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CH519502A - Hypoglycaemic p-amino alkylbenzene - sulphonamides - Google Patents

Hypoglycaemic p-amino alkylbenzene - sulphonamides

Info

Publication number
CH519502A
CH519502A CH1340269A CH1340269A CH519502A CH 519502 A CH519502 A CH 519502A CH 1340269 A CH1340269 A CH 1340269A CH 1340269 A CH1340269 A CH 1340269A CH 519502 A CH519502 A CH 519502A
Authority
CH
Switzerland
Prior art keywords
max
hypoglycaemic
alkyl
sulphonamides
alkylbenzene
Prior art date
Application number
CH1340269A
Other languages
German (de)
Inventor
Henri Dr Dietrich
Claude Dr Lehmann
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Priority to CH1340269A priority Critical patent/CH519502A/en
Priority to CH90872A priority patent/CH518946A/en
Priority to CH90972A priority patent/CH518947A/en
Priority to SE12576/69A priority patent/SE365513B/xx
Priority to NO366169A priority patent/NO128913B/no
Priority to NL7012728A priority patent/NL7012728A/xx
Priority to ES383346A priority patent/ES383346A1/en
Priority to ES383348A priority patent/ES383348A1/en
Priority to RO7023570A priority patent/RO61494A/ro
Priority to CA092249A priority patent/CA920600A/en
Priority to BG017095A priority patent/BG17552A3/en
Priority to ES383347A priority patent/ES383347A1/en
Priority to CS271875A priority patent/CS171220B2/cs
Priority to AT802470A priority patent/AT294825B/en
Priority to CS605270A priority patent/CS171218B2/cs
Priority to RO7023470A priority patent/RO62420A/en
Priority to BG017094A priority patent/BG17551A3/en
Priority to CS271770A priority patent/CS171219B2/cs
Priority to PL14296970A priority patent/PL73360B1/pl
Priority to BG015602A priority patent/BG17543A3/en
Priority to RO6437770A priority patent/RO56790A/ro
Publication of CH519502A publication Critical patent/CH519502A/en
Priority to NL8003454A priority patent/NL8003454A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D203/22—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • C07D203/24—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C07D233/46—Nitrogen atoms not forming part of a nitro radical with only hydrogen atoms attached to said nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Hypoglycaemic p-aminoalkylbenzenesulphonamides New compounds of formula (I) where m = 2 or 3; R1 = alkyl (max C12), alkenyl (C3-5), cycloalk(en)yl (max C7) or phenylalkyl (max C9); R2 = H or alkyl (max C2); R3 = H, (chloro)alyl (max C7) alkenyl (max C5), cycloalk(en)yl (max C8) phenyl(alk(en)yl (max C10); the phenyl groups are opt. substd. with 1-3Cl, Br, F, CF3, alkyl (max C4) hydroxyl, alkoxy- or alkylthio (max C2); R4 = H or methyl. (I) have hypoglycaemic activity and may be used against diabetes. In an example p-(2-acetamidoethyl) benzenesulphochlroide is added to aqueous NaOH and ethyleneimine and tert. sodiumbutylcyanamide is added to the product to give 1- p-(2-acetamidoethyl)phenylsulphonyl -2-imino 3-(tert. butyl)imidazolidine.
CH1340269A 1969-09-04 1969-09-04 Hypoglycaemic p-amino alkylbenzene - sulphonamides CH519502A (en)

Priority Applications (22)

Application Number Priority Date Filing Date Title
CH1340269A CH519502A (en) 1969-09-04 1969-09-04 Hypoglycaemic p-amino alkylbenzene - sulphonamides
CH90872A CH518946A (en) 1969-09-04 1969-09-04 Hypoglycaemic p-amino alkylbenzene - sulphonamides
CH90972A CH518947A (en) 1969-09-04 1969-09-04 Hypoglycaemic p-amino alkylbenzene - sulphonamides
SE12576/69A SE365513B (en) 1969-09-04 1969-09-12
NO366169A NO128913B (en) 1969-09-04 1969-09-12
NL7012728A NL7012728A (en) 1969-09-04 1970-08-27
ES383347A ES383347A1 (en) 1969-09-04 1970-09-03 Procedure for the preparation of new derivatives of the p-aminoalquil-bencensulfonamida. (Machine-translation by Google Translate, not legally binding)
RO7023470A RO62420A (en) 1969-09-04 1970-09-03 PROCESS FOR THE PREPARATION OF ACYLAMINOETHYL-BENZENSULFONYL-2-IMINO-IMIDAZOLIDINES
RO7023570A RO61494A (en) 1969-09-04 1970-09-03
CA092249A CA920600A (en) 1969-09-04 1970-09-03 Process for the production of new derivatives of p-aminoalkyl benzenesulphonamide
BG017095A BG17552A3 (en) 1969-09-04 1970-09-03 METHOD FOR OBTAINING NEW DERIVATIVES OF P- AMINOALKYLSULFONAMIDE
ES383346A ES383346A1 (en) 1969-09-04 1970-09-03 Procedure for the preparation of new derivatives of the p-aminoalquil-bencensulfonamida. (Machine-translation by Google Translate, not legally binding)
CS271875A CS171220B2 (en) 1969-09-04 1970-09-03
AT802470A AT294825B (en) 1969-09-04 1970-09-03 Process for the preparation of new derivatives of p-aminoalkyl-benzenesulfonamide and their salts
CS605270A CS171218B2 (en) 1969-09-04 1970-09-03
ES383348A ES383348A1 (en) 1969-09-04 1970-09-03 Procedure for the preparation of new derivatives of p-aminoalquil-bencensulfonamida. (Machine-translation by Google Translate, not legally binding)
BG017094A BG17551A3 (en) 1969-09-04 1970-09-03 METHOD FOR OBTAINING NEW DERIVATIVES OF P- AMINOALKYLBENZENE SULFONAMIDE
CS271770A CS171219B2 (en) 1969-09-04 1970-09-03
PL14296970A PL73360B1 (en) 1969-09-04 1970-09-03
BG015602A BG17543A3 (en) 1969-09-04 1970-09-03 METHOD FOR OBTAINING NEW DERIVATIVES OF P-C- AMINOALKYLBENZENE - SULFONAMIDE
RO6437770A RO56790A (en) 1969-09-04 1970-09-03
NL8003454A NL8003454A (en) 1969-09-04 1980-06-13 PROCESS FOR PREPARING DERIVATIVES OF β-AMINOALKYLBENZENE SULFONAMIDE.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1340269A CH519502A (en) 1969-09-04 1969-09-04 Hypoglycaemic p-amino alkylbenzene - sulphonamides

Publications (1)

Publication Number Publication Date
CH519502A true CH519502A (en) 1972-02-29

Family

ID=4392107

Family Applications (3)

Application Number Title Priority Date Filing Date
CH90972A CH518947A (en) 1969-09-04 1969-09-04 Hypoglycaemic p-amino alkylbenzene - sulphonamides
CH1340269A CH519502A (en) 1969-09-04 1969-09-04 Hypoglycaemic p-amino alkylbenzene - sulphonamides
CH90872A CH518946A (en) 1969-09-04 1969-09-04 Hypoglycaemic p-amino alkylbenzene - sulphonamides

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CH90972A CH518947A (en) 1969-09-04 1969-09-04 Hypoglycaemic p-amino alkylbenzene - sulphonamides

Family Applications After (1)

Application Number Title Priority Date Filing Date
CH90872A CH518946A (en) 1969-09-04 1969-09-04 Hypoglycaemic p-amino alkylbenzene - sulphonamides

Country Status (11)

Country Link
AT (1) AT294825B (en)
BG (3) BG17543A3 (en)
CA (1) CA920600A (en)
CH (3) CH518947A (en)
CS (3) CS171218B2 (en)
ES (3) ES383348A1 (en)
NL (2) NL7012728A (en)
NO (1) NO128913B (en)
PL (1) PL73360B1 (en)
RO (3) RO62420A (en)
SE (1) SE365513B (en)

Also Published As

Publication number Publication date
NL8003454A (en) 1980-10-31
RO61494A (en) 1977-01-15
CA920600A (en) 1973-02-06
CH518947A (en) 1972-02-15
PL73360B1 (en) 1974-08-30
AT294825B (en) 1971-12-10
ES383346A1 (en) 1973-01-01
CH518946A (en) 1972-02-15
BG17543A3 (en) 1973-11-10
NL7012728A (en) 1971-03-08
SE365513B (en) 1974-03-25
NO128913B (en) 1974-01-28
CS171218B2 (en) 1976-10-29
RO62420A (en) 1978-02-15
CS171220B2 (en) 1976-10-29
CS171219B2 (en) 1976-10-29
RO56790A (en) 1974-08-01
ES383347A1 (en) 1973-01-16
ES383348A1 (en) 1973-01-16
BG17551A3 (en) 1973-11-10
BG17552A3 (en) 1973-11-10

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Legal Events

Date Code Title Description
PL Patent ceased