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CL2019002912A1 - Métodos para detectar aav. (divisional solicitud 201900392). - Google Patents

Métodos para detectar aav. (divisional solicitud 201900392).

Info

Publication number
CL2019002912A1
CL2019002912A1 CL2019002912A CL2019002912A CL2019002912A1 CL 2019002912 A1 CL2019002912 A1 CL 2019002912A1 CL 2019002912 A CL2019002912 A CL 2019002912A CL 2019002912 A CL2019002912 A CL 2019002912A CL 2019002912 A1 CL2019002912 A1 CL 2019002912A1
Authority
CL
Chile
Prior art keywords
methods
aav
divisional application
determining
particles
Prior art date
Application number
CL2019002912A
Other languages
English (en)
Inventor
Xiaoying Jin
Catherine R O'riordan
Lin Liu
Kate Zhang
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=59762045&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2019002912(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genzyme Corp filed Critical Genzyme Corp
Publication of CL2019002912A1 publication Critical patent/CL2019002912A1/es

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • G—PHYSICS
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    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
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    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
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    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
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    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
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    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14123—Virus like particles [VLP]
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    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14151—Methods of production or purification of viral material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N2030/022—Column chromatography characterised by the kind of separation mechanism
    • G01N2030/027—Liquid chromatography
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/01—DNA viruses
    • G01N2333/075—Adenoviridae

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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

MÉTODOS PARA DETERMINAR EL SEROTIPO DE UNA PARTÍCULA DE VIRUS Y/O PARA DETERMINAR LA HETEROGENEIDAD DE UNA PARTÍCULA DE VIRUS (P. EJ., UNA PARTÍCULA DE AAV); MÉTODOS PARA DETERMINAR LA HETEROGENEIDAD DE PARTÍCULAS DE AAV; PARTÍCULAS VIRALES (P. EJ., PARTÍCULAS DE AAVR) CON ESTABILIDAD MEJORADA Y/O EFICIENCIA DE LA TRANSDUCCIÓN MEJORADA MEDIANTE EL INCREMENTO DE LA ACETILACIÓN Y/O DESAMIDACIÓN DE LAS PROTEÍNAS DE LA CÁPSIDE.
CL2019002912A 2016-08-15 2019-10-14 Métodos para detectar aav. (divisional solicitud 201900392). CL2019002912A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662375314P 2016-08-15 2016-08-15

Publications (1)

Publication Number Publication Date
CL2019002912A1 true CL2019002912A1 (es) 2020-03-06

Family

ID=59762045

Family Applications (2)

Application Number Title Priority Date Filing Date
CL2019000392A CL2019000392A1 (es) 2016-08-15 2019-02-13 Métodos para detectar aav.
CL2019002912A CL2019002912A1 (es) 2016-08-15 2019-10-14 Métodos para detectar aav. (divisional solicitud 201900392).

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CL2019000392A CL2019000392A1 (es) 2016-08-15 2019-02-13 Métodos para detectar aav.

Country Status (23)

Country Link
US (3) US11698377B2 (es)
EP (2) EP3851449A1 (es)
JP (3) JP7021191B2 (es)
KR (4) KR102425289B1 (es)
CN (2) CN110168080B (es)
AU (2) AU2017312951B2 (es)
BR (1) BR112019002934A2 (es)
CA (1) CA3033856A1 (es)
CL (2) CL2019000392A1 (es)
CR (1) CR20190127A (es)
CY (1) CY1124364T1 (es)
DK (1) DK3497207T3 (es)
ES (1) ES2863674T3 (es)
HU (1) HUE053747T2 (es)
IL (2) IL264819B2 (es)
MA (1) MA55748A (es)
MX (2) MX2019001938A (es)
PH (1) PH12019500316A1 (es)
SG (2) SG11201901221YA (es)
TN (1) TN2019000047A1 (es)
TW (2) TWI781953B (es)
WO (1) WO2018035059A1 (es)
ZA (2) ZA201900945B (es)

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TW201825898A (zh) 2018-07-16
JP2024023460A (ja) 2024-02-21
CN118688363A (zh) 2024-09-24
EP3497207B1 (en) 2021-01-06
KR102425289B1 (ko) 2022-07-27
DK3497207T3 (da) 2021-03-22
MX2023009081A (es) 2023-08-08
CY1124364T1 (el) 2022-07-22
EP3851449A1 (en) 2021-07-21
SG11201901221YA (en) 2019-03-28
PH12019500316A1 (en) 2019-08-05
KR102738219B1 (ko) 2024-12-05
US12123880B2 (en) 2024-10-22
US20210041451A1 (en) 2021-02-11
IL264819B1 (en) 2024-06-01
MX2019001938A (es) 2019-07-04
US20250027951A1 (en) 2025-01-23
ZA201900945B (en) 2021-06-30
AU2017312951A1 (en) 2019-04-04
KR102538037B1 (ko) 2023-05-30
ZA202101002B (en) 2024-07-31
MA55748A (fr) 2022-03-02
EP3497207A1 (en) 2019-06-19
AU2017312951B2 (en) 2024-02-08
KR20190039253A (ko) 2019-04-10
CA3033856A1 (en) 2018-02-22
US20240044910A1 (en) 2024-02-08
IL264819B2 (en) 2024-10-01
SG10201913002QA (en) 2020-03-30
KR20230078834A (ko) 2023-06-02
US11698377B2 (en) 2023-07-11
ES2863674T3 (es) 2021-10-11
RU2019107207A3 (es) 2021-04-29
HUE053747T2 (hu) 2021-07-28
KR20220107327A (ko) 2022-08-02
WO2018035059A9 (en) 2019-03-14
JP7021191B2 (ja) 2022-02-16
BR112019002934A2 (pt) 2019-05-14
AU2024200349A1 (en) 2024-02-08
WO2018035059A1 (en) 2018-02-22
TW202309068A (zh) 2023-03-01
TN2019000047A1 (en) 2020-07-15
CR20190127A (es) 2019-06-25
CN110168080A (zh) 2019-08-23
JP2019533803A (ja) 2019-11-21
JP2022064980A (ja) 2022-04-26
IL264819A (es) 2019-04-30
TWI781953B (zh) 2022-11-01
KR20240172773A (ko) 2024-12-10
IL312792A (en) 2024-07-01
RU2019107207A (ru) 2020-09-15
CN110168080B (zh) 2024-05-31
CL2019000392A1 (es) 2019-05-10

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