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CH611601A5 - Process for the preparation of new cyclopentane derivatives - Google Patents

Process for the preparation of new cyclopentane derivatives

Info

Publication number
CH611601A5
CH611601A5 CH1412975A CH1412975A CH611601A5 CH 611601 A5 CH611601 A5 CH 611601A5 CH 1412975 A CH1412975 A CH 1412975A CH 1412975 A CH1412975 A CH 1412975A CH 611601 A5 CH611601 A5 CH 611601A5
Authority
CH
Switzerland
Prior art keywords
carbonyl
preparation
ethylene
cyclopentane derivatives
hydroxymethylene
Prior art date
Application number
CH1412975A
Inventor
Barbara Joyce Broughton
Michael Peter Lear Caton
Edward Charles John Coffee
Peter James Warren
Original Assignee
May & Baker Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by May & Baker Ltd filed Critical May & Baker Ltd
Publication of CH611601A5 publication Critical patent/CH611601A5/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4056—Esters of arylalkanephosphonic acids
    • C07F9/4059—Compounds containing the structure (RY)2P(=X)-(CH2)n-C(=O)-(CH2)m-Ar, (X, Y = O, S, Se; n>=1, m>=0)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/377—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
    • C07C51/38—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups by decarboxylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The derivatives of the cyclopentane of formula below are prepared by hydrolysis of a corresponding 5-ketal. In this formula, R<2> = aryl or heterocyclyl, n = 5 to 8, and: either A = alkylene, X = trans vinylene or ethylene, Y = carbonyl or hydroxymethylene and Z = direct bond or O or S atom, or A and Z = direct bonds, and X and Y are respectively ethylene and carbonyl, trans vinylene and carbonyl, or ethylene and hydroxymethylene. These compounds are active in particular against gastric acid secretion and for the cicatrisation of gastric ulcers. <IMAGE>
CH1412975A 1974-11-01 1975-10-31 Process for the preparation of new cyclopentane derivatives CH611601A5 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB47400/74A GB1521688A (en) 1974-11-01 1974-11-01 Cyclopentane derivatives

Publications (1)

Publication Number Publication Date
CH611601A5 true CH611601A5 (en) 1979-06-15

Family

ID=10444827

Family Applications (1)

Application Number Title Priority Date Filing Date
CH1412975A CH611601A5 (en) 1974-11-01 1975-10-31 Process for the preparation of new cyclopentane derivatives

Country Status (14)

Country Link
JP (1) JPS51125255A (en)
AU (1) AU499154B2 (en)
BE (1) BE835168A (en)
CH (1) CH611601A5 (en)
DE (1) DE2548955A1 (en)
DK (1) DK492475A (en)
FI (1) FI753055A (en)
FR (1) FR2342062A1 (en)
GB (1) GB1521688A (en)
HU (1) HU173242B (en)
LU (1) LU73701A1 (en)
NL (1) NL7512816A (en)
SE (1) SE7512205L (en)
ZA (1) ZA756875B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4695647A (en) * 1984-03-22 1987-09-22 Drug Science Foundation Aromatic derivatives of 13-azaprostanoic acid
WO1998058911A2 (en) * 1997-06-23 1998-12-30 Pfizer Inc. Prostaglandin agonists
EP1661580B1 (en) 2003-07-25 2014-01-08 Ono Pharmaceutical Co., Ltd. Remedy for cartilage-related diseases

Also Published As

Publication number Publication date
FR2342062B1 (en) 1979-09-21
GB1521688A (en) 1978-08-16
DK492475A (en) 1976-05-02
SE7512205L (en) 1976-05-03
NL7512816A (en) 1976-05-04
FI753055A (en) 1976-05-02
FR2342062A1 (en) 1977-09-23
DE2548955A1 (en) 1976-05-13
ZA756875B (en) 1977-06-29
AU8625075A (en) 1977-05-26
LU73701A1 (en) 1976-08-13
BE835168A (en) 1976-04-30
JPS51125255A (en) 1976-11-01
AU499154B2 (en) 1979-04-05
HU173242B (en) 1979-03-28

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Legal Events

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PL Patent ceased
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