CL2013002234A1 - Uso de una composicion farmaceutica que comprende al menos una prostaciclina o un analogo de la misma seleccionado entre treprostinil, ilorpost, cicaprost o beraprost, y al menos un inhibidor de fosfodiesterasa 4 (pde4), porque sirve en la prevencion o tratamiento de la fibrosis quistica. - Google Patents
Uso de una composicion farmaceutica que comprende al menos una prostaciclina o un analogo de la misma seleccionado entre treprostinil, ilorpost, cicaprost o beraprost, y al menos un inhibidor de fosfodiesterasa 4 (pde4), porque sirve en la prevencion o tratamiento de la fibrosis quistica.Info
- Publication number
- CL2013002234A1 CL2013002234A1 CL2013002234A CL2013002234A CL2013002234A1 CL 2013002234 A1 CL2013002234 A1 CL 2013002234A1 CL 2013002234 A CL2013002234 A CL 2013002234A CL 2013002234 A CL2013002234 A CL 2013002234A CL 2013002234 A1 CL2013002234 A1 CL 2013002234A1
- Authority
- CL
- Chile
- Prior art keywords
- prostacyclin
- phosphodiesterase
- inhibitor
- prevention
- treatment
- Prior art date
Links
- 201000003883 Cystic fibrosis Diseases 0.000 title abstract 2
- 229960001123 epoprostenol Drugs 0.000 title abstract 2
- KAQKFAOMNZTLHT-VVUHWYTRSA-N epoprostenol Chemical compound O1C(=CCCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@@H]21 KAQKFAOMNZTLHT-VVUHWYTRSA-N 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 230000002265 prevention Effects 0.000 title abstract 2
- MSYGAHOHLUJIKV-UHFFFAOYSA-N 3,5-dimethyl-1-(3-nitrophenyl)-1h-pyrazole-4-carboxylic acid ethyl ester Chemical compound CC1=C(C(=O)OCC)C(C)=NN1C1=CC=CC([N+]([O-])=O)=C1 MSYGAHOHLUJIKV-UHFFFAOYSA-N 0.000 title 1
- 101100296719 Caenorhabditis elegans pde-4 gene Proteins 0.000 title 1
- 102000011017 Type 4 Cyclic Nucleotide Phosphodiesterases Human genes 0.000 title 1
- 108010037584 Type 4 Cyclic Nucleotide Phosphodiesterases Proteins 0.000 title 1
- 229960002890 beraprost Drugs 0.000 title 1
- CTPOHARTNNSRSR-APJZLKAGSA-N beraprost Chemical compound O([C@H]1C[C@@H](O)[C@@H]([C@@H]21)/C=C/[C@@H](O)C(C)CC#CC)C1=C2C=CC=C1CCCC(O)=O CTPOHARTNNSRSR-APJZLKAGSA-N 0.000 title 1
- ARUGKOZUKWAXDS-SEWALLKFSA-N cicaprost Chemical compound C1\C(=C/COCC(O)=O)C[C@@H]2[C@@H](C#C[C@@H](O)[C@@H](C)CC#CCC)[C@H](O)C[C@@H]21 ARUGKOZUKWAXDS-SEWALLKFSA-N 0.000 title 1
- 229950000634 cicaprost Drugs 0.000 title 1
- -1 ilorpost Chemical compound 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 229960005032 treprostinil Drugs 0.000 title 1
- PAJMKGZZBBTTOY-ZFORQUDYSA-N treprostinil Chemical compound C1=CC=C(OCC(O)=O)C2=C1C[C@@H]1[C@@H](CC[C@@H](O)CCCCC)[C@H](O)C[C@@H]1C2 PAJMKGZZBBTTOY-ZFORQUDYSA-N 0.000 title 1
- 102000004861 Phosphoric Diester Hydrolases Human genes 0.000 abstract 2
- 108090001050 Phosphoric Diester Hydrolases Proteins 0.000 abstract 2
- 150000003815 prostacyclins Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
- A61K31/37—Coumarins, e.g. psoralen
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
-
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
-
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5578—Eicosanoids, e.g. leukotrienes or prostaglandins having a pentalene ring system, e.g. carbacyclin, iloprost
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/558—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes
- A61K31/5585—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes having five-membered rings containing oxygen as the only ring hetero atom, e.g. prostacyclin
-
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
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- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
La presente invención se refiere al uso de una composición que comprende al menos una prostaciclina o análogo de prostaciclina o una sal farmacéuticamente aceptable de la misma y al menos un inhibidor de fosfodiesterasa (PDE) 4 para la prevención o tratamiento de fibrosis quística por aumentar selectivemnete los niveles de AMPc en células broncoepiteliales.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11153541 | 2011-02-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2013002234A1 true CL2013002234A1 (es) | 2014-01-03 |
Family
ID=43799687
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2013002234A CL2013002234A1 (es) | 2011-02-07 | 2013-08-05 | Uso de una composicion farmaceutica que comprende al menos una prostaciclina o un analogo de la misma seleccionado entre treprostinil, ilorpost, cicaprost o beraprost, y al menos un inhibidor de fosfodiesterasa 4 (pde4), porque sirve en la prevencion o tratamiento de la fibrosis quistica. |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US9504663B2 (es) |
| EP (1) | EP2672957B1 (es) |
| JP (2) | JP5997182B2 (es) |
| KR (1) | KR101852222B1 (es) |
| CN (1) | CN103391766B (es) |
| AU (1) | AU2012215606B2 (es) |
| BR (1) | BR112013019335B1 (es) |
| CA (1) | CA2826183C (es) |
| CL (1) | CL2013002234A1 (es) |
| CY (1) | CY1119999T1 (es) |
| DK (1) | DK2672957T3 (es) |
| EA (1) | EA029760B1 (es) |
| ES (1) | ES2612510T3 (es) |
| HR (1) | HRP20170113T1 (es) |
| HU (1) | HUE031652T2 (es) |
| IL (1) | IL227738B (es) |
| LT (1) | LT2672957T (es) |
| ME (1) | ME02598B (es) |
| PL (1) | PL2672957T3 (es) |
| PT (1) | PT2672957T (es) |
| RS (1) | RS55624B1 (es) |
| SG (1) | SG192677A1 (es) |
| SI (1) | SI2672957T1 (es) |
| SM (2) | SMT201700099T1 (es) |
| UA (1) | UA113161C2 (es) |
| WO (1) | WO2012107363A1 (es) |
| ZA (1) | ZA201305276B (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2011013312A (es) | 2009-06-12 | 2012-01-25 | Mankind Corp | Microparticulas de dicetopiperazina con areas de superficie especificas definidas. |
| US9505737B2 (en) | 2013-01-11 | 2016-11-29 | Corsair Pharma, Inc. | Treprostinil derivative compounds and methods of using same |
| ES2805367T3 (es) | 2013-01-11 | 2021-02-11 | Corsair Pharma Inc | Profármacos de treprostinil |
| WO2014144895A1 (en) | 2013-03-15 | 2014-09-18 | Mannkind Corporation | Microcrystalline diketopiperazine compositions and methods |
| EP3021834A1 (en) | 2013-07-18 | 2016-05-25 | MannKind Corporation | Heat-stable dry powder pharmaceutical compositions and methods |
| US9643911B2 (en) | 2015-06-17 | 2017-05-09 | Corsair Pharma, Inc. | Treprostinil derivatives and compositions and uses thereof |
| US9394227B1 (en) | 2015-06-17 | 2016-07-19 | Corsair Pharma, Inc. | Treprostinil derivatives and compositions and uses thereof |
| CN111108109A (zh) | 2017-09-20 | 2020-05-05 | 利奥制药有限公司 | 取代的二氢噻吩并嘧啶及其作为磷酸二酯酶抑制剂的用途 |
| EP3498283A1 (en) | 2017-12-14 | 2019-06-19 | Ipsol AG | Glycosidic derivatives of treprostinil |
| WO2019115776A1 (en) * | 2017-12-15 | 2019-06-20 | Leo Pharma A/S | Substituted azetidine dihydrothienopyridines and their use as phosphodiesterase inhibitors |
| CN118903419A (zh) * | 2020-02-10 | 2024-11-08 | 广州市妇女儿童医疗中心 | Pde抑制剂或其盐在制备用于预防和/或治疗胃肠道疾病的药物中的用途 |
| EP4255418A1 (en) * | 2020-12-01 | 2023-10-11 | Reverspah LLC | Methods and compositions for treating chronic obstructive pulmonary disease, asthma, pneumonia, bronchitis, cystic fibrosis and pulmonary edema |
| CA3206115A1 (en) * | 2021-01-29 | 2022-08-04 | Kazuko Matsuda | Methods of treating chemical gas exposure |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999018099A1 (en) | 1997-10-03 | 1999-04-15 | Merck Frosst Canada & Co. | Aryl thiophene derivatives as pde iv inhibitors |
| US6020339A (en) * | 1997-10-03 | 2000-02-01 | Merck & Co., Inc. | Aryl furan derivatives as PDE IV inhibitors |
| WO2000002450A1 (en) | 1998-07-08 | 2000-01-20 | Fibrogen, Inc. | Method for treatment of fibrosis related diseases by the administration of prostacyclin derivatives |
| JP2002537383A (ja) * | 1999-02-25 | 2002-11-05 | メルク フロスト カナダ アンド カンパニー | Ｐｄｅｉｖ阻害化合物、組成物および治療方法 |
| US6436965B1 (en) * | 2000-03-02 | 2002-08-20 | Merck Frosst Canada & Co. | PDE IV inhibiting amides, compositions and methods of treatment |
| CN1503792A (zh) | 2001-04-25 | 2004-06-09 | ��̹��ҽҩ��˾ | 新的酞嗪酮 |
| JP4786866B2 (ja) | 2001-08-31 | 2011-10-05 | スキャンポ・アーゲー | クロライドチャンネルオープナーとしてのプロスタグランジンアナログ |
| MY140561A (en) | 2002-02-20 | 2009-12-31 | Nycomed Gmbh | Dosage form containing pde 4 inhibitor as active ingredient |
| TWI347845B (en) | 2002-03-06 | 2011-09-01 | Nycomed Gmbh | Pharmaceutical compositions,combinations,and kits for the treatment of respiratory diseases and use of the same |
| US20060083714A1 (en) | 2003-01-27 | 2006-04-20 | Warner James M | Combination of a pde iv inhibitor and a tnf-alpha antagonist |
| US20050101608A1 (en) | 2003-09-24 | 2005-05-12 | Santel Donald J. | Iloprost in combination therapies for the treatment of pulmonary arterial hypertension |
| CN101090714A (zh) * | 2004-07-26 | 2007-12-19 | 康泽里克斯公司 | 通过吸入伊洛前列素和微粒制剂治疗肺动脉高血压症 |
| US20080096915A1 (en) * | 2005-01-13 | 2008-04-24 | Greenberg Traurig LLP | Compositions for the treatment of metabolic disorders |
| DE102005016345A1 (de) | 2005-04-09 | 2006-10-12 | Bayer Healthcare Ag | Neue Verwendung von 2-Phenyl-substituierten Imidazotriazinon-Derivaten |
| US7893050B2 (en) * | 2005-10-26 | 2011-02-22 | Asahi Kasei Pharma Corporation | Fasudil in combination therapies for the treatment of pulmonary arterial hypertension |
| US8084221B2 (en) | 2006-04-01 | 2011-12-27 | Saint Louis University | Method of screening for a drug candidate that increases ATP release from RBCs stimulated via the Gs or Gi pathway |
| FR2903693B1 (fr) | 2006-07-17 | 2012-03-30 | Inst Nat Polytech Grenoble | Sulfinates et halogenures de sulfonyle aromatiques, et leur preparation. |
| US20090325976A1 (en) | 2006-12-21 | 2009-12-31 | Concert Pharmaceuticals Inc. | Prostacyclin derivatives |
| AU2007338701A1 (en) | 2006-12-21 | 2008-07-03 | Concert Pharmaceuticals Inc. | Prostacyclin derivatives |
| EP2120961A1 (en) * | 2007-02-09 | 2009-11-25 | United Therapeutics Corporation | Treprostinil treatment for interstitial lung disease and asthma |
| WO2008130619A2 (en) * | 2007-04-20 | 2008-10-30 | Trustees Of Boston College | A composition comprising an inhibitor of pde4 and/or pde7 |
| EP2408446B1 (en) | 2009-03-20 | 2019-09-11 | HG&H Pharmaceuticals (Pty) Limited | Use of pharmaceutical compositions containing mesembrenone |
| PT2461812E (pt) | 2009-08-07 | 2014-04-07 | Scipharm S Rl | Composição para o tratamento da fibrose cística |
| EP2338520A1 (de) | 2009-12-21 | 2011-06-29 | Ludwig Maximilians Universität | Konjugat mit Zielfindungsligand und dessen Verwendung |
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2012
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- 2012-02-03 SI SI201230837A patent/SI2672957T1/sl unknown
- 2012-02-03 PL PL12704027T patent/PL2672957T3/pl unknown
- 2012-02-03 WO PCT/EP2012/051880 patent/WO2012107363A1/en active Application Filing
- 2012-02-03 EA EA201300892A patent/EA029760B1/ru not_active IP Right Cessation
- 2012-02-03 PT PT127040277T patent/PT2672957T/pt unknown
- 2012-02-03 BR BR112013019335-2A patent/BR112013019335B1/pt active IP Right Grant
- 2012-02-03 LT LTEP12704027.7T patent/LT2672957T/lt unknown
- 2012-02-03 ME MEP-2017-20A patent/ME02598B/me unknown
- 2012-02-03 CA CA2826183A patent/CA2826183C/en active Active
- 2012-02-03 JP JP2013552912A patent/JP5997182B2/ja not_active Expired - Fee Related
- 2012-02-03 SG SG2013060256A patent/SG192677A1/en unknown
- 2012-02-03 SM SM20170099T patent/SMT201700099T1/it unknown
- 2012-02-03 EP EP12704027.7A patent/EP2672957B1/en active Active
- 2012-02-03 DK DK12704027.7T patent/DK2672957T3/da active
- 2012-02-03 AU AU2012215606A patent/AU2012215606B2/en active Active
- 2012-02-03 ES ES12704027.7T patent/ES2612510T3/es active Active
- 2012-02-03 HU HUE12704027A patent/HUE031652T2/en unknown
- 2012-02-03 US US13/982,399 patent/US9504663B2/en active Active
- 2012-02-03 RS RS20170074A patent/RS55624B1/sr unknown
- 2012-02-03 KR KR1020137022407A patent/KR101852222B1/ko active Active
- 2012-03-02 UA UAA201310727A patent/UA113161C2/uk unknown
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2013
- 2013-07-12 ZA ZA2013/05276A patent/ZA201305276B/en unknown
- 2013-07-31 IL IL227738A patent/IL227738B/en active IP Right Grant
- 2013-08-05 CL CL2013002234A patent/CL2013002234A1/es unknown
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2016
- 2016-07-05 JP JP2016133092A patent/JP2016199574A/ja active Pending
-
2017
- 2017-01-20 CY CY20171100086T patent/CY1119999T1/el unknown
- 2017-01-24 HR HRP20170113TT patent/HRP20170113T1/hr unknown
- 2017-02-14 SM SM201700099T patent/SMT201700099B/it unknown
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