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CH176155A - Process for the preparation of 2-ethoxy-5-propionyl-aminopyridine. - Google Patents

Process for the preparation of 2-ethoxy-5-propionyl-aminopyridine.

Info

Publication number
CH176155A
CH176155A CH176155DA CH176155A CH 176155 A CH176155 A CH 176155A CH 176155D A CH176155D A CH 176155DA CH 176155 A CH176155 A CH 176155A
Authority
CH
Switzerland
Prior art keywords
aminopyridine
propionyl
preparation
ethoxy
ethogy
Prior art date
Application number
Other languages
German (de)
Inventor
Aktiengesellschaft Chem Heyden
Original Assignee
Heyden Chem Fab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Heyden Chem Fab filed Critical Heyden Chem Fab
Publication of CH176155A publication Critical patent/CH176155A/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Description

  

  Verfahren zur Darstellung von     2-Äthogy-5-propionyl-aminopyridin.       Es wurde gefunden, dass man durch Ein  wirkung von     acylierenden        Mitteln    auf die  Äther des     2-O.xy-5-aminopyridins    zu neuen       Pyridinverbindungen    gelangt.

   Da die Äther  des     2-Ogy-5-aminopyridins    durch Reduktion  der nach dem deutschen Patent Nr. 568549  erhältlichen Nitroverbindungen leicht und in  grosser Reinheit gewonnen werden können,  ist auch die neue Klasse der am     Aminstick-          stoff        acylierten    Äther des     2.Ogy-5-aminopyri-          dins    leicht zugänglich.  



  Gegenstand der vorliegenden Erfindung ist  ein Verfahren zur Herstellung von     2-Äthogy-          5-propionyl-aminopyridin,        welches    dadurch  gekennzeichnet ist, dass man 2     -Ätho:cy-5-          aminopyridin    mit einem     propionylierenden     Mittel behandelt. Als     propionylierendes    Mit  tel kann     Propionsäureanhydrid    oder ein     Pro-          pionsäurehalogenid    verwendet werden. In  jedem Fall erhält man das     2-Äthogy-5-pro-          pionylaminopyridin.     



  Die neue Verbindung soll als     Analgeti-          cum    und Sedativum Verwendung finden.    <I>Beispiel:</I>  100     gar        2-Äthogy-5-aminopyridin    werden  in 500 cm' trockenem Äther gelöst und ent  sprechend den bei der     Acylierung    üblichen  Vorsichtsmassregeln langsam mit 100     gr        Pro-          pionsäureanhydrid    behandelt,

   das heisst unter  langsamer Zugabe und Kochen am     Rüekfluss-          kühler.        Man    erhält zirka     96'/o    der Theorie an       2.Äthoxy-5.propionylaminopyridin    als schwach  rötliche Kristallmasse.  



  Nach dem     Umkristallisieren    aus Essig  ester und     Petroläther    oder aus Wasser bil  det die Substanz farblose     .Kristalle    vom F.       95-960.  



  Process for the preparation of 2-ethogy-5-propionyl-aminopyridine. It has been found that the action of acylating agents on the ethers of 2-O.xy-5-aminopyridine leads to new pyridine compounds.

   Since the ethers of 2-Ogy-5-aminopyridine can be obtained easily and in great purity by reducing the nitro compounds obtainable according to German patent no -aminopyridins easily accessible.



  The present invention relates to a process for the preparation of 2-ethogy-5-propionyl-aminopyridine, which is characterized in that 2-etho: cy-5-aminopyridine is treated with a propionylating agent. Propionic anhydride or a propionic acid halide can be used as the propionylating agent. In each case the 2-ethogy-5-propionylaminopyridine is obtained.



  The new compound will be used as an analgesic and sedative. <I> Example: </I> 100 even 2-ethy-5-aminopyridine are dissolved in 500 cm 'of dry ether and slowly treated with 100 g propionic anhydride in accordance with the usual precautionary measures for acylation,

   that means adding slowly and cooking on the reflux cooler. About 96% of theory of 2.ethoxy-5.propionylaminopyridine is obtained as a slightly reddish crystal mass.



  After recrystallization from ethyl acetate and petroleum ether or from water, the substance forms colorless .Kristalle of F. 95-960.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung von 2-Äthogy- 5-propionyl-amino-pyridin, dadurch gekenn zeichnet, dass man 2-Äthogy-5-aminopyridin mit einem propionylierenden Mittel behan delt. Die erhaltene Substanz bildet farblose Kristalle vom F. 95-96 0. PATENT CLAIM: Process for the preparation of 2-ethogy-5-propionyl-aminopyridine, characterized in that 2-ethogy-5-aminopyridine is treated with a propionylating agent. The substance obtained forms colorless crystals with a melting point of 95-960.
CH176155D 1933-03-08 1934-02-01 Process for the preparation of 2-ethoxy-5-propionyl-aminopyridine. CH176155A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE176155X 1933-03-08

Publications (1)

Publication Number Publication Date
CH176155A true CH176155A (en) 1935-03-31

Family

ID=5696601

Family Applications (1)

Application Number Title Priority Date Filing Date
CH176155D CH176155A (en) 1933-03-08 1934-02-01 Process for the preparation of 2-ethoxy-5-propionyl-aminopyridine.

Country Status (1)

Country Link
CH (1) CH176155A (en)

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