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CH306915A - Process for the preparation of a diammonium compound. - Google Patents

Process for the preparation of a diammonium compound.

Info

Publication number
CH306915A
CH306915A CH306915DA CH306915A CH 306915 A CH306915 A CH 306915A CH 306915D A CH306915D A CH 306915DA CH 306915 A CH306915 A CH 306915A
Authority
CH
Switzerland
Prior art keywords
preparation
diammonium compound
ethoxy
bis
diammonium
Prior art date
Application number
Other languages
German (de)
Inventor
Ag J R Geigy
Original Assignee
Ag J R Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ag J R Geigy filed Critical Ag J R Geigy
Publication of CH306915A publication Critical patent/CH306915A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B45/00—Complex metal compounds of azo dyes
    • C09B45/02—Preparation from dyes containing in o-position a hydroxy group and in o'-position hydroxy, alkoxy, carboxyl, amino or keto groups
    • C09B45/24—Disazo or polyazo compounds
    • C09B45/28—Disazo or polyazo compounds containing copper

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

  

  Verfahren     zur    Herstellung einer     Diammoniumverbindung.       Gegenstand vorliegenden Patentes ist ein  Verfahren zur Herstellung einer     Diammo-          niumverbindung.    Das Verfahren ist dadurch  gekennzeichnet, dass man auf 1     Mol        1,10-Bis-          (ss-piperidino-äthoxy)        -dekan    2     Mol        Brömessig-          säure-ätliyiester    einwirken lässt.  



  Die erhaltene neue Verbindung, das     1,10-          Bis-    [ss-     (carbäthoxymethyl-piperidinium)        -äth-          oxy]-clekan-dibromid,    schmilzt bei 172-173 .  Sie soll als Arzneimittel und als Zwischen  produkt für Arzneimittel Verwendung finden.  <I>Beispiel:</I>  3,.96 Teile     1.,10-Bis(ss-piperidino-äthoxy)-          dekan,    20     Volumteile    Aceton und 4 Teile  Bromessigsäure -     äthylester    werden etwa 14       Munden    unter     Rückfluss    gekocht.

   Das quar-         täre        Salz        wird    nach Erkalten, falls ölig ab  geschieden, zuerst durch Kühlen und Reiben  zur Kristallisation gebracht, abgesaugt,     ge-          wünschtenfalls    aus heissem     Butanon,    unter  Zusatz von     Äthanol    umkristallisiert und im  Vakuum bei 50-60  getrocknet. Es schmilzt  bei 172-173 .



  Process for the preparation of a diammonium compound. The present patent relates to a process for the preparation of a diammonium compound. The process is characterized in that 1 mole of 1,10-bis (ss-piperidino-ethoxy) decane is allowed to act on 2 moles of bromessigic acid-ethyl ester.



  The new compound obtained, the 1,10-bis- [ss- (carbäthoxymethyl-piperidinium) -ethoxy] -clekan-dibromide, melts at 172-173. It should be used as a medicinal product and as an intermediate product for medicinal products. <I> Example: </I> 3, .96 parts of 1., 10-bis (ss-piperidino-ethoxy) - decane, 20 parts by volume of acetone and 4 parts of ethyl bromoacetic acid are refluxed for about 14 mouths.

   After cooling, the quaternary salt, if it has separated out oily, is first brought to crystallization by cooling and rubbing, filtered off with suction, if desired recrystallized from hot butanone with the addition of ethanol and dried in vacuo at 50-60. It melts at 172-173.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung einer Diammo- niumverbindung, dadurch gekennzeichnet, dass man auf 1 Mol 1,10-Bis-(ss-piperidino-äthoxy)- dekan 2 -Hol Bromessigsäure-äthylester ein wirken lässt. Die erhaltene neue Verbindung, das 1,10- Bis- [ss- (carbäthoxymethyl - piperidinium) -äth- oxy]-dekan-dibromid, schmilzt bei 172-173 . PATENT CLAIM: Process for the production of a diammonium compound, characterized in that 1 mole of 1,10-bis- (ss-piperidino-ethoxy) -decane 2 -hol is allowed to act on ethyl bromoacetate. The new compound obtained, the 1,10-bis [ss- (carbäthoxymethyl - piperidinium) ethoxy] decane dibromide, melts at 172-173.
CH306915D 1952-04-22 1952-04-22 Process for the preparation of a diammonium compound. CH306915A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH306915T 1952-04-22
CH305263T 1952-04-22

Publications (1)

Publication Number Publication Date
CH306915A true CH306915A (en) 1955-04-30

Family

ID=25734928

Family Applications (1)

Application Number Title Priority Date Filing Date
CH306915D CH306915A (en) 1952-04-22 1952-04-22 Process for the preparation of a diammonium compound.

Country Status (1)

Country Link
CH (1) CH306915A (en)

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