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CA3137584C - Derives de 1,1-dioxyde de 3-amino-4h-benzo[e][1,2,4]thiadiazine en tant qu'inhibiteurs de mrgx2 - Google Patents

Derives de 1,1-dioxyde de 3-amino-4h-benzo[e][1,2,4]thiadiazine en tant qu'inhibiteurs de mrgx2

Info

Publication number
CA3137584C
CA3137584C CA3137584A CA3137584A CA3137584C CA 3137584 C CA3137584 C CA 3137584C CA 3137584 A CA3137584 A CA 3137584A CA 3137584 A CA3137584 A CA 3137584A CA 3137584 C CA3137584 C CA 3137584C
Authority
CA
Canada
Prior art keywords
benzo
dioxide
thiadiazine
chloro
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA3137584A
Other languages
English (en)
Other versions
CA3137584A1 (fr
Inventor
Simone Bigi
Allison L. Chambers
Tony Gibson
Jason PICKENS
Steve Swann
Angie Vassar
Feng Zhou
Mitsunori Kono
Masaki Seto
Zenyu Shiokawa
Original Assignee
Solent Therapeutics LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solent Therapeutics LLC filed Critical Solent Therapeutics LLC
Priority claimed from PCT/US2020/030305 external-priority patent/WO2020223255A1/fr
Publication of CA3137584A1 publication Critical patent/CA3137584A1/fr
Application granted granted Critical
Publication of CA3137584C publication Critical patent/CA3137584C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Abstract

L'invention concerne des composés de formule (1), des tautomères correspondants et des sels pharmaceutiquement acceptables des composés ou tautomères, L, R1, R2, R3, R4 et R5 étant définis dans la description. La présente invention concerne également des matériels et des procédés pour préparer les composés de formule (1), des compositions pharmaceutiques les contenant et leur utilisation pour le traitement de maladies, de troubles ou d'états pathologiques associés au MRGX2.
CA3137584A 2019-04-29 2020-04-28 Derives de 1,1-dioxyde de 3-amino-4h-benzo[e][1,2,4]thiadiazine en tant qu'inhibiteurs de mrgx2 Active CA3137584C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962840344P 2019-04-29 2019-04-29
US62/840,344 2019-04-29
PCT/US2020/030305 WO2020223255A1 (fr) 2019-04-29 2020-04-28 Dérivés de 1,1-dioxyde de 3-amino-4h-benzo[e][1,2,4]thiadiazine en tant qu'inhibiteurs de mrgx2

Publications (2)

Publication Number Publication Date
CA3137584A1 CA3137584A1 (fr) 2020-11-05
CA3137584C true CA3137584C (fr) 2025-11-18

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