CA2639461A1 - Echantillons multiples et methode de selection d'un echantllon cible connexe - Google Patents
Echantillons multiples et methode de selection d'un echantllon cible connexe Download PDFInfo
- Publication number
- CA2639461A1 CA2639461A1 CA002639461A CA2639461A CA2639461A1 CA 2639461 A1 CA2639461 A1 CA 2639461A1 CA 002639461 A CA002639461 A CA 002639461A CA 2639461 A CA2639461 A CA 2639461A CA 2639461 A1 CA2639461 A1 CA 2639461A1
- Authority
- CA
- Canada
- Prior art keywords
- sample
- samples
- particles
- particle
- carrier
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 title claims abstract description 16
- 239000002245 particle Substances 0.000 claims abstract description 269
- 230000003287 optical effect Effects 0.000 claims abstract description 96
- 238000005259 measurement Methods 0.000 claims abstract description 47
- 238000001514 detection method Methods 0.000 claims abstract description 32
- 230000035945 sensitivity Effects 0.000 claims abstract description 32
- 238000013459 approach Methods 0.000 claims abstract description 8
- 239000007787 solid Substances 0.000 claims description 13
- 239000012530 fluid Substances 0.000 claims description 12
- 230000005540 biological transmission Effects 0.000 claims description 11
- 239000000203 mixture Substances 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 238000010521 absorption reaction Methods 0.000 claims description 4
- 239000000969 carrier Substances 0.000 claims description 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 51
- 238000012008 microflow imaging Methods 0.000 description 10
- 239000006096 absorbing agent Substances 0.000 description 6
- 239000011248 coating agent Substances 0.000 description 6
- 238000000576 coating method Methods 0.000 description 6
- 239000011521 glass Substances 0.000 description 6
- 239000007788 liquid Substances 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000012538 light obscuration Methods 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 150000003623 transition metal compounds Chemical class 0.000 description 3
- 239000004793 Polystyrene Substances 0.000 description 2
- 239000004809 Teflon Substances 0.000 description 2
- 229920006362 Teflon® Polymers 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 239000005350 fused silica glass Substances 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 239000002086 nanomaterial Substances 0.000 description 2
- 229920002223 polystyrene Polymers 0.000 description 2
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 239000013583 drug formulation Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000004034 viscosity adjusting agent Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/02—Investigating particle size or size distribution
- G01N15/0205—Investigating particle size or size distribution by optical means
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/06—Investigating concentration of particle suspensions
- G01N15/075—Investigating concentration of particle suspensions by optical means
Landscapes
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97193507P | 2007-09-13 | 2007-09-13 | |
| US60/971,935 | 2007-09-13 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2639461A1 true CA2639461A1 (fr) | 2009-03-13 |
| CA2639461C CA2639461C (fr) | 2016-04-05 |
Family
ID=40450994
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2639461A Active CA2639461C (fr) | 2007-09-13 | 2008-09-11 | Echantillons multiples et methode de selection d'un echantllon cible connexe |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2639461C (fr) |
-
2008
- 2008-09-11 CA CA2639461A patent/CA2639461C/fr active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2639461C (fr) | 2016-04-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US6074879A (en) | Synthetic polymer particles for use as standards and calibrators in flow cytometry | |
| Kitchener et al. | A review of the principles of turbidity measurement | |
| Scherer et al. | Issues and challenges of subvisible and submicron particulate analysis in protein solutions | |
| Kratohvil | Light scattering | |
| US7859664B2 (en) | Plurality of samples and method for selecting a target sample therefrom | |
| JP2010527001A (ja) | 低アルカリ度溶液のｐＨを測定するための方法及び装置 | |
| US8976353B2 (en) | Multiwell plate lid for improved optical measurements | |
| US5308767A (en) | Method for control or calibration in a chemical analytical determination | |
| Wang et al. | Solubility at the molecular level: development of a critical aggregation concentration (CAC) assay for estimating compound monomer solubility | |
| US8102528B2 (en) | Particle standard and method of calibrating or validating an optical particle analyzer | |
| BR112014024458B1 (pt) | Método para identificar uma composição líquida | |
| Hubert et al. | A multicompany assessment of submicron particle levels by NTA and RMM in a wide range of late-phase clinical and commercial biotechnology-derived protein products | |
| US20040016686A1 (en) | Absolute measurement centrifuge | |
| CN107677573A (zh) | 一种多峰值颗粒群粒径分布检测方法 | |
| CN102313719B (zh) | 一种定量测量炭黑水分散性的检测方法 | |
| CA2639461C (fr) | Echantillons multiples et methode de selection d'un echantllon cible connexe | |
| Kang et al. | Diffusion of spheres in isotropic and nematic suspensions of rods | |
| JP6679405B2 (ja) | ポリビニルアルコール系樹脂のけん化度分布の測定方法 | |
| Rahn et al. | The strengths of total holographic video microscopy in detecting sub-visible protein particles in biopharmaceuticals: A comparison to Flow Imaging and Resonant Mass Measurement | |
| Zou et al. | Fast and accurate measurement of diffusion coefficient by Taylor’s dispersion analysis | |
| Srinubabu et al. | Development and validation of liquid chromatographic and UV derivative spectrophotometric methods for the determination of famciclovir in pharmaceutical dosage forms | |
| Turcu | Effective phase function for light scattered by disperse systems—the small-angleapproximation | |
| Parveen et al. | A new robust analytical method development, validation, and stress degradation studies for estimating ritonavir by UV-spectroscopy and hplc methods | |
| CA2679394C (fr) | Norme de particule et methodes d'etalonnage ou de validation d'un analyseur de particules optique | |
| Reschiglian et al. | Quantitative analysis by UV-Vis detection in flow-assisted separation techniques for dispersed samples |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20130904 |