CL2017001920A1 - Anticuerpos humanos contra glicoproteína del virus ébola - Google Patents
Anticuerpos humanos contra glicoproteína del virus ébolaInfo
- Publication number
- CL2017001920A1 CL2017001920A1 CL2017001920A CL2017001920A CL2017001920A1 CL 2017001920 A1 CL2017001920 A1 CL 2017001920A1 CL 2017001920 A CL2017001920 A CL 2017001920A CL 2017001920 A CL2017001920 A CL 2017001920A CL 2017001920 A1 CL2017001920 A1 CL 2017001920A1
- Authority
- CL
- Chile
- Prior art keywords
- antibodies
- virus
- ebola virus
- human antibodies
- antibodies against
- Prior art date
Links
- 241001115402 Ebolavirus Species 0.000 title abstract 2
- 102000003886 Glycoproteins Human genes 0.000 title 1
- 108090000288 Glycoproteins Proteins 0.000 title 1
- 241000700605 Viruses Species 0.000 abstract 3
- 201000011001 Ebola Hemorrhagic Fever Diseases 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 239000003443 antiviral agent Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
<p>LA PRESENTE INVENCIÓN PROPORCIONA ANTICUERPOS MONOCLONALES, O FRAGMENTOS DE LOS MISMOS QUE UNEN ANTÍGENOS, QUE ADHIEREN GLICOPROTEÍNAS DEL VIRUS ÉBOLA, COMPOSICIONES FARMACÉUTICAS QUE COMPRENDEN LOS ANTICUERPOS Y MÉTODOS DE USO. LOS ANTICUERPOS DE LA INVENCIÓN SON ÚTILES PARA INHIBIR O NEUTRALIZAR LA ACTIVIDAD DEL VIRUS ÉBOLA, ASÍ PROPORCIONANDO UN MEDIO PARA TRATAR O PREVENIR LA INFECCIÓN DEL VIRUS ÉBOLA EN HUMANOS. EN ALGUNAS REALIZACIONES, LA INVENCIÓN PROPORCIONA EL USO DE UNO O MÁS ANTICUERPOS QUE UNEN EL VIRUS ÉBOLA PARA PREVENIR LA UNIÓN VIRAL Y/O LA ENTRADA A LAS CÉLULAS HOSPEDERAS. LOS ANTICUERPOS DE LA INVENCIÓN PUEDEN SER UTILIZADOS PROFILÁCTICAMENTE O TERAPÉUTICAMENTE Y PUEDEN SER UTILIZADOS SOLOS O EN COMBINACIÓN CON UNO O MÁS DE OTROS AGENTES ANTIVIRALES O VACUNAS.</p>
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562107581P | 2015-01-26 | 2015-01-26 | |
| US201562161356P | 2015-05-14 | 2015-05-14 | |
| US201562245703P | 2015-10-23 | 2015-10-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2017001920A1 true CL2017001920A1 (es) | 2018-03-02 |
Family
ID=55300806
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2017001920A CL2017001920A1 (es) | 2015-01-26 | 2017-07-26 | Anticuerpos humanos contra glicoproteína del virus ébola |
| CL2020000498A CL2020000498A1 (es) | 2015-01-26 | 2020-02-28 | Composiciones farmacéuticas que contienen anticuerpos contra la glicoproteína del virus ébola. (divisional solicitud 201701920) |
| CL2022003763A CL2022003763A1 (es) | 2015-01-26 | 2022-12-26 | Anticuerpos humanos contra glicoproteína del virus ébola |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2020000498A CL2020000498A1 (es) | 2015-01-26 | 2020-02-28 | Composiciones farmacéuticas que contienen anticuerpos contra la glicoproteína del virus ébola. (divisional solicitud 201701920) |
| CL2022003763A CL2022003763A1 (es) | 2015-01-26 | 2022-12-26 | Anticuerpos humanos contra glicoproteína del virus ébola |
Country Status (20)
| Country | Link |
|---|---|
| US (6) | US9771414B2 (es) |
| EP (1) | EP3250591A1 (es) |
| JP (4) | JP6829199B2 (es) |
| KR (1) | KR102641731B1 (es) |
| CN (2) | CN107667115B (es) |
| AU (2) | AU2016211783B2 (es) |
| BR (1) | BR112017015845A2 (es) |
| CA (1) | CA2974899A1 (es) |
| CL (3) | CL2017001920A1 (es) |
| CO (1) | CO2017007619A2 (es) |
| EA (1) | EA038993B1 (es) |
| IL (1) | IL253358B (es) |
| MA (1) | MA41421A (es) |
| MX (2) | MX392533B (es) |
| MY (3) | MY180045A (es) |
| PH (1) | PH12017501277B1 (es) |
| SG (2) | SG11201705681YA (es) |
| TW (1) | TWI710573B (es) |
| UY (1) | UY36538A (es) |
| WO (1) | WO2016123019A1 (es) |
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| US11542332B2 (en) | 2016-03-26 | 2023-01-03 | Bioatla, Inc. | Anti-CTLA4 antibodies, antibody fragments, their immunoconjugates and uses thereof |
| EP3487521A4 (en) | 2016-07-21 | 2020-07-01 | Emory University | ANTIBODIES AGAINST EBOLA VIRUS AND LIAISON AGENTS DERIVED THEREFROM |
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