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CH235719A - Process for the preparation of a salt of N1-dimethylacroyl-p-aminobenzenesulfonamide. - Google Patents

Process for the preparation of a salt of N1-dimethylacroyl-p-aminobenzenesulfonamide.

Info

Publication number
CH235719A
CH235719A CH235719DA CH235719A CH 235719 A CH235719 A CH 235719A CH 235719D A CH235719D A CH 235719DA CH 235719 A CH235719 A CH 235719A
Authority
CH
Switzerland
Prior art keywords
dimethylacroyl
salt
aminobenzenesulfonamide
preparation
calcium salt
Prior art date
Application number
Other languages
German (de)
Inventor
Ag J R Geigy
Original Assignee
Ag J R Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ag J R Geigy filed Critical Ag J R Geigy
Publication of CH235719A publication Critical patent/CH235719A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

  

  Verfahren zur Herstellung eines     Salzes    des     Ni-Dimethylaeroyl-p-amino-benzolsulfonamids.       Gegenstand vorliegenden Zusatzpatentes  ist ein Verfahren zur     Herstellung    des Cal  ciumsalzes von     N,        Dimethylacroyl-p-amino-          benzolsulfonamid,    dadurch gekennzeichnet,  dass man letzteres durch Umsetzung mit einer  basisch reagierenden     Calciumverbindung    in  sein     Calciumsalz    überführt. Das     Calcium-          salz    ist ein weisses kristallisiertes Pulver,  welches sich in Wasser -leicht löst und thera  peutische Verwendung finden soll.  



       Beispiel:     28 Teile     Calciumoxyd    werden in 200 Tei  len doppelt destilliertem Wasser eine Stunde  zum Sieden erhitzt und die erhaltene Kalk  milch in eine Suspension von 280 Teilen N,  Dimethylacroyl-p-amino-benzolsulfonamid in  500 Teilen doppelt destilliertem Wasser ein  gerührt.

   Nach     einer    Stunde ist das     N,-Dime-          thylacroyl-p-amino-benzolsulfonamid    bei ge-         wöhnlicher    Temperatur bis auf einen Rest  in Lösung gegangen; dabei wird die Reak  tion     phenolphthaleinneutral,    jedoch     lackmus-          alkalisch.    Nachdem eine weitere Stunde bei  10  gerührt worden ist, wird filtriert     und     die klare Lösung im Vakuum zur Trockne  eingedampft. F.     320 ;        pl,    einer kalt gesättig  ten Lösung- = 7,9.



  Process for the preparation of a salt of Ni-dimethylaeroyl-p-amino-benzenesulfonamide. The subject of the present additional patent is a process for the production of the calcium salt of N, dimethylacroyl-p-aminobenzenesulfonamide, characterized in that the latter is converted into its calcium salt by reaction with a basic calcium compound. The calcium salt is a white crystallized powder that dissolves easily in water and is intended to be used therapeutically.



       Example: 28 parts of calcium oxide are heated to boiling in 200 parts of double-distilled water for one hour and the milk lime obtained is stirred into a suspension of 280 parts of N-dimethylacroyl-p-aminobenzenesulfonamide in 500 parts of double-distilled water.

   After one hour, the N, -dimethyllacroyl-p-aminobenzenesulfonamide has dissolved to a residue at normal temperature; the reaction becomes phenolphthalein-neutral, but litmus alkaline. After stirring for a further hour at 10, it is filtered and the clear solution is evaporated to dryness in vacuo. F. 320; pl, a cold saturated solution- = 7.9.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung des Calcium- salzes von N,-Dimethylacroyl-p-amino-benzol- sulfonamid, dadurch gekennzeichnet, dass man letzteres durch Umsetzung mit einer basisch reagierenden Calciumverbindung in sein Cal ciumsalz überführt. Das Calciumsalz ist ein weisses kristallisiertes Pulver, welches sich in Wasser leicht löst und therapeutische Ver wendung finden soll. PATENT CLAIM: Process for the production of the calcium salt of N, -dimethylacroyl-p-amino-benzenesulfonamide, characterized in that the latter is converted into its calcium salt by reaction with a basic calcium compound. The calcium salt is a white crystallized powder that dissolves easily in water and is intended to be used therapeutically.
CH235719D 1942-04-16 1942-04-16 Process for the preparation of a salt of N1-dimethylacroyl-p-aminobenzenesulfonamide. CH235719A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH231995T 1942-04-16
CH235719T 1942-04-16

Publications (1)

Publication Number Publication Date
CH235719A true CH235719A (en) 1944-12-15

Family

ID=25727661

Family Applications (1)

Application Number Title Priority Date Filing Date
CH235719D CH235719A (en) 1942-04-16 1942-04-16 Process for the preparation of a salt of N1-dimethylacroyl-p-aminobenzenesulfonamide.

Country Status (1)

Country Link
CH (1) CH235719A (en)

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