CA2641940C - Spectrometrie de masse a multiples guides ioniques rf segmentes en plusieurs zones de pression - Google Patents
Spectrometrie de masse a multiples guides ioniques rf segmentes en plusieurs zones de pression Download PDFInfo
- Publication number
- CA2641940C CA2641940C CA2641940A CA2641940A CA2641940C CA 2641940 C CA2641940 C CA 2641940C CA 2641940 A CA2641940 A CA 2641940A CA 2641940 A CA2641940 A CA 2641940A CA 2641940 C CA2641940 C CA 2641940C
- Authority
- CA
- Canada
- Prior art keywords
- ion guide
- ion
- ions
- mass
- multipole ion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- 230000005405 multipole Effects 0.000 claims abstract description 243
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- MDMGHDFNKNZPAU-UHFFFAOYSA-N roserpine Natural products C1C2CN3CCC(C4=CC=C(OC)C=C4N4)=C4C3CC2C(OC(C)=O)C(OC)C1OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 MDMGHDFNKNZPAU-UHFFFAOYSA-N 0.000 description 2
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- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/06—Electron- or ion-optical arrangements
- H01J49/062—Ion guides
- H01J49/063—Multipole ion guides, e.g. quadrupoles, hexapoles
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
- H01J49/34—Dynamic spectrometers
- H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
- H01J49/4205—Device types
- H01J49/422—Two-dimensional RF ion traps
- H01J49/4225—Multipole linear ion traps, e.g. quadrupoles, hexapoles
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Electron Tubes For Measurement (AREA)
Abstract
La présente invention concerne un spectromètre de masse présentant des guides ioniques multipolaires individuels configurés pour former un ensemble aligné le long d'un axe commun. Quatre guides ioniques quadripolaires indépendants (23, 24, 25, 26) et trois segments de guides ioniques quadripolaires plus petits (39, 40, 41) constituant un ensemble linéaire (22) sont positionnés le long d'un axe commun (27) et sont configurés pour former un analyseur de masse à temps de vol, quadripolaire, à sources multiples d'ionisation de pression atmosphérique et à étage de pompage à vide.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38510002P | 2002-05-31 | 2002-05-31 | |
| US60/385,100 | 2002-05-31 | ||
| CA002487136A CA2487136C (fr) | 2002-05-31 | 2003-05-30 | Spectrometrie de masse a multiples guides ioniques rf segmentes en plusieurs zones de pression |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002487136A Division CA2487136C (fr) | 2002-05-31 | 2003-05-30 | Spectrometrie de masse a multiples guides ioniques rf segmentes en plusieurs zones de pression |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2641940A1 CA2641940A1 (fr) | 2003-12-11 |
| CA2641940C true CA2641940C (fr) | 2011-11-15 |
Family
ID=29712134
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2641940A Expired - Lifetime CA2641940C (fr) | 2002-05-31 | 2003-05-30 | Spectrometrie de masse a multiples guides ioniques rf segmentes en plusieurs zones de pression |
| CA002487136A Expired - Lifetime CA2487136C (fr) | 2002-05-31 | 2003-05-30 | Spectrometrie de masse a multiples guides ioniques rf segmentes en plusieurs zones de pression |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002487136A Expired - Lifetime CA2487136C (fr) | 2002-05-31 | 2003-05-30 | Spectrometrie de masse a multiples guides ioniques rf segmentes en plusieurs zones de pression |
Country Status (4)
| Country | Link |
|---|---|
| EP (2) | EP1549914B1 (fr) |
| AU (1) | AU2003249685A1 (fr) |
| CA (2) | CA2641940C (fr) |
| WO (1) | WO2003102508A1 (fr) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10325579B4 (de) * | 2003-06-05 | 2007-10-11 | Bruker Daltonik Gmbh | Ionenfragmentierung durch Elektroneneinfang in linearen Ionenfallen |
| GB0514964D0 (en) * | 2005-07-21 | 2005-08-24 | Ms Horizons Ltd | Mass spectrometer devices & methods of performing mass spectrometry |
| DE102004051785B4 (de) | 2004-10-25 | 2008-04-24 | Bruker Daltonik Gmbh | Proteinprofile mit Luft-MALDI |
| US20060208187A1 (en) * | 2005-03-18 | 2006-09-21 | Alex Mordehai | Apparatus and method for improved sensitivity and duty cycle |
| EP1984934A4 (fr) * | 2006-02-08 | 2015-01-14 | Dh Technologies Dev Pte Ltd | Guide d'ions a frequence radio |
| GB0900973D0 (en) * | 2009-01-21 | 2009-03-04 | Micromass Ltd | Method and apparatus for performing MS^N |
| WO2014197348A2 (fr) * | 2013-06-03 | 2014-12-11 | Perkinelmer Health Sciences, Inc. | Guide d'ions ou filtres présentant une conductance de gaz sélectionnée |
| GB201802917D0 (en) | 2018-02-22 | 2018-04-11 | Micromass Ltd | Charge detection mass spectrometry |
| WO2021207494A1 (fr) | 2020-04-09 | 2021-10-14 | Waters Technologies Corporation | Détecteur d'ions |
| WO2022157719A1 (fr) * | 2021-01-25 | 2022-07-28 | Dh Technologies Development Pte. Ltd. | Régulation de pression dans une chambre à vide d'un spectromètre de masse |
| GB2624012A (en) * | 2022-11-04 | 2024-05-08 | Thermo Fisher Scient Bremen Gmbh | Enhancing mass spectrometer signals |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US694542A (en) | 1901-10-31 | 1902-03-04 | John Peter Gorton | Telegraphy. |
| US2118496A (en) | 1936-03-09 | 1938-05-24 | Corley Mfg Company | Feeding mechanism for sawmills |
| US3410997A (en) | 1964-09-08 | 1968-11-12 | Bell & Howell Co | Multipole mass filter |
| US4542293A (en) | 1983-04-20 | 1985-09-17 | Yale University | Process and apparatus for changing the energy of charged particles contained in a gaseous medium |
| CA1307859C (fr) | 1988-12-12 | 1992-09-22 | Donald James Douglas | Spectrometre de masse a transmission amelioree d'ions |
| US5179278A (en) | 1991-08-23 | 1993-01-12 | Mds Health Group Limited | Multipole inlet system for ion traps |
| US5521380A (en) | 1992-05-29 | 1996-05-28 | Wells; Gregory J. | Frequency modulated selected ion species isolation in a quadrupole ion trap |
| US5689111A (en) | 1995-08-10 | 1997-11-18 | Analytica Of Branford, Inc. | Ion storage time-of-flight mass spectrometer |
| WO1995023018A1 (fr) | 1994-02-28 | 1995-08-31 | Analytica Of Branford, Inc. | Guide d'ions multipolaire pour spectrometrie de masse |
| US6011259A (en) | 1995-08-10 | 2000-01-04 | Analytica Of Branford, Inc. | Multipole ion guide ion trap mass spectrometry with MS/MSN analysis |
| CA2229070C (fr) | 1995-08-11 | 2007-01-30 | Mds Health Group Limited | Spectrometre a champ axial |
| US6177668B1 (en) | 1996-06-06 | 2001-01-23 | Mds Inc. | Axial ejection in a multipole mass spectrometer |
| US6093929A (en) * | 1997-05-16 | 2000-07-25 | Mds Inc. | High pressure MS/MS system |
| GB9717926D0 (en) * | 1997-08-22 | 1997-10-29 | Micromass Ltd | Methods and apparatus for tandem mass spectrometry |
| US6331702B1 (en) * | 1999-01-25 | 2001-12-18 | University Of Manitoba | Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use |
| WO1999062101A1 (fr) | 1998-05-29 | 1999-12-02 | Analytica Of Branford, Inc. | Spectrometrie de masse avec guides d'ions multipolaires |
| US6177688B1 (en) | 1998-11-24 | 2001-01-23 | North Carolina State University | Pendeoepitaxial gallium nitride semiconductor layers on silcon carbide substrates |
| US6194717B1 (en) * | 1999-01-28 | 2001-02-27 | Mds Inc. | Quadrupole mass analyzer and method of operation in RF only mode to reduce background signal |
| US6504148B1 (en) * | 1999-05-27 | 2003-01-07 | Mds Inc. | Quadrupole mass spectrometer with ION traps to enhance sensitivity |
| US6340814B1 (en) | 1999-07-15 | 2002-01-22 | Sciex, A Division Of Mds Inc. | Mass spectrometer with multiple capacitively coupled mass analysis stages |
-
2003
- 2003-05-30 CA CA2641940A patent/CA2641940C/fr not_active Expired - Lifetime
- 2003-05-30 EP EP03756377A patent/EP1549914B1/fr not_active Expired - Lifetime
- 2003-05-30 EP EP11185701A patent/EP2421023A1/fr not_active Withdrawn
- 2003-05-30 CA CA002487136A patent/CA2487136C/fr not_active Expired - Lifetime
- 2003-05-30 AU AU2003249685A patent/AU2003249685A1/en not_active Abandoned
- 2003-05-30 WO PCT/US2003/017437 patent/WO2003102508A1/fr not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2487136A1 (fr) | 2003-12-11 |
| EP1549914A1 (fr) | 2005-07-06 |
| EP1549914B1 (fr) | 2012-12-26 |
| EP2421023A1 (fr) | 2012-02-22 |
| EP1549914A4 (fr) | 2009-03-25 |
| AU2003249685A1 (en) | 2003-12-19 |
| WO2003102508A1 (fr) | 2003-12-11 |
| CA2487136C (fr) | 2008-12-30 |
| CA2641940A1 (fr) | 2003-12-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20230530 |