CH651204A5 - Mittel zur foerderung der mundhygiene. - Google Patents

Mittel zur foerderung der mundhygiene. Download PDF

Info

Publication number: CH651204A5
Authority: CH; Switzerland
Prior art keywords: copolymer; composition according; agent; antibacterial anti; units
Prior art date: 1980-12-31

Application number

CH8360/81A

Other languages

German (de)

English (en)

Inventor

Abdul Gaffar

Original Assignee

Colgate Palmolive Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-12-31

Filing date

1981-12-30

Publication date

1985-09-13

1980-12-31 Priority claimed from US06/221,664 external-priority patent/US4339430A/en

1980-12-31 Priority claimed from US06/221,665 external-priority patent/US4339431A/en

1981-12-30 Application filed by Colgate Palmolive Co filed Critical Colgate Palmolive Co

1985-09-13 Publication of CH651204A5 publication Critical patent/CH651204A5/de

Links

229920001577 copolymer Polymers 0.000 claims description 57
239000000203 mixture Substances 0.000 claims description 51
239000003795 chemical substances by application Substances 0.000 claims description 37
230000000844 anti-bacterial effect Effects 0.000 claims description 30
238000002360 preparation method Methods 0.000 claims description 20
OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims description 13
OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims description 13
WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims description 12
235000013922 glutamic acid Nutrition 0.000 claims description 12
239000004220 glutamic acid Substances 0.000 claims description 12
239000000606 toothpaste Substances 0.000 claims description 12
125000004432 carbon atom Chemical group C* 0.000 claims description 11
239000002519 antifouling agent Substances 0.000 claims description 9
UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 claims description 9
239000007788 liquid Substances 0.000 claims description 9
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 8
239000002324 mouth wash Substances 0.000 claims description 8
150000003839 salts Chemical class 0.000 claims description 8
235000004279 alanine Nutrition 0.000 claims description 7
125000000217 alkyl group Chemical group 0.000 claims description 7
229960001950 benzethonium chloride Drugs 0.000 claims description 7
238000000034 method Methods 0.000 claims description 7
QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims description 6
238000005498 polishing Methods 0.000 claims description 6
229940034610 toothpaste Drugs 0.000 claims description 6
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 4
239000012458 free base Substances 0.000 claims description 4
229940051866 mouthwash Drugs 0.000 claims description 4
230000001737 promoting effect Effects 0.000 claims description 4
150000003856 quaternary ammonium compounds Chemical class 0.000 claims description 4
LFVVNPBBFUSSHL-UHFFFAOYSA-N alexidine Chemical compound CCCCC(CC)CNC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NCC(CC)CCCC LFVVNPBBFUSSHL-UHFFFAOYSA-N 0.000 claims description 3
229950010221 alexidine Drugs 0.000 claims description 3
150000002357 guanidines Chemical class 0.000 claims description 3
GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims description 2
229960003260 chlorhexidine Drugs 0.000 claims description 2
239000004615 ingredient Substances 0.000 claims description 2
CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 claims 1
ZRALSGWEFCBTJO-UHFFFAOYSA-N anhydrous guanidine Natural products NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 claims 1
SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 claims 1
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 35
150000001875 compounds Chemical class 0.000 description 28
238000009472 formulation Methods 0.000 description 23
-1 bisbiguanide compounds Chemical class 0.000 description 21
229910052588 hydroxylapatite Inorganic materials 0.000 description 21
XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 21
230000015572 biosynthetic process Effects 0.000 description 20
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 20
208000006558 Dental Calculus Diseases 0.000 description 16
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 16
239000000377 silicon dioxide Substances 0.000 description 15
235000012239 silicon dioxide Nutrition 0.000 description 15
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
125000002091 cationic group Chemical group 0.000 description 12
239000003242 anti bacterial agent Substances 0.000 description 9
210000003298 dental enamel Anatomy 0.000 description 9
239000000463 material Substances 0.000 description 9
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 8
239000001506 calcium phosphate Substances 0.000 description 8
239000013078 crystal Substances 0.000 description 8
239000011734 sodium Substances 0.000 description 8
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 8
239000011575 calcium Substances 0.000 description 7
235000011187 glycerol Nutrition 0.000 description 7
239000002245 particle Substances 0.000 description 7
239000000654 additive Substances 0.000 description 6
229910052783 alkali metal Inorganic materials 0.000 description 6
229910000389 calcium phosphate Inorganic materials 0.000 description 6
235000011010 calcium phosphates Nutrition 0.000 description 6
230000000694 effects Effects 0.000 description 6
239000000843 powder Substances 0.000 description 6
239000007787 solid Substances 0.000 description 6
239000000126 substance Substances 0.000 description 6
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 5
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 5
229910052791 calcium Inorganic materials 0.000 description 5
YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 description 5
229960001927 cetylpyridinium chloride Drugs 0.000 description 5
238000002845 discoloration Methods 0.000 description 5
210000000214 mouth Anatomy 0.000 description 5
229910052708 sodium Inorganic materials 0.000 description 5
239000000600 sorbitol Substances 0.000 description 5
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 4
ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 4
239000002253 acid Substances 0.000 description 4
229940027983 antiseptic and disinfectant quaternary ammonium compound Drugs 0.000 description 4
239000002585 base Substances 0.000 description 4
239000011248 coating agent Substances 0.000 description 4
239000000796 flavoring agent Substances 0.000 description 4
239000000499 gel Substances 0.000 description 4
239000003906 humectant Substances 0.000 description 4
235000011837 pasties Nutrition 0.000 description 4
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 4
229920000642 polymer Polymers 0.000 description 4
150000003512 tertiary amines Chemical class 0.000 description 4
UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 3
239000004354 Hydroxyethyl cellulose Substances 0.000 description 3
ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
229910019142 PO4 Inorganic materials 0.000 description 3
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
230000000996 additive effect Effects 0.000 description 3
150000001340 alkali metals Chemical class 0.000 description 3
239000003945 anionic surfactant Substances 0.000 description 3
230000002272 anti-calculus Effects 0.000 description 3
230000003373 anti-fouling effect Effects 0.000 description 3
238000006243 chemical reaction Methods 0.000 description 3
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
238000000576 coating method Methods 0.000 description 3
229940091249 fluoride supplement Drugs 0.000 description 3
235000003599 food sweetener Nutrition 0.000 description 3
235000019447 hydroxyethyl cellulose Nutrition 0.000 description 3
238000000338 in vitro Methods 0.000 description 3
230000005764 inhibitory process Effects 0.000 description 3
OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 3
239000000178 monomer Substances 0.000 description 3
229910052757 nitrogen Inorganic materials 0.000 description 3
TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 3
239000010452 phosphate Substances 0.000 description 3
235000018102 proteins Nutrition 0.000 description 3
108090000623 proteins and genes Proteins 0.000 description 3
102000004169 proteins and genes Human genes 0.000 description 3
230000002829 reductive effect Effects 0.000 description 3
210000003296 saliva Anatomy 0.000 description 3
AQMNWCRSESPIJM-UHFFFAOYSA-M sodium metaphosphate Chemical compound [Na+].[O-]P(=O)=O AQMNWCRSESPIJM-UHFFFAOYSA-M 0.000 description 3
238000010186 staining Methods 0.000 description 3
125000001424 substituent group Chemical group 0.000 description 3
239000003765 sweetening agent Substances 0.000 description 3
YUOWTJMRMWQJDA-UHFFFAOYSA-J tin(iv) fluoride Chemical compound [F-].[F-].[F-].[F-].[Sn+4] YUOWTJMRMWQJDA-UHFFFAOYSA-J 0.000 description 3
235000002374 tyrosine Nutrition 0.000 description 3
125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 3
IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 description 2
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
108010011485 Aspartame Proteins 0.000 description 2
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
241000894006 Bacteria Species 0.000 description 2
CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 2
101100315624 Caenorhabditis elegans tyr-1 gene Proteins 0.000 description 2
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
229920001479 Hydroxyethyl methyl cellulose Polymers 0.000 description 2
MXRIRQGCELJRSN-UHFFFAOYSA-N O.O.O.[Al] Chemical compound O.O.O.[Al] MXRIRQGCELJRSN-UHFFFAOYSA-N 0.000 description 2
RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 2
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
150000007513 acids Chemical class 0.000 description 2
125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 description 2
229910052782 aluminium Inorganic materials 0.000 description 2
PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 2
150000001412 amines Chemical class 0.000 description 2
QGZKDVFQNNGYKY-UHFFFAOYSA-O ammonium group Chemical group [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 2
125000000129 anionic group Chemical group 0.000 description 2
230000002882 anti-plaque Effects 0.000 description 2
IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 2
WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
230000001680 brushing effect Effects 0.000 description 2
239000001768 carboxy methyl cellulose Substances 0.000 description 2
238000005119 centrifugation Methods 0.000 description 2
238000007334 copolymerization reaction Methods 0.000 description 2
239000002178 crystalline material Substances 0.000 description 2
235000019634 flavors Nutrition 0.000 description 2
235000013355 food flavoring agent Nutrition 0.000 description 2
125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 description 2
239000003112 inhibitor Substances 0.000 description 2
230000002401 inhibitory effect Effects 0.000 description 2
GVALZJMUIHGIMD-UHFFFAOYSA-H magnesium phosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GVALZJMUIHGIMD-UHFFFAOYSA-H 0.000 description 2
238000004519 manufacturing process Methods 0.000 description 2
125000005341 metaphosphate group Chemical group 0.000 description 2
229920000609 methyl cellulose Polymers 0.000 description 2
239000001923 methylcellulose Substances 0.000 description 2
235000010981 methylcellulose Nutrition 0.000 description 2
125000004433 nitrogen atom Chemical group N* 0.000 description 2
239000002736 nonionic surfactant Substances 0.000 description 2
239000003921 oil Substances 0.000 description 2
235000019198 oils Nutrition 0.000 description 2
RARSHUDCJQSEFJ-UHFFFAOYSA-N p-Hydroxypropiophenone Chemical compound CCC(=O)C1=CC=C(O)C=C1 RARSHUDCJQSEFJ-UHFFFAOYSA-N 0.000 description 2
239000008363 phosphate buffer Substances 0.000 description 2
NROKBHXJSPEDAR-UHFFFAOYSA-M potassium fluoride Chemical compound [F-].[K+] NROKBHXJSPEDAR-UHFFFAOYSA-M 0.000 description 2
CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 2
229940081974 saccharin Drugs 0.000 description 2
235000019204 saccharin Nutrition 0.000 description 2
239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 2
PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 2
239000004094 surface-active agent Substances 0.000 description 2
BHHYHSUAOQUXJK-UHFFFAOYSA-L zinc fluoride Chemical compound F[Zn]F BHHYHSUAOQUXJK-UHFFFAOYSA-L 0.000 description 2
LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
DTOUUUZOYKYHEP-UHFFFAOYSA-N 1,3-bis(2-ethylhexyl)-5-methyl-1,3-diazinan-5-amine Chemical compound CCCCC(CC)CN1CN(CC(CC)CCCC)CC(C)(N)C1 DTOUUUZOYKYHEP-UHFFFAOYSA-N 0.000 description 1
RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
PBYSGNVIJLMHLI-UHFFFAOYSA-N 1-[n'-[(4-chlorophenyl)methyl]carbamimidoyl]-2-(3-dodecoxypropyl)guanidine Chemical compound CCCCCCCCCCCCOCCCNC(=N)NC(=N)NCC1=CC=C(Cl)C=C1 PBYSGNVIJLMHLI-UHFFFAOYSA-N 0.000 description 1
GNRHJCJPGSPGHI-UHFFFAOYSA-N 1-[n'-[(4-chlorophenyl)methyl]carbamimidoyl]-2-[(2,4-dichlorophenyl)methyl]guanidine Chemical compound C1=CC(Cl)=CC=C1CNC(=N)NC(=N)NCC1=CC=C(Cl)C=C1Cl GNRHJCJPGSPGHI-UHFFFAOYSA-N 0.000 description 1
HSZNHJJSQQGMDU-UHFFFAOYSA-N 1-carbamimidoyl-1-[(4-chlorophenyl)-phenylmethyl]urea Chemical compound C=1C=C(Cl)C=CC=1C(N(C(=N)N)C(N)=O)C1=CC=CC=C1 HSZNHJJSQQGMDU-UHFFFAOYSA-N 0.000 description 1
OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
DXENBVSHQHBTBD-UHFFFAOYSA-N 2-[(4-chlorophenyl)methyl]-1-(diaminomethylidene)guanidine Chemical compound NC(N)=NC(N)=NCC1=CC=C(Cl)C=C1 DXENBVSHQHBTBD-UHFFFAOYSA-N 0.000 description 1
UBLAMKHIFZBBSS-UHFFFAOYSA-N 3-Methylbutyl pentanoate Chemical compound CCCCC(=O)OCCC(C)C UBLAMKHIFZBBSS-UHFFFAOYSA-N 0.000 description 1
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DDFHBQSCUXNBSA-UHFFFAOYSA-N 5-(5-carboxythiophen-2-yl)thiophene-2-carboxylic acid Chemical compound S1C(C(=O)O)=CC=C1C1=CC=C(C(O)=O)S1 DDFHBQSCUXNBSA-UHFFFAOYSA-N 0.000 description 1
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GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
241000416162 Astragalus gummifer Species 0.000 description 1
239000005711 Benzoic acid Substances 0.000 description 1
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DUSWSURQSVBDKY-UHFFFAOYSA-N ClF.[Sn+2] Chemical compound ClF.[Sn+2] DUSWSURQSVBDKY-UHFFFAOYSA-N 0.000 description 1
229910021593 Copper(I) fluoride Inorganic materials 0.000 description 1
229910021594 Copper(II) fluoride Inorganic materials 0.000 description 1
UDIPTWFVPPPURJ-UHFFFAOYSA-M Cyclamate Chemical compound [Na+].[O-]S(=O)(=O)NC1CCCCC1 UDIPTWFVPPPURJ-UHFFFAOYSA-M 0.000 description 1
RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 description 1
208000002064 Dental Plaque Diseases 0.000 description 1
239000005696 Diammonium phosphate Substances 0.000 description 1
235000019739 Dicalciumphosphate Nutrition 0.000 description 1
OJIYIVCMRYCWSE-UHFFFAOYSA-M Domiphen bromide Chemical compound [Br-].CCCCCCCCCCCC[N+](C)(C)CCOC1=CC=CC=C1 OJIYIVCMRYCWSE-UHFFFAOYSA-M 0.000 description 1
102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
229930091371 Fructose Natural products 0.000 description 1
239000005715 Fructose Substances 0.000 description 1
RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
125000000899 L-alpha-glutamyl group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C([H])([H])C([H])([H])C(O[H])=O 0.000 description 1
KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
235000019501 Lemon oil Nutrition 0.000 description 1
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
239000004472 Lysine Substances 0.000 description 1
GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
AFVFQIVMOAPDHO-UHFFFAOYSA-M Methanesulfonate Chemical compound CS([O-])(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-M 0.000 description 1
DAOANAATJZWTSJ-UHFFFAOYSA-N N-Decanoylmorpholine Chemical compound CCCCCCCCCC(=O)N1CCOCC1 DAOANAATJZWTSJ-UHFFFAOYSA-N 0.000 description 1
SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 description 1
229910002651 NO3 Inorganic materials 0.000 description 1
NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
235000019502 Orange oil Nutrition 0.000 description 1
235000011203 Origanum Nutrition 0.000 description 1
240000000783 Origanum majorana Species 0.000 description 1
108091005804 Peptidases Proteins 0.000 description 1
102000035195 Peptidases Human genes 0.000 description 1
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
101100067993 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) ASC1 gene Proteins 0.000 description 1
101100067991 Schizosaccharomyces pombe (strain 972 / ATCC 24843) rkp1 gene Proteins 0.000 description 1
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
229930006000 Sucrose Natural products 0.000 description 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
208000004509 Tooth Discoloration Diseases 0.000 description 1
206010044032 Tooth discolouration Diseases 0.000 description 1
229920001615 Tragacanth Polymers 0.000 description 1
238000002441 X-ray diffraction Methods 0.000 description 1
TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 description 1
VEUACKUBDLVUAC-UHFFFAOYSA-N [Na].[Ca] Chemical class [Na].[Ca] VEUACKUBDLVUAC-UHFFFAOYSA-N 0.000 description 1
YKTSYUJCYHOUJP-UHFFFAOYSA-N [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] Chemical compound [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] YKTSYUJCYHOUJP-UHFFFAOYSA-N 0.000 description 1
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
230000004913 activation Effects 0.000 description 1
238000007792 addition Methods 0.000 description 1
230000002411 adverse Effects 0.000 description 1
125000002723 alicyclic group Chemical group 0.000 description 1
229910001515 alkali metal fluoride Inorganic materials 0.000 description 1
229910052784 alkaline earth metal Inorganic materials 0.000 description 1
150000001342 alkaline earth metals Chemical class 0.000 description 1
125000003545 alkoxy group Chemical group 0.000 description 1
150000008052 alkyl sulfonates Chemical class 0.000 description 1
XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
229910000323 aluminium silicate Inorganic materials 0.000 description 1
150000001409 amidines Chemical class 0.000 description 1
229910021529 ammonia Inorganic materials 0.000 description 1
150000003868 ammonium compounds Chemical class 0.000 description 1
230000002421 anti-septic effect Effects 0.000 description 1
229940064004 antiseptic throat preparations Drugs 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
230000001580 bacterial effect Effects 0.000 description 1
OYLGJCQECKOTOL-UHFFFAOYSA-L barium fluoride Chemical compound [F-].[F-].[Ba+2] OYLGJCQECKOTOL-UHFFFAOYSA-L 0.000 description 1
229910001632 barium fluoride Inorganic materials 0.000 description 1
SRSXLGNVWSONIS-UHFFFAOYSA-M benzenesulfonate Chemical compound [O-]S(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-M 0.000 description 1
235000010233 benzoic acid Nutrition 0.000 description 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
150000004287 bisbiguanides Chemical class 0.000 description 1
239000007844 bleaching agent Substances 0.000 description 1
210000000988 bone and bone Anatomy 0.000 description 1
239000000872 buffer Substances 0.000 description 1
229910000019 calcium carbonate Inorganic materials 0.000 description 1
239000001110 calcium chloride Substances 0.000 description 1
235000011148 calcium chloride Nutrition 0.000 description 1
229910001628 calcium chloride Inorganic materials 0.000 description 1
WUKWITHWXAAZEY-UHFFFAOYSA-L calcium difluoride Chemical compound [F-].[F-].[Ca+2] WUKWITHWXAAZEY-UHFFFAOYSA-L 0.000 description 1
JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 description 1
229910001634 calcium fluoride Inorganic materials 0.000 description 1
229940043256 calcium pyrophosphate Drugs 0.000 description 1
239000004202 carbamide Substances 0.000 description 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
239000008112 carboxymethyl-cellulose Substances 0.000 description 1
230000015556 catabolic process Effects 0.000 description 1
150000001767 cationic compounds Chemical class 0.000 description 1
150000001768 cations Chemical class 0.000 description 1
230000009920 chelation Effects 0.000 description 1
WDRFFJWBUDTUCA-UHFFFAOYSA-N chlorhexidine acetate Chemical compound CC(O)=O.CC(O)=O.C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 WDRFFJWBUDTUCA-UHFFFAOYSA-N 0.000 description 1
229960001884 chlorhexidine diacetate Drugs 0.000 description 1
125000000068 chlorophenyl group Chemical group 0.000 description 1
ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical class C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 description 1
229960002376 chymotrypsin Drugs 0.000 description 1
239000010630 cinnamon oil Substances 0.000 description 1
238000004140 cleaning Methods 0.000 description 1
239000010634 clove oil Substances 0.000 description 1
239000008119 colloidal silica Substances 0.000 description 1
229940075614 colloidal silicon dioxide Drugs 0.000 description 1
238000010668 complexation reaction Methods 0.000 description 1
239000007859 condensation product Substances 0.000 description 1
BMRUOURRLCCWHB-UHFFFAOYSA-M copper(i) fluoride Chemical compound [Cu]F BMRUOURRLCCWHB-UHFFFAOYSA-M 0.000 description 1
GWFAVIIMQDUCRA-UHFFFAOYSA-L copper(ii) fluoride Chemical compound [F-].[F-].[Cu+2] GWFAVIIMQDUCRA-UHFFFAOYSA-L 0.000 description 1
239000000625 cyclamic acid and its Na and Ca salt Substances 0.000 description 1
230000007423 decrease Effects 0.000 description 1
230000006735 deficit Effects 0.000 description 1
208000002925 dental caries Diseases 0.000 description 1
239000000551 dentifrice Substances 0.000 description 1
MNNHAPBLZZVQHP-UHFFFAOYSA-N diammonium hydrogen phosphate Chemical compound [NH4+].[NH4+].OP([O-])([O-])=O MNNHAPBLZZVQHP-UHFFFAOYSA-N 0.000 description 1
229910000388 diammonium phosphate Inorganic materials 0.000 description 1
235000019838 diammonium phosphate Nutrition 0.000 description 1
235000019821 dicalcium diphosphate Nutrition 0.000 description 1
NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 1
229910000390 dicalcium phosphate Inorganic materials 0.000 description 1
229940038472 dicalcium phosphate Drugs 0.000 description 1
DGTVXEHQMSJRPE-UHFFFAOYSA-M difluorophosphinate Chemical compound [O-]P(F)(F)=O DGTVXEHQMSJRPE-UHFFFAOYSA-M 0.000 description 1
210000002249 digestive system Anatomy 0.000 description 1
239000000539 dimer Substances 0.000 description 1
YWEUIGNSBFLMFL-UHFFFAOYSA-N diphosphonate Chemical compound O=P(=O)OP(=O)=O YWEUIGNSBFLMFL-UHFFFAOYSA-N 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
XJWSAJYUBXQQDR-UHFFFAOYSA-M dodecyltrimethylammonium bromide Chemical compound [Br-].CCCCCCCCCCCC[N+](C)(C)C XJWSAJYUBXQQDR-UHFFFAOYSA-M 0.000 description 1
VICYBMUVWHJEFT-UHFFFAOYSA-N dodecyltrimethylammonium ion Chemical compound CCCCCCCCCCCC[N+](C)(C)C VICYBMUVWHJEFT-UHFFFAOYSA-N 0.000 description 1
239000000975 dye Substances 0.000 description 1
CCIVGXIOQKPBKL-UHFFFAOYSA-M ethanesulfonate Chemical compound CCS([O-])(=O)=O CCIVGXIOQKPBKL-UHFFFAOYSA-M 0.000 description 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
239000010642 eucalyptus oil Substances 0.000 description 1
229940044949 eucalyptus oil Drugs 0.000 description 1
210000002744 extracellular matrix Anatomy 0.000 description 1
238000011049 filling Methods 0.000 description 1
150000004673 fluoride salts Chemical class 0.000 description 1
238000005187 foaming Methods 0.000 description 1
235000013305 food Nutrition 0.000 description 1
210000001035 gastrointestinal tract Anatomy 0.000 description 1
239000003349 gelling agent Substances 0.000 description 1
230000002070 germicidal effect Effects 0.000 description 1
208000024693 gingival disease Diseases 0.000 description 1
208000007565 gingivitis Diseases 0.000 description 1
229940050410 gluconate Drugs 0.000 description 1
230000005484 gravity Effects 0.000 description 1
238000000227 grinding Methods 0.000 description 1
125000005843 halogen group Chemical group 0.000 description 1
229910001385 heavy metal Chemical class 0.000 description 1
239000001257 hydrogen Substances 0.000 description 1
229910052739 hydrogen Inorganic materials 0.000 description 1
125000004435 hydrogen atom Chemical class [H]* 0.000 description 1
239000012535 impurity Substances 0.000 description 1
238000001727 in vivo Methods 0.000 description 1
239000003999 initiator Substances 0.000 description 1
229910001506 inorganic fluoride Inorganic materials 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
LIKBJVNGSGBSGK-UHFFFAOYSA-N iron(3+);oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[Fe+3].[Fe+3] LIKBJVNGSGBSGK-UHFFFAOYSA-N 0.000 description 1
JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
239000008101 lactose Substances 0.000 description 1
239000010501 lemon oil Substances 0.000 description 1
229910000400 magnesium phosphate tribasic Inorganic materials 0.000 description 1
239000001525 mentha piperita l. herb oil Substances 0.000 description 1
239000001683 mentha spicata herb oil Substances 0.000 description 1
HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
229960001047 methyl salicylate Drugs 0.000 description 1
125000001624 naphthyl group Chemical group 0.000 description 1
229920003052 natural elastomer Polymers 0.000 description 1
229920001194 natural rubber Polymers 0.000 description 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
239000002667 nucleating agent Substances 0.000 description 1
229940023486 oral product Drugs 0.000 description 1
239000013588 oral product Substances 0.000 description 1
239000010502 orange oil Substances 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
238000001139 pH measurement Methods 0.000 description 1
235000019477 peppermint oil Nutrition 0.000 description 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
DLYUQMMRRRQYAE-UHFFFAOYSA-N phosphorus pentoxide Inorganic materials O1P(O2)(=O)OP3(=O)OP1(=O)OP2(=O)O3 DLYUQMMRRRQYAE-UHFFFAOYSA-N 0.000 description 1
229940068196 placebo Drugs 0.000 description 1
239000000902 placebo Substances 0.000 description 1
229920001983 poloxamer Polymers 0.000 description 1
229920001296 polysiloxane Polymers 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
239000011591 potassium Substances 0.000 description 1
239000011698 potassium fluoride Substances 0.000 description 1
235000003270 potassium fluoride Nutrition 0.000 description 1
OQZCJRJRGMMSGK-UHFFFAOYSA-M potassium metaphosphate Chemical compound [K+].[O-]P(=O)=O OQZCJRJRGMMSGK-UHFFFAOYSA-M 0.000 description 1
229940099402 potassium metaphosphate Drugs 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
230000001376 precipitating effect Effects 0.000 description 1
238000001556 precipitation Methods 0.000 description 1
239000002243 precursor Substances 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
230000003449 preventive effect Effects 0.000 description 1
239000000047 product Substances 0.000 description 1
229940070891 pyridium Drugs 0.000 description 1
125000001453 quaternary ammonium group Chemical group 0.000 description 1
239000010670 sage oil Substances 0.000 description 1
239000010672 sassafras oil Substances 0.000 description 1
239000000741 silica gel Substances 0.000 description 1
229910002027 silica gel Inorganic materials 0.000 description 1
239000002002 slurry Substances 0.000 description 1
239000000344 soap Substances 0.000 description 1
WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
235000010234 sodium benzoate Nutrition 0.000 description 1
239000004299 sodium benzoate Substances 0.000 description 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
229960001462 sodium cyclamate Drugs 0.000 description 1
QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 description 1
239000011775 sodium fluoride Substances 0.000 description 1
235000013024 sodium fluoride Nutrition 0.000 description 1
235000019333 sodium laurylsulphate Nutrition 0.000 description 1
229960004711 sodium monofluorophosphate Drugs 0.000 description 1
UGTZMIPZNRIWHX-UHFFFAOYSA-K sodium trimetaphosphate Chemical compound [Na+].[Na+].[Na+].[O-]P1(=O)OP([O-])(=O)OP([O-])(=O)O1 UGTZMIPZNRIWHX-UHFFFAOYSA-K 0.000 description 1
239000002195 soluble material Substances 0.000 description 1
229960002920 sorbitol Drugs 0.000 description 1
ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 description 1
229960002799 stannous fluoride Drugs 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
SFVFIFLLYFPGHH-UHFFFAOYSA-M stearalkonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 SFVFIFLLYFPGHH-UHFFFAOYSA-M 0.000 description 1
238000003756 stirring Methods 0.000 description 1
210000002784 stomach Anatomy 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
229920003051 synthetic elastomer Polymers 0.000 description 1
239000005061 synthetic rubber Substances 0.000 description 1
239000003826 tablet Substances 0.000 description 1
150000003568 thioethers Chemical class 0.000 description 1
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
230000036367 tooth discoloration Effects 0.000 description 1
230000036344 tooth staining Effects 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
229940078499 tricalcium phosphate Drugs 0.000 description 1
229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
235000019731 tricalcium phosphate Nutrition 0.000 description 1
125000005209 triethanolammonium group Chemical group 0.000 description 1
238000005406 washing Methods 0.000 description 1
238000009736 wetting Methods 0.000 description 1
239000009637 wintergreen oil Substances 0.000 description 1
239000000811 xylitol Substances 0.000 description 1
235000010447 xylitol Nutrition 0.000 description 1
HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
229960002675 xylitol Drugs 0.000 description 1
GFQYVLUOOAAOGM-UHFFFAOYSA-N zirconium(iv) silicate Chemical compound [Zr+4].[O-][Si]([O-])([O-])[O-] GFQYVLUOOAAOGM-UHFFFAOYSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
- A61K8/416—Quaternary ammonium compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/43—Guanidines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/88—Polyamides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Birds (AREA)
Epidemiology (AREA)
Oral & Maxillofacial Surgery (AREA)
Cosmetics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

CH8360/81A 1980-12-31 1981-12-30 Mittel zur foerderung der mundhygiene. CH651204A5 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US06/221,664 US4339430A (en)	1980-12-31	1980-12-31	Antibacterial oral composition
US06/221,665 US4339431A (en)	1980-12-31	1980-12-31	Anticalculus oral composition

Publications (1)

Publication Number	Publication Date
CH651204A5 true CH651204A5 (de)	1985-09-13

Family

ID=26916011

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CH8360/81A CH651204A5 (de)	1980-12-31	1981-12-30	Mittel zur foerderung der mundhygiene.

Country Status (18)

Country	Link
KR (1)	KR880001750B1 (pt)
AR (1)	AR228295A1 (pt)
AT (1)	AT377696B (pt)
AU (1)	AU555654B2 (pt)
CA (1)	CA1175358A (pt)
CH (1)	CH651204A5 (pt)
DE (1)	DE3151217A1 (pt)
DK (1)	DK575881A (pt)
ES (1)	ES8302033A1 (pt)
FR (1)	FR2497097B1 (pt)
GB (1)	GB2092000B (pt)
GR (1)	GR76968B (pt)
NL (1)	NL8105896A (pt)
NO (1)	NO155527C (pt)
NZ (1)	NZ199305A (pt)
PH (1)	PH18856A (pt)
PT (1)	PT74225B (pt)
SE (1)	SE448818B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5000943A (en) *	1989-05-30	1991-03-19	Nabisco Brands, Inc.	Canine biscuits containing an inorganic pyrophosphate
US5015485A (en) *	1989-05-30	1991-05-14	Nabisco Brands, Inc.	Dog biscuits having a coating containing an inorganic pyrophosphate
US5000973A (en) *	1989-05-30	1991-03-19	Nabisco Brands, Inc.	Nutritionally-balanced canine biscuits containing an inorganic pyrophosphate
US5114704A (en) *	1989-05-30	1992-05-19	Nabisco Brands, Inc.	Raw hide having a coating containing an inorganic pyrophosphate
US5000940A (en) *	1989-05-30	1991-03-19	Nabisco Brands, Inc.	Devices, compositions and the like having or containing an inorganic pyrophosphate
US5094870A (en) *	1989-05-30	1992-03-10	Nabisco Brands, Inc.	Canine biscuits containing an inorganic pyrophosphate
US5011679A (en) *	1989-05-30	1991-04-30	Nabisco Brands, Inc.	Raw hide having a coating containing an inorganic pyrophosphate
US5047231A (en) *	1989-05-30	1991-09-10	Nabisco Brands, Inc.	Raw hide containing an inorganic pyrophosphate
KR100785232B1 (ko)	2006-06-15	2007-12-11	남두석	치과용 항균 석고 조성물 및 그 제조방법

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DE2015510A1 (de) *	1970-04-01	1971-10-21	ESPE Fabrik pharmazeutischer Präparate GmbH, 8031 Seefeld	Spül- und Reinigungsmittel für Schleimhäute
US3939261A (en) *	1974-08-30	1976-02-17	Colgate-Palmolive Company	Flavored dentifrice
ZA773318B (en) *	1976-06-18	1978-04-26	I Kleinberg	Means and method for improving natural defenses against caries
US4110429A (en) *	1976-12-30	1978-08-29	Colgate-Palmolive Company	Antibacterial oral composition
US4225579A (en) *	1979-02-27	1980-09-30	Israel Kleinberg	Means and method for improving defenses against caries

1981
- 1981-12-17 NZ NZ199305A patent/NZ199305A/en unknown
- 1981-12-18 SE SE8107611A patent/SE448818B/sv not_active IP Right Cessation
- 1981-12-21 GR GR66850A patent/GR76968B/el unknown
- 1981-12-23 DE DE19813151217 patent/DE3151217A1/de not_active Withdrawn
- 1981-12-23 DK DK575881A patent/DK575881A/da not_active Application Discontinuation
- 1981-12-24 AU AU78867/81A patent/AU555654B2/en not_active Ceased
- 1981-12-29 FR FR8124377A patent/FR2497097B1/fr not_active Expired
- 1981-12-29 PH PH26695A patent/PH18856A/en unknown
- 1981-12-29 PT PT74225A patent/PT74225B/pt not_active IP Right Cessation
- 1981-12-29 KR KR1019810005204A patent/KR880001750B1/ko active
- 1981-12-29 NL NL8105896A patent/NL8105896A/nl not_active Application Discontinuation
- 1981-12-30 CH CH8360/81A patent/CH651204A5/de not_active IP Right Cessation
- 1981-12-30 AR AR288015A patent/AR228295A1/es active
- 1981-12-30 NO NO814477A patent/NO155527C/no unknown
- 1981-12-30 AT AT0563081A patent/AT377696B/de not_active IP Right Cessation
- 1981-12-30 ES ES508439A patent/ES8302033A1/es not_active Expired
- 1981-12-30 CA CA000393421A patent/CA1175358A/en not_active Expired
- 1981-12-30 GB GB8139057A patent/GB2092000B/en not_active Expired

Also Published As

Publication number	Publication date
AU7886781A (en)	1982-07-08
AT377696B (de)	1985-04-25
NO814477L (no)	1982-07-01
CA1175358A (en)	1984-10-02
NO155527C (no)	1987-04-15
SE8107611L (sv)	1982-07-01
GB2092000A (en)	1982-08-11
KR880001750B1 (ko)	1988-09-12
FR2497097A1 (fr)	1982-07-02
PT74225B (en)	1983-05-30
PT74225A (en)	1982-01-01
GR76968B (pt)	1984-09-04
SE448818B (sv)	1987-03-23
GB2092000B (en)	1984-06-27
FR2497097B1 (fr)	1986-05-02
ES508439A0 (es)	1982-12-16
ATA563081A (de)	1984-09-15
ES8302033A1 (es)	1982-12-16
DK575881A (da)	1982-07-01
NZ199305A (en)	1984-07-31
NO155527B (no)	1987-01-05
AR228295A1 (es)	1983-02-15
DE3151217A1 (de)	1982-08-05
KR830007064A (ko)	1983-10-14
AU555654B2 (en)	1986-10-02
PH18856A (en)	1985-10-21
NL8105896A (nl)	1982-07-16

Publication	Publication Date	Title
DE3017417C2 (pt)	1990-09-20
DE2756078C2 (pt)	1987-12-03
DE3102272C2 (pt)	1989-11-09
DE69314493T2 (de)	1998-04-23	Präparate zur buccale verwendung
DE2600708A1 (de)	1976-07-22	Praeparate fuer die mund- und zahnpflege
DE3151910C2 (pt)	1993-09-09
DE3044448C2 (pt)	1991-01-24
DE2600709A1 (de)	1976-07-22	Zahnpasta
CH649214A5 (de)	1985-05-15	Oral anwendbare zusammensetzung fuer die foerderung der mundhygiene.
AT390368B (de)	1990-04-25	Stabiles zahnpflegemittel zur verhinderung von zahnbelag
DE3852599T2 (de)	1995-08-17	Orale Zusammensetzungen.
CH645535A5 (de)	1984-10-15	Keine flecken bildendes, gegen zahnfleischentzuendungen wirkendes mundpflegemittel.
CH673392A5 (pt)	1990-03-15
DE3874071T2 (de)	1993-01-14	Zahnsteinverhindernde zusammensetzung.
US4339430A (en)	1982-07-13	Antibacterial oral composition
US4118476A (en)	1978-10-03	Antibacterial oral composition
DE2736155C2 (pt)	1989-04-06
CH651204A5 (de)	1985-09-13	Mittel zur foerderung der mundhygiene.
DE2755847C2 (pt)	1990-04-26
CH661440A5 (de)	1987-07-31	Mittel zur oral-dentalen anwendung gegen plaque und gingivitis.
AT390188B (de)	1990-03-26	Verfahren zur herstellung eines gegen zahnsteinbildung wirksamen mundpflegemittels
DE2842182A1 (de)	1980-02-14	Mundpflegemittel
DE10238537A1 (de)	2003-06-26	Zusammensetzung
DE2722187A1 (de)	1978-11-23	Antibakterielles mundpflegemittel
DE3239976A1 (de)	1983-05-11	Gegen zahnstein wirkendes mundpflegemittel

Legal Events

Date	Code	Title	Description
1988-08-31	PL	Patent ceased
2024-10-31	PL	Patent ceased