CN100341529C - Combination of Tibet medicine of containing salt and possessing medicinal effect health care, and preparation metohd - Google Patents

Abstract

The present invention discloses a composition of Tibet medicine containing salt and a preparation method thereof. The composition has a health care function. The composition of Tibet medicine contains salt, juniper, myricaria germanica, rhododendron, large seed artemisia, etc. A medicinal bath salt product prepared by the method of the present invention has the advantages of stable technology and high and controlled quality, and is favorable for ensuring a therapeutic effect. The bath salt of the present invention has the efficacy of expelling rheumatism, tranquilizing spirit, promoting sleep, beautifying faces, reducing weight and increasing immunization. The bath salt of the present invention can promote the blood circulation of a body, increase heat energy, and resist chill invasion, and the bath salt of the present invention has the efficacy of coolness and heat clearing in summer.

Description

A saline-containing Tibetan medicine composition with medicinal and health-care functions and its preparation method

field of invention

The invention relates to a salt-containing pharmaceutical composition and a preparation method thereof, in particular to a salt-containing Tibetan medicine composition with health care effects and a preparation method thereof.

Background technique

Long ago, European sailors had discovered that sea salt had specific effects on the skin. At sea, due to wind and sun, sailors' skin was prone to cracking and aging, but due to the cleansing and healing effects of sea salt, their skin Skin is always looking its best. The bath salt is based on this. On the basis of the main ingredient sea salt, other trace elements are added. Long-term use of this bath salt can deeply clean the skin, reduce inflammation, sterilize, remove excess oil and cuticle, etc., and repair unevenness Uneven epidermis and astringent large pores, used alone, can healthy skin, slimming and beautifying body. In many developed countries, especially the Nordic countries, people are used to washing their face and feet with deep-sea bath salt, which can promote metabolism, quickly heal small wounds, and remove dead skin. Experts are optimistic. The experience of the Nordic countries has proved that people who often suffer from colds and rheumatism can take a bath with bath salt, and their condition will definitely improve. Especially in cold winter, salt bath with bath salt can promote blood circulation and increase heat energy in the body. , to resist the invasion of wind and cold, and in summer it has the effect of cooling and relieving heat.

Tibetan medicine is a traditional medicine with complete principles, methods, prescriptions and medicines. It takes the theory of three causes as the theoretical core, the theory of five sources as the guiding ideology, and the medical theory system based on the physiological and pathological theories of seven substances, three filth, and viscera and meridians. Tibetan herbal bath is one of the unique external therapy methods that fully embodies its theoretical system and drug characteristics. On the basis of long-term accumulated medical knowledge, it is gradually combined with external drug therapy, and has developed into drug therapy after thousands of years of clinical practice. The branch has the characteristics of simplicity and wide application range.

Because the medicated bath directly acts on the diseased part, the effect is quick and painless. It not only has a therapeutic effect, but also has the advantages of cleaning, prevention, and health care. .

Contents of the invention

One object of the present invention is to disclose a pharmaceutical composition; another object of the present invention is to disclose a pharmaceutical composition with health-care effects; the third object of the present invention is to disclose a preparation method of the pharmaceutical composition.

The crude drug composition and proportioning of pharmaceutical composition of the present invention are as follows (by weight):

Salt: 1-150 parts by weight; Juniper: 1-3 parts by weight; Shuiba branch: 1-3 parts by weight; Rhododendron: 1-3 parts by weight; Artemisia grandis: 1-3 parts by weight;

The preferred proportioning ratio of the crude drug composition of the pharmaceutical composition of the present invention is (by weight):

Salt: 1 part by weight; Juniper: 1 part by weight; Cypress branch: 1 part by weight; Rhododendron japonica: 1 part by weight; Artemisia grandis: 1 part by weight;

The preferred proportioning ratio of the crude drug composition of the pharmaceutical composition of the present invention is (by weight):

Salt: 120 parts by weight; Juniper: 2 parts by weight; Cypress branches: 2 parts by weight; Rhododendron: 2 parts by weight; Artemisia grandis: 2 parts by weight;

The preferred proportioning ratio of the crude drug composition of the pharmaceutical composition of the present invention is (by weight):

1 part by weight of salt; 2 parts by weight of juniper; 2 parts by weight of cypress branch; 2 parts by weight of rhododendron;

The preferred proportioning ratio of the crude drug composition of the pharmaceutical composition of the present invention is (by weight):

Salt: 145 parts by weight; Juniper: 1 part by weight; Cypress branch: 1 part by weight; Rhododendron japonica: 1 part by weight; Artemisia grandis: 1 part by weight;

The preferred proportioning ratio of the crude drug composition of the pharmaceutical composition of the present invention is (by weight):

Salt: 15 parts by weight; Juniper: 3 parts by weight; Cypress branch: 1 part by weight; Rhododendron japonica: 3 parts by weight; Artemisia grandis: 1 part by weight;

The preferred proportioning ratio of the crude drug composition of the pharmaceutical composition of the present invention is (by weight):

Salt: 135 parts by weight; Juniper: 1 part by weight; Cypress branches: 3 parts by weight; Rhododendron japonica: 1 part by weight; Artemisia grandis: 3 parts by weight;

The above-mentioned pharmaceutical composition of the present invention can also add medicine:

1-10 parts by weight of ephedra; or 1-10 parts by weight of Eucommia ulmoides; or 0.05-10 parts by weight of turmeric; or 0.01-10 parts by weight of saffron; or 0.01-10 parts by weight of nutmeg; 1-5 parts by weight of Eucommia; or 0.05-5 parts by weight of turmeric; or 0.01-5 parts by weight of saffron; or 0.01-5 parts by weight of safflower or 0.01-5 parts by weight of nutmeg; or 0.01-5 parts by weight of Tibetan fennel; or 0.01-5 parts by weight of Sophora flavescens (including extracts); or 0.01-5 parts by weight of rock essence; or 0.01-5 parts by weight of Hanshuishi; or 0.01-5 parts by weight of Tribulus terrestris; or 0.01-5 parts by weight of musk deer dung; or 0.01-5 parts by weight of Alkaliflower; 0.01-5 parts by weight of Yumei or 0.01-5 parts by weight of 1 eucalyptus or 0.01-5 parts by weight of Gansong 1 or 0.01-5 parts by weight of Tibetan celery or 0.01-5 parts by weight of chrysanthemum or 1- 5 parts by weight or 1-5 parts by weight of Oxytropis or 1-5 parts by weight of Salicaceae plants, etc.

The preferred proportioning ratio of the drug added to the pharmaceutical composition of the present invention is (by weight):

1-3 parts by weight of ephedra; or 1-3 parts by weight of Eucommia ulmoides; or 0.01-0.05 parts by weight of turmeric; or 0.01-0.05 parts by weight of saffron; or 0.01-0.05 parts by weight of nutmeg;

The preferred proportioning ratio of the drug added to the pharmaceutical composition of the present invention is (by weight):

1 weight part of ephedra; or 2 weight parts of Eucommia; or 0.05 weight part of turmeric; or 0.03 weight part of saffron; or 0.01 weight part of nutmeg;

The preparation method of this pharmaceutical composition:

1. Powder the four medicinal materials of Juniper, Artemisia grandis, Shuibazhi, and Rhododendron into superfine powder according to the formula ratio, and mix the superfine powder, sea salt or mineral salt according to the ratio of 1-10:3-60 Evenly, the pharmaceutical composition is obtained.

2. Grind juniper cypress, Artemisia grandis, Shuiba branch, and rhododendron into coarse powder according to the formula ratio, fry in water for 2-3 times, and collect volatile oil at the same time, fry for 0.5-3 hours each time, and fry together Liquid, filtered, concentrated under reduced pressure to thick paste, freeze-dried, added volatile oil, crushed into fine powder (1) for later use; mix fine powder (1), sea salt or mineral salt according to the ratio of 1-30:3-60 Evenly, the pharmaceutical composition is obtained.

3. Grind juniper cypress, Artemisia grandis, Cedar twig, and rhododendron into coarse powder according to the formula ratio, fry in water for 2-3 times, collect volatile oil at the same time, fry for 0.5-3 hours each time, and fry together liquid, filtered, concentrated under reduced pressure to a thick paste, freeze-dried, added volatile oil, and pulverized into fine powder (1) for subsequent use; 1-10 parts by weight of natural medicine turmeric, saffron or nutmeg, powdered into coarse powder, and decocted Three times, collect the volatile oil at the same time, add 5-10 times the amount of water each time and fry for 20-100 minutes, the temperature is 80 ℃ ~ 95 ℃, filter, combine the filtrate, concentrate under reduced pressure to a thick paste, freeze-dry, add volatile oil, and grind into The fine powder (2) is used for standby; the fine powder (1), fine powder (2), sea salt or mineral salt are uniformly mixed according to the ratio of 1-30:1-30:10-60 to obtain the pharmaceutical composition.

4. Superfinely pulverize the four medicinal materials of juniper juniper, Artemisia grandis, Cedar twig and rhododendron according to the proportion of the formula, and pulverize them into superfine powder (1) for later use; the natural medicine turmeric or saffron or Nutmeg 1-10 parts by weight, powdered into coarse powder, decocted three times with water, and collected volatile oil at the same time, added 5-10 times the amount of water each time and decocted for 20-100 minutes at a temperature of 80°C to 95°C, filtered, combined the filtrates, and reduced Press and concentrate to a thick paste, freeze-dry, add volatile oil, and pulverize into fine powder (2) for later use; mix fine powder (1), fine powder (2), sea salt or mineral salt according to the ratio of 1-30:1-30:10- The ratio of 60 is mixed evenly to obtain the pharmaceutical composition.

The natural medicated bath salt prepared by the method of the invention can be used as a health-care medicated bath agent for diseases described in the combination of the functions and indications of natural medicines and the health-care functions of sea salt.

The natural medicated bath salt containing the active ingredients of natural medicinal plants prepared by the above method is soup powder.

In addition to sodium chloride, the main raw material salt also contains rich mineral components, such as magnesium chloride, calcium sulfate, magnesium sulfate and the like. Because the human body has a similar composition to seawater, and sea and lake salt is extracted from seawater and lake water, so absorbing sea salt in an appropriate amount will not have adverse effects on the human body, but will help maintain health. Using sea salt in your bath can do the following:

(1) Eliminate fatigue and make people feel refreshed.

(2) Supplement the salt and nutrients lost by the skin.

(3) Protect the skin from dryness and chapping.

(4) Promote blood circulation and keep skin healthy and energetic forever.

(5) Promote metabolism, prevent skin aging and relaxation.

(6) Make skin lubricated, soft and fragrant.

The advantage of method of the present invention is as follows:

1. The medicated bath salt product made by the method of the present invention is more stable than the bath salt made by the above-mentioned prior art, and has high quality and controllable quality, which is conducive to ensuring the curative effect. In the quality inspection, the detection standard can be set and can be used. Determination of drug content and detection of active ingredients to ensure the quality of medicated bath salts.

2. Since the method of the present invention adopts modern extraction and freeze-drying techniques, it not only effectively retains the active substances in the natural plant medicinal materials and the active ingredients of the medicinal materials, but also greatly improves the ratio of the crude drug components, so that the curative effect is better; The problem of transdermal absorption is solved, the effect is quicker, and the storage time of the medicine is greatly extended, which is easy to take and carry.

3. The natural medicated bath salt made by the method of the present invention does not need to add any chemically synthesized stabilizer, so it is safe and convenient to use, which not only saves the time wasted in health care for users, but also can take a bath and health care. . The production of the medicated bath salt of the present invention has realized industrialization, and the products are oriented to patients in thousands of households, and can also be transported long distances to enter the international market.

4. The production and processing of the present invention are simple and easy.

5. The product of the present invention is easy to carry and easy to use.

6. The product of the present invention has high crude drug content and quick onset of action.

7. The administration method of the present invention is simple and convenient.

The following experimental examples are used to further illustrate the present invention:

Experimental Example 1: Transdermal absorption experiment

1. Instruments and medicines, animals:

(1) Agilent8453E spectrophotometric system

(2) MSD-1200 Transdermal Absorption Apparatus and HC-288 Heating Water Cycle, Tianjin Silicon New Technology Co., Ltd.

(3) Isotonic phosphate buffer solution (PH=7.4); medicinal solution: Weigh 10 mg of the sample, put it in a 10 ml volumetric flask, dilute to the mark with deionized water, and shake well.

(4) Wister rats were taken, the abdominal hair was cut off, depilated with 5% sodium sulfide, and killed by dislocation, the abdominal skin was stripped, the subcutaneous fat was removed, washed repeatedly with normal saline, and stored at 4°C for future use.

(5) Take the cut mouse skin, place the cuticle upward on the rubber stopper, and place it between the upper and lower chambers of the Franz diffusion cell. The cuticle of the skin faces the supply chamber, and the dermis faces the receiving chamber. Fill the receiving chamber. Phosphate buffer solution (PH=7.4) preheated to 37+0.05°C, add 1ml/mg liquid medicine into the supply chamber, tighten and cover to prevent evaporation, and place in a constant temperature water bath at 37+0.05°C. Under continuous stirring (400rpm), absorb 0.5ml of the receiving solution at different time intervals, and add 0.5ml of the receiving solution after each sampling.

2. Test method: Juniper, rhododendron, and water cypress branches in the samples all contain flavonoids. Therefore, the content of total flavonoids in the sample was determined, and the content of total flavonoids was used as an index to reflect the content of the sample.

① Preparation of standard curve: Accurately weigh 200mg of rutin reference substance dried in vacuum at 120°C, put it in a 100.0ml volumetric flask, dissolve it with 70% ethanol to make 100.00ml, accurately weigh 10.0ml, add water to 100.0ml as the standard solution (0.2mg/ml). Precisely measure 0.5, 1.0, 1.5, 2.0, 2.5, 3.0ml of the standard solution into a 25ml volumetric flask, add water to 6ml, add 4ml of acetic acid-sodium acetate buffer solution with pH4.5, 4ml of 0.1mol/LAlCl3, add 70% Ethanol to the scale, mix well, use the corresponding solution without color developer as blank, measure the absorbance A at the wavelength of 410nm, and perform linear regression on the data to obtain the regression equation: y=0.004+0.8342A, r=0.9999.

②Determination method: Take 0.5ml of the test sample, put it in a Soxhlet extractor, add methanol to reflux and extract until the solvent is colorless, evaporate the solvent, add methanol to the residue to make it to 100.0ml, accurately measure two 1.0ml portions, and place them separately In a 25.0ml volumetric flask, add water to 6ml, add 4ml of acetic acid-sodium acetate buffer solution with pH 4.5, add 0.1mol/LAlCl34.0ml to one part, and add 70% ethanol to the other without the developer. 25.0ml, the front part is used as the test solution, and the back part is used as the blank solution, and the absorbance is measured at a wavelength of 410nm. The sample A reads the content of rutin in the test solution from the standard curve, calculates the sample concentration and Cumulative penetration.

3. Experimental results: plot the cumulative penetration per unit area (Q) of the drug against time (T) to obtain the transdermal absorption rate and permeability coefficient. (Table 1).

Table 1, the skin penetration rate and penetration system of each prescription Various prescriptions Transdermal rate (μg/cm ² h) Permeability coefficient (×10 ^3cm/h ) 1 0.044+0.004 2.2+0.08 2 0.038+0.004 1.8+0.08 control group 0.015+0.004 0.4+0.08

The matched group is Juniper: 1 weight part; Water Cypress branch: 1 weight part; Rhododendron lanceolata: 1 weight part; Artemisia grandis: 1 weight part; Ephedra: 1 weight part Ministry issued standard "1995 edition Tibetan medicine standard volume 1)

Sample 1: sea and lake salt: 10 parts by weight; juniper: 1 part by weight; water cypress branch: 2 parts by weight; rhododendron: 2 parts by weight; Artemisia grandis: 1 part by weight;

Sample 2: sea and lake salt: 10 parts by weight; juniper: 1 part by weight; water cypress branch: 1 part by weight; rhododendron: 1 part by weight; Artemisia grandis: 1 part by weight;

The skin penetration rate of the control group was the lowest, which was 0.015+0.004μg/cm-2.h-1. However, the skin penetration rates of samples 1 and 2 were increased by 2.933 and 2.533 times.

Experimental example 2: Stability investigation experiment:

1. Method

This test adopts accelerated test method, observes 18 months under the condition of 37-40 ℃ and relative humidity 75% to the Tibetan medicine composition in Experimental Example 1, each item is measured, the physical and chemical properties all do not change, each item The indicators are all within the range, and the results are shown in Table 2.

2. The name, model and manufacturer of the main inspection instruments and equipment:

Equipment Name Model Manufacturer

Moisture Rapid Meter SC69-02C Shanghai Second Ping Instrument Factory

Water-proof electric heating constant temperature incubator PYX-DHS-BS-II Shanghai Yuejin Medical Instrument Factory

Clean bench SW-CJ-IF Suzhou Antai Technology Co., Ltd.

Analytical balance 0Q-100, TJ.328D Shanghai Analytical Instrument Factory

3. Inspection items:

Properties: It is a bagged soaking bath agent, and the content is brown and white powder mixed evenly, with a delicate smell, salty, bitter and astringent taste.

Identification: (1) Take 1g of this product powder, add methanol 10ml, ultrasonically treat for 30 minutes, filter, and the filtrate is used as the test solution. Another 10 g of rhododendron as reference medicinal material was taken, and the reference medicinal material solution was prepared by the same method. According to the test of thin-layer chromatography (Appendix VI B, Chinese Pharmacopoeia, 2000 edition), draw 4 μl of each of the above two solutions, spot them on the same silica gel G thin-layer plate, and mix with chloroform-methanol-concentrated ammonia water (10:2:0.25) ) is the developing agent, the spreading distance is 10cm, take it out, and let it dry. View under UV light (365nm). In the chromatogram of the test product, there are fluorescent spots at the position corresponding to the chromatogram of the control medicinal material.

(2) Take 1 g of the powder of this product, add 10 ml of methanol, ultrasonicate for 30 minutes, filter, and the filtrate is used as the test solution. Take another 10 g of juniper leaf reference medicinal material, make the reference medicinal material solution in the same way, test according to thin-layer chromatography (Appendix VI B of Chinese Pharmacopoeia 2000 edition), draw 4 μl of each of the above two solutions, and spot on the same silica gel G thin layer respectively. On the board, use chloroform-methanol-concentrated ammonia water (10:2:0.25) as the developing agent, spread 10cm, take it out, and dry it in the air. View under UV light (365nm). In the chromatogram of the test product, there are fluorescent spots at the position corresponding to the chromatogram of the control medicinal material.

(3) Take 1 g of the powder of this product, add 10 ml of methanol, ultrasonicate for 30 minutes, filter, and the filtrate is used as the test solution. Another 10 g of Artemisia grandis reference medicinal material was taken, and the reference medicinal material solution was prepared in the same way. According to the thin-layer chromatography (Appendix VI B of the Chinese Pharmacopoeia 2000 edition), draw 6 μl of each of the above two solutions, respectively spot on the same silica gel G plate, and use chloroform-methanol-concentrated ammonia test solution (10:2.5:0.25 ) is the developing agent, the spreading distance is 10cm, take it out, and let it dry. View under UV light (365nm). In the chromatogram of the test product, there are fluorescent spots at the position corresponding to the chromatogram of the control medicinal material.

Check: Moisture, microbial limit inspection: should meet the relevant regulations under the powder item (Chinese Pharmacopoeia version one appendix I B in 2000).

4 Conclusion:

Experimental Example 1 was observed for 18 months under the conditions of 37-40°C and a relative humidity of 75%. Through the investigation of the character, moisture, and microbial limit, all indicators met the relevant requirements in the 2000 edition of the Chinese Pharmacopoeia (Part One). , through experiments, it shows that its quality is stable.

Table 2 Summary of Stability Experimental Research (1)

Sample: Same as transdermal test example 1:

Table 2 Summary of Stability Experimental Research (2)

Table 2 Summary of Stability Experimental Research (3)

Experimental Example 3: Comparative Experiment of Transdermal Absorption Kinetics

Series 1: sea and lake salt: 10 parts by weight; juniper: 1 part by weight; water cypress branch: 2 parts by weight; rhododendron: 2 parts by weight; Artemisia grandis: 1 part by weight;

Series 2: sea and lake salt: 10 parts by weight; juniper: 1 part by weight; cypress branch: 1 part by weight; rhododendron: 1 part by weight; Artemisia grandis: 1 part by weight;

Series 3: Juniper: 1 part by weight; Water cypress branch: 1 part by weight; Rhododendron: 1 part by weight; Artemisia grandis: 1 part by weight; Standards issued by the Ministry) 1995 Edition Tibetan Medicine Standards Volume 1)

Same as the above transdermal absorption experiment: the cumulative permeation amount per unit area (Q) of the drug is plotted against time (T) to obtain the transdermal absorption kinetics curve (as shown in Figure 1).

Description of drawings:

Figure 1: Kinetic curve of transdermal absorption

Example 1:

Powder Tibetan medicine (100kg juniper, 100kg Artemisia grandis, 100kg water cypress branch, 100kg strong rhododendron) and above four kinds of medicinal materials, grind them into coarse powder, fry in water three times, and collect volatile oil at the same time, fry for 1 hour for the first time, and fry for two Fry each time for 0.5 hours, combine the decoction, filter, concentrate under reduced pressure to a thick paste, freeze-dry, add volatile oil, and grind into fine powder (1) for later use; 1 kg of natural medicine turmeric, powder into coarse powder, add water and fry three times , and collect volatile oil at the same time, add 10 times the amount of water for 90 minutes for the first time, filter, add 6 times the amount of water for 60 minutes, filter, add 6 times the amount of water for 30 minutes, filter, Combine the filtrates, concentrate under reduced pressure to a thick paste, freeze-dry, add volatile oil, and pulverize into fine powder (2) for later use; mix fine powder (1), fine powder (2), and sea lake salt in a ratio of 10:10:10 Mix evenly, sub-package to make 100g/bottle of natural medicated bath salt that is easy to use and easy to carry (and adapt to the lifestyle of modern people). The natural medicated bath salt has the health care effect of expelling wind and dehumidification.

Example 2:

Powder Tibetan medicine (100kg juniper, 100kg Artemisia grandis, 100kg water cypress branch, 100kg strong rhododendron) and above four kinds of medicinal materials, grind them into coarse powder, fry in water three times, and collect volatile oil at the same time, fry for 1 hour for the first time, and fry for two Fry each time for 0.5 hours, combine the decoction, filter, concentrate under reduced pressure to a thick paste, freeze-dry, add volatile oil, and pulverize into fine powder (1) for later use; grind 1 kg of safflower into coarse powder, add water and decoct three times, For the first time, add 10 times the amount of water and fry for 90 minutes at a temperature of 80°C to 95°C, filter, add 6 times of the amount for the second time and fry for 60 minutes at a temperature of 80°C to 95°C, filter, and add 6 times for the third time Measure water and decoct for 30 minutes at a temperature of 80°C to 95°C, filter, combine the filtrates, concentrate under reduced pressure to a thick paste, freeze-dry, and pulverize into fine powder (2) for later use. Fine powder (1), fine powder (2) ), sea salt according to the ratio of 1:1:60, mixed evenly, sub-packed to make 100g/bottle of natural medicated bath salt which is easy to use and easy to carry (and adapt to the lifestyle of modern people). The natural medicated bath salt has the health care effect of beautifying and losing weight.

Example 3:

Powder 100kg of Juniper, 100kg of Artemisia grandis, 100kg of Shuibazhi, and 100kg of Rhododendron, and grind them into coarse powder, decoct in water three times, and collect volatile oil at the same time, decoct for 1 hour for the first time, and decoct for 0.5 hours, combined decoction, filtered, concentrated under reduced pressure to thick paste, freeze-dried, added volatile oil, ground into fine powder (1) for subsequent use, natural medicine (Tibetan fennel 1kg, nutmeg 1kg), powdered into coarse powder, Add water to decoct three times, and collect volatile oil at the same time. For the first time, add 10 times the amount of water to decoct for 90 minutes at a temperature of 80 ° C to 95 ° C. After the third time, add 6 times the amount of water and decoct for 30 minutes at a temperature of 80°C to 95°C, filter, combine the filtrates, concentrate under reduced pressure to a thick paste, freeze-dry, add volatile oil, and grind into fine powder (2) for later use. Mix the fine powder (1), fine powder (2), and sea salt according to the ratio of 1-30:1-30:10-60, and pack them into 100g/bottles, which are easy to use and carry (and adapt to the life of modern people) way) natural medicated bath salt. The natural medicated bath salt has the health care effect of calming the nerves and helping sleep.

Example 4:

Grind 33kg of Juniper, 100kg of Artemisia grandis, 33kg of Shuibazhi, and 100kg of Rhododendron 100kg into coarse powder, decoct in water for 3 times, and collect volatile oil at the same time, decoct for 1 hour for the first time, and decoct for 0.5 hours, combined decoction, filtered, concentrated under reduced pressure to a thick paste, freeze-dried, added volatile oil, crushed into fine powder (1) for later use; fine powder (1), sea salt according to the ratio of 1-30:3-60 Mix evenly, sub-package to make 100g/bottle of natural medicated bath salt that is easy to use and easy to carry (and adapt to the lifestyle of modern people). The natural medicated bath salt has the health care effect of beautifying and losing weight.

Example 5:

Grind 100kg of Juniper, 33kg of Artemisia grandis, 100kg of Shuicypress branch, 33kg of Rhododendron lanceolata and 33kg of four herbs into coarse powder, decoct in water for 3 times, and collect volatile oil at the same time, decoct for 1 hour for the first time, and decoct for 0.5 hours, combined the decoction, filtered, concentrated under reduced pressure to a thick paste, freeze-dried, added volatile oil, and pulverized into fine powder (1) for later use; 3kg of natural medicine saffron, powdered into coarse powder, decocted three times with water, and collected For volatile oil, add 10 times the amount of water for the first time and decoct for 90 minutes at a temperature of 80°C to 95°C; Decoct 6 times the amount of water for 30 minutes at a temperature of 80°C to 95°C, filter, combine the filtrates, concentrate under reduced pressure to a thick paste, freeze-dry, add volatile oil, and grind into fine powder (2) for later use; fine powder (1) , fine powder (2), and sea salt are mixed evenly according to the ratio of 1-30:1-30:10-60, and then packed into 100g/bottle, which is convenient to use and easy to carry (and adapts to the lifestyle of modern people) natural medicated bath salt . The natural medicated bath salt has the health care effect of beautifying and losing weight.

Embodiment 6:

Powder 100g of Juniper, 100g of Artemisia dassicae, 200g of Shuibaizhi, 200g of Rhododendron lanceolata into superfine powder according to the proportion of the formula, and mix superfine powder, rock essence and Daqing salt according to the ratio of 1-10:1 - mix uniformly at a ratio of 10:3-60 to obtain the pharmaceutical composition.

Embodiment 7:

Powder 50g of Juniper, 100g of Artemisia grandis, 150g of Shuibaizhi, 100g of Rhododendron, four medicinal materials into superfine powder according to the formula ratio, and mix superfine powder, cold water stone, sea and lake salt according to the ratio of 1-10:2 - mix uniformly in the ratio of 8:3-60 to obtain the pharmaceutical composition.

Embodiment 8:

Powder 100g of Juniper, 100g of Artemisia grandis, 200g of Shuibaizhi, 200g of Rhododendron japonica into ultra-fine powder according to the formula ratio, and mix ultra-fine powder, cold water stone, sea and lake salt according to the ratio of 1-10:2 - mix uniformly in the ratio of 8:3-60 to obtain the pharmaceutical composition.

Embodiment 9:

Powder 100g of Juniper, 150g of Artemisia Daziensis, 150g of Shuibai Zhi, 200g of Rhododendron Rhododendron into ultra-fine powder according to the formula ratio, and mix ultra-fine powder, cold water stone, and large green salt according to the ratio of 1-10:2 - mix uniformly in the ratio of 8:3-60 to obtain the pharmaceutical composition.

Example 10:

Powder 100g of Juniper, 100g of Artemisia grandis, 200g of Shuibazhi, 150g of Rhododendron, and powder them into superfine powder according to the proportion of the formula. The ratio of 10:2-8:2-8:2-8:3-60 is uniformly mixed to obtain the pharmaceutical composition.

Example 11:

Powder 100g of Juniper, 100g of Artemisia grandis, 200g of Shuibazhi, and 200g of Rhododendron japonica into ultra-fine powder according to the formula ratio, and mix ultra-fine powder, Tribulus terrestris, sea and lake salt according to the ratio of 1-10:1- The ratio of 5:3-60 is uniformly mixed to obtain the pharmaceutical composition.

Example 12:

Powder 150g of Juniper, 150g of Artemisia grandis, 200g of Shuibaizhi, 200g of Rhododendron japonica into ultra-fine powder according to the formula ratio, and mix ultra-fine powder, musk deer manure, and large green salt according to the ratio of 1-10:1 - mix uniformly in the ratio of 3:3-60 to obtain the pharmaceutical composition.

Example 13:

Powder 100g of Juniper, 100g of Artemisia grandis, 200g of Shuibazhi, and 200g of Rhododendron japonica into ultrafine powder according to the formula ratio, and mix ultrafine powder, alkali flower, sea and lake salt according to the ratio of 1-10:0.05 - mix uniformly at a ratio of 1:3-60 to obtain the pharmaceutical composition.

Example 14:

Powder 100g juniper, 100g Artemisia grandis, 200g water cypress branch, 200g strong rhododendron, four flavors of medicinal materials into ultrafine powder according to the formula ratio, and mix ultrafine powder, plateau ranunculus, sea and lake salt according to the ratio of 1-10:2 - mix uniformly in the ratio of 8:3-60 to obtain the pharmaceutical composition.

Example 15:

Powder 100g of Juniper, 100g of Artemisia grandis, 200g of Shuibazhi, and 200g of Rhododendron japonica into superfine powder according to the formula ratio, and mix superfine powder, clematis, sea and lake salt according to 1-10: The ratio of 1-10:3-60 is uniformly mixed to obtain the pharmaceutical composition.

Example 16:

Powder 150g of Juniper, 100g of Artemisia grandis, 150g of Shuibazhi, 200g of Rhododendron lanceolata into superfine powder according to the proportion of the formula, and mix superfine powder, grass jade plum and Daqing salt according to 1-10: The ratio of 1-10:3-60 is uniformly mixed to obtain the pharmaceutical composition.

Example 17:

Powder 100g of Juniper, 100g of Artemisia grandis, 150g of Shuibazhi, and 200g of Rhododendron lanceolata into ultra-fine powder according to the formula ratio, and mix ultra-fine powder, lovage, and Daqing salt according to the ratio of 1-10:1- The ratio of 10:3-60 is uniformly mixed to obtain the pharmaceutical composition.

Example 18:

Powder 100g of Juniper, 100g of Artemisia grandis, 200g of Shuibazhi, 150g of Rhododendron, four medicinal materials into ultrafine powder according to the formula ratio, and mix ultrafine powder, Gansong, sea and lake salt according to the ratio of 1-10:2 - mix uniformly in the ratio of 8:3-60 to obtain the pharmaceutical composition.

Example 19:

Powder 100g of Juniper, 100g of Artemisia grandis, 150g of Shuibazhi, 200g of Rhododendron, four medicinal materials into superfine powder according to the proportion of the formula. : 1-10: 3-60 and mixed uniformly to obtain the pharmaceutical composition.

Example 20:

Powder 150g of Juniper, 150g of Artemisia grandis, 200g of Shuibazhi, 200g of Rhododendron lanceolata into ultra-fine powder according to the formula ratio, and mix ultra-fine powder, A. The ratio of 1-10:3-60 is uniformly mixed to obtain the pharmaceutical composition.

Example 21:

Powder 100g of Juniper, 100g of Artemisia grandis, 200g of Shuibaizhi, 200g of Rhododendron japonica into ultra-fine powder according to the formula ratio, and mix ultra-fine powder, cold water stone, sea and lake salt according to the ratio of 1-10:2 - mix uniformly in the ratio of 8:3-60 to obtain the pharmaceutical composition.

Example 22:

Powder 100g of Juniper, 100g of Artemisia grandis, 200g of Shuibaizhi, and 200g of Rhododendron japonica into ultra-fine powder according to the formula ratio, and mix the ultra-fine powder, Duyiwei, sea and lake salt according to the ratio of 1-10:1 - mix uniformly at a ratio of 10:3-60 to obtain the pharmaceutical composition.

Example 23:

Powder 100g of Juniper, 100g of Artemisia grandis, 200g of Shuibazhi, and 200g of Rhododendron japonica into ultra-fine powder according to the formula ratio, and mix ultra-fine powder, Oxytropis, sea and lake salt according to the ratio of 1-10:1 - mix uniformly at a ratio of 10:3-60 to obtain the pharmaceutical composition.

Example 24:

Powder 100g of Juniper, 100g of Artemisia grandis, 200g of Shuibazhi, 200g of Rhododendron lanceolata into ultra-fine powder according to the formula ratio, and mix ultra-fine powder, mountain willow, sea and lake salt according to 1-10:1 - mix uniformly at a ratio of 10:3-60 to obtain the pharmaceutical composition.

Example 25:

Powder 100g of Juniper, 100g of Artemisia grandis, 200g of Shuibaizhi, 200g of Rhododendron, four medicinal materials into ultrafine powder according to the formula ratio, and mix ultrafine powder, aspen, sea and lake salt according to 1-10:1 - mix uniformly at a ratio of 10:3-60 to obtain the pharmaceutical composition.

Claims (24)

1, a kind of pharmaceutical composition is characterized in that this pharmaceutical composition made by following raw material medicaments:

Sea salt, sea lake salt or halite 1-150 weight portion Juniperus oxycedrus 1-3 weight portion

Cacumen Myricariae Germanicae 1-3 weight portion Rhododendron 1-3 weight portion Artemisia sieversiana Willd. 1-3 weight portion.

2, pharmaceutical composition as claimed in claim 1 is characterized in that this pharmaceutical composition made by following raw material medicaments:

Sea salt, sea lake salt or halite 1 weight portion Juniperus oxycedrus 2 weight portions

Cacumen Myricariae Germanicae 2 weight portion Rhododendrons 2 weight portion Artemisia sieversiana Willd. 2 weight portions.

3, pharmaceutical composition as claimed in claim 1 is characterized in that this pharmaceutical composition made by following raw material medicaments:

Sea salt, sea lake salt or halite 120 weight portion Juniperus oxycedruss 2 weight portions

Cacumen Myricariae Germanicae 2 weight portion Rhododendrons 2 weight portion Artemisia sieversiana Willd. 2 weight portions.

4, pharmaceutical composition as claimed in claim 1 is characterized in that this pharmaceutical composition made by following raw material medicaments:

Sea salt, sea lake salt or halite 145 weight portion Juniperus oxycedruss 1 weight portion

Cacumen Myricariae Germanicae 1 weight portion Rhododendron 1 weight portion Artemisia sieversiana Willd. 1 weight portion.

5, pharmaceutical composition as claimed in claim 1 is characterized in that this pharmaceutical composition made by following raw material medicaments:

Sea salt, sea lake salt or halite 15 weight portion Juniperus oxycedruss 3 weight portions

Cacumen Myricariae Germanicae 1 weight portion Rhododendron 3 weight portion Artemisia sieversiana Willd. 1 weight portion.

6, pharmaceutical composition as claimed in claim 1 is characterized in that this pharmaceutical composition made by following raw material medicaments

Sea salt, sea lake salt or halite 135 weight portion Juniperus oxycedruss 1 weight portion

Cacumen Myricariae Germanicae 3 weight portion Rhododendrons 1 weight portion Artemisia sieversiana Willd. 3 weight portions.

7,, it is characterized in that this pharmaceutical composition adds following crude drug as claim 1,2,3,4,5 or 6 described pharmaceutical compositions:

Herba Ephedrae 1-5 weight portion; Or add Cortex Eucommiae 1-5 weight portion; Or Rhizoma Curcumae Longae 0.05-5 weight portion; Or Stigma Croci 0.01-5 weight portion; Or Flos Carthami 0.01-5 weight portion or Semen Myristicae 0.01-5 weight portion; Or Fructus cari carvi 0.01-5 weight portion; Or Radix Sophorae Flavescentis 0.01-5 weight portion; Or YANJING 0.01-5 weight portion; Or Mirabilitum crystallina 0.01-5 weight portion; Or Olibanum 0.01-5 weight portion, Semen Cassiae 0.01-5 weight portion, Semen seu folium abelmoschi moschati 0.01-5 weight portion; Or Fructus Tribuli 0.01-5 weight portion; Or Moschus 0.01-5 weight portion; Or trona 0.01-5 weight portion; Or Ranunculus tanguticus (Maxim) Orcz. 0.01-5 weight portion or Radix clematidis floridae 0.01-5 weight portion or Herba Veronicastri Sibirici 0.01-5 weight portion or Radix Angelicae Pubescentis 0.01-5 weight portion or Radix Et Rhizoma Nardostachyos 0.01-5 weight portion or Herba pleurospermi thomsonii 0.01-5 weight portion or Grow thickly sub-chrysanthemum 0.01-5 weight portion or Radix Lamiophlomidis Rotatae 1-5 weight portion or Herba Oxytropis Kansuensis 1-5 weight portion or Salicaceae plant 1-5 weight portion.

8,, it is characterized in that this pharmaceutical composition adds following crude drug as claim 1,2,3,4,5 or 6 described pharmaceutical compositions:

Herba Ephedrae 1-3 weight portion; Or add Cortex Eucommiae 1-3 weight portion; Or Rhizoma Curcumae Longae 0.05-1 weight portion; Or Stigma Croci 0.01-0.05 weight portion or Flos Carthami 0.01-0.05 weight portion; Or Semen Myristicae 0.01-0.05 weight portion or Fructus cari carvi 0.01-0.05 weight portion or YANJING 0.01-0.05 weight portion or Mirabilitum crystallina 0.01-0.05 weight portion or Olibanum 0.01-0.05 weight portion, Semen Cassiae 0.01-0.05 weight portion, Semen seu folium abelmoschi moschati 0.01-0.05 weight portion or Fructus Tribuli 0.01-0.05 weight portion or Moschus 0.01-0.05 weight portion or trona 0.01-0.05 weight portion, or Ranunculus tanguticus (Maxim) Orcz. 0.01-0.05 weight portion or Radix clematidis floridae 0.01-0.05 weight portion or Herba Veronicastri Sibirici 0.01-0.05 weight portion or Radix Angelicae Pubescentis 0.01-0.05 weight portion or Radix Et Rhizoma Nardostachyos 0.01-0.05 weight portion or Herba pleurospermi thomsonii 0.01-0.05 weight portion or Grow thickly sub-chrysanthemum 0.01-0.05 weight portion or Radix Lamiophlomidis Rotatae 1-3 weight portion or Herba Oxytropis Kansuensis 1-3 weight portion or Salicaceae plant 1-3 weight portion.

9,, it is characterized in that this pharmaceutical composition adds following crude drug as claim 1,2,3,4,5 or 6 described pharmaceutical compositions:

Herba Ephedrae 2 weight portions; Or add the Cortex Eucommiae 2 weight portions; Or Rhizoma Curcumae Longae 2 weight portions; Or Stigma Croci 0.03 weight portion; Or Flos Carthami 2 weight portions or Semen Myristicae 3 weight portions or Fructus cari carvi 3 weight portions or Herba Oxytropis Kansuensis 2 weight portions or Salicaceae plant 2 weight portions.

10, preparation of drug combination method as claimed in claim 7 is characterized in that this method is:

With Juniperus oxycedrus, Artemisia sieversiana Willd., Cacumen Myricariae Germanicae, Rhododendron four Chinese medicine material, become coarse powder by the formula proportion powder, decocting 2-3 time is collected volatile oil simultaneously, fried in shallow oil 0.5-3 hour, collecting decoction filters, and is evaporated to the thick paste shape at every turn, lyophilization adds volatile oil, and it is standby to be ground into fine powder a; With crude drug Rhizoma Curcumae Longae or Flos Carthami or Semen Myristicae or Fructus cari carvi, powder becomes coarse powder, adds decocting three times, collects volatile oil simultaneously, add 5-10 times of water gaging fried in shallow oil 20-100 minute at every turn, 80 ℃～100 ℃ of temperature filter merging filtrate, be evaporated to the thick paste shape, lyophilization adds volatile oil, and it is standby to be ground into fine powder b; Fine powder a, fine powder b, sea salt is even according to the mixed of 1-30: 1-30: 10-60, this pharmaceutical composition.

11, preparation of drug combination method as claimed in claim 8, it is characterized in that this method is:, become coarse powder by the formula proportion powder, decocting 2-3 time with Juniperus oxycedrus, Artemisia sieversiana Willd., Cacumen Myricariae Germanicae, Rhododendron four Chinese medicine material, collect volatile oil simultaneously, fried in shallow oil 0.5-3 hour, collecting decoction filters at every turn, be evaporated to the thick paste shape, lyophilization adds volatile oil, and it is standby to be ground into fine powder a; With crude drug Rhizoma Curcumae Longae or Flos Carthami or Semen Myristicae or Fructus cari carvi, powder becomes coarse powder, adds decocting three times, collects volatile oil simultaneously, add 5-10 times of water gaging fried in shallow oil 20-100 minute at every turn, 80 ℃～100 ℃ of temperature filter merging filtrate, be evaporated to the thick paste shape, lyophilization adds volatile oil, and it is standby to be ground into fine powder b; Fine powder a, fine powder b, sea salt is even according to the mixed of 1-30: 1-30: 10-60, this pharmaceutical composition.

12, preparation of drug combination method as claimed in claim 9, it is characterized in that this method is:, become coarse powder by the formula proportion powder, decocting 2-3 time with Juniperus oxycedrus, Artemisia sieversiana Willd., Cacumen Myricariae Germanicae, Rhododendron four Chinese medicine material, collect volatile oil simultaneously, fried in shallow oil 0.5-3 hour, collecting decoction filters at every turn, be evaporated to the thick paste shape, lyophilization adds volatile oil, and it is standby to be ground into fine powder a; With crude drug Rhizoma Curcumae Longae or Flos Carthami or Semen Myristicae or Fructus cari carvi, powder becomes coarse powder, adds decocting three times, collects volatile oil simultaneously, add 5-10 times of water gaging fried in shallow oil 20-100 minute at every turn, 80 ℃～100 ℃ of temperature filter merging filtrate, be evaporated to the thick paste shape, lyophilization adds volatile oil, and it is standby to be ground into fine powder b; Fine powder a, fine powder b, sea salt is even according to the mixed of 1-30: 1-30: 10-60, this pharmaceutical composition.

13, as claim 10,11 or 12 described preparation of drug combination methods, it is characterized in that this method is:

With Juniperus oxycedrus, Artemisia sieversiana Willd., Cacumen Myricariae Germanicae, Rhododendron four Chinese medicine material, become coarse powder by the formula proportion powder, decocting three times is collected volatile oil simultaneously, fried in shallow oil 1 hour for the first time, respectively fried in shallow oil 0.5 hour for twice the back, and collecting decoction filters, be evaporated to the thick paste shape, lyophilization adds volatile oil, and it is standby to be ground into fine powder a; The crude drug curcuma powder is become coarse powder, add decocting three times, collect volatile oil simultaneously, for the first time add 10 times of water gagings and fried in shallow oil 90 minutes, filter, add 6 times of water gagings for the second time and fried in shallow oil 60 minutes, filter, add 6 times of water gagings for the third time and fried in shallow oil 30 minutes, filter merging filtrate, be evaporated to the thick paste shape, lyophilization adds volatile oil, and it is standby to be ground into fine powder b; Fine powder a, fine powder b, sea lake salt is even according to the mixed of 10-30: 1-30: 14-60, and the crude drug bath salt is made in packing.

14, as claim 1,2,3,4,5 or 6 described preparation of drug combination methods, it is characterized in that this method is:

With Juniperus oxycedrus, Artemisia sieversiana Willd., Cacumen Myricariae Germanicae, Rhododendron four Chinese medicine material, become coarse powder by the formula proportion powder, decocting 2-3 time is collected volatile oil simultaneously, fried in shallow oil 0.5-3 hour, collecting decoction filters, and is evaporated to the thick paste shape at every turn, lyophilization adds volatile oil, and it is standby to be ground into fine powder a; Fine powder a, halite is even according to the mixed of 1-30: 3-60, this pharmaceutical composition.

15, preparation of drug combination method as claimed in claim 14 is characterized in that this method is:

With Juniperus oxycedrus, Artemisia sieversiana Willd., Cacumen Myricariae Germanicae, Rhododendron four Chinese medicine material, become coarse powder by the formula proportion powder, decocting 3 times is collected volatile oil simultaneously, fried in shallow oil 1 hour for the first time, respectively fried in shallow oil 0.5 hour for twice the back, and collecting decoction filters, be evaporated to the thick paste shape, lyophilization adds volatile oil, and it is standby to be ground into fine powder a; Fine powder a, halite is even according to the mixed of 1-30: 3-60, this pharmaceutical composition.

16, preparation of drug combination method as claimed in claim 7 is characterized in that this method is:

With Juniperus oxycedrus, Artemisia sieversiana Willd., Cacumen Myricariae Germanicae, Rhododendron four Chinese medicine material, be broken into thick micropowders by the formula proportion superfine powder, it is standby to be ground into micropowders a; With crude drug Rhizoma Curcumae Longae or Flos Carthami or Semen Myristicae, powder becomes coarse powder, adds decocting three times, collects volatile oil simultaneously, add 5-10 times of water gaging at every turn and fried in shallow oil 20-100 minute, 80 ℃～95 ℃ of temperature filter merging filtrate, be evaporated to the thick paste shape, lyophilization adds volatile oil, and it is standby to be ground into fine powder b; Fine powder a, fine powder b, sea salt is even according to the mixed of 1-30: 1-30: 10-60, this pharmaceutical composition.

17, preparation of drug combination method as claimed in claim 8 is characterized in that this method is: with Juniperus oxycedrus, Artemisia sieversiana Willd., Cacumen Myricariae Germanicae, Rhododendron four Chinese medicine material, be broken into thick micropowders by the formula proportion superfine powder, it is standby to be ground into micropowders a; With crude drug Rhizoma Curcumae Longae or Flos Carthami or Semen Myristicae, powder becomes coarse powder, adds decocting three times, collects volatile oil simultaneously, add 5-10 times of water gaging at every turn and fried in shallow oil 20-100 minute, 80 ℃～95 ℃ of temperature filter merging filtrate, be evaporated to the thick paste shape, lyophilization adds volatile oil, and it is standby to be ground into fine powder b; Fine powder a, fine powder b, sea salt is even according to the mixed of 1-30: 1-30: 10-60, this pharmaceutical composition.

18, preparation of drug combination method as claimed in claim 9 is characterized in that this method is: with Juniperus oxycedrus, Artemisia sieversiana Willd., Cacumen Myricariae Germanicae, Rhododendron four Chinese medicine material, be broken into thick micropowders by the formula proportion superfine powder, it is standby to be ground into micropowders a; With crude drug Rhizoma Curcumae Longae or Flos Carthami or Semen Myristicae, powder becomes coarse powder, adds decocting three times, collects volatile oil simultaneously, add 5-10 times of water gaging at every turn and fried in shallow oil 20-100 minute, 80 ℃～95 ℃ of temperature filter merging filtrate, be evaporated to the thick paste shape, lyophilization adds volatile oil, and it is standby to be ground into fine powder b; Fine powder a, fine powder b, sea salt is even according to the mixed of 1-30: 1-30: 10-60, this pharmaceutical composition.

19, as claim 16,17 or 18 described preparation of drug combination methods, it is characterized in that this method is:

With Juniperus oxycedrus, Artemisia sieversiana Willd., Cacumen Myricariae Germanicae, Rhododendron four Chinese medicine material, be broken into thick micropowders by the formula proportion superfine powder, it is standby to be ground into micropowders a; The crude drug Flos Carthami powder is become coarse powder, add decocting three times, collect volatile oil simultaneously, for the first time add 10 times of water gagings and fried in shallow oil 90 minutes, filter, add 6 times of water gagings for the second time and fried in shallow oil 60 minutes, filter, add 6 times of water gagings for the third time and fried in shallow oil 30 minutes, filter merging filtrate, be evaporated to the thick paste shape, lyophilization adds volatile oil, and it is standby to be ground into fine powder b; Fine powder a, fine powder b, sea salt is even according to the mixed of 1-30: 1-30: 10-60, this pharmaceutical composition.

20, as claim 1,2,3,4,5 or 6 described preparation of drug combination methods, it is characterized in that this method is:

With Juniperus oxycedrus, Artemisia sieversiana Willd., Cacumen Myricariae Germanicae, Rhododendron four Chinese medicine material, become micropowders by the formula proportion powder, micropowders, sea salt is even according to the mixed of 1-10: 3-60, this pharmaceutical composition.

21, as claim 1,2,3,4,5 or 6 described pharmaceutical compositions have allaying tiredness in preparation, replenish the skin nutrient, the protection skin, increase immunity, dispel rheumatism, blood circulation promoting or the Transdermal absorption medicine of the effect of enhancing metabolism in application.

22, pharmaceutical composition as claimed in claim 7 have allaying tiredness in preparation, replenish the skin nutrient, the protection skin, increase immunity, dispel rheumatism, blood circulation promoting or the Transdermal absorption medicine of the effect of enhancing metabolism in application.

23, pharmaceutical composition as claimed in claim 8 have allaying tiredness in preparation, replenish the skin nutrient, the protection skin, increase immunity, dispel rheumatism, blood circulation promoting or the Transdermal absorption medicine of the effect of enhancing metabolism in application.

24, pharmaceutical composition as claimed in claim 9 have allaying tiredness in preparation, replenish the skin nutrient, the protection skin, increase immunity, dispel rheumatism, blood circulation promoting or the Transdermal absorption medicine of the effect of enhancing metabolism in application.

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