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CH632509A5 - Process for preparing N-acyl derivatives and phosphorus-containing N-acyl derivatives of the antibiotic thienamycin - Google Patents

Process for preparing N-acyl derivatives and phosphorus-containing N-acyl derivatives of the antibiotic thienamycin Download PDF

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Publication number
CH632509A5
CH632509A5 CH1462276A CH1462276A CH632509A5 CH 632509 A5 CH632509 A5 CH 632509A5 CH 1462276 A CH1462276 A CH 1462276A CH 1462276 A CH1462276 A CH 1462276A CH 632509 A5 CH632509 A5 CH 632509A5
Authority
CH
Switzerland
Prior art keywords
methyl
amino
carbon atoms
hydrogen
solution
Prior art date
Application number
CH1462276A
Other languages
German (de)
English (en)
Inventor
Louis Barash
Burton Grant Christensen
John Hannah
William Joseph Leanza
David Houng-Min Shih
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of CH632509A5 publication Critical patent/CH632509A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CH1462276A 1975-11-21 1976-11-19 Process for preparing N-acyl derivatives and phosphorus-containing N-acyl derivatives of the antibiotic thienamycin CH632509A5 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US63429175A 1975-11-21 1975-11-21

Publications (1)

Publication Number Publication Date
CH632509A5 true CH632509A5 (en) 1982-10-15

Family

ID=24543192

Family Applications (1)

Application Number Title Priority Date Filing Date
CH1462276A CH632509A5 (en) 1975-11-21 1976-11-19 Process for preparing N-acyl derivatives and phosphorus-containing N-acyl derivatives of the antibiotic thienamycin

Country Status (8)

Country Link
JP (1) JPS5277083A (fr)
CH (1) CH632509A5 (fr)
DE (1) DE2652675A1 (fr)
DK (1) DK523276A (fr)
FR (1) FR2332016A1 (fr)
GB (1) GB1570986A (fr)
NL (1) NL189298C (fr)
SE (1) SE427840B (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2966187D1 (en) * 1978-08-23 1983-10-27 Beecham Group Plc Beta-lactam antibacterial compounds, their preparation and pharmaceutical compositions containing them
AU6377980A (en) * 1979-10-29 1981-05-07 Beecham Group Limited 1-azabicyclo(3,2,0)hept-2-ene derivatives
EP0044142A1 (fr) * 1980-07-03 1982-01-20 Beecham Group Plc Procédé de préparation d'antibiotiques bêta-lactame
WO2017132321A1 (fr) * 2016-01-29 2017-08-03 The Johns Hopkins University Nouveaux inhibiteurs de la croissance bactérienne

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1004670A (en) * 1963-04-23 1965-09-15 Beecham Res Lab Penicillins
GB1348984A (en) * 1970-06-16 1974-03-27 Merck & Co Inc Antibiotics and processes for their production

Also Published As

Publication number Publication date
JPS5277083A (en) 1977-06-29
SE427840B (sv) 1983-05-09
GB1570986A (en) 1980-07-09
NL7612940A (nl) 1977-05-24
FR2332016B1 (fr) 1978-11-10
NL189298C (nl) 1993-03-01
DE2652675A1 (de) 1977-06-02
DE2652675C2 (fr) 1990-02-01
JPS61346B2 (fr) 1986-01-08
NL189298B (nl) 1992-10-01
SE7612960L (sv) 1977-05-22
DK523276A (da) 1977-05-22
FR2332016A1 (fr) 1977-06-17

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PL Patent ceased