CN100352524C - Micro-dialysis device with dialysis film protection - Google Patents
Micro-dialysis device with dialysis film protection Download PDFInfo
- Publication number
- CN100352524C CN100352524C CNB2005100491786A CN200510049178A CN100352524C CN 100352524 C CN100352524 C CN 100352524C CN B2005100491786 A CNB2005100491786 A CN B2005100491786A CN 200510049178 A CN200510049178 A CN 200510049178A CN 100352524 C CN100352524 C CN 100352524C
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- China
- Prior art keywords
- dialysis membrane
- hole
- guide tube
- base
- probe
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000502 dialysis Methods 0.000 title claims abstract description 45
- 238000001690 micro-dialysis Methods 0.000 title claims abstract description 23
- 239000000523 sample Substances 0.000 claims abstract description 37
- 239000012528 membrane Substances 0.000 claims abstract description 23
- 239000007788 liquid Substances 0.000 claims abstract description 14
- 239000011347 resin Substances 0.000 claims abstract description 9
- 229920005989 resin Polymers 0.000 claims abstract description 9
- 230000001681 protective effect Effects 0.000 claims abstract description 8
- 238000005452 bending Methods 0.000 abstract description 4
- 230000037431 insertion Effects 0.000 abstract 1
- 238000003780 insertion Methods 0.000 abstract 1
- NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 description 7
- 239000000385 dialysis solution Substances 0.000 description 5
- 239000000463 material Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 239000004677 Nylon Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 229920001778 nylon Polymers 0.000 description 2
- 239000003708 ampul Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000003701 histiocyte Anatomy 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 210000001503 joint Anatomy 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
- 239000010453 quartz Substances 0.000 description 1
- 239000004627 regenerated cellulose Substances 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Images
Landscapes
- External Artificial Organs (AREA)
Abstract
本发明涉及带有透析膜保护的微透析装置，该装置包括由同轴线装置的进液管、半渗透的管状透析膜、支撑出液管、透析膜保护套管和探针基座组成的微透析探针及由引导管基座和引导管组成的引导管组件，管状透析膜的下端密封，上端插入支撑出液管的下端口并用树脂粘贴，透析膜保护套管套在支撑出液管及管状透析膜外。引导管的一段置入引导管基座通孔中，另一段露于通孔外，通孔中留有供透析膜保护套管插入的空间，引导管与透析膜保护套管的内径和外径相同。该装置中的管状透析膜由于有保护套管保护，因此在管状透析膜插入和抽出引导管操作过程中，可有效防止管状透析膜受力弯折受损。
The invention relates to a microdialysis device with dialysis membrane protection, which comprises a liquid inlet pipe of a coaxial device, a semi-permeable tubular dialysis membrane, a supporting outlet pipe, a dialysis membrane protection sleeve and a probe base. The microdialysis probe and the guide tube assembly composed of the guide tube base and the guide tube, the lower end of the tubular dialysis membrane is sealed, the upper end is inserted into the lower port of the supporting outlet tube and pasted with resin, and the protective sleeve of the dialysis membrane is covered on the supporting outlet tube And outside the tubular dialysis membrane. One section of the guide tube is placed in the through hole of the guide tube base, and the other section is exposed outside the through hole. There is a space for the insertion of the dialysis membrane protection sleeve in the through hole. The inner diameter and outer diameter of the guide tube and the dialysis membrane protection sleeve same. Since the tubular dialysis membrane in the device is protected by a protective sleeve, it can effectively prevent the tubular dialysis membrane from being damaged due to force bending during the operation of inserting and pulling out the guide tube.
Description
Technical field
The present invention relates to micro-dialysis device, belong to medical apparatus and instruments.
Background technology
Micro-dialysis device is can pass through semipermeable membrane with micromolecule and water, along Concentraton gradient spread and macromolecular substances can not to see through semipermeable membrane be a kind of chemical substance sampling apparatus that the basis is designed.When the tubulose dialyzer of minor diameter being implanted in the animal body behind the specific region, with artificial dialysis solution continous perfusion, then the small-molecule substance in the outer liquid of histiocyte forms Concentraton gradient in the semipermeable membrane both sides, and suitable Concentraton gradient diffuses into dialysis solution, and taken out of external by dialysis solution, by analysis, can calculate the concentration level of this material in the outer liquid of in-vivo tissue to content of material in the dialysis solution.This technology is applied to monitor the research of interior chemical micro-environment variation of body and drug mechanism.
Micro-dialysis device comprises microdialysis probe and guiding tube assembly two parts, because the internal diameter of guiding tube is below 1mm, when microdialysis probe being inserted guiding tube or extracting out, often make the stressed bending of feed tube that is exposed to outer dialyzer and containing thereof of probe and dialyzer is broken or feed tube fractures.CN1139883A discloses a kind of device of protecting microdialysis probe to be without prejudice in inserting tissue, but this device is not suitable for chronic experiment, and when probe is extracted in body probe is not added to protect and predispose to damage.
Summary of the invention
The purpose of this invention is to provide a kind of micro-dialysis device that has dialysis film protection.
The micro-dialysis device that has dialysis film protection of invention; comprise microdialysis probe and guiding tube assembly two parts; it is characterized in that: microdialysis probe is by the feed tube of coaxial line device; semi permeable tubulose dialyzer; support drain pipe; dialysis film protection sleeve pipe and probe base are formed; probe base has the stairstepping cylindrical hole; an end that supports drain pipe is an inclined tube; support the through hole that drain pipe passes through probe base; its inclined tube is exposed to the top of probe base through hole; the lower end sealing of tubulose dialyzer; the upper end of tubulose dialyzer is inserted the lower port of support drain pipe and is pasted with resin; feed tube places and supports drain pipe; its lower end extends in the tubulose dialyzer pipe; the upper end passes the areole that supports drain pipe; insert in the protective casing; the inclined tube of feed tube upper end and support drain pipe is fixed into one with resin and probe base; the dialysis film protection casing pipe sleeve is outside supporting drain pipe; be slidingly matched with the support drain pipe; between its upper end and probe base flexible tie is arranged; the big column hole inwall of telescopic outer wall of dialysis film protection and probe base through hole is slidingly matched; the guiding tube assembly is made up of guiding tube pedestal and guiding tube; the guiding tube pedestal has through hole; the internal diameter of guiding tube is identical with external diameter with the telescopic internal diameter of external diameter and dialysis film protection; one section receiving through-hole of guiding tube is also fixed with through hole; another section is exposed to outside the through hole, leaves the space of inserting for the dialysis film protection sleeve pipe in the through hole.
During use; earlier guiding tube is inserted in the specified in-vivo tissue with stereotaxic instrument; dialysis film protection sleeve pipe with microdialysis probe inserts in the guiding tube pedestal hole then; this moment the dialysis film protection sleeve pipe with complete concentric butt joint of guiding tube; supporting drain pipe slides along the dialysis film protection sleeve pipe under external force; tubulose dialyzer and support drain pipe pass guiding tube, insert in the interior specified tissue of body.When microdialysis probe was extracted out from guiding tube, in the tubulose dialyzer elder generation withdrawal dialysis film protection pipe, the dialysis film protection pipe broke away from the guiding tube pedestal under the traction of flex link then.Because the dialysis film protection casing protection is arranged, so the tubulose dialyzer can not contact with guiding tube pedestal and guiding tube inserting and extracting out in the guiding tube operating process, can prevent effectively that the stressed bending of tubulose dialyzer is impaired.
Description of drawings
Fig. 1 is the micro-dialysis device structural representation that has dialysis film protection.
The specific embodiment
With reference to Fig. 1; the micro-dialysis device that has dialysis film protection comprises microdialysis probe and guiding tube assembly two parts; microdialysis probe is by the feed tube 2 of coaxial line device; semi permeable tubulose dialyzer 7; support drain pipe 5; dialysis film protection sleeve pipe 6 and probe base 3 are formed; probe base 3 has stairstepping cylindrical hole 4; an end that supports drain pipe 5 is an inclined tube; this supports drain pipe can use external diameter 0.5mm; the stainless steel tube bending of internal diameter 0.3mm is made; in crooked position punching 15; support the through hole 4 that drain pipe 5 passes through probe base 3; its inclined tube is exposed to the top of probe base 3 through holes; this inclined tube is used to discharge dialysis solution; the lower end of tubulose dialyzer 7 seals with resin; the lower port that supports drain pipe 5 is inserted in the upper end of tubulose dialyzer; and paste with resin; usually; the material of tubulose dialyzer is a regenerated cellulose; external diameter 0.2-0.3mm; internal diameter 0.15-0.2mm; feed tube 2 places and supports drain pipe 5; its lower end extends in tubulose dialyzer 7 pipes and near Feng Miduan; the length of feed tube 2 in the tubulose dialyzer is effective dialysis length of dialyzer; be generally 2-10mm; the upper end of feed tube 2 passes the areole 15 that supports drain pipe 5; insert in the protective casing 1, the inclined tube of feed tube 2 upper ends and support drain pipe 5 is fixed into one with resin 8 and probe base 3.Feed tube 2 can adopt the capillary quartz ampoule.Dialysis film protection sleeve pipe 6 is enclosed within and supports outside the drain pipe 5; be slidingly matched with support drain pipe 5; its upper end and 3 of probe bases have nylon tie 11; like this; when the dialysis film protection sleeve pipe when supporting drain pipe and slide; by the definite highest distance position that slides of nylon tie, can guarantee that the dialysis film protection sleeve pipe can not break away from the support drain pipe simultaneously.The big column hole inwall of the outer wall of dialysis film protection sleeve pipe 6 and probe base through hole 4 is slidingly matched.The guiding tube assembly is made up of guiding tube pedestal 14 and guiding tube 12; guiding tube pedestal 14 has through hole 13; the internal diameter of guiding tube 12 is identical with the internal diameter and the external diameter of dialysis film protection sleeve pipe 6 with external diameter; one section receiving through-hole 13 of guiding tube 12 is also pasted fixing with through hole with resin; another section is exposed to outside the through hole, leaves the space of inserting for dialysis film protection sleeve pipe 6 in the through hole 13.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100491786A CN100352524C (en) | 2005-03-04 | 2005-03-04 | Micro-dialysis device with dialysis film protection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100491786A CN100352524C (en) | 2005-03-04 | 2005-03-04 | Micro-dialysis device with dialysis film protection |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1663628A CN1663628A (en) | 2005-09-07 |
| CN100352524C true CN100352524C (en) | 2007-12-05 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2005100491786A Expired - Fee Related CN100352524C (en) | 2005-03-04 | 2005-03-04 | Micro-dialysis device with dialysis film protection |
Country Status (1)
| Country | Link |
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| CN (1) | CN100352524C (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100336491C (en) * | 2006-08-30 | 2007-09-12 | 郑军 | Protection device for encephalic micro-dialysis |
| GB2442209B (en) * | 2006-09-28 | 2012-01-18 | Probe Scient Ltd | Molecular exchange device |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996010948A1 (en) * | 1994-10-06 | 1996-04-18 | Universite Henri Poincare, Nancy 1 | Device for measuring simultaneously the tissue blood flow rate and the extra-cellular liquid composition |
| WO1996033405A1 (en) * | 1995-04-17 | 1996-10-24 | Mayo Foundation For Medical Education And Research | Sample preprocessor |
| CN2281761Y (en) * | 1996-07-09 | 1998-05-20 | 郭述苏 | Micro dialysis probe |
| EP1346745A1 (en) * | 2002-03-21 | 2003-09-24 | Ed. Geistlich Söhne Ag Für Chemische Industrie | Apparatus for treatment of tumor in the central nervous system (CNS) |
| CN1142421C (en) * | 2000-12-18 | 2004-03-17 | 中国科学院化学研究所 | Sensor type microdialysis biological living sampling device |
| CN2778289Y (en) * | 2005-03-04 | 2006-05-10 | 浙江大学 | Micro-dialysis device with dialysis film protection |
-
2005
- 2005-03-04 CN CNB2005100491786A patent/CN100352524C/en not_active Expired - Fee Related
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996010948A1 (en) * | 1994-10-06 | 1996-04-18 | Universite Henri Poincare, Nancy 1 | Device for measuring simultaneously the tissue blood flow rate and the extra-cellular liquid composition |
| WO1996033405A1 (en) * | 1995-04-17 | 1996-10-24 | Mayo Foundation For Medical Education And Research | Sample preprocessor |
| CN2281761Y (en) * | 1996-07-09 | 1998-05-20 | 郭述苏 | Micro dialysis probe |
| CN1142421C (en) * | 2000-12-18 | 2004-03-17 | 中国科学院化学研究所 | Sensor type microdialysis biological living sampling device |
| EP1346745A1 (en) * | 2002-03-21 | 2003-09-24 | Ed. Geistlich Söhne Ag Für Chemische Industrie | Apparatus for treatment of tumor in the central nervous system (CNS) |
| CN2778289Y (en) * | 2005-03-04 | 2006-05-10 | 浙江大学 | Micro-dialysis device with dialysis film protection |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1663628A (en) | 2005-09-07 |
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Granted publication date: 20071205 Termination date: 20110304 |