CL2017000640A1 - Nuevos activadores de la guanilato ciclasa soluble y su uso - Google Patents
Nuevos activadores de la guanilato ciclasa soluble y su usoInfo
- Publication number
- CL2017000640A1 CL2017000640A1 CL2017000640A CL2017000640A CL2017000640A1 CL 2017000640 A1 CL2017000640 A1 CL 2017000640A1 CL 2017000640 A CL2017000640 A CL 2017000640A CL 2017000640 A CL2017000640 A CL 2017000640A CL 2017000640 A1 CL2017000640 A1 CL 2017000640A1
- Authority
- CL
- Chile
- Prior art keywords
- guanylate cyclase
- soluble guanylate
- activators
- new activators
- pharmaceutical compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Abstract
<p>LA INVENCIÓN SE REFIERE A ACTIVADORES DE LA GUANILATO CICLASA SOLUBLE Y SU USO EN COMPOSICIONES FARMACÉUTICAS, PRINCIPALMENTE COMPOSICIONES OFTÁLMICAS ADMINISTRADAS POR VÍA TÓPICA. LAS COMPOSICIONES FARMACÉUTICAS SON ÚTILES PARA REDUCIR LA PRESIÓN INTRAOCULAR EN LOS ANIMALES DE LAS ESPECIES DE MAMÍFEROS.</p>
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462052537P | 2014-09-19 | 2014-09-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2017000640A1 true CL2017000640A1 (es) | 2017-10-06 |
Family
ID=54238488
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2017000640A CL2017000640A1 (es) | 2014-09-19 | 2017-03-16 | Nuevos activadores de la guanilato ciclasa soluble y su uso |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US9938260B2 (es) |
| EP (1) | EP3194384A1 (es) |
| JP (3) | JP6678656B2 (es) |
| KR (1) | KR20170054508A (es) |
| CN (1) | CN106687456B (es) |
| AU (1) | AU2015319724B2 (es) |
| BR (1) | BR112017005660A2 (es) |
| CA (1) | CA2961745A1 (es) |
| CL (1) | CL2017000640A1 (es) |
| CO (1) | CO2017002506A2 (es) |
| CR (1) | CR20170102A (es) |
| DO (1) | DOP2017000073A (es) |
| EA (1) | EA033697B1 (es) |
| IL (1) | IL251094A0 (es) |
| MA (1) | MA40583A (es) |
| MX (1) | MX2017003621A (es) |
| PE (1) | PE20170937A1 (es) |
| PH (1) | PH12017500481A1 (es) |
| SG (1) | SG11201701915TA (es) |
| WO (1) | WO2016042536A1 (es) |
| ZA (1) | ZA201701835B (es) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10350206B2 (en) | 2014-09-19 | 2019-07-16 | Bayer Pharma Aktiengesellschaft | Benzyl substituted indazoles as BUB1 inhibitors |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3102568B1 (en) | 2014-02-06 | 2018-06-27 | Heptares Therapeutics Limited | Bicyclic aza compounds as muscarinic m1 receptor agonists. |
| PE20170937A1 (es) * | 2014-09-19 | 2017-07-13 | Glaxosmithkline Ip Dev Ltd | Nuevos activadores de la guanilato ciclasa soluble y su uso |
| WO2018069148A1 (de) | 2016-10-11 | 2018-04-19 | Bayer Pharma Aktiengesellschaft | Kombination enthaltend sgc aktivatoren und mineralocorticoid-rezeptor-antagonisten |
| WO2019081456A1 (en) | 2017-10-24 | 2019-05-02 | Bayer Aktiengesellschaft | USE OF SGC ACTIVATORS AND STIMULATORS COMPRISING A BETA2 SUBUNIT |
| EP3498298A1 (en) | 2017-12-15 | 2019-06-19 | Bayer AG | The use of sgc stimulators and sgc activators alone or in combination with pde5 inhibitors for the treatment of bone disorders including osteogenesis imperfecta (oi) |
| WO2019211081A1 (en) | 2018-04-30 | 2019-11-07 | Bayer Aktiengesellschaft | The use of sgc activators and sgc stimulators for the treatment of cognitive impairment |
| EA202092680A1 (ru) | 2018-05-15 | 2021-04-13 | Байер Акциенгезельшафт | 1,3-тиазол-2-ил-замещенные бензамиды для лечения заболеваний, ассоциированных с сенситизацией нервных волокон |
| US11508483B2 (en) | 2018-05-30 | 2022-11-22 | Adverio Pharma Gmbh | Method of identifying a subgroup of patients suffering from dcSSc which benefits from a treatment with sGC stimulators and sGC activators in a higher degree than a control group |
| US20220128561A1 (en) | 2019-01-17 | 2022-04-28 | Bayer Aktiengesellschaft | Methods to determine whether a subject is suitable of being treated with an agonist of soluble gyanylyl cyclase (sgc) |
| TW202412753A (zh) | 2022-06-09 | 2024-04-01 | 德商拜耳廠股份有限公司 | 用於治療女性心臟衰竭合併保留射出分率的可溶性鳥苷酸環化酶活化劑 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5602143A (en) | 1994-12-08 | 1997-02-11 | Allergan | Method for reducing intraocular pressure in the mammalian eye by administration of guanylate cyclase inhibitors |
| ES2477993T3 (es) * | 2006-11-09 | 2014-07-18 | Alcon Research, Ltd. | Matriz de polímero insoluble en agua para el suministro de fármaco |
| UY31507A1 (es) * | 2007-12-03 | 2009-07-17 | Derivados de piridina activadores de guanilato ciclasa soluble | |
| WO2010015653A1 (en) * | 2008-08-07 | 2010-02-11 | Smithkline Beecham Corporation | Pyrimidine derivatives as activators of soluble guanylate cyclase |
| KR20110133034A (ko) | 2009-02-26 | 2011-12-09 | 머크 샤프 앤드 돔 코포레이션 | 가용성 구아닐레이트 시클라제 활성화제 |
| DE102009012314A1 (de) * | 2009-03-09 | 2010-09-16 | Bayer Schering Pharma Aktiengesellschaft | Oxo-heterocyclisch substituierte Alkylcarbonsäuren und ihre Verwendung |
| JP5636296B2 (ja) | 2011-01-20 | 2014-12-03 | 公益財団法人微生物化学研究会 | 塩分含有有機廃液処理剤、並びに、塩分濃度低下剤、塩分含有有機廃液の処理方法、及び包括固定担体 |
| PE20170937A1 (es) * | 2014-09-19 | 2017-07-13 | Glaxosmithkline Ip Dev Ltd | Nuevos activadores de la guanilato ciclasa soluble y su uso |
-
2015
- 2015-09-18 PE PE2017000478A patent/PE20170937A1/es unknown
- 2015-09-18 CR CR20170102A patent/CR20170102A/es unknown
- 2015-09-18 US US15/509,895 patent/US9938260B2/en active Active
- 2015-09-18 WO PCT/IB2015/057219 patent/WO2016042536A1/en active Application Filing
- 2015-09-18 EP EP15772026.9A patent/EP3194384A1/en not_active Withdrawn
- 2015-09-18 MA MA040583A patent/MA40583A/fr unknown
- 2015-09-18 CA CA2961745A patent/CA2961745A1/en not_active Abandoned
- 2015-09-18 MX MX2017003621A patent/MX2017003621A/es unknown
- 2015-09-18 JP JP2017515074A patent/JP6678656B2/ja active Active
- 2015-09-18 EA EA201790655A patent/EA033697B1/ru not_active IP Right Cessation
- 2015-09-18 BR BR112017005660A patent/BR112017005660A2/pt not_active Application Discontinuation
- 2015-09-18 CN CN201580050717.XA patent/CN106687456B/zh active Active
- 2015-09-18 KR KR1020177010181A patent/KR20170054508A/ko not_active Ceased
- 2015-09-18 AU AU2015319724A patent/AU2015319724B2/en active Active
- 2015-09-18 SG SG11201701915TA patent/SG11201701915TA/en unknown
-
2017
- 2017-03-12 IL IL251094A patent/IL251094A0/en unknown
- 2017-03-14 PH PH12017500481A patent/PH12017500481A1/en unknown
- 2017-03-14 ZA ZA2017/01835A patent/ZA201701835B/en unknown
- 2017-03-16 DO DO2017000073A patent/DOP2017000073A/es unknown
- 2017-03-16 CL CL2017000640A patent/CL2017000640A1/es unknown
- 2017-03-16 CO CONC2017/0002506A patent/CO2017002506A2/es unknown
-
2018
- 2018-03-05 US US15/911,797 patent/US10472350B2/en active Active
-
2020
- 2020-03-02 JP JP2020035272A patent/JP6908747B2/ja active Active
-
2021
- 2021-06-30 JP JP2021109106A patent/JP2021155450A/ja active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10350206B2 (en) | 2014-09-19 | 2019-07-16 | Bayer Pharma Aktiengesellschaft | Benzyl substituted indazoles as BUB1 inhibitors |
Also Published As
| Publication number | Publication date |
|---|---|
| MX2017003621A (es) | 2017-07-14 |
| WO2016042536A1 (en) | 2016-03-24 |
| CO2017002506A2 (es) | 2017-07-28 |
| JP2017527602A (ja) | 2017-09-21 |
| KR20170054508A (ko) | 2017-05-17 |
| PH12017500481A1 (en) | 2017-08-07 |
| PE20170937A1 (es) | 2017-07-13 |
| US20180194756A1 (en) | 2018-07-12 |
| JP2021155450A (ja) | 2021-10-07 |
| JP6908747B2 (ja) | 2021-07-28 |
| JP2020105189A (ja) | 2020-07-09 |
| ZA201701835B (en) | 2018-12-19 |
| CA2961745A1 (en) | 2016-03-24 |
| CN106687456B (zh) | 2019-12-03 |
| US20170305888A1 (en) | 2017-10-26 |
| US9938260B2 (en) | 2018-04-10 |
| CN106687456A (zh) | 2017-05-17 |
| SG11201701915TA (en) | 2017-04-27 |
| EA033697B1 (ru) | 2019-11-18 |
| US10472350B2 (en) | 2019-11-12 |
| DOP2017000073A (es) | 2017-04-16 |
| JP6678656B2 (ja) | 2020-04-08 |
| IL251094A0 (en) | 2017-04-30 |
| EP3194384A1 (en) | 2017-07-26 |
| CR20170102A (es) | 2017-07-17 |
| BR112017005660A2 (pt) | 2017-12-19 |
| AU2015319724A1 (en) | 2017-04-06 |
| AU2015319724B2 (en) | 2018-05-10 |
| MA40583A (fr) | 2016-03-24 |
| EA201790655A1 (ru) | 2017-08-31 |
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