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CL2016000026A1 - Nuevos derivados de azabencimidazol - Google Patents

Nuevos derivados de azabencimidazol

Info

Publication number
CL2016000026A1
CL2016000026A1 CL2016000026A CL2016000026A CL2016000026A1 CL 2016000026 A1 CL2016000026 A1 CL 2016000026A1 CL 2016000026 A CL2016000026 A CL 2016000026A CL 2016000026 A CL2016000026 A CL 2016000026A CL 2016000026 A1 CL2016000026 A1 CL 2016000026A1
Authority
CL
Chile
Prior art keywords
azabenzimidazole derivatives
new
new azabenzimidazole
derivatives
compounds
Prior art date
Application number
CL2016000026A
Other languages
English (en)
Inventor
Holger Wagner
Frank Himmelsbach
Elke Langkopf
Norbert Redemann
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of CL2016000026A1 publication Critical patent/CL2016000026A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

COMPUESTOS DERIVADOS DE AZABENCIMIDAZOL; SAL DE LOS COMPUESTOS; COMPOSICION FARMACEUTICA QUE LOS COMPRENDE Y EL USO EN EL TRATAMIENTO Y/O PROFILAXIS DE ENFERMEDADES METABOLICAS, TALES COMO DIABETES MELLITUS TIPO 2.
CL2016000026A 2013-07-17 2016-01-07 Nuevos derivados de azabencimidazol CL2016000026A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP13176929 2013-07-17

Publications (1)

Publication Number Publication Date
CL2016000026A1 true CL2016000026A1 (es) 2016-08-12

Family

ID=48790302

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2016000026A CL2016000026A1 (es) 2013-07-17 2016-01-07 Nuevos derivados de azabencimidazol

Country Status (20)

Country Link
US (1) US9492436B2 (es)
EP (1) EP3022210B1 (es)
JP (1) JP6491656B2 (es)
KR (1) KR20160033749A (es)
CN (1) CN105377857B (es)
AR (1) AR096936A1 (es)
AU (1) AU2014292236B2 (es)
CA (1) CA2918401A1 (es)
CL (1) CL2016000026A1 (es)
DK (1) DK3022210T3 (es)
EA (1) EA032195B1 (es)
ES (1) ES2669543T3 (es)
HU (1) HUE038261T2 (es)
MX (1) MX359040B (es)
PH (1) PH12016500092B1 (es)
PL (1) PL3022210T3 (es)
TR (1) TR201806860T4 (es)
TW (1) TW201546076A (es)
UY (1) UY35668A (es)
WO (1) WO2015007669A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3187498A4 (en) 2014-08-27 2018-01-17 Shionogi & Co., Ltd. Azaindole derivative having ampk-activating effect
JPWO2016068099A1 (ja) 2014-10-28 2017-08-10 塩野義製薬株式会社 Ａｍｐｋ活性化作用を有する複素環誘導体
US10053471B2 (en) * 2015-01-16 2018-08-21 Boehringer Ingelheim International Gmbh Azabenzimidazole derivatives
CN109071536A (zh) 2016-02-26 2018-12-21 盐野义制药株式会社 具有ampk活化作用的5-苯基氮杂吲哚衍生物
CN109476661A (zh) * 2016-05-20 2019-03-15 盐野义制药株式会社 具有ampk活化作用的5-取代苯并咪唑及5-取代氮杂苯并咪唑衍生物
BR112021007101A2 (pt) * 2018-10-15 2021-07-27 Gero Discovery Limited Liability Company composto, composto para uso como neuroprotetor, sal de adição de ácido farmaceuticamente aceitável, derivado, n-óxido, solvato, tautômero, estereoisômero, racemato, sal fisiologicamente aceitável, composição farmacêutica, composições farmacêuticas neuroprotetiva e antienvelhecimento, meio tangível, agente de deleção, diminuição, ligação, inibição ou degradação de pfkfb3, inibidores de pfkfb3, de pfkfb3 para uso em neuroproteção, de atividade de quinase de pfkfb3 de molécula pequena, de atividade de quinase de pfkfb3, de molécula pequena de pfkfb3 e de molécula pequena de atividade de quinase de pfkfb3, kits para tratamento de um quadro mediado por pfkfb3 e/ou pfkfb4, de um câncer, para tratamento antienvelhecimento e para neuroproteção, métodos de imunossupressão e para tratamento de um câncer, de tumor sólido, de um câncer hematológico, de um câncer ósseo, de osteosarcoma, de doença, de isquemia cerebral, de derrame isquêmico neonatal, de insulto neurológico, de derrame isquêmico, de envelhecimento acelerado de sobrevivente de câncer, de envelhecimento acelerado de indivíduo sofrendo de hiv, de uma lesão traumática no cérebro, de um indivíduo humano após lesão no sistema nervoso central aguda, para o tratamento de um transtorno associado à modulação de níveis f-2,6-p2 em um mamífero, para tratamento ou prevenção de um transtorno ou doença relacionada à idade ou outro tratamento antienvelhecimento e para prevenção ou tratamento de consequências da quimioterapia e da radioterapia, para tratamento ou profilaxia de doença ou quadro no qual a inibição de glicólise tem efeito benéfico, de doença neurodegenerativa ou quadro no qual a inibição de glicólise tem efeito benéfico e de doença neurodegenerativa ou quadro neurodegenerativo, para intensificar o efeito de tratamento de câncer por radiação, o efeito de tratamento de câncer ósseo por radiação e o efeito de tratamento de osteosarcoma por radiação, para reduzir a capacidade de as células cancerosas repararem seu dna e reduzir inflamação aterosclerótica e/ou pelo menos uma de suas consequências clínicas, para sensibilizar a célula cancerosa para a terapia citostática e/ou de radiação, e, métodos para neuroproteção, para fabricação de uma medicação, para fabricação de uma medicação de neuroproteção, para aumento de capacidade antioxidante de célula, para reduzir uma absorção glicolítica no neurônio, para prevenção de morte apoptótica do neurônio, para reduzir uma absorção glicolítica no astrócito, para inibição reativa à proliferação de astrócito, para proteção de um neurônio contra a excitotoxicidade, para proteção de um neurônio entérico contra a excitotoxicidade, para atenuação ou prevenção de dano neuronal em um indivíduo humano, para prevenção ou tratamento de doença relacionada ao envelhecimento, para melhoria de um parâmetro, para rejuvenescimento, para radioproteção, para a mudança de biomarcador ou biomarcadores de mortalidade, para a mudança de biomarcador ou biomarcadores de longevidade ou
AR120377A1 (es) 2019-11-11 2022-02-09 Pi Industries Ltd Derivados heteroaromáticos de sulfiliminas o sulfoximinas con actividad fungicida
JP2023526625A (ja) 2020-05-19 2023-06-22 キャリーオペ，インク． Ａｍｐｋアクチベーター
JP2023531726A (ja) 2020-06-26 2023-07-25 キャリーオペ，インク． Ａｍｐｋアクチベーター
WO2024169952A1 (en) 2023-02-16 2024-08-22 Gasherbrum Bio, Inc. Heterocyclic glp-1 agonists

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Publication number Priority date Publication date Assignee Title
CN101511429A (zh) * 2006-07-13 2009-08-19 史密丝克莱恩比彻姆公司 二氢吲哚衍生物和gpr119激动剂
MX337714B (es) 2010-09-10 2016-03-16 Shionogi & Co Derivado de imidazol de heteroanillo fusionado que tiene efecto de activacion de proteina cinasa activada por monofosfato de adenosina (amk).
SG192941A1 (en) * 2011-02-25 2013-09-30 Merck Sharp & Dohme Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agents
EP2887807B1 (en) * 2012-08-22 2019-09-18 Merck Sharp & Dohme Corp. Benzimidazole hexahydrofuro[3,2-b]furan derivatives useful as amp-activated protein kinase activators
EP2888005B1 (en) * 2012-08-22 2019-04-03 Merck Sharp & Dohme Corp. Novel azabenzimidazole hexahydrofuro[3,2-b]furan derivatives
WO2014069426A1 (ja) * 2012-10-31 2014-05-08 塩野義製薬株式会社 Ａｍｐｋ活性化作用を有するベンズイミダゾールおよびアザベンズイミダゾール誘導体

Also Published As

Publication number Publication date
TW201546076A (zh) 2015-12-16
CN105377857A (zh) 2016-03-02
US20150025065A1 (en) 2015-01-22
JP6491656B2 (ja) 2019-03-27
EP3022210A1 (en) 2016-05-25
TR201806860T4 (tr) 2018-06-21
WO2015007669A1 (en) 2015-01-22
EA032195B1 (ru) 2019-04-30
ES2669543T3 (es) 2018-05-28
PL3022210T3 (pl) 2018-08-31
MX359040B (es) 2018-09-13
US9492436B2 (en) 2016-11-15
EP3022210B1 (en) 2018-02-21
PH12016500092A1 (en) 2016-04-18
UY35668A (es) 2015-01-30
KR20160033749A (ko) 2016-03-28
HUE038261T2 (hu) 2018-10-29
PH12016500092B1 (en) 2019-04-12
CA2918401A1 (en) 2015-01-22
CN105377857B (zh) 2018-04-10
DK3022210T3 (en) 2018-06-06
AU2014292236B2 (en) 2018-11-08
AR096936A1 (es) 2016-02-10
MX2016000547A (es) 2016-04-20
AU2014292236A1 (en) 2016-01-21
EA201600113A1 (ru) 2016-07-29
JP2016527223A (ja) 2016-09-08

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