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CA2487135A1 - Fragmentation methods for mass spectrometry - Google Patents

Fragmentation methods for mass spectrometry Download PDF

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Publication number
CA2487135A1
CA2487135A1 CA002487135A CA2487135A CA2487135A1 CA 2487135 A1 CA2487135 A1 CA 2487135A1 CA 002487135 A CA002487135 A CA 002487135A CA 2487135 A CA2487135 A CA 2487135A CA 2487135 A1 CA2487135 A1 CA 2487135A1
Authority
CA
Canada
Prior art keywords
mass spectrometry
fragmentation methods
low energy
multipole
ions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002487135A
Other languages
French (fr)
Other versions
CA2487135C (en
Inventor
Craig M. Whitehouse
David G. Welkie
Javahery Gholamreza
Lisa Cousins
Sergey Rakov
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Revvity Health Sciences Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CA2643534A priority Critical patent/CA2643534C/en
Publication of CA2487135A1 publication Critical patent/CA2487135A1/en
Application granted granted Critical
Publication of CA2487135C publication Critical patent/CA2487135C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/06—Electron- or ion-optical arrangements
    • H01J49/062—Ion guides
    • H01J49/063—Multipole ion guides, e.g. quadrupoles, hexapoles
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
    • H01J49/0054—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction by an electron beam, e.g. electron impact dissociation, electron capture dissociation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

Abstract

A method and apparatus for ion fragmentation comprising an RF multipole collision cell (3) where precursor ions are extracted from and transported through RF multipole ion guide (24), said ions being formed by electron capture reaction with low energy electrons generated in low energy electron source (5).
CA002487135A 2002-05-31 2003-05-30 Fragmentation methods for mass spectrometry Expired - Lifetime CA2487135C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2643534A CA2643534C (en) 2002-05-31 2003-05-30 Fragmentation methods for mass spectrometry

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38511302P 2002-05-31 2002-05-31
US60/385,113 2002-05-31
PCT/US2003/017436 WO2003102545A2 (en) 2002-05-31 2003-05-30 Fragmentation methods for mass spectrometry

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA2643534A Division CA2643534C (en) 2002-05-31 2003-05-30 Fragmentation methods for mass spectrometry

Publications (2)

Publication Number Publication Date
CA2487135A1 true CA2487135A1 (en) 2003-12-11
CA2487135C CA2487135C (en) 2009-01-27

Family

ID=29712135

Family Applications (2)

Application Number Title Priority Date Filing Date
CA002487135A Expired - Lifetime CA2487135C (en) 2002-05-31 2003-05-30 Fragmentation methods for mass spectrometry
CA2643534A Expired - Lifetime CA2643534C (en) 2002-05-31 2003-05-30 Fragmentation methods for mass spectrometry

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2643534A Expired - Lifetime CA2643534C (en) 2002-05-31 2003-05-30 Fragmentation methods for mass spectrometry

Country Status (4)

Country Link
EP (1) EP1549923B1 (en)
AU (1) AU2003247472A1 (en)
CA (2) CA2487135C (en)
WO (1) WO2003102545A2 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020115056A1 (en) 2000-12-26 2002-08-22 Goodlett David R. Rapid and quantitative proteome analysis and related methods
GB0305796D0 (en) 2002-07-24 2003-04-16 Micromass Ltd Method of mass spectrometry and a mass spectrometer
DE10325579B4 (en) * 2003-06-05 2007-10-11 Bruker Daltonik Gmbh Ion fragmentation by electron capture in linear ion traps
DE10325582B4 (en) * 2003-06-05 2009-01-15 Bruker Daltonik Gmbh Ion fragmentation by electron capture in high-frequency ion traps with magnetic guidance of the electrons
US6800851B1 (en) * 2003-08-20 2004-10-05 Bruker Daltonik Gmbh Electron-ion fragmentation reactions in multipolar radiofrequency fields
US7026613B2 (en) 2004-01-23 2006-04-11 Thermo Finnigan Llc Confining positive and negative ions with fast oscillating electric potentials
JP4275545B2 (en) * 2004-02-17 2009-06-10 株式会社日立ハイテクノロジーズ Mass spectrometer
GB0404106D0 (en) 2004-02-24 2004-03-31 Shimadzu Res Lab Europe Ltd An ion trap and a method for dissociating ions in an ion trap
EP2835642B1 (en) 2004-03-12 2018-01-17 University Of Virginia Patent Foundation Electron transfer dissociation for biopolymer sequence analysis
GB2414855A (en) * 2004-03-30 2005-12-07 Thermo Finnigan Llc Ion fragmentation by electron capture
DE102004028419B4 (en) * 2004-06-11 2011-06-22 Bruker Daltonik GmbH, 28359 Mass spectrometer and reaction cell for ion-ion reactions
GB2415541B (en) * 2004-06-21 2009-09-23 Thermo Finnigan Llc RF power supply for a mass spectrometer
GB0523811D0 (en) * 2005-11-23 2006-01-04 Micromass Ltd Mass stectrometer
GB0523806D0 (en) * 2005-11-23 2006-01-04 Micromass Ltd Mass spectrometer
GB2432712B (en) 2005-11-23 2007-12-27 Micromass Ltd Mass spectrometer
GB0609253D0 (en) 2006-05-10 2006-06-21 Micromass Ltd Mass spectrometer
WO2023150866A1 (en) * 2022-02-08 2023-08-17 Kimia Analytics Inc. A solid-target collision cell for mass spectrometry

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4731533A (en) * 1986-10-15 1988-03-15 Vestec Corporation Method and apparatus for dissociating ions by electron impact
CA1307859C (en) 1988-12-12 1992-09-22 Donald James Douglas Mass spectrometer and method with improved ion transmission
US4933551A (en) * 1989-06-05 1990-06-12 The United State Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Reversal electron attachment ionizer for detection of trace species
US4988869A (en) * 1989-08-21 1991-01-29 The Regents Of The University Of California Method and apparatus for electron-induced dissociation of molecular species
DE10058706C1 (en) * 2000-11-25 2002-02-28 Bruker Daltonik Gmbh Fragmentation of ions, especially biomolecules comprises capture of low energy electrons in high energy ion trap mass spectrometer with ring electrode to which high frequency voltage and end cap electrodes which are earthed, or vice-versa
CA2441776A1 (en) * 2001-03-22 2002-10-03 Syddansk Universitet Mass spectrometry methods using electron capture by ions

Also Published As

Publication number Publication date
AU2003247472A8 (en) 2003-12-19
WO2003102545A3 (en) 2004-05-06
CA2643534C (en) 2011-08-02
CA2643534A1 (en) 2003-12-11
AU2003247472A1 (en) 2003-12-19
CA2487135C (en) 2009-01-27
WO2003102545A2 (en) 2003-12-11
EP1549923A4 (en) 2009-03-25
EP1549923B1 (en) 2012-10-17
EP1549923A2 (en) 2005-07-06

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Effective date: 20230530