CH304881A - Process for the preparation of a complex copper salt of isonicotinic acid hydrazide. - Google Patents
Process for the preparation of a complex copper salt of isonicotinic acid hydrazide.Info
- Publication number
- CH304881A CH304881A CH304881DA CH304881A CH 304881 A CH304881 A CH 304881A CH 304881D A CH304881D A CH 304881DA CH 304881 A CH304881 A CH 304881A
- Authority
- CH
- Switzerland
- Prior art keywords
- acid hydrazide
- preparation
- copper salt
- isonicotinic acid
- complex copper
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/86—Hydrazides; Thio or imino analogues thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Description
Verfahren zur Herstellung eines komplexen Kupfersalzes von Isonicotinsäurehydrazid. Gegenstand der vorliegenden Erfindung ist ein Verfahren zur Herstellung eines neuen komplexen Kupfersalzes des Isonicotinsäure- hydrazids, dem mutmasslich die folgende For mel zukommt
EMI0001.0006
Das Verfahren gemäss der vorliegenden Erfindung ist dadurch gekennzeichnet, dass Pyridin-4-carbonsäurehydrazid, vorzugsweise in wässeriger Lösung, mit Cuprisulfat zur Umsetzung gebracht wird.
Die neue Verbindung besitzt wertvolle therapeutische Eigenschaften; sie ist insbeson dere gegen Tuberkulose wirksam und soll des halb als Heilmittel verwendet werden.
Die Umsetzung zwischen den Reaktions komponenten wird zweckmässigerweise so durchgeführt, dass eine wässerige Lösung des Cuprisulfats einer' wässerigen Lösung von Pyridin-4-earbonsäurehydrazid bei Raumtem peratur zugesetzt wird. Es erfolgt dabei au genblicklich Ausfällung eines hell grünblau gefärbten, kristallinen Niederschlages, der aus dem 2 Moleküle Kristallwasser enthaltenden komplexen Salz des Pyridin-4-carbonsäure- hydrazids mit Cuprisulfat besteht.
<I>Beispiel:</I> Einer Lösung von 14,0 Gewichtsteilen P3ridin-4-carbonsäurehydrazid in 50 Volum- teilen Wasser wird bei Raumtemperatur eine Lösung von 22,5 Gewichtsteilen Kupfersulfat und 8,4 Gewichtsteilen Natriumaeetat in 100 Volumteilen Wasser zugesetzt. Es fällt so gleich ein hell grünblau gefärbter Nieder schlag aus, der abfiltriert, mit Wasser, Alko hol und Äther gewaschen und getrocknet wird. Es werden hellblaue Kristalle erhalten. Die Ausbeute ist praktisch gleich dem theoreti schen Wert.
Process for the preparation of a complex copper salt of isonicotinic acid hydrazide. The present invention relates to a process for the preparation of a new complex copper salt of isonicotinic acid hydrazide, which presumably has the following formula
EMI0001.0006
The process according to the present invention is characterized in that pyridine-4-carboxylic acid hydrazide, preferably in aqueous solution, is reacted with cupric sulfate.
The new compound has valuable therapeutic properties; it is particularly effective against tuberculosis and should therefore be used as a remedy.
The reaction between the reaction components is expediently carried out in such a way that an aqueous solution of cupric sulfate is added to an aqueous solution of pyridine-4-carboxylic acid hydrazide at room temperature. A light green-blue colored, crystalline precipitate is immediately precipitated, which consists of the complex salt of pyridine-4-carboxylic acid hydrazide with cupric sulfate containing 2 molecules of water of crystallization.
<I> Example: </I> A solution of 14.0 parts by weight of p3ridine-4-carboxylic acid hydrazide in 50 parts by volume of water is added at room temperature to a solution of 22.5 parts by weight of copper sulfate and 8.4 parts by weight of sodium acetate in 100 parts by volume of water. A light green-blue colored precipitate falls out immediately, which is filtered off, washed with water, alcohol and ether and dried. Light blue crystals are obtained. The yield is practically the same as the theoretical value.
Claims (1)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH304881T | 1952-02-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH304881A true CH304881A (en) | 1955-01-31 |
Family
ID=4492256
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH304881D CH304881A (en) | 1952-02-25 | 1952-02-25 | Process for the preparation of a complex copper salt of isonicotinic acid hydrazide. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH304881A (en) |
-
1952
- 1952-02-25 CH CH304881D patent/CH304881A/en unknown
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