CA2561784A1 - Implantable delivery device with self adjustable exit port - Google Patents
Implantable delivery device with self adjustable exit port Download PDFInfo
- Publication number
- CA2561784A1 CA2561784A1 CA002561784A CA2561784A CA2561784A1 CA 2561784 A1 CA2561784 A1 CA 2561784A1 CA 002561784 A CA002561784 A CA 002561784A CA 2561784 A CA2561784 A CA 2561784A CA 2561784 A1 CA2561784 A1 CA 2561784A1
- Authority
- CA
- Canada
- Prior art keywords
- slit
- beneficial agent
- chamber
- flow
- delivery device
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000009286 beneficial effect Effects 0.000 abstract 5
- 239000003795 chemical substances by application Substances 0.000 abstract 5
- 239000012530 fluid Substances 0.000 abstract 4
- 238000009792 diffusion process Methods 0.000 abstract 2
- 239000002775 capsule Substances 0.000 abstract 1
- 238000011109 contamination Methods 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 239000002357 osmotic agent Substances 0.000 abstract 1
- 238000005086 pumping Methods 0.000 abstract 1
Landscapes
- Separation Using Semi-Permeable Membranes (AREA)
- External Artificial Organs (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
A delivery device having a first chamber containing an osmotic agent, a membrane forming a wall of the first chamber through which fluid is imbibed by osmosis, a second chamber containing a beneficial agent to be delivered, and a moveable piston separating the two chambers. In fluid communication with the second chamber is an orifice which comprises a slit valve. In the presence of pressure, the beneficial agent pushes through the slit, opening up a channel for delivery of the beneficial agent and creating flow. Because the slit remains closed in the absence of flow (or when the pressure is below the pressure required to open the slit), back diffusion of external fluids is eliminated when the slit is closed, which prevents contamination of the beneficial agent in the second chamber by external fluids. In addition, forward diffusion of the beneficial agent out of the capsule is prevented when the slit is closed. The slit valve opens only to the minimum dimension required to allow the flow generated by the osmostic pumping rate. The slit valve also allows a flow path to open around any obstruction in the slit valve to prevent clogging.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3560797P | 1997-03-24 | 1997-03-24 | |
| US60/035,607 | 1997-03-24 | ||
| CA002284929A CA2284929C (en) | 1997-03-24 | 1998-03-10 | Implantable delivery device with self adjustable exit port |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002284929A Division CA2284929C (en) | 1997-03-24 | 1998-03-10 | Implantable delivery device with self adjustable exit port |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2561784A1 true CA2561784A1 (en) | 1998-10-01 |
| CA2561784C CA2561784C (en) | 2008-01-15 |
Family
ID=37450531
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002561784A Expired - Fee Related CA2561784C (en) | 1997-03-24 | 1998-03-10 | Implantable delivery device with self adjustable exit port |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2561784C (en) |
-
1998
- 1998-03-10 CA CA002561784A patent/CA2561784C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2561784C (en) | 2008-01-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |