CN100414232C - Vacuum spray drying method for liquid material and vacuum continuous spray drying machine - Google Patents
Vacuum spray drying method for liquid material and vacuum continuous spray drying machine Download PDFInfo
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- CN100414232C CN100414232C CNB2004100521306A CN200410052130A CN100414232C CN 100414232 C CN100414232 C CN 100414232C CN B2004100521306 A CNB2004100521306 A CN B2004100521306A CN 200410052130 A CN200410052130 A CN 200410052130A CN 100414232 C CN100414232 C CN 100414232C
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Abstract
The present invention relates to a vacuum spray drying method and a vacuum continuous spray drying machine for liquid materials. The liquid materials enter a heated tank body of which the vacuum is pumped in advance from the continuous spray of a high-speed centrifugal spray head by a material preheater so as to carry out vacuum continuous spray drying. The drying machine comprises the tank body and an electric control box of temperature and vacuum, wherein an air heater is communicated with the tank body through a pipeline by an air filter; the tank body is provided with a liquid material inlet and a spray head; a vacuum pump is connected with a pumping vacuum opening of the tank body through the pipeline. The present invention has the advantages of continuousness, low temperature, rapidness, low energy consumption, reasonable process, wide application scope, etc., and is particularly suitable for spray drying of a filtration sterilization solution to form asepsis medicinal powder so as to replace a freezing drying method. The present invention can save lots of work time, can exponentially improve production, is an ideal drying device for temperature sensitive and easy oxidation materials with high sugar content. The spray drying machine is provided with a self-control system of temperature and vacuum so as to ensure the constant running and energy conservation of the entire machine.
Description
(1) technical field
The present invention relates to a kind of Liquidness Supplying Vaccum Spraying Drying Method And Vacuum Consecutive Spraying Drier, the low temperature, the rapid draing that are mainly used in aqueous materials such as medicine, Chinese medicine liquid extract, industrial chemicals, raw-food material are handled, the low temperature, rapid draing that also can be used for other material are handled, and are temperature-sensitive, readily oxidizable substance, contain the desirable drying equipment of sugar part high material.
(2) background technology
At present, the drying of aqueous medicine, Chinese medicine liquid extract, industrial chemicals, raw-food material mainly contains the normal pressure Highspeedcentrifugingandsprayingdrier, Airstreamsprayingdrier carries out spray-drying, owing to be the normal pressure spray drying, the hot-air that enters in the dry tank body must reach more than 130 ℃, the vaporific liquid pearl vaporization of the imperceptible material that sprays into is separated, and outlet temperature reaches more than 80～90 ℃ just can make dry materials.Because the temperature height, destroy material easily, especially to temperature-sensitive, easily oxidation, to contain sugar part high material inapplicable; In addition because tank body is big, need the air heater of tens KW power and powerful air blast, air exhauster, energy consumption height, noise be big, it is big to pollute.
(3) summary of the invention
For overcome existing normal pressure spray drying machine temperature height, to material instability, energy consumption height, big, the heavy-polluted deficiency of noise, the invention provides a kind of continuously, low temperature, fast, low energy consumption, technology be reasonable, widely applicable, can be fit to temperature-sensitive, easily oxidation, contain the high Liquidness Supplying Vaccum Spraying Drying Method And Vacuum Consecutive Spraying Drier of sugared part.
Aqueous material vacuum spray drying method by this purpose design is characterized in that: carry out drying by the continuous spray dryer of vacuum; Aqueous material is sprayed continuously to enter in advance in the tank body that vacuumizes, also heats from the high speed centrifugation fog-spray nozzle through material preheater and is carried out the continuous spray-drying of vacuum; Open air heater during use earlier, and unlatching vacuumizes continuously, air through heating is entered in the tank body, make the interior temperature of tank body reach 30～120 ℃, when vacuum reaches 10KPa～95KPa, open the high speed centrifugation fog-spray nozzle, make through material preheater be heated to 30～120 ℃ aqueous material continuously spraying enter in the tank body, owing to be in certain vacuum state in the tank body, the separation so the aqueous material that sprays into can be vaporized rapidly under 35～80 ℃ temperature, water vapour is outside vacuum orifice is drawn out of tank body, material is dried in the material sinking process because the effect of gravity sinks to the dried material gatherer of tank body bottom.
Temperature is that 40～80 ℃, vacuum are that 20KPa～80KPa, material preheat temperature are 35～80 ℃ in the preferred tank body.Temperature is that 35～50 ℃, vacuum are that 30KPa～60KPa, material preheat temperature are 40～60 ℃ in the another kind of preferred tank body.
The continuous spray dryer of vacuum by this purpose design, comprise the tank body, temperature and the vacuum electric cabinet that are provided with heat-insulation layer, tank body is provided with observation window and jar intraoral illumination lamp, air heater communicates with tank body through air cleaner by pipeline, its architectural feature is that tank body is provided with aqueous material inlet and fog-spray nozzle, and vavuum pump links to each other with the tank body vacuum orifice by pipeline.
Described tank body is a turbination, the bottom is provided with dried material gatherer and valve, top or middle part or bottom one side are provided with hot air inlet, and center of top is provided with aqueous material inlet and fog-spray nozzle, and top one side or top or middle part or bottom are provided with vacuum orifice.Described aqueous material porch is provided with material preheater.Described fog-spray nozzle comprises high speed centrifugation sprayer and air-stream spraying head.Described air cleaner is middle effect air cleaner or high efficiency particle air filter; Described tank body also is provided with silicone oil heater or the electric airheater that refluxes by its interlayer.
Its operation principle is: air is through heating and filtration, be evacuated and enter in the dry tank body, hot-air evenly distributes in the dry tank body, and aqueous material is sprayed into imperceptible vaporific liquid pearl through the high speed centrifugation atomizer (fog-spray nozzle) at tank body top, contacts with hot-air and stream.Owing to be in certain vacuum state in the tank body, the separation so the imperceptible vaporific liquid pearl that sprays into can be vaporized rapidly under 35～80 ℃ low temperature, water vapour is outside vacuum orifice is drawn out of tank body, material is because the gravity effect sinks in the dried material gatherer, material sinking process of tank body bottom is dried rapidly, reaches low temperature, the purpose of continuous drying fast.
The present invention has the following advantages compared to existing technology:
1, technology is reasonable, widely applicable, not only is applicable to the vacuum spray drying of general aqueous material but also is applicable to temperature-sensitive, easily oxidation, contains the vacuum spray drying of sugar part high aqueous material that material performance is not had influence.
2, simple and compact equipment structure, be convenient to maintenance, easy to operate, be easy to washing and sterilizing, be particularly suitable for the filtration sterilization solution spray and be dried to aseptic powder, substitute freeze-drying, save a large amount of man-hours and significantly improve output.
3, required hot air temperature is low, does not need air blast and air exhauster, thereby energy consumption is low, noiseless, pollution are little.
4, this machine is equipped with temperature, vacuity auto-control system, automatically temperature, vacuum is remained within the scope of defined, reduces temperature heat time heating time, energy savings.
(4) description of drawings
Accompanying drawing is one embodiment of the invention structural representation.
(5) specific embodiment
Below in conjunction with drawings and Examples the present invention is described in further detail.
Referring to accompanying drawing, the continuous spray dryer of this vacuum comprises that the tank body 5, the tank body 5 that are provided with heat-insulation layer 3 are provided with observation window 4 and jar intraoral illumination lamp 7.Tank body 5 is a turbination, the bottom is provided with dried material gatherer 1 and valve 2, middle and lower part one side is provided with hot air inlet 14, center of top is provided with aqueous material inlet 10 and fog-spray nozzle 6, fog-spray nozzle comprises high speed centrifugation sprayer and air-stream spraying head, and aqueous material porch also is provided with material preheater 11.Top one side is provided with vacuum orifice 9.Air heater 16 communicates through the hot air inlet 14 of air cleaner 13 with tank body 5 bottoms by pipeline, and air cleaner 13 is middle effect air cleaner or high efficiency particle air filter.
The hot air inlet 14 of air heater 16 of the present invention can be best with the middle part at other any position of tank body 5 also.Vacuum orifice 9 can also be at other any position of tank body 5 except that tank body 5 tops.Aqueous material enters before the fog-spray nozzle 6, also can directly enter the spraying vacuum drying chamber without material preheater 11 preheatings (not establishing material preheater).
This implementation and operation process can be observed the continuous spray-drying process of whole vacuum from observation window 4 under the illumination of the illuminating lamp 7 at tank body 5 tops, temperature required, vacuum is regulated by temperature, vacuity auto-control system and realized automatic constant control.
Provide several concrete dry embodiment below:
Embodiment one: " lactose solution " carried out dry situation, and its data are as follows:
Lactose solution: contain lactose 8%; Water content 92%
Temperature in the tank body: 40～60 ℃ of vacuum: 40KPa～80KPa
Material preheat temperature: 40～60 ℃
Final dry " lactose " powder water content: 6%
Effect: enhance productivity (and the easy gelatinization of conventional centrifugal spray dryer drying method, can't be dry)
Embodiment two: " injection aceglutamide " carried out dry situation, and its data are as follows:
The aseptic process of " injection aceglutamide " solution: make sterile solution, material moisture 74.2% with 0.2 μ filtering with microporous membrane degerming;
Tank body, pipeline are through cleaning, sterilizing;
Temperature in the dry tank body: 35～50 ℃ of vacuum: 40KPa～80KPa
Material preheat temperature: 35～50 ℃
Final " injection aceglutamide " aseptic powder water content: 4%.
Effect: enhance productivity, 55 hours consuming time of a collection of need of freeze drying, and only need 5 hours with the continuous spray drying process of vacuum, enhance productivity 10 times.
Embodiment three: " herbal mixture hypoglycemic king " aqueous extract is carried out dry situation, and its data are as follows:
Herbal mixture hypoglycemic chloroazotic acid medicinal extract:
Density: 1.15～1.35g/cm
3Water content: 38%
Temperature in the tank body: 50～80 ℃; Vacuum: 30KPa～60KPa;
Material preheat temperature: 50～80 ℃;
Final water content: 3%.
Effect: enhance productivity 〉=2 times;
Embodiment four: " heart kidney treasured " pure medicinal extract (65% ethanol) is carried out dry situation, and its data are as follows:
" heart kidney treasured " pure medicinal extract:
Density: 1.15～1.35g/cm
3Water content: 32%
Temperature in the tank body: 45～70 ℃; Vacuum: 30KPa～60KPa;
Material preheat temperature: 45～70 ℃;
Final water content: 3%.
Effect: enhance productivity: 〉=2 times.
Claims (9)
1. an aqueous material vacuum spray drying method is characterized in that: carry out drying by the continuous spray dryer of vacuum; Aqueous material is sprayed continuously to enter in advance in the tank body that vacuumizes, also heats from the high speed centrifugation fog-spray nozzle through material preheater and is carried out the continuous spray-drying of vacuum; Open air heater during use earlier, and unlatching vacuumizes continuously, air through heating is entered in the tank body, make the interior temperature of tank body reach 30～120 ℃, when vacuum reaches 10KPa～95KPa, open the high speed centrifugation fog-spray nozzle, make through material preheater be heated to 30～120 ℃ aqueous material continuously spraying enter in the tank body, owing to be in certain vacuum state in the tank body, the separation so the aqueous material that sprays into can be vaporized rapidly under 35～80 ℃ temperature, water vapour is outside vacuum orifice is drawn out of tank body, material is dried in the material sinking process because the effect of gravity sinks to the dried material gatherer of tank body bottom.
2. vacuum spray drying method according to claim 1 is characterized in that: temperature is that 40～80 ℃, vacuum are that 20KPa～80KPa, material preheat temperature are 35～80 ℃ in the tank body.
3. vacuum spray drying method according to claim 1 is characterized in that: temperature is that 35～50 ℃, vacuum are that 30KPa～60KPa, material preheat temperature are 40～60 ℃ in the tank body.
4. continuous spray dryer of vacuum, comprise the tank body (5), temperature and the vacuum electric cabinet (17) that are provided with heat-insulation layer (3), tank body is provided with observation window (4) and jar intraoral illumination lamp (7), air heater (16) communicates with tank body through air cleaner (13) by pipeline, it is characterized in that tank body is provided with aqueous material inlet (10) and fog-spray nozzle (6), vavuum pump links to each other with tank body vacuum orifice (9) by pipeline.
5. the continuous spray dryer of vacuum according to claim 4, it is characterized in that described tank body is a turbination, the bottom is provided with dried material gatherer (1) and valve (2), top or middle part or bottom one side are provided with hot air inlet (14), center of top is provided with aqueous material inlet and fog-spray nozzle, and top one side or top or middle part or bottom are provided with vacuum orifice.
6. according to claim 4 or the continuous spray dryer of 5 described vacuum, it is characterized in that described aqueous material porch is provided with material preheater (11).
7. the continuous spray dryer of vacuum according to claim 4 is characterized in that described fog-spray nozzle comprises high speed centrifugation sprayer and air-stream spraying head.
8. the continuous spray dryer of vacuum according to claim 4 is characterized in that described air cleaner is middle effect air cleaner or high efficiency particle air filter; Described tank body also is provided with silicone oil heater or the electric airheater that refluxes by its interlayer.
9. the continuous spray dryer of vacuum according to claim 4, it is characterized in that described temperature and vacuum electric cabinet (17) are provided with temperature, vacuum automatic control and temperature, vacuum insurance two-step mechanism, it comprises temperature, vacuum regulation meter, thermal sensible element and electric elements.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100521306A CN100414232C (en) | 2004-11-05 | 2004-11-05 | Vacuum spray drying method for liquid material and vacuum continuous spray drying machine |
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| CNB2004100521306A CN100414232C (en) | 2004-11-05 | 2004-11-05 | Vacuum spray drying method for liquid material and vacuum continuous spray drying machine |
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| CN1616910A CN1616910A (en) | 2005-05-18 |
| CN100414232C true CN100414232C (en) | 2008-08-27 |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2015063090A2 (en) | 2013-10-28 | 2015-05-07 | Chr. Hansen A/S | Drying of microorganisms |
| CN104896877B (en) * | 2015-06-24 | 2017-01-18 | 江南大学 | Ultrasonic atomizing and pulse microwave vacuum drying device for liquid material and drying method |
| CN107462028A (en) * | 2017-07-21 | 2017-12-12 | 河南科威阻燃新材料有限公司 | A kind of drying system and technique of dustless microcapsule coated red phosphorus combustion inhibitor |
| CN109394707A (en) * | 2018-12-26 | 2019-03-01 | 四川制药制剂有限公司 | A kind of manufacturing method of injection caspofungin acetate |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4250628A (en) * | 1979-06-21 | 1981-02-17 | Smith Richard D | Microwave fabric dryer method and apparatus |
| CN2396882Y (en) * | 1999-06-10 | 2000-09-20 | 沈善明 | Vacuum low-temp. spray-drying granulation machine |
| JP2004082005A (en) * | 2002-08-27 | 2004-03-18 | Tdk Corp | Granulation method and equipment by spray drying and device |
| DE10241447A1 (en) * | 2002-09-06 | 2004-03-18 | Rähse, Wilfried, Dr. | Flash-drying ultra-fine dry powder comprising mixture of ingredients involves using specific temperature and pressure conditions |
| CN2650039Y (en) * | 2003-08-01 | 2004-10-20 | 李华国 | Vacuum spray microwave drying system |
| CN2745008Y (en) * | 2004-11-05 | 2005-12-07 | 刘贤英 | Vacuum continuous spray drying machine |
-
2004
- 2004-11-05 CN CNB2004100521306A patent/CN100414232C/en not_active Expired - Fee Related
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4250628A (en) * | 1979-06-21 | 1981-02-17 | Smith Richard D | Microwave fabric dryer method and apparatus |
| CN2396882Y (en) * | 1999-06-10 | 2000-09-20 | 沈善明 | Vacuum low-temp. spray-drying granulation machine |
| JP2004082005A (en) * | 2002-08-27 | 2004-03-18 | Tdk Corp | Granulation method and equipment by spray drying and device |
| DE10241447A1 (en) * | 2002-09-06 | 2004-03-18 | Rähse, Wilfried, Dr. | Flash-drying ultra-fine dry powder comprising mixture of ingredients involves using specific temperature and pressure conditions |
| CN2650039Y (en) * | 2003-08-01 | 2004-10-20 | 李华国 | Vacuum spray microwave drying system |
| CN2745008Y (en) * | 2004-11-05 | 2005-12-07 | 刘贤英 | Vacuum continuous spray drying machine |
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| CN1616910A (en) | 2005-05-18 |
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| EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Qingyuan Jiabo Pharmaceutical Co., Ltd. Assignor: Liu Xianying|Liu Xiandian Contract fulfillment period: 2008.8.28 to 2018.8.27 contract change Contract record no.: 2008440000420 Denomination of invention: Vacuum spray drying method for liquid material and vacuum continuous spray drying machine Granted publication date: 20080827 License type: Exclusive license Record date: 2008.12.4 |
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Free format text: EXCLUSIVE LICENSE; TIME LIMIT OF IMPLEMENTING CONTACT: 2008.8.28 TO 2018.8.27; CHANGE OF CONTRACT Name of requester: QINGYUAN JIABO PHARMACEUTICAL CO., LTD. Effective date: 20081204 |
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Granted publication date: 20080827 Termination date: 20141105 |
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