CA2645982A1 - Utilisation de l'ave5026 pour reduire la frequence des saignements durant un traitement antithrombotique - Google Patents
Utilisation de l'ave5026 pour reduire la frequence des saignements durant un traitement antithrombotique Download PDFInfo
- Publication number
- CA2645982A1 CA2645982A1 CA2645982A CA2645982A CA2645982A1 CA 2645982 A1 CA2645982 A1 CA 2645982A1 CA 2645982 A CA2645982 A CA 2645982A CA 2645982 A CA2645982 A CA 2645982A CA 2645982 A1 CA2645982 A1 CA 2645982A1
- Authority
- CA
- Canada
- Prior art keywords
- ave5026
- treatment
- patients
- incidence
- bleedings
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 208000032843 Hemorrhage Diseases 0.000 title claims abstract description 55
- 208000034158 bleeding Diseases 0.000 title claims abstract description 53
- 231100000319 bleeding Toxicity 0.000 title claims abstract description 52
- 230000000740 bleeding effect Effects 0.000 title claims abstract description 52
- 238000011282 treatment Methods 0.000 title claims abstract description 35
- 239000003146 anticoagulant agent Substances 0.000 title claims abstract description 23
- 230000002785 anti-thrombosis Effects 0.000 title claims abstract description 20
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims description 32
- 238000001356 surgical procedure Methods 0.000 claims description 23
- 206010014522 Embolism venous Diseases 0.000 claims description 14
- 208000004043 venous thromboembolism Diseases 0.000 claims description 14
- 229960000610 enoxaparin Drugs 0.000 claims description 13
- 238000011321 prophylaxis Methods 0.000 claims description 8
- 238000013150 knee replacement Methods 0.000 claims description 7
- 230000009424 thromboembolic effect Effects 0.000 claims description 6
- 239000008194 pharmaceutical composition Substances 0.000 claims description 5
- 206010051055 Deep vein thrombosis Diseases 0.000 claims description 4
- 206010028980 Neoplasm Diseases 0.000 claims description 4
- 208000010378 Pulmonary Embolism Diseases 0.000 claims description 4
- 206010047249 Venous thrombosis Diseases 0.000 claims description 4
- 201000011510 cancer Diseases 0.000 claims description 4
- 206010020100 Hip fracture Diseases 0.000 claims description 3
- 238000012084 abdominal surgery Methods 0.000 claims description 3
- 230000008901 benefit Effects 0.000 claims description 3
- 238000002512 chemotherapy Methods 0.000 claims description 2
- 238000011540 hip replacement Methods 0.000 claims description 2
- 229920000669 heparin Polymers 0.000 description 22
- 229960002897 heparin Drugs 0.000 description 16
- 238000000034 method Methods 0.000 description 14
- -1 benzyl ester Chemical class 0.000 description 12
- 230000000694 effects Effects 0.000 description 11
- SIYLLGKDQZGJHK-UHFFFAOYSA-N dimethyl-(phenylmethyl)-[2-[2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy]ethyl]ammonium Chemical class C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 SIYLLGKDQZGJHK-UHFFFAOYSA-N 0.000 description 10
- 229940079593 drug Drugs 0.000 description 10
- 239000003814 drug Substances 0.000 description 10
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 231100000673 dose–response relationship Toxicity 0.000 description 6
- 229940127215 low-molecular weight heparin Drugs 0.000 description 6
- 230000002980 postoperative effect Effects 0.000 description 6
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 6
- 159000000000 sodium salts Chemical class 0.000 description 6
- 230000009471 action Effects 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 5
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 4
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 4
- 229960003872 benzethonium Drugs 0.000 description 4
- UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 description 4
- 229960001950 benzethonium chloride Drugs 0.000 description 4
- KCXMKQUNVWSEMD-UHFFFAOYSA-N benzyl chloride Chemical compound ClCC1=CC=CC=C1 KCXMKQUNVWSEMD-UHFFFAOYSA-N 0.000 description 4
- 229940073608 benzyl chloride Drugs 0.000 description 4
- 230000032050 esterification Effects 0.000 description 4
- 238000005886 esterification reaction Methods 0.000 description 4
- 239000003055 low molecular weight heparin Substances 0.000 description 4
- 230000007170 pathology Effects 0.000 description 4
- 238000007127 saponification reaction Methods 0.000 description 4
- 239000001632 sodium acetate Substances 0.000 description 4
- 235000017281 sodium acetate Nutrition 0.000 description 4
- 238000007920 subcutaneous administration Methods 0.000 description 4
- WMFOQBRAJBCJND-UHFFFAOYSA-M Lithium hydroxide Chemical compound [Li+].[OH-] WMFOQBRAJBCJND-UHFFFAOYSA-M 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- 150000008044 alkali metal hydroxides Chemical class 0.000 description 3
- 239000012736 aqueous medium Substances 0.000 description 3
- 239000002585 base Substances 0.000 description 3
- 230000003247 decreasing effect Effects 0.000 description 3
- 150000002148 esters Chemical class 0.000 description 3
- ZFGMDIBRIDKWMY-PASTXAENSA-N heparin Chemical compound CC(O)=N[C@@H]1[C@@H](O)[C@H](O)[C@@H](COS(O)(=O)=O)O[C@@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O[C@H]2[C@@H]([C@@H](OS(O)(=O)=O)[C@@H](O[C@@H]3[C@@H](OC(O)[C@H](OS(O)(=O)=O)[C@H]3O)C(O)=O)O[C@@H]2O)CS(O)(=O)=O)[C@H](O)[C@H]1O ZFGMDIBRIDKWMY-PASTXAENSA-N 0.000 description 3
- 238000000746 purification Methods 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 238000007619 statistical method Methods 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 208000012671 Gastrointestinal haemorrhages Diseases 0.000 description 2
- 206010062237 Renal impairment Diseases 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 230000001476 alcoholic effect Effects 0.000 description 2
- 229940127219 anticoagulant drug Drugs 0.000 description 2
- 229940127218 antiplatelet drug Drugs 0.000 description 2
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000007717 exclusion Effects 0.000 description 2
- GKTNLYAAZKKMTQ-UHFFFAOYSA-N n-[bis(dimethylamino)phosphinimyl]-n-methylmethanamine Chemical compound CN(C)P(=N)(N(C)C)N(C)C GKTNLYAAZKKMTQ-UHFFFAOYSA-N 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 230000000399 orthopedic effect Effects 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 239000012429 reaction media Substances 0.000 description 2
- 230000035484 reaction time Effects 0.000 description 2
- 238000002694 regional anesthesia Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- VSCBATMPTLKTOV-UHFFFAOYSA-N 2-tert-butylimino-n,n-diethyl-1,3-dimethyl-1,3,2$l^{5}-diazaphosphinan-2-amine Chemical compound CCN(CC)P1(=NC(C)(C)C)N(C)CCCN1C VSCBATMPTLKTOV-UHFFFAOYSA-N 0.000 description 1
- GNFTZDOKVXKIBK-UHFFFAOYSA-N 3-(2-methoxyethoxy)benzohydrazide Chemical compound COCCOC1=CC=CC(C(=O)NN)=C1 GNFTZDOKVXKIBK-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical class [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
- FGUUSXIOTUKUDN-IBGZPJMESA-N C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 Chemical compound C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 FGUUSXIOTUKUDN-IBGZPJMESA-N 0.000 description 1
- 238000000953 Cochran–Armitage test for trend Methods 0.000 description 1
- 238000000959 Cochran–Mantel–Haenszel (CMH) test Methods 0.000 description 1
- 206010010356 Congenital anomaly Diseases 0.000 description 1
- 229920000045 Dermatan sulfate Polymers 0.000 description 1
- 206010015769 Extradural haematoma Diseases 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 description 1
- 208000032382 Ischaemic stroke Diseases 0.000 description 1
- 208000012902 Nervous system disease Diseases 0.000 description 1
- 208000025966 Neurological disease Diseases 0.000 description 1
- 206010040047 Sepsis Diseases 0.000 description 1
- 208000032562 Spinal haematoma Diseases 0.000 description 1
- 229960001138 acetylsalicylic acid Drugs 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 210000004100 adrenal gland Anatomy 0.000 description 1
- 230000003024 amidolytic effect Effects 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 230000001858 anti-Xa Effects 0.000 description 1
- 229940127217 antithrombotic drug Drugs 0.000 description 1
- 239000003698 antivitamin K Substances 0.000 description 1
- 239000000010 aprotic solvent Substances 0.000 description 1
- 208000037849 arterial hypertension Diseases 0.000 description 1
- 238000011882 arthroplasty Methods 0.000 description 1
- 230000002146 bilateral effect Effects 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 239000003593 chromogenic compound Substances 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 229940109239 creatinine Drugs 0.000 description 1
- 238000009109 curative therapy Methods 0.000 description 1
- 238000012691 depolymerization reaction Methods 0.000 description 1
- 229940051593 dermatan sulfate Drugs 0.000 description 1
- AVJBPWGFOQAPRH-FWMKGIEWSA-L dermatan sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS([O-])(=O)=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](C([O-])=O)O1 AVJBPWGFOQAPRH-FWMKGIEWSA-L 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 210000001508 eye Anatomy 0.000 description 1
- KANJSNBRCNMZMV-ABRZTLGGSA-N fondaparinux Chemical compound O[C@@H]1[C@@H](NS(O)(=O)=O)[C@@H](OC)O[C@H](COS(O)(=O)=O)[C@H]1O[C@H]1[C@H](OS(O)(=O)=O)[C@@H](O)[C@H](O[C@@H]2[C@@H]([C@@H](OS(O)(=O)=O)[C@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O[C@@H]4[C@@H]([C@@H](O)[C@H](O)[C@@H](COS(O)(=O)=O)O4)NS(O)(=O)=O)[C@H](O3)C(O)=O)O)[C@@H](COS(O)(=O)=O)O2)NS(O)(=O)=O)[C@H](C(O)=O)O1 KANJSNBRCNMZMV-ABRZTLGGSA-N 0.000 description 1
- 229960001318 fondaparinux Drugs 0.000 description 1
- 208000030304 gastrointestinal bleeding Diseases 0.000 description 1
- 208000031169 hemorrhagic disease Diseases 0.000 description 1
- 239000007972 injectable composition Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 238000007917 intracranial administration Methods 0.000 description 1
- 239000000193 iodinated contrast media Substances 0.000 description 1
- 238000007449 liver function test Methods 0.000 description 1
- 238000007477 logistic regression Methods 0.000 description 1
- 229940118179 lovenox Drugs 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 238000012829 orthopaedic surgery Methods 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 210000004738 parenchymal cell Anatomy 0.000 description 1
- 210000003516 pericardium Anatomy 0.000 description 1
- 239000000106 platelet aggregation inhibitor Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000011301 standard therapy Methods 0.000 description 1
- 238000011477 surgical intervention Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 206010043554 thrombocytopenia Diseases 0.000 description 1
- 230000002537 thrombolytic effect Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- 229940019333 vitamin k antagonists Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/727—Heparin; Heparan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2645982A CA2645982A1 (fr) | 2008-12-05 | 2008-12-05 | Utilisation de l'ave5026 pour reduire la frequence des saignements durant un traitement antithrombotique |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2645982A CA2645982A1 (fr) | 2008-12-05 | 2008-12-05 | Utilisation de l'ave5026 pour reduire la frequence des saignements durant un traitement antithrombotique |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2645982A1 true CA2645982A1 (fr) | 2010-06-05 |
Family
ID=42229321
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2645982A Abandoned CA2645982A1 (fr) | 2008-12-05 | 2008-12-05 | Utilisation de l'ave5026 pour reduire la frequence des saignements durant un traitement antithrombotique |
Country Status (1)
Country | Link |
---|---|
CA (1) | CA2645982A1 (fr) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2446891A1 (fr) * | 2010-10-28 | 2012-05-02 | Aventis Pharma S.A. | Semuloparin pour utilisation comme traitement antithrombotique en chirurgie abdominale majeure avec une sécurité améliorée en termes de saignements cliniquement pertinents et saignements majeurs |
WO2012055843A1 (fr) * | 2010-10-28 | 2012-05-03 | Aventis Pharma S.A. | Sémuloparine pour la prévention d'une trombo-embolie veineuse majeure chez un patient subissant une chirurgie abdominale majeure |
US20130101524A1 (en) * | 2010-06-25 | 2013-04-25 | Aventis Pharma S.A. | Semuloparin for the extended prevention of a mortality and/or morbidity event in a patient having undergone hip fracture surgery |
US20130102565A1 (en) * | 2010-06-25 | 2013-04-25 | Aventis Pharma S.A. | Semuloparin for the prevention of a mortality and/or morbidity event in a patient undergoing major orthopedic surgery |
US20130102566A1 (en) * | 2010-06-25 | 2013-04-25 | Aventis Pharma S.A. | Semuloparin for use as an antithrombotic treatment in hip replacement surgery with improved safety in terms of clinically relevant bleedings and major bleedings |
-
2008
- 2008-12-05 CA CA2645982A patent/CA2645982A1/fr not_active Abandoned
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20130101524A1 (en) * | 2010-06-25 | 2013-04-25 | Aventis Pharma S.A. | Semuloparin for the extended prevention of a mortality and/or morbidity event in a patient having undergone hip fracture surgery |
US20130102565A1 (en) * | 2010-06-25 | 2013-04-25 | Aventis Pharma S.A. | Semuloparin for the prevention of a mortality and/or morbidity event in a patient undergoing major orthopedic surgery |
US20130102566A1 (en) * | 2010-06-25 | 2013-04-25 | Aventis Pharma S.A. | Semuloparin for use as an antithrombotic treatment in hip replacement surgery with improved safety in terms of clinically relevant bleedings and major bleedings |
EP2446891A1 (fr) * | 2010-10-28 | 2012-05-02 | Aventis Pharma S.A. | Semuloparin pour utilisation comme traitement antithrombotique en chirurgie abdominale majeure avec une sécurité améliorée en termes de saignements cliniquement pertinents et saignements majeurs |
WO2012055843A1 (fr) * | 2010-10-28 | 2012-05-03 | Aventis Pharma S.A. | Sémuloparine pour la prévention d'une trombo-embolie veineuse majeure chez un patient subissant une chirurgie abdominale majeure |
WO2012055844A1 (fr) * | 2010-10-28 | 2012-05-03 | Aventis Pharma S.A. | Sémluparine destinée à être utilisée en tant que traitement antithrombotique dans une chirurgie abdominale majeure ayant une sécurité améliorée en termes de saignements cliniquement pertinents et de saignements majeurs |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Eriksson et al. | The direct thrombin inhibitor melagatran followed by oral ximelagatran compared with enoxaparin for the prevention of venous thromboembolism after total hip or knee replacement: the EXPRESS study | |
Rajgopal et al. | The effects of heparin and low molecular weight heparins on bone | |
Ciccone et al. | Bemiparin, an effective and safe low molecular weight heparin: a review | |
Cosmi et al. | Old and new heparins | |
CN102114031A (zh) | 使用于炎症性肠疾病治疗和预防的透明质酸混合物 | |
CA2645982A1 (fr) | Utilisation de l'ave5026 pour reduire la frequence des saignements durant un traitement antithrombotique | |
JP5636225B2 (ja) | 炎症性腸疾患(ibd)の治療及び予防に使用するための医薬組成物 | |
US20210308228A1 (en) | Method for reducing the occurrence of thrombosis or thromboembolism | |
US20120322760A1 (en) | Methods of treatment with a low molecular weight heparin composition | |
Pineo et al. | Oral delivery of heparin: SNAC and related formulations | |
US6258798B1 (en) | Method for treatment of unstable coronary artery disease by an early revascularisation together with administration of a low molecular weight heparin | |
Mousa | The low molecular weight heparin, tinzaparin, in thrombosis and beyond | |
Turpie | Pentasaccharide Org31540/SR90107A clinical trials update: lessons for practice | |
AU2008255191A1 (en) | Use of Ave5026 for minimizing the incidence of bleedings during an antithrombotic treatment | |
JPH10218902A (ja) | 低分子化硫酸化多糖、その製造法及び医薬組成物 | |
Hoy et al. | Tinzaparin sodium: a review of its use in the prevention and treatment of deep vein thrombosis and pulmonary embolism, and in the prevention of clotting in the extracorporeal circuit during haemodialysis | |
Del Bono et al. | Update on low molecular weight heparins at the beginning of third millennium. Focus on reviparin. | |
Kishimoto et al. | M118–A rationally engineered low-molecular-weight heparin designed specifically for the treatment of acute coronary syndromes | |
CA2458852A1 (fr) | Compositions antithrombotiques comportant de l'heparine de faible poids molecule et du dermatane sulfate de poids moleculaire | |
US20060286088A1 (en) | Administration of enoxaparin sodium to patients 75 years and older with ST-segment elevation myocardial infarction | |
Turpie | Setting a standard for venous thromboembolism prophylaxis | |
BRPI0806039A2 (pt) | uso de ave5026 para minimizar a incidência de sangramentos durante um tratamento antitrombótico | |
Pineo et al. | Dalteparin: Pharmacological Properties AND Clinical | |
Jones et al. | Is there a role for pentosan polysulfate in the prevention of calcium oxalate stones? | |
Bates et al. | The new heparins |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Dead |
Effective date: 20131205 |