CA2468188A1 - Optical arrangement for assay reading device - Google Patents
Optical arrangement for assay reading device Download PDFInfo
- Publication number
- CA2468188A1 CA2468188A1 CA 2468188 CA2468188A CA2468188A1 CA 2468188 A1 CA2468188 A1 CA 2468188A1 CA 2468188 CA2468188 CA 2468188 CA 2468188 A CA2468188 A CA 2468188A CA 2468188 A1 CA2468188 A1 CA 2468188A1
- Authority
- CA
- Canada
- Prior art keywords
- test strip
- photodetector
- zone
- reading device
- light
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
- G01N21/274—Calibration, base line adjustment, drift correction
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
- G01N21/8483—Investigating reagent band
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
- G01N21/8483—Investigating reagent band
- G01N2021/8488—Investigating reagent band the band presenting reference patches
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
- G01N21/8483—Investigating reagent band
- G01N2021/8494—Measuring or storing parameters of the band
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/06—Illumination; Optics
- G01N2201/061—Sources
- G01N2201/06106—Plural sources used for calibration
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/06—Illumination; Optics
- G01N2201/062—LED's
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Mathematical Physics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Theoretical Computer Science (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plasma & Fusion (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Abstract
Disclosed, in one aspect, is an assay result reading device for reading the result of an assay performed using a test strip, the device comprising: a light source or sources, said light sources emitting light incident upon at least two, spatially separated zones of the test strip; and a photodetector which detects light emanating from each of the two said zones; in a further aspect is disclosed an assay result reading device for reading the result of an assay performed using a test strip, the device comprising: at least one light source incident upon a zone of the test strip; and at least two photodetectors both of which are able to detect some of the light emanating from the zone of the test strip illuminated by the light source.
Claims (14)
1. An assay result reading device for reading the result of an assay performed using a test strip, the device comprising:
at least one light source capable of emitting light incident upon at least two spatially separated zones of the test strip; and a photodetector which detects light emanating from each of the two said zones.
at least one light source capable of emitting light incident upon at least two spatially separated zones of the test strip; and a photodetector which detects light emanating from each of the two said zones.
2. A reading device according to claim 1, further comprising a second photodetector, wherein both photodetectors are so positioned as to detect at least a portion of the light emanating from at least one of the zones of the test strip.
3. A reading device according to claim 2, wherein the two photodetectors are positioned on opposite sizes of the at least one zone and laterally offset from the at least one zone.
4. A reading device according to any one of claims 1, 2 or 3, wherein the at least one light source comprises three light sources.
5. A reading device according to any one of the preceding claims, wherein the at least one light source comprises a light emitting diode (LED).
6. A reading device according to any one of the preceding claims, wherein the photodetector comprises a photodiode.
7. A reading device according to any one of the preceding claims, wherein the photodetector is positioned between the spatially separated zones and is laterally offset from the zones.
8. A reading device according to claim 1, further comprising a second photodetector and wherein:
the test strip has three spatially separated zones;
the at least one light source comprises three LED's;
each LED is aligned with and laterally offset from a corresponding test strip zone;
a first baffle is so sized and positioned as to prevent light emitted by the first LED from illuminating the third zone;
a second baffle is so sized and positioned as to prevent light emitted by the third LED from illuminating the first zone;
the first photodetector is so positioned as to receive light emanating from the first zone and the second zone; and the second photodetector is so positioned as to receive light emanating from the second zone and the third zone.
the test strip has three spatially separated zones;
the at least one light source comprises three LED's;
each LED is aligned with and laterally offset from a corresponding test strip zone;
a first baffle is so sized and positioned as to prevent light emitted by the first LED from illuminating the third zone;
a second baffle is so sized and positioned as to prevent light emitted by the third LED from illuminating the first zone;
the first photodetector is so positioned as to receive light emanating from the first zone and the second zone; and the second photodetector is so positioned as to receive light emanating from the second zone and the third zone.
9. A reading device according to any one of the preceding claims, further comprising a housing enclosing the at least one light source and the photodetector.
10. A reading device according to claim 9, wherein the housing is no larger than about 12 cm long, about 2.5 cm wide, and about 2.2 cm tall.
11. A reading device according to any one of the preceding claims, wherein the at least one light source and the photodetector are disposed within an area no larger than about 1 square centimeter.
12. A reading device according to claim 11, wherein the at least one light source and the photodetector are disposed within an area no larger than about 0.7 square centimeter.
13. A reading device according to any one of the preceding claims, further comprising:
a computation circuit responsive to signals generated by the photodetector representing the presence or absence of a fluid sample in at least one of the zones to:
calculate a flow rate for a fluid flowing along the test strip;
compare the calculated flow rate to upper and lower limits; and reject the assay result if the calculated flow rate is outside the upper and lower limits.
a computation circuit responsive to signals generated by the photodetector representing the presence or absence of a fluid sample in at least one of the zones to:
calculate a flow rate for a fluid flowing along the test strip;
compare the calculated flow rate to upper and lower limits; and reject the assay result if the calculated flow rate is outside the upper and lower limits.
14. A reading device according to any one of the preceding claims, further comprising:
a computation circuit, responsive to an input signal representing the amount of an analyte or the rate of accumulation of an analyte in at least one of the zones of the test strip, to:
compare the input signal to a first threshold;
compare the input signal to a second threshold, the second threshold being less than the first threshold;
generate an output signal if the input signal exceeds the first threshold or the input signal is less than the second threshold, the output signal indicative of a first result if the input signal exceeds the first threshold, or, alternatively, the output signal indicative of a second result if the input signal is less than the second threshold; and terminate the assay if the input signal exceeds the first threshold or the signal is less than the second threshold.
16. An assay result reading device for reading the result of an assay performed using a test strip, the device comprising:
at least one light source capable of emitting light incident upon at least one zone of the test strip; and at least two photodetectors, each of which detects light emanating from the at least one zone of the test strip.
17. A method of determining the result of an assay performed using a test strip, the method comprising:
positioning the test strip in relation to an assay result reader, the reader comprising a housing enclosing at least one light source and a photodetector; and measuring a light level received by the photodetector;
wherein the test strip is so positioned that the at least one light source emits light incident on at least two spatially separated zones of the test strip, and so that light emanating from at least one of the zones is incident on the photodetector.
18. A method according to claim 17, wherein the test strip is positioned at least partly inside the assay result reader.
19. A method according to claim 17 or 18, wherein the assay result reader further comprises a second photodetector, the at least one light source comprises first, second, and third light sources, the test strip has three spatially separated zones, and wherein:
each light source is aligned with and laterally offset from a corresponding test strip zone;
the first photodetector is so positioned as to receive light emanating from the first zone and the second zone; and the second photodetector is so positioned as to receive light emanating from the second zone and the third zone.
20. A method of determining the result of an assay performed using a test strip, the method comprising:
positioning the test strip in relation to an assay result reader, the reader comprising a housing enclosing at least one light source and at least two photodetectors; and measuring a light level received by the photodetector;
wherein the test strip is so positioned that the at least one light source emits light incident on the at least one zone of the test strip, and so that light emanating from the at least one zone is incident on each photodetector.
a computation circuit, responsive to an input signal representing the amount of an analyte or the rate of accumulation of an analyte in at least one of the zones of the test strip, to:
compare the input signal to a first threshold;
compare the input signal to a second threshold, the second threshold being less than the first threshold;
generate an output signal if the input signal exceeds the first threshold or the input signal is less than the second threshold, the output signal indicative of a first result if the input signal exceeds the first threshold, or, alternatively, the output signal indicative of a second result if the input signal is less than the second threshold; and terminate the assay if the input signal exceeds the first threshold or the signal is less than the second threshold.
16. An assay result reading device for reading the result of an assay performed using a test strip, the device comprising:
at least one light source capable of emitting light incident upon at least one zone of the test strip; and at least two photodetectors, each of which detects light emanating from the at least one zone of the test strip.
17. A method of determining the result of an assay performed using a test strip, the method comprising:
positioning the test strip in relation to an assay result reader, the reader comprising a housing enclosing at least one light source and a photodetector; and measuring a light level received by the photodetector;
wherein the test strip is so positioned that the at least one light source emits light incident on at least two spatially separated zones of the test strip, and so that light emanating from at least one of the zones is incident on the photodetector.
18. A method according to claim 17, wherein the test strip is positioned at least partly inside the assay result reader.
19. A method according to claim 17 or 18, wherein the assay result reader further comprises a second photodetector, the at least one light source comprises first, second, and third light sources, the test strip has three spatially separated zones, and wherein:
each light source is aligned with and laterally offset from a corresponding test strip zone;
the first photodetector is so positioned as to receive light emanating from the first zone and the second zone; and the second photodetector is so positioned as to receive light emanating from the second zone and the third zone.
20. A method of determining the result of an assay performed using a test strip, the method comprising:
positioning the test strip in relation to an assay result reader, the reader comprising a housing enclosing at least one light source and at least two photodetectors; and measuring a light level received by the photodetector;
wherein the test strip is so positioned that the at least one light source emits light incident on the at least one zone of the test strip, and so that light emanating from the at least one zone is incident on each photodetector.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0312801A GB2402473A (en) | 2003-06-04 | 2003-06-04 | Analyte assay reading device involving sample flow rate measurement |
| GB0312801.2 | 2003-06-04 | ||
| US10/816,216 | 2004-04-01 | ||
| US10/816,216 US7315378B2 (en) | 2003-06-04 | 2004-04-01 | Optical arrangement for assay reading device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2468188A1 true CA2468188A1 (en) | 2004-12-04 |
| CA2468188C CA2468188C (en) | 2013-10-08 |
Family
ID=33566534
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2468188A Expired - Lifetime CA2468188C (en) | 2003-06-04 | 2004-05-21 | Optical arrangement for assay reading device |
Country Status (2)
| Country | Link |
|---|---|
| AU (1) | AU2004202382B2 (en) |
| CA (1) | CA2468188C (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2581988A (en) * | 2019-03-06 | 2020-09-09 | Sumitomo Chemical Co | Assay device |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU702209B2 (en) * | 1996-07-16 | 1999-02-18 | Roche Diagnostics Gmbh | Analytical system with means for detecting too small sample volumes |
| DE19639227B4 (en) * | 1996-09-24 | 2006-11-23 | Lre Technology Partner Gmbh | Method and device for blood glucose measurement |
| US6194222B1 (en) * | 1998-01-05 | 2001-02-27 | Biosite Diagnostics, Inc. | Methods for monitoring the status of assays and immunoassays |
-
2004
- 2004-05-21 CA CA2468188A patent/CA2468188C/en not_active Expired - Lifetime
- 2004-05-28 AU AU2004202382A patent/AU2004202382B2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CA2468188C (en) | 2013-10-08 |
| AU2004202382A1 (en) | 2004-12-23 |
| AU2004202382B2 (en) | 2009-11-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |