Phe Phe Ile Arg His Thr His Thr Asn Thr Ile Leu

370 375 380

Phe Cys Gly Lys Leu Ala Ser Pro

385 390

<210>63

<211>982

<212>PRT

<213>智人(Homo sapiens)

<400>63

Met Ala Gln Phe Tyr Tyr Lys Arg Asn Val Asn Ala Pro Tyr Arg Asp

1 5 10 15

Arg Ile Pro Leu Arg Ile Val Arg Ala Glu Ser Glu Leu Ser Pro Ser

20 25 30

Glu Lys Ala Tyr Leu Asn Ala Val Glu Lys Gly Asp Tyr Ala Ser Val

35 40 45

Lys Lys Ser Leu Glu Glu Ala Glu Ile Tyr Phe Lys Ile Asn Ile Asn

50 55 60

Cys Ile Asp Pro Leu Gly Arg Thr Ala Leu Leu Ile Ala Ile Glu Asn

65 70 75 80

Glu Asn Leu Glu Leu Ile Glu Leu Leu Leu Ser Phe Asn Val Tyr Val

85 90 95

Gly Asp Ala Leu Leu His Ala Ile Arg Lys Glu Val Val Gly Ala Val

100 105 110

Glu Leu Leu Leu Asn His Lys Lys Pro Ser Gly Glu Lys Gln Val Pro

115 120 125

Pro Ile Leu Leu Asp Lys Gln Phe Ser Glu Phe Thr Pro Asp Ile Thr

130 135 140

Pro Ile Ile Leu Ala Ala His Thr Asn Asn Tyr Glu Ile Ile Lys Leu

145 150 155 160

Leu Val Gln Lys Gly Val Ser Val Pro Arg Pro His Glu Val Arg Cys

165 170 175

Asn Cys Val Glu Cys Val Ser Ser Ser Asp Val Asp Ser Leu Arg His

180 185 190

Ser Arg Ser Arg Leu Asn Ile Tyr Lys Ala Leu Ala Ser Pro Ser Leu

195 200 205

Ile Ala Leu Ser Ser Glu Asp Pro Phe Leu Thr Ala Phe Gln Leu Ser

210 215 220

Trp Glu Leu Gln Glu Leu Ser Lys Val Glu Asn Glu Phe Lys Ser Glu

225 230 235 240

Tyr Glu Glu Leu Ser Arg Gln Cys Lys Gln Phe Ala Lys Asp Leu Leu

245 250 255

Asp Gln Thr Arg Ser Ser Arg Glu Leu Glu Ile Ile Leu Asn Tyr Arg

260 265 270

Asp Asp Asn Ser Leu Ile Glu Glu Gln Ser Gly Asn Asp Leu Ala Arg

275 280 285

Leu Lys Leu Ala Ile Lys Tyr Arg Gln Lys Glu Phe Val Ala Gln Pro

290 295 300

Asn Cys Gln Gln Leu Leu Ala Ser Arg Trp Tyr Asp Glu Phe Pro Gly

305 310 315 320

Trp Arg Arg Arg His Trp Ala Val Lys Met Val Thr Cys Phe Ile Ile

325 330 335

Gly Leu Leu Phe Pro Val Phe Ser Val Cys Tyr Leu Ile Ala Pro Lys

340 345 350

Ser Pro Leu Gly Leu Phe Ile Arg Lys Pro Phe Ile Lys Phe Ile Cys

355 360 365

His Thr Ala Ser Tyr Leu Thr Phe Leu Phe Leu Leu Leu Leu Ala Ser

370 375 380

Gln His Ile Asp Arg Ser Asp Leu Asn Arg Gln Gly Pro Pro Pro Thr

385 390 395 400

Ile Val Glu Trp Met Ile Leu Pro Trp Val Leu Gly Phe Ile Trp Gly

405 410 415

Glu Ile Lys Gln Met Trp Asp Gly Gly Leu Gln Asp Tyr Ile His Asp

420 425 430

Trp Trp Asn Leu Met Asp Phe Val Met Asn Ser Leu Tyr Leu Ala Thr

435 440 445

Ile Ser Leu Lys Ile Val Ala Phe Val Lys Tyr Ser Ala Leu Asn Pro

450 455 460

Arg Glu Ser Trp Asp Met Trp His Pro Thr Leu Val Ala Glu Ala Leu

465 470 475 480

Phe Ala Ile Ala Asn Ile Phe Ser Ser Leu Arg Leu Ile Ser Leu Phe

485 490 495

Thr Ala Asn Ser His Leu Gly Pro Leu Gln Ile Ser Leu Gly Arg Met

500 505 510

Leu Leu Asp Ile Leu Lys Phe Leu Phe Ile Tyr Cys Leu Val Leu Leu

515 520 525

Ala Phe Ala Asn Gly Leu Asn Gln Leu Tyr Phe Tyr Tyr Glu Glu Thr

530 535 540

Lys Gly Leu Thr Cys Lys Gly Ile Arg Cys Glu Lys Gln Asn Asn Ala

545 550 555 560

Phe Ser Thr Leu Phe Glu Thr Leu Gln Ser Leu Phe Trp Ser Ile Phe

565 570 575

Gly Leu Ile Asn Leu Tyr Val Thr Asn Val Lys Ala Gln His Glu Phe

580 585 590

Thr Glu Phe Val Gly Ala Thr Met Phe Gly Thr Tyr Asn Val Ile Ser

595 600 605

Leu Val Val Leu Leu Asn Met Leu Ile Ala Met Met Asn Asn Ser Tyr

610 615 620

Gln Leu Ile Ala Asp His Ala Asp Ile Glu Trp Lys Phe Ala Arg Thr

625 630 635 640

Lys Leu Trp Met Ser Tyr Phe Glu Glu Gly Gly Thr Leu Pro Thr Pro

645 650 655

Phe Asn Val Ile Pro Ser Pro Lys Ser Leu Trp Tyr Leu Ile Lys Trp

660 665 670

Ile Trp Thr His Leu Cys Lys Lys Lys Met Arg Arg Lys Pro Glu Ser

675 680 685

Phe Gly Thr Ile Gly Val Arg Thr Gln His Arg Arg Ala Ala Asp Asn

690 695 700

Leu Arg Arg His His Gln Tyr Gln Glu Val Met Arg Asn Leu Val Lys

705 710 715 720

Arg Tyr Val Ala Ala Met Ile Arg Asp Ala Lys Thr Glu Glu Gly Leu

725 730 735

Thr Glu Glu Asn Phe Lys Glu Leu Lys Gln Asp Ile Ser Ser Phe Arg

740 745 750

Phe Glu Val Leu Gly Leu Leu Arg Gly Ser Lys Leu Ser Thr Ile Gln

755 760 765

Ser Ala Asn Ala Ser Lys Glu Ser Ser Asn Ser Ala Asp Ser Asp Glu

770 775 780

Lys Ser Asp Ser Glu Gly Asn Ser Lys Asp Lys Lys Lys Asn Phe Ser

785 790 795 800

Leu Phe Asp Leu Thr Thr Leu Ile His Pro Arg Ser Ala Ala Ile Ala

805 810 815

Ser Glu Arg His Asn Ile Ser Asn Gly Ser Ala Leu Val Val Gln Glu

820 825 830

Pro Pro Arg Glu Lys Gln Arg Lys Val Asn Phe Val Thr Asp Ile Lys

835 840 845

Asn Phe Gly Leu Phe His Arg Arg Ser Lys Gln Asn Ala Ala Glu Gln

850 855 860

Asn Ala Asn Gln Ile Phe Ser Val Ser Glu Glu Val Ala Arg Gln Gln

865 870 875 880

Ala Ala Gly Pro Leu Glu Arg Asn Ile Gln Leu Glu Ser Arg Gly Leu

885 890 895

Ala Ser Arg Gly Asp Leu Ser Ile Pro Gly Leu Ser Glu Gln Cys Val

900 905 910

Leu Val Asp His Arg Glu Arg Asn Thr Asp Thr Leu Gly Leu Gln Val

915 920 925

Gly Lys Arg Val Cys Pro Phe Lys Ser Glu Lys Val Val Val Glu Asp

930 935 940

Thr Val Pro Ile Ile Pro Lys Glu Lys His Ala Lys Glu Glu Asp Ser

945 950 955 960

Ser Ile Asp Tyr Asp Leu Asn Leu Pro Asp Thr Val Thr His Glu Asp

965 970 975

Tyr Val Thr Thr Arg Leu

980

<210>64

<211>323

<212>PRT

<213>智人(Homo sapiens)

<400>64

Met Ala Gln Phe Tyr Tyr Lys Arg Asn Val Asn Ala Pro Tyr Arg Asp

1 5 10 15

Arg Ile Pro Leu Arg Ile Val Arg Ala Glu Ser Glu Leu Ser Pro Ser

20 25 30

Glu Lys Ala Tyr Leu Asn Ala Val Glu Lys Gly Asp Tyr Ala Ser Val

35 40 45

Lys Lys Ser Leu Glu Glu Ala Glu Ile Tyr Phe Lys Ile Asn Ile Asn

50 55 60

Cys Ile Asp Pro Leu Gly Arg Thr Ala Leu Leu Ile Ala Ile Glu Asn

65 70 75 80

Glu Asn Leu Glu Leu Ile Glu Leu Leu Leu Ser Phe Asn Val Tyr Val

85 90 95

Gly Asp Ala Leu Leu His Ala Ile Arg Lys Glu Val Val Gly Ala Val

100 105 110

Glu Leu Leu Leu Asn His Lys Lys Pro Ser Gly Glu Lys Gln Val Pro

115 120 125

Pro Ile Leu Leu Asp Lys Gln Phe Ser Glu Phe Thr Pro Asp Ile Thr

130 135 140

Pro Ile Ile Leu Ala Ala His Thr Asn Asn Tyr Glu Ile Ile Lys Leu

145 150 155 160

Leu Val Gln Lys Gly Val Ser Val Pro Arg Pro His Glu Mal Arg Cys

165 170 175

Asn Cys Val Glu Cys Val Ser Ser Ser Asp Val Asp Ser Leu Arg His

180 185 190

Ser Arg Ser Arg Leu Asn Ile Tyr Lys Ala Leu Ala Ser Pro Ser Leu

195 200 205

Ile Ala Leu Ser Ser Glu Asp Pro Phe Leu Thr Ala Phe Gln Leu Ser

210 215 220

Trp Glu Leu Gln Glu Leu Ser Lys Val Glu Asn Glu Phe Lys Ser Glu

225 230 235 240

Tyr Glu Glu Leu Ser Arg Gln Cys Lys Gln Phe Ala Lys Asp Leu Leu

245 250 255

Asp Gln Thr Arg Ser Ser Arg Glu Leu Glu Ile Ile Leu Asn Tyr Arg

260 265 270

Asp Asp Asn Ser Leu Ile Glu Glu Gln Ser Gly Asn Asp Leu Ala Arg

275 280 285

Leu Lys Leu Ala Ile Lys Tyr Arg Gln Lys Glu Ala Ser Tyr Gly Glu

290 295 300

Lys Leu Asn Arg Cys Gly Met Ala Asp Phe Arg Thr Thr Ser Met Ile

305 310 315 320

Gly Gly Ile

<210>65

<211>930

<212>PRT

<213>大鼠(Rattus norvegicus)

<400>65

Met Ser Gln Ser Pro Gly Phe Val Thr Arg Arg Gly Gly Ser Pro Lys

1 5 10 15

Ala Ala Pro Gly Ala Gly Ala Arg Arg Asn Glu Ser Gln Asp Tyr Leu

20 25 30

Leu Met Asp Glu Leu Gly Asp Asp Gly Tyr Pro Gln Leu Gln Gln Pro

35 40 45

Pro Tyr Gly Tyr Tyr Pro Ser Phe Arg Gly Asn Glu Asn Arg Leu Thr

50 55 60

His Arg Arg Gln Thr Val Leu Arg Glu Lys Gly Arg Arg Leu Ala Asn

65 70 75 80

Arg Gly Pro Ala Tyr Met Phe Asn Asp His Ser Thr Ser Leu Ser Ile

85 90 95

Glu Glu Glu Arg Phe Leu Asp Ala Ala Glu Tyr Gly Asn Ile Pro Val

100 105 110

Val Arg Lys Met Leu Glu Glu Cys Leu Ser Leu Asn Val Asn Cys Val

115 120 125

Asp Tyr Met Gly Gln Asn Ala Leu Gln Leu Ala Val Ala Asn Glu His

130 135 140

Leu Glu Ile Thr Glu Leu Leu Leu Lys Lys Glu Asn Leu Ser Arg Val

145 150 155 160

Gly Asp Ala Leu Leu Leu Ala Ile Ser Lys Gly Tyr Val Arg Ile Val

165 170 175

Glu Ala Ile Leu Asn His Pro Ala Phe Ala Glu Gly Lys Arg Leu Ala

180 185 190

Thr Ser Pro Ser Gln Ser Glu Leu Gln Gln Asp Asp Phe Tyr Ala Tyr

195 200 205

Asp Glu Asp Gly Thr Arg Phe Ser His Asp Val Thr Pro Ile Ile Leu

210 215 220

Ala Ala His Cys Gln Glu Tyr Glu Ile Val His Thr Leu Leu Arg Lys

225 230 235 240

Gly Ala Arg Ile Glu Arg Pro His Asp Tyr Phe Cys Lys Cys Thr Glu

245 250 255

Cys Ser Gln Lys Gln Lys His Asp Ser Phe Ser His Ser Arg Ser Arg

260 265 270

Ile Asn Ala Tyr Lys Gly Leu Ala Ser Pro Ala Tyr Leu Ser Leu Ser

275 280 285

Ser Glu Asp Pro Val Met Thr Ala Leu Glu Leu Ser Asn Glu Leu Ala

290 295 300

Val Leu Ala Asn Ile Glu Lys Glu Phe Lys Asn Asp Tyr Arg Lys Leu

305 310 315 320

Ser Met Gln Cys Lys Asp Phe Val Val Gly Leu Leu Asp Leu Cys Arg

325 330 335

Asn Thr Glu Glu Val Glu Ala Ile Leu Asn Gly Asp Ala Glu Thr Arg

340 345 350

Gln Pro Gly Asp Leu Ala Arg Pro Asn Leu Ser Arg Leu Lys Leu Ala

355 360 365

Ile Lys Tyr Glu Val Lys Lys Phe Val Ala His Pro Asn Cys Gln Gln

370 375 380

Gln Leu Leu Ser Ile Trp Tyr Glu Asn Leu Ser Gly Leu Arg Gln Gln

385 390 395 400

Thr Met Ala Val Lys Phe Leu Val Val Leu Ala Val Ala Ile Gly Leu

405 410 415

Pro Phe Leu Ala Leu Ile Tyr Trp Cys Ala Pro Cys Ser Lys Met Gly

420 425 430

Lys Ile Leu Arg Gly Pro Phe Met Lys Phe Val Ala His Ala Ala Ser

435 440 445

Phe Thr Ile Phe Leu Gly Leu Leu Val Met Asn Ala Ala Asp Arg Phe

450 455 450

Glu Gly Thr Lys Leu Leu Pro Asn Glu Thr Ser Thr Asp Asn Ala Arg

465 470 475 480

Gln Leu Phe Arg Met Lys Thr Ser Cys Phe Ser Trp Met Glu Met Leu

485 490 495

Ile Ile Ser Trp Val Ile Gly Met Ile Trp Ala Glu Cys Lys Glu Ile

500 505 510

Trp Thr Gln Gly Pro Lys Glu Tyr Leu Phe Glu Leu Trp Asn Met Leu

515 520 525

Asp Phe Gly Met Leu Ala Ile Phe Ala Ala Ser Phe Ile Ala Arg Phe

530 535 540

Met Ala Phe Trp His Ala Ser Lys Ala Gln Ser Ile Ile Asp Ala Asn

545 550 555 560

Asp Thr Leu Lys Asp Leu Thr Lys Val Thr Leu Gly Asp Asn Val Lys

565 570 575

Tyr Tyr Asn Leu Ala Arg Ile Lys Trp Asp Pro Thr Asp Pro Gln Ile

580 585 590

Ile Ser Glu Gly Leu Tyr Ala Ile Ala Val Val Leu Ser Phe Ser Arg

595 600 605

Ile Ala Tyr Ile Leu Pro Ala Asn Glu Ser Phe Gly Pro Leu Gln Ile

610 615 620

Ser Leu Gly Arg Thr Val Lys Asp Ile Phe Lys Phe Met Val Ile Phe

625 630 635 640

Ile Met Val Phe Val Ala Phe Met Ile Gly Met Phe Asn Leu Tyr Ser

645 650 655

Tyr Tyr Ile Gly Ala Lys Gln Asn Glu Ala Phe Thr Thr Val Glu Glu

660 665 670

Ser Phe Lys Thr Leu Phe Trp Ala Ile Phe Gly Leu Ser Glu Val Lys

675 680 685

Ser Val Val Ile Asn Tyr Asn His Lys Phe Ile Glu Asn Ile Gly Tyr

690 695 700

Val Leu Tyr Gly Val Tyr Asn Val Thr Met Val Ile Val Leu Leu Asn

705 710 715 720

Met Leu Ile Ala Met Ile Asn Ser Ser Phe Gln Glu Ile Glu Asp Asp

725 730 735

Ala Asp Val Glu Trp Lys Phe Ala Arg Ala Lys Leu Trp Phe Ser Tyr

740 745 750

Phe Glu Glu Gly Arg Thr Leu Pro Val Pro Phe Asn Leu Val Pro Ser

755 760 765

Pro Lys Ser Leu Leu Tyr Leu Leu Leu Lys Phe Lys Lys Trp Met Ser

770 775 780

Glu Leu Ile Gln Gly His Lys Lys Gly Phe Gln Glu Asp Ala Glu Met

785 790 795 800

Asn Lys Arg Asn Glu Glu Lys Lys Phe Gly Ile Leu Gly Ser His Glu

805 810 815

Asp Leu Ser Lys Phe Ser Leu Asp Arg Asn Gln Leu Ala His Asn Lys

820 825 830

Gln Ser Ser Thr Arg Ser Ser Glu Asp Phe His Leu Asn Ser Phe Ser

835 840 845

Asn Pro Pro Arg Gln Tyr Gln Lys Ile Met Lys Arg Leu Ile Lys Arg

850 855 860

Tyr Val Leu Gln Ala Gln Ile Asp Lys Glu Ser Asp Glu Val Asn Glu

865 870 875 880

Gly Glu Leu Lys Glu Ile Lys Gln Asp Ile Ser Ser Leu Arg Tyr Glu

885 890 895

Leu Leu Glu Glu Lys Ser Gln Asn Thr Glu Asp Leu Ala Glu Leu Ile

900 905 910

Arg Lys Leu Gly Glu Arg Leu Ser Leu Glu Ser Lys Gln Glu Glu Ser

915 920 925

Arg Arg

930

<210>66

<211>139

<212>PRT

<213>智人(Homo sapiens)

<400>66

Met Gly His Pro Arg Ala Ile Gln Pro Ser Val Phe Phe Ser Pro Tyr

1 5 10 15

Asp Val His Phe Leu Leu Tyr Pro Ile Arg Cys Pro Tyr Leu Lys Ile

20 25 30

Gly Arg Phe His Ile Lys Leu Lys Gly Leu His Phe Leu Phe Ser Phe

35 40 45

Leu Phe Phe Phe Phe Glu Thr Gln Ser His Ser Val Thr Arg Leu Glu

50 55 60

Cys Ser Gly Thr Ile Ser Ala His Cys Asn Leu Cys Leu Pro Gly Ser

65 70 75 80

Ser Asn Ser Pro Ala Ser Ala Ser Arg Val Ala Gly Thr Ala Gly Thr

85 90 95

Cys Arg Arg Ala Gln Leu Ile Phe Val Phe Leu Ala Glu Met Gly Phe

100 105 110

His His Val Gly Arg Asp Gly Leu Asp Leu Asn Leu Val Ile His Pro

115 120 125

Pro Arg Ser Pro Lys Ala Leu Gly Leu Gln Ala

130 135

<210>67

<21l>392

<212>PRT

<213>智人(Homo sapiens)

<400>67

Met Gly Ser Leu Ser Thr Ala Asn Val Glu Phe Cys Leu Asp Val Phe

1 5 10 15

Lys Glu Leu Asn Ser Asn Asn Ils Gly Asp Asn Ile Phe Phe Ser Ser

20 25 30

Leu Ser Leu Leu Tyr Ala Leu Ser Met Val Leu Leu Gly Ala Arg Gly

35 40 45

Glu Thr Ala Glu Gln Leu Glu Lys Val Leu His Phe Ser His Thr Val

50 55 60

Asp Ser Leu Lys Pro Gly Phe Lys Asp Ser Pro Lys Cys Ser Gln Ala

65 70 75 80

Gly Arg Ile His Ser Glu Phe Gly Val Glu Phe Ser Gln Ile Asn Gln

85 90 95

Pro Asp Ser Asn Cys Thr Leu Ser Ile Ala Asn Arg Leu Tyr Gly Thr

100 105 110

Lys Thr Met Ala Phe His Gln Gln Tyr Leu Ser Cys Ser Glu Lys Trp

115 120 125

Tyr Gln Ala Arg Leu Gln Thr Val Asp Phe Glu Gln Ser Thr Glu Glu

130 135 140

Thr Arg Lys Met Ile Asn Ala Trp Val Glu Asn Lys Thr Asn Gly Lys

145 150 155 160

Val Ala Asn Leu Phe Gly Lys Ser Thr Ile Asp Pro Ser Ser Val Met

165 170 175

Val Leu Val Asn Thr Ile Tyr Phe Lys Gly Gln Arg Gln Asn Lys Phe

180 185 190

Gln Val Arg Glu Thr Val Lys Ser Pro Phe Gln Leu Ser Glu Gly Lys

195 200 205

Asn Val Thr Val Glu Met Met Tyr Gln Ile Gly Thr Phe Lys Leu Ala

210 215 220

Phe Val Lys Glu Pro Gln Met Gln Val Leu Glu Leu Pro Tyr Val Asn

225 230 235 240

Asn Lys Leu Ser Met Ile Ile Leu Leu Pro Val Gly Ile Ala Asn Leu

245 250 255

Lys Gln Ile Glu Lys Gln Leu Asn Ser Gly Thr Phe His Glu Trp Thr

260 265 270

Ser Ser Ser Asn Met Met Glu Arg Glu Val Glu Val His Leu Pro Arg

275 280 285

Phe Lys Leu Glu Ile Lys Tyr Glu Leu Asn Ser Leu Leu Lys Pro Leu

290 295 300

Gly Val Thr Asp Leu Phe Asn Gln Val Lys Ala Asp Leu Ser Gly Met

305 310 315 320

Ser Pro Thr Lys Gly Leu Tyr Leu Ser Lys Ala Ile His Lys Ser Tyr

325 330 335

Leu Asp Val Ser Glu Glu Gly Thr Glu Ala Ala Ala Ala Thr Gly Asp

340 345 350

Ser Ile Ala Val Lys Ser Leu Pro Met Arg Ala Gln Phe Lys Ala Asn

355 360 365

His Pro Phe Leu Phe Phe Ile Arg His Thr His Thr Asn Thr Ile Leu

370 375 380

Phe Cys Gly Lys Leu Ala Ser Pro

385 390

<210>68

<211>862

<212>PRT

<213>智人(Homo sapiens)

<400>68

Met Leu Arg Asn Ser Thr Phe Lys Asn Met Gln Arg Arg His Thr Thr

1 5 10 15

Leu Arg Glu Lys Gly Arg Arg Gln Ala Ile Arg Gly Pro Ala Tyr Met

20 25 30

Phe Asn Glu Lys Gly Thr Ser Leu Thr Pro Glu Glu Glu Arg Phe Leu

35 40 45

Asp Ser Ala Glu Tyr Gly Asn Ile Pro Val Val Arg Lys Met Leu Glu

50 55 60

Glu Ser Lys Thr Leu Asn Phe Asn Cys Val Asp Tyr Met Gly Gln Asn

65 70 75 80

Ala Leu Gln Leu Ala Val Gly Asn Glu His Leu Glu Val Thr Glu Leu

85 90 95

Leu Leu Lys Lys Glu Asn Leu Ala Arg Val Gly Asp Ala Leu Pro Leu

100 105 110

Ala Ile Ser Lys Gly Tyr Val Arg Ile Val Glu Ala Ile Leu Asn His

115 120 125

Pro Ala Phe Ala Gln Gly Gln Arg Leu Thr Leu Ser Pro Leu Glu Gln

130 135 140

Glu Leu Arg Asp Asp Asp Phe Tyr Ala Tyr Asp Glu Asp Gly Thr Arg

145 150 155 160

Phe Ser His Asp Ile Thr Pro Ile Ile Leu Ala Ala His Cys Gln Glu

165 170 175

Tyr Glu Ile Val His Ile Leu Leu Leu Lys Gly Ala Arg Ile Glu Arg

180 185 190

Pro His Asp Tyr Phe Cys Lys Cys Asn Glu Cys Thr Glu Lys Gln Arg

195 200 205

Lys Asp Ser Phe Ser His Ser Arg Ser Arg Met Asn Ala Tyr Lys Gly

2l0 215 220

Leu Ala Ser Ala Ala Tyr Leu Ser Leu Ser Ser Glu Asp Pro Val Leu

225 230 235 240

Thr Ala Leu Glu Leu Ser Asn Glu Leu Ala Arg Leu Ala Asn Ile Glu

245 250 255

Thr Glu Phe Lys Asn Asp Tyr Arg Lys Leu Ser Met Gln Cys Lys Asp

260 265 270

Phe Val Val Gly Val Leu Asp Leu Cys Arg Asp Thr Glu Glu Val Glu

275 280 285

Ala Ile Leu Asn Gly Asp Val Asn Phe Gln Val Trp Ser Asp His His

290 295 300

Arg Pro Ser Leu Ser Arg Ile Lys Leu Ala Ile Lys Tyr Glu Val Lys

305 310 315 320

Lys Phe Val Ala His Pro Asn Cys Gln Gln Gln Leu Leu Thr Met Trp

325 330 335

Tyr Glu Asn Leu Ser Gly Leu Arg Gln Gln Ser Ile Ala Val Lys Phe

340 345 350

Leu Ala Val Phe Gly Val Ser Ile Gly Leu Pro Phe Leu Ala Ile Ala

355 360 365

Tyr Trp Ile Ala Pro Cys Ser Lys Leu Gly Arg Thr Leu Arg Ser Pro

370 375 380

Phe Met Lys Phe Val Ala His Ala Val Ser Phe Thr Ile Phe Leu Gly

385 390 395 400

Leu Leu Val Val Asn Ala Ser Asp Arg Phe Glu Gly Val Lys Thr Leu

405 410 415

Pro Asn Glu Thr Phe Thr Asp Tyr Pro Lys Gln Ile Phe Arg Val Lys

420 425 430

Thr Thr Gln Phe Ser Trp Thr Glu Met Leu Ile Met Lys Trp Val Leu

435 440 445

Gly Met Ile Trp Ser Glu Cys Lys Glu Ile Trp Glu Glu Gly Pro Arg

450 455 460

Glu Tyr Val Leu His Leu Trp Asn Leu Leu Asp Phe Gly Met Leu Ser

465 470 475 480

Ile Phe Val Ala Ser Phe Thr Ala Arg Phe Met Ala Phe Leu Lys Ala

485 490 495

Thr Glu Ala Gln Leu Tyr Val Asp Gln His Val Gln Asp Asp Thr Leu

500 505 510

His Asn Val Ser Leu Pro Pro Glu Val Ala Tyr Phe Thr Tyr Ala Arg

515 520 525

Asp Lys Trp Trp Pro Ser Asp Pro Gln Ile Ile Ser Glu Gly Leu Tyr

530 535 540

Ala Ile Ala Val Val Leu Ser Phe Ser Arg Ile Ala Tyr Ile Leu Pro

545 550 555 560

Ala Asn Glu Ser Phe Gly Pro Leu Gln Ile Ser Leu Gly Arg Thr Val

565 570 575

Lys Asp Ile Phe Lys Phe Met Val Ile Phe Ile Met Val Phe Val Ala

580 585 590

Phe Met Ile Gly Met Phe Asn Leu Tyr Ser Tyr Tyr Arg Gly Ala Lys

595 600 605

Tyr Asn Pro Ala Phe Thr Thr Val Glu Glu Ser Phe Lys Thr Leu Phe

610 615 620

Trp Ser Ile Phe Gly Leu Ser Glu Val Ile Ser Val Val Leu Lys Tyr

625 630 635 640

Asp His Lys Phe Ile Glu Asn Ile Gly Tyr Val Leu Tyr Gly Val Tyr

645 650 655

Asn Val Thr Met Val Val Val Leu Leu Asn Met Leu Ile Ala Met Ile

660 665 670

Asn Asn Ser Tyr Gln Glu Ile Glu Glu Asp Ala Asp Val Glu Trp Lys

675 680 685

Phe Ala Arg Ala Lys Leu Trp Leu Ser Tyr Phe Asp Glu Gly Arg Thr

690 695 700

Leu Pro Ala Pro Phe Asn Leu Val Pro Ser Pro Lys Ser Phe Tyr Tyr

705 710 715 720

Leu Ile Met Arg Ile Lys Met Cys Leu Ile Lys Leu Cys Lys Ser Lys

725 730 735

Ala Lys Ser Cys Glu Asn Asp Leu Glu Met Gly Met Leu Asn Ser Lys

740 745 750

Phe Lys Lys Thr Arg Tyr Gln Ala Gly Met Arg Asn Ser Glu Asn Leu

755 760 765

Thr Ala Asn Asn Thr Leu Ser Lys Pro Thr Arg Tyr Gln Lys Ile Met

770 775 780

Lys Arg Leu Ile Lys Arg Tyr Val Leu Lys Ala Gln Val Asp Arg Glu

785 790 795 800

Asn Asp Glu Val Asn Glu Gly Glu Leu Lys Glu Ile Lys Gln Asp Ile

805 810 815

Ser Ser Leu Arg Tyr Glu Leu Leu Glu Glu Lys Ser Gln Ala Thr Gly

820 825 830

Glu Leu Ala Asp Leu Ile Gln Gln Leu Ser Glu Lys Phe Gly Lys Asn

835 840 845

Leu Asn Lys Asp His Leu Arg Val Asn Lys Gly Lys Asp Ile

850 855 860

<210>69

<211>1265

<212>PRT

<213>智人(Homo sapiens)

<400>69

Met Lys Val Arg Leu Leu Arg Gln Leu Ser Ala Ala Ala Lys Val Lys

1 5 10 15

Ala Pro Ser Gly Leu Gln Gly Pro Pro Gln Ala His Gln Phe Ile Ser

20 25 30

Leu Leu Leu Glu Glu Tyr Gly Ala Leu Cys Gln Ala Ala Arg Ser Ile

35 40 45

Ser Thr Phe Leu Gly Thr Leu Glu Asn Glu His Leu Lys Lys Phe Gln

50 55 60

Val Thr Trp Glu Leu His Asn Lys His Leu Phe Glu Asn Leu Val Phe

65 70 75 80

Ser Glu Pro Leu Leu Gln Ser Asn Leu Pro Ala Leu Val Ser Gln Ile

85 90 95

Arg Leu Gly Thr Thr Thr His Asp Thr Cys Ser Glu Asp Thr Tyr Ser

100 105 110

Thr Leu Leu Gln Arg Tyr Gln Arg Ser Glu Glu Glu Leu Arg Arg Val

115 120 125

Ala Glu Glu Trp Leu Glu Cys Gln Lys Arg Ile Asp Ala Tyr Val Asp

130 135 140

Glu Gln Met Thr Met Lys Thr Lys Gln Arg Met Leu Thr Glu Asp Trp

145 150 155 160

Glu Leu Phe Lys Gln Arg Arg Phe Ile Glu Glu Gln Leu Thr Asn Lys

165 170 175

Lys Ala Val Thr Gly Glu Asn Asn Phe Thr Asp Thr Met Arg His Val

180 185 190

Leu Ser Ser Arg Leu Ser Met Pro Asp Cys Pro Asn Cys Asn Tyr Arg

195 200 205

Arg Arg Cys Ala Cys Asp Asp Cys Ser Leu Ser His Ile Leu Thr Cys

210 215 220

Gly Ile Met Asp Pro Pro Val Thr Asp Asp Ile His Ile His Gln Leu

225 230 235 240

Pro Leu Gln Val Asp Pro Ala Pro Asp Tyr Leu Ala Glu Arg Ser Pro

245 250 255

Pro Ser Val Ser Ser Ala Ser Ser Gly Ser Gly Ser Ser Ser Pro Ile

260 265 270

Thr Ile Gln Gln His Pro Arg Leu Ile Leu Thr Asp Ser Gly Ser Ala

275 280 285

Pro Thr Phe Cys Ser Asp Asp Glu Asp Val Ala Pro Leu Ser Ala Lys

290 295 300

Phe Ala Asp Ile Tyr Pro Leu Ser Asn Tyr Asp Asp Thr Glu Val Val

305 310 315 320

Ala Asn Met Asn Gly Ile His Ser Glu Leu Asn Gly Gly Gly Glu Asn

325 330 335

Met Ala Leu Lys Asp Glu Ser Pro Gln Ile Ser Ser Thr Ser Ser Ser

340 345 350

Ser Ser Glu Ala Asp Asp Glu Glu Ala Asp Gly Glu Ser Ser Gly Glu

355 360 365

Pro Pro Gly Ala Pro Lys Glu Asp Gly Val Leu Gly Ser Arg Ser Pro

370 375 380

Arg Thr Glu Glu Ser Lys Ala Asp Ser Pro Pro Pro Ser Tyr Pro Thr

385 390 395 400

Gln Gln Ala Glu Gln Ala Pro Asn Thr Cys Glu Cys His Val Cys Lys

405 410 415

Gln Glu Ala Ser Gly Leu Thr Pro Ser Ala Met Thr Ala Gly Ala Leu

420 425 430

Pro Pro Gly His Gln Phe Leu Ser Pro Glu Lys Pro Thr His Pro Ala

435 440 445

Leu His Leu Tyr Pro His Ile His Gly His Val Pro Leu His Thr Val

450 455 460

Pro His Leu Pro Arg Pro Leu Ile His Pro Thr Leu Tyr Ala Thr Pro

465 470 475 480

Pro Phe Thr His Ser Lys Ala Leu Pro Pro Ala Pro Val Gln Asn His

485 490 495

Thr Asn Lys His Gln Val Phe Asn Ala Ser Leu Gln Asp His Ile Tyr

500 505 510

Pro Ser Cys Phe Gly Asn Thr Pro Glu Trp Asn Ser Ser Lys Phe Ile

515 520 525

Ser Leu Trp Gly Ser Glu Val Met Asn Asp Lys Asn Trp Asn Pro Gly

530 535 540

Thr Phe Leu Pro Asp Thr Ile Ser Gly Ser Glu Ile Leu Gly Pro Thr

545 550 555 560

Leu Ser Glu Thr Arg Pro Glu Ala Leu Pro Pro Pro Ser Ser Asn Glu

565 570 575

Thr Pro Ala Val Ser Asp Ser Lys Glu Lys Lys Asn Ala Ala Lys Lys

580 585 590

Lys Cys Leu Tyr Asn Phe Gln Asp Ala Phe Met Glu Ala Asn Lys Val

595 600 605

Val Met Ala Thr Ser Ser Ala Thr Ser Ser Val Ser Cys Thr Ala Thr

6l0 615 620

Thr Val Gln Ser Ser Asn Ser Gln Phe Arg Val Ser Ser Lys Arg Pro

625 630 635 640

Pro Ser Val Gly Asp Val Phe His Gly Ile Ser Lys Glu Asp His Arg

645 650 655

His Ser Ala Pro Ala Ala Pro Arg Asn Ser Pro Thr Gly Leu Ala Pro

660 665 670

Leu Pro Ala Leu Ser Pro Ala Ala Leu Ser Pro Ala Ala Leu Ser Pro

675 680 685

Ala Ser Thr Pro His Leu Ala Ash Leu Ala Ala Pro Ser Phe Pro Lys

690 695 700

Thr Ala Thr Thr Thr Pro Gly Phe Val Asp Thr Arg Lys Ser Phe Cys

705 710 715 720

Pro Ala Pro Leu Pro Pro Ala Thr Asp Gly Ser Ile Ser Ala Pro Pro

725 730 735

Ser Val Cys Ser Asp Pro Asp Cys Glu Gly His Arg Cys Glu Asn Gly

740 745 750

Val Tyr Asp Pro Gln Gln Asp Asp Gly Asp Glu Ser Ala Asp Glu Asp

755 760 765

Ser Cys Ser Glu His Ser Ser Ser Thr Ser Thr Ser Thr Asn Gln Lys

770 775 780

Glu Gly Lys Tyr Cys Asp Cys Cys Tyr Cys Glu Phe Phe Gly His Gly

785 790 795 800

Gly Pro Pro Ala Ala Pro Thr Ser Arg Asn Tyr Ala Glu Met Arg Glu

805 810 815

Lys Leu Arg Leu Arg Leu Thr Lys Arg Lys Glu Glu Gln Pro Lys Lys

820 825 830

Met Asp Gln Ile Ser Glu Arg Glu Ser Val Val Asp His Arg Arg Val

835 840 845

Glu Asp Leu Leu Gln Phe Ile Asn Ser Ser Glu Thr Lys Pro Val Ser

850 855 860

Ser Thr Arg Ala Ala Lys Arg Ala Arg His Lys Gln Arg Lys Leu Glu

865 870 875 880

Glu Lys Ala Arg Leu Glu Ala Glu Ala Arg Ala Arg Glu His Leu His

885 890 895

Leu Gln Glu Glu Gln Arg Arg Arg Glu Glu Glu Glu Asp Glu Glu Glu

900 905 910

Glu Glu Asp Arg Phe Lys Glu Glu Phe Gln Arg Leu Gln Glu Leu Gln

915 920 925

Lys Leu Arg Ala Val Lys Lys Lys Lys Lys Glu Arg Pro Ser Lys Asp

930 935 940

Cys Pro Lys Leu Asp Met Leu Thr Arg Asn Phe Gln Ala Ala Thr Glu

945 950 955 960

Ser Val Pro Asn Ser Gly Asn Ile His Asn Gly Ser Leu Glu Gln Thr

965 970 975

Glu Glu Pro Glu Thr Ser Ser His Ser Pro Ser Arg His Met Asn His

980 985 990

Ser Glu Pro Arg Pro Gly Leu Gly Ala Asp Gly Asp Ala Ala Asp Pro

995 1000 1005

Val Asp Thr Arg Asp Ser Lys Phe Leu Leu Pro Lys Glu Val Asn Gly

1010 1015 1020

Lys Gln His Glu Pro Leu Ser Phe Phe Phe Asp Ile Met Gln His His

1025 1030 1035 1040

Lys Glu Gly Asn Gly Lys Gln Lys Leu Arg Gln Thr Ser Lys Ala Ser

1045 1050 1055

Ser Glu Pro Ala Arg Arg Pro Thr Glu Pro Pro Lys Ala Thr Glu Gly

1060 1065 1070

Gln Ser Lys Pro Arg Ala Gln Thr Glu Ser Lys Ala Lys Val Val Asp

1075 1080 1085

Leu Met Ser Ile Thr Glu Gln Lys Arg Glu Glu Arg Lys Val Asn Ser

1090 1095 1100

Asn Asn Asn Asn Lys Lys Gln Leu Asn His Ile Lys Asp Glu Lys Ser

1105 1110 1115 1120

Asn Pro Thr Pro Met Glu Pro Thr Ser Pro Gly Glu His Gln Gln Asn

1125 1130 1135

Ser Lys Leu Val Leu Ala Glu Ser Pro Gln Pro Lys Gly Lys Asn Lys

1140 1145 1150

Lys Asn Lys Lys Lys Lys Gly Asp Arg Val Asn Asn Ser Ile Asp Gly

1155 1160 1165

Val Ser Leu Leu Leu Pro Ser Leu Gly Tyr Asn Gly Ala Ile Leu Ala

1170 1175 1180

His Cys Asn Leu Arg Leu Pro Gly Ser Ser Asp Cys Ala Ala Ser Ala

1185 1190 1195 1200

Ser Gln Val Val Gly Ile Thr Asp Asp Val Phe Leu Pro Lys Asp Ile

1205 1210 1215

Asp Leu Asp Ser Val Asp Met Asp Glu Thr Glu Arg Glu Val Glu Tyr

1220 1225 1230

Phe Lys Arg Phe Cys Leu Asp Ser Ala Arg Gln Thr Arg Gln Arg Leu

1235 1240 1245

Ser Ile Asn Trp Ser Asn Phe Ser Leu Lys Lys Ala Thr Phe Ala Ala

1250 1255 1260

His

1265

<210>70

<211>392

<212>PRT

<213>智人(Homo sapiens)

<400>70

Met Gly Ser Leu Ser Thr Ala Asn Val Glu Phe Cys Leu Asp Val Phe

1 5 10 15

Lys Glu Leu Asn Ser Asn Asn Ile Gly Asp Asn Ile Phe Phe Ser Ser

20 25 30

Leu Ser Leu Leu Tyr Ala Leu Ser Met Val Leu Leu Gly Ala Arg Gly

35 40 45

Glu Thr Ala Glu Gln Leu Glu Lys Val Leu His Phe Ser His Thr Val

50 55 60

Asp Ser Leu Lys Pro Gly Phe Lys Asp Ser Pro Lys Cys Ser Gln Ala

65 70 75 80

Gly Arg Ile His Ser Glu Phe Gly Val Glu Phe Ser Gln Ile Asn Gln

85 90 95

Pro Asp Ser Asn Cys Thr Leu Ser Ile Ala Asn Arg Leu Tyr Gly Thr

100 105 110

Lys Thr Met Ala Phe His Gln Gln Tyr Leu Ser Cys Ser Glu Lys Trp

115 120 125

Tyr Gln Ala Arg Leu Gln Thr Val Asp Phe Glu Gln Ser Thr Glu Glu

130 135 140

Thr Arg Lys Met Ile Asn Ala Trp Val Glu Asn Lys Thr Asn Gly Lys

145 150 155 160

Val Ala Asn Leu Phe Gly Lys Ser Thr Ile Asp Pro Ser Ser Val Met

165 170 175

Val Leu Val Asn Ile Ile Tyr Phe Lys Gly Gln Arg Gln Asn Lys Phe

180 185 190

Gln Val Arg Glu Thr Val Lys Ser Pro Phe Gln Leu Ser Glu Gly Lys

195 200 205

Asn Val Thr Val Glu Met Met Tyr Gln Ile Gly Thr Phe Lys Leu Ala

210 215 220

Phe Val Lys Glu Pro Gln Met Gln Val Leu Glu Leu Pro Tyr Val Asn

225 230 235 240

Asn Lys Leu Ser Met Ile Ile Leu Leu Pro Val Gly Ile Ala Asn Leu

245 250 255

Lys Gln Ile Glu Lys Gln Leu Asn Ser Gly Thr Phe His Glu Trp Thr

260 265 270

Ser Ser Ser Asn Met Met Glu Arg Glu Val Glu Val His Leu Pro Arg

275 280 285

Phe Lys Leu Glu Ile Lys Tyr Glu Leu Asn Ser Leu Leu Lys Pro Leu

290 295 300

Gly Val Thr Asp Leu Phe Asn Gln Val Lys Ala Asp Leu Ser Gly Met

305 310 315 320

Ser Pro Thr Lys Gly Leu Tyr Leu Ser Lys Ala Ile His Lys Ser Tyr

325 330 335

Leu Asp Val Ser Glu Glu Gly Thr Glu Ala Ala Ala Ala Thr Gly Asp

340 345 350

Ser Ile Ala Val Lys Ser Leu Pro Met Arg Ala Gln Phe Lys Ala Asn

355 360 365

His Pro Phe Leu Phe Phe Ile Arg His Thr His Thr Asn Thr Ile Leu

370 375 380

Phe Cys Gly Lys Leu Ala Ser Pro

385 390

<210>71

<211>793

<212>PRT

<213>智人(Homo sapiens)

<400>71

Met Met Ala Ala Leu Tyr Pro Ser Thr Asp Leu Ser Gly Ala Ser Ser

1 5 10 15

Ser Ser Leu Pro Ser Ser Pro Ser Ser Ser Ser Pro Asn Glu Val Met

20 25 30

Ala Leu Lys Asp Val Arg Glu Val Lys Glu Glu Asn Thr Leu Asn Glu

35 40 45

Lys Leu Phe Leu Leu Ala Cys Asp Lys Gly Asp Tyr Tyr Met Val Lys

50 55 60

Lys Ile Leu Glu Glu Asn Ser Ser Gly Asp Leu Asn Ile Asn Cys Val

65 70 75 80

Asp Val Leu Gly Arg Asn Ala Val Thr Ile Thr Ile Glu Asn Glu Asn

85 90 95

Leu Asp Ile Leu Gln Leu Leu Leu Asp Tyr Gly Cys Gln Ser Ala Asp

100 105 110

Ala Leu Leu Val Ala Ile Asp Ser Glu Val Val Gly Ala Val Asp Ile

115 120 125

Leu Leu Asn His Arg Pro Lys Arg Ser Ser Arg Pro Thr Ile Val Lys

130 135 140

Leu Met Glu Arg Ile Gln Asn Pro Glu Tyr Ser Thr Thr Met Asp Val

145 150 155 160

Ala Pro Val Ile Leu Ala Ala His Arg Asn Asn Tyr Glu Ile Leu Thr

165 170 175

Met Leu Leu Lys Gln Asp Val Ser Leu Pro Lys Pro His Ala Val Gly

180 185 190

Cys Glu Cys Thr Leu Cys Ser Ala Lys Asn Lys Lys Asp Ser Leu Arg

195 200 205

His Ser Arg Phe Arg Leu Asp Ile Tyr Arg Cys Leu Ala Ser Pro Ala

2l0 215 220

Leu Ile Met Leu Thr Glu Glu Asp Pro Ile Leu Arg Ala Phe Glu Leu

225 230 235 240

Ser Ala Asp Leu Lys Glu Leu Ser Leu Val Glu Val Glu Phe Arg Asn

245 250 255

Asp Tyr Glu Glu Leu Ala Arg Gln Cys Lys Met Phe Ala Lys Asp Leu

260 265 270

Leu Ala Gln Ala Arg Asn Ser Arg Glu Leu Glu Val Ile Leu Asn His

275 280 285

Thr Ser Ser Asp Glu Pro Leu Asp Lys Arg Gly Leu Leu Glu Glu Arg

290 295 300

Met Asn Leu Ser Arg Leu Lys Leu Ala Ile Lys Tyr Asn Gln Lys Glu

305 310 315 320

Phe Val Ser Gln Ser Asn Cys Gln Gln Phe Leu Asn Thr Val Trp Phe

325 330 335

Gly Gln Met Ser Gly Tyr Arg Arg Lys Pro Thr Cys Lys Lys Ile Met

340 345 350

Thr Val Leu Thr Val Gly Ile Phe Trp Pro Val Leu Ser Leu Cys Tyr

355 360 365

Leu Ile Ala Pro Lys Ser Gln Phe Gly Arg Ile Ile His Thr Pro Phe

370 375 380

Met Lys Phe Ile Ile His Gly Ala Ser Tyr Phe Thr Phe Leu Leu Leu

385 390 395 400

Leu Asn Leu Tyr Ser Leu Val Tyr Asn Glu Asp Lys Lys Asn Thr Met

405 410 415

Gly Pro Ala Leu Glu Arg Ile Asp Tyr Leu Leu Ile Leu Trp Ile Ile

420 425 430

Gly Met Ile Trp Ser Asp Ile Lys Arg Leu Trp Tyr Glu Gly Leu Glu

435 440 445

Asp Phe Leu Glu Glu Ser Arg Asn Gln Leu Ser Phe Val Met Asn Ser

450 455 460

Leu Tyr Leu Ala Thr Phe Ala Leu Lys Val Val Ala His Asn Lys Phe

465 470 475 480

His Asp Phe Ala Asp Arg Lys Asp Trp Asp Ala Phe His Pro Thr Leu

485 490 495

Val Ala Glu Gly Leu Phe Ala Phe Ala Asn Val Leu Ser Tyr Leu Arg

500 505 510

Leu Phe Phe Met Tyr Thr Thr Ser Ser Ile Leu Gly Pro Leu Gln Ile

515 520 525

Ser Met Gly Gln Met Leu Gln Asp Phe Gly Lys Phe Leu Gly Met Phe

530 535 540

Leu Leu Val Leu Phe Ser Phe Thr Ile Gly Leu Thr Gln Leu Tyr Asp

545 550 555 560

Lys Gly Tyr Thr Ser Lys Glu Gln Lys Asp Cys Val Gly Ile Phe Cys

565 570 575

Glu Gln Gln Ser Asn Asp Thr Phe His Ser Phe Ile Gly Thr Cys Phe

580 585 590

Ala Leu Phe Trp Tyr Ile Phe Ser Leu Ala His Val Ala Ile Phe Val

595 600 605

Thr Arg Phe Ser Tyr Gly Glu Glu Leu Gln Ser Phe Val Gly Ala Val

610 615 620

Ile Val Gly Thr Tyr Asn Val Val Val Val Ile Val Leu Thr Lys Leu

625 630 635 640

Leu Val Ala Met Leu His Lys Ser Phe Gln Leu Ile Ala Asn His Glu

645 650 655

Asp Lys Glu Trp Lys Phe Ala Arg Ala Lys Leu Trp Leu Ser Tyr Phe

660 665 670

Asp Asp Lys Cys Thr Leu Pro Pro Pro Phe Asn Ile Ile Pro Ser Pro

675 680 685

Lys Thr Ile Cys Tyr Met Ile Ser Ser Leu Ser Lys Trp Ile Cys Ser

690 695 700

His Thr Ser Lys Gly Lys Val Lys Arg Gln Asn Ser Leu Lys Glu Trp

705 710 715 720

Arg Asn Leu Lys Gln Lys Arg Asp Glu Asn Tyr Gln Lys Val Met Cys

725 730 735

Cys Leu Val His Arg Tyr Leu Thr Ser Met Arg Gln Lys Met Gln Ser

740 745 750

Thr Asp Gln Ala Thr Val Glu Asn Leu Asn Glu Leu Arg Gln Asp Leu

755 760 765

Ser Lys Phe Arg Asn Glu Ile Arg Asp Leu Leu Gly Phe Arg Thr Ser

770 775 780

Lys Tyr Ala Met Phe Tyr Pro Arg Asn

785 790

<210>72

<211>982

<212>PRT

<213>智人(Homo sapiens)

<400>72

Met Ala Gln Phe Tyr Tyr Lys Arg Asn Val Asn Ala Pro Tyr Arg Asp

1 5 10 15

Arg Ile Pro Leu Arg Ile Val Arg Ala Glu Ser Glu Leu Ser Pro Ser

20 25 30

Glu Lys Ala Tyr Leu Asn Ala Val Glu Lys Gly Asp Tyr Ala Ser Val

35 40 45

Lys Lys Ser Leu Glu Glu Ala Glu Ile Tyr Phe Lys Ile Asn Ile Asn

50 55 60

Cys Ile Asp Pro Leu Gly Arg Thr Ala Leu Leu Ile Ala Ile Glu Asn

65 70 75 80

Glu Asn Leu Glu Leu Ile Glu Leu Leu Leu Ser Phe Asn Val Tyr Val

85 90 95

Gly Asp Ala Leu Leu His Ala Ile Arg Lys Glu Val Val Gly Ala Val

100 105 110

Glu Leu Leu Leu Asn His Lys Lys Pro Ser Gly Glu Lys Gln Val Pro

115 120 125

Pro Ile Leu Leu Asp Lys Gln Phe Ser Glu Phe Thr Pro Asp Ile Thr

130 135 140

Pro Ile Ile Leu Ala Ala His Thr Asn Asn Tyr Glu Ile Ile Lys Leu

145 150 155 160

Leu Val Gln Lys Gly Val Ser Val Pro Arg Pro His Glu Val Arg Cys

165 170 175

Asn Cys Val Glu Cys Val Ser Ser Ser Asp Val Asp Ser Leu Arg His

180 185 190

Ser Arg Ser Arg Leu Asn Ile Tyr Lys Ala Leu Ala Ser Pro Ser Leu

195 200 205

Ile Ala Leu Ser Ser Glu Asp Pro Phe Leu Thr Ala Phe Gln Leu Ser

210 215 220

Trp Glu Leu Gln Glu Leu Ser Lys Val Glu Asn Glu Phe Lys Ser Glu

225 230 235 240

Tyr Glu Glu Leu Ser Arg Gln Cys Lys Gln Phe Ala Lys Asp Leu Leu

245 250 255

Asp Gln Thr Arg Ser Ser Arg Glu Leu Glu Ile Ile Leu Asn Tyr Arg

260 265 270

Asp Asp Asn Ser Leu Ile Glu Glu Gln Ser Gly Asn Asp Leu Ala Arg

275 280 285

Leu Lys Leu Ala Ile Lys Tyr Arg Gln Lys Glu Phe Val Ala Gln Pro

290 295 300

Asn Cys Gln Gln Leu Leu Ala Ser Arg Trp Tyr Asp Glu Phe Pro Gly

305 310 315 320

Trp Arg Arg Arg His Trp Ala Val Lys Met Val Thr Cys Phe Ile Ile

325 330 335

Gly Leu Leu Phe Pro Val Phe Ser Val Cys Tyr Leu Ile Ala Pro Lys

340 345 350

Ser Pro Leu Gly Leu Phe Ile Arg Lys Pro Phe Ile Lys Phe Ile Cys

355 360 365

His Thr Ala Ser Tyr Leu Thr Phe Leu Phe Leu Leu Leu Leu Ala Ser

370 375 380

Gln His Ile Asp Arg Ser Asp Leu Asn Arg Gln Gly Pro Pro Pro Thr

385 390 395 400

Ile Val Glu Trp Met Ile Leu Pro Trp Val Leu Gly Phe Ile Trp Gly

405 410 415

Glu Ile Lys Gln Met Trp Asp Gly Gly Leu Gln Asp Tyr Ile His Asp

420 425 430

Trp Trp Asn Leu Met Asp Phe Val Met Asn Ser Leu Tyr Leu Ala Thr

435 440 445

Ile Ser Leu Lys Ile Val Ala Phe Val Lys Tyr Ser Ala Leu Asn Pro

450 455 460

Arg Glu Ser Trp Asp Met Trp His Pro Thr Leu Val Ala Glu Ala Leu

465 470 475 480

Phe Ala Ile Ala Asn Ile Phe Ser Ser Leu Arg Leu Ile Ser Leu Phe

485 490 495

Thr Ala Asn Ser His Leu Gly Pro Leu Gln Ile Ser Leu Gly Arg Met

500 505 510

Leu Leu Asp Ile Leu Lys Phe Leu Phe Ile Tyr Cys Leu Val Leu Leu

515 520 525

Ala Phe Ala Asn Gly Leu Asn Gln Leu Tyr Phe Tyr Tyr Glu Glu Thr

530 535 540

Lys Gly Leu Thr Cys Lys Gly Ile Arg Cys Glu Lys Gln Asn Asn Ala

545 550 555 560

Phe Ser Thr Leu Phe Glu Thr Leu Gln Ser Leu Phe Trp Ser Ile Phe

565 570 575

Gly Leu Ile Asn Leu Tyr Val Thr Asn Val Lys Ala Gln His Glu Phe

580 585 590

Thr Glu Phe Val Gly Ala Thr Met Phe Gly Thr Tyr Asn Val Ile Ser

595 600 605

Leu Val Val Leu Leu Asn Met Leu Ile Ala Met Met Asn Asn Ser Tyr

610 615 620

Gln Leu Ile Ala Asp His Ala Asp Ile Glu Trp Lys Phe Ala Arg Thr

625 630 635 640

Lys Leu Trp Met Ser Tyr Phe Glu Glu Gly Gly Thr Leu Pro Thr Pro

645 650 655

Phe Asn Val Ile Pro Ser Pro Lys Ser Leu Trp Tyr Leu Ile Lys Trp

660 665 670

Ile Trp Thr His Leu Cys Lys Lys Lys Met Arg Arg Lys Pro Glu Ser

675 680 685

Phe Gly Thr Ile Gly Val Arg Thr Gln His Arg Arg Ala Ala Asp Asn

690 695 700

Leu Arg Arg His His Gln Tyr Gln Val Ile Met Arg Asn Leu Val Lys

705 710 715 720

Arg Tyr Val Ala Ala Met Ile Arg Asp Ala Lys Thr Glu Glu Gly Leu

725 730 735

Thr Glu Glu Asn Phe Lys Glu Leu Lys Gln Asp Ile Ser Ser Phe Arg

740 745 750

Phe Glu Val Leu Gly Leu Leu Arg Gly Ser Lys Leu Ser Thr Ile Gln

755 760 755

Ser Ala Asn Ala Ser Lys Glu Ser Ser Asn Ser Ala Asp Ser Asp Glu

770 775 780

Lys Ser Asp Ser Glu Gly Asn Ser Lys Asp Lys Lys Lys Asn Phe Ser

785 790 795 800

Leu Phe Asp Leu Thr Thr Leu Ile His Pro Arg Ser Ala Ala Ile Ala

805 810 815

Ser Glu Arg His Asn Ile Ser Asn Gly Ser Ala Leu Mal Val Gln Glu

820 825 830

Pro Pro Arg Glu Lys Gln Arg Lys Val Asn Phe Val Thr Asp Ile Lys

835 840 845

Asn Phe Gly Leu Phe His Arg Arg Ser Lys Gln Asn Ala Ala Glu Gln

850 855 860

Asn Ala Asn Gln Ile Phe Ser Val Ser Glu Glu Val Ala Arg Gln Gln

865 870 875 880

Ala Ala Gly Pro Leu Glu Arg Asn Ile Gln Leu Glu Ser Arg Gly Leu

885 890 895

Ala Ser Arg Gly Asp Leu Ser Ile Pro Gly Leu Ser Glu Gln Cys Val

900 905 910

Leu Val Asp His Arg Glu Arg Asn Thr Asp Thr Leu Gly Leu Gln Val

915 920 925

Gly Lys Arg Val Cys Pro Phe Lys Ser Glu Lys Val Val Val Glu Asp

930 935 940

Thr Val Pro Ile Ile Pro Lys Glu Lys His Ala Lys Glu Glu Asp Ser

945 950 955 960

Ser Ile Asp Tyr Asp Leu Asn Leu Pro Asp Thr Val Thr His Glu Asp

965 970 975

Tyr Val Thr Thr Arg Leu

980

<210>73

<211>930

<212>PRT

<213>小家鼠(Mus musculus)

<400>73

Met Ser Gln Ser Pro Arg Phe Val Thr Arg Arg Gly Gly Ser Leu Lys

1 5 10 15

Ala Ala Pro Gly Ala Gly Thr Arg Arg Asn Glu Ser Gln Asp Tyr Leu

20 25 30

Leu Met Asp Glu Leu Gly Asp Asp Gly Tyr Pro Gln Leu Pro Leu Pro

35 40 45

Pro Tyr Gly Tyr Tyr Pro Ser Phe Arg Gly Asn Glu Asn Arg Leu Thr

50 55 60

His Arg Arg Gln Thr Ile Leu Arg Glu Lys Gly Arg Arg Leu Ala Asn

65 70 75 80

Arg Gly Pro Ala Tyr Met Phe Asn Asp His Ser Thr Ser Leu Ser Ile

85 90 95

Glu Glu Glu Arg Phe Leu Asp Ala Ala Glu Tyr Gly Asn Ile Pro Val

100 105 110

Val Arg Lys Met Leu Glu Glu Cys His Ser Leu Asn Val Asn Cys Val

115 120 125

Asp Tyr Met Gly Gln Asn Ala Leu Gln Leu Ala Val Ala Asn Glu His

130 135 140

Leu Glu Ile Thr Glu Leu Leu Leu Lys Lys Glu Asn Leu Ser Arg Val

145 150 155 160

Gly Asp Ala Leu Leu Leu Ala Ile Ser Lys Gly Tyr Val Arg Ile Val

165 170 175

Glu Ala Ile Leu Asn His Pro Ala Phe Ala Glu Gly Lys Arg Leu Ala

180 185 190

Thr Ser Pro Ser Gln Ser Glu Leu Gln Gln Asp Asp Phe Tyr Ala Tyr

195 200 205

Asp Glu Asp Gly Thr Arg Phe Ser His Asp Val Thr Pro Ile Ile Leu

210 215 220

Ala Ala His Cys Gln Glu Tyr Glu Ile Val His Thr Leu Leu Arg Lys

225 230 235 240

Gly Ala Arg Ile Glu Arg Pro His Asp Tyr Phe Cys Lys Cys Thr Glu

245 250 255

Cys Ser Gln Lys Gln Lys His Asp Ser Phe Ser His Ser Arg Ser Arg

260 265 270

Ile Asn Ala Tyr Lys Gly Leu Ala Ser Pro Ala Tyr Leu Ser Leu Ser

275 280 285

Ser Glu Asp Pro Val Met Thr Ala Leu Glu Leu Ser Asn Glu Leu Ala

290 295 300

Val Leu Ala Asn Ile Glu Lys Glu Phe Lys Asn Asp Tyr Arg Lys Leu

305 310 315 320

Ser Met Gln Cys Lys Asp Phe Val Val Gly Leu Leu Asp Leu Cys Arg

325 330 335

Asn Thr Glu Glu Val Glu Ala Ile Leu Asn Gly Asp Ala Glu Thr Arg

340 345 350

Gln Pro Gly Asp Phe Gly Arg Pro Asn Leu Ser Arg Leu Lys Leu Ala

355 360 365

Ile Lys Tyr Glu Val Lys Lys Phe Val Ala His Pro Asn Cys Gln Gln

370 375 380

Gln Leu Leu Ser Ile Trp Tyr Glu Asn Leu Ser Gly Leu Arg Gln Gln

385 390 395 400

Thr Met Ala Val Lys Phe Leu Val Val Leu Ala Val Ala Ile Gly Leu

405 410 415

Pro Phe Leu Ala Leu Ile Tyr Trp Cys Ala Pro Cys Ser Lys Met Gly

420 425 430

Lys Ile Leu Arg Gly Pro Phe Met Lys Phe Val Ala His Ala Ala Ser

435 440 445

Phe Thr Ile Phe Leu Gly Leu Leu Val Met Asn Ala Ala Asp Arg Phe

450 455 460

Glu Gly Thr Lys Leu Leu Pro Asn Glu Thr Ser Thr Asp Asn Ala Arg

465 470 475 480

Gln Leu Phe Arg Met Lys Thr Ser Cys Phe Ser Trp Met Glu Met Leu

485 490 495

Ile Ile Ser Trp Val Ile Gly Met Ile Trp Ala Glu Cys Lys Glu Ile

500 505 510

Trp Thr Gln Gly Pro Lys Glu Tyr Leu Phe Glu Leu Trp Asn Met Leu

515 520 525

Asp Phe Gly Met Leu Ala Ile Phe Ala Ala Ser Phe Ile Ala Arg Phe

530 535 540

Met Ala Phe Trp His Ala Ser Lys Ala Gln Ser Ile Ile Asp Ala Asn

545 550 555 560

Asp Thr Leu Lys Asp Leu Thr Lys Val Thr Leu Gly Asp Asn Val Lys

565 570 575

Tyr Tyr Asn Leu Ala Arg Ile Lys Trp Asp Pro Thr Asp Pro Gln Ile

580 585 590

Ile Ser Glu Gly Leu Tyr Ala Ile Ala Val Val Leu Ser Phe Ser Arg

595 600 605

Ile Ala Tyr Ile Leu Pro Ala Asn Glu Ser Phe Gly Pro Leu Gln Ile

610 615 620

Ser Leu Gly Arg Thr Val Lys Asp Ile Phe Lys Phe Met Val Ile Phe

625 630 635 640

Ile Met Val Phe Val Ala Phe Met Ile Gly Met Phe Asn Leu Tyr Ser

645 650 655

Tyr Tyr Ile Gly Ala Lys Gln Asn Glu Ala Phe Thr Thr Val Glu Glu

660 665 670

Ser Phe Lys Thr Leu Phe Trp Ala Ile Phe Gly Leu Ser Glu Val Lys

675 680 685

Ser Val Val Ile Asn Tyr Asn His Lys Phe Ile Glu Asn Ile Gly Tyr

690 695 700

Val Leu Tyr Gly Val Tyr Asn Val Thr Met Val Ile Val Leu Leu Asn

705 710 715 720

Met Leu Ile Ala Met Ile Asn Ser Ser Phe Gln Glu Ile Glu Asp Asp

725 730 735

Ala Asp Val Glu Trp Lys Phe Ala Arg Ala Lys Leu Trp Phe Ser Tyr

740 745 750

Phe Glu Glu Gly Arg Thr Leu Pro Val Pro Phe Asn Leu Val Pro Ser

755 760 765

Pro Lys Ser Leu Leu Tyr Leu Leu Leu Lys Phe Lys Lys Trp Met Cys

770 775 780

Glu Leu Ile Gln Gly Gln Lys Gln Gly Phe Gln Glu Asp Ala Glu Met

785 790 795 800

Asn Lys Arg Asn Glu Glu Lys Lys Phe Gly Ile Ser Gly Ser His Glu

805 810 815

Asp Leu Ser Lys Phe Ser Leu Asp Lys Asn Gln Leu Ala His Asn Lys

820 825 830

Gln Ser Ser Thr Arg Ser Ser Glu Asp Tyr His Leu Asn Ser Phe Ser

835 840 845

Asn Pro Pro Arg Gln Tyr Gln Lys Ile Met Lys Arg Leu Ile Lys Arg

850 855 860

Tyr Val Leu Gln Ala Gln Ile Asp Lys Glu Ser Asp Glu Val Asn Glu

865 870 875 880

Gly Glu Leu Lys Glu Ile Lys Gln Asp Ile Ser Ser Leu Arg Tyr Glu

885 890 895

Leu Leu Glu Glu Lys Ser Gln Asn Thr Glu Asp Leu Ala Glu Leu Ile

900 905 910

Arg Lys Leu Gly Glu Arg Leu Ser Leu Glu Pro Lys Leu Glu Glu Ser

915 920 925

Arg Arg

930

<210>74

<211>826

<212>PRT

<213>智人(Homo sapiens)

<400>74

Pro Ser Gly Leu Pro Leu Leu Pro Val Leu Phe Ala Leu Gly Gly Leu

1 5 10 15

Leu Leu Leu Ser Asn Ala Ser Cys Val Gly Gly Val Leu Trp Gln Arg

20 25 30

Arg Leu Arg Arg Leu Ala Glu Ala Leu Asn Phe Pro Pro His Leu His

35 40 45

Pro Gly Arg Ser Glu Glu Asp Arg Val Arg Asn Glu Tyr Glu Glu Ser

50 55 60

Gln Trp Thr Gly Glu Arg Asp Thr Gln Ser Ser Thr Val Ser Thr Thr

65 70 75 80

Glu Ala Glu Pro Tyr Tyr Arg Ser Leu Arg Asp Phe Ser Pro Gln Leu

85 90 95

Pro Pro Thr Gln Glu Glu Val Ser Tyr Ser Arg Gly Phe Thr Gly Glu

100 105 110

Asp Glu Asp Met Ala Phe Pro Gly His Leu Tyr Asp Glu Val Glu Arg

115 120 125

Thr Tyr Pro Pro Ser Gly Ala Trp Gly Pro Leu Tyr Asp Glu Val Gln

130 135 140

Met Gly Pro Trp Asp Leu His Trp Pro Glu Asp Thr Tyr Gln Asp Pro

145 150 155 160

Arg Gly Ile Tyr Asp Gln Val Ala Gly Asp Leu Asp Thr Leu Glu Pro

165 170 175

Asp Ser Leu Pro Phe Glu Leu Arg Gly His Leu Val Trp Gly Phe Asn

180 185 190

His Val Ser Gln Ala Gly Leu Lys Leu Leu Ala Ser Ser Asp Pro Pro

195 200 205

Ala Ser Ala Ser Gln Ser Ala Glu Ile Thr Glu Ser His Ser Val Val

210 215 220

Gln Val Gly Val Gln Trp Arg Tyr Phe Gly Ser Leu His Pro Leu Pro

225 230 235 240

Pro Gly Ser Arg Asp Ser Leu Ala Ser Ala Ser Arg Ile Ala Gly Ile

245 250 255

Thr Ala Pro Trp Glu Ala Glu Val Ser Arg Ser Pro Gln Gly Thr Gln

260 265 270

Asp Ser Pro Val Thr Arg Ser Gly Pro Pro Ser Arg Gly Trp Gln Ser

275 280 285

Leu Ser Phe Asp Gly Gly Ala Phe His Leu Lys Gly Thr Gly Glu Leu

290 295 300

Thr Arg Ala Leu Leu Val Leu Arg Leu Cys Ala Trp Pro Pro Leu Val

305 310 315 320

Thr His Gly Leu Leu Leu Gln Ala Trp Ser Arg Arg Leu Leu Gly Ser

325 330 335

Arg Leu Ser Gly Ala Phe Leu Arg Ala Ser Val Tyr Gly Gln Phe Val

340 345 350

Ala Gly Glu Thr Ala Glu Glu Val Lys Gly Cys Val Gln Gln Leu Arg

355 360 365

Thr Leu Ser Leu Arg Pro Leu Leu Ala Val Pro Thr Glu Glu Glu Pro

370 375 380

Asp Ser Ala Ala Lys Arg Met Arg Leu His His Val Gly Gln Ala Gly

385 390 395 400

Leu Glu Leu Leu Thr Pro Ala Ala Ser Gly Ser Val Ala Gln Ala Gly

405 410 415

Val Gln Trp Arg Gln Ser Ser Asp Arg Gly Gly Gly Asn Gln Ala Ala

420 425 430

Ala Ser Arg Ser Ser Leu Leu Gln Glu Ala Ala Phe Ser Pro Pro Cys

435 440 445

Gly Arg Leu Gln Leu Pro Ala Gln Pro Ala Ser Arg His Gly Ala Arg

450 455 460

Gly Arg Gly Ser Met Lys Ala Lys Ser Leu Thr Ser Arg His Leu Leu

465 470 475 480

Ala Ser Gln Gly Gln Glu Thr Ile Ile Lys Thr Lys Val Arg Ile Pro

485 490 495

Ala Leu Trp Lys Ala Glu Pro Gly Gln His Ser Lys Thr Pro Ser Gln

500 505 510

Gln Asn Lys Ser Gln Tyr Val Thr Thr Leu Trp Glu Ala Asp Val Gly

515 520 525

Arg Ser Leu Glu Asn Leu Gln Val Ser Cys Leu Asn Ala Glu Gln Asn

530 535 540

Gln His Leu Arg Ala Ser Leu Ser Arg Leu His Arg Val Thr Pro Pro

545 550 555 560

Ala Gly Thr Ser Thr Ser Gly Pro Pro Ser Ala Ala Cys Ile Gly Trp

565 570 575

His Ser Arg Leu His Arg Val Ala Gln Tyr Ala Arg Ala Gln His Val

580 585 590

Arg Leu Leu Val Asp Ala Glu Tyr Thr Ser Leu Asn Pro Ala Leu Ser

595 600 605

Leu Leu Val Ala Ala Leu Ala Val Arg Trp Asn Ser Pro Gly Glu Gly

610 615 620

Gly Pro Trp Val Trp Asn Thr Tyr Gln Ala Cys Leu Lys Asp Thr Phe

625 630 635 640

Glu Arg Leu Gly Arg Asp Ala Glu Ala Ala His Arg Ala Gly Leu Ala

645 650 655

Phe Gly Val Lys Leu Val Arg Gly Ala Tyr Leu Asp Lys Glu Arg Ala

660 665 670

Val Ala Gln Leu His Gly Met Glu Asp Pro Thr Gln Pro Asp Tyr Glu

675 680 685

Ala Thr Ser Glu Leu Asn Arg Ala Ser Pro Phe Ser Tyr Ser Arg Cys

690 695 700

Leu Glu Leu Met Leu Thr His Val Ala Arg His Gly Pro Met Cys His

705 710 715 720

Leu Met Val Ala Ser His Asn Glu Glu Ser Val Arg Gln Ala Thr Lys

725 730 735

Arg Met Trp Glu Leu Gly Ile Pro Leu Asp Gly Thr Val Cys Phe Gly

740 745 750

Gln Leu Leu Gly Met Cys Asp His Val Ser Leu Ala Leu Gly Gln Ala

755 760 765

Gly Tyr Val Val Tyr Lys Ser Ile Pro Tyr Gly Ser Leu Glu Glu Val

770 775 780

Ile Pro Tyr Leu Ile Arg Arg Ala Gln Glu Asn Arg Ser Val Leu Gln

785 790 795 800

Gly Ala Arg Arg Glu Gln Glu Leu Leu Ser Gln Glu Leu Trp Arg Arg

805 810 815

Leu Leu Pro Gly Cys Arg Arg Ile Pro His

820 825

<210>75

<211>39

<212>PRT

<213>智人(Homo sapiens)

<400>75

Ser Cys Ser Val Thr Leu Ala Gly Val Gln Trp Arg Asp Leu Gly Leu

1 5 10 15

Leu Gln Pro Leu Pro Pro Lys Phe Lys Arg Phe Ser Cys Leu Ser Phe

20 25 30

Pro Ser Ser Trp Asp Tyr Arg

35

<210>76

<211>46

<212>PRT

<213>智人(Homo sapiens)

<400>76

Glu Met Glu Phe Asn Cys Glu Ser Cys Ser Val Thr Leu Ala Gly Val

1 5 10 15

Gln Trp Arg Asp Leu Gly Leu Leu Gln Pro Leu Pro Pro Lys Phe Lys

20 25 30

Arg Phe Ser Cys Leu Ser Phe Pro Ser Ser Trp Asp Tyr Arg

35 40 45

<210>77

<211>810

<212>PRT

<213>智人(Homo sapiens)

<400>77

Met Cys Pro Gly Ile Pro Gly Pro Arg Ala Glu Ala Ala Val Gly Thr

1 5 10 15

Thr His Pro Phe Ser Ser Pro Gly Ala Trp Leu Gly Ser Gly Ser Gly

20 25 30

Ser Gly Pro Val Gly Ala Pro Pro Pro Ser Pro Gly Leu Pro Pro Ser

35 40 45

Trp Ala Ala Met Met Ala Ala Leu Tyr Pro Ser Thr Asp Leu Ser Gly

50 55 60

Ala Ser Ser Ser Ser Leu Pro Ser Ser Pro Ser Ser Ser Ser Pro Asn

65 70 75 80

Glu Val Met Ala Leu Lys Asp Val Arg Glu Val Lys Glu Glu Asn Thr

85 90 95

Leu Asn Glu Lys Leu Phe Leu Leu Ala Cys Asp Lys Gly Asp Tyr Tyr

100 105 110

Met Val Lys Lys Ile Leu Glu Glu Asn Ser Ser Gly Asp Leu Asn Ile

115 120 125

Asn Cys Val Asp Val Leu Gly Arg Asn Ala Val Thr Ile Thr Ile Glu

130 135 140

Asn Glu Asn Leu Asp Ile Leu Gln Leu Leu Leu Asp Tyr Gly Cys Gln

145 150 155 160

Lys Leu Met Glu Arg Ile Gln Asn Pro Glu Tyr Ser Thr Thr Met Asp

165 170 175

Val Ala Pro Val Ile Leu Ala Ala His Arg Asn Asn Tyr Glu Ile Leu

180 185 190

Thr Met Leu Leu Lys Gln Asp Val Ser Leu Pro Lys Pro His Ala Val

195 200 205

Gly Cys Glu Cys Thr Leu Cys Ser Ala Lys Asn Lys Lys Asp Ser Leu

210 215 220

Arg His Ser Arg Phe Arg Leu Asp Ile Tyr Arg Cys Leu Ala Ser Pro

225 230 235 240

Ala Leu Ile Met Leu Thr Glu Glu Asp Pro Ile Leu Arg Ala Phe Glu

245 250 255

Leu Ser Ala Asp Leu Lys Glu Leu Ser Leu Val Glu Val Glu Phe Arg

260 265 270

Asn Asp Tyr Glu Glu Leu Ala Arg Gln Cys Lys Met Phe Ala Lys Asp

275 280 285

Leu Leu Ala Gln Ala Arg Asn Ser Arg Glu Leu Glu Val Ile Leu Asn

290 295 300

His Thr Ser Ser Asp Glu Pro Leu Asp Lys Arg Gly Leu Leu Glu Glu

305 310 315 320

Arg Met Asn Leu Ser Arg Leu Lys Leu Ala Ile Lys Tyr Asn Gln Lys

325 330 335

Glu Phe Val Ser Gln Ser Asn Cys Gln Gln Phe Leu Asn Thr Val Trp

340 345 350

Phe Gly Gln Met Ser Gly Tyr Arg Arg Lys Pro Thr Cys Lys Lys Ile

355 360 365

Met Thr Val Leu Thr Val Gly Ile Phe Trp Pro Val Leu Ser Leu Cys

370 375 380

Tyr Leu Ile Ala Pro Lys Ser Gln Phe Gly Arg Ile Ile His Thr Pro

385 390 395 400

Phe Met Lys Phe Ile Ile His Gly Ala Ser Tyr Phe Thr Phe Leu Leu

405 410 415

Leu Leu Asn Leu Tyr Ser Leu Val Tyr Asn Glu Asp Lys Lys Asn Thr

420 425 430

Met Gly Pro Ala Leu Glu Arg Ile Asp Tyr Leu Leu Ile Leu Trp Ile

435 440 445

Ile Gly Met Ile Trp Ser Asp Ile Lys Arg Leu Trp Tyr Glu Gly Leu

450 455 460

Glu Asp Phe Leu Glu Glu Ser Arg Asn Gln Leu Ser Phe Val Met Asn

465 470 475 480

Ser Leu Tyr Leu Ala Thr Phe Ala Leu Lys Val Val Ala His Asn Lys

485 490 495

Phe His Asp Phe Ala Asp Arg Lys Asp Trp Asp Ala Phe His Pro Thr

500 505 510

Leu Val Ala Glu Gly Leu Phe Ala Phe Ala Asn Val Leu Ser Tyr Leu

515 520 525

Arg Leu Phe Phe Met Tyr Thr Thr Ser Ser Ile Leu Gly Pro Leu Gln

530 535 540

Ile Ser Met Gly Gln Met Leu Gln Asp Phe Gly Lys Phe Leu Gly Met

545 550 555 560

Phe Leu Leu Val Leu Phe Ser Phe Thr Ile Gly Leu Thr Gln Leu Tyr

565 570 575

Asp Lys Gly Tyr Thr Ser Lys Glu Gln Lys Asp Cys Val Gly Ile Phe

580 585 590

Cys Glu Gln Gln Ser Asn Asp Thr Phe His Ser Phe Ile Gly Thr Cys

595 600 605

Phe Ala Leu Phe Trp Tyr Ile Phe Ser Leu Ala His Val Ala Ile Phe

610 615 620

Val Thr Arg Phe Ser Tyr Gly Glu Glu Leu Gln Ser Phe Val Gly Ala

625 630 635 640

Val Ile Val Gly Thr Tyr Asn Val Val Val Val Ile Val Leu Thr Lys

645 650 655

Leu Leu Val Ala Met Leu His Lys Ser Phe Gln Leu Ile Ala Asn His

660 665 670

Glu Asp Lys Glu Trp Lys Phe Ala Arg Ala Lys Leu Trp Leu Ser Tyr

675 680 685

Phe Asp Asp Lys Cys Thr Leu Pro Pro Pro Phe Asn Ile Ile Pro Ser

690 695 700

Pro Lys Thr Ile Cys Tyr Met Ile Ser Ser Leu Ser Lys Trp Ile Cys

705 710 715 720

Ser His Thr Ser Lys Gly Lys Val Lys Arg Gln Asn Ser Leu Lys Glu

725 730 735

Trp Arg Asn Leu Lys Gln Lys Arg Asp Glu Asn Tyr Gln Lys Val Met

740 745 750

Cys Cys Leu Val His Arg Tyr Leu Thr Ser Met Arg Gln Lys Met Gln

755 760 765

Ser Thr Asp Gln Ala Thr Val Glu Asn Leu Asn Glu Leu Arg Gln Asp

770 775 780

Leu Ser Lys Phe Arg Asn Glu Ile Arg Asp Leu Leu Gly Phe Arg Thr

785 790 795 800

Ser Lys Tyr Ala Met Phe Tyr Pro Arg Asn

805 810

<210>78

<211>876

<212>PRT

<213>小家鼠(Mus musculus)

<400>78

Met Ser Arg Gly Asn Glu Asn Arg Leu Thr His Arg Arg Gln Thr Ile

1 5 10 15

Leu Arg Glu Lys Gly Arg Arg Leu Ala Asn Arg Gly Pro Ala Tyr Met

20 25 30

Phe Asn Asp His Ser Thr Ser Leu Ser Ile Glu Glu Glu Arg Phe Leu

35 40 45

Asp Ala Ala Glu Tyr Gly Asn Ile Pro Val Val Arg Lys Met Leu Glu

50 55 60

Glu Cys His Ser Leu Asn Val Asn Cys Val Asp Tyr Met Gly Gln Asp

65 70 75 80

Ala Leu Gln Leu Ala Val Ala Asn Glu His Leu Glu Ile Thr Glu Leu

85 90 95

Leu Leu Lys Lys Glu Asn Leu Ser Arg Val Gly Asp Ala Leu Leu Leu

100 105 110

Ala Ile Ser Lys Gly Tyr Val Arg Ile Val Glu Ala Ile Leu Asn His

115 120 125

Pro Ala Phe Ala Glu Gly Lys Arg Leu Ala Thr Ser Pro Ser Gln Ser

130 135 140

Glu Leu Gln Gln Asp Asp Phe Tyr Ala Tyr Asp Glu Asp Gly Thr Arg

145 150 155 160

Phe Ser His Asp Val Thr Pro Ile Ile Leu Ala Ala His Cys Gln Glu

165 170 175

Tyr Glu Ile Val His Thr Leu Leu Arg Lys Gly Ala Arg Ile Glu Arg

180 185 190

Pro His Asp Tyr Phe Cys Lys Cys Thr Glu Cys Ser Gln Lys Gln Lys

195 200 205

His Asp Ser Phe Ser His Ser Arg Ser Arg Ile Asn Ala Tyr Lys Gly

210 215 220

Leu Ala Ser Pro Ala Tyr Leu Ser Leu Ser Ser Glu Asp Pro Val Met

225 230 235 240

Thr Ala Leu Glu Leu Ser Asn Glu Leu Ala Val Leu Ala Asn Ile Glu

245 250 255

Lys Glu Phe Lys Asn Asp Tyr Arg Lys Leu Ser Met Gln Cys Lys Asp

260 265 270

Phe Val Val Gly Leu Leu Asp Leu Cys Arg Asn Thr Glu Glu Val Glu

275 280 285

Ala Ile Leu Asn Gly Asp Ala Glu Thr Arg Gln Pro Gly Asp Phe Gly

290 295 300

Arg Pro Asn Leu Ser Arg Leu Lys Leu Ala Ile Lys Tyr Glu Val Lys

305 310 315 320

Lys Phe Val Ala His Pro Asn Cys Gln Gln Gln Leu Leu Ser Ile Trp

325 330 335

Tyr Glu Asn Leu Ser Gly Leu Arg Gln Gln Thr Met Ala Val Lys Phe

340 345 350

Leu Val Val Leu Ala Val Ala Ile Gly Leu Pro Phe Leu Ala Leu Ile

355 360 365

Tyr Trp Cys Ala Pro Cys Ser Lys Met Gly Lys Ile Leu Arg Gly Pro

370 375 380

Phe Met Lys Phe Val Ala His Ala Ala Ser Phe Thr Ile Phe Leu Gly

385 390 395 400

Leu Leu Val Met Asn Ala Ala Asp Arg Phe Glu Gly Thr Lys Leu Leu

405 410 415

Pro Asn Glu Thr Ser Thr Asp Asn Ala Arg Gln Leu Phe Arg Met Lys

420 425 430

Thr Ser Cys Phe Ser Trp Met Glu Met Leu Ile Ile Ser Trp Val Ile

435 440 445

Gly Met Ile Trp Ala Glu Cys Lys Glu Ile Trp Thr Gln Gly Pro Lys

450 455 460

Glu Tyr Leu Phe Glu Leu Trp Asn Met Leu Asp Phe Gly Met Leu Ala

465 470 475 480

Ile Phe Ala Ala Ser Phe Ile Ala Arg Phe Met Ala Phe Trp His Ala

485 490 495

Ser Lys Ala Gln Ser Ile Ile Asp Ala Asn Asp Thr Leu Lys Asp Leu

500 505 510

Thr Lys Val Thr Leu Gly Asp Asn Val Lys Tyr Tyr Asn Leu Ala Arg

515 520 525

Ile Lys Trp Asp Pro Thr Asp Pro Gln Ile Ile Ser Glu Gly Leu Tyr

530 535 540

Ala Ile Ala Val Val Leu Ser Phe Ser Arg Ile Ala Tyr Ile Leu Pro

545 550 555 560

Ala Asn Glu Ser Phe Gly Pro Leu Gln Ile Ser Leu Gly Arg Thr Val

565 570 575

Lys Asp Ile Phe Lys Phe Met Val Ile Phe Ile Met Val Phe Val Ala

580 585 590

Phe Met Ile Gly Met Phe Asn Leu Tyr Ser Tyr Tyr Ile Gly Ala Lys

595 600 605

Gln Asn Glu Ala Phe Thr Thr Val Glu Glu Ser Phe Lys Thr Leu Phe

610 615 620

Trp Ala Ile Phe Gly Leu Ser Glu Val Lys Ser Val Val Ile Asn Tyr

625 630 635 640

Asn His Lys Phe Ile Glu Asn Ile Gly Tyr Val Leu Tyr Gly Val Tyr

645 650 655

Asn Val Thr Met Val Ile Val Leu Leu Asn Met Leu Ile Ala Met Ile

660 665 670

Asn Ser Ser Phe Gln Glu Ile Glu Asp Asp Ala Asp Val Glu Trp Lys

675 680 685

Phe Ala Arg Ala Lys Leu Trp Phe Ser Tyr Phe Glu Glu Gly Arg Thr

690 695 700

Leu Pro Val Pro Phe Asn Leu Val Pro Ser Pro Lys Ser Leu Leu Tyr

705 710 715 720

Leu Leu Leu Lys Phe Lys Lys Trp Met Cys Glu Leu Ile Gln Gly Gln

725 730 735

Lys Gln Gly Phe Gln Glu Asp Ala Glu Met Asn Lys Arg Asn Glu Glu

740 745 750

Lys Lys Phe Gly Ile Ser Gly Ser His Glu Asp Leu Ser Lys Phe Ser

755 760 765

Leu Asp Lys Asn Gln Leu Ala His Asn Lys Gln Ser Ser Thr Arg Ser

770 775 780

Ser Glu Asp Tyr His Leu Asn Ser Phe Ser Asn Pro Pro Arg Gln Tyr

785 790 795 800

Gln Lys Ile Met Lys Arg Leu Ile Lys Arg Tyr Val Leu Gln Ala Gln

805 810 815

Ile Asp Lys Glu Ser Asp Glu Val Asn Glu Gly Glu Leu Lys Glu Ile

820 825 830

Lys Gln Asp Ile Ser Ser Leu Arg Tyr Glu Leu Leu Glu Glu Lys Ser

835 840 845

Gln Asn Thr Glu Asp Leu Ala Glu Leu Ile Arg Lys Leu Gly Glu Arg

850 855 860

Leu Ser Leu Glu Pro Lys Leu Glu Glu Ser Arg Arg

865 870 875

<210>79

<211>368

<212>PRT

<213>智人(Homo sapiens)

<400>79

Asp Arg Leu Ser Leu Leu Ser Pro Arg Leu Glu Cys Asn Gly Met Ile

1 5 10 15

Leu Ala His Cys Lys Leu Arg Leu Pro Gly Phe Lys Arg Phe Ser Cys

20 25 30

Leu Ser Leu Pro Ser Ser Trp Asp Tyr Arg His Val Pro Pro Arg Gln

35 40 45

Val His Phe Val Phe Ser Val Glu Thr Gly Phe His Arg Ala Gly Gln

50 55 60

Ala Gly Leu Glu Leu Leu Thr Ser Ser Val Pro Pro Thr Ser Ala Phe

65 70 75 80

Pro Lys Cys Trp Asp Tyr Arg Arg Asp Asp Gln Ala Trp Pro Thr Leu

85 90 95

Ser Ser Phe Arg Gly Leu Asn Lys Phe Ala Phe Leu Pro Lys Phe Phe

100 105 110

Ala His Pro Ile Ser Gln Phe Gln Arg Val Glu Cys Asn Val Gly Cys

115 120 125

Pro Ile Leu Leu Ala Met Lys Tyr Leu Ala Tyr Ser Ser Leu Pro Gly

130 135 140

Ala Asp Thr Met Leu Tyr Phe Tyr Phe Tyr Glu Gln Glu Ala Ser Leu

145 150 155 160

Ala Val Cys Asn Ile Cys Arg Gln Lys Phe His Trp Val Leu Tyr Gln

165 170 175

Ile Ser His Leu Tyr Arg Gly Val Ile Val Asp Asn Phe Leu Leu His

180 185 190

Pro Asp Gly Arg Phe Thr Trp Thr Ile Phe Phe Leu Ser Trp Val Lys

195 200 205

Gln Asn Ser Leu Val Asp Phe Phe Phe Gly Thr Glu Ser Arg Ser Val

210 215 220

Ala Leu Leu Pro Arg Leu Glu Cys Ser Gly Ala Met Ser Thr Leu His

225 230 235 240

Thr Val Leu Arg Pro Ala Tyr Ser His Ile Tyr His Pro Asp Val Lys

245 250 255

Glu Lys Thr His Phe Leu Gly Asn Val Phe Asn Lys Arg Lys Leu Gln

260 265 270

Lys Lys Ile Leu Lys Thr Pro Asn Pro Leu Cys Ala Leu His Ser Ala

275 280 285

Pro Ser Pro Ser Leu Pro Pro Phe Leu Arg Cys Thr Gly Arg Leu Pro

290 295 300

Phe Tyr Leu Gly Leu Asp Asp Phe Leu Phe Val Ala Gly Ala Leu Met

305 310 315 320

Phe Leu Pro Val Ser Phe Leu Asn Pro His Thr Leu Thr Trp Pro Pro

325 330 335

Gln Cys Cys Thr Arg Ser Asp Cys Asn Pro Leu Arg Gly Gln Arg Glu

340 345 350

Ile Ser Ala Leu Ser His Ser Leu Pro Thr Gly Leu Ser Met Pro Leu

355 360 365

<210>80

<211>341

<212>PRT

<213>智人(Homo sapiens)

<400>80

Met Ala Ala Leu Tyr Ala Cys Thr Lys Cys His Gln Arg Phe Pro Phe

1 5 10 15

Glu Ala Leu Ser Gln Gly Gln Gln Leu Cys Lys Glu Cys Arg Ile Ala

20 25 30

His Pro Val Val Lys Cys Thr Tyr Cys Arg Thr Glu Tyr Gln Gln Glu

35 40 45

Arg Leu Glu Cys Asn Gly Thr Ile Ser Ala His Cys Asn Leu His Leu

50 55 60

Pro Gly Ser Ser Asp Ser Pro Ala Ser Ser Ser Arg Val Ala Gly Ile

65 70 75 80

Thr Gly Ile Lys Thr Asn Thr Ile Cys Lys Lys Cys Ala Gln Asn Val

85 90 95

Gln Leu Tyr Gly Thr Pro Lys Pro Cys Gln Tyr Cys Asn Ile Ile Ala

100 105 110

Ala Phe Ile Gly Asn Lys Cys Gln Arg Cys Thr Asn Ser Glu Lys Lys

115 120 125

Tyr Gly Pro Pro Tyr Ser Cys Glu Gln Cys Lys Gln Gln Cys Ala Phe

130 135 140

Asp Arg Lys Asp Asp Arg Lys Lys Val Asp Gly Lys Leu Leu Cys Trp

145 150 155 160

Leu Cys Thr Leu Ser Tyr Lys Arg Val Leu Gln Lys Thr Lys Glu Gln

165 170 175

Arg Lys His Leu Ser Ser Ser Ser Arg Ala Gly His Gln Glu Lys Glu

180 185 190

Gln Tyr Ser Arg Leu Ser Gly Gly Gly His Tyr Asn Ser Gln Lys Thr

195 200 205

Leu Ser Thr Ser Ser Ile Gln Asn Glu Ile Pro Lys Lys Lys Ser Lys

210 215 220

Phe Glu Ser Ile Thr Thr Asn Gly Asp Ser Phe Ser Pro Asp Leu Ala

225 230 235 240

Leu Asp Ser Pro Gly Thr Asp His Phe Val Ile Ile Ala Gln Leu Lys

245 250 255

Glu Glu Val Ala Thr Leu Lys Lys Met Leu His Gln Lys Asp Gln Met

260 265 270

Ile Leu Glu Lys Glu Lys Lys Ile Thr Glu Leu Lys Ala Asp Phe Gln

275 280 285

Tyr Gln Glu Ser Gln Met Arg Ala Lys Met Asn Gln Met Glu Lys Thr

290 295 300

His Lys Glu Val Thr Glu Gln Leu Gln Ala Lys Asn Arg Glu Leu Leu

305 310 315 320

Lys Gln Ala Ala Ala Leu Ser Lys Ser Lys Lys Ser Glu Lys Ser Gly

325 330 335

Ala Ile Thr Ser Pro

340

<210>81

<211>312

<212>PRT

<213>智人(Homo sapiens)

<400>81

Met Ala Ala Leu Tyr Ala Cys Thr Lys Cys His Gln Arg Phe Pro Phe

1 5 10 15

Glu Ala Leu Ser Gln Gly Gln Gln Leu Cys Lys Glu Cys Arg Ile Ala

20 25 30

His Pro Val Val Lys Cys Thr Tyr Cys Arg Thr Glu Tyr Gln Gln Glu

35 40 45

Arg Leu Glu Cys Asn Gly Thr Ile Ser Ala His Cys Asn Leu His Leu

50 55 60

Pro Gly Ser Ser Asp Ser Pro Ala Ser Ser Ser Arg Val Ala Gly Ile

65 70 75 80

Thr Gly Ile Lys Thr Asn Thr Ile Cys Lys Lys Cys Ala Gln Asn Val

85 90 95

Gln Leu Tyr Gly Thr Pro Lys Pro Cys Gln Tyr Cys Asn Ile Ile Ala

100 105 110

Ala Phe Ile Gly Asn Lys Cys Gln Arg Cys Thr Asn Ser Glu Lys Lys

115 120 125

Tyr Gly Pro Pro Tyr Ser Cys Glu Gln Cys Lys Gln Gln Cys Ala Phe

130 135 140

Asp Arg Lys Asp Asp Arg Lys Lys Val Asp Gly Lys Leu Leu Cys Trp

145 150 155 160

Leu Cys Thr Leu Ser Tyr Lys Arg Val Leu Gln Lys Thr Lys Glu Gln

165 170 175

Arg Lys His Leu Ser Ser Ser Ser Arg Ala Gly His Gln Glu Lys Glu

180 185 190

Gln Tyr Ser Arg Leu Ser Gly Gly Gly His Tyr Asn Ser Phe Ser Pro

195 200 205

Asp Leu Ala Leu Asp Ser Pro Gly Thr Asp His Phe Val Ile Ile Ala

210 215 220

Gln Leu Lys Glu Glu Val Ala Thr Leu Lys Lys Met Leu His Gln Lys

225 230 235 240

Asp Gln Met Ile Leu Glu Lys Glu Lys Lys Ile Thr Glu Leu Lys Ala

245 250 255

Asp Phe Gln Tyr Gln Glu Ser Gln Met Arg Ala Lys Met Asn Gln Met

260 265 270

Glu Lys Thr His Lys Glu Val Thr Glu Gln Leu Gln Ala Lys Asn Arg

275 280 285

Glu Leu Leu Lys Gln Ala Ala Ala Leu Ser Lys Ser Lys Lys Ser Glu

290 295 300

Lys Ser Gly Ala Ile Thr Ser Pro

305 310

<210>82

<211>100

<212>PRT

<213>智人(Homo sapiens)

<400>82

Phe Phe Phe Phe Phe Phe Glu Thr Glu Ser Cys Ser Val Ala Glu Ala

1 5 10 15

Gly Val Gln Trp Cys Asp Leu Gly Ser Leu Lys Ser Pro Pro Pro Gly

20 25 30

Ser Ser Asp Ser Pro Ala Ser Ala Ser Arg Val Ala Gly Ile Thr Gly

35 40 45

Met His His His Thr Gln Leu Ile Phe Val Phe Leu Val Glu Thr Gly

50 55 60

Ser His Met Gln Leu Ser Asp Ser Thr Leu Val Ile Thr Thr Ala Gln

65 70 75 80

Asn Ala Lys Ile Thr Ala Arg Ala Pro Arg Asp Leu Phe Phe Phe Phe

85 90 95

Phe Phe Phe Phe

100

<210>83

<211>56

<212>PRT

<213>智人(Homo sapiens)

<400>83

Leu Pro Leu Leu Pro Arg Met Glu Cys Arg Gly Met Ile Ser Ala His

1 5 10 15

Cys Asn Leu Cys Arg Ser Gly Ser Ser Asp Ser Pro Ala Ser Ala Ser

20 25 30

Arg Val Ala Gly Ile Thr Gly Thr Cys His His Ala Gln Leu Ser Phe

35 40 45

Pro Phe Phe Leu Phe Met Arg Trp

50 55

<210>84

<211>46

<212>PRT

<213>智人(Homo sapiens)

<400>84

Leu Pro Leu Leu Pro Arg Met Glu Cys Arg Gly Met Ile Ser Ala His

1 5 10 15

Cys Asn Leu Cys Arg Ser Gly Ser Ser Asp Ser Pro Ala Ser Ala Ser

20 25 30

Arg Val Ala Gly Ile Thr Gly Thr Cys His His Ala Gln Leu

35 40 45

<210>85

<211>699

<212>PRT

<213>智人(Homo sapiens)

<220>

<221>MOD_RES

<222>(677)

<223>可变氨基酸

<400>85

Met Asp Ile Glu Asp Glu Glu Asn Met Ser Ser Ser Ser Thr Asp Val

1 5 10 15

Lys Glu Asn Arg Asn Leu Asp Asn Val Ser Pro Lys Asp Gly Ser Thr

20 25 30

Pro Gly Pro Gly Glu Gly Ser Gln Leu Ser Asn Gly Gly Gly Gly Gly

35 40 45

Pro Gly Arg Lys Arg Pro Leu Glu Glu Gly Ser Asn Gly His Ser Lys

50 55 60

Tyr Arg Leu Lys Lys Arg Arg Lys Thr Pro Gly Pro Val Leu Pro Lys

65 70 75 80

Asn Ala Leu Met Gln Leu Asn Glu Ile Lys Pro Gly Leu Gln Tyr Thr

85 90 95

Leu Leu Ser Gln Thr Gly Pro Val His Ala Pro Leu Phe Val Met Ser

100 105 110

Val Glu Val Asn Gly Gln Val Phe Glu Gly Ser Gly Pro Thr Lys Lys

115 120 125

Lys Ala Lys Leu His Ala Ala Glu Lys Ala Leu Arg Ser Phe Val Gln

130 135 140

Phe Pro Asn Ala Ser Glu Ala His Leu Ala Met Gly Arg Thr Leu Ser

145 150 155 160

Val Asn Thr Asp Phe Thr Ser Asp Gln Ala Asp Phe Pro Asp Thr Leu

165 170 175

Phe Asn Gly Phe Glu Thr Pro Asp Lys Ala Glu Pro Pro Phe Tyr Val

180 185 190

Gly Ser Asn Gly Asp Asp Ser Phe Ser Ser Ser Gly Asp Leu Ser Leu

195 200 205

Ser Ala Ser Pro Val Pro Ala Ser Leu Ala Gln Pro Pro Leu Pro Val

210 215 220

Leu Pro Pro Phe Pro Pro Pro Ser Gly Lys Asn Pro Val Met Ile Leu

225 230 235 240

Asn Glu Leu Arg Pro Gly Leu Lys Tyr Asp Phe Leu Ser Glu Ser Gly

245 250 255

Glu Ser His Ala Lys Ser Phe Val Met Ser Val Val Val Asp Gly Gln

260 265 270

Phe Phe Glu Gly Ser Gly Arg Asn Lys Lys Leu Ala Lys Ala Arg Ala

275 280 285

Ala Gln Ser Ala Leu Ala Ala Ile Phe Asn Leu His Leu Asp Gln Thr

290 295 300

Pro Ser Arg Gln Pro Ile Pro Ser Glu Gly Leu Gln Leu His Leu Pro

305 310 315 320

Gln Val Leu Ala Asp Ala Val Ser Arg Leu Val Leu Gly Lys Phe Gly

325 330 335

Asp Leu Thr Asp Asn Phe Ser Ser Pro His Ala Arg Arg Lys Val Leu

340 345 350

Ala Gly Val Val Met Thr Thr Gly Thr Asp Val Lys Asp Ala Lys Val

355 360 365

Ile Ser Val Ser Thr Gly Thr Lys Cys Ile Asn Gly Glu Tyr Met Ser

370 375 380

Asp Arg Gly Leu Ala Leu Asn Asp Cys His Ala Glu Ile Ile Ser Arg

385 390 395 400

Arg Ser Leu Leu Arg Phe Leu Tyr Thr Gln Leu Glu Leu Tyr Leu Asn

405 410 415

Asn Lys Asp Asp Gln Lys Arg Ser Ile Phe Gln Lys Ser Glu Arg Gly

420 425 430

Gly Phe Arg Leu Lys Glu Asn Val Gln Phe His Leu Tyr Ile Ser Thr

435 440 445

Ser Pro Cys Gly Asp Ala Arg Ile Phe Ser Pro His Glu Pro Ile Leu

450 455 460

Glu Gly Ser Arg Ser Tyr Thr Gln Ala Gly Val Gln Trp Cys Asn His

465 470 475 480

Gly Ser Leu Gln Pro Arg Pro Pro Gly Leu Leu Ser Asp Pro Ser Thr

485 490 495

Ser Thr Phe Gln Gly Ala Gly Thr Thr Glu Pro Ala Asp Arg His Pro

500 505 510

Asn Arg Lys Ala Arg Gly Gln Leu Arg Thr Lys Ile Glu Ser Gly Glu

515 520 525

Gly Thr Ile Pro Val Arg Ser Asn Ala Ser Ile Gln Thr Trp Asp Gly

530 535 540

Val Leu Gln Gly Glu Arg Leu Leu Thr Met Ser Cys Ser Asp Lys Ile

545 550 555 560

Ala Arg Trp Asn Val Val Gly Ile Gln Gly Ser Leu Leu Ser Ile Phe

565 570 575

Val Glu Pro Ile Tyr Phe Ser Ser Ile Ile Leu Gly Ser Leu Tyr His

580 585 590

Gly Asp His Leu Ser Arg Ala Met Tyr Gln Arg Ile Ser Asn Ile Glu

595 600 605

Asp Leu Pro Pro Leu Tyr Thr Leu Asn Lys Pro Leu Leu Ser Gly Ile

610 615 620

Ser Asn Ala Glu Ala Arg Gln Pro Gly Lys Ala Pro Asn Phe Ser Val

625 630 635 640

Asn Trp Thr Val Gly Asp Ser Ala Ile Glu Val Ile Asn Ala Thr Thr

645 650 655

Gly Lys Asp Glu Leu Gly Arg Ala Ser Arg Leu Cys Lys His Ala Leu

660 665 670

Tyr Cys Arg Trp Xaa Ala Cys Ala Arg Gln Gly Ser Leu Pro Leu Thr

675 680 685

Thr Leu Gln Asp Tyr Gln Ala Gln Arg Val Pro

690 695

<210>86

<21l>331

<212>PRT

<213>智人(Homo sapiens)

<400>86

Met Leu Leu Ser Gln Asn Ala Phe Ile Val Arg Ser Leu Asn Leu Val

1 5 10 15

Leu Met Val Tyr Ile Ser Leu Val Phe Gly Ile Ser Tyr Asp Ser Pro

20 25 30

Asp Tyr Thr Asp Glu Ser Cys Thr Phe Lys Ile Ser Leu Arg Asn Phe

35 40 45

Arg Ser Ile Leu Ser Trp Glu Leu Lys Asn His Ser Ile Val Pro Thr

50 55 60

His Tyr Thr Leu Leu Tyr Thr Ile Met Ser Lys Pro Glu Asp Leu Lys

65 70 75 80

Val Val Lys Asn Cys Ala Asn Thr Thr Arg Ser Phe Cys Asp Leu Thr

85 90 95

Asp Glu Trp Arg Ser Thr His Glu Ala Tyr Val Thr Val Leu Glu Gly

100 105 110

Phe Ser Gly Asn Thr Thr Leu Phe Ser Cys Ser His Asn Phe Trp Leu

115 120 125

Ala Ile Asp Met Ser Phe Glu Pro Pro Glu Phe Glu Ile Val Gly Phe

130 135 140

Thr Asn His Ile Asn Val Met Val Lys Phe Pro Ser Ile Val Glu Glu

145 150 155 160

Glu Leu Gln Phe Asp Leu Ser Leu Val Ile Glu Glu Gln Ser Glu Gly

165 170 175

Ile Val Lys Lys His Lys Pro Glu Ile Lys Gly Asn Met Ser Gly Asn

180 185 190

Phe Thr Tyr Ile Ile Asp Lys Leu Ile Pro Asn Thr Asn Tyr Cys Val

195 200 205

Ser Val Tyr Leu Glu His Ser Asp Glu Gln Ala Val Ile Lys Ser Pro

210 215 220

Leu Lys Cys Thr Leu Leu Pro Pro Gly Gln Glu Ser Glu Ser Ala Glu

225 230 235 240

Ser Ala Lys Ile Gly Gly Ile Ile Thr Val Phe Leu Ile Ala Leu Val

245 250 255

Leu Thr Ser Thr Ile Val Thr Leu Lys Trp Ile Gly Tyr Ile Cys Leu

260 265 270

Arg Asn Ser Leu Pro Lys Val Leu Arg Gln Gly Leu Thr Lys Gly Trp

275 280 285

Asn Ala Val Ala Ile His Arg Cys Ser His Asn Ala Leu Gln Ser Glu

290 295 300

Thr Pro Glu Leu Lys Gln Ser Ser Cys Leu Ser Phe Pro Ser Ser Trp

305 310 315 320

Asp Tyr Lys Arg Ala Ser Leu Cys Pro Ser Asp

325 330

<210>87

<211>841

<212>PRT

<213>智人(Homo sapiens)

<400>87

Met Pro Leu Ala Ala Tyr Cys Tyr Leu Arg Val Val Gly Lys Gly Ser

1 5 10 15

Tyr Gly Glu Val Thr Leu Val Lys His Arg Arg Asp Gly Lys Gln Tyr

20 25 30

Val Ile Lys Lys Leu Asn Leu Arg Asn Ala Ser Ser Arg Glu Arg Arg

35 40 45

Ala Ala Glu Gln Glu Ala Gln Leu Leu Ser Gln Leu Lys His Pro Asn

50 55 60

Ile Val Thr Tyr Lys Glu Ser Trp Glu Gly Gly Asp Gly Leu Leu Tyr

65 70 75 80

Ile Val Met Gly Phe Cys Glu Gly Gly Asp Leu Tyr Arg Lys Leu Lys

85 90 95

Glu Gln Lys Gly Gln Leu Leu Pro Glu Asn Gln Val Val Glu Trp Phe

100 105 110

Val Gln Ile Ala Met Ala Leu Gln Tyr Leu His Glu Lys His Ile Leu

115 120 125

His Arg Asp Leu Lys Thr Gln Asn Val Phe Leu Thr Arg Thr Asn Ile

130 135 140

Ile Lys Val Gly Asp Leu Gly Ile Ala Arg Val Leu Glu Asn His Cys

145 150 155 160

Asp Met Ala Ser Thr Leu Ile Gly Thr Pro Tyr Tyr Met Ser Pro Glu

165 170 175

Leu Phe Ser Asn Lys Pro Tyr Asn Tyr Lys Ser Asp Val Trp Ala Leu

180 185 190

Gly Cys Cys Val Tyr Glu Met Ala Thr Leu Lys His Ala Phe Asn Ala

195 200 205

Lys Asp Met Asn Ser Leu Val Tyr Arg Ile Ile Glu Gly Lys Leu Pro

210 215 220

Ala Met Pro Arg Asp Tyr Ser Pro Glu Leu Ala Glu Leu Ile Arg Thr

225 230 235 240

Met Leu Ser Lys Arg Pro Glu Glu Arg Pro Ser Val Arg Ser Ile Leu

245 250 255

Arg Gln Pro Tyr Ile Lys Arg Gln Ile Ser Phe Phe Leu Glu Ala Thr

260 265 270

Lys Ile Lys Thr Ser Lys Asn Asn Ile Lys Asn Gly Asp Ser Gln Ser

275 280 285

Lys Pro Phe Ala Thr Val Val Ser Gly Glu Ala Glu Ser Asn His Glu

290 295 300

Val Ile His Pro Gln Pro Leu Ser Ser Glu Gly Ser Gln Thr Tyr Ile

305 310 315 320

Met Gly Glu Gly Lys Cys Leu Ser Gln Glu Lys Pro Arg Ala Ser Gly

325 330 335

Leu Leu Lys Ser Pro Ala Ser Leu Lys Ala His Thr Cys Lys Gln Asp

340 345 350

Leu Ser Asn Thr Thr Glu Leu Ala Thr Ile Ser Ser Val Asn Ile Asp

355 360 365

Ile Leu Pro Ala Lys Gly Arg Asp Ser Val Ser Asp Gly Phe Val Gln

370 375 380

Glu Asn Gln Pro Arg Tyr Leu Asp Ala Ser Asn Glu Leu Gly Gly Ile

385 390 395 400

Cys Ser Ile Ser Gln Val Glu Glu Glu Met Leu Gln Asp Asn Thr Lys

405 410 415

Ser Ser Ala Gln Pro Glu Asn Leu Ile Pro Met Trp Ser Ser Asp Ile

420 425 430

Val Thr Gly Glu Lys Asn Glu Pro Val Lys Pro Leu Gln Pro Leu Ile

435 440 445

Lys Glu Gln Lys Pro Lys Asp Gln Ser Leu Ala Leu Ser Pro Lys Leu

450 455 460

Glu Cys Ser Gly Thr Ile Leu Ala His Ser Asn Leu Arg Leu Leu Gly

465 470 475 480

Ser Ser Asp Ser Pro Ala Ser Ala Ser Arg Val Ala Gly Ile Thr Gly

485 490 495

Val Cys His His Ala Gln Asp Gln Val Ala Gly Glu Cys Ile Ile Glu

500 505 510

Lys Gln Gly Arg Ile His Pro Asp Leu Gln Pro His Asn Ser Gly Ser

515 520 525

Glu Pro Ser Leu Ser Arg Gln Arg Arg Gln Lys Arg Arg Glu Gln Thr

530 535 540

Glu His Arg Gly Glu Lys Arg Gln Val Arg Arg Asp Leu Phe Ala Phe

545 550 555 560

Gln Glu Ser Pro Pro Arg Phe Leu Pro Ser His Pro Ile Val Gly Lys

565 570 575

Val Asp Val Thr Ser Thr Gln Lys Glu Ala Glu Asn Gln Arg Arg Val

580 585 590

Val Thr Gly Ser Val Ser Ser Ser Arg Ser Ser Glu Met Ser Ser Ser

595 600 605

Lys Asp Arg Pro Leu Ser Ala Arg Glu Arg Arg Arg Leu Lys Gln Ser

610 615 620

Gln Glu Glu Met Ser Ser Ser Gly Pro Ser Val Arg Lys Ala Ser Leu

625 630 635 640

Ser Val Ala Gly Pro Gly Lys Pro Gln Glu Glu Asp Gln Pro Leu Pro

645 650 655

Ala Arg Arg Leu Ser Ser Asp Cys Ser Val Thr Gln Glu Arg Lys Gln

660 665 670

Ile His Cys Leu Ser Glu Asp Glu Leu Ser Ser Ser Thr Ser Ser Thr

675 680 685

Asp Lys Ser Asp Gly Asp Tyr Gly Glu Gly Lys Gly Gln Thr Asn Glu

690 695 700

Ile Asn Ala Leu Val Gln Leu Met Thr Gln Thr Leu Lys Leu Asp Ser

705 710 715 720

Lys Glu Ser Cys Glu Asp Val Pro Val Ala Asn Pro Val Ser Glu Phe

725 730 735

Lys Leu His Arg Lys Tyr Arg Asp Thr Leu Ile Leu His Gly Lys Val

740 745 750

Ala Glu Glu Ala Glu Glu Ile His Phe Lys Glu Leu Pro Ser Ala Ile

755 760 765

Met Pro Gly Ser Glu Lys Ile Arg Arg Leu Val Glu Val Leu Arg Thr

770 775 780

Asp Val Ile Arg Gly Leu Gly Val Gln Leu Leu Glu Gln Val Tyr Asp

785 790 795 800

Leu Leu Glu Glu Glu Asp Glu Phe Asp Arg Glu Val Arg Leu Arg Glu

805 810 815

His Met Gly Glu Lys Tyr Thr Thr Tyr Ser Val Lys Ala Arg Gln Leu

820 825 830

Lys Phe Phe Glu Glu Asn Met Asn Phe

835 840

<210>88

<211>759

<212>PRT

<213>智人(Homo sapiens)

<400>88

Met Met Ala Ala Leu Tyr Pro Ser Thr Asp Leu Ser Gly Ala Ser Ser

1 5 10 15

Ser Ser Leu Pro Ser Ser Pro Ser Ser Ser Ser Pro Asn Glu Val Met

20 25 30

Ala Leu Lys Asp Val Arg Glu Val Lys Glu Glu Asn Thr Leu Asn Glu

35 40 45

Lys Leu Phe Leu Leu Ala Cys Asp Lys Gly Asp Tyr Tyr Met Val Lys

50 55 60

Lys Ile Leu Glu Glu Asn Ser Ser Gly Asp Leu Asn Ile Asn Cys Val

65 70 75 80

Asp Val Leu Gly Arg Asn Ala Val Thr Ile Thr Ile Glu Asn Glu Asn

85 90 95

Leu Asp Ile Leu Gln Leu Leu Leu Asp Tyr Gly Cys Gln Lys Leu Met

100 105 110

Glu Arg Ile Gln Asn Pro Glu Tyr Ser Thr Thr Met Asp Val Ala Pro

115 120 125

Val Ile Leu Ala Ala His Arg Asn Asn Tyr Glu Ile Leu Thr Met Leu

130 135 140

Leu Lys Gln Asp Val Ser Leu Pro Lys Pro His Ala Val Gly Cys Glu

145 150 155 160

Cys Thr Leu Cys Ser Ala Lys Asn Lys Lys Asp Ser Leu Arg His Ser

165 170 175

Arg Phe Arg Leu Asp Ile Tyr Arg Cys Leu Ala Ser Pro Ala Leu Ile

180 185 190

Met Leu Thr Glu Glu Asp Pro Ile Leu Arg Ala Phe Glu Leu Ser Ala

195 200 205

Asp Leu Lys Glu Leu Ser Leu Val Glu Val Glu Phe Arg Asn Asp Tyr

210 215 220

Glu Glu Leu Ala Arg Gln Cys Lys Met Phe Ala Lys Asp Leu Leu Ala

225 230 235 240

Gln Ala Arg Asn Ser Arg Glu Leu Glu Val Ile Leu Asn His Thr Ser

245 250 255

Ser Asp Glu Pro Leu Asp Lys Arg Gly Leu Leu Glu Glu Arg Met Asn

260 265 270

Leu Ser Arg Leu Lys Leu Ala Ile Lys Tyr Asn Gln Lys Glu Phe Val

275 280 285

Ser Gln Ser Asn Cys Gln Gln Phe Leu Asn Thr Val Trp Phe Gly Gln

290 295 300

Met Ser Gly Tyr Arg Arg Lys Pro Thr Cys Lys Lys Ile Met Thr Val

305 310 315 320

Leu Thr Val Gly Ile Phe Trp Pro Val Leu Ser Leu Cys Tyr Leu Ile

325 330 335

Ala Pro Lys Ser Gln Phe Gly Arg Ile Ile His Thr Pro Phe Met Lys

340 345 350

Phe Ile Ile His Gly Ala Ser Tyr Phe Thr Phe Leu Leu Leu Leu Asn

355 360 365

Leu Tyr Ser Leu Val Tyr Asn Glu Asp Lys Lys Asn Thr Met Gly Pro

370 375 380

Ala Leu Glu Arg Ile Asp Tyr Leu Leu Ile Leu Trp Ile Ile Gly Met

385 390 395 400

Ile Trp Ser Asp Ile Lys Arg Leu Trp Tyr Glu Gly Leu Glu Asp Phe

405 410 415

Leu Glu Glu Ser Arg Asn Gln Leu Ser Phe Val Met Asn Ser Leu Tyr

420 425 430

Leu Ala Thr Phe Ala Leu Lys Val Val Ala His Asn Lys Phe His Asp

435 440 445

Phe Ala Asp Arg Lys Asp Trp Asp Ala Phe His Pro Thr Leu Val Ala

450 455 460

Glu Gly Leu Phe Ala Phe Ala Asn Val Leu Ser Tyr Leu Arg Leu Phe

465 470 475 480

Phe Met Tyr Thr Thr Ser Ser Ile Leu Gly Pro Leu Gln Ile Ser Met

485 490 495

Gly Gln Met Leu Gln Asp Phe Gly Lys Phe Leu Gly Met Phe Leu Leu

500 505 510

Val Leu Phe Ser Phe Thr Ile Gly Leu Thr Gln Leu Tyr Asp Lys Gly

515 520 525

Tyr Thr Ser Lys Glu Gln Lys Asp Cys Val Gly Ile Phe Cys Glu Gln

530 535 540

Gln Ser Asn Asp Thr Phe His Ser Phe Ile Gly Thr Cys Phe Ala Leu

545 550 555 560

Phe Trp Tyr Ile Phe Ser Leu Ala His Val Ala Ile Phe Val Thr Arg

565 570 575

Phe Ser Tyr Gly Glu Glu Leu Gln Ser Phe Val Gly Ala Val Ile Val

580 585 590

Gly Thr Tyr Asn Val Val Val Val Ile Val Leu Thr Lys Leu Leu Val

595 600 605

Ala Met Leu His Lys Ser Phe Gln Leu Ile Ala Asn His Glu Asp Lys

610 615 620

Glu Trp Lys Phe Ala Arg Ala Lys Leu Trp Leu Ser Tyr Phe Asp Asp

625 630 635 640

Lys Cys Thr Leu Pro Pro Pro Phe Asn Ile Ile Pro Ser Pro Lys Thr

645 650 655

Ile Cys Tyr Met Ile Ser Ser Leu Ser Lys Trp Ile Cys Ser His Thr

660 665 670

Ser Lys Gly Lys Val Lys Arg Gln Asn Ser Leu Lys Glu Trp Arg Asn

675 680 685

Leu Lys Gln Lys Arg Asp Glu Asn Tyr Gln Lys Val Met Cys Cys Leu

690 695 700

Val His Arg Tyr Leu Thr Ser Met Arg Gln Lys Met Gln Ser Thr Asp

705 710 715 720

Gln Ala Thr Val Glu Asn Leu Asn Glu Leu Arg Gln Asp Leu Ser Lys

725 730 735

Phe Arg Asn Glu Ile Arg Asp Leu Leu Gly Phe Arg Thr Ser Lys Tyr

740 745 750

Ala Met Phe Tyr Pro Arg Asn

755

<210>89

<211>848

<212>PRT

<213>智人(Homo sapiens)

<400>89

Met Glu Gly Ser Pro Ser Leu Arg Arg Met Thr Val Met Arg Glu Lys

1 5 10 15

Gly Arg Arg Gln Ala Val Arg Gly Pro Ala Phe Met Phe Asn Asp Arg

20 25 30

Gly Thr Ser Leu Thr Ala Glu Glu Glu Arg Phe Leu Asp Ala Ala Glu

35 40 45

Tyr Gly Asn Ile Pro Val Val Arg Lys Met Leu Glu Glu Ser Lys Thr

50 55 60

Leu Asn Val Asn Cys Val Asp Tyr Met Gly Gln Asn Ala Leu Gln Leu

65 70 75 80

Ala Val Gly Asn Glu His Leu Glu Val Thr Glu Leu Leu Leu Lys Lys

85 90 95

Glu Asn Leu Ala Arg Ile Gly Asp Ala Leu Leu Leu Ala Ile Ser Lys

100 105 110

Gly Tyr Val Arg Ile Val Glu Ala Ile Leu Asn His Pro Gly Phe Ala

115 120 125

Ala Ser Lys Arg Leu Thr Leu Ser Pro Cys Glu Gln Glu Leu Gln Asp

130 135 140

Asp Asp Phe Tyr Ala Tyr Asp Glu Asp Gly Thr Arg Phe Ser Pro Asp

145 150 155 160

Ile Thr Pro Ile Ile Leu Ala Ala His Cys Gln Lys Tyr Glu Val Val

165 170 175

His Met Leu Leu Met Lys Gly Ala Arg Ile Glu Arg Pro His Asp Tyr

180 185 190

Phe Cys Lys Cys Gly Asp Cys Met Glu Lys Gln Arg His Asp Ser Phe

195 200 205

Ser His Ser Arg Ser Arg Ile Asn Ala Tyr Lys Gly Leu Ala Ser Pro

210 215 220

Ala Tyr Leu Ser Leu Ser Ser Glu Asp Pro Val Leu Thr Ala Leu Glu

225 230 235 240

Leu Ser Asn Glu Leu Ala Lys Leu Ala Asn Ile Glu Lys Glu Phe Lys

245 250 255

Asn Asp Tyr Arg Lys Leu Ser Met Gln Cys Lys Asp Phe Val Val Gly

260 265 270

Val Leu Asp Leu Cys Arg Asp Ser Glu Glu Val Glu Ala Ile Leu Asn

275 280 285

Gly Asp Leu Glu Ser Ala Glu Pro Leu Glu Val His Arg His Lys Ala

290 295 300

Ser Leu Ser Arg Val Lys Leu Ala Ile Lys Tyr Glu Val Lys Lys Phe

305 310 315 320

Val Ala His Pro Asn Cys Gln Gln Gln Leu Leu Thr Ile Trp Tyr Glu

325 330 335

Asn Leu Ser Gly Leu Arg Glu Gln Thr Ile Ala Ile Lys Cys Leu Val

340 345 350

Val Leu Val Val Ala Leu Gly Leu Pro Phe Leu Ala Ile Gly Tyr Trp

355 360 365

Ile Ala Pro Cys Ser Arg Leu Gly Lys Ile Leu Arg Ser Pro Phe Met

370 375 380

Lys Phe Val Ala His Ala Ala Ser Phe Ile Ile Phe Leu Gly Leu Leu

385 390 395 400

Val Phe Asn Ala Ser Asp Arg Phe Glu Gly Ile Thr Thr Leu Pro Asn

405 410 415

Ile Thr Val Thr Asp Tyr Pro Lys Gln Ile Phe Arg Val Lys Thr Thr

420 425 430

Gln Phe Thr Trp Thr Glu Met Leu Ile Met Val Trp Val Leu Gly Met

435 440 445

Met Trp Ser Glu Cys Lys Glu Leu Trp Leu Glu Gly Pro Arg Glu Tyr

450 455 460

Ile Leu Gln Leu Trp Asn Val Leu Asp Phe Gly Met Leu Ser Ile Phe

465 470 475 480

Ile Ala Ala Phe Thr Ala Arg Phe Leu Ala Phe Leu Gln Ala Thr Lys

485 490 495

Ala Gln Gln Tyr Val Asp Ser Tyr Val Gln Glu Ser Asp Leu Ser Glu

500 505 510

Val Thr Leu Pro Pro Glu Ile Gln Tyr Phe Thr Tyr Ala Arg Asp Lys

515 520 525

Trp Leu Pro Ser Asp Pro Gln Ile Ile Ser Glu Gly Leu Tyr Ala Ile

530 535 540

Ala Val Val Leu Ser Phe Ser Arg Ile Ala Tyr Ile Leu Pro Ala Asn

545 550 555 560

Glu Ser Phe Gly Pro Leu Gln Ile Ser Leu Gly Arg Thr Val Lys Asp

565 570 575

Ile Phe Lys Phe Met Val Leu Phe Ile Met Val Phe Phe Ala Phe Met

580 585 590

Ile Gly Met Phe Ile Leu Tyr Ser Tyr Tyr Leu Gly Ala Lys Val Asn

595 600 605

Ala Ala Phe Thr Thr Val Glu Glu Ser Phe Lys Thr Leu Phe Trp Ser

610 615 620

Ile Phe Gly Leu Ser Glu Val Thr Ser Val Val Leu Lys Tyr Asp His

625 630 635 640

Lys Phe Ile Glu Asn Ile Gly Tyr Val Leu Tyr Gly Ile Tyr Asn Val

645 650 655

Thr Met Val Val Val Leu Leu Asn Met Leu Ile Ala Met Ile Asn Ser

660 665 670

Ser Tyr Gln Glu Ile Glu Asp Asp Ser Asp Val Glu Trp Lys Phe Ala

675 680 685

Arg Ser Lys Leu Trp Leu Ser Tyr Phe Asp Asp Gly Lys Thr Leu Pro

690 695 700

Pro Pro Phe Ser Leu Val Pro Ser Pro Lys Ser Phe Val Tyr Phe Ile

705 710 715 720

Met Arg Ile Val Asn Phe Pro Lys Cys Arg Arg Arg Arg Leu Gln Lys

725 730 735

Asp Ile Glu Met Gly Met Gly Asn Ser Lys Ser Arg Leu Asn Leu Phe

740 745 750

Thr Gln Ser Asn Ser Arg Val Phe Glu Ser His Ser Phe Asn Ser Ile

755 760 765

Leu Asn Gln Pro Thr Arg Tyr Gln Gln Ile Met Lys Arg Leu Ile Lys

770 775 780

Arg Tyr Val Leu Lys Ala Gln Val Asp Lys Glu Asn Asp Glu Val Asn

785 790 795 800

Glu Gly Glu Leu Lys Glu Ile Lys Gln Asp Ile Ser Ser Leu Arg Tyr

805 810 815

Glu Leu Leu Glu Asp Lys Ser Gln Ala Thr Glu Glu Leu Ala Ile Leu

820 825 830

Ile His Lys Leu Ser Glu Lys Leu Asn Pro Ser Met Leu Arg Cys Glu

835 840 845

<210>90

<211>215

<212>PRT

<213>智人(Homo sapiens)

<400>90

Met Ser Glu Thr Val Pro Pro Ala Pro Ala Ala Ser Ala Ala Pro Glu

1 5 10 15

Lys Pro Leu Ala Gly Lys Lys Ala Lys Lys Pro Ala Lys Ala Ala Ala

20 25 30

Ala Ser Lys Lys Lys Pro Ala Gly Pro Ser Val Ser Glu Leu Ile Val

35 40 45

Gln Ala Ala Ser Ser Ser Lys Glu Arg Gly Gly Val Ser Leu Ala Ala

50 55 60

Leu Lys Lys Ala Leu Ala Ala Ala Gly Tyr Asp Val Glu Lys Asn Asn

65 70 75 80

Ser Arg Ile Lys Leu Gly Ile Lys Ser Leu Val Ser Lys Gly Thr Leu

85 90 95

Val Gln Thr Lys Gly Thr Gly Ala Ser Gly Ser Phe Lys Leu Asn Lys

100 105 110

Lys Ala Ser Ser Val Glu Thr Lys Pro Gly Ala Ser Lys Val Ala Thr

115 120 125

Lys Thr Lys Ala Thr Gly Ala Ser Lys Lys Leu Lys Lys Ala Thr Gly

130 135 140

Ala Ser Lys Lys Ser Val Lys Thr Pro Lys Lys Ala Lys Lys Pro Ala

145 150 155 160

Ala Thr Arg Lys Ser Ser Lys Asn Pro Lys Lys Pro Lys Thr Val Lys

165 170 175

Pro Lys Lys Val Ala Lys Ser Pro Ala Lys Ala Lys Ala Val Lys Pro

180 185 190

Lys Ala Ala Lys Ala Arg Val Thr Lys Pro Lys Thr Ala Lys Pro Lys

195 200 205

Lys Ala Ala Pro Lys Lys Lys

210 215

<210>91

<211>931

<212>PRT

<213>智人(Homo sapiens)

<400>91

Met Ser Gln Ser Pro Ala Phe Gly Pro Arg Arg Gly Ser Ser Pro Arg

1 5 10 15

Gly Ala Ala Gly Ala Ala Ala Arg Arg Asn Glu Ser Gln Asp Tyr Leu

20 25 30

Leu Met Asp Ser Glu Leu Gly Glu Asp Gly Cys Pro Gln Ala Pro Leu

35 40 45

Pro Cys Tyr Gly Tyr Tyr Pro Cys Phe Arg Gly Ser Asp Asn Arg Leu

50 55 60

Ala His Arg Arg Gln Thr Val Leu Arg Glu Lys Gly Arg Arg Leu Ala

65 70 75 80

Asn Arg Gly Pro Ala Tyr Met Phe Ser Asp Arg Ser Thr Ser Leu Ser

85 90 95

Ile Glu Glu Glu Arg Phe Leu Asp Ala Ala Glu Tyr Gly Asn Ile Pro

100 105 110

Val Val Arg Lys Met Leu Glu Glu Cys His Ser Leu Asn Val Asn Cys

115 120 125

Val Asp Tyr Met Gly Gln Asn Ala Leu Gln Leu Ala Val Ala Asn Glu

130 135 140

His Leu Glu Ile Thr Glu Leu Leu Leu Lys Lys Glu Asn Leu Ser Arg

145 150 155 160

Val Gly Asp Ala Leu Leu Leu Ala Ile Ser Lys Gly Tyr Val Arg Ile

165 170 175

Val Glu Ala Ile Leu Ser His Pro Ala Phe A1a Glu Gly Lys Arg Leu

180 185 190

Ala Thr Ser Pro Ser Gln Ser Glu Leu Gln Gln Asp Asp Phe Tyr Ala

195 200 205

Tyr Asp Glu Asp Gly Thr Arg Phe Ser His Asp Val Thr Pro Ile Ile

210 215 220

Leu Ala Ala His Cys Gln Glu Tyr Glu Ile Val His Thr Leu Leu Arg

225 230 235 240

Lys Gly Ala Arg Ile Glu Arg Pro His Asp Tyr Phe Cys Lys Cys Asn

245 250 255

Asp Cys Asn Gln Lys Gln Lys His Asp Ser Phe Ser His Ser Arg Ser

260 265 270

Arg Ile Asn Ala Tyr Lys Gly Leu Ala Ser Pro Ala Tyr Leu Ser Leu

275 280 285

Ser Ser Glu Asp Pro Val Met Thr Ala Leu Glu Leu Ser Asn Glu Leu

290 295 300

Ala Val Leu Ala Asn Ile Glu Lys Glu Phe Lys Asn Asp Tyr Lys Lys

305 310 315 320

Leu Ser Met Gln Cys Lys Asp Phe Val Val Gly Leu Leu Asp Leu Cys

325 330 335

Arg Asn Thr Glu Glu Val Glu Ala Ile Leu Asn Gly Asp Val Glu Thr

340 345 350

Leu Gln Ser Gly Asp His Gly Arg Pro Asn Leu Ser Arg Leu Lys Leu

355 360 365

Ala Ile Lys Tyr Glu Val Lys Lys Phe Val Ala His Pro Asn Cys Gln

370 375 380

Gln Gln Leu Leu Ser Ile Trp Tyr Glu Asn Leu Ser Gly Leu Arg Gln

385 390 395 400

Gln Thr Met Ala Val Lys Phe Leu Val Val Leu Ala Val Ala Ile Gly

405 410 415

Leu Pro Phe Leu Ala Leu Ile Tyr Trp Phe Ala Pro Cys Ser Lys Met

420 425 430

Gly Lys Ile Met Arg Gly Pro Phe Met Lys Phe Val Ala His Ala Ala

435 440 445

Ser Phe Thr Ile Phe Leu Gly Leu Leu Val Met Asn Ala Ala Asp Arg

450 455 460

Phe Glu Gly Thr Lys Leu Leu Pro Asn Glu Thr Ser Thr Asp Asn Ala

465 470 475 480

Lys Gln Leu Phe Arg Met Lys Thr Ser Cys Phe Ser Trp Met Glu Met

485 490 495

Leu Ile Ile Ser Trp Val Ile Gly Met Ile Trp Ala Glu Cys Lys Glu

500 505 510

Ile Trp Thr Gln Gly Pro Lys Glu Tyr Leu Phe Glu Leu Trp Asn Met

515 520 525

Leu Asp Phe Gly Met Leu Ala Ile Phe Ala Ala Ser Phe Ile Ala Arg

530 535 540

Phe Met Ala Phe Trp His Ala Ser Lys Ala Gln Ser Ile Ile Asp Ala

545 550 555 560

Asn Asp Thr Leu Lys Asp Leu Thr Lys Val Thr Leu Gly Asp Asn Val

565 570 575

Lys Tyr Tyr Asn Leu Ala Arg Ile Lys Trp Asp Pro Ser Asp Pro Gln

580 585 590

Ile Ile Ser Glu Gly Leu Tyr Ala Ile Ala Val Val Leu Ser Phe Ser

595 600 605

Arg Ile Ala Tyr Ile Leu Pro Ala Asn Glu Ser Phe Gly Pro Leu Gln

610 615 620

Ile Ser Leu Gly Arg Thr Val Lys Asp Ile Phe Lys Phe Met Val Ile

625 630 635 640

Phe Ile Met Val Phe Val Ala Phe Met Ile Gly Met Phe Asn Leu Tyr

645 650 655

Ser Tyr Tyr Ile Gly Ala Lys Gln Asn Glu Ala Phe Thr Thr Val Glu

660 665 670

Glu Ser Phe Lys Thr Leu Phe Trp Ala Ile Phe Gly Leu Ser Glu Val

675 680 685

Lys Ser Val Val IIe Asn Tyr Asn His Lys Phe Ile Glu Asn Ile Gly

690 695 700

Tyr Val Leu Tyr Gly Val Tyr Asn Val Thr Met Val Ile Val Leu Leu

705 710 715 720

Asn Met Leu Ile Ala Met Ile Asn Ser Ser Phe Gln Glu Ile Glu Asp

725 730 735

Asp Ala Asp Val Glu Trp Lys Phe Ala Arg Ala Lys Leu Trp Phe Ser

740 745 750

Tyr Phe Glu Glu Gly Arg Thr Leu Pro Val Pro Phe Asn Leu Val Pro

755 760 765

Ser Pro Lys Ser Leu Phe Tyr Leu Leu Leu Lys Leu Lys Lys Trp Ile

770 775 780

Ser Glu Leu Phe Gln Gly His Lys Lys Gly Phe Gln Glu Asp Ala Glu

785 790 795 800

Met Asn Lys Ile Asn Glu Glu Lys Lys Leu Gly Ile Leu Gly Ser His

805 810 815

Glu Asp Leu Ser Lys Leu Ser Leu Asp Lys Lys Gln Val Gly His Asn

820 825 830

Lys Gln Pro Ser Ile Arg Ser Ser Glu Asp Phe His Leu Asn Ser Phe

835 840 845

Asn Asn Pro Pro Arg Gln Tyr Gln Lys Ile Met Lys Arg Leu Ile Lys

850 855 860

Arg Tyr Val Leu Gln Ala Gln Ile Asp Lys Glu Ser Asp Glu Val Asn

865 870 875 880

Glu Gly Glu Leu Lys Glu Ile Lys Gln Asp Ile Ser Ser Leu Arg Tyr

885 890 895

Glu Leu Leu Glu Glu Lys Ser Gln Asn Thr Glu Asp Leu Ala Glu Leu

900 905 910

Ile Arg Glu Leu Gly Glu Lys Leu Ser Met Glu Pro Asn Gln Glu Glu

915 920 925

Thr Asn Arg

930

<210>92

<400>92

000

<210>93

<211>15

<212>PRT

<213>智人(Homo sapiens)

<400>93

Ser Arg Asp Pro Pro Ala Ser Ala Ser Gln Val Thr Gly Ile Arg

1 5 10 15

<210>94

<211>396

<212>PRT

<213>智人(Homo sapiens)

<400>94

Met Ala Ser Leu Ser Arg Ala Leu Arg Val Ala Ala Ala His Pro Arg

1 5 10 15

Gln Ser Pro Thr Arg Gly Met Gly Pro Cys Asn Leu Ser Ser Ala Ala

20 25 30

Gly Pro Thr Ala Glu Lys Ser Val Pro Tyr Gln Arg Thr Leu Lys Glu

35 40 45

Gly Gln Gly Thr Ser Val Val Ala Gln Gly Pro Ser Arg Pro Leu Pro

50 55 60

Ser Thr Ala Asn Val Val Val Ile Gly Gly Gly Ser Leu Gly Cys Gln

65 70 75 80

Thr Leu Tyr His Leu Ala Lys Leu Gly Met Ser Gly Ala Val Leu Leu

85 90 95

Glu Arg Glu Arg Leu Thr Ser Gly Thr Thr Trp His Thr Ala Gly Leu

100 105 110

Leu Trp Gln Leu Arg Pro Ser Asp Val Glu Val Glu Leu Leu Ala His

115 120 125

Thr Arg Arg Val Val Ser Arg Glu Leu Glu Glu Glu Thr Gly Leu His

130 135 140

Thr Gly Trp Ile Gln Asn Gly Gly Leu Phe Ile Ala Ser Asn Arg Gln

145 150 155 160

Arg Leu Asp Glu Tyr Lys Arg Leu Met Ser Leu Gly Lys Ala Tyr Gly

165 170 175

Val Glu Ser His Val Leu Ser Pro Ala Glu Thr Lys Thr Leu Tyr Pro

180 185 190

Leu Met Asn Val Asp Asp Leu Tyr Gly Thr Leu Tyr Val Pro His Asp

195 200 205

Gly Thr Met Asp Pro Ala Gly Thr Cys Thr Thr Leu Ala Arg Ala Ala

210 215 220

Ser Ala Arg Gly Ala Gln Val Ile Glu Asn Cys Pro Val Thr Gly Ile

225 230 235 240

Arg Val Trp Thr Asp Asp Phe Gly Val Arg Arg Val Ala Gly Val Glu

245 250 255

Thr Gln His Gly Ser Ile Gln Thr Pro Cys Val Val Asn Cys Ala Gly

260 265 270

Val Trp Ala Ser Ala Val Gly Arg Met Ala Gly Val Lys Val Pro Leu

275 280 285

Val Ala Met His His Ala Tyr Val Val Thr Glu Arg Ile Glu Gly Ile

290 295 300

Gln Ser Phe Thr Leu Leu Pro Thr Leu Glu Tyr Ser Gly Thr Val Ser

305 310 315 320

Ala His Cys Asn Leu Arg Leu Pro Gly Ser Ser Asn Ser Arg Ala Ser

325 330 335

Ala Ser His Val Ala Gly Ile Lys Cys Ala Arg His His Thr Arg Leu

340 345 350

Ile Phe Phe Cys Ile Leu Val Glu Thr Glu Phe His His Val Ala Lys

355 360 365

Ala Gly Leu Glu Leu Leu Ser Ser Gly Asn Pro Pro Ile Ser Asp Phe

370 375 380

Gln Ser Ala Arg Ile Thr Gly Val Ser His His Ala

385 390 395

<210>95

<211>72

<212>PRT

<213>智人(Homo sapiens)

<400>95

Leu Leu Trp Val Leu Leu Trp Ala Thr Val Leu Gly Leu Leu Cys Gln

1 5 10 15

Arg Leu Ala Ala Arg Leu Gly Val Val Thr Gly Lys Asp Leu Gly Glu

20 25 30

Val Cys His Leu Tyr Tyr Pro Lys Ser Glu Ser Arg Ser Val Ala Gln

35 40 45

Ser Gly Val Gln Trp Cys Asp Val Ser Ser Leu Gln Pro Leu Pro Pro

50 55 60

Arg Cys Pro Ala Pro Ser Ser Gly

65 70

<210>96

<211>84

<212>PRT

<213>智人(Homo sapiens)

<400>96

Met Glu Thr Glu Ser Gly Ser Val Ala Gln Ala Gly Val Gln Trp His

1 5 10 15

Asn Leu Gly Ser Leu Gln Pro Pro Pro Ser Arg Leu Lys Gln Leu Ser

20 25 30

Tyr Leu Ser Leu Pro Ser Ser Trp Asp Tyr Arg Cys Thr Pro Pro His

35 40 45

Pro Ala Asn Phe Leu Tyr Phe Asn Arg Asp Gly Ile Ser Pro Cys Cys

50 55 60

Pro Gly Trp Ser Pro Thr Pro Lys Leu Thr Gln Ser Thr His Leu Gly

65 70 75 80

Leu Ser Lys Cys

<210>97

<211>836

<212>PRT

<213>智人(Homo sapiens)

<400>97

Met Ala Gln Phe Tyr Tyr Lys Arg Asn Val Asn Ala Pro Tyr Arg Asp

1 5 10 15

Arg Ile Pro Leu Arg Ile Val Arg Ala Glu Ser Glu Leu Ser Pro Ser

20 25 30

Glu Lys Ala Tyr Leu Asn Ala Val Glu Lys Gly Asp Tyr Ala Ser Val

35 40 45

Lys Lys Ser Leu Glu Glu Ala Glu Ile Tyr Phe Lys Ile Asn Ile Asn

50 55 60

Cys Ile Asp Pro Leu Gly Arg Thr Ala Leu Leu Ile Ala Ile Glu Asn

65 70 75 80

Glu Asn Leu Glu Leu Ile Glu Leu Leu Leu Ser Phe Asn Val Tyr Val

85 90 95

Gly Asp Ala Leu Leu His Ala Ile Arg Lys Glu Val Val Gly Ala Val

100 105 110

Glu Leu Leu Leu Asn His Lys Lys Pro Ser Gly Glu Lys Gln Val Pro

115 120 125

Pro Ile Leu Leu Asp Lys Gln Phe Ser Glu Phe Thr Pro Asp Ile Thr

130 135 140

Pro Ile Ile Leu Ala Ala His Thr Asn Asn Tyr Glu Ile Ile Lys Leu

145 150 155 160

Leu Val Gln Lys Gly Val Ser Val Pro Arg Pro His Glu Val Arg Cys

165 170 175

Asn Cys Val Glu Cys Val Ser Ser Ser Asp Val Asp Ser Leu Arg His

180 185 190

Ser Arg Ser Arg Leu Asn Ile Tyr Lys Ala Leu Ala Ser Pro Ser Leu

195 200 205

Ile Ala Leu Ser Ser Glu Asp Pro Phe Leu Thr Ala Phe Gln Leu Ser

210 215 220

Trp Glu Leu Gln Glu Leu Ser Lys Val Glu Asn Glu Phe Lys Ser Glu

225 230 235 240

Tyr Glu Glu Leu Ser Arg Gln Cys Lys Gln Phe Ala Lys Asp Leu Leu

245 250 255

Asp Gln Thr Arg Ser Ser Arg Glu Leu Glu Ile Ile Leu Asn Tyr Arg

260 265 270

Asp Asp Asn Ser Leu Ile Glu Glu Gln Ser Gly Asn Asp Leu Ala Arg

275 280 285

Leu Lys Leu Ala Ile Lys Tyr Arg Gln Lys Glu Phe Val Ala Gln Pro

290 295 300

Asn Cys Gln Gln Leu Leu Ala Ser Arg Trp Tyr Asp Glu Phe Pro Gly

305 310 315 320

Trp Arg Arg Arg His Trp Ala Val Lys Met Val Thr Cys Phe Ile Ile

325 330 335

Gly Leu Leu Phe Pro Val Phe Ser Val Cys Tyr Leu Ile Ala Pro Lys

340 345 350

Ser Pro Leu Gly Leu Phe Ile Arg Lys Pro Phe Ile Lys Phe Ile Cys

355 360 365

His Thr Ala Ser Tyr Leu Thr Phe Leu Phe Leu Leu Leu Leu Ala Ser

370 375 380

Gln His Ile Asp Arg Ser Asp Leu Asn Arg Gln Gly Pro Pro Pro Thr

385 390 395 400

Ile Val Glu Trp Met Ile Leu Pro Trp Val Leu Gly Phe Ile Trp Gly

405 410 415

Glu Ile Lys Gln Met Trp Asp Gly Gly Leu Gln Asp Tyr Ile His Asp

420 425 430

Trp Trp Asn Leu Met Asp Phe Val Met Asn Ser Leu Tyr Leu Ala Thr

435 440 445

Ile Ser Leu Lys Ile Val Ala Phe Val Lys Tyr Ser Ala Leu Asn Pro

450 455 460

Arg Glu Ser Trp Asp Met Trp His Pro Thr Leu Val Ala Glu Ala Leu

465 470 475 480

Phe Ala Ile Ala Asn Ile Phe Ser Ser Leu Arg Leu Ile Ser Leu Phe

485 490 495

Thr Ala Asn Ser His Leu Gly Pro Leu Gln Ile Ser Leu Gly Arg Met

500 505 510

Leu Leu Asp Ile Leu Lys Phe Leu Phe Ile Tyr Cys Leu Val Leu Leu

515 520 525

Ala Phe Ala Asn Gly Leu Asn Gln Leu Tyr Phe Tyr Tyr Glu Glu Thr

530 535 540

Lys Gly Leu Thr Cys Lys Gly Ile Arg Cys Glu Lys Gln Asn Asn Ala

545 550 555 560

Phe Ser Thr Leu Phe Glu Thr Leu Gln Ser Leu Phe Trp Ser Ile Phe

565 570 575

Gly Leu Ile Asn Leu Tyr Val Thr Asn Val Lys Ala Gln His Glu Phe

580 585 590

Thr Glu Phe Val Gly Ala Thr Met Phe Gly Thr Tyr Asn Val Ile Ser

595 600 605

Leu Val Val Leu Leu Asn Met Leu Ile Ala Met Met Asn Asn Ser Tyr

610 615 620

Gln Leu Ile Ala Asp His Ala Asp Ile Glu Trp Lys Phe Ala Arg Thr

625 630 635 640

Lys Leu Trp Met Ser Tyr Phe Glu Glu Gly Gly Thr Leu Pro Thr Pro

645 650 655

Phe Asn Val Ile Pro Ser Pro Lys Ser Leu Trp Tyr Leu Ile Lys Trp

660 665 670

Ile Trp Thr His Leu Cys Lys Lys Lys Met Arg Arg Lys Pro Glu Ser

675 680 685

Phe Gly Thr Ile Gly Arg Arg Ala Ala Asp Asn Leu Arg Arg His His

690 695 700

Gln Tyr Gln Glu Val Met Arg Asn Leu Val Lys Arg Tyr Val Ala Ala

705 710 715 720

Met Ile Arg Asp Ala Lys Thr Glu Glu Val Ala Arg Gln Gln Ala Ala

725 730 735

Gly Pro Leu Glu Arg Asn Ile Gln Leu Glu Ser Arg Gly Leu Ala Ser

740 745 750

Arg Gly Asp Leu Ser Ile Pro Gly Leu Ser Glu Gln Cys Val Leu Val

755 760 765

Asp His Arg Glu Arg Asn Thr Asp Thr Leu Gly Leu Gln Val Gly Lys

770 775 780

Arg Val Cys Pro Phe Lys Ser Glu Lys Val Val Val Glu Asp Thr Val

785 790 795 800

Pro Ile Ile Pro Lys Glu Lys His Ala Lys Glu Glu Asp Ser Ser Ile

805 810 815

Asp Tyr Asp Leu Asn Leu Pro Asp Thr Val Thr His Glu Asp Tyr Val

820 825 830

Thr Thr Arg Leu

835

<210>98

<211>828

<212>PRT

<213>智人(Homo sapiens)

<400>98

Met Ala Gln Phe Tyr Tyr Lys Arg Asn Val Asn Ala Pro Tyr Arg Asp

1 5 10 15

Arg Ile Pro Leu Arg Ile Val Arg Ala Glu Ser Glu Leu Ser Pro Ser

20 25 30

Glu Lys Ala Tyr Leu Asn Ala Val Glu Lys Gly Asp Tyr Ala Ser Val

35 40 45

Lys Lys Ser Leu Glu Glu Ala Glu Ile Tyr Phe Lys Ile Asn Ile Asn

50 55 60

Cys Ile Asp Pro Leu Gly Arg Thr Ala Leu Leu Ile Ala Ile Glu Asn

65 70 75 80

Glu Asn Leu Glu Leu Ile Glu Leu Leu Leu Ser Phe Asn Val Tyr Val

85 90 95

Gly Asp Ala Leu Leu His Ala Ile Arg Lys Glu Val Val Gly Ala Val

100 105 110

Glu Leu Leu Leu Asn His Lys Lys Pro Ser Gly Glu Lys Gln Val Pro

115 120 125

Pro Ile Leu Leu Asp Lys Gln Phe Ser Glu Phe Thr Pro Asp Ile Thr

130 135 140

Pro Ile Ile Leu Ala Ala His Thr Asn Asn Tyr Glu Ile Ile Lys Leu

145 150 155 160

Leu Val Gln Lys Gly Val Ser Val Pro Arg Pro His Glu Val Arg Cys

165 170 175

Asn Cys Val Glu Cys Val Ser Ser Ser Asp Val Asp Ser Leu Arg His

180 185 190

Ser Arg Ser Arg Leu Asn Ile Tyr Lys Ala Leu Ala Ser Pro Ser Leu

195 200 205

Ile Ala Leu Ser Ser Glu Asp Pro Phe Leu Thr Ala Phe Gln Leu Ser

210 215 220

Trp Glu Leu Gln Glu Leu Ser Lys Val Glu Asn Glu Phe Lys Ser Glu

225 230 235 240

Tyr Glu Glu Leu Ser Arg Gln Cys Lys Gln Phe Ala Lys Asp Leu Leu

245 250 255

Asp Gln Thr Arg Ser Ser Arg Glu Leu Glu Ile Ile Leu Asn Tyr Arg

260 265 270

Asp Asp Asn Ser Leu Ile Glu Glu Gln Ser Gly Asn Asp Leu Ala Arg

275 280 285

Leu Lys Leu Ala Ile Lys Tyr Arg Gln Lys Glu Phe Val Ala Gln Pro

290 295 300

Asn Cys Gln Gln Leu Leu Ala Ser Arg Trp Tyr Asp Glu Phe Pro Gly

305 310 315 320

Trp Arg Arg Arg His Trp Ala Val Lys Met Val Thr Cys Phe Ile Ile

325 330 335

Gly Leu Leu Phe Pro Val Phe Ser Val Cys Tyr Leu Ile Ala Pro Lys

340 345 350

Ser Pro Leu Gly Leu Phe Ile Arg Lys Pro Phe Ile Lys Phe Ile Cys

355 360 365

His Thr Ala Ser Tyr Leu Thr Phe Leu Phe Leu Leu Leu Leu Ala Ser

370 375 380

Gln His Ile Asp Arg Ser Asp Leu Asn Arg Gln Gly Pro Pro Pro Thr

385 390 395 400

Ile Val Glu Trp Met Ile Leu Pro Trp Val Leu Gly Phe Ile Trp Gly

405 410 415

Glu Ile Lys Gln Met Trp Asp Gly Gly Leu Gln Asp Tyr Ile His Asp

420 425 430

Trp Trp Asn Leu Met Asp Phe Val Met Asn Ser Leu Tyr Leu Ala Thr

435 440 445

Ile Ser Leu Lys Ile Val Ala Phe Val Lys Tyr Ser Ala Leu Asn Pro

450 455 460

Arg Glu Ser Trp Asp Met Trp His Pro Thr Leu Val Ala Glu Ala Leu

465 470 475 480

Phe Ala Ile Ala Asn Ile Phe Ser Ser Leu Arg Leu Ile Ser Leu Phe

485 490 495

Thr Ala Asn Ser His Leu Gly Pro Leu Gln Ile Ser Leu Gly Arg Met

500 505 510

Leu Leu Asp Ile Leu Lys Phe Leu Phe Ile Tyr Cys Leu Val Leu Leu

515 520 525

Ala Phe Ala Asn Gly Leu Asn Gln Leu Tyr Phe Tyr Tyr Glu Glu Thr

530 535 540

Lys Gly Leu Thr Cys Lys Gly Ile Arg Cys Glu Lys Gln Asn Asn Ala

545 550 555 560

Phe Ser Thr Leu Phe Glu Thr Leu Gln Ser Leu Phe Trp Ser Ile Phe

565 570 575

Gly Leu Ile Asn Leu Tyr Val Thr Asn Val Lys Ala Gln His Glu Phe

580 585 590

Thr Glu Phe Val Gly Ala Thr Met Phe Gly Thr Tyr Asn Val Ile Ser

595 600 605

Leu Val Val Leu Leu Asn Met Leu Ile Ala Met Met Asn Asn Ser Tyr

610 615 620

Gln Leu Ile Ala Arg Arg Ala Ala Asp Asn Leu Arg Arg His His Gln

625 630 635 640

Tyr Gln Glu Val Met Arg Asn Leu Val Lys Arg Tyr Val Ala Ala Met

645 650 655

Ile Arg Asp Ala Lys Thr Glu Glu Gly Leu Thr Glu Glu Asn Phe Lys

660 665 670

Glu Leu Lys Gln Asp Ile Ser Ser Phe Arg Phe Glu Val Leu Gly Leu

675 680 685

Leu Arg Gly Ser Lys Leu Ser Thr Ile Gln Ser Ala Asn Ala Ser Lys

690 695 700

Glu Ser Ser Asn Ser Ala Asp Ser Asp Glu Lys Ser Asp Ser Glu Glu

705 710 715 720

Glu Val Ala Arg Gln Gln Ala Ala Gly Pro Leu Gl uArg Asn Ile Gln

725 730 735

Leu Glu Ser Arg Gly Leu Ala Ser Arg Gly Asp Leu Ser Ile Pro Gly

740 745 750

Leu Ser Glu Gln Cys Val Leu Val Asp His Arg Glu Arg Asn Thr Asp

755 760 765

Thr Leu Gly Leu Gln Val Gly Lys Arg Val Cys Pro Phe Lys Ser Glu

770 775 780

Lys Val Val Val Glu Asp Thr Val Pro Ile Ile Pro Lys Glu Lys His

785 790 795 800

Ala Lys Glu Glu Asp Ser Ser Ile Asp Tyr Asp Leu Asn Leu Pro Asp

805 810 815

Thr Val Thr His Glu Asp Tyr Val Thr Thr Arg Leu

820 825

<210>99

<211>73

<212>PRT

<213>智人(Homo sapiens)

<220>

<221>MOD_RES

<222>(18)

<223>可变氨基酸

<400>99

Met Arg Thr Lys Ser Glu Arg Glu Ile His Leu Cys Val Leu Gly Phe

1 5 10 15

Phe Xaa Phe Phe Phe Glu Thr Gly Ser Arg Ser Val Ala Gln Ala Gly

20 25 30

Val Gln Arg His Ser His Gly Ser Leu Gln Pro Arg Pro Pro Gly Leu

35 40 45

Ile Gln Phe Ser His Leu Ser Leu Pro Ser Ser Trp Asp Tyr Arg His

50 55 60

Ala Pro Pro His Leu Val Asn Phe Leu

65 70

<210>100

<211>61

<212>PRT

<213>智人(Homo sapiens)

<400>100

Arg Phe Phe Phe Phe Phe Phe Phe Glu Glu Ser Arg Ser Phe Ala Gln

1 5 10 15

Ala Gly Val Gln Trp Arg Tyr Leu Gly Ser Leu Gln Pro Pro Pro Pro

20 25 30

Gly Phe Thr Arg Phe Ser Cys Leu Ser Leu Leu Ser Ser Trp Asp Tyr

35 40 45

Arg Arg Pro Pro Pro Arg Pro Ala Asn Phe Leu Tyr Phe

50 55 60

<210>101

<211>1258

<212>PRT

<213>智人(Homo sapiens)

<400>101

Glu Leu Ser Phe Pro Leu Leu Ser Leu Asp Phe Gly Ala His Gln Gly

1 5 10 15

Leu Gly Ser Ala Asp Met Gly Asp Met Lys Thr Pro Asp Phe Asp Asp

20 25 30

Leu Leu Ala Ala Phe Asp Ile Pro Asp Ile Asp Ala Asn Glu Ala Ile

35 40 45

His Ser Gly Pro Glu Glu Asn Glu Gly Pro Gly Gly Pro Gly Lys Pro

50 55 60

Glu Pro Gly Val Gly Ser Glu Ser Glu Asp Thr Ala Ala Ala Ser Ala

65 70 75 80

Gly Asp Gly Pro Gly Val Pro Ala Gln Ala Ser Asp His Gly Leu Pro

85 90 95

Pro Pro Asp Ile Ser Val Val Ser Val Ile Val Lys Asn Thr Val Cys

100 105 110

Pro Glu Gln Ser Glu Ala Leu Ala Gly Gly Ser Ala Gly Asp Gly Ala

115 120 125

Gln Ala Ala Gly Val Thr Lys Glu Gly Pro Val Gly Pro His Arg Met

130 135 140

Gln Asn Gly Phe Gly Ser Pro Glu Pro Ser Leu Pro Gly Thr Pro His

145 150 155 160

Ser Pro Ala Pro Pro Ser Gly Gly Thr Trp Lys Glu Lys Gly Met Glu

165 170 175

Gly Lys Thr Pro Leu Asp Leu Phe Ala His Phe Gly Pro Glu Pro Gly

180 185 190

Asp His Ser Asp Pro Leu Pro Pro Ser Ala Pro Ser Pro Thr Arg Glu

195 200 205

Gly Ala Leu Thr Pro Pro Pro Phe Pro Ser Ser Phe Glu Leu Ala Gln

210 215 220

Glu Asn Gly Pro Gly Met Gln Pro Pro Val Ser Ser Pro Pro Leu Gly

225 230 235 240

Ala Leu Lys Gln Glu Ser Cys Ser Pro His His Pro Gln Val Leu Ala

245 250 255

Gln Gln Gly Ser Gly Ser Ser Pro Lys Ala Thr Asp Ile Pro Ala Ser

260 265 270

Ala Ser Pro Pro Pro Val Ala Gly Val Pro Phe Phe Lys Gln Ser Pro

275 280 285

Gly His Gln Ser Pro Leu Ala Ser Pro Lys Val Pro Val Cys Gln Pro

290 295 300

Leu Lys Glu Glu Asp Asp Asp Glu Gly Pro Val Asp Lys Ser Ser Pro

305 310 315 320

Gly Ser Pro Gln Ser Pro Ser Ser Gly Ala Glu Ala Ala Asp Glu Asp

325 330 335

Ser Asn Asp Ser Pro Ala Ser Ser Ser Ser Arg Pro Leu Lys Val Arg

340 345 350

Ile Lys Thr Ile Lys Thr Ser Cys Gly Asn Ile Thr Arg Thr Val Thr

355 360 365

Gln Val Pro Ser Asp Pro Asp Pro Pro Ala Pro Leu Ala Glu Gly Ala

370 375 380

Phe Leu Ala Glu Ala Ser Leu Leu Lys Leu Ser Pro Ala Thr Pro Thr

385 390 395 400

Ser Glu Gly Pro Lys Val Val Ser Val Gln Leu Gly Asp Gly Thr Arg

405 410 415

Leu Lys Gly Thr Val Leu Pro Val Ala Thr Ile Gln Asn Ala Ser Thr

420 425 430

Ala Met Leu Met Ala Ala Ser Val Ala Arg Lys Ala Val Val Leu Pro

435 440 445

Gly Gly Thr Ala Thr Ser Pro Lys Met Ile Ala Lys Asn Val Leu Gly

450 455 460

Leu Val Pro Gln Ala Leu Pro Lys Ala Asp Gly Arg Ala Gly Leu Gly

465 470 475 480

Thr Gly Gly Gln Lys Val Asn Gly Ala Ser Val Val Met Val Gln Pro

485 490 495

Ser Lys Thr Ala Thr Gly Pro Ser Thr Gly Gly Gly Thr Val Ile Ser

500 505 510

Arg Thr Gln Ser Ser Leu Val Glu Ala Phe Asn Lys Ile Leu Asn Ser

515 520 525

Lys Asn Leu Leu Pro Ala Tyr Arg Pro Asn Leu Ser Pro Pro Ala Glu

530 535 540

Ala Gly Leu Ala Leu Pro Pro Thr Gly Tyr Arg Cys Leu Glu Cys Gly

545 550 555 560

Asp Ala Phe Ser Leu Glu Lys Ser Leu Ala Arg His Tyr Asp Arg Arg

565 570 575

Ser Met Arg Ile Glu Val Thr Cys Asn His Cys Ala Arg Arg Leu Val

580 585 590

Phe Phe Asn Lys Cys Ser Leu Leu Leu His Ala Arg Glu His Lys Asp

595 600 605

Lys Gly Leu Val Met Gln Cys Ser His Leu Val Met Arg Pro Val Ala

610 615 620

Leu Asp Gln Met Val Gly Gln Pro Asp Ile Thr Pro Leu Leu Pro Val

625 630 635 640

Ala Val Pro Pro Val Ser Gly Pro Leu Ala Leu Pro Ala Leu Gly Lys

645 650 655

Gly Glu Gly Ala Ile Thr Ser Ser Ala Ile Thr Thr Val Ala Ala Glu

660 665 670

Ala Pro Val Leu Pro Leu Ser Thr Glu Pro Pro Ala Ala Pro Ala Thr

675 680 685

Ser Ala Tyr Thr Cys Phe Arg Cys Leu Glu Cys Lys Glu Gln Cys Arg

690 695 700

Asp Lys Ala Gly Met Ala Ala His Phe Gln Gln Leu Gly Pro Pro Ala

705 710 715 720

Pro Gly Ala Thr Ser Asn Val Cys Pro Thr Cys Pro Met Met Leu Pro

725 730 735

Asn Arg Cys Ser Phe Ser Ala His Gln Arg Met His Lys Asn Arg Pro

740 745 750

Pro His Val Cys Pro Glu Cys Gly Gly Asn Phe Leu Gln Ala Asn Phe

755 760 765

Gln Thr His Leu Arg Glu Ala Cys Leu His Val Ser Arg Arg Val Gly

770 775 780

Tyr Arg Cys Pro Ser Cys Ser Val Val Phe Gly Gly Val Asn Ser Ile

785 790 795 800

Lys Ser His Ile Gln Thr Ser His Cys Glu Val Phe His Lys Cys Pro

805 810 815

Ile Cys Pro Met Ala Phe Lys Ser Gly Pro Ser Ala His Ala His Leu

820 825 830

Tyr Ser Gln His Pro Ser Phe Gln Thr Gln Gln Ala Lys Leu Ile Tyr

835 840 845

Lys Cys Ala Met Cys Asp Thr Val Phe Thr His Lys Pro Leu Leu Ser

850 855 860

Ser His Phe Asp Gln His Leu Leu Pro Gln Arg Val Ser Val Phe Lys

865 870 875 880

Cys Pro Ser Cys Pro Leu Leu Phe Ala Gln Lys Arg Thr Met Leu Glu

885 890 895

His Leu Lys Asn Thr His Gln Ser Gly Arg Leu Glu Glu Thr Ala Gly

900 905 910

Lys Gly Ala Gly Gly Ala Leu Leu Thr Pro Lys Thr Glu Pro Glu Glu

915 920 925

Leu Ala Val Ser Gln Gly Gly Ala Ala Pro Ala Thr Glu Glu Ser Ser

930 935 940

Ser Ser Ser Glu Glu Glu Glu Val Pro Ser Ser Pro Glu Pro Pro Arg

945 950 955 960

Pro Ala Lys Arg Pro Arg Arg Glu Leu Gly Ser Lys Gly Leu Lys Gly

965 970 975

Gly Gly Gly Gly Pro Gly Gly Trp Thr Cys Gly Leu Cys His Ser Trp

980 985 990

Phe Pro Glu Arg Asp Glu Tyr Val Ala His Met Lys Lys Glu His Gly

995 1000 1005

Lys Ser Val Lys Lys Phe Pro Cys Arg Leu Cys Glu Arg Ser Phe Cys

1010 1015 1020

Ser Ala Pro Ser Leu Arg Arg His Val Arg Val Asn His Glu Gly Ile

1025 1030 1035 1040

Lys Arg Val Tyr Pro Cys Arg Tyr Cys Thr Glu Gly Lys Arg Thr Phe

1045 1050 1055

Ser Ser Arg Leu Ile Leu Glu Lys His Val Gln Val Arg His Gly Leu

1060 1065 1070

Gln Leu Gly Ala Gln Ser Pro Gly Arg Gly Thr Thr Leu Ala Arg Gly

1075 1080 1085

Ser Ser Ala Arg Ala Gln Gly Pro Gly Arg Lys Arg Arg Gln Ser Ser

1090 1095 1100

Asp Ser Cys Ser Glu Glu Pro Asp Ser Thr Thr Pro Pro Ala Lys Ser

1105 1110 1115 1120

Pro Arg Gly Gly Pro Gly Ser Gly Gly His Gly Pro Leu Arg Tyr Arg

1125 1130 1135

Ser Ser Ser Ser Thr Glu Gln Ser Leu Met Met Gly Leu Arg Val Glu

1140 1145 1150

Asp Gly Ala Gln Gln Cys Leu Asp Cys Gly Leu Cys Phe Ala Ser Pro

1155 1160 1165

Gly Ser Leu Ser Arg His Arg Phe Ile Ser His Lys Lys Arg Arg Gly

1170 1175 1180

Val Gly Lys Ala Ser Ala Leu Gly Leu Gly Asp Gly Glu Glu Glu Ala

1185 1190 1195 1200

Pro Pro Ser Arg Ser Asp Pro Asp Gly Gly Asp Ser Pro Leu Pro Ala

1205 1210 1215

Ser Gly Gly Pro Leu Thr Cys Lys Val Cys Gly Lys Ser Cys Asp Ser

1220 1225 1230

Pro Leu Asn Leu Lys Thr His Phe Arg Thr His Gly Met Ala Phe Ile

1235 1240 1245

Arg Ala Arg Gln Gly Ala Val Gly Asp Asn

1250 1255

<210>102

<211>930

<212>PRT

<213>小家鼠(Mus musculus)

<400>102

Met Ser Gln Ser Pro Arg Phe Val Thr Arg Arg Gly Gly Ser Leu Lys

1 5 10 15

Ala Ala Pro Gly Ala Gly Thr Arg Arg Asn Glu Ser Gln Asp Tyr Leu

20 25 30

Leu Met Asp Glu Leu Gly Asp Asp Gly Tyr Pro Gln Leu Pro Leu Pro

35 40 45

Pro Tyr Gly Tyr Tyr Pro Ser Phe Arg Gly Asn Glu Asn Arg Leu Thr

50 55 60

His Arg Arg Gln Thr Ile Leu Arg Glu Lys Gly Arg Arg Leu Ala Asn

65 70 75 80

Arg Gly Pro Ala Tyr Met Phe Asn Asp His Ser Thr Ser Leu Ser Ile

85 90 95

Glu Glu Glu Arg Phe Leu Asp Ala Val Glu Tyr Gly Asn Ile Pro Val

100 105 110

Val Trp Lys Met Leu Glu Glu Cys His Ser Leu Asn Val Asn Cys Val

115 120 125

Asp Tyr Met Gly Gln Asn Ala Leu Gln Leu Ala Val Ala Asn Glu His

130 135 140

Leu Glu Ile Thr Glu Leu Leu Leu Lys Lys Glu Asn Leu Ser Arg Val

145 150 155 160

Gly Asp Ala Leu Leu Leu Ala Ile Ser Lys Gly Tyr Val Arg Ile Val

165 170 175

Glu Ala Ile Leu Asn His Pro Ser Phe Ala Glu Gly Lys Arg Leu Ala

180 185 190

Thr Ser Pro Ser Gln Ser Glu Leu Gln Gln Asp Asp Phe Tyr Ala Tyr

195 200 205

Asp Glu Asp Gly Thr Arg Phe Ser His Asp Val Thr Pro Ile Ile Leu

210 215 220

Ala Ala His Cys Gln Glu Tyr Glu Ile Val His Thr Leu Leu Arg Lys

225 230 235 240

Gly Ala Arg Ile Glu Arg Pro His Asp Tyr Phe Cys Lys Cys Thr Glu

245 250 255

Cys Ser Gln Lys Gln Lys His Asp Ser Phe Ser His Ser Arg Ser Arg

260 265 270

Ile Asn Ala Tyr Lys Gly Leu Ala Ser Pro Ala Tyr Leu Ser Leu Ser

275 280 285

Ser Glu Asp Pro Val Met Thr Ala Leu Glu Leu Ser Asn Glu Leu Ala

290 295 300

Val Leu Ala Asn Ile Glu Lys Glu Phe Lys Asn Asp Tyr Arg Lys Leu

305 310 315 320

Ser Met Gln Cys Lys Asp Phe Val Val Gly Leu Leu Asp Leu Cys Arg

325 330 335

Asn Thr Glu Glu Val Glu Ala Ile Leu Asn Gly Asp Ala Glu Thr Arg

340 345 350

Gln Pro Gly Asp Phe Gly Arg Pro Asn Leu Ser Arg Leu Lys Leu Ala

355 360 365

Ile Lys Asp Glu Val Lys Lys Phe Val Ala His Pro Asn Cys Gln Gln

370 375 380

Gln Leu Leu Ser Ile Trp Tyr Glu Asn Leu Ser Gly Leu Arg Gln Gln

385 390 395 400

Thr Met Ala Val Lys Phe Leu Val Val Leu Ala Val Ala Ile Gly Leu

405 410 415

Pro Phe Leu Ala Leu Ile Tyr Trp Cys Ala Pro Cys Ser Lys Met Gly

420 425 430

Lys Ile Leu Pro Arg Pro Phe Met Lys Phe Val Ala His Ala Ala Ser

435 440 445

Phe Thr Ile Phe Leu Gly Leu Leu Val Met Asn Ala Ala Asp Arg Phe

450 455 460

Glu Gly Thr Lys Leu Leu Pro Asn Glu Thr Ser Thr Asp Asn Ala Arg

465 470 475 480

Gln Leu Phe Arg Met Lys Thr Ser Cys Phe Ser Trp Met Glu Met Leu

485 490 495

Ile Ile Ser Trp Val Ile Gly Met Ile Trp Ala Glu Cys Lys Glu Ile

500 505 510

Trp Thr Gln Gly Pro Lys Glu Tyr Leu Phe Glu Leu Trp Asn Met Leu

515 520 525

Asp Phe Gly Met Leu Ala Ile Phe Ala Ala Ser Phe Ile Ala Arg Phe

530 535 540

Met Ala Phe Trp His Ala Ser Lys Ala Gln Ser Ile Ile Asp Ala Asn

545 550 555 560

Asp Thr Leu Lys Asp Leu Thr Lys Val Thr Leu Gly Asp Asn Val Lys

565 570 575

Tyr Tyr Asn Leu Ala Arg Ile Lys Trp Asp Pro Thr Asp Pro Gln Ile

580 585 590

Ile Ser Glu Gly Leu Tyr Ala Ile Ala Val Val Leu Ser Phe Ser Arg

595 600 605

Ile Ala Tyr Ile Leu Pro Ala Asn Glu Ser Phe Gly Pro Leu Gln Ile

610 615 620

Ser Leu Gly Arg Thr Val Lys Asp Ile Phe Lys Phe Met Val Ile Phe

625 630 635 640

Ile Met Val Phe Val Ala Phe Met Ile Gly Met Phe Asn Leu Tyr Ser

645 650 655

Tyr Tyr Ile Gly Ala Lys Gln Asn Glu Ala Phe Thr Thr Val Glu Glu

660 665 670

Ser Phe Lys Thr Leu Phe Trp Ala Ile Phe Gly Leu Ser Glu Val Lys

675 680 685

Ser Val Val Ile Asn Tyr Asn His Lys Phe Ile Glu Asn Ile Gly Tyr

690 695 700

Val Leu Tyr Gly Val Tyr Asn Val Thr Met Val Ile Val Leu Leu Asn

705 710 715 720

Met Leu Ile Ala Met Ile Asn Ser Ser Phe Gln Glu Ile Glu Asp Asp

725 730 735

Ala Asp Val Glu Trp Lys Phe Ala Arg Ala Lys Leu Trp Phe Ser Tyr

740 745 750

Phe Glu Glu Gly Arg Thr Leu Pro Val Pro Phe Asn Leu Val Pro Ser

755 760 765

Pro Lys Ser Leu Leu Tyr Leu Leu Leu Lys Phe Lys Lys Trp Met Cys

770 775 780

Glu Leu Ile Gln Gly Gln Lys Gln Gly Phe Gln Glu Asp Ala Glu Met

785 790 795 800

Asn Lys Arg Asn Glu Glu Lys Lys Phe Gly Ile Ser Gly Ser His Glu

805 810 815

Asp Leu Ser Lys Phe Ser Leu Asp Lys Asn Gln Leu Ala His Asn Lys

820 825 830

Gln Ser Ser Thr Arg Ser Ser Glu Asp Tyr His Leu Asn Ser Phe Ser

835 840 845

Asn Pro Pro Arg Gln Tyr Gln Lys Ile Met Lys Arg Leu Ile Lys Arg

850 855 860

Tyr Val Leu Gln Ala Gln Ile Asp Lys Glu Ser Asp Glu Val Asn Glu

865 870 875 880

Gly Glu Leu Lys Glu Ile Lys Gln Asp Ile Ser Ser Leu Arg Tyr Glu

885 890 895

Leu Leu Glu Glu Lys Ser Gln Asn Ser Glu Asp Leu Ala Glu Leu Ile

900 905 910

Arg Lys Leu Gly Glu Arg Leu Ser Leu Glu Pro Lys Leu Glu Glu Ser

915 920 925

Arg Arg

930

<210>103

<211>522

<212>PRT

<213>智人(Homo sapiens)

<400>103

Gly Phe Leu Pro Ala Thr Lys Asn Leu Leu Asn Glu Lys Asn His Gly

1 5 10 15

Val Leu His Thr Ser Val Val Leu Leu Thr Glu Met Cys Glu Arg Ser

20 25 30

Pro Asp Met Leu Ala His Phe Arg Glu Asn Glu Lys Leu Val Pro Gln

35 40 45

Leu Val Arg Ile Leu Lys Asn Leu Ile Met Ser Gly Tyr Ser Pro Gly

50 55 60

His Asp Val Ser Gly Ile Ser Asp Pro Phe Leu Gln Val Arg Ile Leu

65 70 75 80

Arg Leu Leu Arg Ile Leu Gly Arg Asn Asp Asp Asp Ser Ser Glu Ala

85 90 95

Met Asn Asp Ile Leu Ala Gln Val Ala Thr Asn Thr Glu Thr Ser Lys

100 105 110

Asn Val Gly Asn Ala Ile Leu Tyr Glu Thr Val Leu Thr Ile Met Asp

115 120 125

Ile Lys Ser Glu Ser Gly Leu Arg Val Leu Ala Ile Asn Ile Leu Gly

130 135 140

Arg Phe Leu Leu Asn Asn Asp Lys Asn Ile Arg Tyr Val Ala Leu Thr

145 150 155 160

Ser Leu Leu Lys Thr Val Gln Thr Asp His Asn Ala Val Gln Arg His

165 170 175

Arg Ser Thr Ile Val Asp Cys Leu Lys Asp Leu Asp Val Ser Ile Lys

180 185 190

Arg Arg Ala Met Glu Leu Ser Phe Ala Leu Val Asn Gly Asn Asn Ile

195 200 205

Arg Gly Met Met Lys Glu Leu Leu Tyr Phe Leu Asp Ser Cys Glu Pro

210 215 220

Glu Phe Lys Ala Asp Cys Ala Ser Gly Ile Phe Leu Ala Ala Glu Lys

225 230 235 240

Tyr Ala Pro Ser Lys Arg Trp His Ile Asp Thr Ile Met Arg Val Leu

245 250 255

Thr Thr Ala Gly Ser Tyr Val Arg Asp Asp Ala Val Pro Asn Leu Ile

260 265 270

Gln Leu Ile Thr Asn Ser Val Glu Met His Ala Tyr Thr Val Gln Arg

275 280 285

Leu Tyr Lys Ala Ile Leu Gly Asp Tyr Ser Gln Gln Pro Leu Val Gln

290 295 300

Val Ala Ala Trp Cys Ile Gly Glu Tyr Gly Asp Leu Leu Val Ser Gly

305 310 315 320

Gln Cys Glu Glu Glu Glu Pro Ile Gln Val Thr Glu Asp Glu Val Leu

325 330 335

Asp Ile Leu Glu Ser Val Leu Ile Ser Asn Met Ser Thr Ser Val Thr

340 345 350

Arg Gly Tyr Ala Leu Thr Ala Ile Met Lys Leu Ser Thr Arg Phe Thr

355 360 365

Cys Thr Val Asn Arg Ile Lys Lys Val Val Ser Ile Tyr Gly Ser Ser

370 375 380

Ile Asp Val Glu Leu Gln Arg Arg Ala Val Glu Tyr Asn Ala Leu Phe

385 390 395 400

Lys Lys Tyr Asp His Met Arg Ser Ala Leu Leu Glu Arg Met Pro Val

405 410 415

Met Glu Lys Val Thr Thr Asn Gly Pro Thr Glu Ile Val Gln Thr Asn

420 425 430

Gly Glu Thr Glu Pro Ala Pro Leu Glu Thr Lys Pro Pro Pro Ser Gly

435 440 445

Pro Gln Pro Thr Ser Gln Ala Asn Asp Leu Leu Asp Leu Leu Gly Gly

450 455 460

Asn Asp Ile Thr Pro Val Ile Pro Thr Ala Pro Thr Ser Lys Pro Ser

465 470 475 480

Ser Ala Gly Gly Glu Leu Leu Asp Leu Leu Gly Asp Ile Asn Leu Thr

485 490 495

Gly Ser His Ser Val Ser Gln Ala Gly Val Gln Trp Asp Tyr Leu Gly

500 505 510

Ser Leu Gln Pro Leu Pro Pro Ala Phe Arg

515 520

<210>104

<211>407

<212>PRT

<213>智人(Homo sapiens)

<400>104

Met Trp Pro Asn Gly Ser Ser Leu Gly Pro Cys Phe Arg Pro Thr Asn

1 5 10 15

Ile Thr Leu Glu Glu Arg Arg Leu Ile Ala Ser Pro Trp Phe Ala Ala

20 25 30

Ser Phe Cys Val Val Gly Leu Ala Ser Asn Leu Leu Ala Leu Ser Val

35 40 45

Leu Ala Gly Ala Arg Gln Gly Gly Ser His Thr Arg Ser Ser Phe Leu

50 55 60

Thr Phe Leu Cys Gly Leu Val Leu Thr Asp Phe Leu Gly Leu Leu Val

65 70 75 80

Thr Gly Thr Ile Val Val Ser Gln His Ala Ala Leu Phe Glu Trp His

85 90 95

Ala Val Asp Pro Gly Cys Arg Leu Cys Arg Phe Met Gly Val Val Met

100 105 110

Ile Phe Phe Gly Leu Ser Pro Leu Leu Leu Gly Ala Ala Met Ala Ser

115 120 125

Glu Arg Tyr Leu Gly Ile Thr Arg Pro Phe Ser Arg Pro Ala Val Ala

130 135 140

Ser Gln Arg Arg Ala Trp Ala Thr Val Gly Leu Val Trp Ala Ala Ala

145 150 155 160

Leu Ala Leu Gly Leu Leu Pro Leu Leu Gly Val Gly Arg Tyr Thr Val

165 170 175

Gln Tyr Pro Gly Ser Trp Cys Phe Leu Thr Leu Gly Ala Glu Ser Gly

180 185 190

Asp Val Ala Phe Gly Leu Leu Phe Ser Met Leu Gly Gly Leu Ser Val

195 200 205

Gly Leu Ser Phe Leu Leu Asn Thr Val Ser Val Ala Thr Leu Cys His

210 215 220

Val Tyr His Gly Gln Glu Ala Ala Gln Gln Arg Pro Arg Asp Ser Glu

225 230 235 240

Val Glu Met Met Ala Gln Leu Leu Gly Ile Met Val Val Ala Ser Val

245 250 255

Cys Trp Leu Pro Leu Leu Val Phe Ile Ala Gln Thr Val Leu Arg Asn

260 265 270

Pro Pro Ala Met Ser Pro Ala Gly Gln Leu Ser Arg Thr Thr Glu Lys

275 280 285

Glu Leu Leu Ile Tyr Leu Arg Val Ala Thr Trp Asn Gln Ile Leu Asp

290 295 300

Pro Trp Val Tyr Ile Leu Phe Arg Arg Ala Val Leu Arg Arg Leu Gln

305 310 315 320

Pro Arg Leu Ser Thr Arg Pro Arg Arg Ser Leu Thr Leu Trp Pro Ser

325 330 335

Leu Glu Tyr Ser Gly Thr Ile Ser Ala His Cys Asn Leu Arg Leu Pro

340 345 350

Gly Ser Ser Asp Ser Arg Ala Ser Ala Ser Arg Ala Ala Gly Ile Thr

355 360 365

Gly Val Ser His Cys Ala Arg Pro Cys Met Leu Phe Asp Pro Glu Phe

370 375 380

Asp Leu Leu Ala Gly Val Gln Leu Leu Pro Phe Glu Pro Pro Thr Gly

385 390 395 400

Lys Ala Leu Ser Arg Lys Asp

405

<210>105

<211>741

<212>PRT

<213>智人(Homo sapiens)

<400>105

Met Asp Ile Glu Asp Glu Glu Asn Met Ser Ser Ser Ser Thr Asp Val

1 5 10 15

Lys Glu Asn Arg Asn Leu Asp Asn Val Ser Pro Lys Asp Gly Ser Thr

20 25 30

Pro Gly Pro Gly Glu Gly Ser Gln Leu Ser Asn Gly Gly Gly Gly Gly

35 40 45

Pro Gly Arg Lys Arg Pro Leu Glu Glu Gly Ser Asn Gly His Ser Lys

50 55 60

Tyr Arg Leu Lys Lys Arg Arg Lys Thr Pro Gly Pro Val Leu Pro Lys

65 70 75 80

Asn Ala Leu Met Gln Leu Asn Glu Ile Lys Pro Gly Leu Gln Tyr Thr

85 90 95

Leu Leu Ser Gln Thr Gly Pro Val His Ala Pro Leu Phe Val Met Ser

100 105 110

Val Glu Val Asn Gly Gln Val Phe Glu Gly Ser Gly Pro Thr Lys Lys

115 120 125

Lys Ala Lys Leu His Ala Ala Glu Lys Ala Leu Arg Ser Phe Val Gln

130 135 140

Phe Pro Asn Ala Ser Glu Ala His Leu Ala Met Gly Arg Thr Leu Ser

145 150 155 160

Val Asn Thr Asp Phe Thr Ser Asp Gln Ala Asp Phe Pro Asp Thr Leu

165 170 175

Phe Asn Gly Phe Glu Thr Pro Asp Lys Ala Glu Pro Pro Phe Tyr Val

180 185 190

Gly Ser Asn Gly Asp Asp Ser Phe Ser Ser Ser Gly Asp Leu Ser Leu

195 200 205

Ser Ala Ser Pro Val Pro Ala Ser Leu Ala Gln Pro Pro Leu Pro Val

210 215 220

Leu Pro Pro Phe Pro Pro Pro Ser Gly Lys Asn Pro Val Met Ile Leu

225 230 235 240

Asn Glu Leu Arg Pro Gly Leu Lys Tyr Asp Phe Leu Ser Glu Ser Gly

245 250 255

Glu Ser His Ala Lys Ser Phe Val Met Ser Val Val Val Asp Gly Gln

260 265 270

Phe Phe Glu Gly Ser Gly Arg Asn Lys Lys Leu Ala Lys Ala Arg Ala

275 280 285

Ala Gln Ser Ala Leu Ala Ala Ile Phe Asn Leu His Leu Asp Gln Thr

290 295 300

Pro Ser Arg Gln Pro Ile Pro Ser Glu Gly Leu Gln Leu His Leu Pro

305 310 315 320

Gln Val Leu Ala Asp Ala Val Ser Arg Leu Val Leu Gly Lys Phe Gly

325 330 335

Asp Leu Thr Asp Asn Phe Ser Ser Pro His Ala Arg Arg Lys Val Leu

340 345 350

Ala Gly Val Val Met Thr Thr Gly Thr Asp Val Lys Asp Ala Lys Val

355 360 365

Ile Ser Val Ser Thr Gly Thr Lys Cys Ile Asn Gly Glu Tyr Met Ser

370 375 380

Asp Arg Gly Leu Ala Leu Asn Asp Cys His Ala Glu Ile Ile Ser Arg

385 390 395 400

Arg Ser Leu Leu Arg Phe Leu Tyr Thr Gln Leu Glu Leu Tyr Leu Asn

405 410 415

Asn Lys Asp Asp Gln Lys Arg Ser Ile Phe Gln Lys Ser Glu Arg Gly

420 425 430

Gly Phe Arg Leu Lys Glu Asn Val Gln Phe His Leu Tyr Ile Ser Thr

435 440 445

Ser Pro Cys Gly Asp Ala Arg Ile Phe Ser Pro His Glu Pro Ile Leu

450 455 460

Glu Gly Ser Arg Ser Tyr Thr Gln Ala Gly Val Gln Trp Cys Asn His

465 470 475 480

Gly Ser Leu Gln Pro Arg Pro Pro Gly Leu Leu Ser Asp Pro Ser Thr

485 490 495

Ser Thr Phe Gln Gly Ala Gly Thr Thr Glu Pro Ala Asp Arg His Pro

500 505 510

Asn Arg Lys Ala Arg Gly Gln Leu Arg Thr Lys Ile Glu Ser Gly Glu

515 520 525

Gly Thr Ile Pro Val Arg Ser Asn Ala Ser Ile Gln Thr Trp Asp Gly

530 535 540

Val Leu Gln Gly Glu Arg Leu Leu Thr Met Ser Cys Ser Asp Lys Ile

545 550 555 560

Ala Arg Trp Asn Val Val Gly Ile Gln Gly Ser Leu Leu Ser Ile Phe

565 570 575

Val Glu Pro Ile Tyr Phe Ser Ser Ile Ile Leu Gly Ser Leu Tyr His

580 585 590

Gly Asp His Leu Ser Arg Ala Met Tyr Gln Arg Ile Ser Asn Ile Glu

595 600 605

Asp Leu Pro Pro Leu Tyr Thr Leu Asn Lys Pro Leu Leu Ser Gly Ile

610 615 620

Ser Asn Ala Glu Ala Arg Gln Pro Gly Lys Ala Pro Asn Phe Ser Val

625 630 635 640

Asn Trp Thr Val Gly Asp Ser Ala Ile Glu Val Ile Asn Ala Thr Thr

645 650 655

Gly Lys Asp Glu Leu Gly Arg Ala Ser Arg Leu Cys Lys His Ala Leu

660 665 670

Tyr Cys Arg Trp Met Arg Val His Gly Lys Val Pro Ser His Leu Leu

675 680 685

Arg Ser Lys Ile Thr Lys Pro Asn Val Tyr His Glu Ser Lys Leu Ala

690 695 700

Ala Lys Glu Tyr Gln Ala Ala Lys Ala Arg Leu Phe Thr Ala Phe Ile

705 710 715 720

Lys Ala Gly Leu Gly Ala Trp Val Glu Lys Pro Thr Glu Gln Asp Gln

725 730 735

Phe Ser Leu Thr Pro

740

<210>106

<211>714

<212>PRT

<213>智人(Homo sapiens)

<400>106

Met Asp Ile Glu Asp Glu Glu Asn Met Ser Ser Ser Ser Thr Asp Val

1 5 10 15

Lys Glu Asn Arg Asn Leu Asp Asn Val Ser Pro Lys Asp Gly Ser Thr

20 25 30

Pro Gly Pro Gly Glu Gly Ser Gln Leu Ser Asn Gly Gly Gly Gly Gly

35 40 45

Pro Gly Arg Lys Arg Pro Leu Glu Glu Gly Ser Asn Gly His Ser Lys

50 55 60

Tyr Arg Leu Lys Lys Arg Arg Lys Thr Pro Gly Pro Val Leu Pro Lys

65 70 75 80

Asn Ala Leu Met Gln Leu Asn Glu Ile Lys Pro Gly Leu Gln Tyr Thr

85 90 95

Leu Leu Ser Gln Thr Gly Pro Val His Ala Pro Leu Phe Val Met Ser

100 105 110

Val Glu Val Asn Gly Gln Val Phe Glu Gly Ser Gly Pro Thr Lys Lys

115 120 125

Lys Ala Lys Leu His Ala Ala Glu Lys Ala Leu Arg Ser Phe Val Gln

130 135 140

Phe Pro Asn Ala Ser Glu Ala His Leu Ala Met Gly Arg Thr Leu Ser

145 150 155 160

Val Asn Thr Asp Phe Thr Ser Asp Gln Ala Asp Phe Pro Asp Thr Leu

165 170 175

Phe Asn Gly Phe Glu Thr Pro Asp Lys Ala Glu Pro Pro Phe Tyr Val

180 185 190

Gly Ser Asn Gly Asp Asp Ser Phe Ser Ser Ser Gly Asp Leu Ser Leu

195 200 205

Ser Ala Ser Pro Val Pro Ala Ser Leu Ala Gln Pro Pro Leu Pro Val

210 215 220

Leu Pro Pro Phe Pro Pro Pro Ser Gly Lys Asn Pro Val Met Ile Leu

225 230 235 240

Asn Glu Leu Arg Pro Gly Leu Lys Tyr Asp Phe Leu Ser Glu Ser Gly

245 250 255

Glu Ser His Ala Lys Ser Phe Val Met Ser Val Val Val Asp Gly Gln

260 265 270

Phe Phe Glu Gly Ser Gly Arg Asn Lys Lys Leu Ala Lys Ala Arg Ala

275 280 285

Ala Gln Ser Ala Leu Ala Ala Ile Phe Asn Leu His Leu Asp Gln Thr

290 295 300

Pro Ser Arg Gln Pro Ile Pro Ser Glu Gly Leu Gln Leu His Leu Pro

305 310 315 320

Gln Val Leu Ala Asp Ala Val Ser Arg Leu Val Leu Gly Lys Phe Gly

325 330 335

Asp Leu Thr Asp Asn Phe Ser Ser Pro His Ala Arg Arg Lys Val Leu

340 345 350

Ala Gly Val Val Met Thr Thr Gly Thr Asp Val Lys Asp Ala Lys Val

355 360 365

Ile Ser Val Ser Thr Gly Thr Lys Cys Ile Asn Gly Glu Tyr Met Ser

370 375 380

Asp Arg Gly Leu Ala Leu Asn Asp Cys His Ala Glu Ile Ile Ser Arg

385 390 395 400

Arg Ser Leu Leu Arg Phe Leu Tyr Thr Gln Leu Glu Leu Tyr Leu Asn

405 410 415

Asn Lys Asp Asp Gln Lys Arg Ser Ile Phe Gln Lys Ser Glu Arg Gly

420 425 430

Gly Phe Arg Leu Lys Glu Asn Val Gln Phe His Leu Tyr Ile Ser Thr

435 440 445

Ser Pro Cys Gly Asp Ala Arg Ile Phe Ser Pro His Glu Pro Ile Leu

450 455 460

Glu Gly Ser Arg Ser Tyr Thr Gln Ala Gly Val Gln Trp Cys Asn His

465 470 475 480

Gly Ser Leu Gln Pro Arg Pro Pro Gly Leu Leu Ser Asp Pro Ser Thr

485 490 495

Ser Thr Phe Gln Gly Ala Gly Thr Thr Glu Pro Ala Asp Arg His Pro

500 505 510

Asn Arg Lys Ala Arg Gly Gln Leu Arg Thr Lys Ile Glu Ser Gly Glu

515 520 525

Gly Thr Ile Pro Val Arg Ser Asn Ala Ser Ile Gln Thr Trp Asp Gly

530 535 540

Val Leu Gln Gly Glu Arg Leu Leu Thr Met Ser Cys Ser Asp Lys Ile

545 550 555 560

Ala Arg Trp Asn Val Val Gly Ile Gln Gly Ser Leu Leu Ser Ile Phe

565 570 575

Val Glu Pro Ile Tyr Phe Ser Ser Ile Ile Leu Gly Ser Leu Tyr His

580 585 590

Gly Asp His Leu Ser Arg Ala Met Tyr Gln Arg Ile Ser Asn Ile Glu

595 600 605

Asp Leu Pro Pro Leu Tyr Thr Leu Asn Lys Pro Leu Leu Ser Gly Ile

610 615 620

Ser Asn Ala Glu Ala Arg Gln Pro Gly Lys Ala Pro Asn Phe Ser Val

625 630 635 640

Asn Trp Thr Val Gly Asp Ser Ala Ile Glu Val Ile Asn Ala Thr Thr

645 650 655

Gly Lys Asp Glu Leu Gly Arg Ala Ser Arg Leu Cys Lys His Ala Leu

660 665 670

Tyr Cys Arg Trp Met Arg Val His Gly Lys Val Pro Ser His Leu Leu

675 680 685

Arg Ser Lys Ile Thr Lys Pro Asn Val Tyr His Glu Ser Lys Leu Ala

690 695 700

Ala Lys Glu Tyr Gln Ala Ala Lys Val His

705 710

<210>107

<211>76

<212>PRT

<213>智人(Homo sapiens)

<400>107

Met Glu Val Leu Leu Phe Leu Phe Ile Phe Glu Thr Glu Ser Cys Ser

1 5 10 15

Val Ile Arg Leu Glu Cys Ser Gly Ser Leu Gln Pro Pro Pro Pro Arg

20 25 30

Phe Lys Gln Phe Ser Cys Leu Ser Leu Pro Ser Ser Trp Asp Tyr Arg

35 40 45

Cys Pro Pro Pro Cys Pro Ile Asn Phe Cys Ile Phe Gly Thr Asp Arg

50 55 60

Val Ser Pro Cys Trp Pro Gly Trp Ser Arg Ser Arg

65 70 75

<210>108

<211>977

<212>PRT

<213>智人(Homo sapiens)

<400>108

Met Ala Gln Phe Tyr Tyr Lys Arg Asn Val Asn Ala Pro Tyr Arg Asp

1 5 10 15

Arg Ile Pro Leu Arg Ile Val Arg Ala Glu Ser Glu Leu Ser Pro Ser

20 25 30

Glu Lys Ala Tyr Leu Asn Ala Val Glu Lys Gly Asp Tyr Ala Ser Val

35 40 45

Lys Lys Ser Leu Glu Glu Ala Glu Ile Tyr Phe Lys Ile Asn Ile Asn

50 55 60

Cys Ile Asp Pro Leu Gly Arg Thr Ala Leu Leu Ile Ala Ile Glu Asn

65 70 75 80

Glu Asn Leu Glu Leu Ile Glu Leu Leu Leu Ser Phe Asn Val Tyr Val

85 90 95

Gly Asp Ala Leu Leu His Ala Ile Arg Lys Glu Val Val Gly Ala Val

100 105 110

Glu Leu Leu Leu Asn His Lys Lys Pro Ser Gly Glu Lys Gln Val Pro

115 120 125

Pro Ile Leu Leu Asp Lys Gln Phe Ser Glu Phe Thr Pro Asp Ile Thr

130 135 140

Pro Ile Ile Leu Ala Ala His Thr Asn Asn Tyr Glu Ile Ile Lys Leu

145 150 155 160

Leu Val Gln Lys Gly Val Ser Val Pro Arg Pro His Glu Val Arg Cys

165 170 175

Asn Cys Val Glu Cys Val Ser Ser Ser Asp Val Asp Ser Leu Arg His

180 185 190

Ser Arg Ser Arg Leu Asn Ile Tyr Lys Ala Leu Ala Ser Pro Ser Leu

195 200 205

Ile Ala Leu Ser Ser Glu Asp Pro Phe Leu Thr Ala Phe Gln Leu Ser

210 215 220

Trp Glu Leu Gln Glu Leu Ser Lys Val Glu Asn Glu Phe Lys Ser Glu

225 230 235 240

Tyr Glu Glu Leu Ser Arg Gln Cys Lys Gln Phe Ala Lys Asp Leu Leu

245 250 255

Asp Gln Thr Arg Ser Ser Arg Glu Leu Glu Ile Ile Leu Asn Tyr Arg

260 265 270

Asp Asp Asn Ser Leu Ile Glu Glu Gln Ser Gly Asn Asp Leu Ala Arg

275 280 285

Leu Lys Leu Ala Ile Lys Tyr Arg Gln Lys Glu Phe Val Ala Gln Pro

290 295 300

Asn Cys Gln Gln Leu Leu Ala Ser Arg Trp Tyr Asp Glu Phe Pro Gly

305 310 315 320

Trp Arg Arg Arg His Trp Ala Val Lys Met Val Thr Cys Phe Ile Ile

325 330 335

Gly Leu Leu Phe Pro Val Phe Ser Val Cys Tyr Leu Ile Ala Pro Lys

340 345 350

Ser Pro Leu Gly Leu Phe Ile Arg Lys Pro Phe Ile Lys Phe Ile Cys

355 360 365

His Thr Ala Ser Tyr Leu Thr Phe Leu Phe Leu Leu Leu Leu Ala Ser

370 375 380

Gln His Ile Asp Arg Ser Asp Leu Asn Arg Gln Gly Pro Pro Pro Thr

385 390 395 400

Ile Val Glu Trp Met Ile Leu Pro Trp Val Leu Gly Phe Ile Trp Gly

405 410 415

Glu Ile Lys Gln Met Trp Asp Gly Gly Leu Gln Asp Tyr Ile His Asp

420 425 430

Trp Trp Asn Leu Met Asp Phe Val Met Asn Ser Leu Tyr Leu Ala Thr

435 440 445

Ile Ser Leu Lys Ile Val Ala Phe Val Lys Tyr Ser Ala Leu Asn Pro

450 455 460

Arg Glu Ser Trp Asp Met Trp His Pro Thr Leu Val Ala Glu Ala Leu

465 470 475 480

Phe Ala Ile Ala Asn Ile Phe Ser Ser Leu Arg Leu Ile Ser Leu Phe

485 490 495

Thr Ala Asn Ser His Leu Gly Pro Leu Gln Ile Ser Leu Gly Arg Met

500 505 510

Leu Leu Asp Ile Leu Lys Phe Leu Phe Ile Tyr Cys Leu Val Leu Leu

515 520 525

Ala Phe Ala Asn Gly Leu Asn Gln Leu Tyr Phe Tyr Tyr Glu Glu Thr

530 535 540

Lys Gly Leu Thr Cys Lys Gly Ile Arg Cys Glu Lys Gln Asn Asn Ala

545 550 555 560

Phe Ser Thr Leu Phe Glu Thr Leu Gln Ser Leu Phe Trp Ser Ile Phe

565 570 575

Gly Leu Ile Asn Leu Tyr Val Thr Asn Val Lys Ala Gln His Glu Phe

580 585 590

Thr Glu Phe Val Gly Ala Thr Met Phe Gly Thr Tyr Asn Val Ile Ser

595 600 605

Leu Val Val Leu Leu Asn Met Leu Ile Ala Met Met Asn Asn Ser Tyr

610 615 620

Gln Leu Ile Ala Asp His Ala Asp Ile Glu Trp Lys Phe Ala Arg Thr

625 630 635 640

Lys Leu Trp Met Ser Tyr Phe Glu Glu Gly Gly Thr Leu Pro Thr Pro

645 650 655

Phe Asn Val Ile Pro Ser Pro Lys Ser Leu Trp Tyr Leu Ile Lys Trp

660 665 670

Ile Trp Thr His Leu Cys Lys Lys Lys Met Arg Arg Lys Pro Glu Ser

675 680 685

Phe Gly Thr Ile Gly Arg Arg Ala Ala Asp Asn Leu Arg Arg His His

690 695 700

Gln Tyr Gln Glu Val Met Arg Asn Leu Val Lys Arg Tyr Val Ala Ala

705 710 715 720

Met Ile Arg Asp Ala Lys Thr Glu Glu Gly Leu Thr Glu Glu Asn Phe

725 730 735

Lys Glu Leu Lys Gln Asp Ile Ser Ser Phe Arg Phe Glu Val Leu Gly

740 745 750

Leu Leu Arg Gly Ser Lys Leu Ser Thr Ile Gln Ser Ala Asn Ala Ser

755 760 765

Lys Glu Ser Ser Asn Ser Ala Asp Ser Asp Glu Lys Ser Asp Ser Glu

770 775 780

Gly Asn Ser Lys Asp Lys Lys Lys Asn Phe Ser Leu Phe Asp Leu Thr

785 790 795 800

Thr Leu Ile His Pro Arg Ser Ala Ala Ile Ala Ser Glu Arg His Asn

805 810 815

Ile Ser Asn Gly Ser Ala Leu Val Val Gln Glu Pro Pro Arg Glu Lys

820 825 830

Gln Arg Lys Val Asn Phe Val Thr Asp Ile Lys Asn Phe Gly Leu Phe

835 840 845

His Arg Arg Ser Lys Gln Asn Ala Ala Glu Gln Asn Ala Asn Gln Ile

850 855 860

Phe Ser Val Ser Glu Glu Val Ala Arg Gln Gln Ala Ala Gly Pro Leu

865 870 875 880

Glu Arg Asn Ile Gln Leu Glu Ser Arg Gly Leu Ala Ser Arg Gly Asp

885 890 895

Leu Ser Ile Pro Gly Leu Ser Glu Gln Cys Val Leu Val Asp His Arg

900 905 910

Glu Arg Asn Thr Asp Thr Leu Gly Leu Gln Val Gly Lys Arg Val Cys

915 920 925

Pro Phe Lys Ser Glu Lys Val Val Val Glu Asp Thr Val Pro Ile Ile

930 935 940

Pro Lys Glu Lys His Ala Lys Glu Glu Asp Ser Ser Ile Asp Tyr Asp

945 950 955 960

Leu Asn Leu Pro Asp Thr Val Thr His Glu Asp Tyr Val Thr Thr Arg

965 970 975

Leu

<210>109

<211>275

<212>PRT

<213>智人(Homo sapiens)

<400>109

Met Glu Ser Tyr Ser Val Thr Gln Ala Gly Val Gln Trp His Glu Leu

1 5 10 15

Cys Ser Leu Gln Pro Ser Pro Pro Arg Phe Arg Glu Met Cys Ile Glu

20 25 30

Gln Asp Gly Arg Val His Leu Thr Val Val Tyr Phe Gly Lys Glu Glu

35 40 45

Ile Asn Glu Val Lys Gly Val Leu Glu Asn Thr Ser Lys Ala Ala Asn

50 55 60

Phe Arg Asn Phe Thr Phe Ile Gln Leu Asn Gly Glu Phe Ser Arg Gly

65 70 75 80

Lys Gly Leu Asp Val Gly Ala Arg Phe Trp Lys Gly Ser Asn Val Leu

85 90 95

Leu Phe Phe Cys Asp Val Asp Ile Tyr Phe Thr Ser Glu Phe Leu Asn

100 105 110

Thr Cys Arg Leu Asn Thr Gln Pro Gly Lys Lys Val Phe Tyr Pro Val

115 120 125

Leu Phe Ser Gln Tyr Asn Pro Gly Ile Ile Tyr Gly His His Asp Ala

130 135 140

Val Pro Pro Leu Glu Gln Gln Leu Val Ile Lys Lys Glu Thr Gly Phe

145 150 155 160

Trp Arg Asp Phe Gly Phe Gly Met Thr Cys Gln Tyr Arg Ser Asp Phe

165 170 175

Ile Asn Ile Gly Gly Phe Asp Leu Asp Ile Lys Gly Trp Gly Gly Glu

180 185 190

Asp Val His Leu Tyr Arg Lys Tyr Leu His Ser Asn Leu Ile Val Val

195 200 205

Arg Thr Pro Val Arg Gly Leu Phe His Leu Trp His Glu Lys Arg Cys

210 215 220

Met Asp Glu Leu Thr Pro Glu Gln Tyr Lys Met Cys Met Gln Ser Lys

225 230 235 240

Ala Met Asn Glu Ala Ser His Gly Gln Leu Gly Met Leu Val Phe Arg

245 250 255

His Glu Ile Glu Ala His Leu Arg Lys Gln Lys Gln Lys Thr Ser Ser

260 265 270

Lys Lys Thr

275

<210>110

<211>1084

<212>PRT

<213>智人(Homo sapiens)

<400>110

Met Asp Ile Thr Leu Val Arg Lys Glu Leu Gln Glu Leu Gln Asn Leu

1 5 10 15

Tyr Lys Gln Asn Ser Thr His Thr Ala Gln Gln Ala Glu Leu Ile Gln

20 25 30

Gln Leu Gln Val Leu Asn Met Asp Thr Gln Lys Val Leu Arg Asn Gln

35 40 45

Glu Asp Val His Thr Ala Glu Ser Ile Ser Tyr Gln Lys Leu Tyr Asn

50 55 60

Glu Leu His Ile Cys Phe Glu Thr Thr Lys Ser Asn Glu Ala Met Leu

65 70 75 80

Arg Gln Ser Val Thr Asn Leu Gln Asp Gln Leu Leu Gln Lys Glu Gln

85 90 95

Glu Asn Ala Lys Leu Lys Glu Lys Leu Gln Glu Ser Gln Gly Ala Pro

100 105 110

Leu Pro Leu Pro Gln Glu Ser Asp Pro Asp Tyr Ser Ala Gln Val Pro

115 120 125

His Arg Pro Ser Leu Ser Ser Leu Glu Thr Leu Met Val Ser Gln Lys

130 135 140

Ser Glu Ile Glu Tyr Leu Gln Glu Lys Leu Lys Ile Ala Asn Glu Lys

145 150 155 160

Leu Ser Glu Asn Ile Ser Ala Asn Lys Gly Phe Ser Arg Lys Ser Ile

165 170 175

Met Thr Ser Ala Glu Gly Lys His Lys Glu Pro Pro Val Lys Arg Ser

180 185 190

Arg Ser Leu Ser Pro Lys Ser Ser Phe Thr Asp Ser Glu Glu Leu Gln

195 200 205

Lys Leu Arg Lys Ala Glu Arg Lys Ile Glu Asn Leu Glu Lys Ala Leu

210 215 220

Gln Leu Lys Ser Gln Glu Asn Asp Glu Leu Arg Asp Ala His Glu Lys

225 230 235 240

Arg Lys Glu Arg Leu Gln Met Leu Gln Thr Asn Tyr Arg Ala Val Lys

245 250 255

Glu Gln Leu Lys Gln Trp Glu Glu Gly Ser Gly Met Thr Glu Ile Arg

260 265 270

Lys Ile Lys Arg Ala Asp Pro Gln Gln Leu Arg Gln Glu Asp Ser Asp

275 280 285

Ala Val Trp Asn Glu Leu Ala Tyr Phe Lys Arg Glu Asn Gln Glu Leu

290 295 300

Met Ile Gln Lys Met Asn Leu Glu Glu Glu Leu Asp Glu Leu Lys Val

305 310 315 320

His Ile Ser Ile Asp Lys Ala Ala Ile Gln Glu Leu Asn Arg Cys Val

325 330 335

Ala Glu Arg Arg Glu Glu Gln Leu Phe Arg Ser Gly Glu Asp Asp Glu

340 345 350

Val Lys Arg Ser Thr Pro Glu Lys Asn Gly Lys Glu Met Leu Glu Gln

355 360 365

Thr Leu Gln Lys Val Ile Glu Leu Glu Asn Arg Leu Lys Ser Phe Glu

370 375 380

Lys Arg Ser Arg Lys Leu Lys Glu Gly Asn Lys Lys Leu Met Lys Glu

385 390 395 400

Asn Asp Phe Leu Lys Ser Leu Leu Lys Gln Gln Gln Glu Asp Thr Glu

405 410 415

Thr Arg Glu Lys Glu Leu Glu Gln Ile Ile Lys Gly Ser Lys Asp Val

420 425 430

Glu Lys Glu Asn Thr Glu Leu Gln Val Lys Ile Ser Glu Leu Glu Thr

435 440 445

Glu Val Thr Ser Leu Arg Arg Gln Val Ala Glu Ala Asn Ala Leu Arg

450 455 460

Asn Glu Asn Glu Glu Leu Ile Asn Pro Met Glu Lys Ser His Gln Ser

465 470 475 480

Ala Asp Arg Ala Lys Ser Glu Met Ala Thr Met Lys Val Arg Ser Gly

485 490 495

Arg Tyr Asp Cys Lys Thr Thr Met Thr Lys Val Lys Phe Lys Ala Ala

500 505 510

Lys Lys Asn Cys Ser Val Gly Arg His His Thr Val Leu Asn His Ser

515 520 525

Ile Lys Val Met Ser Asn Val Phe Glu Asn Leu Ser Lys Asp Gly Trp

530 535 540

Glu Asp Val Ser Glu Ser Ser Ser Asp Ser Glu Ala Gln Thr Ser Gln

545 550 555 560

Thr Leu Gly Thr Ile Ile Val Glu Thr Ser Gln Lys Ile Ser Pro Thr

565 570 575

Glu Asp Gly Lys Asp Gln Lys Glu Ser Asp Pro Thr Glu Asp Ser Gln

580 585 590

Thr Gln Gly Lys Glu Ile Val Gln Thr Tyr Leu Asn Ile Asp Gly Lys

595 600 605

Thr Pro Lys Asp Tyr Phe His Asp Lys Asn Ala Lys Lys Pro Thr Phe

610 615 620

Gln Lys Lys Asn Cys Lys Met Gln Lys Ser Ser His Thr Ala Val Pro

625 630 635 640

Thr Arg Val Asn Arg Glu Lys Tyr Lys Asn Ile Thr Ala Gln Lys Ser

645 650 655

Ser Ser Asn Ile Ile Leu Leu Arg Glu Arg Ile Ile Ser Leu Gln Gln

660 665 670

Gln Asn Ser Val Leu Gln Asn Ala Lys Lys Thr Ala Glu Leu Ser Val

675 680 685

Lys Glu Tyr Lys Glu Val Asn Glu Lys Leu Leu His Gln Gln Gln Val

690 695 700

Ser Asp Gln Arg Phe Gln Thr Ser Arg Gln Thr Ile Lys Lys Leu Asn

705 710 715 720

Leu Asp Leu Ala Gly Leu Arg Lys Glu Lys Glu Asp Leu Leu Lys Lys

725 730 735

Leu Glu Ser Ser Ser Glu Ile Thr Ser Leu Ala Glu Glu Asn Ser Gln

740 745 750

Val Thr Phe Pro Arg Ile Gln Val Thr Ser Leu Ser Pro Ser Arg Ser

755 760 765

Met Asp Leu Glu Met Lys Gln Leu Gln Tyr Lys Leu Lys Asn Ala Thr

770 775 780

Asn Glu Leu Thr Lys Gln Ser Ser Asn Val Lys Thr Leu Lys Phe Glu

785 790 795 800

Leu Leu Ala Lys Glu Glu His Ile Lys Glu Met His Glu Lys Ile Ser

805 810 815

Arg Met Glu Arg Asp Ile Thr Met Lys Arg His Leu Ile Glu Asp Leu

820 825 830

Lys Phe Arg Gln Lys Val Asn Leu Glu Ser Asn Lys Ser Phe Ser Glu

835 840 845

Met Leu Gln Asn Leu Asp Lys Lys Val Lys Thr Leu Thr Glu Glu Cys

850 855 860

Ser Asn Lys Lys Val Ser Ile Asp Ser Leu Lys Gln Arg Leu Asn Val

865 870 875 880

Ala Val Lys Glu Lys Ser Gln Tyr Glu Gln Met Tyr Gln Lys Ser Lys

885 890 895

Glu Glu Leu Glu Lys Lys Asp Leu Lys Leu Thr Leu Leu Val Ser Arg

900 905 910

Ile Ser Glu Thr Glu Ser Ala Met Ala Glu Ile Glu Thr Ala Ala Ser

915 920 925

Lys Gln Leu Gln Glu Leu Ala Leu Gln Ser Glu Gln Val Leu Glu Gly

930 935 940

Ala Gln Lys Thr Leu Leu Leu Ala Asn Glu Lys Val Glu Glu Phe Thr

945 950 955 960

Thr Phe Val Lys Ala Leu Ala Lys Glu Leu Gln Asn Asp Val His Val

965 970 975

Val Arg Arg Gln Ile Arg Glu Leu Lys Lys Met Lys Lys Asn Arg Asp

980 985 990

Ala Cys Lys Thr Ser Thr His Lys Ala Gln Thr Leu Ala Ala Ser Ile

995 1000 1005

Leu Asn Ile Ser Arg Ser Asp Leu Glu Glu Ile Leu Asp Thr Glu Asp

1010 1015 1020

Gln Val Glu Ile Glu Lys Thr Lys Ile Asp Ala Glu Asn Asp Lys Glu

1025 1030 1035 1040

Trp Met Leu Tyr Ile Gln Lys Leu Leu Glu Gly Gln Ser Leu Thr Leu

1045 1050 1055

Ser Pro Arg Leu Lys Cys Asn Gly Ala Ile Met Ala His Gln Asn Leu

1060 1065 1070

Arg Leu Pro Asp Ser Ser Ser Ser Ala Ser Ala Ser

1075 1080

<210>111

<211>687

<212>PRT

<213>智人(Homo sapiens)

<400>111

Met Lys Val Val Pro Glu Lys Asn Ala Val Arg Ile Leu Trp Gly Arg

1 5 10 15

Glu Arg Gly Ala Arg Ala Met Gly Ala Gln Arg Leu Leu Gln Glu Leu

20 25 30

Val Glu Asp Lys Thr Arg Trp Met Lys Trp Glu Gly Lys Arg Val Glu

35 40 45

Leu Pro Asp Ser Pro Arg Ser Thr Phe Leu Leu Ala Phe Ser Pro Asp

50 55 60

Arg Thr Leu Leu Ala Ser Thr His Val Asn His Asn Ile Tyr Ile Thr

65 70 75 80

Glu Val Lys Thr Gly Lys Cys Val His Ser Leu lle Gly His Arg Arg

85 90 95

Thr Pro Trp Cys Val Thr Phe His Pro Thr Ile Ser Gly Leu Ile Ala

100 105 110

Ser Gly Cys Leu Asp Gly Glu Val Arg Ile Trp Asp Leu His Gly Gly

115 120 125

Ser Glu Ser Trp Phe Thr Asp Ser Asn Asn Ala Ile Ala Ser Leu Ala

130 135 140

Phe His Pro Thr Ala Gln Leu Leu Leu Ile Ala Thr Ala Asn Glu Ile

145 150 155 160

His Phe Trp Asp Arg Ser Arg Arg Glu Pro Phe Ala Val Val Lys Thr

165 170 175

Ala Ser Glu Met Glu Arg Val Arg Leu Val Arg Phe Asp Pro Leu Gly

180 185 190

His Tyr Leu Leu Thr Ala Ile Val Asn Pro Ser Asn Gln Gln Gly Asp

195 200 205

Asp Glu Pro Glu Ile Pro Ile Asp Gly Thr Glu Leu Ser His Tyr Arg

210 215 220

Gln Arg Ala Leu Leu Gln Ser Gln Pro Val Arg Arg Thr Pro Leu Leu

225 230 235 240

His Asn Phe Leu His Met Leu Ser Ser Arg Ser Ser Gly Ile Gln Thr

245 250 255

Glu Pro Phe His Pro Pro Glu Gln Ala Ser Ser Thr Gln Gln Asp Gln

260 265 270

Gly Leu Leu Asn Arg Pro Ser Ala Phe Ser Thr Val Gln Ser Ser Thr

275 280 285

Ala Gly Asn Thr Leu Arg Asn Leu Ser Leu Gly Pro Thr Arg Arg Ser

290 295 300

Leu Gly Gly Pro Leu Ser Ser His Pro Ser Arg Tyr His Arg Glu Ile

305 310 315 320

Ala Pro Gly Leu Thr Gly Ser Glu Trp Thr Arg Thr Val Leu Ser Leu

325 330 335

Asn Ser Arg Ser Glu Ala Glu Ser Met Pro Pro Pro Arg Thr Ser Ala

340 345 350

Ser Ser Val Ser Leu Leu Ser Val Leu Arg Gln Gln Glu Gly Gly Ser

355 360 365

Gln Ala Ser Val Tyr Thr Ser Ala Thr Glu Gly Arg Gly Phe Pro Ala

370 375 380

Ser Gly Leu Ala Thr Glu Ser Asp Gly Gly Asn Gly Ser Ser Gln Asn

385 390 395 400

Asn Ser Gly Ser Ile Arg His Glu Leu Gln Cys Asp Leu Arg Arg Phe

405 410 415

Phe Leu Glu Tyr Asp Arg Leu Gln Glu Leu Asp Gln Ser Leu Ser Gly

420 425 430

Glu Ala Pro Gln Thr Gln Gln Ala Gln Glu Met Leu Asn Asn Asn Ile

435 440 445

Glu Ser Glu Arg Pro Gly Pro Ser His Gln Pro Thr Pro His Ser Ser

450 455 460

Glu Asn Asn Ser Asn Leu Ser Arg Gly His Leu Asn Arg Cys Arg Ala

465 470 475 480

Cys His Asn Leu Leu Thr Phe Asn Asn Asp Thr Leu Arg Trp Glu Arg

485 490 495

Thr Thr Pro Asn Tyr Ser Ser Gly Glu Ala Ser Ser Ser Trp Gln Val

500 505 510

Pro Ser Ser Phe Glu Ser Val Pro Ser Ser Gly Ser Gln Leu Pro Pro

515 520 525

Leu Glu Arg Thr Glu Gly Gln Thr Pro Ser Ser Ser Arg Leu Glu Leu

530 535 540

Ser Ser Ser Ala Ser Pro Gln Glu Glu Arg Thr Val Gly Val Ala Phe

545 550 555 560

Asn Gln Glu Thr Gly His Trp Glu Arg Ile Tyr Thr Gln Ser Ser Arg

565 570 575

Ser Gly Thr Val Ser Gln Glu Ala Leu His Gln Asp Met Pro Glu Glu

580 585 590

Ser Ser Glu Glu Asp Ser Leu Arg Arg Arg Ser Leu Ala Leu Ser Pro

595 600 605

Arg Leu Glu Tyr Ser Gly Ala Ile Leu Ala His Cys Lys Leu Arg Leu

610 615 620

Pro Gly Ser Cys His Ser Pro Ala Ser Ala Ser Gln Val Ala Gly Thr

625 630 635 640

Thr Gly Ala His His His Ala Arg Leu Ile Phe Ala Phe Leu Val Glu

645 650 655

Met Glu Phe His His Val Ser Gln Ala Gly Leu Glu Leu Leu Thr Ser

660 665 670

Gly Asp Leu Pro Thr Ser Ala Ser Gln Val Leu Gly Leu Gln Ala

675 680 685

<210>112

<211>152

<212>PRT

<213>智人(Homo sapiens)

<400>112

Met Val His Ser Pro Arg Ser Leu Val Ala Asn Pro Ser Gln Val Leu

1 5 10 15

Phe Phe Leu Ser Phe Leu Phe Phe Phe Phe Leu Arg Gln Ser Phe Ala

20 25 30

Leu Val Ala Gln Ala Gly Val Gln Trp Arg Asn Leu Gly Ser Leu Gln

35 40 45

Pro Pro Pro Pro Gly Phe Lys Gln Phe Ser Cys Leu Ser Leu Leu Ser

50 55 60

Ser Trp Asp Tyr Arg His Ala Pro Pro Cys Pro Ala Tyr Phe Val Phe

65 70 75 80

Leu Val Asp Met Gly Phe Pro His Val Gly Gln Thr Gly Leu Glu Leu

85 90 95

Leu Thr Ser Gly Asp Pro Pro Ala Ser Ala Ser Gln Ser Ala Gly Ile

100 105 110

Thr Gly Gly Ser His Arg Ala Gln Pro Thr Ser Ser Asn Pro Tyr Gly

115 120 125

Ile Val Phe Phe Phe Leu Pro Val Lys Thr Phe Ser Gly Met Ser Gln

130 135 140

Glu Ala Gly Asp Cys Arg Glu Thr

145 150

<210>113

<211>239

<212>PRT

<213>智人(Homo sapiens)

<400>113

Met Pro Thr Ala Thr Gly Leu Thr Leu Leu Thr Ser Ala Ser Ser Ala

1 5 10 15

Ile Ser Asp Pro Gly Gly Glu Val Ser Ala Pro Trp Gly Gly Leu Arg

20 25 30

Thr Trp Thr Gln Pro Leu Arg Cys Trp Glu Arg Leu Leu Pro Pro Pro

35 40 45

Gly Asp Pro Arg Thr Val Ala Glu Asn Thr Gln Gln Asp Glu Cys Gly

50 55 60

Leu Pro Gly Ser Cys Pro Ala Arg Pro Leu Ser Arg Lys Pro Glu Cys

65 70 75 80

Gly Arg Glu Gly Ile Leu Pro Cys Cys Ser Ser Ser Ala Trp Pro Glu

85 90 95

Gly Ser Phe Arg Pro Phe Gln Met Asn Leu Phe Ser Phe Leu Ser Phe

100 105 110

Phe Phe Leu Phe Phe Phe Phe Leu Arg Trp Ser Leu Thr Leu Ser Pro

115 120 125

Arg Leu Glu Cys Ser Ser Ala Ile 5er Ala His Cys Asn Leu Arg Leu

130 135 140

Pro Gly Ser Ser Asn Ser Pro Ala Leu Ala Ser Gln Val Ala Gly Ile

145 150 155 160

Thr Gly Ile Cys His His Ala Arg Gln Ile Phe Val Phe Leu Val Glu

165 170 175

Thr Gly Phe Cys His Val Gly Gln Ala Gly Leu Glu Leu Leu Ile Ser

180 185 190

Gly Asp Ser Pro Ala Ser Ala Phe Gln Ser Ala Gly Ile Ile Gly Val

195 200 205

Ser His Arg Ala Arg Pro Gly Ser Val Phe Leu Ala Arg Ser Glu Glu

210 215 220

Ser Leu Tyr Leu Arg Pro Gly Gln Gln Ser Gln Glu Val Lys Val

225 230 235

<210>114

<211>181

<212>PRT

<213>智人(Homo sapiens)

<400>114

Met Leu Leu Val Asp Ala Asp Gln Pro Glu Pro Met Arg Ser Gly Ala

1 5 10 15

Arg Glu Leu Ala Leu Phe Leu Thr Pro Glu Pro Gly Ala Glu Ala Lys

20 25 30

Glu Val Glu Glu Thr Ile Glu Gly Met Leu Leu Arg Leu Glu Glu Phe

35 40 45

Cys Ser Leu Ala Asp Leu Ile Arg Ser Asp Thr Ser Gln Ile Leu Glu

50 55 60

Glu Asn Ile Pro Val Leu Lys Ala Lys Leu Thr Glu Met Arg Gly Ile

65 70 75 80

Tyr Ala Lys Val Asp Arg Leu Glu Ala Phe Val Lys Met Val Gly His

85 90 95

His Val Ala Phe Leu Glu Ala Asp Val Leu Gln Ala Glu Arg Asp His

100 105 110

Gly Ala Phe Pro Gln Ala Leu Arg Arg Trp Leu Gly Ser Ala Gly Leu

115 120 125

Pro Ser Phe Arg Asn Val Glu Cys Ser Gly Thr Ile Pro Ala Arg Cys

130 135 140

Asn Leu Arg Leu Pro Gly Ser Ser Asp Ser Pro Ala Ser Ala Ser Gln

145 150 155 160

Val Ala Gly Ile Thr Glu Val Thr Cys Thr Gly Ala Arg Asp Val Arg

165 170 175

Ala Ala His Thr Val

180

<210>115

<211>208

<212>PRT

<213>智人(Homo sapiens)

<400>115

Met Ser Val Tyr Ser Gly Lys Val Leu Leu Gln Thr Thr Pro Pro His

1 5 10 15

Val Ile Gly Gln Leu Asp Lys Leu Ile Arg Glu Val Ser Thr Leu Asp

20 25 30

Gly Val Leu Glu Val Arg Asn Glu His Phe Trp Thr Leu Gly Phe Gly

35 40 45

Ser Leu Ala Gly Ser Val His Val Arg Ile Arg Arg Asp Ala Asn Glu

50 55 60

Gln Met Val Leu Ala His Val Thr Asn Arg Leu Tyr Thr Leu Val Ser

65 70 75 80

Thr Leu Thr Val Gln Ile Phe Lys Asp Asp Trp Ile Arg Pro Ala Leu

85 90 95

Leu Ser Gly Pro Val Ala Ala Asn Val Leu Asn Phe Ser Asp His His

100 105 110

Val Ile Pro Met Pro Leu Leu Lys Gly Thr Asp Gly Leu Asn Pro Tyr

115 120 125

Val His Phe Leu Trp Lys Ile Asn Phe Phe Leu Phe Phe Asp Met Glu

130 135 140

Ser Leu Ser Val Ala Gln Ala Gly Val Gln Trp His Asp Leu Gly Ser

145 150 155 160

Leu Gln Pro His Leu Pro Gly Ser Ser Asn Ser Ala Cys Leu Ser Leu

165 170 175

Pro Ser Ser Trp Asp Tyr Arg His Ala Pro Pro His Leu Pro Asn Phe

180 185 190

Cys Ile Ile Ser Lys Asp Gly Val Leu Pro Cys Trp Pro Cys Trp Ser

195 200 205

<210>116

<211>118

<212>PRT

<213>智人(Homo sapiens)

<400>116

Met Glu Ser Arg Ser Val Ala Gln Thr Gly Val His Trp His Asn Leu

1 5 10 15

Ser Ser Leu Gln Pro Leu Pro Pro Arg Phe Lys Gln Phe Ser Cys Leu

20 25 30

Ser Leu Arg Ser Ser Trp Asp Tyr Thr His Leu Pro Pro Cys Leu Ala

35 40 45

Asn Phe Phe Val Phe Leu Val Glu Thr Ala Phe Arg His Val Gly Gln

50 55 60

Ala Gly Leu Lys Leu Leu Thr Ser Gly Asp Gln Pro Thr Ser Ala Ser

65 70 75 80

Gln Ser Ala Gly Ile Thr Gly Ile Ser His Arg Thr Gln Pro Val Gly

85 90 95

Arg Phe Leu Ile Thr Asp Ser Ile Phe Leu Phe Val Thr Asp Leu Leu

100 105 110

Lys Phe Ser Ile Ser Ser

115

<210>117

<211>102

<212>PRT

<213>智人(Homo sapiens)

<400>117

Met Ser Lys Val Leu Gly Gly Pro Phe Ser Lys Gly His Thr Ala Ser

1 5 10 15

Asp Lys Tyr Phe Gln Ile Phe His Asn Ile Ser Phe Phe Glu Thr Glu

20 25 30

Ser Cys Ser Val Ala Gln Ala Gly Val Gln Trp Cys Asn Leu Gly Ser

35 40 45

Leu Gln Ala Leu Pro Pro Arg Phe Thr Pro Phe Ser Cys Leu Ser Leu

50 55 60

Pro Ser Ser Trp Asp Tyr Arg His Pro Pro Pro Cys Pro Asp Asn Val

65 70 75 80

Phe Val Phe Ser Val Glu Thr Gly Phe His Cys Val Ser Gln Asp Gly

85 90 95

Leu Asn Leu Leu Thr Leu

100

<210>118

<211>214

<212>PRT

<213>智人(Homo sapiens)

<400>118

Met Ala Gln Gly Thr Leu Ile Arg Val Thr Pro Glu Gln Pro Thr His

1 5 10 15

Ala Val Cys Val Leu Gly Thr Leu Thr Gln Leu Asp Ile Cys Ser Ser

20 25 30

Ala Pro Glu Asp Cys Thr Ser Phe Ser Ile Asn Ala Ser Pro Gly Val

35 40 45

Val Val Asp Ile Ala His Ser Pro Pro Ala Lys Lys Lys Ser Thr Gly

50 55 60

Ser Ser Thr Trp Pro Leu Asp Pro Gly Val Glu Val Thr Leu Thr Met

65 70 75 80

Lys Ala Ala Ser Gly Ser Thr Gly Asp Gln Lys Val Gln Ile Ser Tyr

85 90 95

Tyr Gly Pro Lys Thr Pro Pro Val Lys Ala Leu Leu Tyr Leu Thr Ala

100 105 110

Val Asp Gly Val Ser Pro Cys His Pro Gly Trp Ser Ala Met His Asp

115 120 125

Leu Ala His Cys Asn Leu Arg Leu Gln Val Gln Ala Ile Leu Cys Phe

130 135 140

Ser Val Pro Ser Ser Trp Thr Thr Gly Ala Cys His His Ala Trp Leu

145 150 155 160

Ile Phe Val Phe Leu Val Glu Met Glu Phe His His Val Gly Gln Ala

165 170 175

Gly Leu Glu Leu Leu Thr Ser Gly Asp Leu Pro Ala Ser Gly Ser Gln

180 185 190

Ser Ala Arg Ile Thr Gly Met Asn His Cys Ala Arg Pro Ser Ile Phe

195 200 205

Leu Ile Leu Lys Tyr Leu

210

<210>119

<211>876

<212>PRT

<213>智人(Homo sapiens)

<400>119

Met Ser Gln Ser Pro Ala Phe Gly Pro Arg Arg Gly Ser Ser Pro Arg

1 5 10 15

Gly Ala Ala Gly Ala Ala Ala Arg Arg Asn Glu Ser Gln Asp Tyr Leu

20 25 30

Leu Met Asp Ser Glu Leu Gly Glu Asp Gly Cys Pro Gln Ala Pro Leu

35 40 45

Pro Cys Tyr Gly Tyr Tyr Pro Cys Phe Arg Gly Ser Asp Asn Arg Leu

50 55 60

Ala His Arg Arg Gln Thr Val Leu Arg Glu Lys Gly Arg Arg Leu Ala

65 70 75 80

Asn Arg Gly Pro Ala Tyr Met Phe Ser Asp Arg Ser Thr Ser Leu Ser

85 90 95

Ile Glu Glu Glu Arg Phe Leu Asp Ala Ala Glu Tyr Gly Asn Ile Pro

100 105 110

Val Val Arg Lys Met Leu Glu Glu Cys His Ser Leu Asn Val Asn Cys

115 120 125

Val Asp Tyr Met Gly Gln Asn Ala Leu Gln Leu Ala Val Ala Asn Glu

130 135 140

His Leu Glu Ile Thr Glu Leu Leu Leu Lys Lys Glu Asn Leu Ser Arg

145 150 155 160

Val Gly Asp Ala Leu Leu Leu Ala Ile Ser Lys Gly Tyr Val Arg Ile

165 170 175

Val Glu Ala Ile Leu Ser His Pro Ala Phe Ala Glu Gly Lys Arg Leu

180 185 190

Ala Thr Ser Pro Ser Gln Ser Glu Leu Gln Gln Asp Asp Phe Tyr Ala

195 200 205

Tyr Asp Glu Asp Gly Thr Arg Phe Ser His Asp Val Thr Pro Ile Ile

210 215 220

Leu Ala Ala His Cys Gln Glu Tyr Glu Ile Val His Thr Leu Leu Arg

225 230 235 240

Lys Gly Ala Arg Ile Glu Arg Pro His Asp Tyr Phe Cys Lys Cys Asn

245 250 255

Asp Cys Asn Gln Lys Gln Lys His Asp Ser Phe Ser His Ser Arg Ser

260 265 270

Arg Ile Asn Ala Tyr Lys Gly Leu Ala Ser Pro Ala Tyr Leu Ser Leu

275 280 285

Ser Ser Glu Asp Pro Val Met Thr Ala Leu Glu Leu Ser Asn Glu Leu

290 295 300

Ala Val Leu Ala Asn Ile Glu Lys Glu Phe Lys Asn Asp Tyr Lys Lys

305 310 315 320

Leu Ser Met Gln Cys Lys Asp Phe Val Val Gly Leu Leu Asp Leu Arg

325 330 335

Arg Asn Thr Glu Glu Val Glu Ala Ile Leu Asn Gly Asp Val Glu Thr

340 345 350

Leu Gln Ser Gly Asp His Gly Arg Pro Asn Leu Ser Arg Leu Lys Leu

355 360 365

Ala Ile Lys Tyr Glu Val Lys Lys Met Gly Lys Ile Met Arg Gly Pro

370 375 380

Phe Met Lys Phe Val Ala His Ala Ala Ser Phe Thr Ile Phe Leu Gly

385 390 395 400

Leu Leu Val Met Asn Ala Ala Asp Arg Phe Glu Gly Thr Lys Leu Leu

405 410 415

Pro Asn Glu Thr Ser Thr Asp Asn Ala Lys Gln Leu Phe Arg Met Lys

420 425 430

Thr Ser Cys Phe Ser Trp Met Glu Met Leu Ile Ile Ser Trp Val Ile

435 440 445

Gly Met Ile Trp Ala Glu Cys Lys Glu Ile Trp Thr Gln Gly Pro Lys

450 455 460

Glu Tyr Leu Phe Glu Leu Trp Asn Met Leu Asp Phe Gly Met Leu Ala

465 470 475 480

Ile Phe Ala Ala Ser Phe Ile Ala Arg Phe Met Ala Phe Trp His Ala

485 490 495

Ser Lys Ala Gln Ser Ile Ile Asp Ala ASn Asp Thr Leu Lys Asp Leu

500 505 510

Thr Lys Val Thr Leu Gly Asp Asn Val Lys Tyr Tyr Asn Leu Ala Arg

515 520 525

Ile Lys Trp Asp Pro Ser Asp Pro Gln Ile Ile Ser Glu Gly Leu Tyr

530 535 540

Ala Ile Ala Val Val Leu Ser Phe Ser Arg Ile Ala Tyr Thr Leu Pro

545 550 555 560

Ala Asn Glu Ser Phe Gly Pro Leu Gln Ile Ser Leu Gly Arg Thr Val

565 570 575

Lys Asp Ile Phe Lys Phe Met Val Ile Phe Ile Met Val Phe Val Ala

580 585 590

Phe Met Ile Gly Met Phe Asn Leu Tyr Ser Tyr Tyr Ile Gly Ala Lys

595 600 605

Gln Asn Glu Ala Phe Thr Thr Val Glu Glu Ser Phe Lys Thr Leu Phe

610 615 620

Trp Ala Ile Phe Gly Leu Ser Glu Val Lys Ser Val Val Ile Asn Tyr

625 630 635 640

Asn His Lys Phe Ile Glu Asn Ile Gly Tyr Val Leu Tyr Gly Val Tyr

645 650 655

Asn Val Thr Met Val Ile Val Leu Leu Asn Met Leu Ile Ala Met Ile

660 665 670

Asn Ser Ser Phe Gln Glu Ile Glu Asp Asp Ala Asp Val Glu Trp Lys

675 680 685

Phe Ala Arg Ala Lys Leu Trp Phe Ser Tyr Phe Glu Glu Gly Arg Thr

690 695 700

Leu Pro Val Pro Phe Asn Leu Val Pro Ser Pro Lys Ser Leu Phe Tyr

705 710 715 720

Leu Leu Leu Lys Leu Lys Lys Trp Ile Ser Glu Leu Phe Gln Gly His

725 730 735

Lys Lys Gly Phe Gln Glu Asp Ala Glu Met Asn Lys Ile Asn Glu Glu

740 745 750

Lys Lys Leu Gly Ile Leu Gly Ser His Glu Asp Leu Ser Lys Leu Ser

755 760 765

Leu Asp Lys Lys Gln Val Gly His Asn Lys Gln Pro Ser Ile Arg Ser

770 775 780

Ser Glu Asp Phe His Leu Asn Ser Phe Asn Asn Pro Pro Arg Gln Tyr

785 790 795 800

Gln Lys Ile Met Lys Arg Leu Ile Lys Arg Tyr Val Leu Gln Ala Gln

805 810 815

Ile Asp Lys Glu Ser Asp Glu Val Asn Glu Gly Glu Leu Lys Glu Ile

820 825 830

Lys Gln Asp Ile Ser Ser Leu Arg Tyr Glu Leu Leu Glu Glu Lys Ser

835 840 845

Gln Asn Thr Glu Asp Leu Ala Glu Leu Ile Arg Glu Leu Gly Glu Lys

850 855 860

Leu Ser Met Glu Pro Asn Gln Glu Glu Thr Asn Arg

865 870 875

<210>120

<211>862

<212>PRT

<213>智人(Homo sapiens)

<400>120

Met Leu Arg Asn Ser Thr Phe Lys Asn Met Gln Arg Arg His Thr Thr

1 5 10 15

Leu Arg Glu Lys Gly Arg Arg Gln Ala Ile Arg Gly Pro Ala Tyr Met

20 25 30

Phe Asn Glu Lys Gly Thr Ser Leu Thr Pro Glu Glu Glu Arg Phe Leu

35 40 45

Asp Ser Ala Glu Tyr Gly Asn Ile Pro Val Val Arg Lys Met Leu Glu

50 55 60

Glu Ser Lys Thr Leu Asn Phe Asn Cys Val Asp Tyr Met Gly Gln Asn

65 70 75 80

Ala Leu Gln Leu Ala Val Gly Asn Glu His Leu Glu Val Thr Glu Leu

85 90 95

Leu Leu Lys Lys Glu Asn Leu Ala Arg Val Gly Asp Ala Leu Leu Leu

100 105 110

Ala Ile Ser Lys Gly Tyr Val Arg Ile Val Glu Ala Ile Leu Asn His

115 120 125

Pro Ala Phe Ala Gln Gly Gln Arg Leu Thr Leu Ser Pro Leu Glu Gln

130 135 140

Glu Leu Arg Asp Asp Asp Phe Tyr Ala Tyr Asp Glu Asp Gly Thr Arg

145 150 155 160

Phe Ser His Asp Ile Thr Pro Ile Ile Leu Ala Ala His Cys Gln Glu

165 170 175

Tyr Glu Ile Val His Ile Leu Leu Leu Lys Gly Ala Arg Ile Glu Arg

180 185 190

Pro His Asp Tyr Phe Cys Lys Cys Asn Glu Cys Thr Glu Lys Gln Arg

195 200 205

Lys Asp Ser Phe Ser His Ser Arg Ser Arg Met Asn Ala Tyr Lys Gly

210 215 220

Leu Ala Ser Ala Ala Tyr Leu Ser Leu Ser Ser Glu Asp Pro Val Leu

225 230 235 240

Thr Ala Leu Glu Leu Ser Asn Glu Leu Ala Arg Leu Ala Asn Ile Glu

245 250 255

Thr Glu Phe Lys Asn Asp Tyr Arg Lys Leu Ser Met Gln Cys Lys Asp

260 265 270

Phe Val Val Gly Val Leu Asp Leu Cys Arg Asp Thr Glu Glu Val Glu

275 280 285

Ala Ile Leu Asn Gly Asp Val Asn Phe Gln Val Trp Ser Asp His His

290 295 300

Arg Pro Ser Leu Ser Arg Ile Lys Leu Ala Ile Lys Tyr Glu Val Lys

305 310 315 320

Lys Phe Val Ala His Pro Asn Cys Gln Gln Gln Leu Leu Thr Met Trp

325 330 335

Tyr Glu Asn Leu Ser Gly Leu Arg Gln Gln Ser Ile Ala Val Lys Phe

340 345 350

Leu Ala Val Phe Gly Val Ser Ile Gly Leu Pro Phe Leu Ala Ile Ala

355 360 365

Tyr Trp Ile Ala Pro Cys Ser Lys Leu Gly Arg Thr Leu Arg Ser Pro

370 375 380

Phe Met Lys Phe Val Ala His Ala Val Ser Phe Thr Ile Phe Leu Gly

385 390 395 400

Leu Leu Val Val Asn Ala Ser Asp Arg Phe Glu Gly Val Lys Thr Leu

405 410 415

Pro Asn Glu Thr Phe Thr Asp Tyr Pro Lys Gln Ile Phe Arg Val Lys

420 425 430

Thr Thr Gln Phe Ser Trp Thr Glu Met Leu Ile Met Lys Trp Val Leu

435 440 445

Gly Met Ile Trp Ser Glu Cys Lys Glu Ile Trp Glu Glu Gly Pro Arg

450 455 460

Glu Tyr Val Leu His Leu Trp Asn Leu Leu Asp Phe Gly Met Leu Ser

465 470 475 480

Ile Phe Val Ala Ser Phe Thr Ala Arg Phe Met Ala Phe Leu Lys Ala

485 490 495

Thr Glu Ala Gln Leu Tyr Val Asp Gln His Val Gln Asp Asp Thr Leu

500 505 510

His Asn Val Ser Leu Pro Pro Glu Val Ala Tyr Phe Thr Tyr Ala Arg

515 520 525

Asp Lys Trp Trp Pro Ser Asp Pro Gln Ile Ile Ser Glu Gly Leu Tyr

530 535 540

Ala Ile Ala Val Val Leu Ser Phe Ser Arg Ile Ala Tyr Ile Leu Pro

545 550 555 560

Ala Asn Glu Ser Phe Gly Pro Leu Gln Ile Ser Leu Gly Arg Thr Val

565 570 575

Lys Asp Ile Phe Lys Phe Met Val Ile Phe Ile Met Val Phe Val Ala

580 585 590

Phe Met Ile Gly Met Phe Asn Leu Tyr Ser Tyr Tyr Arg Gly Ala Lys

595 600 605

Tyr Asn Pro Ala Phe Thr Thr Val Glu Glu Ser Phe Lys Thr Leu Phe

610 615 620

Trp Ser Ile Phe Gly Leu Ser Glu Val Ile Ser Val Val Leu Lys Tyr

625 630 635 640

Asp His Lys Phe Ile Glu Asn Ile Gly Tyr Val Leu Tyr Gly Val Tyr

645 650 655

Asn Val Thr Met Val Val Val Leu Leu Asn Met Leu Ile Ala Met Ile

660 665 670

Asn Asn Ser Tyr Gln Glu Ile Glu Glu Asp Ala Asp Val Glu Trp Lys

675 680 685

Phe Ala Arg Ala Lys Leu Trp Leu Ser Tyr Phs Asp Glu Gly Arg Thr

690 695 700

Leu Pro Ala Pro Phe Asn Leu Val Pro Ser Pro Lys Ser Phe Tyr Tyr

705 710 715 720

Leu Ile Met Arg Ile Lys Met Cys Leu Ile Lys Leu Cys Lys Ser Lys

725 730 735

Ala Lys Ser Cys Glu Asn Asp Leu Glu Met Gly Met Leu Asn Ser Lys

740 745 750

Phe Lys Lys Thr Arg Tyr Gln Ala Gly Met Arg Asn Ser Glu Asn Leu

755 760 765

Thr Ala Asn Asn Thr Leu Ser Lys Pro Thr Arg Tyr Gln Lys Ile Met

770 775 780

Lys Arg Leu Ile Lys Arg Tyr Val Leu Lys Ala Gln Val Asp Arg Glu

785 790 795 800

Asn Asp Glu Val Asn Glu Gly Glu Leu Lys Glu Ile Lys Gln Asp Ile

805 810 815

Ser Ser Leu Arg Tyr Glu Leu Leu Glu Glu Lys Ser Gln Ala Thr Gly

820 825 830

Glu Leu Ala Asp Leu Ile Gln Gln Leu Ser Glu Lys Phe Gly Lys Asn

835 840 845

Leu Asn Lys Asp His Leu Arg Val Asn Lys Gly Lys Asp Ile

850 855 860

<210>121

<211>893

<212>PRT

<213>豚鼠(Cavia porcellus)

<400>121

Met Asp Asp Gly Cys Pro Gln Leu Pro Leu Pro Pro His Gly Tyr Tyr

1 5 10 15

Pro Ser Leu Arg Gly Thr Asp Asn Arg Leu Thr His Arg Arg Gln Thr

20 25 30

Val Leu Arg Glu Lys Gly Arg Arg Leu Ala Asn Arg Gly Pro Ala Tyr

35 40 45

Met Phe Asn Asp His Ser Thr Thr Leu Ser Ile Glu Glu Glu Arg Phe

50 55 60

Leu Asp Ala Ala Glu Tyr Gly Asn Ile Pro Val Val Arg Lys Met Leu

65 70 75 80

Glu Glu Cys Leu Ser Leu Asn Val Asn Cys Val Asp Tyr Met Gly Gln

85 90 95

Asn Ala Leu Gln Leu Ala Val Ala Asn Glu His Leu Glu Ile Thr Glu

100 105 110

Leu Leu Leu Lys Lys Glu Asn Leu Ser Arg Val Gly Asp Ala Leu Leu

115 120 125

Leu Ala Ile Ser Lys Gly Tyr Val Arg Ile Val Glu Ala Ile Leu Ser

130 135 140

His Pro Ala Phe Ala Glu Gly Lys Arg Leu Ala Thr Ser Pro Ser Gln

145 150 155 160

Ser Glu Leu Gln Gln Asp Asp Phe Tyr Ala Tyr Asp Glu Asp Gly Thr

165 170 175

Arg Phe Ser His Asp Val Thr Pro Ile Ile Leu Ala Ala His Cys Gln

180 185 190

Glu Tyr Glu Ile Val His Thr Leu Leu Arg Lys Gly Ala Arg Ile Glu

195 200 205

Arg Pro His Asp Tyr Phe Cys Lys Cys Ser Glu Cys Asn Gln Lys Gln

210 215 220

Lys His Asp Ser Phe Ser His Ser Arg Ser Arg Ile Asn Ala Tyr Lys

225 230 235 240

Gly Leu Ala Ser Pro Ala Tyr Leu Ser Leu Ser Ser Glu Asp Pro Val

245 250 255

Met Thr Ala Leu Glu Leu Ser Asn Glu Leu Ala Val Leu Ala Asn Ile

260 265 270

Glu Lys Glu Phe Lys Asn Asp Tyr Lys Lys Leu Ser Met Gln Cys Lys

275 280 285

Asp Phe Val Val Gly Leu Leu Asp Leu Cys Arg Asn Thr Glu Glu Val

290 295 300

Glu Ala Ile Leu Asn Gly Asp Val Glu Thr Cys Gln Ser Gly Asp Gln

305 310 315 320

Gly Arg Pro Asn Leu Ser Arg Leu Lys Leu Ala Ile Lys Tyr Glu Val

325 330 335

Lys Lys Phe Val Ala His Pro Asn Cys Gln Gln Gln Leu Leu Ser Ile

340 345 350

Trp Tyr Glu Asn Leu Ser Gly Leu Arg Gln Gln Thr Met Ala Val Lys

355 360 365

Phe Leu Val Val Leu Gly Val Ala Ile Gly Leu Pro Phe Leu Ala Leu

370 375 380

Ile Tyr Trp Cys Ala Pro Cys Ser Lys Met Gly Lys Ile Met Arg Gly

385 390 395 400

Pro Phe Met Lys Phe Val Ala His Ala Ala Ser Phe Thr Ile Phe Leu

405 410 415

Gly Leu Leu Val Met Asn Ala Ala Asp Arg Phe Glu Gly Thr Lys Leu

420 425 430

Arg Pro Asn Glu Thr Ser Thr Asp Asn Ala Lys Gln Leu Phe Arg Met

435 440 445

Lys Thr Ser Cys Phe Ser Trp Met Glu Met Leu Ile Ile Ser Trp Val

450 455 460

Ile Gly Met Ile Trp Ala Glu Cys Lys Glu Ile Trp Ala Gln Gly Pro

465 470 475 480

Lys Glu Tyr Leu Phe Glu Leu Trp Asn Met Leu Asp Phe Gly Met Leu

485 490 495

Ala Ile Phe Ala Ala Ser Phe Ile Ala Arg Phe Met Ala Phe Trp His

500 505 510

Ala Ser Lys Ala Gln Ser Ile Ile Asp Ala Asn Asp Thr Leu Lys Asp

515 520 525

Leu Thr Lys Val Thr Leu Gly Glu Asp Val Lys Tyr Tyr Asn Leu Ala

530 535 540

Arg Ile Lys Trp Asp Pro Ser Asp Pro Gln Ile Ile Ser Glu Gly Leu

545 550 555 560

Tyr Ala Ile Ala Val Val Leu Ser Phe Ser Arg Ile Ala Tyr Ile Leu

565 570 575

Pro Ala Asn Glu Ser Phe Gly Pro Leu Gln Ile Ser Leu Gly Arg Thr

580 585 590

Val Lys Asp Ile Phe Lys Phe Met Val Ile Phe Ile Met Val Phe Val

595 600 605

Ala Phe Met Ile Gly Met Phe Asn Leu Tyr Ser Tyr Tyr Ile Gly Ala

610 615 620

Lys Gln Asn Glu Ala Phe Thr Thr Val Glu Glu Ser Phe Lys Thr Leu

625 630 635 640

Phe Trp Ala Ile Phe Gly Leu Ser Glu Val Lys Ser Val Val Ile Asn

645 650 655

Tyr Asn His Lys Phe Ile Glu Asn Ile Gly Tyr Val Leu Tyr Gly Val

660 665 670

Tyr Asn Val Thr Met Val Ile Val Leu Leu Asn Met Leu Ile Ala Met

675 680 685

Ile Asn Ser Ser Phe Gln Glu Ile Glu Asp Asp Ala Asp Val Glu Trp

690 695 700

Lys Phe Ala Arg Ala Lys Leu Trp Phe Ser Tyr Phe Glu Glu Gly Arg

705 710 715 720

Thr Leu Pro Val Pro Phe Asn Leu Val Pro Ser Pro Lys Ser Leu Leu

725 730 735

Tyr Leu Leu Leu Lys Phe Lys Lys Trp Gly Phe Glu Leu Phe Gln Gly

740 745 750

His Lys Lys Ala Phe Gln Glu Asp Ala Glu Met Asn Lys Arg Asn Glu

755 760 765

Glu Lys Lys Phe Gly Ile Leu Gly Ser His Glu Asp Leu Ser Lys Leu

770 775 780

Ser Val Asp Lys Lys Gln Leu Gly Gln Asn Lys Gln Ser Ser Ile Arg

785 790 795 800

Ser Ser Glu Asp Phe His Leu Asn Ser Phe Asn Asn Pro Pro Arg Gln

805 810 815

Tyr Gln Lys Ile Met Lys Arg Leu Ile Lys Arg Tyr Val Leu Gln Ala

820 825 830

Gln Ile Asp Lys Glu Ser Asp Glu Val Asn Glu Gly Glu Leu Lys Glu

835 840 845

Ile Lys Gln Asp Ile Ser Ser Leu Arg Tyr Glu Leu Leu Glu Glu Lys

850 855 860

Ser Gln Asn Thr Glu Asp Leu Ala Glu Leu Ile Arg Lys Leu Gly Glu

865 870 875 880

Lys Leu Ser Ser Glu Pro Lys Gln Glu Glu Ile Asn Arg

885 890

<210>122

<211>597

<212>PRT

<213>豚鼠(Cavia porcellus)

<400>122

Met Phe Asn Asp His Ser Thr Thr Leu Ser Ile Glu Glu Glu Arg Phe

1 5 10 15

Leu Asp Ala Ala Glu Tyr Gly Asn Ile Pro Val Val Arg Lys Met Leu

20 25 30

Glu Glu Cys Leu Ser Leu Asn Val Asn Cys Val Asp Tyr Met Gly Gln

35 40 45

Asn Ala Leu Gln Leu Ala Val Ala Asn Glu His Leu Glu Ile Thr Glu

50 55 60

Leu Leu Leu Lys Lys Glu Asn Leu Ser Arg Val Gly Asp Ala Leu Leu

65 70 75 80

Leu Ala Ile Ser Lys Gly Tyr Val Arg Ile Val Glu Ala Ile Leu Ser

85 90 95

His Pro Ala Phe Ala Glu Gly Lys Arg Leu Ala Thr Ser Leu Ser Gln

100 105 110

Ser Glu Leu Gln Gln Asp Asp Phe Tyr Ala Tyr Asp Glu Asp Gly Thr

115 120 125

Arg Phe Ser His Asp Val Thr Pro Ile Ile Leu Ala Ala His Cys Gln

130 135 140

Glu Tyr Glu Ile Val His Thr Leu Leu Arg Lys Gly Ala Arg Ile Glu

145 150 155 160

Arg Pro His Asp Tyr Phe Cys Lys Cys Ser Glu Cys Asn Gln Lys Gln

165 170 175

Lys His Asp Ser Phe Ser His Ser Arg Ser Arg Ile Asn Ala Tyr Lys

180 185 190

Gly Leu Ala Ser Pro Ala Tyr Leu Ser Leu Ser Ser Glu Asp Pro Val

195 200 205

Met Thr Ala Leu Glu Leu Ser Asn Glu Leu Ala Val Leu Ala Asn Ile

210 215 220

Glu Lys Glu Phe Lys Asn Asp Tyr Lys Lys Leu Ser Met Gln Cys Lys

225 230 235 240

Asp Phe Val Val Gly Leu Leu Asp Leu Cys Arg Asn Thr Glu Glu Val

245 250 255

Glu Ala Ile Leu Asn Gly Asp Ile Glu Thr Cys Gln Pro Gly Asp Gln

260 265 270

Gly Arg Pro Asn Leu Ser Arg Leu Lys Leu Ala Ile Lys Tyr Glu Val

275 280 285

Lys Lys Phe Val Ala His Pro Asn Cys Gln Gln Gln Leu Leu Ser Ile

290 295 300

Trp Tyr Glu Asn Leu Ser Gly Leu Arg Gln Gln Thr Met Ala Val Lys

305 310 315 320

Phe Leu Val Val Leu Gly Val Ala Ile Gly Leu Pro Phe Leu Ala Leu

325 330 335

Ile Tyr Trp Cys Ala Pro Cys Ser Lys Met Gly Lys Ile Met Arg Gly

340 345 350

Pro Phe Met Lys Phe Val Ala His Ala Ala Ser Phe Thr Ile Phe Leu

355 360 365

Gly Leu Leu Val Met Asn Ala Ala Asp Arg Phe Glu Gly Thr Lys Leu

370 375 380

Arg Pro Asn Glu Thr Ser Thr Asp Asn Ala Lys Gln Leu Phe Arg Met

385 390 395 400

Lys Thr Ser Cys Phe Ser Trp Met Glu Met Leu Ile Ile Ser Trp Val

405 410 415

Ile Gly Met Val Trp Ala Glu Cys Lys Glu Ile Trp Ala Gln Gly Pro

420 425 430

Lys Glu Tyr Leu Phe Glu Leu Trp Asn Met Leu Asp Phe Gly Met Leu

435 440 445

Ala Ile Phe Ala Ala Ser Phe Ile Ala Arg Phe Met Ala Phe Trp His

450 455 460

Ala Ser Lys Ala Gln Ser Ile Ile Asp Ala Asn Asp Thr Leu Lys Asp

465 470 475 480

Leu Thr Lys Val Thr Leu Gly Glu Asp Val Lys Tyr Tyr Asn Leu Ala

485 490 495

Arg Ile Lys Trp Asp Pro Ser Asp Pro Gln Ile Ile Ser Glu Gly Leu

500 505 510

Tyr Ala Ile Ala Val Val Leu Ser Phe Ser Arg Ile Ala Tyr Ile Leu

515 520 525

Pro Ala Asn Glu Ser Phe Gly Pro Leu Gln Ile Ser Leu Gly Arg Thr

530 535 540

Val Lys Asp Ile Phe Lys Phe Met Val Ile Phe Ile Met Val Phe Val

545 550 555 560

Ala Phe Met Ile Gly Met Phe Asn Leu Tyr Ser His Tyr Ile Gly Ala

565 570 575

Lys Gln Asn Glu Ala Phe Thr Thr Tyr Val Ile Ser Asp Val Leu Thr

580 585 590

Met Glu Ile Ala Asp

595

<210>123

<211>815

<212>PRT

<213>豚鼠(Cavia porcellus)

<400>123

Met Asp Asp Gly Cys Pro Gln Leu Pro Leu Pro Pro His Gly Tyr Tyr

1 5 10 15

Pro Ser Leu Arg Gly Thr Asp Asn Arg Leu Thr His Arg Arg Gln Thr

20 25 30

Val Leu Arg Glu Lys Gly Arg Arg Leu Ala Asn Arg Gly Pro Ala Tyr

35 40 45

Met Phe Asn Asp His Ser Thr Thr Leu Ser Ile Glu Glu Glu Arg Phe

50 55 60

Leu Asp Ala Ala Glu Tyr Gly Asn Ile Pro Val Val Arg Lys Met Leu

65 70 75 80

Glu Glu Cys Leu Ser Leu Asn Val Asn Cys Val Asp Tyr Met Gly Gln

85 90 95

Asn Ala Leu Gln Leu Ala Val Ala Asn Glu His Leu Glu Ile Thr Glu

100 105 110

Leu Leu Leu Lys Lys Glu Asn Leu Ser Arg Val Gly Asp Ala Leu Leu

115 120 125

Leu Ala Ile Ser Lys Gly Tyr Val Arg Ile Val Glu Ala Ile Leu Ser

130 135 140

His Pro Ala Phe Ala Glu Gly Lys Arg Leu Ala Thr Ser Pro Ser Gln

145 150 155 160

Ser Glu Leu Gln Gln Asp Asp Phe Tyr Ala Tyr Asp Glu Asp Gly Thr

165 170 175

Arg Phe Ser His Asp Val Thr Pro Ile Ile Leu Ala Ala His Cys Gln

180 185 190

Glu Tyr Glu Ile Val His Thr Leu Leu Arg Lys Gly Ala Arg Ile Glu

195 200 205

Arg Pro His Asp Tyr Phe Cys Glu Cys Ser Glu Cys Asn Gln Lys Gln

210 215 220

Lys His Asp Ser Phe Ser His Ser Arg Ser Arg Ile Asn Ala Tyr Lys

225 230 235 240

Gly Leu Ala Ser Pro Ala Tyr Leu Ser Leu Ser Ser Glu Asp Pro Val

245 250 255

Met Thr Ala Leu Glu Leu Ser Asn Glu Leu Ala Val Leu Ala Asn Ile

260 265 270

Glu Lys Glu Phe Lys Asn Asp Tyr Lys Lys Leu Ser Met Gln Cys Lys

275 280 285

Asp Phe Val Val Gly Leu Leu Asp Leu Cys Arg Asn Thr Glu Glu Val

290 295 300

Glu Ala Ile Leu Asn Gly Asp Val Glu Thr Cys Gln Pro Gly Asp Gln

305 310 315 320

Gly Arg Pro Asn Leu Ser Arg Leu Lys Leu Ala Ile Lys Tyr Glu Val

325 330 335

Lys Lys Phe Val Ala His Pro Asn Cys Gln Gln Gln Leu Leu Ser Ile

340 345 350

Trp Tyr Glu Asn Leu Ser Gly Leu Arg Gln Gln Thr Met Ala Val Lys

355 360 365

Phe Leu Val Val Leu Gly Val Ala Ile Gly Leu Pro Phe Leu Ala Leu

370 375 380

Ile Tyr Trp Cys Ala Pro Cys Ser Lys Met Gly Lys Ile Met Arg Gly

385 390 395 400

Pro Phe Met Lys Phe Val Ala His Ala Ala Ser Phe Thr Ile Phe Leu

405 410 415

Gly Leu Leu Val Met Asn Ala Ala Asp Arg Phe Glu Gly Thr Lys Leu

420 425 430

Arg Pro Asn Glu Thr Ser Thr Asp Asn Ala Lys Gln Leu Phe Arg Met

435 440 445

Lys Thr Ser Cys Phe Ser Trp Met Glu Met Leu Ile Ile Ser Trp Val

450 455 460

Ile Ala Arg Ile Lys Trp Asp Pro Ser Asp Pro Gln Ile Ile Ser Glu

465 470 475 480

Gly Leu Tyr Ala Ile Ala Val Val Leu Ser Phe Ser Arg Ile Ala Tyr

485 490 495

Ile Leu Pro Ala Asn Glu Ser Phe Gly Pro Leu Gln Ile Ser Leu Gly

500 505 510

Arg Thr Val Lys Asp Ile Phe Lys Phe Met Val Ile Phe Ile Met Val

515 520 525

Phe Val Ala Phe Met Ile Gly Met Phe His Leu Tyr Ser Tyr Tyr Ile

530 535 540

Gly Ala Lys Gln Asn Glu Ala Phe Thr Thr Val Glu Glu Ser Phe Lys

545 550 555 560

Thr Leu Phe Trp Ala Ile Phe Gly Leu Ser Glu Val Lys Ser Val Val

565 570 575

Ile Asn Tyr Asn His Lys Phe Ile Glu Asn Ile Gly Tyr Val Leu Tyr

580 585 590

Gly Val Tyr Asn Val Thr Met Val Ile Val Leu Leu Asn Met Leu Ile

595 600 605

Ala Met Ile Asn Ser Ser Phe Gln Glu Ile Glu Asp Asp Ala Asp Val

610 615 620

Glu Trp Lys Phe Ala Arg Ala Lys Leu Trp Phe Ser Tyr Phe Glu Glu

625 630 635 640

Gly Arg Thr Leu Pro Val Pro Phe Asn Leu Val Pro Ser Pro Lys Ser

645 650 655

Leu Leu Tyr Leu Leu Leu Lys Phe Lys Lys Trp Gly Phe Glu Leu Phe

660 665 670

Gln Gly His Lys Lys Ala Phe Gln Glu Asp Ala Glu Met Asn Lys Arg

675 680 685

Asn Glu Glu Lys Lys Phe Gly Ile Leu Gly Ser His Glu Asp Leu Ser

690 695 700

Lys Leu Ser Val Asp Lys Lys Gln Leu Gly Gln Asn Lys Gln Ser Ser

705 710 715 720

Ile Arg Ser Ser Glu Asp Phe His Leu Asn Ser Phe Asn Asn Pro Pro

725 730 735

Arg Gln Tyr Gln Lys Ile Met Lys Arg Leu Ile Lys Arg Tyr Val Leu

740 745 750

Gln Ala Gln Ile Asp Lys Glu Ser Asp Glu Val Asn Glu Gly Glu Leu

755 760 765

Lys Glu Ile Lys Gln Asp Ile Ser Ser Leu Arg Tyr Glu Leu Leu Glu

770 775 780

Glu Lys Ser Gln Asn Thr Glu Asp Leu Ala Glu Leu Ile Arg Lys Leu

785 790 795 800

Gly Glu Lys Leu Ser Ser Glu Pro Lys Gln Glu Glu Ile Asn Arg

805 810 815

<210>124

<211>876

<212>PRT

<213>智人(Homo sapiens)

<400>124

Met Ser Gln Ser Pro Ala Phe Gly Pro Arg Arg Gly Ser Ser Pro Arg

1 5 10 15

Gly Ala Ala Gly Ala Ala Ala Arg Arg Asn Glu Ser Gln Asp Tyr Leu

20 25 30

Leu Met Asp Ser Glu Leu Gly Glu Asp Gly Cys Pro Gln Ala Pro Leu

35 40 45

Pro Cys Tyr Gly Tyr Tyr Pro Cys Phe Arg Gly Ser Asp Asn Arg Leu

50 55 60

Ala His Arg Arg Gln Thr Val Leu Arg Glu Lys Gly Arg Arg Leu Ala

65 70 75 80

Asn Arg Gly Pro Ala Tyr Met Phe Ser Asp Arg Ser Thr Ser Leu Ser

85 90 95

Ile Glu Glu Glu Arg Phe Leu Asp Ala Ala Glu Tyr Gly Asn Ile Pro

100 105 110

Val Val Arg Lys Met Leu Glu Glu Cys His Ser Leu Asn Val Asn Cys

115 120 125

Val Asp Tyr Met Gly Gln Asn Ala Leu Gln Leu Ala Val Ala Asn Glu

130 135 140

His Leu Glu Ile Thr Glu Leu Leu Leu Lys Lys Glu Asn Leu Ser Arg

145 150 155 160

Val Gly Asp Ala Leu Leu Leu Ala Ile Ser Lys Gly Tyr Val Arg Ile

165 170 175

Val Glu Ala Ile Leu Ser His Pro Ala Phe Ala Glu Gly Lys Arg Leu

180 185 190

Ala Thr Ser Pro Ser Gln Ser Glu Leu Gln Gln Asp Asp Phe Tyr Ala

195 200 205

Tyr Asp Glu Asp Gly Thr Arg Phe Ser His Asp Val Thr Pro Ile Ile

210 215 220

Leu Ala Ala His Cys Gln Glu Tyr Glu Ile Val His Thr Leu Leu Arg

225 230 235 240

Lys Gly Ala Arg Ile Glu Arg Pro His Asp Tyr Phe Cys Lys Cys Asn

245 250 255

Asp Cys Asn Gln Lys Gln Lys His Asp Ser Phe Ser His Ser Arg Ser

260 265 270

Arg Ile Asn Ala Tyr Lys Gly Leu Ala Ser Pro Ala Tyr Leu Ser Leu

275 280 285

Ser Ser Glu Asp Pro Val Met Thr Ala Leu Glu Leu Ser Asn Glu Leu

290 295 300

Ala Val Leu Ala Asn Ile Glu Lys Glu Phe Lys Asn Asp Tyr Lys Lys

305 310 315 320

Leu Ser Met Gln Cys Lys Asp Phe Val Val Gly Leu Leu Asp Leu Arg

325 330 335

Arg Asn Thr Glu Glu Val Glu Ala Ile Leu Asn Gly Asp Val Glu Thr

340 345 350

Leu Gln Ser Gly Asp His Gly Arg Pro Asn Leu Ser Arg Leu Lys Leu

355 360 365

Ala Ile Lys Tyr Glu Val Lys Lys Met Gly Lys Ile Met Arg Gly Pro

370 375 380

Phe Met Lys Phe Val Ala His Ala Ala Ser Phe Thr Ile Phe Leu Gly

385 390 395 400

Leu Leu Val Met Asn Ala Ala Asp Arg Phe Glu Gly Thr Lys Leu Leu

405 410 415

Pro Asn Glu Thr Ser Thr Asp Asn Ala Lys Gln Leu Phe Arg Met Lys

420 425 430

Thr Ser Cys Phe Ser Trp Met Glu Met Leu Ile Ile Ser Trp Val Ile

435 440 445

Gly Met Ile Trp Ala Glu Cys Lys Glu Ile Trp Thr Gln Gly Pro Lys

450 455 460

Glu Tyr Leu Phe Glu Leu Trp Asn Met Leu Asp Phe Gly Met Leu Ala

465 470 475 480

Ile Phe Ala Ala Ser Phe Ile Ala Arg Phe Met Ala Phe Trp His Ala

485 490 495

Ser Lys Ala Gln Ser Ile Ile Asp Ala Asn Asp Thr Leu Lys Asp Leu

500 505 510

Thr Lys Val Thr Leu Gly Asp Asn Val Lys Tyr Tyr Asn Leu Ala Arg

515 520 525

Ile Lys Trp Asp Pro Ser Asp Pro Gln Ile Ile Ser Glu Gly Leu Tyr

530 535 540

Ala Ile Ala Val Val Leu Ser Phe Ser Arg Ile Ala Tyr Thr Leu Pro

545 550 555 560

Ala Asn Glu Ser Phe Gly Pro Leu Gln Ile Ser Leu Gly Arg Thr Val

565 570 575

Lys Asp Ile Phe Lys Phe Met Val Ile Phe Ile Met Val Phe Val Ala

580 585 590

Phe Met Ile Gly Met Phe Asn Leu Tyr Ser Tyr Tyr Ile Gly Ala Lys

595 600 605

Gln Asn Glu Ala Phe Thr Thr Val Glu Glu Ser Phe Lys Thr Leu Phe

610 615 620

Trp Ala Ile Phe Gly Leu Ser Glu Val Lys Ser Val Val Ile Asn Tyr

625 630 635 640

Asn His Lys Phe Ile Glu Asn Ile Gly Tyr Val Leu Tyr Gly Val Tyr

645 650 655

Asn Val Thr Met Val Ile Val Leu Leu Asn Met Leu Ile Ala Met Ile

660 665 670

Asn Ser Ser Phe Gln Glu Ile Glu Asp Asp Ala Asp Val Glu Trp Lys

675 680 685

Phe Ala Arg Ala Lys Leu Trp Phe Ser Tyr Phe Glu Glu Gly Arg Thr

690 695 700

Leu Pro Val Pro Phe Asn Leu Val Pro Ser Pro Lys Ser Leu Phe Tyr

705 710 715 720

Leu Leu Leu Lys Leu Lys Lys Trp Ile Ser Glu Leu Phe Gln Gly His

725 730 735

Lys Lys Gly Phe Gln Glu Asp Ala Glu Met Asn Lys Ile Asn Glu Glu

740 745 750

Lys Lys Leu Gly Ile Leu Gly Ser His Glu Asp Leu Ser Lys Leu Ser

755 760 765

Leu Asp Lys Lys Gln Val Gly His Asn Lys Gln Pro Ser Ile Arg Ser

770 775 780

Ser Glu Asp Phe His Leu Asn Ser Phe Asn Asn Pro Pro Arg Gln Tyr

785 790 795 800

Gln Lys Ile Met Lys Arg Leu Ile Lys Arg Tyr Val Leu Gln Ala Gln

805 810 815

Ile Asp Lys Glu Ser Asp Glu Val Asn Glu Gly Glu Leu Lys Glu Ile

820 825 830

Lys Gln Asp Ile Ser Ser Leu Arg Tyr Glu Leu Leu Glu Glu Lys Ser

835 840 845

Gln Asn Thr Glu Asp Leu Ala Glu Leu Ile Arg Glu Leu Gly Glu Lys

850 855 860

Leu Ser Met Glu Pro Asn Gln Glu Glu Thr Asn Arg

865 870 875

<210>125

<211>1442

<212>DNA

<213>智人(Homo sapiens)

<220>

<221>CDS

<222>(15)..(1139)

<400>125

tttttttttt tgag atg gag ttt tcg ctc ttg ttg ccc agg ctg gag tgc 50

Met Glu Phe Ser Leu Leu Leu Pro Arg Leu Glu Cys

1 5 10

aat ggc gca atc tca gct cac cgc aac ctc cgc ctc ccg ggt tca agc 98

Asn Gly Ala Ile Ser Ala His Arg Asn Leu Arg Leu Pro Gly Ser Ser

15 20 25

gat tct cct gcc tca gcc tcc cca gta gct ggg att aca ggc atg tgc 146

Asp Ser Pro Ala Ser Ala Ser Pro Val Ala Gly Ile Thr Gly Met Cys

30 35 40

acc cac gct cgg cta att ttg tat ttt ttt tta gta gag atg gag ttt 194

Thr His Ala Arg Leu Ile Leu Tyr Phe Phe Leu Val Glu Met Glu Phe

45 50 55 60

ctc cat gtt ggt cag gct ggt ctc gaa ctc ccg acc tca gat gat ccc 242

Leu His Val Gly Gln Ala Gly Leu Glu Leu Pro Thr Ser Asp Asp Pro

65 70 75

tcc gtc tcg gcc tcc caa agt gct aga tac agg act ggc cac cat gcc 290

Ser Val Ser Ala Ser Gln Ser Ala Arg Tyr Arg Thr Gly His His Ala

80 85 90

cgg ctc tgc ctg gct aat ttt tgt ggt aga aac agg gtt tca ctg atg 338

Arg Leu Cys Leu Ala Asn Phe Cys Gly Arg Asn Arg Val Ser Leu Met

95 100 105

tgc cca agc tgg tct cct gag ctc aag cag tcc acc tgc ctc agc ctc 386

Cys Pro Ser Trp Ser Pro Glu Leu Lys Gln Ser Thr Cys Leu Ser Leu

110 115 120

cca aag tgc tgg gat tac agg cgt gca gcc gtg cct ggc ctt ttt att 434

Pro Lys Cys Trp Asp Tyr Arg Arg Ala Ala Val Pro Gly Leu Phe Ile

125 130 135 140

tta ttt ttt tta aga cac agg tgt ccc act ctt acc cag gat gaa gtg 482

Leu Phe Phe Leu Arg His Arg Cys Pro Thr Leu Thr Gln Asp Glu Val

145 150 155

cag tgg tgt gat cac agc tca ctg cag cct tca act cct gag atc aag 530

Gln Trp Cys Asp His Ser Ser Leu Gln Pro Ser Thr Pro Glu Ile Lys

160 165 170

cat cct cct gcc tca gcc tcc caa gta gct ggg acc aaa gac atg cac 578

His Pro Pro Ala Ser Ala Ser Gln Val Ala Gly Thr Lys Asp Met His

175 180 185

cac tac acc tgg cta att ttt att ttt att ttt aat ttt ttg aga cag 626

His Tyr Thr Trp Leu Ile Phe Ile Phe Ile Phe Asn Phe Leu Arg Gln

190 195 200

agt ctc aac tct gtc acc cag gct gga gtg cag tgg cgc aat ctt ggc 674

Ser Leu Asn Ser Val Thr Gln Ala Gly Val Gln Trp Arg Asn Leu Gly

205 210 215 220

tca ctg caa cct ctg cct ccc ggg ttc aag tta ttc tcc tgc ccc agc 722

Ser Leu Gln Pro Leu Pro Pro Gly Phe Lys Leu Phe Ser Cys Pro Ser

225 230 235

ctc ctg agt agc tgg gac tac agg cgc cca cca cgc cta gct aat ttt 770

Leu Leu Ser Ser Trp Asp Tyr Arg Arg Pro Pro Arg Leu Ala Asn Phe

240 245 250

ttt gta ttt tta gta gag atg ggg ttc acc atg ttc gcc agg ttg atc 818

Phe Val Phe Leu Val Glu Met Gly Phe Thr Met Phe Ala Arg Leu Ile

255 260 265

ttg atc tct gga cct tgt gat ctg cct gcc tcg gcc tcc caa agt gct 866

Leu Ile Ser Gly Pro Cys Asp Leu Pro Ala Ser Ala Ser Gln Ser Ala

270 275 280

ggg att aca ggc gtg agc cac cac gcc cgg ctt att ttt aat ttt tgt 914

Gly Ile Thr Gly Val Ser His His Ala Arg Leu Ile Phe Asn Phe Cys

285 290 295 300

ttg ttt gaa atg gaa tct cac tct gtt acc cag gct gga gtg caa tgg 962

Leu Phe Glu Met Glu Ser His Ser Val Thr Gln Ala Gly Val Gln Trp

305 310 315

cca aat ctc ggc tca ctg caa cct ctg cct ccc ggg ctc aag cga ttc 1010

Pro Asn Leu Gly Ser Leu Gln Pro Leu Pro Pro Gly Leu Lys Arg Phe

320 325 330

tcc tgt ctc agc ctc cca agc agc tgg gat tac ggg cac ctg cca cca 1058

Ser Cys Leu Ser Leu Pro Ser Ser Trp Asp Tyr Gly His Leu Pro Pro

335 340 345

cac ccc gct aat ttt tgt att ttc att aga ggc ggg gtt tca cca tat 1106

His Pro Ala Asn Phe Cys Ile Phe Ile Arg Gly Gly Val Ser Pro Tyr

350 355 360

ttg tca ggc tgg tct caa act cct gac ctc agg tgacccacct gcctcagcct 1159

Leu Ser Gly Trp Ser Gln Thr Pro Asp Leu Arg

365 370 375

tccaaagtgc tgggattaca ggcgtgagcc acctcaccca gccggctaat ttagataaaa 1219

aaatatgtag caatgggggg tcttgctatg ttgcccaggc tggtctcaaa cttctggctt 1279

catgcaatcc ttccaaatga gccacaacac ccagccagtc acatttttta aacagttaca 1339

tctttatttt agtatactag aaagtaatac aataaacatg tcaaacctgc aaattcagta 1399

gtaacagagt tcttttataa cttttaaaca aagctttaga gca 1442

Claims

1.一种选自SEQ ID NO：18、SEQ ID NO：68和SEQ ID NO：120中一种或多种的肽。

2.一种组合物，其特征在于，所述组合物含有一种或多种权利要求1所述的肽及其载体。

3.一种蛋白质，其特征在于，所述蛋白质包括权利要求1所述的肽，所述肽的3′或5′末端侧翼具有1到25个额外的氨基酸修饰。

4.一种蛋白质，其特征在于，所述蛋白质包含权利要求1所述的至少两个肽。

5.一种蛋白质，其特征在于，所述蛋白质包含权利要求1所述的至少两个肽的重复。

6.一种蛋白质，其特征在于，所述蛋白质包含与抗体、抗体片段或抗体样分子融合的权利要求1所述的肽。

7.一种核酸，其特征在于，所述核酸编码与权利要求1所述肽相对应的氨基酸序列。

8.一种组合物，其特征在于，所述组合物包含权利要求7所述的一种或多种核酸以及其药学上可接受的载体。

9.权利要求1、2、7和8任一所述的肽、核酸或组合物在制备用于治疗患者疾病的药物中的应用，所述疾病需要除去或破坏细胞。

10.如权利要求9所述的应用，其特征在于，所述疾病是选自以下组织的良性或恶性肿瘤：即肺、乳房、胃、胰、前列腺、膀胱、骨、卵巢、皮肤、肾、窦、结肠、肠、胃、直肠、食道、心、脾、唾液腺、血液、大脑和其覆盖物、脊髓和其覆盖物、肌肉、结缔组织、肾上腺、副甲状腺、甲状腺、子宫、睾丸、垂体、生殖器、肝脏、胆囊、眼、耳、鼻、喉、扁桃腺、口、淋巴结和淋巴组织。

11.如权利要求9所述的应用，其特征在于，所述疾病是选自以下组织的增生、肥大或过度生长：即肺、乳房、胃、胰、前列腺、膀胱、骨、卵巢、皮肤、肾、窦、结肠、肠、胃、直肠、食道、心、脾、唾液腺、血液、大脑和其覆盖物、脊髓和其覆盖物、肌肉、结缔组织、肾上腺、副甲状腺、甲状腺、子宫、睾丸、垂体、生殖器、肝脏、胆囊、眼、耳、鼻、喉、扁桃腺、口、淋巴结和淋巴组织。

12.如权利要求9所述的应用，其特征在于，所述疾病是受病毒、细菌或寄生虫改变的组织，这些组织选自肺、乳房、胃、胰、前列腺、膀胱、骨、卵巢、皮肤、肾、窦、结肠、肠、胃、直肠、食道、心、脾、唾液腺、血液、大脑和其覆盖物、脊髓和其覆盖物、肌肉、结缔组织、肾上腺、副甲状腺、甲状腺、子宫、睾丸、垂体、生殖器、肝脏、胆囊、眼、耳、鼻、喉、扁桃腺、口、淋巴结和淋巴组织。

13.如权利要求9所述的应用，其特征在于，所述疾病是选自以下组织的畸形：即肺、乳房、胃、胰、前列腺、膀胱、骨、卵巢、皮肤、肾、窦、结肠、肠、胃、直肠、食道、心、脾、唾液腺、血液、大脑和其覆盖物、脊髓和其覆盖物、肌肉、结缔组织、肾上腺、副甲状腺、甲状腺、子宫、睾丸、垂体、生殖器、肝脏、胆囊、眼、耳、鼻、喉、扁桃腺、口、淋巴结和淋巴组织。

14.如权利要求10所述的应用，其特征在于，所述组织是淋巴组织。

15.如权利要求9所述的应用，其特征在于，所述疾病是扁桃体肥大。

16.如权利要求9所述的应用，其特征在于，所述疾病是前列腺增生。

17.如权利要求9所述的应用，其特征在于，所述疾病是银屑病。

18.如权利要求9所述的应用，其特征在于，所述疾病是湿疹。

19.如权利要求9所述的应用，其特征在于，所述疾病是皮肤病。

20.如权利要求9所述的应用，其特征在于，所述疾病是对组织的整容修饰。

21.如权利要求10所述的应用，其特征在于，所述组织是皮肤、眼、耳、鼻、喉、口、肌肉、结缔组织和乳房。

22.如权利要求9所述的应用，其特征在于，所述疾病是血管病。

23.如权利要求9所述的应用，其特征在于，所述疾病是痔。

24.如权利要求9所述的应用，其特征在于，所述疾病是静脉曲张。

25.如权利要求22所述的应用，其特征在于，所述血管病是动脉粥样硬化或动脉硬化。

26.如权利要求9所述的应用，其特征在于，所述疾病选自炎性疾病、自身免疫疾病、代谢疾病、遗传疾病、创伤性疾病或身理损伤、营养缺乏性疾病、传染病、淀粉样变疾病、纤维变性病、贮积病、先天性畸形、酶缺乏性疾病、中毒、致醉、环境病、辐射病、内分泌疾病、变性疾病和机械性损伤疾病。

27.如权利要求9所述的应用，其特征在于，所述肽衍生自胰丝状蛋白的氨基酸序列。

28.如权利要求9所述的应用，其特征在于，所述肽偶联于、连接于或结合于选自抗体、抗体片段和抗体样结合分子的分子，其中所述分子与肿瘤或其它靶结合的亲和力高于与其它细胞结合的亲和力。

29.如权利要求9所述的应用，其特征在于，所述肽是一新克隆的重组分子的一部分，该重组分子由所述肽和选自抗体、抗体片段和抗体样结合分子的分子组成，其中所述分子与肿瘤或其它靶结合的亲和力高于与其它细胞结合的亲和力。

30.一种肽，其特征在于，所述肽含有具有SEQ ID NO：18：Gln-Gln-Ser-Ile-Ala-Val-Lys-Phe-Leu-Ala-Val-Phe-Gly-Val-Ser-Ile所代表的氨基酸序列的肽。