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CA986015A - Arylidene cyclanones and process for their use in inhibiting androgen action - Google Patents

Arylidene cyclanones and process for their use in inhibiting androgen action

Info

Publication number
CA986015A
CA986015A CA150,548A CA150548A CA986015A CA 986015 A CA986015 A CA 986015A CA 150548 A CA150548 A CA 150548A CA 986015 A CA986015 A CA 986015A
Authority
CA
Canada
Prior art keywords
cyclanones
arylidene
androgen action
inhibiting androgen
inhibiting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA150,548A
Other versions
CA150548S (en
Inventor
William B. Scanlon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of CA986015A publication Critical patent/CA986015A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/657—Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings
    • C07C49/683—Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings having unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/687—Unsaturated compounds containing a keto groups being part of a ring containing halogen
    • C07C49/697—Unsaturated compounds containing a keto groups being part of a ring containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C07C49/755—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C07D307/46—Doubly bound oxygen atoms, or two oxygen atoms singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/54—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
CA150,548A 1971-09-20 1972-08-30 Arylidene cyclanones and process for their use in inhibiting androgen action Expired CA986015A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US18212371A 1971-09-20 1971-09-20

Publications (1)

Publication Number Publication Date
CA986015A true CA986015A (en) 1976-03-23

Family

ID=22667147

Family Applications (1)

Application Number Title Priority Date Filing Date
CA150,548A Expired CA986015A (en) 1971-09-20 1972-08-30 Arylidene cyclanones and process for their use in inhibiting androgen action

Country Status (15)

Country Link
JP (1) JPS4836155A (en)
AU (1) AU463813B2 (en)
BE (1) BE788991A (en)
CA (1) CA986015A (en)
DD (1) DD103811A5 (en)
DE (1) DE2245518A1 (en)
ES (1) ES406846A1 (en)
FR (1) FR2154536B1 (en)
GB (1) GB1394717A (en)
IE (1) IE36663B1 (en)
IL (1) IL40220A (en)
NL (1) NL7212741A (en)
PH (1) PH10556A (en)
PL (1) PL85198B1 (en)
ZA (1) ZA725886B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4857029A (en) * 1971-09-22 1973-08-10
JPS493029A (en) * 1972-04-27 1974-01-11
JPS5074038A (en) * 1973-11-07 1975-06-18
FR2399426A1 (en) * 1977-08-04 1979-03-02 Unicler A-BENZYLIDENE-CYCLOALCANONES AND CORRESPONDING ALCOHOLS AND THEIR APPLICATION IN THERAPEUTICS
DE2951101A1 (en) * 1979-12-19 1981-06-25 Merck Patent Gmbh, 6100 Darmstadt METHOD FOR PRODUCING AZIDOBENZAL COMPOUNDS
MA21706A1 (en) * 1988-12-29 1990-07-01 Rhone Poulenc Agrochimie BENZOLIDENE AZOLYLMETHYLCYCLOALCANE AND USE AS A FUNGICIDE.
FR2641277B1 (en) * 1988-12-29 1994-08-26 Rhone Poulenc Agrochimie AZOLYLMETHYLCYCLOPENTANE OR CYCLOPENTENE BENZOLIDENE AND USE AS A FUNGICIDE
FR2649101B1 (en) * 1989-06-30 1994-10-28 Rhone Poulenc Agrochimie AZOLYLMETHYLCYCLOHEXANE BENZILIDENE AND USE AS A FUNGICIDE
JPH10273467A (en) * 1997-01-29 1998-10-13 Snow Brand Milk Prod Co Ltd New tetralone or benzopyranone derivative and its production
US6162810A (en) * 1997-11-17 2000-12-19 The Regents Of The University Of California Inadone and tetralone compounds for inhibiting cell proliferation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1160689A (en) * 1953-04-13 1958-07-24 Anton Von Waldheim Chemisch Ph Method for preparing divanillydene-cyclohexanone
FR64M (en) * 1960-07-22 1961-01-09
FR1867M (en) * 1962-04-12 1963-06-17 Egema New composition intended in particular for the treatment of cholesterolemia.
FR1414456A (en) * 1964-11-19 1965-10-15 Eastman Kodak Co Process for the preparation of 2-alkylbutanones and products obtained by carrying out this process

Also Published As

Publication number Publication date
ES406846A1 (en) 1976-05-01
PL85198B1 (en) 1976-04-30
FR2154536A1 (en) 1973-05-11
FR2154536B1 (en) 1976-07-02
IL40220A0 (en) 1972-10-29
DD103811A5 (en) 1974-02-12
PH10556A (en) 1977-06-08
NL7212741A (en) 1973-03-22
AU463813B2 (en) 1975-08-07
GB1394717A (en) 1975-05-21
BE788991A (en) 1973-03-19
DE2245518A1 (en) 1973-04-26
ZA725886B (en) 1974-04-24
JPS4836155A (en) 1973-05-28
AU4618372A (en) 1974-03-07
IE36663B1 (en) 1977-01-19
IL40220A (en) 1976-07-30
IE36663L (en) 1973-03-20

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