CA2807508A1 - Implant sous-conjonctival pour une administration d'un medicament dans le segment posterieur - Google Patents
Implant sous-conjonctival pour une administration d'un medicament dans le segment posterieur Download PDFInfo
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- CA2807508A1 CA2807508A1 CA2807508A CA2807508A CA2807508A1 CA 2807508 A1 CA2807508 A1 CA 2807508A1 CA 2807508 A CA2807508 A CA 2807508A CA 2807508 A CA2807508 A CA 2807508A CA 2807508 A1 CA2807508 A1 CA 2807508A1
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- therapeutic
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Classifications
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- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
- A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts, ocular implants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
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- Vascular Medicine (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
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PCT/US2011/046650 WO2012019047A2 (fr) | 2010-08-05 | 2011-08-04 | Implant sous-conjonctival pour une administration d'un médicament dans le segment postérieur |
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EP (1) | EP2600920A4 (fr) |
AU (1) | AU2011285637B2 (fr) |
CA (1) | CA2807508A1 (fr) |
WO (1) | WO2012019047A2 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2015060812A1 (fr) * | 2013-10-21 | 2015-04-30 | Howard University | Traitement d'une maladie oculaire par des inhibiteurs des transporteurs d'efflux |
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AU2010208046B2 (en) | 2009-01-29 | 2014-10-02 | Forsight Vision4, Inc. | Posterior segment drug delivery |
US8623395B2 (en) | 2010-01-29 | 2014-01-07 | Forsight Vision4, Inc. | Implantable therapeutic device |
EP2600930B1 (fr) | 2010-08-05 | 2021-02-17 | ForSight Vision4, Inc. | Appareil d'injection pour l'administration de médicaments |
PT2600812T (pt) | 2010-08-05 | 2021-11-09 | Forsight Vision4 Inc | Aparelho para tratar um olho |
CA2807537C (fr) | 2010-08-05 | 2018-09-18 | Forsight Vision4, Inc. | Procedes et appareils d'administration combinee de medicament |
WO2012068549A2 (fr) | 2010-11-19 | 2012-05-24 | Forsight Vision4, Inc. | Formulations d'agents thérapeutiques pour des dispositifs implantés |
EP2726016B1 (fr) | 2011-06-28 | 2023-07-19 | ForSight Vision4, Inc. | Un appareil pour collecter un échantillon de fluide à partir d'une chambre réservoir d'un dispositif thérapeutique pour l'oeil |
HRP20210676T1 (hr) | 2011-09-16 | 2021-05-28 | Forsight Vision4, Inc. | Uređaj za izmjenu fluida |
WO2013116061A1 (fr) | 2012-02-03 | 2013-08-08 | Forsight Vision4, Inc. | Procédés et instrument pour l'insertion et le retrait de dispositifs thérapeutiques |
HRP20211572T1 (hr) | 2012-06-01 | 2022-02-04 | Novartis Ag | Štrcaljka |
US10251778B2 (en) | 2012-08-06 | 2019-04-09 | Baylor College Of Medicine | Therapeutics dispensing device and methods of making same |
WO2014152959A1 (fr) | 2013-03-14 | 2014-09-25 | Forsight Vision4, Inc. | Systèmes pour l'administration intra-oculaire entretenue de composés à faible solubilité provenant d'un implant de système de pose d'orifice |
US9597227B2 (en) * | 2013-03-15 | 2017-03-21 | Abbott Medical Optics Inc. | Trans-sclera portal for delivery of therapeutic agents |
CA2907681C (fr) | 2013-03-28 | 2022-11-22 | Forsight Vision4, Inc. | Implant ophtalmique pour administrer des substances therapeutiques |
US20160302965A1 (en) | 2013-12-06 | 2016-10-20 | Forsight Vision4, Inc. | Implantable therapeutic devices |
EP3679908B1 (fr) | 2014-07-15 | 2024-09-04 | ForSight Vision4, Inc. | Dispositif de pose d'implant oculaire |
CA2957548A1 (fr) | 2014-08-08 | 2016-02-11 | Forsight Vision4, Inc. | Formulations stables et solubles d'inhibiteurs de la tyrosine kinase de recepteurs, et procedes de preparation de ces dernieres |
US10500091B2 (en) | 2014-11-10 | 2019-12-10 | Forsight Vision4, Inc. | Expandable drug delivery devices and methods of use |
EP3340982B1 (fr) | 2015-08-26 | 2021-12-15 | Achillion Pharmaceuticals, Inc. | Composés pour le traitement de troubles immunitaires et inflammatoires |
AR106018A1 (es) | 2015-08-26 | 2017-12-06 | Achillion Pharmaceuticals Inc | Compuestos de arilo, heteroarilo y heterocíclicos para el tratamiento de trastornos médicos |
CN108137681B (zh) | 2015-09-23 | 2024-06-18 | 豪夫迈·罗氏有限公司 | 抗-vegf抗体的优化的变体 |
JP6912475B2 (ja) * | 2015-11-20 | 2021-08-04 | フォーサイト・ビジョン フォー・インコーポレーテッドForsight Vision4, Inc. | 持続放出性薬物送達機器用の多孔質構造体 |
KR20180133440A (ko) | 2016-04-05 | 2018-12-14 | 포사이트 비젼4, 인크. | 이식 가능한 안구 약물 전달 장치 |
WO2017197051A1 (fr) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | Dégronimères de c3-glutarimide liés à une amine pour la dégradation de protéines cibles |
RU2018145364A (ru) | 2016-06-27 | 2020-07-28 | Ачиллион Фармасьютикалс, Инк. | Хиназолиновые и индольные соединения для лечения медицинских нарушений |
US10874768B2 (en) * | 2017-01-20 | 2020-12-29 | Covidien Lp | Drug eluting medical device |
IL294069B2 (en) | 2017-03-01 | 2023-11-01 | Achillion Pharmaceuticals Inc | Aryl, heteroaryl and heterocyclic pharmaceutical compounds for the treatment of medical disorders |
PE20191758A1 (es) | 2017-03-22 | 2019-12-12 | Genentech Inc | Composiciones de anticuerpo optimizadas para el tratamiento de trastornos oculares |
EP3713528A1 (fr) | 2017-11-21 | 2020-09-30 | ForSight Vision4, Inc. | Appareil d'échange de fluide pour système d'administration à port extensible et méthodes d'utilisation |
CN111432868A (zh) * | 2017-12-05 | 2020-07-17 | 马奎特紧急护理公司 | 刺穿组件和呼吸导管套件 |
JP2021519337A (ja) | 2018-03-26 | 2021-08-10 | シー4 セラピューティクス, インコーポレイテッド | Ikarosの分解のためのセレブロン結合剤 |
JOP20200275A1 (ar) | 2018-05-10 | 2020-11-02 | Regeneron Pharma | صيغ تحتوي على بروتين اندماج لمستقبلvegf مرتفعة التركيز |
EP3841086B1 (fr) | 2018-08-20 | 2025-04-23 | Achillion Pharmaceuticals, Inc. | Composés pharmaceutiques pour le traitement de troubles médicaux liés au facteur d du complément |
EP3846803A4 (fr) | 2018-09-06 | 2022-08-10 | Achillion Pharmaceuticals, Inc. | Composés macrocycliques pour le traitement de troubles médicaux |
WO2020081723A1 (fr) | 2018-10-16 | 2020-04-23 | Georgia State University Research Foundation, Inc. | Promédicaments de monoxyde de carbone pour le traitement de troubles médicaux |
CN109431678B (zh) * | 2018-12-17 | 2021-05-28 | 中国医学科学院北京协和医院 | 经巩膜药物传输系统 |
US20220347167A1 (en) * | 2019-10-05 | 2022-11-03 | The Schepens Eye Research Institute, Inc. | A new treatment for meibomian gland dysfunction |
EP4107166A4 (fr) | 2020-02-20 | 2024-06-26 | Achillion Pharmaceuticals, Inc. | Composés hétéroaryle pour le traitement de troubles médiés par le facteur d du complément |
EP4114392A4 (fr) | 2020-03-05 | 2024-04-10 | C4 Therapeutics, Inc. | Composés pour la dégradation ciblée de la brd9 |
CA3193163A1 (fr) | 2020-09-04 | 2022-03-10 | F. Hoffmann-La Roche Ag | Anticorps se liant a vegf-a et a ang2 et methodes d'utilisation |
WO2022066774A1 (fr) | 2020-09-23 | 2022-03-31 | Achillion Pharmaceuticals, Inc. | Composés pharmaceutiques pour le traitement de troubles à médiation par complément |
USD1033637S1 (en) | 2022-01-24 | 2024-07-02 | Forsight Vision4, Inc. | Fluid exchange device |
AR129268A1 (es) | 2022-05-11 | 2024-08-07 | Hoffmann La Roche | Anticuerpo que se une a vegf-a e il6 y métodos de uso |
EP4547299A1 (fr) * | 2022-07-01 | 2025-05-07 | Genentech Inc. | Système de réservoir d'administration de médicament implantable et rechargeable avec fritte métallique poreuse pour administration intracérébroventriculaire prolongée et procédés d'utilisation |
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---|---|---|---|---|
US5466233A (en) * | 1994-04-25 | 1995-11-14 | Escalon Ophthalmics, Inc. | Tack for intraocular drug delivery and method for inserting and removing same |
US5725493A (en) * | 1994-12-12 | 1998-03-10 | Avery; Robert Logan | Intravitreal medicine delivery |
US20050244472A1 (en) * | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Intraocular drug delivery systems containing excipients with reduced toxicity and related methods |
US20070212397A1 (en) * | 2005-09-15 | 2007-09-13 | Roth Daniel B | Pharmaceutical delivery device and method for providing ocular treatment |
US20080167600A1 (en) * | 2005-09-26 | 2008-07-10 | Peyman Gholam A | Device for delivery of an agent to the eye and other sites |
US8168584B2 (en) * | 2005-10-08 | 2012-05-01 | Potentia Pharmaceuticals, Inc. | Methods of treating age-related macular degeneration by compstatin and analogs thereof |
CA2723753A1 (fr) * | 2008-05-08 | 2009-11-12 | Replenish Pumps, Llc | Pompes d'administration de medicament et procedes de fabrication |
US20100174272A1 (en) * | 2009-01-02 | 2010-07-08 | Weiner Alan L | In-situ refillable ophthalmic implant |
EP3785683B1 (fr) * | 2009-05-18 | 2023-11-01 | Dose Medical Corporation | Implant oculaire à élution de médicament |
-
2011
- 2011-08-04 AU AU2011285637A patent/AU2011285637B2/en not_active Ceased
- 2011-08-04 CA CA2807508A patent/CA2807508A1/fr not_active Abandoned
- 2011-08-04 EP EP11815345.1A patent/EP2600920A4/fr not_active Withdrawn
- 2011-08-04 US US13/814,470 patent/US20130274692A1/en not_active Abandoned
- 2011-08-04 WO PCT/US2011/046650 patent/WO2012019047A2/fr active Application Filing
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015060812A1 (fr) * | 2013-10-21 | 2015-04-30 | Howard University | Traitement d'une maladie oculaire par des inhibiteurs des transporteurs d'efflux |
Also Published As
Publication number | Publication date |
---|---|
WO2012019047A2 (fr) | 2012-02-09 |
AU2011285637B2 (en) | 2014-10-30 |
EP2600920A2 (fr) | 2013-06-12 |
EP2600920A4 (fr) | 2017-10-04 |
WO2012019047A3 (fr) | 2012-05-10 |
US20130274692A1 (en) | 2013-10-17 |
AU2011285637A1 (en) | 2013-03-07 |
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