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CH223032A - Process for the production of a condensation product. - Google Patents

Process for the production of a condensation product.

Info

Publication number
CH223032A
CH223032A CH223032DA CH223032A CH 223032 A CH223032 A CH 223032A CH 223032D A CH223032D A CH 223032DA CH 223032 A CH223032 A CH 223032A
Authority
CH
Switzerland
Prior art keywords
condensation product
production
thio
triamino
infusible
Prior art date
Application number
Other languages
German (de)
Inventor
Aktiengesellsc Farbenindustrie
Original Assignee
Ig Farbenindustrie Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ig Farbenindustrie Ag filed Critical Ig Farbenindustrie Ag
Publication of CH223032A publication Critical patent/CH223032A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

  

  Verfahren zur Herstellung     eines        Kondensationsproduktes.       Gegenstand des vorliegenden Patentes ist  ein     Verfahren    zur Herstellung     eines    Konden  sationsproduktes, das dadurch gekennzeichnet  ist,     da.ss    man     2-Thio-4.5.6-triamino-pyrimidin     mit     Oxalsäure    bei Temperaturen über 200'       kondensiert.     



  Die neue Verbindung     bildet    schwach  gelbe,     unschmelgbare,    in     Wasser    und     orga-          nischen.        Lösungsmitteln    unlösliche Stäbchen.  Sie soll therapeutische Verwendung finden.  <I>Beispiel:</I>  1 g     2-Thio-4.5.6-triamino-pyrimi.dinsulfat     werden mit 1 g     Natriumoxalat    und 5 g     kri-          stallisierter        Oxalsäure    im -Ölbad 20 Minuten  auf 230   erhitzt. Das Umsetzungsgut wird in  10 cm' 2n Natronlauge gelöst und die Lösung  heiss in 60 cm' siedende 2n Essigsäure ge  geben.

   Nach dem     Erkalten    wird der Nieder  schlag abgesaugt und erneut mit 5 g kri  stallisierter     Oxalsäure    10 Minuten auf<B>230'</B>    erhitzt, worauf alle     Ogaloäume        zerstört    ist.  Das     Reaktionsgut    wird     in    150     ems        n/10    Na  tronlauge mit Tierkohle gekocht und     ,siedend     langsam in 60 cm' siedende 2n Salzsäure ein  gegossen.

   Man erhält 500 mg     2-Thio-6-amino-          8.    9 -     @dioxypyrimidinopyrazin    als schwach  gelbe Stäbchen,     unschmelzbar    und     unlöslich     in Wasser und organischen Lösungsmitteln.



  Process for the production of a condensation product. The subject of the present patent is a process for the preparation of a condensation product which is characterized in that 2-thio-4,5,6-triamino-pyrimidine is condensed with oxalic acid at temperatures above 200 '.



  The new compound forms pale yellow, infusible, in water and organic. Solvent-insoluble rods. It should find therapeutic use. <I> Example: </I> 1 g of 2-thio-4,5,6-triamino-pyrimidine sulfate are heated to 230 for 20 minutes with 1 g of sodium oxalate and 5 g of crystallized oxalic acid in an oil bath. The reaction mixture is dissolved in 10 cm 2N sodium hydroxide solution and the solution is hot in 60 cm boiling 2N acetic acid.

   After cooling, the precipitate is sucked off and heated again with 5 g of crystallized oxalic acid for 10 minutes to <B> 230 '</B>, whereupon all ogalo spaces are destroyed. The reaction mixture is boiled in 150 ems n / 10 sodium hydroxide solution with animal charcoal and, slowly boiling, is poured into 60 cm 'of boiling 2N hydrochloric acid.

   500 mg of 2-thio-6-amino-8. 9 - @dioxypyrimidinopyrazine are obtained as pale yellow rods, infusible and insoluble in water and organic solvents.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung eines Konden- eationsproduktes, dadurch gekennzeichnet, .dass man 2-Thio-4.5.6-triamino-pyximidin mit Oxaloäure bei Temperaturen über 200 kondensiert. Die neue Verbindung bildet schwaeh gelbe, in Wasser und organischen Lösungs- mitteln unlösliche, unschmelzbare Stäbchen. PATENT CLAIM: Process for the production of a condensation product, characterized in that 2-thio-4,5,6-triamino-pyximidine is condensed with oxaloic acid at temperatures above 200. The new compound forms pale yellow, infusible rods that are insoluble in water and organic solvents.
CH223032D 1940-02-29 1941-02-19 Process for the production of a condensation product. CH223032A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE223032X 1940-02-29
CH219304T 1941-02-19

Publications (1)

Publication Number Publication Date
CH223032A true CH223032A (en) 1942-08-15

Family

ID=25726258

Family Applications (1)

Application Number Title Priority Date Filing Date
CH223032D CH223032A (en) 1940-02-29 1941-02-19 Process for the production of a condensation product.

Country Status (1)

Country Link
CH (1) CH223032A (en)

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