CH676412A5

CH676412A5 -

Info

Publication number: CH676412A5
Application number: CH26988A
Authority: CH
Inventors: Serge Andre Leuthold
Original assignee: Serge Andre Leuthold
Priority date: 1988-01-27
Filing date: 1988-01-27
Publication date: 1991-01-31
Also published as: WO1989006904A1; CA1312006C; EP0352316A1

Abstract

An insect repellent composition contains an agent which amplifies the repellent effects of the active ingredients, and a vinyl placticizing agent. Said composition is characterized in that it contains 30 to 75 wt. % of 95 % ethanol, 5 to 50 wt. % of N,N diéthyl-m-toluamide, 0.1 to 2 wt. % of polyvinylpyrrolidone, 2 to 10 % of isopropyl myristate, 2 to 10 wt. % of dipropylene glycol, 0.1 to 2.5 wt. % of amplifying agent, 0.1 to 2.5 wt. % of a solubilizing homogenizing agent, and 0.1 to 2.5 wt. % of natural repellent extracts.

Description

       

  
 



  La présente invention a pour objet une composition répulsive pour insectes destinée à être appliquée sur la peau humaine tout aussi bien que sur les cheveux, ou vêtement, ainsi que sur le pelage des animaux. 



  L'invention a pour but de procurer une composition répulsive pour insectes qui permet de remédier aux principaux inconvénients présentés par les compositions répulsives connues; à savoir: odeur désagréable et durée d'efficacité limitée soit par absorption ou métabolisation de la composition par la peau, soit par la transpiration due aux fortes chaleurs ou à des efforts ou encore par l'abrasion de la composition occasionnée notamment par le lavage de la surface traitée ou par le déplacement de l'air sur cette surface. C'est ainsi que l'on  constate des diminutions d'efficacité de l'ordre de 60%, par rapport à une atmosphère exempte de vent, lorsque le vent atteint une vitesse de 190 m/minute. 



  A cet effet, la composition suivant l'invention comprend au moins un agent répulsif actif, choisi parmi les extraits de pelargonium, géranium, lavande, pyrèthre, fleur de citronnier, ainsi que du N,N-diethyl-m-toluamide, un agent plastifiant et un agent amplificateur de l'effet répulsif des susdits composés actifs. 



  Suivant une forme de réalisation de l'invention, l'agent plastifiant est un composé vinylique. 



  Suivant une forme de réalisation avantageuse, le composé vinylique est de la polyvinylpyrrolidone. 



  Suivant un mode de réalisation avantageux de l'invention, l'agent amplificateur est cyclopentane-1-one-2-npentane-3-methyl ethyl ester connu sous le nom d'Hedione. 



  Suivant un mode de réalisation particulièrement avantageux de l'invention, la composition comprend, en poids, de 30 à 75% d'éthanol à 95%, de 5 à 50% de N,N-diethyl-m-toluamide, de 0,1 à 2% de polyvinylpyrrolidone, de 2 à 10% de myristate d'isopropyle, de 2 à 10% de dipropylène glycol, de 0,1 à 2,5% d'amplificateur, de 0,1 à 2,5% d'un agent d'homogénéisation solubilisant et d'extraits naturels de 0,1 à 2,5%. 



  D'autres détails et particularités de l'invention ressortiront de la description donnée ci-après, à titre d'exemples non limitatifs, de composition répulsives pour insectes suivant l'invention. 



  La composition suivant l'invention, qui est répulsive pour la plupart des insectes et notamment pour les moustiques suivants: Aedes Aegypti, Culex, Mansonia, Anopheles, Psorophora, pour les puces, les tiques, les taons, les mouches noires, les mouches d'étable, les Cerotopogonidae, a pour caractéristique principale de permettre la création, sur les surfaces couvertes et principalement sur la peau où les compositions répulsives perdent le plus rapidement leur efficacité à cause de l'absorption, la métabolisation, la transpiration et/ou l'abrasion, d'un film, qui résiste au temps, aux conditions extérieures ainsi qu'aux modifications de l'état de la surface couverte et qui régularise et freine sa libération des ingrédients actifs de la composition, dans laquel restent présents la majeure partie de ces ingrédients répulsifs actifs,

    ingrédients dont l'activité est avantageusement accrue par l'incorporation dans la composition d'un amplificateur, ladite composition présentant en outre l'avantage d'être constituée en majeure partie de produits naturels non toxiques pour l'homme et les animaux. 



  Cette composition, dont l'odeur est agréable et qui contient, suivant l'invention et comme décrit ci-après, un agent plastifiant et fixant ainsi qu'un agent amplificateur, a une réelle activité répulsive pendant une période minimal de 4 à 8 heures qui pourrait atteindre 14 heures suivant les conditions externes lorsqu'elle est appliquée dans les quantités suivantes, qui varient notamment suivant les conditions atmosphériques extérieures, telles que la température dont la hausse provoque  la dispersion ou l'abrasion; de 0,05 à 0,2 mg par cm<2> sur la peau et de 0,01 à 0,1 mg/cm<2> sur les cheveux ou les habits et sur le pelage des animaux. 



  Ladite composition, qui contient de la polyvinylpyrrolidone, qui constitue l'agent plastifiant et fixant pour la formation du film susdit, des extraits répulsifs actifs naturels, tels que pelargonium, géranium, lavande, pyrèthre, fleurs de citronnier, ainsi que du N,N-diethyl-m-toluamide, un amplificateur constitué par cyclopentane-1-one-2-npentane-3-methyl ethyl ester dont la propriété est d'assurer un effet de synergie avec les extraits répulsifs actifs, comprend avantageusement, en poids, de 30 à 75% d'éthanol à 95%, de 5 à 50% de N,N-diéthyl-m-toluamide de 0,4 à 2% de polyvinylpyrrolidone, de 2 à 10% de myristate d'isopropyle, de 2 à 10% de dipropylène glycol, de 0,1 à 2,5% de l'amplificateur susdit et de 0,1 à 2,5% d'un agent d'homogénéisation solubilisant, tel que du polyoxyéthylène nonyl phényl éther connu sous le nom de "Lamacite" et de 0,1 à 2,5% d'extraits naturels répulsifs.

  La composition susdite peut également comprendre un colorant améliorant son aspect, ce colorant, introduit dans la composition à raison de 0,001% à 0,01% en poids, étant choisi parmi les colorants neutres par rapport aux constituants susdits. 



  On a obtenu d'excellents résultats répulsifs des insectes, et en particulier des résultats durables, avec une composition comprenant, en poids, 65,5% d'éthanol à 95%, 20% de  N,N-diéthyl-m-toluamide, 1% de polyvinylpyrrolidone, 8% de myristate d'isopropyle, 4% de dipropylène glycol, 0,1% d'agent amplificateur, 0,5% d'agent d'homogénéisation solubilisant et 0,9% d'extrait répulsifs naturels. 



  Suivant l'invention, la composition répulsive peut se présenter soit sous la forme d'un aérosol, soit sous la forme d'un gel pouvant être notamment utilisé dans un distributeur à tête de distribution à bille (roll-on) ou encore sous forme de spray. 



  Quand elle se présente sous la forme d'aérosol, on utilise comme gaz propulseur.
 - soit un mélange de 90% en volume de isobutane et de 10% en volume de propane, tel qu'il est connue sous le nom "Drivosol 27", à raison de 20 à 25% en poids;
 - soit un mélange de propane et de  butane  à raison de 40% en poids. 



  Quand la composition se présente sous la forme d'un gel, elle comprend, en poids, 45 à 55% de la composition définie  ci-dessus, 25 à 35% d'eau déminéralisée, 12,7 à 17,5% d'alcool étylique à 95%, de 0,1 à 1,3% d'un agent d'accroissement de la viscosité, tel qu'un polymère à très haut poids moléculaire connu sous le nom de "carbomère", de 1,5% à 4,5% d'huile de foie de morue hydrogénée, connu notamment sous le nom de "Crémophor 2H40" et de 0,5 à 2% de polyoxyéthylène (15) cocoamine connu sous le nom d'"Ethomeen C/25". 



    On a obtenu une excellente composition, sous forme de gel stable, avec 49,5% de la composition définie ci-avant, 30% d'eau déminéralisée, 15,5% d'alcool éthylique à 95%, 1% de "Carbomère", 3% de "Crémophor 2H40" et 1% d'"Ethomeen C/25". Lorsque ce gel est destiné à être utilisé dans un distributeur à tête de distribution a bille (roll-on), on abaisse la viscosité du gel défini ci-dessus en augmentant la quantité de solvant. 



  Lorsqu'elle est présentée en spray, la composition est avantageusement celle qui est définie ci-dessus, et plus particulièrement celle qui comprend 65,5% d'éthanol à 95%, 20% de N,N-diéthyl-m-toluamide, 1% de polyvinylpyrrolidone, 8% de myristate d'isopropyle, 4% de dipropylène glycol, 0,1% d'amplificateur, 0,5% d'agent d'homogénéisation solubilisant et 0,9% d'extraits répulsifs naturels. 



  
 



  The subject of the present invention is an insect repellant composition intended to be applied to human skin as well as to hair, or clothing, as well as to the coat of animals.



  The object of the invention is to provide an insect repellent composition which makes it possible to remedy the main drawbacks presented by known repellent compositions; namely: unpleasant odor and limited duration of effectiveness either by absorption or metabolization of the composition by the skin, or by sweating due to high heat or stress or by abrasion of the composition caused in particular by washing of the treated surface or by the movement of air on this surface. This is how we notice efficiency reductions of around 60%, compared to a wind-free atmosphere, when the wind reaches a speed of 190 m / minute.



  To this end, the composition according to the invention comprises at least one active repellant, chosen from extracts of pelargonium, geranium, lavender, pyrethrum, lemon flower, as well as N, N-diethyl-m-toluamide, an agent plasticizer and an agent amplifying the repellent effect of the above active compounds.



  According to one embodiment of the invention, the plasticizing agent is a vinyl compound.



  According to an advantageous embodiment, the vinyl compound is polyvinylpyrrolidone.



  According to an advantageous embodiment of the invention, the amplifying agent is cyclopentane-1-one-2-npentane-3-methyl ethyl ester known under the name of Hedione.



  According to a particularly advantageous embodiment of the invention, the composition comprises, by weight, from 30 to 75% of 95% ethanol, from 5 to 50% of N, N-diethyl-m-toluamide, from 0, 1 to 2% polyvinylpyrrolidone, 2 to 10% isopropyl myristate, 2 to 10% dipropylene glycol, 0.1 to 2.5% amplifier, 0.1 to 2.5% d '' a solubilizing homogenizing agent and natural extracts from 0.1 to 2.5%.



  Other details and particularities of the invention will emerge from the description given below, by way of nonlimiting examples, of insect repellents according to the invention.



  The composition according to the invention, which is repellent for most insects and in particular for the following mosquitoes: Aedes Aegypti, Culex, Mansonia, Anopheles, Psorophora, for fleas, ticks, horse flies, black flies, black flies stable, Cerotopogonidae, has the main characteristic of allowing the creation, on covered surfaces and mainly on the skin where the repellant compositions lose their effectiveness as quickly as possible due to absorption, metabolization, perspiration and / or l abrasion, of a film, which resists time, external conditions as well as changes in the state of the covered surface and which regulates and slows its release from the active ingredients of the composition, in which most of the present remains of these active repellant ingredients,

    ingredients whose activity is advantageously increased by the incorporation into the composition of an enhancer, said composition further having the advantage of being made up for the most part of natural products which are non-toxic for humans and animals.



  This composition, the odor of which is pleasant and which, according to the invention and as described below, contains a plasticizing and fixing agent as well as an amplifying agent, has real repulsive activity for a minimum period of 4 to 8 hours. which could reach 14 hours depending on external conditions when it is applied in the following quantities, which vary in particular according to external atmospheric conditions, such as the temperature whose rise causes dispersion or abrasion; from 0.05 to 0.2 mg per cm <2> on the skin and from 0.01 to 0.1 mg / cm <2> on the hair or clothing and on the coats of animals.



  Said composition, which contains polyvinylpyrrolidone, which constitutes the plasticizing and fixing agent for the formation of the abovementioned film, natural active repellent extracts, such as pelargonium, geranium, lavender, pyrethrum, lemon flowers, as well as N, N -diethyl-m-toluamide, an amplifier constituted by cyclopentane-1-one-2-npentane-3-methyl ethyl ester whose property is to ensure a synergistic effect with the active repellent extracts, advantageously comprises, by weight, 30 to 75% 95% ethanol, 5 to 50% N, N-diethyl-m-toluamide from 0.4 to 2% polyvinylpyrrolidone, 2 to 10% isopropyl myristate, 2 to 10% dipropylene glycol, 0.1 to 2.5% of the above-mentioned enhancer and 0.1 to 2.5% of a solubilizing homogenizing agent, such as polyoxyethylene nonyl phenyl ether known under the name of "Lamacite" and from 0.1 to 2.5% of natural repellent extracts.

  The aforementioned composition may also comprise a dye improving its appearance, this dye, introduced into the composition in an amount of 0.001% to 0.01% by weight, being chosen from neutral dyes with respect to the above-mentioned constituents.



  Excellent insect repellency results have been obtained, and in particular lasting results, with a composition comprising, by weight, 65.5% of 95% ethanol, 20% of N, N-diethyl-m-toluamide, 1% polyvinylpyrrolidone, 8% isopropyl myristate, 4% dipropylene glycol, 0.1% amplifying agent, 0.5% solubilizing homogenizing agent and 0.9% natural repellents extract.



  According to the invention, the repellent composition can be either in the form of an aerosol, or in the form of a gel which can in particular be used in a dispenser with a roll-on dispensing head or even in the form of spray.



  When it is in the form of an aerosol, it is used as a propellant.
 - Or a mixture of 90% by volume of isobutane and 10% by volume of propane, as it is known by the name "Drivosol 27", at a rate of 20 to 25% by weight;
 - or a mixture of propane and butane at a rate of 40% by weight.



  When the composition is in the form of a gel, it comprises, by weight, 45 to 55% of the composition defined above, 25 to 35% of demineralized water, 12.7 to 17.5% of 95% ethyl alcohol, 0.1 to 1.3% of a viscosity-enhancing agent, such as a very high molecular weight polymer known as a "carbomer", of 1.5% with 4.5% hydrogenated cod liver oil, known in particular under the name of "Crémophor 2H40" and from 0.5 to 2% of polyoxyethylene (15) cocoamine known under the name of "Ethomeen C / 25" .



    An excellent composition was obtained, in the form of a stable gel, with 49.5% of the composition defined above, 30% of demineralized water, 15.5% of 95% ethyl alcohol, 1% of "Carbomer ", 3% of" Crémophor 2H40 "and 1% of" Ethomeen C / 25 ". When this gel is intended to be used in a dispenser with a roll-on dispensing head, the viscosity of the gel defined above is lowered by increasing the amount of solvent.



  When it is presented as a spray, the composition is advantageously that which is defined above, and more particularly that which comprises 65.5% of 95% ethanol, 20% of N, N-diethyl-m-toluamide, 1% polyvinylpyrrolidone, 8% isopropyl myristate, 4% dipropylene glycol, 0.1% enhancer, 0.5% solubilizing homogenizing agent and 0.9% natural repellents.

Claims

1. insect repellant composition intended to be applied to human skin as well as to hair and clothing, as well as to the coat of animals, characterized in that it comprises at least one active repellent extract, chosen from extracts of pelargonium, geranium, lavender, pyrethrum, lemon flower, as well as N, N-Diethyl-m-Toluamide, a plasticizing agent and an agent amplifying the repellent effect of said active compounds.

2. Composition according to claim 1, characterized in that the plasticizing agent is a vinyl compound.

3. Composition according to claim 2, characterized in that the vinyl compound is polyvinylpyrrolidone.

4. Composition according to any one of claims 1 to 3, characterized in that the amplifying agent is cyclopentane-1-one-2-npentane-3-methyl ethyl ester.

5.

Composition according to either of Claims 3 and 4, characterized in that it comprises, by weight, from 30 to 75% of 95% ethanol, from 5 to 50% of N, N-diethyl- m-toluamide, 0.1-2% polyvinylpyrrolidone, 2-10% isopropyl myristate, 2-10% dipropylene glycol, 0.1-2.5% enhancer, and 0 , 1 to 2.5% of a solubilizing homogenizing agent and 0.1 to 2.5% of natural repellents extract.

6. Composition according to claim 5, characterized in that, as solubilizing homogenizing agent, polyoxythylene nonyl phenyl ether is used.

7. Composition according to either of Claims 5 and 6, characterized in that it comprises from 0.001% to 0.01% by weight of a neutral dye relative to the above-mentioned constituents.

8.

Composition according to any one of Claims 5 to 7, characterized in that it comprises, by weight, 65.5% of 95% ethanol, 20% of N, N-diethyl-m-toluamide, 1% of polyvinylpyrrolidone, 8% isopropyl myristate, 4% dipropylene glycol, 0.1% enhancer and 0.5% solubilizing homogenizing agent and 0.9% natural repellents.

9. Aerosol, characterized in that it comprises a composition according to any one of claims 1 to 8 and a propellant.

10. Aerosol according to claim 9, characterized in that the propellant a mixture of 90% by volume of isobutane and 10% by volume of propane, in an amount of 20 to 25% by weight.

11. Aerosol according to claim 9, characterized in that the propellant is a mixture of propane and butane, at a rate of 40% by weight.

12.

Gel, characterized in that it comprises, by weight, from 45 to 55% of a composition according to any one of Claims 1 to 8, from 25 to 35% of demineralized water, from 12.7 to 17, 5% 95% ethyl alcohol, 0.1-1.3% viscosity enhancing agent, 1.5-4.5% hydrogenated cod liver oil, and 0.5 to 2% of cocoamine polyoxyethylene (15).

13. Gel according to claim 12, characterized in that the viscosity-increasing agent is a very high molecular weight polymer.

14. Gel according to claim 12, characterized in that it comprises, by weight, 49.5% of a composition according to any one of claims 1 to 8, 30% of demineralized water, 15.5% of alcohol 95% ethyl, 1% viscosity enhancer, 3% hydrogenated cod liver oil, and 1% cocoamine polyoxyethylene (15).

15.

Spray characterized in that it comprises a composition according to any one of claims 1 to 8. 1. insect repellant composition intended to be applied to human skin as well as to hair and clothing, as well as to the coat of animals, characterized in that it comprises at least one active repellent extract, chosen from extracts of pelargonium, geranium, lavender, pyrethrum, lemon flower, as well as N, N-Diethyl-m-Toluamide, a plasticizing agent and an agent amplifying the repellent effect of said active compounds. 2. Composition according to claim 1, characterized in that the plasticizing agent is a vinyl compound. 3. Composition according to claim 2, characterized in that the vinyl compound is polyvinylpyrrolidone. 4. Composition according to any one of claims 1 to 3, characterized in that the amplifying agent is cyclopentane-1-one-2-npentane-3-methyl ethyl ester. 5.

Composition according to either of Claims 3 and 4, characterized in that it comprises, by weight, from 30 to 75% of 95% ethanol, from 5 to 50% of N, N-diethyl- m-toluamide, 0.1-2% polyvinylpyrrolidone, 2-10% isopropyl myristate, 2-10% dipropylene glycol, 0.1-2.5% enhancer, and 0 , 1 to 2.5% of a solubilizing homogenizing agent and 0.1 to 2.5% of natural repellents extract. 6. Composition according to claim 5, characterized in that, as solubilizing homogenizing agent, polyoxythylene nonyl phenyl ether is used. 7. Composition according to either of Claims 5 and 6, characterized in that it comprises from 0.001% to 0.01% by weight of a neutral dye relative to the above-mentioned constituents. 8.

Composition according to any one of Claims 5 to 7, characterized in that it comprises, by weight, 65.5% of 95% ethanol, 20% of N, N-diethyl-m-toluamide, 1% of polyvinylpyrrolidone, 8% isopropyl myristate, 4% dipropylene glycol, 0.1% enhancer and 0.5% solubilizing homogenizing agent and 0.9% natural repellents. 9. Aerosol, characterized in that it comprises a composition according to any one of claims 1 to 8 and a propellant. 10. Aerosol according to claim 9, characterized in that the propellant a mixture of 90% by volume of isobutane and 10% by volume of propane, in an amount of 20 to 25% by weight. 11. Aerosol according to claim 9, characterized in that the propellant is a mixture of propane and butane, at a rate of 40% by weight. 12.

Gel, characterized in that it comprises, by weight, from 45 to 55% of a composition according to any one of Claims 1 to 8, from 25 to 35% of demineralized water, from 12.7 to 17, 5% 95% ethyl alcohol, 0.1-1.3% viscosity enhancing agent, 1.5-4.5% hydrogenated cod liver oil, and 0.5 to 2% of cocoamine polyoxyethylene (15). 13. Gel according to claim 12, characterized in that the viscosity-increasing agent is a very high molecular weight polymer. 14. Gel according to claim 12, characterized in that it comprises, by weight, 49.5% of a composition according to any one of claims 1 to 8, 30% of demineralized water, 15.5% of alcohol 95% ethyl, 1% viscosity enhancer, 3% hydrogenated cod liver oil, and 1% cocoamine polyoxyethylene (15). 15.

Spray characterized in that it comprises a composition according to any one of claims 1 to 8.