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CL2023002723A1 - Nuevo agente de contraste para utilizar en imágenes por resonancia magnética - Google Patents

Nuevo agente de contraste para utilizar en imágenes por resonancia magnética

Info

Publication number
CL2023002723A1
CL2023002723A1 CL2023002723A CL2023002723A CL2023002723A1 CL 2023002723 A1 CL2023002723 A1 CL 2023002723A1 CL 2023002723 A CL2023002723 A CL 2023002723A CL 2023002723 A CL2023002723 A CL 2023002723A CL 2023002723 A1 CL2023002723 A1 CL 2023002723A1
Authority
CL
Chile
Prior art keywords
magnetic resonance
contrast agent
resonance imaging
new contrast
compounds
Prior art date
Application number
CL2023002723A
Other languages
English (en)
Inventor
Thomas Brumby
Markus Berger
Simon Anthony Herbert
Thomas Frenzel
Jessica Lohrke
Olaf Panknin
Claudia Green
Gregor Jost
Hubertus Pietsch
Sven Wittrock
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of CL2023002723A1 publication Critical patent/CL2023002723A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A61K49/108—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA the metal complex being Gd-DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic Table without C-Metal linkages

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención se relaciona con una nueva clase de compuestos de fórmula general (I), con los complejos de quelato de Gd3+ de los mismos, con métodos para preparar dichos compuestos, y con el uso de dichos compuestos como agentes de contraste para IRM.
CL2023002723A 2021-03-15 2023-09-13 Nuevo agente de contraste para utilizar en imágenes por resonancia magnética CL2023002723A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP21162650.2A EP4059925A1 (en) 2021-03-15 2021-03-15 New contrast agent for use in magnetic resonance imaging

Publications (1)

Publication Number Publication Date
CL2023002723A1 true CL2023002723A1 (es) 2024-01-26

Family

ID=74874752

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2023002723A CL2023002723A1 (es) 2021-03-15 2023-09-13 Nuevo agente de contraste para utilizar en imágenes por resonancia magnética

Country Status (20)

Country Link
US (1) US20240182431A1 (es)
EP (2) EP4059925A1 (es)
JP (1) JP2024512459A (es)
KR (1) KR20230157412A (es)
CN (1) CN116981658A (es)
AR (1) AR126325A1 (es)
AU (1) AU2022236333A1 (es)
BR (1) BR112023017197A2 (es)
CA (1) CA3213386A1 (es)
CL (1) CL2023002723A1 (es)
CO (1) CO2023012137A2 (es)
CR (1) CR20230433A (es)
DO (1) DOP2023000185A (es)
EC (1) ECSP23070062A (es)
GE (1) GEP20257722B (es)
IL (1) IL305294A (es)
MX (1) MX2023010737A (es)
PE (1) PE20240821A1 (es)
TW (1) TW202302543A (es)
WO (1) WO2022194777A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4210069A1 (en) * 2022-01-11 2023-07-12 Bayer Aktiengesellschaft Synthetic contrast-enhanced ct images
WO2024046831A1 (de) 2022-08-30 2024-03-07 Bayer Aktiengesellschaft Erzeugen von synthetischen radiologischen aufnahmen
WO2024046833A1 (de) 2022-08-30 2024-03-07 Bayer Aktiengesellschaft Erzeugen von synthetischen radiologischen aufnahmen
WO2024046832A1 (de) 2022-08-30 2024-03-07 Bayer Aktiengesellschaft Erzeugen von synthetischen radiologischen aufnahmen
CN119816744A (zh) 2022-09-05 2025-04-11 拜耳公司 生成人工对比度增强的放射图像
EP4336204A1 (de) 2022-09-07 2024-03-13 Bayer AG Beschleunigen von mrt-untersuchungen der leber
EP4335462A1 (en) * 2022-09-09 2024-03-13 Bayer AG Contrast agents for use in diagnostic computed tomography imaging
WO2024083466A1 (de) 2022-10-17 2024-04-25 Bayer Aktiengesellschaft Automatisches analysieren von radiologischen aufnahmen
CN116444428A (zh) * 2022-10-25 2023-07-18 无锡贝塔医药科技有限公司 一种吡啶环3-位引入c-14标记的乙醇基团的方法
EP4369285A1 (de) 2022-11-12 2024-05-15 Bayer AG Erzeugung von künstlichen kontrastmittelverstärkten radiologischen aufnahmen
EP4369353A1 (de) 2022-11-12 2024-05-15 Bayer Aktiengesellschaft Erzeugung von künstlichen kontrastmittelverstärkten radiologischen aufnahmen
EP4375919A1 (de) 2022-11-25 2024-05-29 Bayer AG Erzeugen von kontrastverstärkten synthetischen radiologischen aufnahmen
EP4471710A1 (de) 2023-05-30 2024-12-04 Bayer AG Erkennen von artefakten in synthetischen medizinischen aufnahmen
US20240404255A1 (en) 2023-06-05 2024-12-05 Bayer Aktiengesellschaft Generation of artificial contrast-enhanced radiological images
EP4475137A1 (de) 2023-06-05 2024-12-11 Bayer AG Erzeugen von künstlichen kontrastverstärkten radiologischen aufnahmen
US20250045926A1 (en) 2023-07-25 2025-02-06 Bayer Aktiengesellschaft Detection of artifacts in synthetic images
EP4567715A1 (en) 2023-12-06 2025-06-11 Bayer Aktiengesellschaft Generating synthetic representations
EP4567716A1 (en) 2023-12-06 2025-06-11 Bayer Aktiengesellschaft Generating synthetic representations
EP4571650A1 (en) 2023-12-12 2025-06-18 Bayer AG Generating synthetic images

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US5560903A (en) 1981-07-24 1996-10-01 Schering Aktiengesellschaft Method of enhancing paramagnetism in chelates for MRI
DE3922005A1 (de) 1989-06-30 1991-01-10 Schering Ag Derivatisierte dtpa-komplexe, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung
GB9407435D0 (en) 1994-04-14 1994-06-08 Nycomed Salutar Inc Compounds
IT1269839B (it) 1994-05-26 1997-04-15 Bracco Spa Coniugati di acidi biliari, loro derivati con complessi metallici e relativi usi
US5672335A (en) 1994-11-30 1997-09-30 Schering Aktiengesellschaft Use of metal complexes as liver and gallbladder X-ray diagnostic agents
IT1283218B1 (it) 1996-03-08 1998-04-16 Bracco Spa Polichelanti, loro complessi con ioni metallici, loro preparazione e loro usi
IT1293778B1 (it) 1997-07-25 1999-03-10 Bracco Spa 1,4,7,10-tetraazabiciclo(8.2.2.)tetradecan-2 one, sua preparazione e suo uso per la preparazione di tetraazamacrocicli
EP1278553A2 (en) 2000-05-04 2003-01-29 Research Corporation Technologies, Inc Magnetic resonance imaging agents for the delivery of therapeutic agents
DE10135356C1 (de) * 2001-07-20 2003-04-17 Schering Ag Makrocyclische Metallkomplexe und deren Verwendung zur Herstellung von Konjugaten mit Biomolekülen
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DE102005033902B3 (de) 2005-07-15 2007-04-05 Schering Ag Perfluoralkylhaltige Komplexe, Verfahren zu deren Herstellung, sowie deren Verwendung und diese enthaltende pharmazeutische Mittel
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CN114364405B (zh) * 2019-04-26 2024-07-16 五一一制药股份有限公司 作为诊断剂和放射性核素治疗剂的前列腺特异性膜抗原(psma)抑制剂

Also Published As

Publication number Publication date
US20240182431A1 (en) 2024-06-06
ECSP23070062A (es) 2023-10-31
KR20230157412A (ko) 2023-11-16
PE20240821A1 (es) 2024-04-18
AR126325A1 (es) 2023-10-04
MX2023010737A (es) 2023-09-20
CN116981658A (zh) 2023-10-31
DOP2023000185A (es) 2023-10-15
BR112023017197A2 (pt) 2023-09-26
EP4308551A1 (en) 2024-01-24
CA3213386A1 (en) 2022-09-22
IL305294A (en) 2023-10-01
EP4308551C0 (en) 2025-04-09
GEP20257722B (en) 2025-01-27
WO2022194777A1 (en) 2022-09-22
CR20230433A (es) 2023-10-23
EP4059925A1 (en) 2022-09-21
TW202302543A (zh) 2023-01-16
JP2024512459A (ja) 2024-03-19
AU2022236333A1 (en) 2023-08-31
EP4308551B1 (en) 2025-04-09
CO2023012137A2 (es) 2023-09-29

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