CA2481731A1 - Secreted and transmembrane polypeptides and nucleic acids encoding the same - Google Patents
Secreted and transmembrane polypeptides and nucleic acids encoding the same Download PDFInfo
- Publication number
- CA2481731A1 CA2481731A1 CA002481731A CA2481731A CA2481731A1 CA 2481731 A1 CA2481731 A1 CA 2481731A1 CA 002481731 A CA002481731 A CA 002481731A CA 2481731 A CA2481731 A CA 2481731A CA 2481731 A1 CA2481731 A1 CA 2481731A1
- Authority
- CA
- Canada
- Prior art keywords
- acid sequence
- seq
- amino acid
- nucleic acid
- polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001184 polypeptide Polymers 0.000 title claims abstract 21
- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract 21
- 102000004196 processed proteins & peptides Human genes 0.000 title claims abstract 21
- 150000007523 nucleic acids Chemical class 0.000 title claims abstract 11
- 108020004707 nucleic acids Proteins 0.000 title claims abstract 7
- 102000039446 nucleic acids Human genes 0.000 title claims abstract 7
- 239000013598 vector Substances 0.000 claims abstract 5
- 238000000034 method Methods 0.000 claims abstract 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 10
- 210000004027 cell Anatomy 0.000 claims 9
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 6
- 239000002773 nucleotide Substances 0.000 claims 6
- 125000003729 nucleotide group Chemical group 0.000 claims 6
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 4
- 108091026890 Coding region Proteins 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 210000005253 yeast cell Anatomy 0.000 claims 1
Landscapes
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic add sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention end to methods for producing the polypeptides of the present invention.
Claims (17)
1. Isolated nucleic acid having at least 80% nucleic acid sequence identity to a nucleotide sequence that encodes the amino acid sequence shown in Figure 132 (SEQ
ID NO:132).
ID NO:132).
2.Isolated nucleic acid having at least 80% nucleic acid sequence identity to the nucleotide sequence shown in Figure 131 (SEQ ID NO:131).
3. Isolated nucleic acid having at least 80% nucleic acid sequence identity to the full-length coding sequence of the nucleotide sequence shown in Figure 131 (SEQ ID
NO:131).
NO:131).
4. A vector comprising the nucleic acid of Claim 1.
5. The vector of Claim 4 operably linked to control sequences recognized by a host cell transformed with the vector.
6. A host cell comprising the vector of Claim 4.
7. The host cell of Claim 6, wherein said cell is a CHO cell.
8. The host cell of Claim 6, wherein said cell is an E. coli.
9. The host cell of Claim 6, wherein said cell is a yeast cell.
10. A process for producing a PRO polypeptides comprising culturing the host cell of Claim 7 under conditions suitable fox expression of said PRO polypeptide and recovering said PRO polypeptide from the cell culture.
11. An isolated polypeptide having at least 80% amino acid sequence identity to the amino acid sequence shown in Figure 132 (SEQ ID NO:132).
12. A chimeric molecule comprising a polypeptide according to Claim 11 fused to a heterologous amino acid sequence.
13. The chimeric molecule of Claim 12, wherein said heterologous amino acid sequence is an epitope tag sequence.
14. The chimeric molecule of Claim 12, wherein said heterologous amino acid sequence is a Fc region of an immunoglobulin.
15. A polyclonal antibody which specifically binds to a polypeptide according to Claim 11.
16. Isolated nucleic acid having at least 80 % nucleic acid sequence identity to:
(a) a nucleotide sequence encoding the polypeptide shown in Figure 132 (SEQ ID
NO:132), lacking its associated signal peptide;
(b) a nucleotide sequence encoding an extracellular domain of the polypeptide shown in Figure 132 (SEQ ID NO:132), with its associated signal peptide; or (c) a nucleotide sequence encoding an extracellular domain of the polypeptide shown in Figure 132 (SEQ ID NO:132), lacking its associated signal peptide.
(a) a nucleotide sequence encoding the polypeptide shown in Figure 132 (SEQ ID
NO:132), lacking its associated signal peptide;
(b) a nucleotide sequence encoding an extracellular domain of the polypeptide shown in Figure 132 (SEQ ID NO:132), with its associated signal peptide; or (c) a nucleotide sequence encoding an extracellular domain of the polypeptide shown in Figure 132 (SEQ ID NO:132), lacking its associated signal peptide.
17. An isolated polypeptide having at least 80% amino acid sequence identity to:
(a) an amino acid sequence of the polypeptide shown in Figure 132 (SEQ ID
NO:132), lacking its associated signal peptide;
(b) an amino acid sequence of an extracellular domain of the polypeptide shown in Figure 132 (SEQ ID NO:132), with its associated signal peptide; or (c) an amino acid sequence of an extracellular domain of the polypeptide shown in Figure 132 (SEQ ID NO:132), lacking its associated signal peptide.
(a) an amino acid sequence of the polypeptide shown in Figure 132 (SEQ ID
NO:132), lacking its associated signal peptide;
(b) an amino acid sequence of an extracellular domain of the polypeptide shown in Figure 132 (SEQ ID NO:132), with its associated signal peptide; or (c) an amino acid sequence of an extracellular domain of the polypeptide shown in Figure 132 (SEQ ID NO:132), lacking its associated signal peptide.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| USPCT/US99/20111 | 1999-09-01 | ||
| PCT/US1999/020111 WO2000012708A2 (en) | 1998-09-01 | 1999-09-01 | Further pro polypeptides and sequences thereof |
| CA002380355A CA2380355A1 (en) | 1999-09-01 | 2000-08-24 | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002380355A Division CA2380355A1 (en) | 1999-09-01 | 2000-08-24 | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2481731A1 true CA2481731A1 (en) | 2001-03-08 |
| CA2481731C CA2481731C (en) | 2011-08-09 |
Family
ID=33565692
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2481731A Expired - Lifetime CA2481731C (en) | 1999-09-01 | 2000-08-24 | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| CA002481788A Abandoned CA2481788A1 (en) | 1999-09-01 | 2000-08-24 | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| CA002481685A Abandoned CA2481685A1 (en) | 1999-09-01 | 2000-08-24 | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| CA002481691A Abandoned CA2481691A1 (en) | 1999-09-01 | 2000-08-24 | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| CA002481756A Abandoned CA2481756A1 (en) | 1999-09-01 | 2000-08-24 | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002481788A Abandoned CA2481788A1 (en) | 1999-09-01 | 2000-08-24 | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| CA002481685A Abandoned CA2481685A1 (en) | 1999-09-01 | 2000-08-24 | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| CA002481691A Abandoned CA2481691A1 (en) | 1999-09-01 | 2000-08-24 | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| CA002481756A Abandoned CA2481756A1 (en) | 1999-09-01 | 2000-08-24 | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
Country Status (1)
| Country | Link |
|---|---|
| CA (5) | CA2481731C (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1207387C (en) | 1999-09-29 | 2005-06-22 | 帝人株式会社 | Polypeptides and genes encoding same |
-
2000
- 2000-08-24 CA CA2481731A patent/CA2481731C/en not_active Expired - Lifetime
- 2000-08-24 CA CA002481788A patent/CA2481788A1/en not_active Abandoned
- 2000-08-24 CA CA002481685A patent/CA2481685A1/en not_active Abandoned
- 2000-08-24 CA CA002481691A patent/CA2481691A1/en not_active Abandoned
- 2000-08-24 CA CA002481756A patent/CA2481756A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2481731C (en) | 2011-08-09 |
| CA2481756A1 (en) | 2001-03-08 |
| CA2481691A1 (en) | 2001-03-08 |
| CA2481788A1 (en) | 2001-03-08 |
| CA2481685A1 (en) | 2001-03-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20200824 |