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CA2569095A1 - Crystal structure of dipeptidyl peptidase iv (dpp-iv) and uses thereof - Google Patents

Crystal structure of dipeptidyl peptidase iv (dpp-iv) and uses thereof Download PDF

Info

Publication number
CA2569095A1
CA2569095A1 CA002569095A CA2569095A CA2569095A1 CA 2569095 A1 CA2569095 A1 CA 2569095A1 CA 002569095 A CA002569095 A CA 002569095A CA 2569095 A CA2569095 A CA 2569095A CA 2569095 A1 CA2569095 A1 CA 2569095A1
Authority
CA
Canada
Prior art keywords
dpp
computer
amino acid
coordinates
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002569095A
Other languages
English (en)
French (fr)
Inventor
Xiayang Qiu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Products Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2569095A1 publication Critical patent/CA2569095A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CA002569095A 2004-06-03 2005-05-26 Crystal structure of dipeptidyl peptidase iv (dpp-iv) and uses thereof Abandoned CA2569095A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US57687704P 2004-06-03 2004-06-03
US60/576,877 2004-06-03
PCT/IB2005/001630 WO2005119526A1 (en) 2004-06-03 2005-05-26 Crystal structure of dipeptidyl peptidase iv (dpp-iv) and uses thereof

Publications (1)

Publication Number Publication Date
CA2569095A1 true CA2569095A1 (en) 2005-12-15

Family

ID=34969993

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002569095A Abandoned CA2569095A1 (en) 2004-06-03 2005-05-26 Crystal structure of dipeptidyl peptidase iv (dpp-iv) and uses thereof

Country Status (4)

Country Link
EP (1) EP1756740A1 (de)
CA (1) CA2569095A1 (de)
MX (1) MXPA06014083A (de)
WO (1) WO2005119526A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20080251A1 (es) 2006-05-04 2008-04-25 Boehringer Ingelheim Int Usos de inhibidores de dpp iv
BRPI0711558A2 (pt) 2006-05-04 2011-11-08 Boeringer Ingelheim Internat Gmbh polimorfos
EP1852108A1 (de) 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG Zusammensetzungen von DPP-IV-Inhibitoren
US20200155558A1 (en) 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
CA2753884A1 (en) * 2009-02-27 2010-09-02 Trustees Of Tufts College Soft protease inhibitors, and pro-soft forms thereof
US8716482B2 (en) * 2009-09-25 2014-05-06 Merck Sharp & Dohme Corp. Substituted aminopiperidines as dipeptidyl peptidase-IV inhibitors for the treatment of diabetes
EP2366394A1 (de) * 2010-03-17 2011-09-21 IMTM GmbH Charakterisierung und Validierung von Inhibitoren und Liganden der Dipeptidyl-Aminopeptidase IV (DP IV)
US8980929B2 (en) 2010-05-21 2015-03-17 Merck Sharp & Dohme Corp. Substituted seven-membered heterocyclic compounds as dipeptidyl peptidase-iv inhibitors for the treatment of diabetes
EP2600888A2 (de) * 2010-08-03 2013-06-12 Cadila Pharmaceuticals Ltd. Neue verbindungen als dpp-iv-inhibitoren und verfahren zu ihrer herstellung
AR083878A1 (es) 2010-11-15 2013-03-27 Boehringer Ingelheim Int Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento
WO2012170702A1 (en) 2011-06-08 2012-12-13 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto

Also Published As

Publication number Publication date
EP1756740A1 (de) 2007-02-28
WO2005119526A1 (en) 2005-12-15
MXPA06014083A (es) 2007-02-15

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued
FZDE Discontinued

Effective date: 20090526