CL2019001551A1 - Compuestos de 7-feniletilamino-4h-pirimido[4,5-d][1,3]-oxazin-2-ona como inhibidores de idh1 e idh2 mutantes - Google Patents
Compuestos de 7-feniletilamino-4h-pirimido[4,5-d][1,3]-oxazin-2-ona como inhibidores de idh1 e idh2 mutantesInfo
- Publication number
- CL2019001551A1 CL2019001551A1 CL2019001551A CL2019001551A CL2019001551A1 CL 2019001551 A1 CL2019001551 A1 CL 2019001551A1 CL 2019001551 A CL2019001551 A CL 2019001551A CL 2019001551 A CL2019001551 A CL 2019001551A CL 2019001551 A1 CL2019001551 A1 CL 2019001551A1
- Authority
- CL
- Chile
- Prior art keywords
- phenylethylamino
- pyrimido
- oxazin
- compounds
- mutant idh1
- Prior art date
Links
- USFRTQXJZLVVJL-UHFFFAOYSA-N 7-(2-phenylethylamino)-1,4-dihydropyrimido[4,5-d][1,3]oxazin-2-one Chemical class C1(=CC=CC=C1)CCNC=1N=CC2=C(NC(OC2)=O)N=1 USFRTQXJZLVVJL-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 101001042041 Bos taurus Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial Proteins 0.000 abstract 1
- 101000960234 Homo sapiens Isocitrate dehydrogenase [NADP] cytoplasmic Proteins 0.000 abstract 1
- 101000599886 Homo sapiens Isocitrate dehydrogenase [NADP], mitochondrial Proteins 0.000 abstract 1
- 102100039905 Isocitrate dehydrogenase [NADP] cytoplasmic Human genes 0.000 abstract 1
- 102100037845 Isocitrate dehydrogenase [NADP], mitochondrial Human genes 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
UN COMPUESTO, COMO SE DEFINE EN LA PRESENTE, O COMPOSICIÓN FARMACÉUTICA QUE CONTIENE EL COMPUESTO, PARA USAR EN EL TRATAMIENTO DEL CÁNCER MUTANTE DE IDH1 O IDH2.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662435283P | 2016-12-16 | 2016-12-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2019001551A1 true CL2019001551A1 (es) | 2019-10-25 |
Family
ID=60888651
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2019001551A CL2019001551A1 (es) | 2016-12-16 | 2019-06-06 | Compuestos de 7-feniletilamino-4h-pirimido[4,5-d][1,3]-oxazin-2-ona como inhibidores de idh1 e idh2 mutantes |
Country Status (37)
| Country | Link |
|---|---|
| US (3) | US11001596B2 (es) |
| EP (2) | EP3763717B1 (es) |
| JP (1) | JP6793836B2 (es) |
| KR (1) | KR102276022B1 (es) |
| CN (2) | CN115109075B (es) |
| AU (2) | AU2017378060B2 (es) |
| CA (1) | CA3045303C (es) |
| CL (1) | CL2019001551A1 (es) |
| CO (1) | CO2019005287A2 (es) |
| CR (1) | CR20190252A (es) |
| CY (1) | CY1123577T1 (es) |
| DK (1) | DK3555105T3 (es) |
| DO (1) | DOP2019000163A (es) |
| EA (1) | EA036112B1 (es) |
| EC (1) | ECSP19042682A (es) |
| ES (2) | ES2941631T3 (es) |
| HR (1) | HRP20201882T1 (es) |
| HU (1) | HUE052067T2 (es) |
| IL (1) | IL267236B (es) |
| JO (1) | JOP20190142B1 (es) |
| LT (1) | LT3555105T (es) |
| MA (2) | MA47399B1 (es) |
| MD (1) | MD3555105T2 (es) |
| MX (1) | MX2019006830A (es) |
| MY (1) | MY197313A (es) |
| NZ (1) | NZ754115A (es) |
| PE (1) | PE20190977A1 (es) |
| PH (1) | PH12019501328B1 (es) |
| PL (1) | PL3555105T3 (es) |
| PT (1) | PT3555105T (es) |
| RS (1) | RS61108B1 (es) |
| SA (1) | SA519401897B1 (es) |
| SI (1) | SI3555105T1 (es) |
| TN (1) | TN2019000158A1 (es) |
| UA (1) | UA123640C2 (es) |
| WO (1) | WO2018111707A1 (es) |
| ZA (1) | ZA201903125B (es) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10981911B2 (en) | 2016-12-16 | 2021-04-20 | Janssen Pharmaceutica Nv | Imidazopyrrolopyridine as inhibitors of the JAK family of kinases |
| US11059823B2 (en) | 2016-12-16 | 2021-07-13 | Janssen Pharmaceutica Nv | Small molecule inhibitors of the JAK family of kinases |
| US11066406B2 (en) | 2018-06-15 | 2021-07-20 | Janssen Pharmaceutica Nv | Small molecule inhibitors of the JAK family of kinases |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT3447050T (lt) | 2014-09-19 | 2020-05-11 | Forma Therapeutics, Inc. | Piridin-2(1h)-ono chinolinono dariniai, kaip mutantinės izocitrato dehidrogenazės inhibitoriai |
| MX373789B (es) | 2014-09-19 | 2025-03-04 | Forma Therapeutics Inc | Derivados de piridinil quinolinona como inhibidores de isocitrato deshidrogenasa mutante (mt-idh). |
| JP6648116B2 (ja) | 2014-09-19 | 2020-02-14 | フォーマ セラピューティクス，インコーポレイテッド | 変異イソクエン酸デヒドロゲナーゼ阻害剤としてのキノリノンピリミジン組成物 |
| CA2961807A1 (en) | 2014-09-19 | 2016-03-24 | Forma Therapeutics, Inc. | Phenyl quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors |
| US10294206B2 (en) | 2015-04-21 | 2019-05-21 | Forma Tm2, Inc. | Fused-bicyclic aryl quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors |
| US9624216B2 (en) | 2015-04-21 | 2017-04-18 | Forma Therapeutics, Inc. | Quinolinone five-membered heterocyclic compounds as mutant-isocitrate dehydrogenase inhibitors |
| UA125824C2 (uk) | 2016-10-24 | 2022-06-15 | Астразенека Аб | 6,7,8,9-ТЕТРАГІДРО-3H-ПІРАЗОЛО[4,3-f]ІЗОХІНОЛІНОВІ ПОХІДНІ, ЗАСТОСОВНІ В ЛІКУВАННІ РАКУ |
| CN115109075B (zh) * | 2016-12-16 | 2024-09-20 | 伊莱利利公司 | 突变体idh1和idh2抑制剂 |
| US10221173B2 (en) | 2017-01-30 | 2019-03-05 | Astrazeneca Ab | Chemical compounds |
| US11013734B2 (en) | 2018-05-16 | 2021-05-25 | Forma Therapeutics, Inc. | Treating patients harboring an isocitrate dehydrogenase-1 (IDH-1) mutation |
| US11311527B2 (en) | 2018-05-16 | 2022-04-26 | Forma Therapeutics, Inc. | Inhibiting mutant isocitrate dehydrogenase 1 (mIDH-1) |
| US11013733B2 (en) | 2018-05-16 | 2021-05-25 | Forma Therapeutics, Inc. | Inhibiting mutant isocitrate dehydrogenase 1 (mlDH-1) |
| US10532047B2 (en) | 2018-05-16 | 2020-01-14 | Forma Therapeutics, Inc. | Solid forms of ((S)-5-((1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)amino)-1-methyl-6-oxo-1,6-dihydropyridine-2-carbonitrile |
| US11576906B2 (en) | 2018-05-16 | 2023-02-14 | Forma Therapeutics, Inc. | Inhibiting mutant IDH-1 |
| EP4055015B1 (en) * | 2019-11-08 | 2025-04-02 | Nerviano Medical Sciences S.r.l. | Gem-disubstituted heterocyclic compounds and their use as idh inhibitors |
| CN115335059A (zh) * | 2020-03-23 | 2022-11-11 | 伊莱利利公司 | 用于治疗idh1抑制剂抗性受试者的方法 |
| MX2022011845A (es) * | 2020-03-23 | 2023-02-16 | Lilly Co Eli | Terapia combinada con un inhibidor de idh mutante y un inhibidor de bcl-2. |
| BR112022017394A2 (pt) | 2020-03-23 | 2022-10-18 | Lilly Co Eli | Terapia de combinação com um inibidor de idh mutante |
| WO2022001916A1 (zh) * | 2020-06-28 | 2022-01-06 | 微境生物医药科技(上海)有限公司 | Idh突变体抑制剂及其用途 |
| CA3186786A1 (en) | 2020-07-20 | 2022-01-27 | David Michael HYMAN | Combination therapy with a mutant idh1 inhibitor, a deoxyadenosine analog, and a platinum agent |
| CN113588768B (zh) * | 2021-05-18 | 2022-07-05 | 国家卫生健康委科学技术研究所 | 一种以分子图像方式定量组织内内源性代谢物的质谱方法 |
| EP4337217A1 (en) | 2021-06-09 | 2024-03-20 | Eli Lilly and Company | Method for treating idh inhibitor-resistant subjects |
| US20240208978A1 (en) * | 2021-06-15 | 2024-06-27 | Wigen Biomedicine Technology (shanghai) Co., Ltd. | Idh mutant inhibitor and use thereof |
| EP4384273A1 (en) | 2021-08-13 | 2024-06-19 | Eli Lilly and Company | Solid forms of 7-[[(1s)-1-[4-[(1s)-2-cyclopropyl-1-(4-prop-2- enoylpiperazin-1-yl)ethyl]phenyl]ethyl]amino]-1-ethyl-4h- pyrimido[4,5-d] [1,3]oxazin-2-one |
| WO2023141087A1 (en) | 2022-01-19 | 2023-07-27 | Eli Lilly And Company | Combination therapy with a mutant idh inhibitor |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201400989TA (en) * | 2011-09-27 | 2014-04-28 | Novartis Ag | 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh |
| CA2903176A1 (en) * | 2013-03-14 | 2014-09-18 | Novartis Ag | 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh |
| WO2014147586A1 (en) * | 2013-03-22 | 2014-09-25 | Novartis Ag | 1-(2-(ethylamino)pyrimidin-4-yl)pyrrolidin-2-ones as inhibitors of mutant idh |
| US10294206B2 (en) * | 2015-04-21 | 2019-05-21 | Forma Tm2, Inc. | Fused-bicyclic aryl quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors |
| WO2016171715A1 (en) * | 2015-04-24 | 2016-10-27 | Halliburton Energy Services, Inc. | Methods of fabricating ceramic or intermetallic parts |
| CN107849059B (zh) | 2015-07-27 | 2020-04-28 | 伊莱利利公司 | 7-苯基乙基氨基-4h-嘧啶并[4,5-d][1,3]噁嗪-2-酮化合物及其作为突变体idh1抑制剂的用途 |
| WO2017213910A1 (en) * | 2016-06-06 | 2017-12-14 | Eli Lilly And Company | Mutant idh1 inhibitors |
| CN115109075B (zh) * | 2016-12-16 | 2024-09-20 | 伊莱利利公司 | 突变体idh1和idh2抑制剂 |
-
2017
- 2017-12-08 CN CN202210758386.7A patent/CN115109075B/zh active Active
- 2017-12-08 EA EA201991161A patent/EA036112B1/ru not_active IP Right Cessation
- 2017-12-08 LT LTEP17822882.1T patent/LT3555105T/lt unknown
- 2017-12-08 MD MDE20191188T patent/MD3555105T2/ro unknown
- 2017-12-08 NZ NZ754115A patent/NZ754115A/en unknown
- 2017-12-08 CN CN201780078017.0A patent/CN110072867B/zh active Active
- 2017-12-08 MA MA47399A patent/MA47399B1/fr unknown
- 2017-12-08 ES ES20189241T patent/ES2941631T3/es active Active
- 2017-12-08 JP JP2019532088A patent/JP6793836B2/ja active Active
- 2017-12-08 CA CA3045303A patent/CA3045303C/en active Active
- 2017-12-08 PL PL17822882T patent/PL3555105T3/pl unknown
- 2017-12-08 PT PT178228821T patent/PT3555105T/pt unknown
- 2017-12-08 RS RS20201429A patent/RS61108B1/sr unknown
- 2017-12-08 AU AU2017378060A patent/AU2017378060B2/en active Active
- 2017-12-08 TN TNP/2019/000158A patent/TN2019000158A1/en unknown
- 2017-12-08 EP EP20189241.1A patent/EP3763717B1/en active Active
- 2017-12-08 US US16/349,873 patent/US11001596B2/en active Active
- 2017-12-08 JO JOP/2019/0142A patent/JOP20190142B1/ar active
- 2017-12-08 HU HUE17822882A patent/HUE052067T2/hu unknown
- 2017-12-08 MA MA053881A patent/MA53881A/fr unknown
- 2017-12-08 PH PH1/2019/501328A patent/PH12019501328B1/en unknown
- 2017-12-08 ES ES17822882T patent/ES2835281T3/es active Active
- 2017-12-08 MX MX2019006830A patent/MX2019006830A/es unknown
- 2017-12-08 KR KR1020197016855A patent/KR102276022B1/ko active Active
- 2017-12-08 DK DK17822882.1T patent/DK3555105T3/da active
- 2017-12-08 SI SI201730488T patent/SI3555105T1/sl unknown
- 2017-12-08 UA UAA201905584A patent/UA123640C2/uk unknown
- 2017-12-08 CR CR20190252A patent/CR20190252A/es unknown
- 2017-12-08 PE PE2019001077A patent/PE20190977A1/es unknown
- 2017-12-08 MY MYPI2019003350A patent/MY197313A/en unknown
- 2017-12-08 EP EP17822882.1A patent/EP3555105B1/en active Active
- 2017-12-08 WO PCT/US2017/065246 patent/WO2018111707A1/en active Application Filing
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2019
- 2019-05-17 ZA ZA2019/03125A patent/ZA201903125B/en unknown
- 2019-05-23 CO CONC2019/0005287A patent/CO2019005287A2/es unknown
- 2019-05-30 SA SA519401897A patent/SA519401897B1/ar unknown
- 2019-06-06 CL CL2019001551A patent/CL2019001551A1/es unknown
- 2019-06-11 DO DO2019000163A patent/DOP2019000163A/es unknown
- 2019-06-11 IL IL267236A patent/IL267236B/en active IP Right Grant
- 2019-06-14 EC ECSENADI201942682A patent/ECSP19042682A/es unknown
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2020
- 2020-10-29 AU AU2020260493A patent/AU2020260493B2/en active Active
- 2020-11-25 CY CY20201101122T patent/CY1123577T1/el unknown
- 2020-11-26 HR HRP20201882TT patent/HRP20201882T1/hr unknown
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2021
- 2021-03-16 US US17/202,515 patent/US11649247B2/en active Active
- 2021-03-16 US US17/202,867 patent/US11629156B2/en active Active
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10981911B2 (en) | 2016-12-16 | 2021-04-20 | Janssen Pharmaceutica Nv | Imidazopyrrolopyridine as inhibitors of the JAK family of kinases |
| US11059823B2 (en) | 2016-12-16 | 2021-07-13 | Janssen Pharmaceutica Nv | Small molecule inhibitors of the JAK family of kinases |
| US11827638B2 (en) | 2016-12-16 | 2023-11-28 | Janssen Pharmaceutica Nv | Imidazopyrrolopyridine as inhibitors of the JAK family of kinases |
| US12202831B2 (en) | 2016-12-16 | 2025-01-21 | Janssen Pharmaceutica Nv | Small molecule inhibitors of the JAK family of kinases |
| US11066406B2 (en) | 2018-06-15 | 2021-07-20 | Janssen Pharmaceutica Nv | Small molecule inhibitors of the JAK family of kinases |
| US11787807B2 (en) | 2018-06-15 | 2023-10-17 | Janssen Pharmaceutica Nv | Small molecule inhibitors of the JAK family of kinases |
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