CN100352498C

CN100352498C - Three dimensional eye patch for treating eye wrinkles an its preparation method

Info

Publication number: CN100352498C
Application number: CNB2005100302873A
Authority: CN
Inventors: 李青峰; 奚菁
Original assignee: University Shanghai 2nd Medical
Current assignee: University Shanghai 2nd Medical
Priority date: 2005-09-30
Filing date: 2005-09-30
Publication date: 2007-12-05
Anticipated expiration: 2025-09-30
Also published as: CN1765354A

Abstract

The invention provides a three-dimensional eye mask for treating eye wrinkles, which comprises: a three-dimensional concave-convex backing layer for loading active components; a three-dimensional concave-convex drug storage layer laid on the top of the backing layer and containing active components ; a three-dimensional concave-convex adhesive layer made of polyvinyl alcohol PVA-124 covering the drug storage layer for attaching the eye wrinkle treatment film to the skin surface; a three-dimensional concave-convex anti-adhesive layer covered on the adhesive layer . Its advantages are as follows: a three-dimensional three-dimensional mask for treating eye wrinkles is invented based on the three-dimensional shape of the eye contour. A combination of drugs studied and designed with pharmacological characteristics acts on the skin in order to open the skin channel. It is composed of drugs that regulate the skin barrier, skin conditioning drugs and small molecule polypeptide active substances, etc., to achieve the purpose of transdermal absorption, and the effect of treating skin texture and wrinkles is remarkable.

Description

A kind of 3 D stereo eye mask for the treatment of eye wrinkle-removing and preparation method thereof

Technical field

The present invention relates to the medical cosmetology field, specifically the present invention relates to a kind of 3 D stereo eye mask for the treatment of eye wrinkle-removing and preparation method thereof.

Background technology

Showing have fifty percent people to worry the matter of utmost importance of worried own skin condition in nearest Asia women's skin condition investigation report nearly, is exactly " wrinkle ".The skin of circumference of eyes is the weakest in the human body, because eye skin sweat gland and sebum distribution are less, skin is dry, so also be easy to generate most wrinkle.Eye wrinkle-removing is divided into three kinds from shallow to deep: the dry stricture of vagina that is caused by the horny layer hydropenia; Cause the wire stricture of vagina (claiming crows-feet usually) that has the acantholysis cell atrophy to produce because of the horny layer hydropenia; By the aging deep wrinkle that is produced of skin corium fiber.The method that many treatment eye wrinkle-removings are arranged at present, these treatments serve as the treatment principle to replenish the conditioning of moisture content and Chinese medicine generally.Because of the skin barrier problem, Chinese medicinal ingredients absorbs difficulty, and curative effect is limited; Present facial film technology does not consider that also failing to solve pharmaceutical compositions effectively absorbs problem.The treatment specific aim is not strong, is design with full face lamellar facial film at present, based on treatments such as mottles, no specific aims such as concrete a certain position wrinkle is treated in treatment.

Summary of the invention

The objective of the invention is to (1) a kind of 3 D stereo eye mask for the treatment of eye wrinkle-removing is provided; (2) provide a kind of preparation method for the treatment of the 3 D stereo eye mask of eye wrinkle-removing.

The objective of the invention is to realize by following technical method:

(1) a kind of compositions that contains PVAC polyvinylalcohol-124, said composition is composed of the following components by weight percentage:

PVAC polyvinylalcohol-124 5-20%

Fibroblast growth factor 30-40%

0.025% tretinoin 5-10%

Adjuvant 5-20%

Water surplus

Described adjuvant is selected from hyaluronic acid, VitE, VitC, a kind of or its mixture of Flos Carthami alcohol, (cryopreservation).

Said composition is preferably composed of the following components by weight percentage:

PVAC polyvinylalcohol-124 8-17%

Fibroblast growth factor 33-37%

0.025% tretinoin 6-9%

Adjuvant 8-17%

Water surplus

Described adjuvant is selected from hyaluronic acid, VitE, VitC, a kind of or its mixture of Flos Carthami alcohol,

(cryopreservation).

(2) a kind of compositions that contains PVAC polyvinylalcohol-124, said composition is composed of the following components by weight percentage:

PVAC polyvinylalcohol-124 5-20%

Fibroblast growth factor 30-40%

10% glycolic 5-10%

Adjuvant 5-20%

Water surplus

(cryopreservation).

PVAC polyvinylalcohol-124 8-17%

Fibroblast growth factor 33-37%

10% glycolic 6-9%

Adjuvant 8-17%

Water surplus

(cryopreservation).

(3) a kind of compositions that contains PVAC polyvinylalcohol-124, said composition is composed of the following components by weight percentage:

PVAC polyvinylalcohol-124 5-20%

Fibroblast growth factor 30-40%

12% lactic acid 5-10%

Adjuvant 5-20%

Water surplus

PVAC polyvinylalcohol-124 8-17%

Fibroblast growth factor 33-37%

12% lactic acid 6-9%

Adjuvant 8-17%

Water surplus

Described adjuvant is selected from hyaluronic acid, VitE, Vi tC, a kind of or its mixture of Flos Carthami alcohol, (cryopreservation).

Above-mentioned compositions can be used for the skin of human body according to conventional part, more is applicable to the eye wrinkle-removing film patch of making the controlled release structure.This eye wrinkle-removing film patch comprises the backing layer that is used for load active component, the above-mentioned compositions drug storing layer on backing layer top is laid in, covering being used on the drug storing layer invests the adhesive layer that skin surface PVAC polyvinylalcohol-124 is made with eye wrinkle-removing film patch, cover the adherent layer that the polyester of the silicone-treated on the adhesive layer is made, remove before the use.

The backing layer of being addressed has good barrier for containing the aluminumpolyethylene composite membrane, can prevent the leakage of medicine.

The adherent layer of being addressed is the polyester film of surface through the silicone oil release treatment.

The eye wrinkle-removing film patch preparation method may further comprise the steps:

(1) gluing: PVAC polyvinylalcohol-124 is uniformly coated on the polyester adherent layer that silicone-treated crosses intensive drying;

(2) storage medicine: PVAC polyvinylalcohol-124, medicine is water-soluble, fully stir, make the gel of pastille;

(3) press seal: the gel of pastille quantitatively is added on the above-mentioned film, covers backing film, pressurization is die-cut into suitable size, promptly gets eye wrinkle-removing film patch.

The 3 D stereo eye mask of treatment eye wrinkle-removing

(1) uses the laser three-dimensional scanning technology, at random to the seek medical advice patient of reduce wrinkle of outpatient service, carry out by the three-dimensional configuration scanning of eyebrow to the buccal, three-dimensional configuration with regard to eye socket outer rim and canthus, carry out quantitative analysis, measure, obtain the spherical radian line of eye socket outer rim radian, socket of the eye cheekbone front side angle and palpebra inferior etc.Statistical summary goes out China women's all three-dimensional datas of main eye socket.

Data: 1=122.5 ° ± 6.3 ° of eye socket outer rim arc measurement α, β 1=120.0 ° ± 7.4 °, D1=0.54 ± 0.09cm; 2=155.8 ° ± 7.2 ° of the arc measurement α of cheekbone portion, β 2=155.1 ° ± 5.7 °, D2=1.46 ± 0.24cm; The horizontal turning angle of eyebrow is measured 3=145.5 ° ± 5.4 ° of α;

The horizontal turning angle of outer canthus is measured 4=143.2 ° ± 6.7 ° of α.

(2) according to above-mentioned data: design can cover 3-4 combinations of values of 80% sample, makes three-dimensional stereo model, model according to this, and casting produces the 3 D stereo eye mask.

According to eye socket week three-dimensional data, fashion into as shown in Figure 7 3-D in convex form with PVAC polyvinylalcohol-124, this layer is three-dimensional concavo-convex adhesive layer; On the concavo-convex adhesive layer of three-dimensional outside, cover the three-dimensional concavo-convex drug storing layer of above-mentioned composition; Three-dimensional concavo-convex drug storing layer top covers three-dimensional concavo-convex backing layer; On the concavo-convex adhesive layer inner face of three-dimensional, be covered with the three-dimensional concavo-convex adherent layer that the polyester of silicone-treated is made, remove before the use.

The three-dimensional concavo-convex backing layer of being addressed has good barrier for containing the aluminumpolyethylene composite membrane, can prevent the leakage of medicine.

The three-dimensional concavo-convex adherent layer of being addressed is the polyester film of surface through the silicone oil release treatment.

The preparation method of the 3 D stereo cover of treatment eye wrinkle-removing may further comprise the steps:

(1) moulding: as, to fashion into as shown in Figure 7 3-D in convex form with PVAC polyvinylalcohol-124 according to eye socket week three-dimensional data;

(2) cover adherent layer: on the concavo-convex adhesive layer inner face of three-dimensional, be covered with the three-dimensional concavo-convex adherent layer that the polyester of silicone-treated is made;

(3) storage medicine: PVAC polyvinylalcohol-124, medicine is water-soluble, fully stir, make the gel of pastille;

(4) finished product: on the concavo-convex adhesive layer inner face of three-dimensional, cover gel, the covering backing film of pastille, promptly get the 3 D stereo eye mask for the treatment of eye wrinkle-removing.

Zoopery

1. the heavy Duroc of laboratory animal: 15kg is yellow by the hair piglets, and normal diet is fed can not be point-blank indoor in sunlight.

2. medicine: using polythene alcohol PVA-124 makes gel-type vehicle, medicine: fibroblast growth factor (trade name: Bfgf-ESSEX, be called for short BFGF) and 0.025% Avita Gel, 10% glycolic gel and 12% lactic acid gel.

3. Therapeutic Method: selecting Oculus sus domestica eyelid place skin is the Experimental Area, divides four groups, and (1) matched group sticks PVAC polyvinylalcohol-124 and makes gel.Three groups stick the eye wrinkle-removing film patch that (2) contain PVAC polyvinylalcohol-124, fibroblast growth factor, 0.025% tretinoin respectively in addition; (3) contain the eye wrinkle-removing film patch of PVAC polyvinylalcohol-124, fibroblast growth factor, 10% glycolic; (4) contain the eye wrinkle-removing film patch of PVAC polyvinylalcohol-124, fibroblast growth factor, 12% lactic acid.

4. detection method: behind application treatment, two weeks, January, February, March, skin appearance is observed, got biopsy specimen respectively, formalin fixed, paraffin embedding, section, row HE dyeing.After histological observation and statistical analysis: the HE dyeing, light microscopic is observed the variation of different times piglets epiderm skin cell and papillary layer of corium collagen tissue down.Piglets normal skin group is organized in contrast, and graphical analysis is carried out in the section of each group different times, and the meter skin thickness is analyzed comparison with method of analysis of variance.

5. result:

One. skin tissue morphology is observed

Collagen tissue all has in various degree and thickens in three treatment group papillary layer of corium, and obvious collagen band appears in part, promptly so-called Grenz band, its thickness with the application treatment time and different, arrangement of collagen fibers trends towards neat densification.

Skin tissue morphology changes behind table 1 application treatment

Medicine	Epidermal area			Papillary layer of corium
Medicine	Epidermal area			Papillary layer of corium		Time	Cell is arranged	Tightness degree	Collagen fiber
Avita Gel+BFGF	Two March February in January week	+ + + +	± ++ ++ ++	++ ++ ++ ++		Time	Cell is arranged	Tightness degree	Collagen fiber
Avita Gel+BFGF	Two March February in January week	+ + + +	± ++ ++ ++	++ ++ ++ ++	Glycolic gel+BFGF	Two March February in January week	+ ++ ++ ++	± ++ ++ ++	+ + + ++
Lactic acid gel+BFGF	Two March February in January week	± + + +	- ++ ++ ++	+ + ++ ++	Glycolic gel+BFGF	Two March February in January week	+ ++ ++ ++	± ++ ++ ++	+ + + ++
Lactic acid gel+BFGF	Two March February in January week	± + + +	- ++ ++ ++	+ + ++ ++	Matched group	Two March in February February in January week	± - - - -	- + - - -	± - - - ±

Annotate :-not obvious, irregular or disorderly; + neat, tight, clear, obvious

Two. the epidermal area thickness measure

Each treatment group skin epidermis all thickened at one month, trended towards stablizing in two months.Three months very remarkable with normal skin epidermal area difference in thickness, and The results of analysis of variance shows, P＜0.05.

(the unit: μ m) of epidermal area thickness measure behind table 1 skin treating

	Treatment two weeks of back	January after the treatment	February after the treatment	March after the treatment
	Treatment two weeks of back	January after the treatment	February after the treatment	March after the treatment	Avita Gel+BFGF	65.0766	6 8.9774	7 3.9446	79.6417
Glycolic gel+BFGF	59.2616	67.6826	69.4618	74.1861	Avita Gel+BFGF	65.0766	6 8.9774	7 3.9446	79.6417
Glycolic gel+BFGF	59.2616	67.6826	69.4618	74.1861	Lactic acid gel+BFGF	59.3276	6 3.5744	70.3396	75.4197
Matched group+BFGF	56.0114	55.9411	56.8444	54.8972	Lactic acid gel+BFGF	59.3276	6 3.5744	70.3396	75.4197

(the unit: μ m) of collagen layer thickness measure behind table 2 skin treating

	Treatment one week of back	January after the treatment	February after the treatment	March after the treatment
	Treatment one week of back	January after the treatment	February after the treatment	March after the treatment	Avita Gel+BFGF	13.498 8	17.138	20.482	24.402
Glycolic gel+BFGF	11.5191	17.414	19.712	21.374	Avita Gel+BFGF	13.498 8	17.138	20.482	24.402
Glycolic gel+BFGF	11.5191	17.414	19.712	21.374	Lactic acid gel+BFGF	12.174	15.509	19.219	22.874
Matched group+BFGF	9.28 52	9.3317	9.7421	9.5522	Lactic acid gel+BFGF	12.174	15.509	19.219	22.874

6. explanation

One. the arranging situation of epidermis cell directly has influence on the outward appearance and the quality of skin, marshalling, the skin smooth exquisiteness that seems.Simultaneously, the tightness degree of cell is related to the moisture-retaining capacity of skin, arranges the moisture content that closely can effectively prevent in the skin and runs off and evaporation, keeps the smooth and elasticity of skin.The observation of each treatment group epidermis cell is found to one to two months, the situation ideal that cell is arranged had the outward appearance and the quality of advantages of good skin.

Two. the hypertrophy of collagen fiber and rearranging, can increase the substrate in the skin corium, improve the elastic fiber quality, improve tiny wrinkle, and the wrinkle in desalination deep, increase the elasticity and the gloss of skin.To the observation of each treatment group collagen tissue, find that papillary layer of corium all has the collagen band to occur or collagen tissue thickens to some extent.

Three. epidermal area thickness has direct influence to skin quality, and epidermal area is blocked up, and it is dark and gloomy, matt that skin seems, epidermal area is thin excessively, and the skin sensitivity degree increases, and easily takes place irritated.The epidermal area of suitable thickness is the key factor that skin keeps optimum state.According to the measurement result of epidermal area thickness, can find after treatment, significantly to increase February the thickness of epidermal area.

Clinical research

Clinical treatment grouping: outpatient service eye wrinkle-removing patient is divided into four groups at random.Organize 1, contain the 3 D stereo cover of the treatment eye wrinkle-removing of PVAC polyvinylalcohol-124, fibroblast growth factor, 0.025% tretinoin; Organize 2, contain the 3 D stereo cover of the treatment eye wrinkle-removing of PVAC polyvinylalcohol-124, fibroblast growth factor, 10% glycolic; Organize 3, contain the 3 D stereo cover of the treatment eye wrinkle-removing of PVAC polyvinylalcohol-124, fibroblast growth factor, 12% lactic acid; Matched group, polyvinyl alcohol+silica gel compound

The clinical treatment method: 1, by doctor's advice, stick wrinkle place near the eyes, about 12 hours every days.As dermatitis appears, the erythema allergy sufferers is picked out experimental group.Observe in addition;

2 followed up a case by regular visits in treatment two weeks, January, February, March, filled in the observation of curative effect table, comprised the subjective curative effect table of doctor's objective determination and patient, the comprehensive statistics curative effect.

The result: pick out 3 erythema allergy sufferers altogether, the curative effect statistics is as follows:

1, curative effect statistics

Table 1: curative effect statistics *

Observing time	Curative effect	Grade	Group 1		Group 2		Group 3		Matched group
			Group 1		Group 2		Group 3		Matched group		Estimate (example)	Curative effect rate (%)	Estimate (example)	Curative effect rate (%)	Estimate (example) curative effect rate (%)	Estimate (example)	Curative effect rate (%)
			2 weeks	Effectively	Wrinkle significantly improves	12	33.75％	9	27.5％	11	Estimate (example)	Curative effect rate (%)	Estimate (example)	Curative effect rate (%)	Estimate (example) curative effect rate (%)	Estimate (example)	Curative effect rate (%)	31.25％	0	2.5％
Wrinkle partly improves	15	13			Wrinkle significantly improves	12		9		11	14	2							0
Wrinkle partly improves	15	13			Invalid	Wrinkle does not have change		53		66.25％	14	2	58	72.5％	55 68.75％	78	97.50％
1 month	Effectively	Wrinkle significantly improves		13	Invalid	Wrinkle does not have change	36.25％	53	11	66.25％	32.5％	10	58	72.5％	55 68.75％	78	97.50％	38.75％	0	1.25％
		Wrinkle significantly improves	Wrinkle partly improves	13	16	15		21	11	1		10							0
		Invalid	Wrinkle partly improves	Wrinkle does not have change	16	15		21	51	1		63.75％	54	67.5％	45 61.25％	79	98.75％
	2 months	Invalid	Effectively	Wrinkle does not have change	Wrinkle significantly improves	21	51.25％	21	51	55.0％	23	63.75％	54	67.5％	45 61.25％	79	98.75％	58.75％	0	1.25％
Wrinkle partly improves		20		23	Wrinkle significantly improves	21		21	24		23	1							0
Wrinkle partly improves		20		23	Invalid	Wrinkle does not have change		39	24		48.75％	1	36	45.0％	33 41.25％	79	98.75％
3 months		Effectively	Wrinkle significantly improves	42	Invalid	Wrinkle does not have change	85.00％	39	37	83.75％	48.75％	23	36	45.0％	33 41.25％	79	98.75％	77.5％	0	1.25％
	Wrinkle partly improves		Wrinkle significantly improves	42	26	30		39	37		1	23							0
	Wrinkle partly improves		Invalid	Wrinkle does not have change	26	30		39	12		1	15.00％	13	16.25％	18 22.5％	79	98.75％
	The observation number adds up to (example)			Wrinkle does not have change	N＝80		N＝80		12	N＝80		15.00％	13	16.25％	18 22.5％	79	98.75％	N＝80

2, statistical analysis: treatment group and matched group

Table 2. curative effect statistical analysis X ²Check
Table 2. curative effect statistical analysis X ²Check								Group 1 and matched group		Group		2 and matched group		Group	3 and matched group
	X ²Value	The P value	X ²Value	The P value	X ²Value	The P value		Group 1 and matched group		Group		2 and matched group		Group	3 and matched group
	X ²Value	The P value	X ²Value	The P value	X ²Value	The P value	2 weeks	26.32	＜0.01	19.61	＜0.01	23.57	＜0.01
1 month	32.16	＜0.01	24.94	＜0.01	35.15	＜0.01	2 weeks	26.32	＜0.01	19.61	＜0.01	23.57	＜0.01
1 month	32.16	＜0.01	24.94	＜0.01	35.15	＜0.01	2 months	51.65	＜0.01	57.17	＜0.01	62.98	＜0.01
3 months	114.39	＜0.01	111.41	＜0.01	97.42	＜0.01	2 months	51.65	＜0.01	57.17	＜0.01	62.98	＜0.01

2, statistical analysis: treatment group and treatment group are relatively

Table 3. curative effect statistical analysis X ²Check
Table 3. curative effect statistical analysis X ²Check								Group 1 and group 2		Group 1 and group 3		Group 2 and group 3
	X ²Value	The P value	X ²Value	The P value	X ²Value	The P value		Group 1 and group 2		Group 1 and group 3		Group 2 and group 3
	X ²Value	The P value	X ²Value	The P value	X ²Value	The P value	2 weeks	0.734	p＞0.25	0.11	p＞0.5	0.27	p＞0.5
1 month	0.25	p＞0.5	0.93	p＞0.25	0.68	p＞0.25	2 weeks	0.734	p＞0.25	0.11	p＞0.5	0.27	p＞0.5
1 month	0.25	p＞0.5	0.93	p＞0.25	0.68	p＞0.25	2 months	0.23	p＞0.5	0.22	p＞0.5	0.09	p＞0.5
3 months	0.47	p＞0.25	1.48	p＞0.25	1.00	p＞0.25	2 months	0.23	p＞0.5	0.22	p＞0.5	0.09	p＞0.5

The disclosed a kind of eye wrinkle-removing film patch of the present invention, its advantage shows: the drug regimen at skin physiology and the research of pharmacology characteristics, design, act on skin in order, open the skin passage.Medicine and skin condition medicine and micromolecule polypeptide class active substance etc. by the skin barrier regulation and control are formed, and to reach the purpose of Transdermal absorption, treatment skin quality and wrinkle effect are remarkable.

Description of drawings

Fig. 1 shows laser scanning solid shape figure near the eyes.

Fig. 2 shows measurement main angle and parameter of curve-eye socket outer rim radian near the eyes, and the * arrow shows each angle and parameter of curve.

Fig. 3 shows measurement main angle and parameter of curve-eye socket outer rim radian near the eyes, and the * arrow shows each angle and parameter of curve.

Fig. 4 shows measurement main angle and parameter of curve-cheekbone portion arc measurement near the eyes, and the * arrow shows each angle and parameter of curve.

Fig. 5 shows measurement main angle and the horizontal turning angle measurement of parameter of curve-eyebrow near the eyes, and the * arrow shows each angle and parameter of curve.

Fig. 6 shows measurement main angle and the horizontal turning angle measurement of parameter of curve-outer canthus near the eyes, and the * arrow shows each angle and parameter of curve.

The 3-D in male structure form of Fig. 7 display simulation.

Fig. 8 shows the structural representation of eye wrinkle-removing film patch.

Wherein: the 1-adherent layer: the 2-adhesive layer; The 3-drug storing layer; The 4-backing layer.

Fig. 9 shows the 3 D stereo eye mask structural representation for the treatment of eye wrinkle-removing.

The specific embodiment

Below in conjunction with embodiment the present invention is further described.

Embodiment 1

The component of compositions is as follows:

PVAC polyvinylalcohol-124 5g

Fibroblast growth factor 30g

0.025% tretinoin 10g

VitE、VitC 20g

Water 35g

PVAC polyvinylalcohol-124 is uniformly coated on the polyester adherent layer that silicone-treated crosses intensive drying; PVAC polyvinylalcohol-124, medicine is water-soluble, fully stir, make the gel of pastille.The gel of pastille quantitatively is added on the above-mentioned film, covers backing film, pressurization is die-cut into suitable size, promptly gets eye wrinkle-removing film patch.

Embodiment 2

The component of compositions is as follows:

PVAC polyvinylalcohol-124 20g

Fibroblast growth factor 40g

0.025% tretinoin 5g

VitE 5g

Water 30g

According to eye socket week three-dimensional data, fashion into as shown in Figure 7 3-D in convex form with PVAC polyvinylalcohol-124; On the concavo-convex adhesive layer inner face of three-dimensional, be covered with the three-dimensional concavo-convex adherent layer that the polyester of silicone-treated is made; PVAC polyvinylalcohol-124, medicine is water-soluble, fully stir, make the gel of pastille; On the concavo-convex adhesive layer inner face of three-dimensional, cover gel, the covering backing film of pastille, promptly get the 3 D stereo eye mask for the treatment of eye wrinkle-removing.

Embodiment 3

The component of compositions is as follows:

PVAC polyvinylalcohol-124 13g

Fibroblast growth factor 35g

0.025% tretinoin 7g

Flos Carthami alcohol 15g

Water 30g

Embodiment 4

The component of compositions is as follows:

PVAC polyvinylalcohol-124 20g

Fibroblast growth factor 40g

10% glycolic 5g

VitE 5g

Water 30g

Embodiment 5

The component of compositions is as follows:

PVAC polyvinylalcohol-124 13g

Fibroblast growth factor 35g

10% glycolic 7g

Flos Carthami alcohol 15g

Water 30g

Embodiment 6

The component of compositions is as follows:

PVAC polyvinylalcohol-124 5g

Fibroblast growth factor 30g

10% glycolic 10g

VitE、VitC 20g

Water 35g

Embodiment 7

The component of compositions is as follows:

PVAC polyvinylalcohol-124 5g

Fibroblast growth factor 30g

12% lactic acid 10g

Flos Carthami alcohol 20g

Water 35g

Embodiment 8

The component of compositions is as follows:

PVAC polyvinylalcohol-124 20g

Fibroblast growth factor 40g

12% lactic acid 5g

Flos Carthami alcohol 5g

Water 30g

Embodiment 9

The component of compositions is as follows:

PVAC polyvinylalcohol-124 13g

Fibroblast growth factor 35g

12% lactic acid 7g

Flos Carthami alcohol 15g

Water 30g

Claims

1, a kind of 3 D stereo eye mask for the treatment of eye wrinkle-removing is characterized in that comprising:

A three-dimensional concavo-convex backing layer that is used for load active component;

The three-dimensional concavo-convex drug storing layer of medicine activity component is contained on the backing layer top that is laid in;

One covers being used on the drug storing layer eye wrinkle-removing film patch is invested the three-dimensional concavo-convex adhesive layer that skin surface PVAC polyvinylalcohol-124 is made;

A three-dimensional concavo-convex adherent layer that covers on the adhesive layer,

Described medicine activity component, said composition is composed of the following components by weight percentage:

PVAC polyvinylalcohol-124 5-20%

Fibroblast growth factor 30-40%

0.025% tretinoin 5-10%

Adjuvant 5-20%

Water surplus

Described adjuvant is selected from hyaluronic acid, VitE, VitC, a kind of or its mixture of Flos Carthami alcohol.

2, a kind of 3 D stereo eye mask for the treatment of eye wrinkle-removing is characterized in that comprising:

PVAC polyvinylalcohol-124 5-20%

Fibroblast growth factor 30-40%

10% glycolic 5-10%

Adjuvant 5-20%

Water surplus

3, a kind of 3 D stereo eye mask for the treatment of eye wrinkle-removing is characterized in that comprising:

PVAC polyvinylalcohol-124 5-20%

Fibroblast growth factor 30-40%

12% lactic acid 5-10%

Adjuvant 5-20%

Water surplus

4, according to the 3 D stereo eye mask of each described treatment eye wrinkle-removing of claim 1-3, it is characterized in that: three-dimensional concavo-convex backing layer is for containing the aluminumpolyethylene composite membrane.

5, according to the 3 D stereo eye mask of each described treatment eye wrinkle-removing of claim 1-3, it is characterized in that: the concavo-convex adherent layer of described three-dimensional is the polyester film of surface through the silicone oil release treatment.

6, according to the preparation method of the 3 D stereo eye mask of each described treatment eye wrinkle-removing of claim 1-3, it is characterized in that, may further comprise the steps:

(1) according to eye socket week three-dimensional data, fashions into the 3-D in convex form with PVAC polyvinylalcohol-124;

(2) on the concavo-convex adhesive layer inner face of three-dimensional, be covered with the three-dimensional concavo-convex adherent layer that the polyester of silicone-treated is made;

(3) PVAC polyvinylalcohol-124, medicine is water-soluble, fully stir, make the gel of pastille;

(4) gel of covering pastille, covering backing film on the concavo-convex adhesive layer inner face of three-dimensional promptly get the 3 D stereo eye mask for the treatment of eye wrinkle-removing.