CA2445628A1 - Primary nucleotide sequence of the agrotis segetum granulosis virus (asgv), insecticide discovery systems containing this sequence and prevention and controlling kits for agrotis segetum insect outbreak and spread - Google Patents

Abstract

The present invention is based on the sequencing and assembly of the AsGV
genome.
The present invention provides the complete primary nucleotide sequence, and isolated fragments thereof, of the AsGV genome in a series of genomic and predicted transcript sequences. This information is provided in the form of sequences, annotation information, and computer-based systems, and can be used to generate insecticidal agents and nucleic acid and protein-based viral detection reagents and kits such as nucleic acid arrays.

Description

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PRIMARY NUCLEOTIDE SEQUENCE OF THE AGROTIS SEGETUM
GRANULOSIS VIRUS (AsGV), INSECTICIDE DISCOVERY SYSTEMS
CONTAINING THIS SEQUENCE AND PREVENTION AND CONTROLLING KITS
FOR AGROTIS SEGETUM INSECT OUTBREAK AND SPREAD
FIELD OF THE INVENTION
The present invention is in the field of genomic discovery systems and insecticide development. The present invention specifically provides the complete Agrotis segetum Granulosis Virus (AsGV) genome and isolated fragments thereof in a form that is commercially useful, including kits, pesticide agents, reagents such as nucleic acid arrays, and computer-based systems.
BACKGROUND OF THE INVENTION
Agrotis segetum belongs to a class of insects that eat a wide variety of food, which includes grain, cotton, oil, sugar and vegetables. It is a harmful insect to the crops. Its range extends over an area including Europe, Middle Asia, Russia and China. The insect specifically eats the young stem and root portion of a plant and damages agricultural products.
It destroys the sprout and can wipe out an entire crop if the density of the insects reaches 150 /m2. In 1989, in the area of Artai at Xinjiang, China, there were about 10,000,000 acres of farmland destroyed by this harmful insect.
In the past, Agrotis segetum was exterminated by using chemical pesticides.
However, chemical pesticides pollute the environment and are harmful to humans and to livestock. Recently, the Baculovirus has been used to exterminate the harmful insects, and it has become an important preventive technology in agriculture and forestry.
Such a technology has become adopted in many fields and has played a significant role in the environmental and ecological development.
Pesticides comprising Agrotis segetum Granulosis Virus, can replace chemical pesticides to exterminate the Agrotis Segetum. AsGV pesticide and the like are employed in various products such as grain, cotton, oil, melon, fruit, and vegetable products. The insect larva is killed after viral infection. In addition, AsGV pesticide also kills cutworms.
Therefore, AsGV pesticide provides an effective, non-toxic biological based pesticide.
So far there are very few reports about the genomic sequence of Agrotis segetum Granulosis Virus genome. Kozlov et al. from Ukraine sequenced granulosis protein of the virus. However, the sequence was detected by a method of random sequencing with no systemic or functional analysis. Although genomic sequence has been previously studied by one of the present inventors, the previously characterized sequence is only about l2Kb. The present invention provides a complete genomic sequence, which is more than 100 Kb. The present invention also provides structural analysis, including the detection of the expressed sequences and functional characterization. The present invention provided clones of cDNA/transcripts from whole DNA genomic sequence.
DNA Viruses AsGV is a double chain DNA virus. Generally, transcription of a DNA virus genome occurs in the nucleus of the host cell, utilizing host cell polymerases and other host enzymes for viral mRNA synthesis and viral replication. Viral gene transcription is modulated by the interaction of specific DNA-binding proteins with promoter and enhancer elements in the viral genome. Commonly, the viral promoter and enhancer elements are similar in sequence to those of the host cell in order to allow the host cell's transcriptional activation factors and DNA-dependent RNA polymerases to bind the viral control elements. Cells from different tissues or species express different DNA-binding proteins, and this is a major factor in determining which species, and which cells and tissues of that species, that the virus can infect.
Viruses, in general, depend on the host cell ribosomes, transfer RNA (tRNA), and mechanisms of posttranslational modification to produce their proteins.
Generally, viral mRNA encoding non-structural viral proteins, such as DNA-binding proteins and enzymes, are transcribed first. These are followed by late viral gene products encoding structural proteins.
Viruses utilize various methods to promote preferential translation of their viral mRNA over host cell mRNA. In some instances, concentration of viral mRNA in the host cell is so large that it occupies most of the cell's ribosomes, thereby preventing translation of host cell mRNA. Viruses may inhibit synthesis and/or induce degradation of the cell's nucleic acids. Many viruses increase the permeability of the host cell membrane, thereby reducing the ribosomal affinity for most cellular mRNA.
Viral DNA replication begins at a unique sequence in the genome called the origin of replication, or ori. The on is recognized by viral or host nuclear factors and DNA-dependent DNA polymerase. Viral DNA synthesis is semi-conservative and a primer is required by the DNA polymerase to initiate synthesis of the new DNA molecule.
Traditionally, the insect-virus based biological product is produced by infecting the virus to the hosts, wherein the virus is extracted from the host and made as pesticide after the virus has replicated in the live host. This procedure is complicated, time-consuming and has low efficiency. The complete viral genome sequence, including the regulatory and coding region of the present invention will improve the usage of AsGV as a pesticide agent. The present invention provides a viral lethal gene, and the production of protein by gene transfection and expression, because AsGV has protein content as high as 99.5%, one of the highest contents among all biological organisms. The present invention also provides a strong promoter of AsGV because the promoter can increase the expression of a chloramphenicol resistant gene up to 50 times. Therefore, the AsGV has great potential in the commercial market of agriculture business.
SUMMARY OF THE INVENTION
The present invention is based on the sequencing and assembly of the AsGV
genome.
The present invention provides the primary nucleotide sequence of the AsGV
genome (SEQ
>D NO: 1) and predicted transcript sequences (SEQ ID NOS: 2, 4, 6...214, 216:
See the Sequence Listing and the Figure Sheets for both the genomic and transcript sequences), and protein encoded sequence produced from each of the genes found in the AsGV
genome. This information is provided in the form of sequences and annotation information and can be used to generate computer based discovery systems, nucleic acid detection reagents and kits such as nucleic acid arrays, protein based detection kits, and insecticidal agents.
The sequencing of the fragment provides information of AsGV replication, expression, proliferation and the infection.
The present invention provides these nucleotide sequences of the AsGV genome, and representative fragments thereof, in a form that can be used, analyzed, and commercialized.
For example, the present invention provides the nucleic acid sequences as contiguous strings of primary sequences in a form readable by computers, such as recorded on computer readable media, e.g., magnetic storage media, such as floppy discs, hard disc storage medium, and magnetic tape; optical storage media such as CD-ROM; electrical storage media such as RAM and ROM; and hybrids of these categories such as magnetic/optical storage media. The present invention specifically provides a Sequence Listing in computer readable form stored on such media. Such compositions are useful in the discovery of insecticial agents.
The present invention further provides systems; particularly computer-based systems that contain the primary sequence information of the present invention stored in data storage means. Such systems are designed to identify commercially important fragments of the AsGV genome.

Another embodiment of the present invention is directed to isolated fragments, and collections of fragments, of the AsGV genome. The fragments of the AsGV genome include, but are not limited to, fragments that encode peptides, hereinafter open reading frames (ORFs) and fragments that modulate the expression of an operably linked ORF, hereinafter expression-modulating fragments (EMFs). The ORFs are provided in the Sequence Listing and in Figure 3.
The present invention further includes kits, such as nucleic acid arrays, detection reagents and microfluidic devices that comprise one or more fragments of the AsGV genome of the present invention, particularly ORFs. The kits, such as arrays, can be used to track the expression of many genes, even all genes, or rationally selected subsets thereof, contained in the AsGV genome.
The identification of the entire coding set of sequences from the genome of AsGV will be of great value to all laboratories working with this organism and for a variety of commercial and ecological purposes. Many fragments of the AsGV genome will be immediately identified by similarity searches against protein and nucleic acid databases and by identifying structural motifs present in protein domains and will be of immediate value to AsGV researchers and for commercial use of regulating AsGV infection in Agrotis segetum populations and potentially extending its host range. Proteins of this family can readily be configured into screens and assays for detecting chemical modulators of the protein activity.
The biological significance of this and other families of proteins for regulating insect reproduction is well known. Many of the known chemical agents modulate the activity of these types of proteins. The AsGV genome will allow one to identify all the genes involved in producing insecticidal agents and defining the host range of the pathogen.
The present invention is further directed to isolated AsGV proteins encoded by the ORFs of the present invention. A variety of methodologies known in the art can be utilized to obtain any one of the proteins of the present invention. The amino acid sequence can be synthesized using commercially available peptide synthesizers. In an alternative method, the viral protein can be purified from cells infected with the virus.
The invention further provides antibodies that selectively bind one of the AsGV
proteins encoded by the present invention. Antibodies have use in viral detection and can be generated using the protein encoding sequences provided by the present invention. Such antibodies include both monoclonal and polyclonal antibodies, and fragments thereof. The invention further provides hybridomas capable of producing the above-described monoclonal antibodies.

The present invention provides methods of identifying AsGV in a test sample, such as insects. Such methods comprise incubating cells extracted from the test sample with one or more of the antibodies or probes based on the nucleic acid sequences provided by the present invention under conditions that allow a skilled artisan to determine if the test sample contains the ORF or product produced therefrom. The method of detection also provides the information on the amount and the level of the AsGV infection.
Using the isolated proteins of the present invention, the present invention further provides methods of obtaining and identifying agents capable of binding to a protein encoded by one of the ORFs of the present invention. Specifically, such agents include antibodies, peptides, carbohydrates, pharmaceutical agents and the like. Such methods comprise the steps of contacting an agent with an isolated protein encoded by one of the ORFs of the present invention and determining whether the agent binds to said protein.
DESCRIPTION OF THE FIGURE SHEETS
Figure 1 provides a block diagram of a computer system 102 that can be used to implement the computer-based systems of the present invention.
Figure 2 (Sheet 1-31) provides the primary genomic sequence of AsGV.
Figure 3 (Sheets 1-108) provides:
1) Predicted transcript sequence of the AsGV gene and starting ATG site (SEQ ID NOS: 2, 4, 6...214, 216);

2) Predicted protein sequence of the AsGV gene (SEQ ID NOS: 3, 5, 7...21 S, 217);

3) Results of a BLAST query run using default parameters that shows proteins producing significant alignments with the predicted AsGV protein sequence of the present invention.

4) TaqMan primer/probe sets. Oligonucleotide sequences useful as primers and/or probes for amplifying and/or screening for the AsGV genes provided by the present invention.
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS
General Description The present invention is based on the sequencing and assembly of the AsGV
genome.
In this process, the primary nucleotide sequence of 106 nucleic acid fragments was determined. These fragments were assembled into a single contiguous sequence of 131,680 bp. After assembly, the sequences were analyzed with various computer packages and compared with all external data sources. The result of this analysis was the identification of 108 predicted genes/transcripts contained in the AsGV genome. The present invention provides the genomic nucleic acid sequence of AsGV (SEQ ID NO: 1), see Figure 2, Sheets 1-31, as well as the predicted gene structure of all 108 identified genes (SEQ
m NOS: 2, 4, 6...214, 216), and predicted amino acid sequences of all of the encoded proteins (SEQ ID
NOS: 3, 5, 7...215, 217), see Figure 3, sheets 1-108.
The nucleotide sequences of the present invention, or representative fragments thereof, are provided in a form that can be readily used, analyzed, and interpreted by a skilled artisan.
In one embodiment, the sequences are provided as contiguous strings of primary sequence information corresponding to the nucleotide sequences provided in the figures.
As used herein, a "representative fragment of the nucleotide sequence provided herein" refers to any portion of these sequences that are not presently represented within a publicly available database. Preferred representative fragments of the present invention are AsGV open reading frames and expression modulating fragments (ORFs and EMFs respectively, see figure 3 and below).
The nucleotide sequence information provided herein was obtained by sequencing the AsGV genome using a shotgun sequencing method known in the art. AsGV genomic DNA
was initially obtained for sequencing by extraction and purification of viral DNA from infected shrimp tissues using the method of Yang et al. (J. Virological Methods, 67:1-4 (1997)), which is hereby incorporated by reference. The nucleotide sequences provided herein are highly accurate, although not necessarily a 100% perfect, representation of the nucleotide sequence of the AsGV genome.
Using the information provided herein together with routine cloning and sequencing methods, one of ordinary skill in the art is able to identify, clone and sequence all "representative fragments" of interest including open reading frames (ORFs) encoding a large variety of AsGV proteins. In very rare instances, this may reveal a nucleotide sequence error present in the nucleotide sequence disclosed herein. Thus, once the present invention is made available (i.e., the information in the Sequence Listing and figures in a useable form), resolving a rare sequencing error would be well within the skill of the art.
Nucleotide sequence editing software is publicly available.
Even if all of the very rare sequencing errors in the sequences herein disclosed were corrected, the resulting nucleotide sequence would still be at least 90%
identical, and more likely 99% identical, and most likely 99.99% identical to the nucleotide sequence provided herein.
Thus, the present invention further provides nucleotide sequences that are at least 90%
identical, or greater, to the nucleotide sequences of the present invention in a form that can be readily used, analyzed and interpreted by the skilled artisan. Methods for determining whether a nucleotide sequence is at least 90% identical to the nucleotide sequence of the present invention are routine and readily available to the skilled artisan.
For example, the well known BLAST algorithm can be used to generate the percent identity of nucleotide sequences.
The present invention further provides a prediction of all of the genes within the AsGV genome. This information is provided in Figure 3. The information in the figures can be used to generate AsGV detection kits, insecticidal agents, expression arrays, microfluidic devices, individual gene fragments, proteins, antibodies, promoters, protein and nucleotide based viral screens and the like, and to identify commercially important genes and gene products.
Specific Embodiments Computer Related Embodiments The nucleotide sequences provided in the present invention, a representative fragment thereof, or nucleotide sequences at least 90% identical to these sequences, may be "provided"
in a variety of mediums to facilitate use thereof. As used herein, "provided"
refers to a manufacture, other than an isolated nucleic acid molecule, that contains a nucleotide sequence of the present invention, i.e., the nucleotide sequences provided in the present invention, a representative fragment thereof, or nucleotide sequences at least 90%
identical to these sequences. Such a manufacture provides the AsGV genome or a subset thereof (e.g., a AsGV
open reading frame (ORF)) in a form that allows a skilled artisan to examine the manufacture using means not directly applicable to examining the AsGV genome or a subset thereof as it exists in nature or in purified form.
In one application of this embodiment, a nucleotide sequence of the present invention can be recorded on computer readable media. As used herein, "computer readable media"
refers to any medium that can be read and accessed directly by a computer.
Such media include, but are not limited to: magnetic storage media, such as floppy discs, hard disc storage medium, and magnetic tape; optical storage media such as CD-ROM; electrical storage media such as RAM and ROM; and hybrids of these categories such as magnetic/optical storage media. A skilled artisan can readily appreciate how any of the presently known computer readable mediums can be used to create a manufacture comprising computer readable medium having recorded thereon a nucleotide sequence of the present invention. One such medium is provided with the present application, namely, the present application contains computer readable medium (CD-R) that has the sequence contigs provided/recorded thereon in ASCII
text format in a Sequence Listing.
As used herein, "recorded" refers to a process for storing information on computer readable medium. A skilled artisan can readily adopt any of the presently known methods for recording information on computer readable medium to generate manufactures comprising the nucleotide sequence information of the present invention.
A variety of data storage structures are available to a skilled artisan for creating a computer readable medium having recorded thereon a nucleotide or amino acid sequence of the present invention. The choice of the data storage structure will generally be based on the means chosen to access the stored information. In addition, a variety of data processor programs and formats can be used to store the nucleotide sequence information of the present invention on computer readable medium. The sequence information can be represented in a word processing text file, formatted in commercially-available software such as WordPerfect and Microsoft Word, or represented in the form of an ASCII file, stored in a database application, such as OB2, Sybase, Oracle, or the like. A skilled artisan can readily adapt any number of data processor structuring formats (e.g. text file or database) in order to obtain computer readable medium having recorded thereon the nucleotide sequence information of the present invention.
By providing the nucleotide sequences of the present invention, a representative fragment thereof, or nucleotide sequences at least 90% identical to these sequences, in computer readable form, a skilled artisan can routinely access the sequence information for a variety of purposes. Computer software is publicly available which allows a skilled artisan to access sequence information provided in a computer readable medium. Software which implements the BLAST (Altschul et at, J. Mol. Biol. 215:403-410 (1990)) and BLAZE
(Brutlag et at, Comp. Chem. 17:203-207 (1993)} search algorithms on a Sybase system an be used to identify open reading frames (ORFs) within the AsGV genome that contain homology to ORFs or proteins from other organisms. Such ORFs are protein-encoding fragments within the AsGV genome and are useful in producing commercially important proteins such as proteins used as insecticidal agents.

The present invention further provides systems, particularly computer-based systems, which contain the sequence information described herein. Such systems are designed to identify commercially important fragments of the AsGV genome.
As used herein, "a computer-based system" refers to the hardware means, software means, and data storage means used to analyze the nucleotide sequence information of the present invention. The minimum hardware means of the computer-based systems of the present invention comprises a central processing unit (CPL, input means, output means, and data storage means. A skilled artisan can readily appreciate that any one of the currently available computer-based system are suitable for use in the present invention.
Such system can be changed into a system of the present invention by utilizing the sequence information provided on the CD-R, or a subset thereof without any experimentation.
As stated above, the computer-based systems of the present invention comprise a data storage means having stored therein a nucleotide sequence of the present invention and the necessary hardware means and software means for supporting and implementing a search means. As used herein, "data storage means" refers to memory which can store nucleotide sequence information of the present invention, or a memory access means which can access manufactures having recorded thereon the nucleotide sequence information of the present invention.
As used herein, "search means" refers to one or more programs that are implemented on the computer-based system to compare a target sequence or target structural motif with the sequence information stored within the data storage means. Search means are used to identify fragments or regions of the AsGV genome that match a particular target sequence or target motif. A variety of known algorithms are disclosed publicly and a variety of commercially available software for conducting search means are available and can be used in the computer-based systems of the present invention. Examples of such software include, but are not limited to, MacPattem (EMBL), BLASTN and BLASTX (NCBIA). A skilled artisan can readily recognize that any one of the available algorithms or implementing software packages for conducting homology searches can be adapted for use in the present computer-based systems.
As used herein, a "target sequence" can be any DNA or amino acid sequence of six or more nucleotides or two or more amino acids. A skilled artisan can readily recognize that the longer a target sequence is, the less likely a target sequence will be present as a random occurrence in the database. The most preferred sequence length of a target sequence is from about 10 to 100 amino acids or from about 30 to 300 nucleotide residues.
However, it is well recognized that searches for commercially important fragments of the AsGV
genome, such as sequence fragments involved in gene expression and protein processing, may be of shorter length.
As used herein, "a target structural motif," or "target motif," refers to any rationally selected sequence or combination of sequences in which the sequences) is chosen based on a three-dimensional configuration that is formed upon the folding of the target motif. There are a variety of target motifs known in the art. Protein target motifs include, but are not limited to, enzymatic active sites and signal sequences. Nucleic acid target motifs include, but are not limited to, promoter sequences, hairpin structures and inducible expression elements (protein binding sequences).
A variety of structural formats for the input and output means can be used to input and output the information in the computer-based systems of the present invention.
A preferred format for an output means ranks fragments of the AsGV genome possessing varying degrees of homology to the target sequence or target motif. Such presentation provides a skilled artisan with a ranking of sequences, which contain various amounts of the target sequence or target motif, and identifies the degree of homology contained in the identified fragment.
A variety of comparing means can be used to compare a target sequence or target motif with the data storage means to identify sequence fragments of the AsGV
genome.
Software that implements the BLAST and BLAZE algorithms (Altschul et al., J
Mol. Biol.
215:403-410 (1990)) can be used to identify open reading frames within the AsGV genome.
A skilled artisan can readily recognize that any one of the publicly available homology search programs can be used as the search means for the computer-based systems of the present invention.
One application of this embodiment is provided in Figure 1. Figure 1 provides a block diagram of a computer system 102 that can be used to implement the present invention. The computer system 102 includes a processor 106 connected to a bus 104. Also connected to the bus 104 are a main memory 108 (preferably implemented as random access memory, RAM) and a variety of secondary storage devices 110, such as a hard drive 112 and a removable medium storage device 114. The removable medium storage device 114 may represent, for example, a floppy disk drive, a CD- ROM drive, a magnetic tape drive, etc. A
removable storage medium 116 (such as a floppy disk, a compact disk, a magnetic tape, etc.) containing control logic and/or data recorded therein may be inserted into the removable medium storage device 114. The computer system 102 includes appropriate software for reading the control logic and/or the data from the removable storage medium 116 once inserted in the removable medium storage device 114.
The nucleotide sequences of the present invention may be stored in a well known manner in the main memory 108, any of the secondary storage devices 110, and/or a removable storage medium 116. Software for accessing and processing the genomic sequence (such as search tools, comparing tools, etc.) reside in main memory 108 during execution.
Nucleic Acid Fray Another embodiment of the present invention is directed to isolated fragments of the AsGV genome. The fragments of the AsGV genome of the present invention include, but are not limited to, fragments that encode peptides, hereinafter open reading frames (ORFs) and fragments which modulate the expression of an operably linked ORF. Some of these fragments are identified and described in Figure 3. The isolated nucleic acid molecules of the present invention include, but are not limited to, single stranded and double stranded DNA, and single stranded RNA.
"Nucleotide sequence" refers to a heteropolymer of deoxyribonucleotides.
Generally, DNA segments encoding the polypeptides and proteins provided by this invention are assembled from fragments of the AsGV genome or single nucleotides, short oligonucleotide linkers, or from a series of oligonucleotides, to provide a synthetic nucleic acid molecule.
As used herein, an "isolated nucleic acid molecule" or an "isolated fragment of the AsGV genome" refers to a nucleic acid molecule possessing a specific nucleotide sequence which has been subjected to purification means to reduce, from the composition, the number of compounds which are normally associated with the composition. A variety of purification means can be used to generate the isolated fragments of the present invention.
These include, but are not limited to, methods that separate constituents of a solution based on charge, solubility, or size.
In one embodiment, AsGV DNA can be mechanically sheared to produce fragments of about 2kb, l Okb, or 15-20 kb in length. These fragments can then be used to generate an AsGV library by inserting them into vectors, such as plasmid or lambda vectors, using methods well known in the art. Primers flanking each fragment, for example an ORF, can then be generated using nucleotide sequence information provided in the present invention.
PCR cloning can then be used to isolate the ORF from the AsGV DNA library. PCR
cloning is well known in the art. Thus, given the availability of the present identified gene coding sequences of the AsGV genome, it is routine experimentation to isolate any ORF, or other fragment of the assembly of the present invention, particularly using the information provided in Figure 3. Such fragments can be applied to an array, microfluidic device, or other detection kit format and used to detect expression of a viral gene (see below).
As used herein, an "open reading frame" (ORF) means a series of triplets coding for amino acids without any termination codons and is a sequence translatable into protein. A
skilled artisan can readily identify ORFs in the AsGV genome using the gene coding sequences provided herein and/or the computer-based systems of the present invention.
As used herein, an "expression modulating fragment" (EMF) means a series of nucleotide molecules which modulates the expression of an operably linked ORF
or another EMF.
As used herein, a viral sequence is said to "modulate the expression of an operably linked sequence" when the expression of the sequence is altered by the presence of the EMF.
EMFs include, but are not limited to, promoters, and promoter modulating sequences (inducible elements). One class of viral EMFs is fragments that induce the expression of an operably linked viral ORF in response to a specific host regulatory factor or physiological event, such as a host anti-viral response.
EMF sequences can be identified within the AsGV genome by their proximity to the ORFs identified using the computer-based systems of the present invention.
EMFs may be found immediately S' to the ORF. Alternatively, EMFs can be identified using known EMFs as a target sequence or target motif in the computer-based systems of the present invention.
The presence and activity of an EMF can be confirmed using an EMF trap vector.
An EMF trap vector contains a cloning site S' to a marker sequence. A marker sequence encodes an identifiable phenotype, such as antibiotic resistance or a complementing nutrition auxotrophic factor, which can be identified or assayed when the EMF trap vector is placed within an appropriate host under appropriate conditions. An EMF will modulate the expression of an operably linked marker sequence. A sequence that is suspected of being an EMF is cloned in all three reading frames in one or more restriction sites upstream from the marker sequence in the EMF trap vector. The vector is then transformed into an appropriate host using known procedures and the phenotype of the transformed host is examined under appropriate conditions.
The sequences falling within the scope of the present invention are not limited to the specific sequences herein described, but also include variations thereof.
Variations can be routinely determined by comparing the sequence provided in the present invention, or a representative fragment thereof, with a sequence from another AsGV isolate.
Furthermore, to accommodate the degeneracy of the genetic code, the invention includes nucleic acid molecules coding for the same amino acid sequences as do the specific ORFs disclosed herein. In other words, in the coding region of an ORF, substitution of one codon for another that encodes the same amino acid is expressly contemplated.
Any specific sequence disclosed herein can be readily screened for errors by resequencing a particular fragment, such as an ORF, in both directions (i.e., sequence both strands). Alternatively, error screening, or variant detection, can be performed by sequencing corresponding polynucleotides of AsGV origin isolated by using part or all of the fragments in question as a probe or primer.
Nucleic Acid Fragment Uses The nucleic acid molecules of the present invention are useful for probes, primers, chemical intermediates, and in biological assays. The nucleic acid molecules are usefizl as hybridization probes for viral messenger RNA, viral transcript/cDNA, and viral genomic DNA
to isolate full-length viral cDNA and viral genomic clones encoding the peptides described in Figure 3, and for use in viral screens and pesticide agents.
Oligonucleotide probes have long been used to detect complementary nucleic acid sequences in a nucleic acid of interest (the "target" nucleic acid) in the form of detection kits/reagents. In some assay formats, the oligonucleotide probe is tethered, i.e., by covalent attachment, to a solid support, and arrays of oligonucleotide probes immobilized on solid supports have been used to detect specific nucleic acid sequences in a target nucleic acid. See, e.g., PCT patent publication Nos. WO 89/10977 and 89/11548. In other formats, the detection reagents are supplied in solution.
The probe can correspond to any sequence along the entire length of the nucleic acid molecules provided in the figures. However, as discussed, fragments are not to be construed as encompassing fi~agments disclosed prior to the present invention.
Each of the ORFs of the AsGV genome that can be routinely identified using the computer system of the present invention can be used in numerous ways as polynucleotide reagents. The sequences can be used as diagnostic probes or diagnostic amplification primers to detect the expression of a particular gene or groups of genes. This is particularly useful in the form of nucleic acid arrays employing 1 or more, 10 or more, 100 or more, or most to all of the AsGV ORFs in a single array.
The nucleic acid molecules are also useful as primers for PCR to amplify any given region of a nucleic acid molecule and are useful for synthesizing antisense molecules of desired length and sequence.

The nucleic acid molecules are useful as primers for the 5' nuclease PCR assay (hereafter referred to as the TaqMan assay). The TaqMan assay provides a sensitive and rapid means of detecting viral nucleic acid and therefore is well suited for use in viral screening applications such as detection kits. The TaqMan assay detects the accumulation of a specific amplified product during PCR. The TaqMan assay utilizes an oligonucleotide probe labeled with a fluorescent reporter dye at the 5' end of the probe and a quencher dye at the 3' end of the probe. During the PCR reaction, the 5' nuclease activity of DNA polymerase cleaves the probe, thereby separating the reporter dye and the quencher dye and resulting in increased fluorescence of the reporter. Accumulation of PCR product is detected directly by monitoring the increase in fluorescence of the reporter dye. The 5' nuclease activity of DNA polymerase cleaves the probe between the reporter and the quencher only if the probe hybridizes to the target and is amplified during PCR. Therefore, only the target sequence of interest is detected.
Preferred TaqMan primer and probe sequences are disclosed in Figure 3. It will be apparent to one of skill in the art that the disclosed primers and probes of the present invention are useful as diagnostic probes or amplification primers for screening for the presence of AsGV in a biological sample or for isolating or screening particular AsGV genes.
The nucleic acid molecules are also useful for expressing antigenic portions of the AsGV
proteins that can then be used, for example, to develop antibodies to the viral antigens.
The nucleic acid molecules are also useful as hybridization probes for determining the presence, level, form and distribution of AsGV nucleic acid expression.
Accordingly, the probes can be used to detect the presence of, or to determine levels of, a specific viral nucleic acid molecule, either DNA or RNA, in cells and tissues of AsGV or other organisms under moderate or stringent conditions. One example of stringent hybridization conditions are hybridization in 6X sodium chloride/sodium citrate (SSC) at about 45 °C, followed by one or more washes in 0.2 X SSC, 0.1 % SDS at 50-65 °C. Examples of moderate to low stringency hybridization conditions are well known in the art. Furthermore, probes corresponding to the viral peptides described herein can be used to assess expression and/or gene copy number in a given infected cell, tissue, or organism. For example, Northern blots can be used for RNA
detection, Southern blots can be used for DNA detection, and Western blots can be used for peptide/protein detection. These uses are relevant for detecting the presence of virus in insects as well as for monitoring the distribution of virus throughout various cells and tissues of insects during the course of viral infection.
In addition, each of the expression modulating fi~agments (EMFs) can be used in DNA-protein binding assays to screen for modulating peptides that may be present in cells and tissues of AsGV or other organisms. This use is relevant for obtaining the specific host regulatory factors that interact with promoters in the AsGV genome.
Nucleic acid expression assays are also useful for identifying nucleic acid expression involved in insecticidal protein production and host specificity. The method typically includes determining which genes, through expression analysis, are activate during host infection cycles and insecticidal agent production. The assays can be performed in cell-based and cell-free systems. Cell-based assays include cells infected with virus particles or recombinant cells genetically engineered to express specific viral nucleic acid sequences. Cell-free assays can be used to detect the ability of a compound to directly bind to a nucleic acid fragment or protein.
The assay for viral nucleic acid expression can involve direct assay of nucleic acid levels, such as mRNA levels, or on collateral compounds involved in the signal pathway. Furthermore, the expression of host cell genes that are up- or down-regulated in response to the viral protein can also be assayed. In this embodiment the regulatory regions of these genes can be operably linked to a reporter gene such as luciferase.
Thus, modulators of viral gene expression can be identified by a method wherein a cell infected with virus is contacted with a candidate compound and the expression of viral mRNA
determined. The level of expression of viral mRNA in the presence of the candidate compound is compared to the level of expression of viral mRNA in the absence of the candidate compound.
The candidate compound can then be identified as a modulator of viral nucleic acid expression based on this comparison and be used, for example, to disrupt viral replication. When expression of viral mRNA is statistically significantly greater in the presence of the candidate compound than in its absence, the candidate compound is identified as a stimulator of viral nucleic acid expression. When viral nucleic acid expression is statistically significantly less in the presence of the candidate compound than in its absence, the candidate compound is identified as an inhibitor of viral nucleic acid expression.
The nucleic acid molecules are also useful as antisense constructs to control viral gene expression in infected cells and tissues. A DNA antisense nucleic acid molecule is designed to be complementary to, and therefore bind to, a region of the viral gene necessary for transcription, thereby preventing transcription and hence production of viral protein. An antisense RNA or DNA nucleic acid molecule would hybridize to the viral mRNA and thus block translation of viral mRNA into protein by the host cell's translational machinery.
The nucleic acid molecules of the present invention can be employed to create transgenic viral sensitive Agrotis segetum insect. Several possible mechanisms could be employed to impart AsGV resistance to Agrotis segetum insect using the nucleic acid and protein coding sequences provided by the present invention. One possible mechanism of imparting AsGV
sensitive to Agrotis segetum insect involves transforming insect cells with viral nucleic acids that express an attenuated virion coat protein such that when the transgenic insect is infected with AsGV, the expressed coat protein envelopes the virus and thereby prevents translation of the viral DNA. In this example, the virion coat protein can either be constitutively expressed or regulated by a promoter that is activated upon AsGV infection. Insect cells can be transformed with viral DNA under suitable conditions known in the art. The AsGV construct in a vector can be microinjected directly into host cells using micropipettes, Crossway, Mol.
Gen. Genetics, 202:179-85 (1985), or using polyethylene glycol, Krens et al., Nature, 296:72-74 (1982).
Alternatively, insect cells may be transformed by incubating the insect cells or tissue with an inoculum of bacteria that have been transformed with a vector comprising a gene that imparts AsGV sensitivity. The transformed insect cells are then grown and regenerated into Agrotis segetum such that the proteins expressed by the transformed cells impart AsGV
sensitivity to the insect.
Nucleic Acid Arrays and Detection Reagents The present invention further provides detection reagents and kits, such as arrays or microarrays, of nucleic acid molecules that are based on the novel AsGV
sequence information provided in the present invention and particularly the transcript information (SEQ
ID NOS: 2, 4, 6...214, 216) provided in Figure 3.
As used herein "Arrays" or "Microarrays" refers to an array of distinct polynucleotides or oligonucleotides synthesized on a substrate, such as paper, nylon or other type of membrane, filter, chip, glass slide, or any other suitable solid, or semi-solid support. The development of arraying technologies such as photolithographic synthesis of a nucleic acid array and high density spotting of cDNA products has provided methods for making very large arrays of oligonucleotide probes in very small areas. See U.S. Pat. No.

5,143,854 and PCT patent publication Nos. WO 90/15070 and 92/10092. Microfabricated arrays of large numbers of oligonucleotide probes, called "DNA chips", offer great promise for a wide variety of applications. In one embodiment, the microarray is prepared and used according to the methods described in US Patent 5,837,832, Chee et al., PCT application (Chee et al.), Lockhart, D. J. et al. (1996; Nat. Biotech. 14: 1675-1680) and Schena, M. et al.
(1996; Proc. Natl. Acad. Sci. 93: 10614-10619), all of which are incorporated herein in their entirety by reference. In other embodiments, such arrays are produced by the methods described by Brown et al., US Patent No. 5,807,522.

The microarray or detection kit is preferably composed of a large number of unique, single-stranded nucleic acid sequences, usually either synthetic antisense oligonucleotides or fragments of cDNAs, fixed to a solid support. The oligonucleotides are preferably about 6-60 nucleotides in length, more preferably 15-30 nucleotides in length, and most preferably about 20-25 nucleotides in length. For a certain type of microarray or detection kit, it may be preferable to use oligonucleotides that are only 7-20 nucleotides in length.
For others, such as cDNA, longer lengths are possible and preferable. These can be of the order of lkb or more.
The microarray or detection kit may contain oligonucleotides that cover the known 5' or 3' sequence, sequential oligonucleotides that cover the full-length sequence; or unique oligonucleotides selected from particular areas along the length of the sequence.
Polynucleotides used in the microarray or detection kit may be oligonucleotides that are specific to a viral gene or genes of interest.
In order to produce oligonucleotides to a known sequence for a microarray or detection kit, the viral genes) of interest (or an ORF identified from the contigs of the present invention) is typically examined using a computer algorithm which starts at the 5' or at the 3' end of the nucleotide sequence. Typical algorithms will then identify oligomers of defined length that are unique to the gene, have a GC content within a range suitable for hybridization, and lack predicted secondary structure that may interfere with hybridization. In certain situations it may be appropriate to use pairs of oligonucleotides on a microarray or detection kit. The "pairs" will be identical, except for one nucleotide that preferably is located in the center of the sequence. The second oligonucleotide in the pair (mismatched by one) serves as a control. The number of oligonucleotide pairs may range from one to two millions.
The oligomers are synthesized at designated areas on a substrate using a light-directed chemical process. The substrate may be paper, nylon or other type of membrane, filter, chip, glass slide or any other suitable solid support.
In another aspect, an oligonucleotide may be synthesized on the surface of the substrate by using a chemical coupling procedure and an ink jet application apparatus, as described in PCT application W095/251116 (Baldeschweiler et al.) which is incorporated herein in its entirety by reference. In another aspect, a "gridded" array analogous to a dot (or slot) blot may be used to arrange and link cDNA fragments or oligonucleotides to the surface of a substrate using a vacuum system, thermal, LJV, mechanical or chemical bonding procedure. An array, such as those described above, may be produced by hand or by using available devices (slot blot or dot blot apparatus), materials (any suitable solid support), and machines (including robotic instruments), and may contain 8, 24, 96, 384, 1536, 6144 or more 1~

oligonucleotides, or any other number which lends itself to the efficient use of commercially available instrumentation.
In other embodiments, the array or detection reagent/kit can be produced by spotting a nucleic acid molecule onto the surface of a substrate (See Brown et. al., US
Patent No.
5,807,522). In such embodiments, PCR primers to one or more nucleic acid fragments are used to generate nucleic acid molecules suitable for deposition onto a substrate.
In order to conduct sample analysis using a microarray or detection kit, viral nucleic acid is isolated from a biological sample infected with AsGV and the viral nucleic acid is made into hybridization probes. Viral nucleic acid may be isolated from biological samples obtained from fluids, cultured cells, biopsies, or other tissue preparations from an insect or other organism of interest that is infected with AsGV. Viral mRNA is isolated, and cDNA is produced and used as a template to make antisense RNA (aRNA). The aRNA is amplified in the presence of fluorescent nucleotides, and labeled probes are incubated with the microarray or detection kit so that the probe sequences hybridize to complementary oligonucleotides of the microarray or detection kit. Incubation conditions are adjusted so that hybridization occurs with precise complementary matches or with various degrees of less complementarity.
After removal of nonhybridized probes, a scanner is used to determine the levels and patterns of fluorescence. The scanned images are examined to determine degree of complementarity and the relative abundance of each oligonucleotide sequence on the microarray or detection kit. A detection system may be used to measure the absence, presence, and amount of hybridization for all of the distinct viral sequences simultaneously. This data may be used for large-scale correlation studies on the sequences, expression patterns, mutations, variants, or polyrnorphisms among viral isolates.
Using such arrays, the present invention provides methods to identify the expression of one or more of the ORFs of the present invention. In detail, such methods comprise incubating a test sample with one or more nucleic acid molecules and assaying for binding of the nucleic acid molecule with components within the test sample. Such assays will typically involve arrays comprising most, if not all of the genes in the AsGV genome, or rationally selected subsets thereof. The genomic sequence (SEQ ID NO: 1) and transcript sequences (SEQ ID NOS: 2, 4, 6...214, 216) of the AsGV genome of the present invention are provided in Figure 2 and Figure 3.
Conditions for incubating a nucleic acid molecule with a test sample vary.
Incubation conditions depend on the format employed in the assay, the detection methods employed, and the type and nature of the nucleic acid molecule used in the assay. One skilled in the art will 1s recognize that any one of the commonly available hybridization, amplification or array assay formats can readily be adapted to employ the novel fragments of the AsGV
genome disclosed herein. Examples of such assays can be found in Chard, T, An Introduction to Radioimmunoassay and Related Techniques, Elsevier Science Publishers, Amsterdam, The Netherlands (1986); Bullock, G. R. et al., Techniques in Immunocytochemistry, Academic Press, Orlando, FL Vol. 1 (1982), Vol. 2 (1983), Vol. 3 (1985); Tijssen, P., Practice and Theory of Enryme Immunoassays: Laboratory Techniques in Biochemistry and Molecular Biology, Elsevier Science Publishers, Amsterdam, The Netherlands (1985).
The test samples of the present invention include, but are not limited to, nucleic acid extracts, cells, and protein or membrane extracts of cells infected with AsGV.
The test sample used in the above-described method will vary based on the assay format, the nature of the detection method, and the tissues, cells, or extracts used as the sample to be assayed.
Methods for preparing nucleic acid extracts or for preparing cells are well known in the art and can readily be adapted in order to obtain a sample that is compatible with the system utilized.
In another embodiment of the present invention, kits are provided which contain the necessary reagents to carry out the assays of the present invention.
Specifically, the invention provides a compartmentalized kit to receive, in close confinement, one or more containers which comprises: (a) a first container comprising one of the nucleic acid molecules that can bind to a fragment of the AsGV genome disclosed herein;
and (b) one or more other containers comprising one or more of the following:
wash reagents, reagents capable of detecting the presence of a bound nucleic acid. Preferred kits will include detection reagents/arrays/chips/microfluidic devices that are capable of detecting the expression of 1 or more, 10 or more, 100 or more, or most or all of the genes expressed in AsGV, particularly the genes provided in Figure 3.
In detail, a compartmentalized kit includes any kit in which reagents are contained in separate containers. Such containers include small glass containers, plastic containers, strips of plastic, glass or paper, or arraying material such as silica. Such containers allow one to efficiently transfer reagents from one compartment to another compartment such that the samples and reagents are not cross contaminated, and the agents or solutions of each container can be added in a quantitative fashion from one compartment to another. Such containers may include a container that will accept the test sample, a container that contains the nucleic acid probe, containers which contain wash reagents (such as phosphate buffered saline, Tris-buffers, etc.), and containers which contain the reagents used to detect the bound probe. One skilled in the art will readily recognize that the previously unidentified ORFs that can be routinely identified using the sequence information disclosed herein can be readily incorporated into one of the established kit formats which are well known in the art, particularly expression arrays.
Protein/P~tide Molecules The present invention provides nucleic acid sequences that encode AsGV protein molecules (Figure 3). The peptide sequences provided in Figure 3, as well as the obvious variants described herein, and using the information in Figure 3, will be referred to herein as the AsGV peptides of the present invention or peptides/polypeptides/proteins of the present invention.
Enzymes and other viral proteins are produced during viral activity and replication and can be used as targets for screening and quantitating a particular virus, or in developing insecticidal agents. Like viruses in general, AsGV utilizes the resources of the host cell for production of viral proteins. Viral proteins can be detected using an antibody, or binding portion thereof, to the protein or a probe that recognizes proteins or peptides of the present invention. Viral antigens present either on the surface or within the infected cell can be detected by various antibody tests, including immunoflourescence or enzyme immunoassay (EIA). Virus or antigen released from infected cells can be detected by such antibody tests as enzyme linked immunosorbent assay (ELISA), radioimmunoassay (RIA), or latex agglutination (LA). Protein-based tests such as these for AsGV antigens are useful for detecting the infection of AsGV in Agrotis segetum populations.
The present invention provides isolated peptide and protein molecules that comprise, consist essentially of, or consist of the amino acid sequences of the AsGV
peptides disclosed in Figure 3, (which are encoded by the transcript sequences that are also shown in Figure 3), as well as all obvious variants of these peptides that are within the art to make and use. Some of these variants are described in detail below.
As used herein, a peptide is said to be "isolated" or "purified" when it is substantially free of cellular material or free of chemical precursors or other chemicals.
The peptides of the present invention can be purified to homogeneity or other degrees of purity.
The level of purification will be based on the intended use. The critical feature is that the preparation allows for the desired function of the peptide, even if in the presence of considerable amounts of other components.

In some uses, "substantially free of cellular material" includes preparations of the peptide having less than about 30% (by dry weight) other proteins (i.e., contaminating protein), less than about 20% other proteins, less than about 10% other proteins, or less than about 5% other proteins. When the peptide is recombinantly produced, it can also be substantially free of culture medium, i.e., culture medium represents less than about 20% of the volume of the protein preparation.
The language "substantially free of chemical precursors or other chemicals"
includes preparations of the peptide in which it is separated from chemical precursors or other chemicals that are involved in its synthesis. In one embodiment, the language "substantially free of chemical precursors or other chemicals" includes preparations of a AsGV
peptide having less than about 30% (by dry weight) chemical precursors or other chemicals, less than about 20%
chemical precursors or other chemicals, less than about 10% chemical precursors or other chemicals, or less than about 5% chemical precursors or other chemicals.
An isolated AsGV peptide can be purified fi-om cells infected with AsGV, purified from cells that have been altered to express it (recombinant), or synthesized using known protein synthesis methods. For example, a nucleic acid molecule encoding the peptide can be cloned into an expression vector, the expression vector introduced into a host cell, and the protein expressed in the host cell. The protein can then be isolated from the host cells by an appropriate purification scheme using standard protein purification techniques. Many of these techniques are described in detail below.
Accordingly, the present invention provides proteins that consist of the amino acid sequences provided in Figure 3 (SEQ >D NOS: 3, 5, 7...215, 217), for example, proteins encoded by the transcript/cDNA nucleic acid sequences also shown in Figure 3 (SEQ )D
NOS: 2, 4, 6...214, 216). A protein consists of an amino acid sequence when the amino acid sequence is the final amino acid sequence of the protein.
The present invention fiuther provides proteins that consist essentially of the amino acid sequences provided in Figure 3 (SEQ )D NOS: 3, 5, 7...215, 217), for example, proteins encoded by the transcript/cDNA nucleic acid sequences also shown in Figure 3 (SEQ ID
NOS: 2, 4, 6...214, 216). A protein consists essentially of an amino acid sequence when such an amino acid sequence is present with only a few additional amino acid residues, for example finm about 1 to about 100 or so additional residues, typically from 1 to about 20 additional residues in the final protein.
The present invention fizrther provides proteins that comprise the amino acid sequences provided in Figure 3 (SEQ >I7 NOS: 3, S, 7...215, 217), for example, proteins encoded by the transcript/cDNA nucleic acid sequences also shown in Figure 3 (SEQ ID NOS: 2, 4, 6...214, 216). A protein comprises an amino acid sequence when the amino acid sequence is at least part of the final amino acid sequence of the protein. In such a fashion, the protein can be only the peptide or have additional amino acid molecules, such as amino acid residues (contiguous encoded sequence) that are naturally associated with it or heterologous amino acid residues/peptide sequences. Such a protein can have a few additional amino acid residues or can comprise several hundred or more additional amino acids. The preferred classes of proteins that are comprised of the peptides of the present invention are the naturally occurring mature proteins. A brief description of how various types of these proteins can be made/isolated is provided below.
The peptides of the present invention can be attached to heterologous sequences to form chimeric or fission proteins. Such chimeric and fusion proteins comprise an AsGV peptide operatively linked to a heterologous protein having an amino acid sequence not substantially homologous to the AsGV peptide. "Operatively linked" indicates that the AsGV
peptide and the heterologous protein are fused in-frame. The heterologous protein can be fused to the N-terminus or C-terminus of the AsGV peptide.
In some uses, the fusion protein does not affect the activity of the AsGV
peptide per se.
For example, the fusion protein can include, but is not limited to, enzymatic fizsion proteins, for example beta-galactosidase fi~sions, yeast two-hybrid GAL fi~sions, poly His fusions, MYC-tagged, HI-tagged and Ig fusions. Such fusion proteins, particularly poly-His fitsions, can facilitate the purification of recombinant AsGV peptide. In certain host cells, expression and/or secretion of a protein can be increased by using a heterologous signal sequence.
A chimeric or fission protein can be produced by standard recombinant DNA
techniques.
For example, DNA fi~agments coding for the different protein sequences are ligated together in-frame in accordance with conventional techniques. In another embodiment, the fusion gene can be synthesized by conventional techniques including automated DNA
synthesizers.
Alternatively, PCR amplification of gene fragments can be carried out using anchor primers which give rise to complementary overhangs between two consecutive gene fragments which can subsequently be annealed and re-amplified to generate a chimeric gene sequence (see Ausubel et al., Current Protocols in Molecular Biology, 1992). Moreover, many expression vectors are commercially available that already encode a fusion moiety (e.g., a GST protein). A
AsGV peptide-encoding nucleic acid can be cloned into such an expression vector such that the fizsion moiety is linked in-frame to the AsGV peptide.

As mentioned above, the present invention also provides and enables obvious variants of the amino acid sequence of the proteins of the present invention, such as naturally occurring mature forms of the peptide, sequence variants of the peptides, non-naturally occurring recombinantly derived variants of the peptides, and orthologs and paralogs of the peptides. Such variants can readily be generated using art-known techniques in the fields of recombinant nucleic acid technology and protein biochemistry. It is understood, however, that variants exclude any amino acid sequences disclosed prior to the invention.
Such variants can readily be identified/made using molecular techniques and the sequence information disclosed herein. Further, such variants can readily be distinguished from other peptides based on sequence and/or structural homology to the AsGV
peptides of the present invention. The degree of homology/identity present will be based primarily on whether the peptide is a fimctional variant or non-fixnctional variant, the amount of divergence present in the paralog protein family and the evolutionary distance between orthologous viruses.
To determine the percent identity of two amino acid sequences or two nucleic acid sequences, the sequences are aligned for optimal comparison purposes (e.g., gaps can be introduced in one or both of a first and a second amino acid or nucleic acid sequence for optimal alignment and non-homologous sequences can be disregarded for comparison purposes). In preferred embodiments, at least 30%, 40%, 50%, 60%, 70%, 80%, or 90% or more of the length of a reference sequence is aligned for comparison purposes.
The amino acid residues or nucleotides at corresponding amino acid positions or nucleotide positions are then compared. When a position in the first sequence is occupied by the same amino acid residue or nucleotide as the corresponding position in the second sequence, then the molecules are identical at that position (as used herein amino acid or nucleic acid "identity" is equivalent to amino acid or nucleic acid "homology"). The percent identity between the two sequences is a function of the number of identical positions shared by the sequences, taking into account the number of gaps, and the length of each gap, which are introduced for optimal alignment of the two sequences.
The comparison of sequences and determination of percent identity and similarity between two sequences can be accomplished using a mathematical algorithm.
(Computational Molecular Biology, Lesk, A.M., ed., Oxford University Press, New York, 1988;
Biocomputing:
Informatics and Genome Projects, Smith, D.W., ed., Academic Press, New York, 1993;
Computer Analysis ofSequence Data, Part l, Griffin, A.M., and Griffin, H.G., eds., Humana Press, New Jersey, 1994; Sequence Analysis in Molecular Biology, von Heinje, G., Academic Press, 1987; and Sequence Analysis Primer, Gribskov, M. and Devereux, J., eds., M Stockton Press, New York, 1991 ). In a preferred embodiment, the percent identity between two amino acid sequences is determined using the Needleman and Wunsch (J. Mol. Biol.
(48):444-453 (1970)) algorithm which has been incorporated into the GAP program in the GCG
software package, using either a Blossom 62 matrix or a PAM250 matrix, and a gap weight of 16, 14, 12, 10, 8, 6, or 4 and a length weight of l, 2, 3, 4, S, or 6. In yet another preferred embodiment, the percent identity between two nucleotide sequences is determined using the GAP program in the GCG software package (Devereux, J., et al., Nucleic Acids Res. 12(1):387 (1984)), using a NWSgapdna.CMP matrix and a gap weight of 40, 50, 60, 70, or 80 and a length weight of l, 2, 3, 4, 5, or 6. In another embodiment, the percent identity between two amino acid or nucleotide sequences is determined using the algorithm of E.
Myers and W.
Miller (CABIOS, 4:11-17 (1989)) which has been incorporated into the ALIGN
program (version 2.0), using a PAM120 weight residue table, a gap length penalty of 12 and a gap penalty of 4.
The nucleic acid and protein sequences of the present invention can further be used as a "query sequence" to perform a search against sequence databases to, for example, identify other viruses related to AsGV or functionally related protein sequences. Such searches can be performed using the NBLAST and XBLAST programs (version 2.0) of Altschul, et al. (J.
Mol. Biol. 215:403-10 (1990)). BLAST nucleotide searches can be performed with the NBLAST program, score = 100, wordlength = 12 to obtain nucleotide sequences homologous to the nucleic acid molecules of the invention. BLAST protein searches can be performed with the XBLAST program, score = 50, wordlength = 3 to obtain amino acid sequences homologous to the proteins of the invention. To obtain gapped alignments for comparison purposes, Gapped BLAST can be utilized as described in Altschul et al.
(Nucleic Acids Res.
25(17): 3389-3402 (1997)). When utilizing BLAST and gapped BLAST programs, the default parameters of the respective programs (e.g., XBLAST and NBLAST) can be used.
The results of one such analysis are provided in Figure 3.
Full-length pre-processed forms, as well as mature processed forms, of proteins that comprise one of the peptides of the present invention can readily be identified as having complete sequence identity to one of the AsGV peptides of the present invention as well as being encoded by the same viral gene as the AsGV peptide provided herein.
Variants of a AsGV peptide can readily be identified as being a AsGV protein having a high degree of sequence homology/identity (also referred to as "significant sequence homology') to at least a portion of the AsGV peptide as well as being encoded by the same viral gene as the AsGV peptide provided herein. Viral genes can readily be determined based on the AsGV

sequence information provided in Figure 3. As used herein, two proteins (or a region of the proteins) have significant homology when the amino acid sequences are typically at least about 70-80%, 80-90%, and more typically at least about 90-95% or more homologous. A
significantly homologous amino acid sequence, according to the present invention, will be encoded by a nucleic acid sequence that will hybridize to a AsGV peptide encoding nucleic acid molecule under stringent conditions as more fully described below.
Paralogs of a AsGV peptide can readily be identified as having some degree of significant sequence homology/identity to at least a portion of the AsGV
peptide, as being encoded by a gene from AsGV, and as having similar activity or function. Two proteins will typically be considered paralogs when the amino acid sequences typically share at least about 60% or greater, and more typically at least about 70% or greater homology through a given region or domain. Such paralogs will be encoded by a nucleic acid sequence that will hybridize to an AsGV peptide encoding nucleic acid molecule under moderate to stringent conditions as more fully described below.
Orthologs of an AsGV peptide can readily be identified as having some degree of significant sequence homology/identity to at least a portion of the AsGV
peptide as well as being encoded by a gene from another virus. Preferred orthologs will be isolated from viruses of commercial or medical importance for the development of broad-spectrum diagnostic and anti-viral agents. Such orthologs will be encoded by a nucleic acid sequence that will hybridize to a AsGV peptide encoding nucleic acid molecule under moderate to stringent conditions, as more fully described below, depending on the degree of relatedness of the two viruses yielding the proteins.
Non-naturally occurring variants of the AsGV peptides of the present invention can readily be generated using recombinant techniques. Such variants include, but are not limited to, deletions, insertions, and substitutions in the amino acid sequence of the AsGV peptide. For example, one class of substitutions is conserved amino acid substitutions.
Such substitutions are those that substitute a given amino acid in an AsGV peptide by another amino acid of like characteristics. Typically seen as conservative substitutions are the replacements, one for another, among the aliphatic amino acids Ala, Val, Leu, and Ile; interchange of the hydroxyl residues Ser and Thr; exchange of the acidic residues Asp and Glu;
substitution between the amide residues Asn and Gln; exchange of the basic residues Lys and Arg; and replacements among the aromatic residues Phe and Tyr. Guidance concerning which amino acid changes are likely to be phenotypically silent are found in Bowie et al., Science 247:1306-1310 (1990).

Variant AsGV peptides can be fully functional or can lack function in one or more activities, e.g. ability to bind to host cell receptors or ability to form structural components such as the viral nucleocapsid or outer membrane, etc. Fully fimctional variants typically contain only conservative variation or variation in non-critical residues or in non-critical regions. Figure 3 provides the results of protein analysis and can be used to identify critical domains/regions.
Functional variants can also contain substitutions of similar amino acids that result in no change or an insignificant change in function. Alternatively, such substitutions may positively or negatively affect function to some degree.
Non-functional variants typically contain one or more non-conservative amino acid substitutions, deletions, insertions, inversions, or truncation or a substitution, insertion, inversion, or deletion in a critical residue or critical region.
Amino acids that are essential for function can be identified by methods known in the art, such as site-directed mutagenesis or alanine-scanning mutagenesis (Cunningham et al., Science 244:1081-1085 (1989)), particularly using the results provided in Figure 3.
The latter procedure introduces single alanine mutations at every residue in the molecule. The resulting mutant molecules are then tested for biological activity such as DNA binding. Sites that are critical for virus/host cell receptor binding can also be determined by structural analysis such as crystallization, nuclear magnetic resonance or photoaffinity labeling (Smith et al., J. Mol. Biol.
224:899-904 (1992); de Vos et al. Science 255:306-312 (1992)).
The present invention further provides fragments of the AsGV peptides, in addition to proteins and peptides that comprise and consist of such fragments, particularly those comprising the residues identified in Figure 3. The fragments to which the invention pertains, however, are not to be construed as encompassing fi~agments that may be disclosed publicly prior to the present invention.
As used herein, a fragment comprises at least 8, 10, 12, 14, 16, or more contiguous amino acid residues from an AsGV peptide. Such fragments can be chosen based on the ability to retain one or more of the biological activities of the AsGV peptide or could be chosen for the ability to perform a function, e.g. bind a substrate or act as an immunogen.
Particularly important fragments are biologically active fragments, peptides that are, for example, about 8 or more amino acids in length. Such fragments will typically comprise a domain or motif of the AsGV peptide, e.g., active site or a substrate-binding domain. Further, possible fragments include, but are not limited to, domain or motif containing fragments, soluble peptide fragments, and fragments containing immunogenic structures. Predicted domains and functional sites are readily identifiable by computer programs well known and readily available to those of skill in the art (e.g., PROSITE analysis).
Polypeptides often contain amino acids other than the 20 amino acids commonly referred to as the 20 naturally occurring amino acids. Further, many amino acids, including the terminal amino acids, may be modified by natural processes during the course of viral infection, such as processing and other post-translational modifications by the host cell, or by chemical modification techniques well known in the art. Common modifications that occur naturally are described in basic texts, detailed monographs, and the research literature, and they are well known to those of skill in the art.
Examples of known modifications include, but are not limited to, acetylation, acylation, ADP-ribosylation, amidation, covalent attachment of flavin, covalent attachment of a heme moiety, covalent attachment of a nucleotide or nucleotide derivative, covalent attachment of a lipid or lipid derivative, covalent attachment of phosphotidylinositol, cross-linking, cyclization, disulfide bond formation, demethylation, formation of covalent crosslinks, formation of cystine, formation of pyroglutamate, formylation, gamma carboxylation, glycosylation, GPI anchor formation, hydroxylation, iodination, methylation, myristoylation, oxidation, proteolytic processing, phosphorylation, prenylation, racemization, selenoylation, sulfation, transfer-RNA
mediated addition of amino acids to proteins such as arginylation, and ubiquitination.
Such modifications are well known to those of skill in the art and have been described in great detail in the scientific literature. Several particularly common modifications, glycosylation, lipid attachment, sulfation, gamma-carboxylation of glutamic acid residues, hydroxylation and ADP-ribosylation, for instance, are described in most basic texts, such as Proteins - Structure and Molecular Properties, 2nd Ed., T.E. Creighton, W. H. Freeman and Company, New York (1993). Many detailed reviews are available on this subject, such as by Wold, F., Posttranslational Covalent Modification of Proteins, B.C. Johnson, Ed., Academic Press, New York 1-12 (1983); Seifter et al. (Meth. Enzymol. 182: 626-646 (1990)) and Rattan et al. (Ann.
N. Y. Acad. Sci. 663:48-62 ( 1992)).
Peptides or protein encoding sequences of the present invention can be modified or mutated, either naturally, such as by host cell mechanisms, or by techniques known to those of skill in the art, to disrupt protein formation or protein fimction, and thereby disrupt viral replication and function. These methods can be used to prevent and/or treat viral infection or to potentially expand the host range for insect control measures.
Accordingly, the AsGV peptides of the present invention also encompass derivatives or analogs in which a substituted amino acid residue is not one encoded by the genetic code, in which a substituent group is included, in which the mature AsGV peptide is fused with another compound, such as a compound to increase or decrease the half life of the AsGV
peptide (for example, polyethylene glycol), in which the additional amino acids are fi,~.ced to the mature AsGV peptide, such as a leader or secretory sequence or a sequence for purification of the mature AsGV peptide or a pro-protein sequence, or in which the AsGV peptide has been modified or mutated, either naturally or recombinantly, to disrupt protein fimction, and thereby disrupt AsGV fianction and/or replication.
Protein/Peptide Uses The proteins of the present invention can be used in substantial and specific assays related to the functional information provided in the figures; to raise antibodies or to elicit another immune response; as a reagent (including the labeled reagent) in assays designed to quantitatively determine levels of the protein (or its binding partner or ligand) in biological samples; and as markers for infected samples in which the corresponding protein is preferentially expressed (either constitutively or at a particular stage of viral infection). Where the protein binds or potentially binds to another protein or ligand (such as, for example, a host cell receptor protein), the protein can be used to identify the binding partner/ligand so as to develop a system to identify inhibitors of the binding interaction. Any or all of these uses are capable of being developed into reagent grade or kit format for commercialization as commercial products.
Methods for performing the uses listed above are well known to those skilled in the art. References disclosing such methods include "Molecular Cloning: A
Laboratory Manual", 2d ed., Cold Spring Harbor Laboratory Press, Sambrook, J., E. F. Fritsch and T. Maniatis eds., 1989, and "Methods in Enzymology: Guide to Molecular Cloning Techniques", Academic Press, Berger, S. L. and A. R. Kimmel eds., 1987.
The potential uses of the viral peptides of the present invention are based primarily on the function of the protein. For example, isolated AsGV peptides serve as targets for identifying insecticidal agents. Specific and substantial uses for the molecules of the present invention are provided herein. Further uses can readily be determined using the information provided herein, that which is known in the art, and routine experimentation.
The proteins of the present invention (including variants and fragments that may have been disclosed prior to the present invention) are usefi~l for biological assays for viruses that are related to AsGV. Such assays involve any of the known protein functions or activities or properties useful for diagnosis of AsGV infection, production of insecticidal agents and potentially expanding the host range of AsGV.
The proteins of the present invention are also useful in virus screening assays, in cell-based or cell-free systems. Cell-based systems can be native, i.e., host cells infected with the virus, as a biopsy or expanded in cell culture. In an alternate embodiment, cell-based assays involve recombinant host cells expressing the viral protein. Cell-based or cell-free systems can be used in assays for protein activity, such as enzymatic activity. Cell-free assays can be used to detect the ability of a compound to directly bind to a protein or nucleic acid fragment of the present invention.
The polypeptides can be used to identify compounds that modulate activity of the protein. Both the AsGV peptides of the present invention and appropriate variants and fragments can be used in high-throughput screens to assay candidate compounds for the ability to bind to the AsGV peptide. These compounds can be further screened against a functional AsGV peptide to determine the effect of the compound on the AsGV peptide activity. Further, these compounds can be tested in shrimp to determine activity/effectiveness.
Compounds can be identified that inactivate the AsGV peptide to a desired degree (antagonists).
Further, the proteins of the present invention can be used to screen a compound for the ability to stimulate or inhibit interaction between the AsGV protein and a target molecule that normally interacts with the AsGV protein, e.g. a host cell receptor. Such assays typically include the steps of combining the AsGV protein with a candidate compound under conditions that allow the AsGV pmtein, or fragment thereof, to interact with the target molecule, and detecting the formation of a complex between the AsGV protein and the target or detecting the biochemical consequence of the interaction between the AsGV protein and the target, such as any of the associated effects of host cell signal transduction such as protein phosphorylation, cAMP
turnover, or adenylate cyclase activation, etc.
Candidate compounds include, for example, l ) peptides such as soluble peptides, including Ig-tailed fusion peptides and members of random peptide libraries (see, e.g., Lam et al., Nature 354:82-84 (1991); Houghten et al., Nature 354:84-86 (1991)) and combinatorial chemistry-derived molecular libraries made of D- and/or L- configuration amino acids; 2) phosphopeptides (e.g., members of random and partially degenerate, directed phosphopeptide libraries, see, e.g., Songyang et al., Cell 72:767-778 (1993)); 3) antibodies (e.g., polyclonal, monoclonal, anti-idiotypic, chimeric, and single chain antibodies as well as Fab, F(ab')Z, Fab expression library fragments, and epitope-binding fragments of antibodies);
and 4) small organic and inorganic molecules (e.g., molecules obtained from combinatorial and natural product libraries).
One candidate compound is a non-virulent soluble fragment of the AsGV peptide that competes for substrate binding, such as for binding to shrimp cellular receptors. Other candidate compounds include non-virulent mutant AsGV peptides or appropriate fragments containing mutations that prevent AsGV virulence and thus compete for substrate.
Accordingly, a fragment that competes for substrate, for example with a higher affinity, or a fragment that binds substrate but is inactive or non-virulent, is encompassed by the present invention.
The invention further includes other end point assays to identify compounds that inhibit AsGV activity. The assays typically involve an assay of events in the insect cell signal transduction pathway that indicate viral activity. Thus, the phosphorylation of a substrate, activation of a protein, a change in the expression of genes that are up- or down-regulated in a host cell in response to AsGV infection can be assayed, and use to potentially expand the host range of AsGV.
Any of the viral functions mediated by an AsGV protein can be used as an endpoint assay. These include all of the biochemical or biological events described herein, and in the references cited herein, incorporated by reference for these endpoint assay targets, and other functions known to those of ordinary skill in the art or that can be readily identified using the information provided in the figures, particularly Figure 3.
The proteins of the present invention are also useful in competition binding assays in methods designed to discover compounds that interact with the viral protein (e.g. binding partners and/or ligands). Thus, a compound is exposed to a viral polypeptide under conditions that allow the compound to bind or to otherwise interact with the polypeptide.
Soluble viral polypeptide is also added to the mixture. If the test compound interacts with the soluble viral polypeptide, it decreases the amount of complex formed or activity from the viral protein target.
This type of assay is particularly useful in cases in which compounds are sought that interact with specific regions of the viral protein. Thus, the soluble polypeptide that competes with the target viral protein region is designed to contain peptide sequences corresponding to the region of interest. See Hodgson, Bioltechnology, 1992, Sept 10(9), 973-80, for a review of competition binding assays and other receptor screening assays.
To perform cell free drug screening assays, it is sometimes desirable to immobilize either the viral protein, or fragment, or its target molecule to facilitate separation of complexes from uncomplexed forms of one or both of the proteins, as well as to accommodate automation of the assay.

Techniques for immobilizing viral proteins on matrices can be used in the drug screening assays. In one embodiment, a fusion protein can be provided which adds a domain that allows the viral protein to be bound to a matrix. For example, glutathione-S-transferase fusion proteins can be adsorbed onto glutathione sepharose beads (Sigma Chemical, St. Louis, MO) or glutathione derivatized microtitre plates, which are then combined with the cell lysates (e.g., 35S-labeled) and a candidate drug compound, and the mixture incubated under conditions conducive to complex formation (e.g., at physiological conditions for salt and pH).
Following incubation, the beads are washed to remove any unbound label, and the matrix immobilized and radiolabel determined directly, or in the supernatant after the complexes are dissociated. Alternatively, the complexes can be dissociated from the matrix, separated by SDS-PAGE, and the level of a viral protein target ligand, such as a host cell receptor protein, found in the bead fraction quantitated from the gel using standard electrophoretic techniques. For example, either the viral protein or its target ligand can be immobilized utilizing conjugation of biotin and streptavidin using techniques well known in the art. Alternatively, antibodies reactive with the viral protein but which do not interfere with binding of the viral protein to its target ligand can be derivatized to the wells of the plate, and the viral protein trapped in the wells by antibody conjugation.
Preparations of a viral protein target ligand and a candidate compound are incubated in the viral protein-presenting wells and the amount of complex trapped in the well can be quantitated.
Methods for detecting such complexes, in addition to those described above for the GST-immobilized complexes, include immunodetection of complexes using antibodies reactive with the viral protein target ligand, or which are reactive with viral protein and compete with the target ligand, as well as enzyme-linked assays which rely on detecting an enzymatic activity associated with the target ligand.
Agents that modulate one of the viral proteins of the present invention can be identified using one or more of the above assays, alone or in combination. It is generally preferable to use a cell-based or cell free system first and then confirm activity in a shrimp, or other organism, infected with AsGV.
Modulators of viral protein activity identified according to these drug-screening assays can be used to promote infectivity with AsGV. These methods include the steps of administering a modulator of viral protein activity in a pharmaceutical composition to an organism, such as a insect, that is infected with AsGV, the modulator being identified as described herein.
In yet another aspect of the invention, the AsGV proteins can be used as "bait proteins" in a two-hybrid assay or three-hybrid assay (see, e.g., U.S. Patent No. 5,283,317;
Zervos et al. (1993) Cell 72:223-232; Madura et al. (1993) J. Biol. Chem.
268:12046-12054;

Bartel et al. (1993) Biotechnigues 14:920-924; Iwabuchi et al. (1993) Oncogene 8:1693-1696; and Brent W094/10300), to identify other proteins which bind to or interact with the viral protein and are involved in viral protein activity, and therefore are targets for inhibiting viral protein activity.
The two-hybrid system is based on the modular nature of most transcription factors, which consist of separable DNA-binding and activation domains. Briefly, the assay utilizes two different DNA constructs. In one construct, the gene that codes for a viral protein is fused to a gene encoding the DNA binding domain of a known transcription factor (e.g., GAL-4). In the other construct, a DNA sequence, from a library of DNA
sequences, that encodes an unidentified protein ("prey" or "sample") is fused to a gene that codes for the activation domain of the known transcription factor. If the "bait" and the "prey" proteins are able to interact, in vivo, forming a viral protein-dependent complex, the DNA-binding and activation domains of the transcription factor are brought into close proximity. This proximity allows transcription of a reporter gene (e.g., LacZ) which is operably linked to a transcriptional regulatory site responsive to the transcription factor.
Expression of the reporter gene can be detected and cell colonies containing the functional transcription factor can be isolated and used to obtain the cloned gene which encodes the protein which interacts with the viral protein.
This invention further pertains to novel agents identified by the above-described screening assays. Accordingly, it is within the scope of this invention to further use an agent identified as described herein in an appropriate animal model, such as a insect infected with AsGV. For example, an agent identified as described herein (e.g., a viral protein-modulating agent, an antisense viral nucleic acid molecule, a viral protein-specific antibody, or a viral protein-binding partner) can be used in a shrimp, or other organism, infected with AsGV to determine the efficacy, toxicity, or side effects of treatment with such an agent.
Alternatively, an agent identified as described herein can be used in an animal or other model to determine the mechanism of action of such an agent. Furthermore, this invention pertains to uses of novel agents identified by the above-described screening assays for enhancing the infection as described herein.
The viral proteins of the present invention are also useful for providing targets for diagnosing viral infection. Accordingly, the invention provides methods for detecting the presence, or levels of, the viral protein (or encoding nucleic acid) in an infected cell, tissue, or organism. The method involves contacting a biological sample with a compound capable of interacting with the viral protein such that the interaction can be detected.
Such an assay can be provided in a single detection format or a mufti-detection format such as an antibody chip array.
One agent for detecting a protein in a sample is an antibody capable of selectively binding to an AsGV protein. A biological sample includes tissues, cells and biological fluids isolated from a shrimp or other infected organism, as well as tissues, cells and fluids present within the infected organism.
In vitro techniques for detection of viral peptide include enzyme linked immunosorbent assays (ELISAs), Western blots, immunoprecipitations and immunofluorescence using a detection reagent, such as an antibody or protein binding agent.
Alternatively, the peptide can be detected in vivo in an infected organism by introducing into the subject a labeled anti-peptide antibody or other type of detection agent. For example, the antibody can be labeled with a radioactive marker whose presence and location in an infected organism can be detected by standard imaging techniques. Particularly usefizl are methods that detect fragments of a peptide in a sample.
Antibodies The invention also provides antibodies that selectively bind to one of the AsGV peptides of the present invention, a protein comprising such a peptide, as well as variants and fragments thereof. As used herein, an antibody selectively binds a target peptide when it binds the target peptide and does not significantly bind to unrelated proteins. An antibody is still considered to selectively bind a peptide even if it also binds to other proteins that are not substantially homologous with the target peptide so long as such proteins share homology with a fragment or domain of the peptide target of the antibody. In this case, it would be understood that antibody binding to the peptide is still selective despite some degree of cross-reactivity.
As used herein, an antibody is defined in terms consistent with that recognized within the art: they are mufti-subunit proteins produced by a mammalian organism in response to an antigen challenge. 'The antibodies of the present invention include polyclonal antibodies and monoclonal antibodies, as well as fragments of such antibodies, including, but not limited to, Fab or F(ab')2, and Fv fragments.
Many methods are known for generating and/or identifying antibodies to a given target peptide. Several such methods are described by Harlow, Antibodies, Cold Spring Harbor Press, (1989). In general, to generate antibodies, an isolated peptide is used as an immunogen and is administered to a mammalian organism, such as a rat, rabbit or mouse. The antibodies generated by the organism in response to the immunogen are then isolated. The fizll-length protein, an antigenic peptide fragment or a fixsion protein can be used. Particularly important fragments are those covering fixnctional domains, such as the domains identified in Figure 3, and domains of sequence homology or divergence between AsGV and other viruses, such as those that can readily be identified using protein alignment methods and as presented in the figures.
Monoclonal antibodies can be produced by hybridomas, which are immortalized cell lines capable of secreting a specific monoclonal antibody. The immortalized cell lines can be created in vitro by fusing two different cell types, usually lymphocytes, one of which is a tumor cell.
Antibodies are preferably prepared from regions or discrete fragments of the AsGV
proteins. Antibodies can be prepared from any region of the peptide as described herein.
However, preferred regions will include those involved in function/activity and/or virus/host interaction. Figure 3 can be used to identify particularly important regions while sequence alignment can be used to identify conserved and unique sequence fragments.
An antigenic fragment will typically comprise at least 8 contiguous amino acid residues.
The antigenic peptide can comprise, however, at least 10, 12, 14, 16 or more amino acid residues. Such fragments can be selected on a physical property, such as fragments corresponding to regions that are located on the surface of the protein, e.g., hydrophilic regions, or can be selected based on sequence uniqueness (see Figure 3).
Detection of an antibody of the present invention can be facilitated by coupling (i.e., physically linking) the antibody to a detectable substance. Examples of detectable substances include various enzymes, prosthetic groups, fluorescent materials, luminescent materials, bioluminescent materials, and radioactive materials. Examples of suitable enzymes include horseradish peroxidase, alkaline phosphatase, (3-galactosidase, or acetylcholinesterase; examples of suitable prosthetic group complexes include streptavidin/biotin and avidin/biotin; examples of suitable fluorescent materials include umbelliferone, fluorescein, fluorescein isothiocyanate, rhodamine, dichlorotriazinylamine fluorescein, dansyl chloride or phycoerythrin; an example of a luminescent material includes luminol; examples of bioluminescent materials include luciferase, luciferin, and aequorin, and examples of suitable radioactive material include l2sI, ~31I, 3sS or 3H.
Antibody Uses The antibodies can be used to isolate one of the proteins of the present invention by standard techniques, such as affinity chromatography or immunoprecipitation.
The antibodies can facilitate the purification of the natural viral protein from host cells infected with AsGV, as well as recombinantly produced protein. In addition, such antibodies are useful for detecting the presence of the viral proteins of the present invention in cells or tissues in order to determine the pattern of viral infection among various cells or tissues in a insect or other organism over the course of viral infection. Further, such antibodies can be used to detect protein in situ, in vitro, or in a cell lysate or supernatant in order to evaluate the abundance and pattern of viral infection.
The antibodies can also be used to assess subcellular localization of virus particles in host cells. The diagnostic uses can be applied, not only in genetic testing, but also in monitoring a treatment modality.
The antibodies are also useful diagnostic tools, such as for use as immunological markers for aberrant viral protein analyzed by electrophoretic mobility, isoelectric point, tryptic peptide digest, and other physical assays known tv those in the art.
The antibodies are also useful for inhibiting protein function. For example, antibodies may bind directly to viral peptides to block binding of the viral peptide to a binding partner such as a host cell receptor. Antibodies can be prepared against specific fragments containing sites required for protein function or against intact viral protein that is associated with virulence.
The invention also encompasses kits for using antibodies to detect the presence of an AsGV protein in a biological sample, such as an insect cell sample. The kit can comprise antibodies such as a labeled or labelable antibody and a compound or agent for detecting viral protein in a biological sample; means for determining the amount of protein in the sample;
means for comparing the amount of protein in the sample with a standard; and instructions for use. Such a kit can be supplied to detect a single protein or epitope or can be configured to detect one of a multitude of epitopes, such as in an antibody detection array. Arrays are described in detail above for nucleic acid arrays and similar methods have been developed for antibody arrays.
Certain aspects of the present invention are described in greater detail in the non-limiting examples that follow:
Examples:
AsGV crude extract Agrotis segetum (AS) was infected with AsGV-XJ by way of mouth. The bodies of dry infected insects were soaked in saline or O.1M PBS (pH 7.0). The tissue was homogenized, frozen and thawed 3-4 times. The suspension was then filtered by a nylon filter, and was centrifuged at 2004 rpm for 10 minutes. The supernatant from the previous centrifugation was re-centrifuged at 10,000 xg for 30 min at 4°C. The pellet was suspended in double distilled water. After several high and low speed centrifugations, the crude extract was obtained. The concentrated extracte was further purified by 10-70% (w/v) glycerol gradient centrifugation at 3,200rpm, for 40 minutes. A white band was obtained and dialyzed for 24 hours. After glycerol was removed, the extracted sample was centrifuged three times by a high-speed centrifugation. The final purified product was kept at -20°C for further DNA
extraction.
Purification of viral DNA
20 mg of purified AsGV extract was dissolved in 2.4 ml double distilled water with addition of 13 mg Na2C03 (final concentration of 50 mM, pH 10.0). The content was incubated at 37°C for 30 minutes until it turned clear. The 10 x TM
(500 mM Tris.HCL, pH

7.8, 100 mM MgCl2), 0.25m1 10% SDS, 0.1 ml, SOOmM EDTA (pH 8.0), 25 p,1, 20mg/ml proteinase K, was added to the mixture. The content was incubated at 56°C for 30 minutes.
Subsequently, the supernatant was extracted with an equal volume of a mixture of phenol:chloroform:isopropanol (25:24:1). The supernatant was collected by centrifuging at 12,000 xg for 15 minutes. Then the supernatant was further extracted with an equal volume of a mixture of chloroform:isopropanol(24:1), and collected by centrifugation at 12,000 x g for 15 minutes. Then the supernatant was precipitated by 1/2 volume of 7.5 M
NH4AC and 2.5 volume of ethanol, and was washed with 70% ethanol and dried for 30 minutes. The pellet was re-suspended in 150 p1 TE and incubated for 60 minutes at 55°C for dissolution.
The concentration of DNA was measured by running the sample on agarose gel with lamda DNA.
The nucleocapsid suspension was lysed with 2 ml of GTE buffer (6 mol/1 guanidine hydrochloride; 50 mmoUl Tris-HCI; 10 mmol/1 EDTA; pH 7.0), slightly mixed, and then centrifuged at 25,000 x g for 10 min at 4 °C. The supernatant was collected and 0.02 volume of 1 mol/1 MgCl2 and 0.6 volume of isopmpanol were added. After centrifugation, the pellet was picked out with pipette tip, washed twice with 70% ethanol and then dissolved in 1 ml of TE buffer containing 0.5% (w/v) SDS and 0.5 mg/ml proteinase K and incubated at 55°C for 2-3 hrs. The DNA was precipitated again with 0.01 volume of 1 mol/1 MgCl2 and 0.25 volume of isopropanol and dissolved in 0.1 x TE buffer. The viral DNA obtained was quantified by a spectrophotometer.
After centrifugation at 5000 x g for 10 min, the supernatant was centrifuged again at 25,000 x g for 20 min. The pellet was suspended in TESP buffer and differential centrifugation was repeated. The precipitate was resuspended in TMP (100 mmol/l, Tri's-HCI, pH 7.5, 10 mmol/1 MgClz/l, 1 mmol/1 PMSF) buffer and treated with DNase and RNase. The mixture was incubated at 37°C for 15 min and 30 ml of TESP buffer was added. Differential centrifugation was repeated again and the pellet was resuspended in 1 ml of TESP buffer, 1 ,u1 of suspension was dropped on a copper grid, negatively stained with 2% (w/v) uranyl acetate, pH 7.6, and observed using a JEM-100CX II transmission electron microscope.
AsGV genomic DNA library construction Construction of a random "shotgun" library:
AsGV genomic DNA was sheared by sonication, and the ends were blunted by Mung Bean nuclease. The DNA fragments between 0.8-2kb were recovered from an agarose gel following electrophoresis. The blunt end DNA was cloned into pUC 18 vectors.
The vector was subsequently transformed into DHSa cells and plated onto LB plates.
Construction of a restriction fragment library:
pBluescript vectors were digested by the restriction enzyme (pUClB/SmalI/BAP
(50ng/ul), Pharmacia Biotech) and the ends were dephosphorylated. The fragments were cloned into pBluescript vectors and transformed into XL-blue competent cells.
Subsequently, the DNA plasmids were prepared.
Large scale DNA sequencing PCR reactions:
PCR reactions were carned out in 25 ~I volume containing 0.2mM dNTP, l.SmM
MgClz, 5 ~M of each primer, 2.5 units of Taq polymerase, and a single white colony as the template. 1,u1 was taken out as glycerol stocks. PCR reactions were done in a thermal cycler. The cycling profile consisted of an initial denaturation at 95°C for 12 min (one cycle) followed by 30 cycles of denaturation at 95°C for 15s, annealing at 58°C for ZOs, and extension at 72°C for 2 min. Then 5 ,u1 of PCR products were visualized on 1% agarose gels stained with ethidium bromide. Excess primers and dNTPs were removed by digesting the PCR products with exonuclease I and shrimp alkaline phosphatase.
DNA sequencing:
Sequencing reactions were carried out in 5 ~tl volumes containing 1p.1 of "BigDye"
dye terminator premix (PE Applied Biosystems), 3.2~M of sequencing primer, and 30-90ng of PCR product. Sequencing reactions were done in a PE 9700. The cycling profile consisted of 30 cycles of denaturation at 95°C for 30s, annealing at 50°C
for 30s, and extension at 60°C

for 4 min. Excess dye terminators were remove by ethanol precipitation, and sequencing was carried out on an ABI 377 automated sequencer.
Sequence analysis A total of 2688 sequences were assembled in a UNIX system using InnerPeace software designed based on the "Phred," Phrap" and "Consed" programs originally developed at the University of Washington. Sequences were edited and finished as follows: a) for bad sequence quality, sequencing was repeated; b) for regions with repetitive sequences, which may cause misassembly, primers were designed for walking on the original PCR
products or on plasmid DNA; c) for mapping gaps, clones were sequenced that cover the gap;
d) for physical gaps, PCR primers were designed between the gaps, then the PCR
products were sequenced that cover the gap; andlor e) for gaps that can't be covered by PCR
methods, walking on AsGV genomic DNA was applied.
AsGV cDNA library construction and AsGV cDNA clone selection Agrotis segetum, a cutworm, belongs to Noctuidae and Lepidoptera. It was captured at nighttime at around 22:00-24:00 by Buglight. The captured bug is at its adult stage and the adult butterfly was fed with 20% honey. After the eggs were hatched at 26°C, the Chenomm amaranticolor leaf was used to feed the insect. The Chenomm amaranticolor leaves were cleaned and sterilized under UV light. The leaves were further treated with a solution comprising 20mg of AsGV-XJ in 5 ml of sterile water. The young Agrotis segetum was starved for 24 hours and subsequently was fed with treated dry leaves. The samples of the infected insects were collected at 12 hours, 24 hours, 36 hours, 48 hours and 96 hours after feeding. Finally, these samples were stored in liquid nitrogen.
The infected young insects were cleaned and homogenized. The RNA from the infected young insects was extracted by using GIBCO BRL RNA extraction kit.
Poly(A)-mRNA was purified by using the "PolyATtract System1000" kit (Promega). Double stranded cDNA was synthesized and cloned using the "SUPERSCRIPTS Plasmid System for cDNA
Synthesis and Plasmid Cloning" kit (GIBCO BRL). AsGV cDNA clones were selected by DNA hybridization using Dig-labeled AsGV genomic DNA as a probe (Dig labeling kit, Boehringer Mannheim). Finally, the plasmid DNA was prepared for automatic sequencing.
All publications and patents mentioned in the above specification are herein incorporated by reference. Various modifications and variations of the described method and system of the invention will be apparent to those skilled in the art without departing from the scope and spirit of the invention. Although the invention has been described in connection with specific preferred embodiments, it should be understood that the invention as claimed should not be unduly limited to such specific embodiments. Indeed, various modifications of the above-described modes for carrying out the invention, which are obvious to those skilled in the field of molecular biology or related fields, are intended to be within the scope of the following claim.

1308 SEQ.LISTING.txt SEQUENCE LISTING
<110> Xin Jiang Westar BioEngineering Company, Ltd., et al.
<120> PRIMARY NUCLEOTIDE SEQUENCE OF THE
AGROTIS SEGETUM GRANULOSIS VIRUS (AsGV), INSECTICIDE
DISCOVERY SYSTEMS CONTAINING THIS SEQUENCE AND PREVENTION
AND CONTROLLING KITS FOR AGROTIS SEGETUM INSECT OUTBREAK AND
SPREAD
<130> CL001308 <140> TBA
<141> 2001-10-17 <150> CN01112663.9 <151> 2001-04-18 <160> 217 <170> FastSEQ for Windows Version 4.0 <210> 1 <211> 131616 <212> DNA
<213> AsGV
<400> 1 actttaaaca atattcgggt ttcaacgcca agtttgagaa gatatttcga agggaattag 60 ctggtgtaaa aaacgccgtc ctgtcgatca acaatgtggg cgacggttgc ggccacactt 120 attgcaagag gaccaaaaag attttaattt ctgcacattc tttatgggaa ccgaaacaat 180 gcactacgaa ggaggtgttt ttacatttaa gctgcgagga gtgtaaaaat gagaagagtg 240 caaaagtttt gcggcttttt attaaacctt gtctcgttcg tatgaccgaa gagtctaaat 300 tttattgtct ttgtggaaag cgattgttta ttgaaaaata aaagtttttg cactgataca 360 tttttttatt ttataaccta cctaaaaacg gaagaacaat ggtggggtcg atggaggtgt 420 gggtggtgga gaaggagtag gtgggggagt aggttcagga gtaggtgggg gagtaggttc 480 aggagtaggt gctggagtag gttcaggagt aggtggagga gtaggttcag gagtaggtgg 540 aggagtaggt tcaggagtag gtggaggagt aggttcagga gtaggtgggg gagtaggttc 600 aggagtaggt gggggagtag gttcaggagt aggtggggga gtaggttcag gagtaggtgg 660 gggagtaggt tcaggagtag gtgggggagt aggttcagga gtaggtgggg gggtaggaaa 720 aatgggtaaa atgctaggca tatcaggtat taaatgtaat tttgcgtttt taactaacaa 780 atatgtgtct tgttgaaagt ctacaggttc tcgtacattt tccttgtaaa gtaacaaacg 840 gcctggttcg cgatgaaata tttgaaccac gctaccgtca cacaaaggaa atgataaaaa 900 cgcgtcagtc atctcatgac tgcctctaaa cagctttttg taaataattt gtcccagggg 960 attcttaatt tgcattccga aatatatttg atgaaaaaag acatgtattg catcaaaatg 1020 tttataatag ttgataatac acctgtttag taaagcgtta tatttaatat ctgcaatgac 1080 atgattgtat atcgttaggg cttctaaatg atattctgtg ctgtcgcgca acgagttggg 1140 1308 SEQ.LISTING.txt taagtatttt attaaactat ctttatattc attatcttta agcttgtccc agcaaaggta 1200 aatcgattcg cgtaattttg aatcgtattt aagcatcttg ggacgattgt ctagccaggc 1260 cgtgagttta tctattcgtt tcattaaacg ctgcagttta gatggataat gaagcgcgtt 1320 ttgttcggga tatatatcgt cctctaacaa aacataagta aatgttgtgc tgttttgtat 1380 acgggtctct aaaaagtaca taatttgtaa agtattgttt cctgtggcga gattgttgta 1440 ggtaagctct aatcgatcat tgatgttgta ctttaaaacg tattcttctt gtagattaat 1500 gttagcattg attccattca aaacaaaact ctcctcttgc attgtaacaa cattgtgtaa 1560 acgtagtcta aatagtattg aattgggaaa cgaaggaaca ggatttgcat cgaacacttg 1620 tatcgatatc gttctatctt tatagttaat atgtatagtg gccgcgtaaa cgttagcctc 1680 tcctaatacg tggcccgttt caatttctaa ttcggaatac acgtacggtc gtagataata 1740 ttgtacagcg tcgacgttct ggacgtcggt tgctttaatt gttgtatctg ttactattct 1800 cgtgttatca ggaacataat atctaaggtt acctcgcgga tgtacaatgt gaaaaagacc 1860 tctgtttaca gacatctcaa aatataaagt cccactaaga cgaattatac actcttcaac 1920 cacagtatca ccgttcatta taatgattgt tttaccaact aagtcgttat taaatatatg 1980 tgtaccactg accgctctaa tataaaatgt ggcgaaccgt tattataggg taaaacgtcc 2040 gttggggtaa ccaaagcgaa ctgggtgtcg taatatgttt taattaaatg gtctgaaaag 2100 ctttcggagc tcattattgt aatttcactg tttagactat tcaagcattg tttattccga 2160 gccaaccctt catactgatg atagtagggt ttaaaagtta tattgtcagc gttggtgtaa 2220 tgcatgtaat agtcagtaat gggaacttgt aatatcattt tgaaataata ataaagatca 2280 taatgcgagt agtttcgcag aagcaaagag aagatttgac cgctctcaaa taccattcca 2340 atctgctttc gtctaaatga gcgatttaac tctctaaacc catcttctcc gtgttttgta 2400 tttaaaatta gagataaaat taaaagcttt ctaaactctg gccaagcggg aaaaggagtt 2460 ctggccgaga acaatatatt gatatcagta ataatttgtg aatacatttg tggtccaaag 2520 accgtgtttg ttagataacg ttccattttg gtagatctaa aaaattgata tctatcggca 2580 aatatgctcg cccacgtctc ttcaaatatt gatttgctat tagcaaactc aaaatcgtag 2640 gcgtgaccca tcacatgaag cattatccaa tttgaaatgg agacattgta gaaaagatcg 2700 aaagattgcg tggtcacacc aatccaaaac ggtccataat aagcagctcc ggacccgctg 2760 agatcttgtt taaaaaacat ttgcttatca aagtttgcgt caacatcagc caacgctata 2820 ccgtccttaa gaccgattag gttgtcgtag attgatattg cattattata aaaatcgtat 2880 atgttgttta aaaaatcact attcccattt ataaaagcta atctcgcaga aggtggaact 2940 aaaacaacaa tttttccaaa ttgtacgaac gcataagggg tgtcgtaagt aaaaaagcct 3000 tgtacgttat ttgagaaaac atagtttatt tgaggtaata ccgtatgttc accagttatt 3060 gtgaattcta tagtaacagc gtgtctgtat aaaacccagt caacaaaagg gacacattgg 3120 tgttgaacaa tatattcgtt ttcagtaaac gaattaatgg taagagatgt ttcggttttg 3180 ctatcattat tgagaaacct tagagtgacc gggctaccgt gtcccgtatc aattgagctg 3240 cttaatttgt aactgatttt tgtgtttggc tgtaagatat aaccaagagg agatttttta 3300 tgtaaacaag ctaaataact tttaccttct ttaatccaag cgggtaagtt taagcggggt 3360 acgataaaat tagaggaggt gcgttgaatc gacattttca cttataagta aaaactatgt 3420 taacaaaaac agtagcaaaa tataataaag actgcagtag aaaggatgcg gaatatttga 3480 atagtaacag agagatttta aaaatgtctt actacgttca agatcaactc aagaaaatga 3540 atgaaaatgt tatggttgaa cagcggcaaa atcaggcatg gttaaacgaa attgactatt 3600 gcggtacaaa agtaaatgat ttgaacgagc aaaaaacgct tcctaacact ttaaaagata 3660 tacctctctc ttctgtaatt atcaactttt gataaacttg atgccgacat ggcccgtttg 3720 gaaactttta aaagattttt tgagcccctg tcgacattaa cgcgttcaca aagtttgttg 3780 ttcaagagaa atatttaaaa gtcgtacgtg ttcgtgtgtt gttcaagaga agaaaataag 3840 tattttttga acatacgatg agaggtatct gtatattaaa aggtgacgtt agtggtacat 3900 tactttttat acaagacaag gtccaagacc gtgttaagat caccggtgtt ttgcataaac 3960 tacctcgcgg taatcacggt atacatatac acgagtttgg agacgtctca aacggttgca 4020 1308 SEQ.LISTING.txt ctttgctggt gaacatttta atccgcacca caaacaacac ggcggtccaa agagttcaga 4080 aaggcatctc ggcgatttgg gtaatatata ttcggacggc tcagcaacaa ccaaagtttc 4140 aatgtacgac aatcttataa gtttgtacgg tatgcacagt atactaggaa ggagtgtagt 4200 aatacacgct atggaagacg atttaggtgc tggtgaaaac gaattaagta aaataactgg 4260 aaactctggt agtcgcctct gttgcggtat aataggggtt aagaaacaac caattgtaac 4320 attttaaaac ctttttcttt aatataccat caccgttaat acaatatata taaaaaaatt 4380 aaacagtata ataaattcta agtttggatt caattttggt acgacacatt atacaatttt 4440 tgaaacttat agcacaatcg gcacacgtag aaatatgacc acaaggaacg aatgcgatga 4500 cagcctcttc ggtacaacaa atggcgcact tgttttttcc ctcttcctta atttttgttt 4560 ccactatcgg aaaacgctcg ttctctttaa tactgcaagc ttcggtcatt actttttgaa 4620 tgtagtccgt acctttcttg ccgattaaaa acagacactt atcaaaccag cgcgcgtgct 4680 gttgccaagg atcgtctcca gtcttccaat ctcttaaacc ccctccgcaa taaaagcaat 4740 tcacttgatc tgaatggcct gtgtaataaa atccagccgc tgccaattct ttaggacgca 4800 acggtatact aacaggccaa gttttatagc tttctaagcg attttccaag ttttcgtaaa 4860 tttttttgaa cggcgcataa gaagagaggg aagaatcgtt caaatggctc cgaacaaagt 4920 tacactgcgg tgcccatcgt ttgtgttgct caaaagcatt tatatcctct ggcactaagt 4980 tagtttccat cttgcaaaac ggacaagcga ccaaaaagtt ggaaccttta caatagaatc 5040 cactctgtga aacttcatct ttcgaaatgt ttgggtggtt ccagttagaa aaagttttaa 5100 gtcgattgtt cacatctctc attcgtaaaa attcatcctc aaaaaaactc tgttcttctt 5160 cagcgttgtg tgaaagtgta gaaaacatat ttctctcttc ttcaacaata taactcgtat 5220 gaacaccgtt cctttgagtg tgatattaaa atattatatt gcaatatatt taagaatata 5280 tatacagctg ttatctcaaa aatattttgt ttttatcttc gattatgggt ttatcgtatc 5340 acttgttatc actataatta atcgtcttgt ttttttaatc gattaacctc gttaacgtta 5400 tcattgcaca atataatgaa atatttggtg tacgtgacta gcagaacgtt tttgtaaatc 5460 taatctacaa atcggatttg tgttatcatt aatgaaagaa ccgtgtcagg aaagcttact 5520 tacaaagagt cacgtttatg ctatcgtgag ggaatgtgtc aactttaaaa aacacaactt 5580 cgatactgag aatgtactag cgcacgtgga ggattcaaac ttttcggtaa tttccgagtt 5640 tattaacgca aacgctgaca gaattttcat cagacagccc cagctcgaca ttccaataac 5700 tcctcaccga gaacgtttaa gctatatttt taatttaccg aaaaatttag agttggaata 5760 tttatattgc gaacaaaggt attacggaag caaaaatgga aattgctcct gaaataatgt 5820 cttcgatgga gagcctgaac gaggacgcta aaaactacac tgttaacgtg aagaggttta 5880 ctaatggagc agaaattgtg gatatgatgg agagcgcttc cctaaaccag ttattgaaca 5940 gcaaacgtat gaacgttatg cttaaagtgg aagttttgcc gcttaaaaag attggaccta 6000 aaaagaagaa acaacctgta ccttacacca ttaaccattt atattttata cttcattttt 6060 gagcaaggcg ggaattaaac tgaagaagga tagtaagtct tggcaatgta tgggtttaaa 6120 tccgaacaca aaggagccga ttgacttgga cgggcacaat tttagaaaat taattgcaaa 6180 acttgaagcg tttcacaaga agctgtttgt gttcgacgac ccgcccacaa ataaggtgtt 6240 aaatgtagag aagaccgatt atgttcgtaa acgagcaatt gcctatagtc aaaatttgct 6300 ggccgcatgc tataataacg agcccgttga acaaccacaa gacgacaatt cgaaagagat 6360 ctacaaatat ttggatgtgt ttaagaccac tgttgaaaag tttaaatctt ttctagtaac 6420 gcacaaattt ttaaaatccg acgaagagga cgaggatgaa gaagaggaag aagaggtgcc 6480 ggaatattct gaagacgacg aaagatcatt taagaaagcg tctcgcgtaa caaaaggttc 6540 aaaaacaaaa aatgttaaca acaccaagtt gacttttgaa atggtgaacg atatgattga 6600 taacgaatta ataggatgat tttttaaata aaaagtttat ttaaacatgt tgtgttgtta 6660 tttgataata atgaacactt tgatgcatac atgcgtcaag gtgttggtag agaataaaac 6720 taaaaaatta ccaatttatt atttacattc tctagtgtca tcacttaatg gtttaccatt 6780 gacgctgaag cgtttactac gagaacattt acctctatat tatatcgatg atacgctttt 6840 gagtatcgag cgggcggacc gatgccggga atgtagagct gccgctccac cgtattttaa 6900 1308 SEQ.LISTING.txt tcgattacct cagctgtttt gtgttaaatg tattgaaccg ctcttttcac ttaggaaaga 6960 ttcttctatt gagtatataa atagtgtgtg ccgaatatac aaatacacta cgatggagac 7020 tcaaatctac tttgcttttg ctttttcttg aatgataagc attttgcgca cttcttccat 7080 tcgcctcttg tgtatttgtt ccgccgtttc tttgactttt tctttttgct gtaataaagc 7140 ctcttgctgt tttatgactt gtacatcctt ctttttttct attttagttt cgtcgatagt 7200 catatttacg gtaacataag aataagcgag cacacacact acaataatta aagtagcgct 7260 tatcacaaac actacaacat atcgtatcaa gactctattg ttagccacta gggcgtctaa 7320 ttgatctaaa ttttccatgg taaccttagg ttacagaaaa taattatata ttggtgtgtg 7380 aagaaacaca tttcgagtgc caagaatttg gtagagacgc tccgatggtg gttttaaagt 7440 gtgatgtgta aaaggttttg ggttgcgagt gggtaggtta atggggaccg gtcctgcgtt 7500 tgttatagca accccttcat gtttacaata caaacgaacg tgtttgttct ttccacctat 7560 caagttaagc tgaataaaga catctggtac taatttgtaa cgtaaaatta gaggattgaa 7620 cacatccaaa agtttatgaa cagagcttat gtccgtgtta tcgataccta gaagctcgag 7680 cgcgtctagg acgtattggt aacttttttt gttaagcacc gtacaatttg aggacagccc 7740 gccccttaaa acacgtctag tactttccca cgaaagctct ttgtgcactg tggcaagctc 7800 ttgattggtc agatagacag agaaacgagc tctcgttttg cgcgcactta acaatataag 7860 aaatcttttg gtgtttaaaa ttttaattcc catgggtgtt tctttgcgaa aacaaattac 7920 aaagtcgtcc aggttttcgt ctctggcttt tgccatttct tgtgagtctc cagctaactc 7980 gcccacaagg atcgtgtgag catttgaatg attatacctt aagcctactt gcagagggca 8040 ccgcaatctt ctggtaatac attatgaata gtaattgagt tgcagccgaa aagattgtcg 8100 ctaagcacca cgttataaac attggtttta ccaactccga gttttgtaat gttgctaata 8160 gcgttccaat aaaccaccac acctacagct tcttgttcgt ccggttcaaa acggggtacg 8220 tgcttcaata ctcgtactgt tgtaaacccc ctaatgttga gagcttcggt attgataacc 8280 ttctcgtctt caaatgtggg cacaaatatt gtaaggtcgg tgataacagc cccgcccgcg 8340 tctcgttgtg tttcgataac gtcgtaagga aagtctacaa acaaatcgct gatatatact 8400 ataatttgat ttgaacaagc catcttgtat gttaatctta ctatggtaca taagtataaa 8460 tagttaaaca tttgataata tcacatcact ctttcttcga tcaagacacg atgcagattt 8520 ttgtgaaaac tctcaccggt aaaaccataa cagtcgagac ggagtctacc gataccatag 8580 cgtctatcaa gcagaaaatt atggacaagg aaagtgtgcc ggtggatcag cagcgtttaa 8640 tttacggcgg taagcagctg gaggacgagc gacaattggc tgattacaac attcaaaagg 8700 agagcacact tcatttagtg ttaaggttgc gcggaggttt tgactgtctt tgtaccgaag 8760 aaggtgtttg tataatgata cgatctaaca gcggagggca ctaataggcg gataagtcaa 8820 tgacgtattt tacaagaggt tctggtatgt atttgtattg gtatgtgaga agtcttacgc 8880 gttgtccttc gttaagtttc aaataaaaca aaagtagtat acaaataatg aaaagtataa 8940 ataggaaaac cattggtgta aataagttga acaatggaaa cggtggacgt gaaagagttt 9000 acaaaacaac taatcgctga tcgatgcagt atgctgatcg agagtgaaaa tatgctgccc 9060 gaaaatgtat tatcgataat aaagcgcgcc cacaaagagt ataaagaggt gccgaacgaa 9120 cgcaacttca acaatattaa agaacttatt tcacaaacaa agtatataga ggagagtgtg 9180 gaatataaga actttaatag agggattttt ttaattgcta tgaatcttat tgttagcaaa 9240 tgtcaagacg tttttccaca ctacaagcct ttcttcgcta acgcctcaaa gaggttggag 9300 aaaattaatc cggacatgaa gtcttctcca aaggcaatgc tgcagcacta ccatcaatgc 9360 atagaagaga tggagcatcc aaaacccgac gaccattaca tgatctcgtt cgctaaagag 9420 attgtaacaa aaatttttta tgatgccgta gcggacatga caaacatggg aggaagtgct 9480 gtagttatag cgcctgcgtc ttccaaagaa ttggtgttga ccaaaacgat cgagaataac 9540 agcaacaaga aaaaactagt atctttaaaa agtttaaatg aaaaaacgag caaaaaaggc 9600 tttactgttc gacctgtctg cgtgtttaat tgataataaa aagcaaatta taattatttt 9660 gcagttttaa taatacttcc taacccttct tcctcccctt cctccgatac ttttgatttt 9720 ttcttcgtct tttttggttt cggaacgggc gctggtttgc tagcggactt tctcttcctt 9780 1308 SEQ.LISTING.txt tttcctgttg caaaataatc ttctattttt tgcttcgtgg aagaagtttt agtgacaggc 9840 gatttggcac gcattatatt ttcttgataa tcataagcct ctatttcttc ttgtaaactt 9900 ggtactttgt tctgttcggg gacatcaaaa ggattttctg aaacgttctg aggaatcata 9960 actctattaa acgcttttgt gatgttgggc gctatgtcgg gcttttgtaa aggacgtgac 1002 gaaacgcttg gaacggttga aggtcccggc gtgaccacac actgtcttct tgtcgattga 1008 ttgtagtatt atttatagct cgcaaaagtt ttgttctttc tgaaatgtcc ttaaaaatgt 1014 ctggattggg aacgtttaac ctatctgaga caagtttagc gtaagcgttg tttatctgct 1020 gtgtaaagag taataaattt gttgcgttag tatttaaatt atctgtaata ctatcaacaa 1026 actgtgggta aattttcctt tgtaaagaca cattttctac taactcgggc tgtatactca 1032 aagcttcaac acacgaaacc attaaccgtt ttactggtaa aaataaagag ctatcttcac 1038 cgagttctgt gtgattaaga tcatatgtcg cctttaatgc gtttagtctg ttttcatact 1044 cgtcgatact ttcttgaaaa tcttttctaa cttcctccag tcgttttttg ctatttgcct 1050 ccatcgtatt tctagtttca gccacaacgt catctacttg tctctctaat tgtttattgg 1056 cttctttcaa tgcggcgatt tgtgtattta aagaagtaat aatatccgcg tttatttgac 1062 tgtcgcgcaa caattgtctc accttattcg attgatcatc gttaccgcta ccaccaccac 1068 cttctgtcgt cgcgacctct tcttcgtcgt taattttttg tcgttgcttc agctgttcgt 1074 tttcggtttg taattgtgat attgcttttc tagcctgtgt tattaacgtt aaacattttt 1080 cgtgtttttc ttccaattcc gccttgtctt gtattagctg ctctttttcg gttgtgagag 1086 cttcaatttc gttgtcatgc tgtttgtata atcttgcggt gtcttccatt tttctactac 1092 taaatctaag ctcttctcta cagtcgttta attgttgaat ataatcttgt aaactttttt 1098 gcaattcatc tattctctct tttgcttgac taatagctct ttcgtgtttt tctaattctt 1104 gttggcgcaa ctcttccgtt tctctacatc ttctttctaa cacaaatcta tcagcattat 1110 tagggacgtc acgctgttca tcataagagt ttgattcatc gagagcagtg tttcttaatc 1116 gaccttctaa ctcatttcta cgaatttgct cttggtccaa ttgatttgtg caatctgcga 1122 gtaactcgtc tttgtagcga ttttttactt catactcttc aagtctgtcc cgtaaagtaa 1128 tgacaagatc cgattgtgct tgaagttcgt tttgtaaata aatgttgtta gcttcgcatt 1134 1308 SEQ.LISTING.txt tttctaaggc atctctacac tgttcaagag aataatccgc ttcactcaaa cgagtctgca 1140 tgtctctaag ttccctctgt aatctcgaat agtttctctt caattcttta ttctcatcta 1146 tcagcaactg tgtcgactca tacggctctc cttgcgccct aaatcgatca tcgtcgggcg 1152 ggggtggtga aggtggcggt ctaggtggtg atgattgtga ctcttgtccg ccgctcaaaa 1158 gagtatagtt tcgtatcatg caatcgttaa gttttttctt gcatcgtttt aattcgttta 1164 atagatctgc attttctaga tctgtacgcc tatggtagtt tgtagaaatt atagacgctt 1170 caacggttgc ggggtccgct cttcggtcgc attcaacgag agctctagcc atttgtaaaa 1176 tatactctcg cacacttttg ggttggctgt aatttggttt tgtcgaaagt agctttctta 1182 actccggttt aatttgagaa gcatcatcac catcattacc attacctcct cctcttccaa 1188 gacctccgcg acctcttcct cctcgtcgag cattaaataa actttcacgt tcattaggaa 1194 aaagagttat atagtccaca ttgatgctgg tagttttctt tccgccggct tgatggacta 1200 ttctttcctc tgttaatttt tttaaaacac gtattagtag ctcttctgtg tctaaactgt 1206 tgacgttagt gtgttttcta atcctccgtt aacaattaaa aggttgcgaa ttcttttctc 1212 tttatccgta caaatgttac gctctcttac ccaattgacg accgcacggt tcatctttgc 1218 ttatatacat aagtatgata gagaaagtga acattataga aaaatctttt attaaatggt 1224 ttgtagaatt gaaagagcaa caaccatctt ttgaaaaaat atcggaagaa ttattcgaag 1230 tggtaatgga gtttctcttt atgaaacggt gtaagtatca aaaaattgaa acgtggaaca 1236 gagcgctctt ggggtgtcgc gacgattagc ttcttatcgc agtcgtcatt accgatacgg 1242 aatctttata aaagttttga cggacaccgt tggcatcaaa ttgaagagtg tgtgtcgtgt 1248 tggcaacatg tctacttcga gtcttttaga agaaataatt atttttttgg agtctgacga 1254 accgattgaa gaatttcatc aaacgctgaa gaggaaacga gaagagacta atgaaatttc 1260 ggaggtgtta tataaaaaaa tgaagaagga aagggaagag aagcaaaaag taaatttaaa 1266 cagaaaaaag aaagttaaag tagaaccgtt ggaatatgaa tgcgacgatt tgaatttgta 1272 ttatttgcgt aaatgtttgg aggaagaaaa cgaaatgtaa taaacattaa tatttaatat 1278 1308 SEQ.LISTING.txt gtggtattat ttaagcacca taacctgtcc aattgattct agtttttgta tcggtccata 1284 aacgaaaagt gggctcttcc attccatttt gactcaaacc tcgagttcct ctcaataaaa 1290 atgtgtaagc aaagtcggtg ttggaattaa aaatttccgg aggacacaat ggtttgtcgg 1296 gggagtaaag tgtaatgggg gtgtctaacg acatacattc gactctaaat tgtgatatgt 1302 tattttcaaa attgtgagtt tgttcttggg tggccgtaat gtcaactatt gaagcgcatt 1308 tcgatgtagg attaaaatca aggttcctga cgcgggtcct ttcgtaatct ccacaatcac 1314 acaagccgaa ttcaaaatcg ggatgcacgt ctctgtgaat atatctaacg tcactacaaa 1320 cgttgggtaa acactctatg ggatttaacg gattgttaaa tgtttgatta taattgacat 1326 caagcgcgtt acattttact tcaaatcttc gtcttccatc ctgcatcaaa tcgtcccaag 1332 tgcgtctaaa gttgttaaca aacggattaa caattcgatt tagctcgtta tcccacaatg 1338 ttaaatgttc gatttgatag gagggtatca tattaatgtg ttgtctacca gcttgttgta 1344 ttgaattgtt tgcacctgca aagaagcgtg gatcttctgc aatgcaagac cactggttgg 1350 cactttgtaa tattaaagat gtctgggcgt tacaacgacg cggaagagag tttgtagtac 1356 aataacctcc gctaataagc atttgtccgt ctacgacgta tcgatcgtga ggttcgacaa 1362 aaaagtaaac cgctctctcg ttgtcgcaaa tttctgcaca attatagtta tctattttat 1368 ccaccgttac caaagttggg gtgttaaaac atttattcga accttccaat gtattaaagt 1374 ttgtgtccca ctttacatta ggaagggtat gtagaggcgc gtatcttctt cgtctcaccg 1380 tttctctcaa atcctcatcg tttagtatct cttcgcgaaa gaaagcgtgt tgtctgatgg 1386 catgatggcc tagttgaagc ggtcgatata gcaaatacaa taacgcaatt atgatcgctg 1392 caaacaaagg ccaccacatg acgtcttact agaatttaat aatcatggtg gtcataatca 1398 ctattgtcgt gatggtgttt gttgtgattg tgatatttgt ttaggaagtc atcatacttg 1404 tttacgaaat gaaacaacaa agggttcgtg tgaggataaa gtggcagtag ttttttatcg 1410 ggggcgagaa gtagtcttca tgtaaagcat gaaaatgcat tttgattata tcttattata 1416 tttataaaac caccaccaaa tgtactcatc cataaatttt atgtcgccac accaaggctt 1422 1308 SEQ.LISTING.txt tttctctccg taataattga taacatacgg ttggcttctt ttaataatca tataatcacc 1428 cgcgttccac aaatacattg gagacagctg cgtcggtatg attttcaagg ctatcatggc 1434 ctgagctaag acgacttcct caaatccatt attgtatttg ttttgtaata aacacctgtt 1440 gtttggtgtt agtaaagctt ttatttgttg aaataattta acgcaaggtg cgtaaacgaa 1446 cgtgccggta aaacctaaaa cggtgctgtt gtcgaatatt tcctttaagc aaactatttg 1452 ttttccatac ttgtattttt taaaggtttc attgtaatta tgattaaagc acattgctgg 1458 tgtgatcaaa ttaaacaggt gatcaatatt tttaagcact atttgatcag cgtcaagata 1464 tacacacttt gaatactgtg taagttccaa acaacgccat ttggtgaaag aataatctat 1470 ccaggacgaa tacaattcct cttgtctcga ggttaacata ttgccgcatt tgtaatgaat 1476 aaattctact tgtatgactt tatcgaacac ccgctccaat tctgctatca atgtaacgtc 1482 tttggtcacg aggcaaaccc tatcatgata agaaccggag ctagataaac tgttagccaa 1488 ggctactgca ccaggtacat atttatcacc gagcatgatt aaagtcacgt aggcgcattt 1494 catgatctta ttaatttctg atattaaaac gccgaactat gtttatgtgg attaccgttt 1500 gttggaccgt ttaaaataca atgtaacgag agataatgtt cataattatg aacttttgtt 1506 tttttgtatg cctaattacc gtaagttgtg gtttaaacat agaaaatggc ggtccagttt 1512 taaaaaataa caccgattta tatcatactt tgtacgagag acgagttagg gctcaattac 1518 cctccaaagt agcggacgga cgaaatgcat tttaccccct cgtgttggac acaaaaaaac 1524 gcgttaaacg ctttcatgta aatcaaaatg tattttggaa cacgaacaat ataacatgga 1530 gcctttttac cgacattata cccgcaaatt taactagaaa tcaaatttca caagagatca 1536 atgatgcttt catgatttgg caaaaaacaa cgtcttggca gaaaaatgaa actatcttgt 1542 attttaccca attgttggac aatacggaga gcgcaaatat taaagtgtcg tttaggcgac 1548 gtgatcacgg cgatgggtat agttttgatg gtagaggtaa cattttagcg cacgcattcc 1554 ctccgcctat aggcaattta catttggacg ccgacgaatt gtggttgttg accaacgacg 1560 atcctttgaa ggaaggtaca tttctactac ccgtggtcgc gcacgaaata gggcatacat 1566 1308 SEQ.LISTING.txt taggtctaca gcatagtagt gtaaaaagag caatgatgta tgcttggtat cgaggtgatg 1572 ttactaaact tgatacagac gacgaaaatg gcctagaaca actgtatgtt agtaatccgt 1578 atagaaccac aacattgaaa ccgacttcaa ccacacttaa agctaccgat aagaaaaatt 1584 tgttttctcc attaccagaa tgggttacca ccgacttgta ttccaactct cttgatctaa 1590 tatgtcttga accctttaaa tctgtcgcat acttgaggca agagtattat gtgtttagga 1596 aaaatttctt ttggcgattt aatcacgcta atatgagcaa caacaacatt atagatagct 1602 atattgccgt gggaaggaaa tggtacgagg tgtgttctgt tgatgcggct ttcgagttgg 1608 atcacaatat aggttgttta gtaaaggtgt gtggtatgaa tactttaacg atatattagt 1614 aaatgtagga actgtgaaaa gtatgtttgg aaaaattggt ggtattcaaa aagtggtggg 1620 ggcgttccag gaagaggatc gtttttattt agttggtaaa aaatatgttt atacagtgaa 1626 taagaaagag aaaaaggtga taaataaaat gtttttaagc gacaaattta gaggggtggg 1632 tgaaagaatc gattggatag agagtgatag aagggttgtt cgtcgagttg gtgtaggttg 1638 gggtgtgtgg aaggtaaaag tgttaaagta taatgtcaac gtaggctata tttatgaagt 1644 tgagggtgaa attgaaaaat tgctggataa cacgtgctaa tagtgtaaaa attgcagaat 1650 aaagtgcggc gctacactat attctcatta taaactttaa aaatggatcc aagcggtcgt 1656 atggaatttg aggtgcaaaa attgaataaa gacgtggaga tttacaaaat tgcaattgaa 1662 caattgctaa caagccgcaa acaagaacga gagcagactc aaaggctaag cgaagaaatc 1668 gacagtttgg ttgcacaaaa aaatcaatgg cagcaattgg aaaaacaata taacgaagtt 1674 ataacatctt ttgctgagca attaaaaaag acagacaatg aaaatcaaga gttgacaaaa 1680 gacgttaaac gtttaaactc ttgtttggag cagcatttaa aaaccgttaa acgtctaaag 1686 aaaagaacaa aatgtctgaa gcggcttcaa aggcatgttc gtgaaaccaa tagtgttttg 1692 gatgacgtca ttcaaaacgg agattgtata ttgtctgaaa cggagagttg acaagtgagt 1698 gacatataaa cagtttgtgt atcttaactt aatcatttcc agttaaaatg ttgcataaga 1704 aggagtgttg gcagtataat ttggaatacg gtagttacac tttaagtgta ccgatagaga 171C

1308 SEQ.LISTING.txt agtttgaaac gtttgaagaa acgtatatcg tatattcaat gcagctggaa gagaccgacg 1716 attttatttt agatttgtac gatttaattg tagattacaa caaactggac aaactgttaa 1722 atctggataa agacgactgc ataatgttgt gacttgaaat aaaacaaaat atttacaaga 1728 atacattttt attttttata aaccacaaat gtatgttatt accttaacca gtttctcata 1734 gttttgaagc ttaaacctcc aattgtaact gcaatcatga gtcccagtgt aacataaaat 1740 ggtgtgacat acaactgtgc aacggtttga tataattgta caaatggaat cgagacgaat 1746 tgatcagcgg tgagcagcac aaaaccgacc aatcgttttt cttcaaattt ttggtacatt 1752 aattgttgca taatttgata cgctaaaggg ccaggagtgg acaggagtgc agataaacac 1758 caaacattga atctgttcag gtcccacgca ataatttgac atactctggc agctgtgcta 1764 aacagcatag aaatgataaa agctatcatt gtaactgcgg gtagtttgac cgatttaatt 1770 atgaaaccca taacgtataa agacacagcg aacagggtgt attgagctcc gttgatcagt 1776 ctcagttcct taggtgcaaa atccaaatgt gagctgagaa atatgaatgt aaacttgtac 1782 tcgcctcgtt gcgcactatg tagtgttatc aaaagacata acaaataatg gtactttgtc 1788 atttctcgaa gcgtgttata cagcgagggg cgttgagcgg tggtgttaag cggttttggt 1794 gcggtcaaat cgatttcttc aggcgagggg gccggtttgg tttccaagca aatagccata 1800 aatgttgtca tcaccaaaac gacacacacg aaaggagaga ccatatttat catataaaat 1806 tctgtgattc caacaagagg tgctactact tgtattaagc acacccaatc atttttcctc 1812 ctttcaccca caaatataat gtcacccttc ttttgggaca cttttctatt agggcaacga 1818 cgtccgacaa gcacgtttcc agcaaaaaag attctccggt aagagacgga aggatggata 1824 aaaagtaaat ccaagacgtg gtgatcgtgt cttgatacga atccatatag agtagcgtga 1830 tcagcgttaa cacagaaccg cagacgggaa gaaggacaag tcgaatttta tatttcagct 1836 gattctcctc cttgttggtc acgataaaaa gtaaagtgac gataaattta atcacacttg 1842 taatgatttc aactcttgtc accagcaatg attcgtttcc gtcatgaatg cgtttgctca 1848 gtttagtatg aagtcccatt tttggtatac caataatact accgagcata ctatgaaaaa 1854 1308 SEQ.LISTING.txt tctttaccac aataatggta aaagttatat aaatgttact agacattgtg aagtagtctc 1860 aaagcacaac tgccgtaatg tcctcgagca cttgtttata taacaaaatg ttctaggctg 1866 ataagattag gaagaacaat aataacgaca aagaacctac aaacgacctt tagcttatga 1872 ccgcaatgtc cttttcattt ttgtaaacac tcgtagaaaa tggacgcatt gttatcttgc 1878 gagtgacaaa gtatttggtt gacgaagaca tacacccata tcaattgtgc tgcaaggttt 1884 ttacgatgat tacttgttgt tgtggtgtaa aaaggaggat ttgattaatg ctataatata 1890 ataaaaaatg ataatttatg ataatttaat cagtttatta ttgtgacaac cttacaacct 1896 ttaagtggcc gccagaaaat catacaataa ccttcaaatt aatcgcgttt acgctttttt 1902 aatttgcact caacaacaat ttctttatca gcttcctcgt cttgtaaatt gttccagtct 1908 ggcacgtatt gtgcgcgaac cgctttatag actgtcgaat ttgactccat taaattaaac 1914 ttgtcggctc cagtattttt atcaaacaca ataaacggtg tggttgtata ctctgctaaa 1920 ctttgcggca catctattcc acaatcggag tagatggtgt gtagagtaaa acgggagtgg 1926 tccaaaaaac cttgtttata tttagactct agtcccgctc caatcttcat gatcatattt 1932 tccacgattt caacaaactc ctgagccata tcgaaaaata acttgttaat ttcatcaatt 1938 tggtcacttt ttggctttag atcacgaaaa agttggacgg cgtgcaaata gtgtacgtgt 1944 tcatctttca taacttgcat attaatgcga acacaattgt taagaaaccc gctctccccc 1950 atcagattga tcacgagaaa tggtgttgcg aataaatagc gttcacaaaa aatcatcttt 1956 atcaagaagg cggccttctt cataacttcg tcttctaatt tatacttttg cagcttcaga 1962 tcggagttat tgtgcaaaat ataattaata tatttcttgc ttgttaacat actggtggta 1968 aactcggaag agtgatcggc caaatgcagc attttgttgt atacaatttt gtggatagtt 1974 tctcttgcac cttgatcttt gaacatccac tgcgtacatt cttcccactc gagatcgttc 1980 tcgtcgataa attgcattac ggcgtcgtct cctattgcca aaatggcaaa actgtgtagt 1986 acagcttttt gccactgcga atctaattta atgaatccac tgacatcttc taagggttca 1992 tgctccgttg cagaccaata atttgcttgg tgaagttggt agtagtgcca agagggggca 1998 1308 SEQ.LISTING.txt tacgttggtg gccaaatttt taacaccaaa gtttccgaat tattatattc tggtaggtct 2004 tcctccagac ggggtaatga aagggcgctc ttaaacttgc ctccaaaaaa cttagttaca 2010 cgctccatta tttatgttta gatgatgggt aaatgtttga acggttatga tttgattcgg 2016 gaggaggacc gtatgtatat accccgtcta atctaagcgt tctttttctt atcaatgcat 2022 ttgttatcaa tgcacattgt attaaaagcg ggtcgtgtta aaagaattat tattgtgctt 2028 cgagttgttg actcgtatca acatgctgtc cgccaataag tgtcgtctta ataacctcca 2034 agagtttgga aggattatta tgaaggagcg tatgctcctt gacgatgtcg aaactccgga 2040 agagttttgt cagagaataa gccggggaat ggtgaagcta gatgatgaag aaaagaaaat 2046 cgcgcacgcg accgctcttt taagctccgt ttctataata ccttcgtcgg ctctctgtca 2052 gcacttaaac cttcaaagga acgatacaac tcccagtgcg tgtcatttga cggtgtttag 2058 ccatagctat gaggccttct ccaaattgaa cgaattggat cgtattgcaa aaatggctat 2064 tatgggcacc ggagtgggtg tgggaggaga ctatttgcgt tataaaggat caaatgttgc 2070 gggcgagttg aaaaatagtt ttgtggaaat atgccaatac ttgaacgctg ccacaacttt 2076 gaatgtgtcg gcgcgtaaat cacgtgtggc cgttttcctt tcgctccatc acatctgttc 2082 tatgatctgc ttgacgctgc gccaacaaaa cgctcgtgtg acttcaaata ttttctacgg 2088 cgtcatgatt cctaactttt ttatggaaat gcagcgaaag gacaagaacg caatgtggta 2094 ttttttcgac ggaaacacga cgttggaagg tttatcctta aatgattgct acggcgaaga 2100 atatgaatcc ctctattgga gaatggtaga gaaaaagtta tacgtgaaga agatgtatgc 2106 gacacaagtg ttgggtgagc taatcagctg cctgaccgag aacggttttc cttatgtggt 2112 atggcgagat cacgtaaaca tgtttaacaa tcaccgagac ttgggcacca ttcaaacatt 2118 aaatttgtgc acagaaatat gtcaacatgc gggaagcgat tcgtcctcaa tgtgcacttt 2124 gatgacggtc aacattgcgg catattgcga agattatccg ctttgtaaaa tgtatgaaga 2130 aattgtcgag gaactggccg agtacggtct acaccaatgc tgtccccaat ttgatgagac 2136 taatgaggcg agattgttaa tgcactgttt taccgcctca tatacatcta ctttcttgct 2142 1308 SEQ.LISTING.txt aaacagactt ttgggcgaca agacctcgcg tcgcgagctg ggcgtcacac cgacgggtct 2148 ctttgacgct gtgtatattt tgtgcggtag agatgctgct tacaacgatg caatgataca 2154 ttattcagcc ttggttgcgg aatatatgta tataggctgt gtactttcta gcattgtgta 2160 caatcgaaaa tttaatgtga tctgtgtaaa cttttccaaa agtgaatttg ccaaggggct 2166 gtttcaattt gatttgagga acgtaacgcc ttctctttcg ttgctttgga acagaattag 2172 acctttcatg aagaaaggta tggcaaacag catgctgacg gcccaagcgc ccaccgcaac 2178 gaccagcctt ttgactaatg tgacagagtc tgttcagttt cctatgagtg gggcggtaca 2184 gaccacaaaa aactctggca cgggacgttt tgcaaacatt cccttttttc tatacaaaag 2190 caacgaaacg gatattggct ttaatagacc cgttactatt gccaaacaag tacaggtctt 2196 tgcaaaaatg gctccttatg tagaccagtc tcaatctgtc atcataaact gctcttccac 2202 atacgaagac gtctttcgta ttttgcgcta cacctacgat aataagttga aaaccgcctt 2208 gtattacact gtttttaatt caaacactcc ctacattgat ttgtctgttg tgacgcttgt 2214 actcaataat aataatacga taataaacga ttatatataa acgttgagct ctattattaa 2220 ttatcagtta cagtcctcca cccctaccaa taaacaaaaa aatggcagca gcagaattac 2226 actttgttat ggagcataat aaacctgttc ccataccgaa atttgattat acaccttcaa 2232 acgacgttct ggacataagc cacaatttgg gaagaagcgt gccggacgaa aggataaatg 2238 agctcattga tacgagcgta tacctagaag atttattgcc gctggataag gaaaaattgt 2244 ttgtataaaa atacaataaa acgtttattt tttaaaatgt tctatttgtt ctatttatta 2250 ttcctcgtcg acaatttttg acagtttttc ctctaattct ttataaacca attttcgttt 2256 aatcaaacta attccatcgc acaatagtaa gtaaagcgaa tctaaaataa cctcatctgg 2262 catttgcata tacatgtcta ttttatagtg cattgttgtc accaaaggtt ttaatttggt 2268 caaatccttg taatttagct gcaaagctaa agtaataaaa gtatcttttt gtttttgtaa 2274 tctatccatt tttattcagc ctctttaatc actaaacgat ccacttcatc aacacacttt 2280 ttatcgtttt cgtaaaatga ttttaatgcg ttgtaaacac acacattgtt ttcgcaacgc 2286 1308 SEQ.LISTING.txt ttacattgta tatttttgat tactagaaaa gaaaacttta atctatttcc aaaacgtttg 2292 tttctcggtc gttgtaccaa agcttcaaaa tcgggcagtg tgtttgcgtc tttaaaacgg 2298 taaaatgttt cacgatactt ggcaattatg tctgagcgtt tcttgagcgt ttcaaaacat 2304 atttctcttt ttttcttcgt ctttttaata tttcccacgg tcgattgctc gctctcctcc 2310 agcgtgggac attgttttat catctgcaac aaatttttgc cattgaccaa aaaatgagta 2316 ccgccttgta caaataccgt gtatgcgtcc aaaacactcg accaatctct gcagaacaca 2322 tctaccatgt accgcgtacg agactccacg gaacttctcg gattgtataa cgtgtattgt 2328 tgcgtgttgt tagacatgat cggtgtgtga gctactattc gattttctgt tagtttatac 2334 caactatgac gtcataagat tagcccagat agtgggagag gagggggcaa agtttgtggt 2340 tgcggtttgg tgtttgtatt ttagattggc tagaggaggt tggccgtacg ggagatgttc 2346 tgttctgaag cgtctaccgt gattttcgat catttcgtct accaaatctt tacgatgcgg 2352 cgcaacgatt tcgcaaattt cggcgagcaa ctcttttaca cattttaatt cgtattgcgt 2358 cttatcgtat tgttgttgta actcgtaaac acgatcttcc aatatattac acttggcttt 2364 gtatactttt agtaattgta taatattagg ctggtgcatc actagactta tactttgtaa 2370 gtcgatatgg ttataatatt gataattatt atcggtgtgt tgattgttgc gtgtctaata 2376 tattattatt tgtcgcaaat taactggttg tatttgtttc ctgacacttt ttcccaggga 2382 agacatgtaa aaatatttaa tgattatttt attaatacac ttaatgaaaa tttaaataaa 2388 agatcatata aagtcacaaa acctaaccgg gcttgggatc ctgatcaaat atttgacgac 2394 gcctatcctt ggaaaagtac gattcgattc aaatatgtat gttatacatt aataggttac 2400 tgtgcgcgct tcgtaaatta cgatgacgaa ctgtatcagt ctccagatct ggcatataat 2406 ctcatcacta gccaacaaac tatagctact catttgggca cgacagcttc tgttaaacct 2412 ccatggggcg tagccacaat tggtacgtgt ttcgtgttat tttgttggaa gcattcatga 2418 ctattactgc agttctaagc aataccgtgt tttatttaga atcggctcgc atcacatcgt 2424 tttacgtcga actgtatcta ccgtctttag aagttggttt tgtgcgcaac ataacggacg 2430 1308 SEQ.LISTING.txt tgatgcgtat gggcgttccg tatatgtaca acaaattgct gcataacgat ttaatatcat 2436 ctttggaaat agatgacttg agcgtgaaaa aattaatgca aaccgtcagc tcacccgttg 2442 tggttcacgg aacaggtttg cataaagatt atatacctgt tgagcgaatg tttgcgcgct 2448 cttataacac cattgtgaaa gcatattaca ctctcgatta ttatggagtg ctctttcaaa 2454 aagatgtaac cgatatggag ttgattaata aagctttaag aaaagcctct tgtcccgaag 2460 ggtttataca tcccgctctt ttaccaccac tttttaagag ctttaactgc tcgaatgttg 2466 gtaagctcac cgactaccct ttggggatcc gttcggcgga ttacagtaaa gtgttgtcga 2472 atttgacaaa agattatttt ggcagtaccg tcggtgctac tccacgcttg gcgtattacg 2478 agtcgacccc tcttcacgat aagtttggtc ccgcgtttgc gatggccaaa aaaatttgga 2484 acagaaatta tccagactcg catataattt cacattacca atcgggcgtg ttgtaccagg 2490 cgcataacgg atatgataaa atccattgca ccaacaggga ctttcaactg ttcactccaa 2496 gtataggcga gaccaccgtc tgcacttcgc acacttgtgg tgctatgttg tcacatgcta 2502 aattcaatga actaaacgat cttgaattca aatcttgcac aatatattac gaagagggaa 2508 tgtttcagtt gtattatggt atgggtgtaa aaaaaggcgc tctcatcgac ggagacggta 2514 ggttagtagt aatgtgtaga gcgcaggagc cgtataaaaa actagatcag tattctttta 2520 aagctcaagc tatatttaac gatggtgccg tggaaggttg tcattggaac ggcattagtt 2526 gctactcggt gcccattgaa ggtgatgttg aaataccacc gctcacggtc agagataatt 2532 tgctacacga actagttgaa caggttttaa cagctgaaaa cttgtacgca tacaaaggta 2538 tagccagtta taaattaaac gttgaaggtt taacggataa gcttaaatgt aaaatactat 2544 caggcggcaa caagttttta gtcacaatgg aagaaaacaa aaaagtgctg ttcgcctttc 2550 cgtggctgtt aattaaagag cgaaaactta ttaccattgg tggcgtaaac gaggtgaccg 2556 aaattccagt aaacaccgta aagcgcctat tgcaactagc tgaaattaaa cgagacccct 2562 ttccgatcaa ttgcaatcta gaagaaaata gttttgtttt aaaagacaca agcgaatatt 2568 tacaattcaa atttgagatg gtgcgagacg ctgctaacat atataatcta atgcgtaact 2574 1308 SEQ.LISTING.txt aatggcattt ttaaaaggac aaatgtattg tacataagtc ttttgggtta aattaagttt 2580 tagcaccggt agtggtttat tacctaaacc ctcgttcatg ctgttaagaa tgtcgccatt 2586 gtcggcgtcc agttcccacg caaacaaacc acccaaattg ttgtctatta caaactttcc 2592 cttagcttgc acactcgttg ggttatcgta agtaagtaga tcaccaacat tctctgcgaa 2598 cgcatatgcc gcttgcgcta cagagtcata ataagtgtcg gtgtaccttt gtatcaaatc 2604 tttgtaatct acaactccac tttcccaagt tcctttaatc ggcccctgag ctacacccgt 2610 aaagggattg ttgtttttta tgtcatgcac acccgtccac cctcttccga cattgcaaca 2616 gctagcacta ttttcttact attgacgttt tgttttaaca actcctttgt cgcgtactcg 2622 gcagtatatt tttcttcagc gttccaagag ggtgaataaa gtgtagtgtg atatcccaag 2628 tccgtgttag accaagcgcc tttaaaatcg tacgtcataa caaaaatgtg atcaagatac 2634 tcttgcgcat tttcataatt aactatagag attttatcgt accccgcgct aatcgccgag 2640 gtgagctggt attttttccc tgtttcttta gaaagatcgt ttagcatttc tctgagctct 2646 ttcaataact gcacatatgt tactccatcc ttttctggat ctcctaattc gggattagca 2652 cctttaccgc ccggaaactc ccagtcgatg tctagtccgt caaaaaattt ccatgtgcgc 2658 aaatactctc gtgcggactc aacgaaaacg gcgcgatttt cggcagaact caatttaaag 2664 aaagggtcgc taagtgtcca cccgccaata gacggtaaaa tcgtaaggtc gggattgtgt 2670 cttttaatcg ccatcagttg gccaaaattt cctttatacg gatcgtccca agcgcccact 2676 cctttttgtg gtttttgaag agcgccccaa atatcgtgaa tcgtcacttt aaaatcctct 2682 cgacccgcgc aagatttttg taaagcctca aacgaacccg gcacttgctt taagctatcg 2688 tttataccat ctccaccgca gagaggcaca aagccataca aaagatgcgt aaggttgggg 2694 acgggaacta agtctgctgg atattgtctg tcgtaaacac cccactctac aaagtaaccg 2700 gccaccacat gatccgtcgc tctagtgtat ggtttgttgt tgtcccgcca cacgtattcg 2706 atgggttcca agtgggaacc gtccgtgtcg gctacaacaa tttttaccgg ggcgctaaca 2712 gaacagtcgg tggtgtcgca aagttttacg acggctgaat atgttccacc tttcaaaact 2718 1308 SEQ.LISTING.txt tccacgacaa tctctttttt actaacttca tcttttccac cagtctttac tacgttgtta 2724 ttaaacagga gctcaactcg atcaccatca gaaccgtacc atacatccca tgctacacta 2730 atttgaacac tattgtgtat ttgcttaata agactttcgt atgaaaccgc ctctggattt 2736 aattcaacta gactgtactt ataattaccc catctaattg tgggcacacc aggtttagca 2742 agtgttgtgg tgattagcaa aaagagagac agtaacgcga ttctggtcat agcgtggtaa 2748 ataaaattat ttcttatata ataaggtatt taaacatgtt ttatatattg tttttgatag 2754 gcctcgtcca aggtgcgcta tataatttaa atgacagcga aaagctgttt gaagattttg 2760 tacaaaaata caataaaagt tatagttcgg aagaggagcg tcagataaag tttgacaatt 2766 tcaaaaataa tatacgttct ataaacgaga aaaattccct ttcgaactct gctgtctacg 2772 acattaattt ttatagtgat atgaacaaga acgaattgct gcgcaagcag acgggtttta 2778 aaattaactt aaaaaaaaac aatttggatc taagttggaa tattaagtgt aacaagaaat 2784 taataaatgg aaacccggcg gtgcttttac cagattcgtt tgattggagg gatcgtcacg 2790 tgatcacttc agtaaaaaac caacgtgact gcggttcatg ctgggctttt agcaccatcg 2796 caaacattga aagtttatac gcgattaagt ataacaaact attggacctt tccgagcaac 2802 aattggtgaa ctgtgatgag caaaataatg gctgcaacgg tggtctgatg cattgggcta 2808 tggaggaaat tattagacaa ggtggtgtaa gtaacgaaac agactttcca tacacagcat 2814 cagacggttt ttgcaaacga agcaaggttt cgtaaacatt aatggatgta atcaatttat 2820 actcagtaat gaggatagat tgagagaatt gttaattttc aacggaccca tttctattgc 2826 aatagatgtt atcgacgtga tagactatag tcagggtatt tcgagcacgt gtcgtaatga 2832 caacggttta aatcacgcag tacttttggt cggctacggt gttaagaata atattccata 2838 ttggatactt aaaaactctt ggggatcaca atggggagaa aatggttatt ttagagttca 2844 aagaaatatc aactcgtgcg gaatgattaa cgattacgcg gcttcagcaa tattgtaaga 2850 atgaacggaa ccgttttgta ttataacaac actcgagtat gcactttatt atcttcaaat 2856 ttggacaaca tatttattga tttgattagt aaattagaca aaaaagacga ctttaataaa 2862 1308 SEQ.LISTING.txt gttacgcttg tatttggcgc ttgggtggtt gtaataacta tcaagtttgc ttgtaaacaa 2868 tgttttaaaa aattgtgttc tttcttacaa agagacacat cacaaaggga cacatcatga 2874 ggtcccgtat acacgagagt acaaaattgc tggtctatta cgaatgcaca caggagtgtc 2880 gcgatgaaac gcgccaggtc gataagttaa tctagtgtgt tcttctggac atttgcaatc 2886 gctcacctga aacggacctt cttctaaatt aatatacatt tccccaccgt cacacacata 2892 atttctcagg ttaccaccat cttcgattac gtcacggtac aggcttatgc aaaaatagtc 2898 tacgacaaga ctgtcgagcg cattcaatac aacaatttga ccacgttctg catcacaatc 2904 tgcgggctca atagtgtcga cagcttgcaa ttccacctga cagaagcctg ctatacaagt 2910 aaacagaatt ccgcttctac aattctcttg acattgtcta tcggtcacgc aaggtacatg 2916 aatggatgtg ttgctacaat ctaaaatatt gttcttttca aaaagaagtc gggctctttt 2922 ctcctccatt tcctcttggt tcatcatgac acgtgcaatc cataacataa taattatgca 2928 cacaattaag aatatactaa gcagcatcat tttgcttaag tatggatttt ttctatctaa 2934 ttcatgaaac ttcttttgaa gcccttagca aaatattaca aagcggattc ttgctgacca 2940 gttcaaaaac tcaaaaatta aaagttcgtg gtcaaggttc gtcaaataga aggttggcga 2946 gcgaccctcg agtttcttta acagattcag aatttttcaa caaatacgac gaagttgacg 2952 gtgtctatat gagacttcaa cctaaaatgc atagtatacg atcgaaatac agcgactgtg 2958 ttttggtttt aagaatgaat ttattaaaat attgtaagtt tgtgataaac tctgaggaaa 2964 attttgggtt ttatatagcc gaagaatgtg ttattggcac ttctcaattt tccggcgagc 2970 ccggttttac aacaacttct ttcgaaaaac ttgctctttt aaaagacact acagactatt 2976 cgagcactga agtgttaatc ttacaagatg taccagtatc ttttataaag tttatatttt 2982 tagttcgcga cacaaaagct gacacaattt ttaaaccttt ggcgcgctac aacattaaat 2988 gttttaatat cctataatta agagtataat ggaaatgccg gaagcttata ttttgaatac 2994 cctttacgat gatttgtata aatttatatg gcccgtactc atagagagag gtgaaaataa 3000 tttatggtta gatctggttg cgttgaaacc atactttaaa gatatttgtt taaaacacaa 3006 1308 SEQ.LISTING.txt tgggaagaat aaagtagaat ttgttatact taacgatgac caaaatgttt tttcttctga 3012 ttattttttt gttccagtca aaagtataaa cacatgtttt agcgacgacg agtaattaat 3018 acaactttta agaccgtact gagccagttt ctttggtgcc aacttccacc aatcattcat 3024 aaacgtctag atgatcttaa actcgtttcc atttttgata tagcggattt ttggaacaaa 3030 ttaaaacttt tagatcactt tcaaaaatat tggttgtttc ggtataaaat tgttgtaatg 3036 cgttacgaga atgagaagtg tttaagagaa cagaataatg attccgaaac ttctgttgaa 3042 gatggtgtcg acgacggacc aaaaaatgat tttaaaactt ccccagagat ggtctgcgac 3048 atcaactgtg agacagaatt gaaaagtaaa gaagaaaaaa taaaagagtt agatttagat 3054 tcttcatata ttaatacaat aaataaagaa aacgtttctc ttatcgatag cttaatgtct 3060 aatattgaca aacagtttga aggaatcaag aaaaatgata cagagtacac aaaattacac 3066 acaagaaatg ctttcttaac attattaatt ggaactactg cgttattgga acagttttta 3072 cactggtgtt aaatattgtt tcatagtttt tagcgcattc tatagctttg ttgcacttct 3078 tgtacacatt actcaactct gttttatacc actgtatttt acacttcatt ttgtggtttt 3084 cccgagaagt gttatataat ttatctttaa gtctgtttat gtcatctctc ttcttcataa 3090 ttgaaacaag gtcattagtc aacttttcgt tgttgttttg tagttttagt gcgtcctctt 3096 tcaaagattc tataagtttg gttgtttctt ttttaaataa ttcatgtgtt tgaaagagtt 3102 cattatatcc cttaacgtga tctctgtgta gctgcagatt ttcttcaatt tttttttcta 3108 aactgttaat cttggaggcg tttgctcgca gtttatgcat agctttcaca cattttattt 3114 ttttgcaaca atccttttta ttagaaacat ctttcttttt aattgaatct tcgttacaat 3120 aattgtcttc ctttttaatt aagtcttctt cctttttaaa taaatcttca aaaagtttta 3126 accgttgttc atattcagat atgcaagcgt ccttgtctcg tataatttgt tttaaagaag 3132 cgatttgttc ttgtagagta ataagcggat cttcataatg aaccaaattt gtgtccaaat 3138 ccaataacaa atcacacaag ctctcgtctt cacacatcgt aacgcaataa tgagccgata 3144 ctgacgcagt tggctggtgg caacaacatg ataaggtttt gtataaagat caaaatgtta 3150 1308 SEQ.LISTING.txt tctactcgca cgcatactgg ttagaccggc tacgcaagta ataacaagaa aatggacgcc 3156 gtggccagaa tacataattt gagcaataaa tttacattac atgttttagt caaatttcga 3162 gtggaagact ggagcgacga atgctacagg tgtaaatgtg ttggttgtaa atggtgtaaa 3168 caatttgttg tattgcaaat aataaattgc tcttccatga agccggtgac caataaaatt 3174 gtgtaccaat acattgatcg aaataaacca acatattttg atgtcgaagc gagtaatttt 3180 tacttgagag atggtatata ttatttaaca aagaaaataa ccaaaaaatg tcttcaaaac 3186 tttgtattta aaatgtaata agctctgtaa taaatgaatt aacacgagtt gttgttttaa 3192 tactttgggc tgaaaattgg taacattaca tctctattgt tgtaagtgca gcagcagccg 3198 caatttcttt taaaatataa aagtatcatc gtaaacaaaa ttcctaaaat aatgtataca 3204 acaaacttga cttcccacca ccaatttccg aacaagttta ggtaccagtt tgaattagaa 3210 ttatcatcca attctttaat atctaatgct ttttgtgctt cttcgtttgt aactaaacgc 3216 tgtagagtgt gcgtaatttc gctagacttt cgtgatccaa actctttata atttttccgt 3222 tgctgttgta attgggtggt aaataaaatt tactaaagtt aaactgaata actttaaatt 3228 tactttcatc aagctgcacg tgtttggaaa ccaaaaccga tctgcttgtt ttcaatttac 3234 aatattgtaa aagcgtaatt attccggttc cgtttatcct tgtttttagc tcgaaacttc 3240 ccgtaccaca attgagctgt acaagtatag gtttttctac catatacagc catttattga 3246 cattgttaag actataaaag atttcgctgt aaaatttcga agcgtgcacc tcgcatttgc 3252 tacgcacatc catattgtaa aacattttaa cgtcacagtc gttagtgtat gaaatgtatt 3258 tgctcgtcat cgaaccaaaa cacaatgtta aattttctaa tacagtacat gtactggtgt 3264 cgtctaagcg tgtgtaatac atttgttttt tttcaaaacc tatgtactga gattgagcgg 3270 aaagaaattt acaaattcgt ttaccgttac attgcggaac aggaaccact ttgtacagtt 3276 caaattttgt cttgtccatt ctaggtatct gcagcacaaa catgagttca tcgtcaggat 3282 taataaaaac actacagtgt gtaacatgca taatagtatg cattttctct attacaggat 3288 cgctaatcca ctcagtttcc ctatcaagac tttgtttgtc tacctgtacc atttcgtcta 3294 1308 SEQ.LISTING.txt aaactaattg tgggctaatg ataaaagtgg aaagacgacc gctataaagc gataattgta 3300 cggcggtgag aattttgctg taggtagttt caatctcttc caagttgtcc tttatgtaaa 3306 ctaattggcg ctctaaaaag tggcagctca cgacgttttc tatgttatgc tttacgctat 3312 tgagatactc cgtaatagaa agagtttcgt tagttagtac tttaactctg tagtcggtgc 3318 tgttttcatg cttggctacc tcataaagaa gggccgcgtc gttatcgtcc atcaatccta 3324 ttgagtattt gtaaaaacgt cctacaaaat tgaaagctcc tccgaaaagg cttcgtcttt 3330 ttcttttagt gccaattttt ttgtgcacta atagaaactt tatactgtcg tgcgcttcgt 3336 acaaatttaa aatttttctt tctttaatgt acttcaattc ccgttcatat ccacccgcgt 3342 cattaaacgc gcaatcgtgt aactcctttc cactgtccat tttttgaagc aaagaagaac 3348 ataattcctc caattgttta agcctgtcct ttagaacatt ataatttaca tttaaaataa 3354 aattccaact atttacaaca aagcccaaat tgttttgaaa ttcgtaatga aaaccgctaa 3360 cattaaagtc ttggttttta atatatttat ttatttcatc atcaacaata ccatcaccgc 3366 caccctcaac gaaagagaaa ataaaaatta cacaaagaat taaacgaaac attaaagtaa 3372 caatacatca tttgaaacgt ttatatacca ctatacaact atgcgttttc aacagtcaac 3378 gtacaatttt cttcattttg attttgtatc aaataacgta taaacttatg gcaagagtga 3384 agattgtccg ttgaaggact caagtcctgt gcggtgcaaa atttatgaat agtttcaatg 3390 tactcccaca ttttgttcag cttacagtgt cgatactttt tcggcgtctc ggagaaccga 3396 aacaagtctt ggttacccat aaccttaagc ttctttataa gcggatttgc acgcttttga 3402 ctcttgtagc ctacacaaat actaaaagca ggctctagct ttaatgtttc gttgtgaatg 3408 ttggctttca caccctttgg ttgtttgtat gaattattaa aaaagccaat cacctctctt 3414 ccaacataaa tgtgcacata actttttagt tcctttttcg gcgcaatgtt ttggatcgcc 3420 taatggtggt catttgttcc actttctctt taatcaaacg aatattctcc gtgagcatcg 3426 ctggctctgc tataatctca tccaagcgat ttatcaagtc ttcaatataa aaacgcaccg 3432 gcgctttgtt gggtttcttg ctttttggtg gcggtgtcac ctcctccttt ttaacctcta 3438 1308 SEQ.LISTING.txt catcttcttc actttcttcg tctgatgacg aactgctatt gtcatcatcg tttccgtttg 3444 ttttttccct caatttttca tcgtcatcac tttcaacacg attctccctt ttgacttcgg 3450 cttcaaacat ctccgggtct aacatattat aattcggtcg catctcctcc gagtgtggta 3456 cattaacatt cggcataaca aactgttctt cctccgctac aaattcctgt tctgcaatat 3462 attgtgaatc tcttctgcgc ttcgctgcct tttcttctga agaaacgaac ggttttggtc 3468 gcttcttaat tttatgtggc acttcttgaa tagagatcac agctttatga cactcgtcaa 3474 cgtcattttt aaaagtaaca cgtttggtgg ttttgctgtt aaaaatcttg ttcacctctt 3480 cattttcttc gtcagagaaa tgaagatcgt gttcggcaac gtccatggtg ttttaataaa 3486 tatatagcta acacgaggta ttaacaagct gatgttcaac agctgaatgt gattatgtat 3492 gaggagaggg ttgattatat atcaataaag agaccatcat gtaatctatg atttattaaa 3498 aaaaatatat tgctaatctt atctctaact ctaattaacc agctgacttg atagataaga 3504 aaaataaaat aatactttaa aattttgttg tgaggagaga gcgaattagt aaacctacag 3510 agcgctcatc tacatctcta tacgtttaaa atctattact ttaaacgcac attttccgct 3516 atctaatgcg gaccctaaat ccagtctttt ctctccccaa aacacataaa atgcaaattt 3522 acgaatcaaa ccgtttaaaa tttaaatcag tcaggtggtt taacaaaaat tccttacact 3528 ttcgcttata atctaacgta ttaaaagtta aacgcttatt gcgtttcttc tcaacacctc 3534 tgtatttctc gataagtaaa tcgctcatat ttgcccaaag gctgctcaaa tctgtttcgt 3540 caccgtctac catgggataa attaacactt ctttagtttt catagctctc aacatataac 3546 tcacccctcc aatcatgcaa acaatatcat tgttgtccac ataacagcta attccctttg 3552 gactcttttt acgcacacgt cgaggagcct tggccttctt atgtatcttc ccatcatcat 3558 catcgtcgga agatgattct gatgaaccat cggtcatggt actactaact tcgttgcaca 3564 ccgctactgt agcacgcctc atcataactc gcgatgccgc tacttgtttt ttcgtcgtca 3570 ccttagttgt ttttttattt tcaacttttc tcttcgcctc agtagtaatc tctttctcct 3576 tggttaatcc ttcgactgtt ttcatttcta tatcttcctc ctcgtgttca gtggtaatct 3582 1308 SEQ.LISTING.txt cttttttttt ggttaaatct ttgactgttt tctcttctat aaaatcacct tcctcctcgt 3588 catcgctgct ggtgtaaacg agcgacgttt tggtaatttc actctcgtag accggtggtg 3594 gtgaacagat attttctata accgaagaag atggagaaag catgttctcg ttgcacggcg 3600 atggaatcgt gaaggtgtgc attattcctc ccgaaggctc gtaagacggc atgtaaaaca 3606 aatcgttgtt gttattgttg ttgttctgtt ctttagttat tatgtaactt tcttcttctt 3612 cttgactgtc gatgttggcg ctcctctgtg atgggggaaa cggagaaaga aatggtggta 3618 acaacgcttc ttgtgcagcc tcctgtacat ggcaaagcat gttttacgcc tcgcacacac 3624 cttcttcgcc acaggtcctc gtgcctcttc actgccggcc cgtttcaatt cgcgagcgta 3630 catcttttca aagtcgacac tttcccgttt taggcgcatt tgaaaacgct cagcggcctc 3636 ctgcgaggcc aaaaaattgt tctcttcaat tgtgacgcca ttaagtaaat cgctaagaac 3642 actcttcacc tccttgtagt ctttgcgatg atgagcttga aatattttaa acagcttgta 3648 caaaaaatgc tgcggcgtct ggggcgttgg tcgcgaaaag caagaattgg gtcgtatcaa 3654 aaattcgtat acggaaacaa agagtggatc cataatgtaa ttaagcacgt ctcactttcg 3660 aaggcgcaaa atagtcaatg cataatgccg actgggtcga acattttata tgagccgcca 3666 gagataagcc agcgggttta cttgaccttt tttcgataag aaaaaactta ttaatttttg 3672 aagcgtccgc ctgtttcgta aattatgcat tatgcgtcct tttttataaa caaagtctgc 3678 gctgttgaca ggccataaat tgggtgcctt tattttcatt tatttctata ctaaaaaact 3684 cgctccacag gacgtgtgca tactaatata taagcttagt gaacctttag catttgagat 3690 gtttttcaac cttggaataa attaacaata accataaatt ttaaaacaat gttttattca 3696 tgatatcctt ctcgtcctat gtatcactat ttaaaataac atggtacaat tgtttagtac 3702 ggctacatat acgcagctgc gaatccactt tgcaagctgc ccagcgcata acaccaatct 3708 tgacgctttt aacaattctc cctctagcgt cgtatatggg tctccatctg taaaccattt 3714 tataacgctt taaataatag gtactatagg tttcaaatac aggaacgggc atacttgttc 3720 aaactaatga tgctacaagt gaaaaacaaa tctatttatg tggcgctaat ctttcacctc 3726 1308 SEQ.LISTING.txt tttatcatca cacctgataa cctacgtaac actgataaac agagctgata acctacgtaa 3732 cactgattat ttcactcaca catataaaca atagatatga tatcatactc acacatacaa 3738 aaagcagata tgacacgaca gtaaagataa ctcctttgct ttctgggcgc ctggtacttg 3744 ggctgggcga gttcattttt taaaatcttt aaaggcgtcc cgtcaagaac caggataagg 3750 tctatgctca gtaataattt atatgaaacg agagttcatc aatactggtc attagtcgac 3756 aaaaattcaa gacctttctc ccaatacatt ttcctctgag taaggatact ggtcgtaaaa 3762 atttttaaac agcgccatct gtttttgtta gactaacaac tagtacgcca tctagtatca 3768 aaccatcaaa ctacaacagc gacgtcgcta ctaacgccat ctattggcgc cacgattaaa 3774 actgtgcgac cagcttacaa gatctcttac tgctaacaaa attaactaat caatatatca 3780 accttttttt gatgatacca accactgaga cagacccgtg tctcggtata tttaattagg 3786 cgagagagat cttacgctgg tttcaaagac tttgcagttt gacagtgttc aaaaatggaa 3792 ttttccgcta aagtaccagg cgcccagatc ggtgaggagg tttagcaagt catgctacgc 3798 gcgccggcca cgtgaccaat cagtccacgt gccgctatct tatcgtctga cctatttgac 3804 tttgttattg tagcaatcgg cattatcttg tttttaagtc gacactatct tgtttttacg 3810 atatttatat cttatcaagt aacactttag atatcagtga cctcgactgg cggatattgc 3816 ttcttatctt acctataaaa ggccgtgaag atgatgtcgc acttatatta cgctctcgca 3822 gcaagcagtc aacatcctgt catctccgca gctctaagtt catctccacg caataaagat 3828 gtcttctcct aaggtgagtt ttatattatc ttattcttct attttaaatg tgattttaaa 3834 tgtgtatact gtgctcacac cacaggttcg ttgatcgttc ttcatctatt ttaatttatg 3840 tctttcttct attatagccg gttatatttt gttatagaaa aacacctgtt tccgttttaa 3846 gaggccttcg tctgaactac aggctgctaa ccaagctatg gtttctgcag acactactat 3852 tgacagaccc gattttgctc ctgtagctgt taaagttaaa gttatggacc ccgttgcgga 3858 ttccctaaag cataacgctc ctatagttac atcttcaatt actatattac cagtaattaa 3864 cttacccaat gggcctgtga ctagtttaac ttgtaataag ccaatacaag ctgtcggcca 3870 1308 SEQ.LISTING.txt gtttaatgct caacacgaat tcgtagcatc atgtaattat aaagagccaa tagtgttaga 3876 cgaagcagat cacctaggcc ttgtctctcc taaactgttc tttcctttac agtataaaag 3882 ttcgaaatcc gacttacctc cttatgagga attttgtaaa tatttgcgta acgacgtact 3888 attgtataga cgagatgctg tacataaatc tctcatagag atcgatggta cttggattcc 3894 taatgttttt attgactgtg agaataggaa actgtcgttt aaaggtccca atggaattct 3900 atgtcaacgt tatatttttt gcaaaccaac ggctgaatgt aaaatattgc cagtggctct 3906 gttttctaat attaaacgtt ctttatattg tgtcacctat aatctaaagc ttaaaagaga 3912 aattatgact gactttgatc caaagtatat gtcttttatt gtatttaata aaaaaactgg 3918 tcggttttac agaaattgtt ttgcatctat tatttcaagg tccaagctta gtgttagatt 3924 ttatgttatg gatttgttga aagcgcagaa cttagtttgt atattaatta agaaacgttt 3930 ctttactgcg gagtatgtaa attagttaat tagtacgatt atgtaacaat aaacttatat 3936 tcttttgtta aacttgtctt ttttttcttt atagtcaaaa ccctcttctt cctactcttc 3942 atcatcggac gatgtggaga gtctgagtcc ggccctgatg cggcgttacc aaaaggaggt 3948 ggagcgtcag gcgaaacgtg aggctaaaaa gttggctcaa aaggcaaagt tggataaaaa 3954 gttaaaggtt aaacttcaaa aggtggtgaa caccactgag actattactg taacatctac 3960 agatgtttta gagttacact ctgtggtgac tcaatcaaca ttgaatagta tggatcccat 3966 ggtggccgct tttccaaaca acacagaacc tttgaatatt aaccaattga ggttggttgt 3972 tcttaaatgt tataatatat tgttagatag tattttgatt aatgttaacg atgagttggc 3978 ttctcaagca caagaaatgg ttagcggtct aaagtcggct ttgcataaat atttgaataa 3984 cgaaagagat ttgacacagg cggcttttaa tgttttgcag agttgtttaa ctagatcttt 3990 tgatgaattt tacgacatca aggccattct tcctataacg ataacaacat caaacacttt 3996 gaattcaatt tgtaataatc tttctaacac agataattta gatgttatag aaccattggt 4002 tacagctact tatagcttgt gtcaaaattg taaggtgttt cagaccgctc aaaacttgcg 4008 gtttaaatct tatcgttatt tgggtttaac tacggagcag tgtatagaag cagactcttt 4014 1308 SEQ.LISTING.txt ggttaatgat gaaccagcgt ttttgaatta tattgagtca aatagaaagt ggaggtacaa 4020 caacgccggt tatatgttta acgattcaac ttgcgtattc taaacgctga cgatttgtaa 4026 aatagatttt ttgtatatta ttattgttat tatttgttat atatagttat agtggttatg 4032 gtgttaataa atatagtggt tatggtgtta ataaatattg aacattaaac aagaaaactt 4038 tttattatca attcctttta accattgcat gtttcacacg acgggcaaag ataagggttc 4044 atttagtata gcaagaatat cgttttcttt cttactaata ctacacaaca gtctgtcggt 4050 cttaatatca cacacaacat cagttaaaaa tatgtttgca aaagcattta tcttgtctgg 4056 taaagagtta tcattagtta tagcgtcttt aataagactg cccctatgaa catgtttaca 4062 gactagcaaa ccaaccccta gagctgttat ataacatttg ttgctatcac aacaaggatc 4068 gaggtgtctt aaagttgttt tctcacattc cggcaggcag tgtaacaagt tgtgacttaa 4074 acgtaaaatt ttaagcactt cgtcggcacc cacccacaaa atcatgtcgt taaaaataag 4080 cggtacacat acaccgtcaa agttcaaagt gaaagggcag gagtattgag gcatttttta 4086 taaataactt atattctctc cttgcttttt atatcaacct tttttaagat ttgctgaaag 4092 tcatctgtgt aatcgttgag acgtttaacc tctttttgca aactattaag actttgagcg 4098 acatcttctg aaagaacatt ttttttaccg tcgtttagga cgttgggtgt tatgggagga 4104 attgaaggaa cggggtacgc ctcatcgtcc catgccgctt ctccccattg cgtaacaacc 4110 ccttgcgtaa aagcattgag ggtggtcaca agatttggta aaacatttag tatattagcc 4116 acatcgcttt gtaaatcagt aatttgacct tccaaagcgg ttaatcgagt atcaaaggtg 4122 tccagacgat tgttaagatt ctgttccaga gtgtcgagac gggtctcgag ggtgtcgaaa 4128 cgagcattta tagaggtgtc tagatcaact acagatgatt gtattccgtt aaccaaagtt 4134 gtgagggcag caattgcttg taaaattggt gtgaggtcca cgttaccacc acctccccct 4140 ccattattaa tcagtttttg aatatctgct agaatggcct gaaggagagc gttgttgttt 4146 tgtactccta aaaggatcgc attaagatat tcacatttac caccaccccc gccgccgttt 4152 ggaggctggg gacatggacc gcaaccggag ctgtggccgg gcggtatcat acattgtggg 4158 1308 SEQ.LISTING.txt tttgaagcgt tgcaggcgct agggtcggca atgtattgag cgatggtgtc aaacatacgt 4164 ttaaaagcgg cccagtttgt tagtttagtt tttccaaaat acactgcaaa acccacttct 4170 gttgtgaata gtttatttgg tgggtaagtg ctgtcattgg gcgctaaatc ctgccataat 4176 tttgtttcgc tacgcggaaa ttcgtccgcg tgcgtcttgc tatgacctaa aatatttagc 4182 aattcagcga cgcccacata tggtttatcc ccaggcgcgc ccccgtaaaa cactggcacg 4188 tcggtgccat ctacacgagt cgaaaatatt agcctggcca tgatgtttgt ataatatatc 4194 ttaaattaac tcaccctata cataagatta atttataatg gcttgcatac ccgcagattc 4200 aaaagcattc ataaaacctt ttgagggaac agacgttacg tgcttagtag cagactgtgt 4206 cgtttggttt ggcgccgatg agatcagctc catattgaat ctcaaccttt gtaattccat 4212 aaaacatcta ccctacaatc agaaatgctt atggaaagat ttagaaccac aagttaacag 4218 tgaaaaacaa tttgtgagcg gtttgggtgt gaggttgtta attgcaaaaa cacaagaggt 4224 ggaggagatg attttaggag aagaaggagt agtcgcggaa ggagaagaag aagtagccat 4230 tgcaataaac gcagaagcag tcgttgcgga agacgcagaa gttccagtcg agaaaggaga 4236 aactctagag actgtttggc gtattataac aacaccccat tagacatacc gtgtgcgccg 4242 ctctcttgta cgcttccccc caggtttgaa cttagtgaat gcatgcataa gctcggtaac 4248 atttttatca acgaggccat ttatgattca cgagcctatc ccgatttaga taatattaat 4254 tacaagatta acaagatata tgatcttgta ttggataaaa gtaatgtgat aacgtaacat 4260 tttgtataaa aggaatgcag cgcgctttgc aaccaatagt ttctttccgt cttcaaacct 4266 acaaacttaa tcaaaaaaaa atgagtctaa aaactaaaga caccaagcca aaggcaagag 4272 atacattatt ctacacaaag cttcgtaaag acgcacatgc tcctgtacgg ggttcggtgg 4278 gagcggcggg gcttgactta gccagtgttg aaaatatcca aattccgcca ggagaaaacg 4284 cgctagttcc cacggggctg tcgatcgaaa ttccaaacga ttgctacgga agaattgcgc 4290 cacgttcggg tttggcgctg aggtatagtg tctctgtaca tgccggagtc atcgatccgg 4296 actacagagg tcatctgcaa gtgctacttt tcaatcatgg aaagaaaacg atggaaattt 4302 1308 SEQ.LISTING.txt tgaaggggga tcgtattgcg cagttggtgt gcgaaaagat ccgctttccc gaagctgtag 4308 aaaagccgaa actatcagaa acggaccgtg ccgaaggagg gtttgggtcc acgggaattg 4314 ccagccaaca acaagaggaa atttcaagtg aagaagagtg tgattgtcct taagcaaatt 4320 ttgtattgtg taataataaa agacataatt ttgtataaag tttaataata aaacaatttt 4326 aacacgtatt ataatttata acttttcaac aaaatccttt aagaattccg ttcgtttttc 4332 ttgcaactgc ttgcgaatct cgtaaggttt gctgtcgagc tttgccagct tttcatagcg 4338 agtagaaact ttaacgatgt catgcttcat acggttcacc gtcgacagct gttccgtaag 4344 aggacgtttg aaaaaagctg gaggggtgtt catctttcta tctcttgaac ttgtgtgcga 4350 catctttatc ttgtctacgt gattatatac tcgagattat aagtaataat aatacagcag 4356 catgtcgttc tttagaggtc taagacgaac caataaaaca tatcccaatg taaactcatt 4362 catttccgac cacaataatt tgattgcaaa tgtcacaccc agcggtttta atttaggacc 4368 cccttcaggt ttaactttag gtccgaacag agttcagccc ggttacaata ttaacaacac 4374 ttttgtaccc aattcagaca ttaatagaat catgagaact aacaatccga ccggtatgag 4380 gaccctcttt cccaacgcaa ataacagcca gattaatggt ttgagcagat tacgtgccgc 4386 agataatatt ccagatgctc aaatttatgg tttacaacag cgaaaaaatt cagtgaaaaa 4392 ttctcatcca gatctggcca ctagggatcc cactcaaatt gaggccgcct taaacaacaa 4398 tcctagactt tctacatact tgaagggtct cggtaccgtc gctttagtgg gcgctggtgt 4404 ttatttaata attcagggcg gtaacttagt agcttctatt gttgccgcat taaatcgcac 4410 gggtggatct tattacttta gaggtaacaa cggggccgaa agttttaata acatagagag 4416 ctgcattttg agacatcgaa cttgcggtgt attgttggaa gacatacagc cgtatctatg 4422 tcagtttgac ccgttagatc tcgccaatca ggacccatac tacctcccga ccaggcgagg 4428 gaaatatgcg taggatataa ccgagaaaga gaacaaaccg tatgcagagc ttcggatagc 4434 aacgctcatc cagactctcc ggcatatttt gatattagcg atttagatgt caatcagacc 4440 atacaatgtt tggagcccta cgattttgcc gatttggtag cggatttggg tttagacggt 4446 1308 SEQ.LISTING.txt ctacttggtg aaaacggcct catttctaac atgtccaata gtctaaacag catttctgaa 4452 aattttatga ccatcctttt cgttatcggc ggtattgtac ttttattatt tattggtttt 4458 atgatattta gggtgagtat gagtaaaaag tccgagtaat tccactatct aatccgataa 4464 cagttgcatt tttgcgataa cagttgcata taaaagaacc atcgaacgag gtaacatcac 4470 acaacgactc tacaatcgtt tacctgcatt attactattc aacatgaaat actttgccat 4476 cgacggtgta gccgctacaa ccaagaccac cattttaaag caattggaag gaaaattttg 4482 tgtacatctc acagactaca aagagatacg ggaacaattg caattgaccg aaagtaaagt 4488 tttgagtgaa tttgtatatt tactatatcg tttgtgcgat gaagtgaaga ccgggtcggg 4494 aagacacatt tttgatcggc aacctgtagc tgctatctta tatcagctta tacatttaaa 4500 cgctcccgac agtgtagtgt tccgatacgc ccgcctcatc aaatacaaca attggaacaa 4506 gaattggttt tctctcataa tattgacgaa ggagggtcaa gaggaaaatg tagtcgaaac 4512 tatggtggaa cgagacaacg ggatcgattg ggcggctaaa gagtatgttt tacgccagaa 4518 tcgtgtcttt aagatatggg ccgacgttat ggagtatcca gtgtattatt ttgattacaa 4524 gaaagacttt aataagcagc agaaggaaat cattttgatt gtaaaaaatt taatgaacga 4530 ctattttcct ttgccgtggt acaaaaaaat tattaacacg ttcacaaaga acgttacagg 4536 aaagcgtgtt tttttgtaaa atgatgtggg ttgtgtaata aaagcattta ttaaaccaaa 4542 tgaacatttc taattttctt ctgaacaact cctttttaaa catcaataat gaaatttgtg 4548 aaaaatacaa actgaagtac aaacacgacc tggacactaa ttttattcaa caccaactct 4554 cgcctcacaa tttaatagtt ttacgcaata caataaaaat tattctctca ttacaagaac 4560 actatcccca cacaatgttt atatttgaaa gcgtagtctt cacaatacaa ttaaaactct 4566 atcaatactc gctaatttta aaagatttag acgacgagct tgtcggatgt gatgtcgact 4572 tagaccattt gagaagtttt aaaacttttc tcgaggcggg tgtcgacatc aactttgaga 4578 cgattgatta cgaatatatt actttatatc gcgatatagt tgtagagtgt ttagaagaga 4584 gcgctcgcgt agttcgtaga atattcttag ataaagatga agcgtatcga ttttataaag 4590 1308 SEQ.LISTING.txt taagcgtgaa tcatagtaaa ttgtgcggtg tatgtaaaga agagaggtgt gatactttta 4596 aaacggagtg tggacacgat ttttgctacg agtgttttat aaagtgcatt agtgaaaaca 4602 attcgtgtcc tttatgtcgt agcgtaaaag gttttaaata tgtaagtgga gaaaagaaag 4608 acgtgttaaa taaaataaaa accacccaca atgattacaa attgtcttgg tcgagcgaac 4614 ggtgaatata tacgtaagag atggactccg agttactcaa gcacgttttt atagcaactt 4620 attttgactt agatcagcga gatcacttga acagcgatgt gagacggttt ttaaacgagc 4626 caaggaagaa gatgttattt cttatcttga ctatttggac cgcatgcagc ttaaaaatat 4632 tgttgtagat aaaagtgctg atttatttaa atacattaaa ccacagttta aatatgtttg 4638 cgaaagagag tacgacttgg acattgtaaa gtataattat tcgggagtgt ttttgcgaaa 4644 aggcgcggta gtatatgcaa caaatctttt cgttgtggac cccagtgata ctatttcgtt 4650 ttttataaca aagtttggta tcgagaaggg atacacttca atagaagaga aacatgtggt 4656 gtgtaatgga accgacggtg tttttttcgg gcgagcttat ttggactggc tgggtctaaa 4662 agtgtgcagc ggtaacaagt atagagagga tgaacattat agactttaca ttattgggga 4668 acatatggcc cagcagttta tccagaacaa tataggtgct ttggaaggaa gtgaattgag 4674 aaatttttac aaaggcaccc ctcttacata tactaaaaac gctgcaaaca taattaatca 4680 aaaatctttc gtaacagaca acatggacgt tgtgttcgac aattttgcgg aagagtttga 4686 tcaaaatgta gactatatta aattcgtcca aagagattat atttatgacg cctctaattt 4692 tcccacagat cttttagagg agcttcaaca gcattatgtc tctctcacct ctgtttataa 4698 aataataaat cgttttcaga aaagttcaat accaatggta ggaaaagagc tggtagtgga 4704 ccgttatgcc gtcacaaagt acaaaaagat gattaccacg cccgactttg ttttaccagg 4710 ccgagagaac aatatgcaca tatttatacc aagggatttt attcagctta gacacacgct 4716 gaatgccgcc tttgttcctg agttaggtat tgtaatactg gcggagcatg ttttctttgg 4722 agcaaatcgt gtacttgatt ttgatccgag acgaggagat ttgtacgtgt tcgttaaaag 4728 aaagacaacg attgataagg atgaagtata ttatcacata ggtggggagt tttatttaga 4734 1308 SEQ.LISTING.txt ggagacacaa tttgcctcca accaaatccc cgtctttgtt cttgtgagaa tcgataatga 4740 tttattagta agagataatt taagaacttc tcgtaaatta aaggatttga attataactg 4746 ggtcgataat actattttaa acttatttgt aaaaaagtag atggacacgt tcagagcagg 4752 tgatgcaaga ggggtggcaa caccccctcc ggaaggaaat tatacgcgac gtgttatggg 4758 tatggagccc ggcgccttga tgacaattct tattgtacta gtaattataa ttctgttgat 4764 tctacttttt aatatgagca gtaacagtga agagagttcc ggaagaaacg gtagaatgat 4770 gtttaacaac ccactaaata cgactatgcg caacaatccg ccggtcgtaa ctactgcgac 4776 cacaactaga gctctgtagt agtaagtctt gatggatgta cttagtttcc cgacattaat 4782 atttttgatt cttgttattt taaaaattta catatttcat ggttataaaa tgttacaacg 4788 aaaagactgg tttatgaata atatatgcat cgacgggtat tacggcttcg ctgccgatcc 4794 tttcgagtgc gatgtttatt acaaatgccc agaaaaaata cggttttact gcgacgttgg 4800 tacgcagtat gacgcagaca aatctgtctg tgtacccaat gatgaggtca acggttgtta 4806 cgagataatg agaaggaggt tgctcatctg aggtatataa aggccgcagc cagcgttaac 4812 tagtcactct tcaatggtct tggttggagc caataactac tactctacta ttatctacaa 4818 tagtcctcgg ttcgctgata cgcaaaacat gtaagtaatt ttcgctgtta actttcatct 4824 tgttaaacgc ttgtattaaa tccgttggca tatatctctt acacggatga gctctttcgt 4830 acattcttcg ccgccaatta aaattttttt gtaacgcctc ccgctcacgt attcgtatac 4836 ctttctggcc cccaacacat accaaaattc cgcatgtctt ttagaactca ccttgacaac 4842 acacacgctc agttgacgaa caagatccgg gtataatctg tctgttctaa ataaactaat 4848 tacgtaagtg ttccgaaaac gttcgtcatt ttctctgttg actatcatct ctgcatagtc 4854 ggtgattatt tcaaagcggc aatttatagg tttattattg tcgagtccgc tcaccgtttt 4860 atttagggtt ggttctggaa cattattatt taaaagacag taacaatgtt gtatgaagga 4866 gttgtgtgtg ttgcaaaact ggaaaacaac ttcaacgttg ttagtaaaat ttgctctccc 4872 tagtctaaac ataatatttt gatttcagaa aatggcaaac ttttataaaa tggatgtaga 4878 1308 SEQ.LISTING.txt ggaagacgac gaagcggcac gtccaatcct tttagaaacg gcagactctg agtacgaata 4884 cgaagaagat gaggaagagg aagaagatga aatgaaaccg cagaaattta aaaaagaact 4890 ggagacggcg gcggtgtgcg aaaacgtttt agatttgagc aagggaccgg tgctggatga 4896 aatacgaatg gatctgtgcg acgattttaa actaaccgac gatatgatgg acacttacaa 4902 atggctaagt atgtacgaga gtacatctac ccatatgtat gtttgccact tggatatgga 4908 ttacgttagt aatgagaggt tcgcgagtga cgtctatcaa gactgttatc attcccttta 4914 tggaaacgct tatgagtatt atgtgaagca aattaaaatt tacataacgg tcgcttgtct 4920 acgctacaac aatatagatc cgaagaagtt tcctacagat atggtggata agaagaaaga 4926 tgtttccaaa ctagcatatt ttcttcagtg taaaacaaga aacggtttaa cactaaagca 4932 gcaactcatc tatgcgcttc acagcgttaa tttgatcggc ataccattta aagaaatcgc 4938 tgaaattcac gccaacttcg actctgtggt aaataatcaa agtttaaaaa accttaaaag 4944 ccgctatact tggaaagggg aagaagagaa ggttaaacgt ttaaaagaaa acacggataa 4950 gggtatgtcc tcggtgcaag agttgtttaa acacacattt catcggggct ttatgcgttt 4956 taaaaaggac ctaactttgg tgcacgagga ttattttcgt ttgtttgaaa ctgctgtggg 4962 ttataataaa ttaaaattga caccgtatca ggacaccata agcagcatta aatggatctt 4968 taaagatatt gttaaagcgc ttactgacaa tttggctttg ttaaatttta aaacgtttga 4974 gtctgatgag aaagaggtta gagaattttt gaagctttct cagttaaacc ccgcggggga 4980 tgtaattttc cacacgaaga caaaacatag aaatagagaa cattatagat taaattgttt 4986 tagaatggat agtgttcatg tttgggtcaa cacaatggtg tttgataaaa atgattctag 4992 taagaagttg gatttagaga gtttaattaa agagtttaat tggggttcgc accatattat 4998 taaagctaaa tatgtttaca atttaaaatt agcaaagttg catatagaaa ctgtaaaact 5004 agttatacgt tatatcctgc aaagaagaga ctttagtctt cttaaatacg atgttttaca 5010 tcaaaataaa ttggagtaca attatatttt ttgtagcact taaaagagct tctttatgga 5016 taatgccgat ggtgattcaa aaaaggtttg cggatttttt caatcgccaa gttggcatca 5022 1308 SEQ.LISTING.txt tccacgagaa gaggtttata atatggagag agtgttgtgt aaatgtttga ataaaagtct 5028 tttataaatg ttaatattga atttttattc actgaacgtg tctctgctat caaaatcgac 5034 gtgtctttct ttagtctttt ctaataaatc ttttatgcat tccaaaacta tatctttggt 5040 gttttcgttt aacattaaaa caaatccctc aatcagagca ttaagtgtat ccaaaaagct 5046 ggcatttata tccggtatat tttggacgta aagacataaa tcctttaaac ggttccattc 5052 ctgctggtct tgaaagttga aatattttgg caccgctatg ctgtccataa tgcttcagaa 5058 tcaccaagtt ttctacggct tcgatggatt gctgcaatta atgattaatt ataattttac 5064 gagaatacac aagggtaatt tagaatgtga taagttgtgt atcgtaggtg aaaatgaaca 5070 agtatttgta acagacggtg ttaatatgga cgtaaggcgc gttgtccacg atgaatgctt 5076 tatcagcttc gaagcagtat ttgagattat tgatacaaac atgttaggcg acaagtatac 5082 cgtagagaag attattgtgg aatgtactaa gagagtagta aaaagtgacg tttggtataa 5088 aaaatatttg gtaatattaa aaaaacgcgt taacgcctct tttgatgtat actttaaagt 5094 attagaacag tatatgctgt taaatcaacc taatgctgaa cgaataggca aaaaggtctc 5100 taatctaatt aaaatggctg aagcgttaaa gcattccgac caagcccaag aactgataac 5106 tgcatatcaa tcttttgaaa cggcaagcgc tatcttacta aagcaattat aatagcagag 5112 ataactcgct ataaaaagat aaagggtata taatgttgat gtcgcattaa tttttattgt 5118 ttactcgttg ttgtgttaag cagtaaaatg tttccgactt ttgcaaaaaa aatagagaac 5124 acctcttcgg ctatagtgga ttcgctgtct ccctttcttc ccagcgaact gataattatg 5130 gtagcgtctc atattaattt gaaagtatac aacggagtga ataaaatatt atatataaat 5136 aaccaaccag aaaaaagtac tgttgggata atgataaaga gaaaagaaaa tatcgaatgg 5142 catttgcaac agcttaagat atctgatgag ctggaaataa aaggtggtaa aagaaatgtg 5148 agactaagtt tggagatgag acaatattcg tttgcaagtc ttcgagagat atttgaagat 5154 ttgtatcatg aagattttgc ggagctgaac aagagattca acgaagcggc taaaagactt 5160 ttgcgtgcca aagccgcgga cagcattgtt tttggtttta atatttgtct acagaacaat 5166 1308 SEQ.LISTING.txt atttttctta cggtttgtag atgtctgtat ggtctaccta ctggttggtt tatttacccc 5172 tttcaagatg gaatgttggt tcactttcga tctaatatgg tatcaaaaaa gtatttaaat 5178 tataaaatgt acaatgaaat gttttcatct ttagaagagt tttctgaaac atttggtcga 5184 tttattaata actataataa ttataaaacc gttttgagtg tatatggaag cgatgaaaag 5190 ttaaagagat acgtttgttc ttctaagtta tttaaaaaat ttatactgtt tactattact 5196 aaaaagctta atgttcgtca aattacatgt gctgaacaaa aagtcaatag agttatgtga 5202 ttttaacaat aaacaatgat cgaactcatt ttcctctttt atttattact ggtcagttta 5208 aaaatagcca tgacacaaca tgatgaagtt aagtgatgac gtatgtgtgc atgactcaac 5214 tgaccagagt atatatatat caaggtttta ataacaagaa gttagtctgc acagctatgg 5220 atcttaaaac actgttactt tttcaatgga acacgcctcc tacaaaaaac gtgcctcggc 5226 gttacgaata tacgccttca cgagtttatt attcgtttga aaacaccacc gcatatacga 5232 ccactggtat tcgtgcgtaa agagcgtctt tacactttcg caagaaactc gtgacttttt 5238 acaagtgttt aataatcgag cccagagaga cgactggtct tatattgaag tgagaaagct 5244 gcttcgggat gttgactata aagaaattga agagtgctat tgtctatggg cgtatgttac 5250 taaagacgga atgcccggct gcgaaagggt tatggaaaaa attattgaag attgcgccag 5256 cggtttggtg tttgtcaccg atgagtgtgt gacgcaggag actgacaaat atttgtggta 5262 ttgaaataaa ataaattggt tttaaaagtt aattgtttta ttctttagat aatctcacaa 5268 cttctctggc gttttcctta tacattttaa ggtagtggtt gcaactatac agattcataa 5274 catgactaaa tgcattaaag acatattcaa atattagtat atctttacaa cttaacgttt 5280 tatgatcagt tttttttgaa aaatatacag acaagtccat ggcttctctg ggatattttt 5286 taaatttatt acaataggtg tagaagaact taaaataaaa atcgtgttgt aaattttttc 5292 tgttctctct gtcgcgccgt ttccctctgt ctcggcttat catccaatgt gatccggtaa 5298 cgcgacagat aacatatggc cagcatgttt gtggattaat tttaacatgt aacactgtat 5304 cgcttattaa tgtttcgctg accggaaaca cagggggtgt tgtaacgact aaactgtcta 5310 1308 SEQ.LISTING.txt catcttcgta attaaagaga cctttatcta gcgcatcttc ataatcaata aagtttttat 5316 ctagcacatt tttgtaattt gtatagtttt tctccagtac tttaaataga gtgtaggccg 5322 ttgcagggtc gatcatattt agtggagatt tgtatcgctg ccgacattcg ccttcgagta 5328 aaactatttc acctttgtga caagtccaat tctgatactg agccgcaact tcttcgtaca 5334 gattaggttt acctatttgg gtaattaaat agttccacgc ggcccatttg gcgcttcttt 5340 ttttcaattc atctaaaagc ggcccgtttt ctggtgtgcg atacaagtcg tcgtatattg 5346 ccacaagctc gtttccaaag gtggatcgta gagggtttaa atcgcaattt ggcctttcta 5352 taggggctac gagaactgaa taccacaaac aaatctcaag aggtaatcga caagacaaca 5358 cattcttgtg tgttaaagaa atgtttgttt taaatctttt gcaaaaatta agaatttctt 5364 ccttgacggg cttctcgtag tcggtattca taaatttgtg tttgtacaac aaatacataa 5370 ctataaaatt ccacagaacc aaattgccgg gaactctgtt gttcggtcca aaaatggtag 5376 aaaaagctcg gcagttgttt ttcaatatat ctgtattatc acaagccatc acaaacaccc 5382 ctttgcacgc aactctggtg tgtggagaga ttaattcgta attgttattc ctctcctcta 5388 ataaagtgta tgtgctgtaa tttataaaat tattttcaaa aagcgatata acccattctg 5394 gtttcaactt taatggatga cgtaaaacat cgggatcggt cacgattgat tttactttct 5400 tcttttgcac aagcagacag ggacgtgtaa atttgtctaa cgtgattgta tcttcaaaat 5406 cgatccactc cggactttca taatcgtaga aactcaattt ctcttcgtgc ttgggtaact 5412 gtttaaacaa cagatccgag tttgtgtgat tgattcccaa gccgtcaaac attttaaaca 5418 attcgagtcg cttgttgtgt atgtttaaaa ttagacttct gctgttttga aaacgtttaa 5424 aaaattggct tctttcatct ttttgataaa gcttggttaa tatttcaatt tcttcggaaa 5430 cacattgctc tcaagatcat taagaacaga ctgcaatttt ttacgaaact cttccacctt 5436 ttcagatctg taaggttctt ttttgatggt ttgcaagtta agaatggtac tgacgggaat 5442 cgaagcgttc aaaagctctt cgtgttttaa atcgtctata ttttttaaag cttctgtgta 5448 aagttgttcg ttaacataat aagatacgtt gaggcaattg ttgaaaaaaa cgttgagccc 5454 1308 SEQ.LISTING.txt taaattcatc aagttttcgt caccaatgta ataaatttta acacttttag gtgtaaattt 5460 tctctcagaa agataaacac gcaccatttc aatgtcattg ttctttatct tcccgtccgt 5466 cgtaattata agatcaaagt ttttctcgaa tttcaagtac gaaaataaac acaccggaga 5472 acagtttcct tcgatttttt ttgaaaattc actctcctca gtcactgcat cgttccaaaa 5478 tactagcccg tttggtttgt acaagttgta aatgtctctg cactttagcc aataacaatt 5484 atcgctgtat acggaccaac cgttgtagac acacataata acacggtccg aattgaaaag 5490 aaattttgtt acaataccac ccattgtggt gcttgtttaa ccgaatgaca acaagcgtaa 5496 cgtacatttt tgcttttata cgcaaagaaa tgggtgacga atgatatcgt tgtatgtgtg 5502 tagccgttta gttatatcaa actgtagcat cctctgaaca aagtcattgg cgataggaga 5508 tgccgattta atccttggta attttcgtga cagatatgga agaagatttt gaggttcgat 5514 gccgttcata acatcgctgt tggtatcaaa gtcctttgtt tcatcttcat taattttgta 5520 gggataccgc ttcgaaagga tctcgtaggt caccacaccc accgcccacc aatcgaacga 5526 ttcctggttg acttcttctt ttattttttc cggtgaaaag taaacacttg tgccgtcata 5532 aagagagggt gttcctatga tgtgcgccaa gccgtaatcg gccacgtaaa ttctatgctt 5538 gttcacacta tacaacaggt tttccaattt aatgtcgttg tgtatgattt ttttcttatg 5544 aagttcgttg agggcattta caagctgtag tatgatcttt cggcacttgg tctcatcgaa 5550 tttgtaacga ctgtttttaa ccaaatcata caagtctcca tctttaatgt aatccatgac 5556 ccaaaatatg ctgtcgggca aaaagacggc cgtgtgtagc gatataaaat gagagttacc 5562 tctcataatg tcgtggacgt agagctctaa aaaattgaat ttttttctag aagccgtctt 5568 ttgtacgtac atttggtttg tatccttttt ttttaataaa taaatgttct cataagactc 5574 atcgtcactg tttaatttac ccacaacctc caagttttcc agatactgca ccgatttagt 5580 tatggatctg ttgggattca tcaggagtaa aaattttgag gcgagcgcta aagaagtaat 5586 aaatagattt aaatggaaca gcagtttaaa acgtaaatta gaacacacgt ctaacgatgg 5592 aaatattgta ttgaccgtta acgagttaga agaacttctc agtaccttat tgcaatttat 5598 1308 SEQ.LISTING.txt agaaacgcct aatatgcaaa ctgttccttc accgttacca cagacaacaa caacaacaac 5604 agccccgccg ccacctgtag ttgtttcgcg cccgtccccg cttatcggcc aaacggtaaa 5610 ctttaattgt aatggagaag aggagcgcat tacaaataca aggagaccca gtgatacgtt 5616 tagtagtaga gcttcaacat atagcacttt tgtagacgac acatcttcta ttcttatgcc 5622 tccacctccg ccgccgccgc cgcaccaaac gcttcccact tacggcgtac caaccgtcgt 5628 tgaagaaaaa acggataagg aatcaaatgt tgtggaaaat cttctttcta ttcttcctct 5634 ttcgattccg actcttcggt tgaggacgtg ccgctttcct ctaagctgcg gcaagcttta 5640 gaggaaagag aaaggcaaaa gcaattagtt aaagtaactg atgctgttac caccgataca 5646 gaggcttaat atgcgggtcc ggtaaacaga ggtacgtccg gagcgaactc tttaatctta 5652 aacagaagag aaacttcaat cataatttct tcaatttccg cggaagtggt gcccacgtat 5658 acgaggggcc tgtggaagta tggccatagg tgctcgtcaa agaagttctc aaagttgtcg 5664 ttgtatactg actgaagaca agttagaggg tatgcgtaac ccttctttga tagattaata 5670 cgttcaatgt tattgggtcc tacgtagtaa ggatcttgct gacggatcac gtcgtgagcg 5676 acgtaatctg gatgggcgcc gagcgcgtat tgcatggtga atctgtaaca acggttgggt 5682 tgcatggggc gaagctgaag ctcgaaccac aaatccataa tctcctgatc tgtggtgatg 5688 ggaaactctt ccgagataaa acgtgtccaa gtttcgcgaa ggaactcttt accgctccag 5694 ttgcagataa gtttcattgt gtcgggctga accctacgaa tctctttaaa cagcgtgatg 5700 cgaacattct ttcctggtcc gcggaaaggg tcctcggtca ccatgtattg attagcgaga 5706 tctttcaaag gtgcatattt agcttccgat atacgcctgt cctttttgtg aatatcgtca 5712 agaaccgaac ctaaactgta caagtgtttg ttatcaatta cacaagtagt accagcatga 5718 cggctgtaac ggagcgattt gttatatccc atattttgtc ttgttaaaat aaaaattcct 5724 tatagaacat cattttgttg ttttttagct aatgtaagaa agaacgtttt caagctttct 5730 acagatccgt tggagagtaa cgaatttaca ttacctatca ccgtcattat tgtgtcgtaa 5736 ttctctctca acagatgagc attgtttatt aaaaatcgta tcaaatcttg atgatcacga 5742 1308 SEQ.LISTING.txt ccatccatca gcctagctac tatttctttt aaaccgctcc ccactgtgtt gtcatcgtag 5748 ctgtttgcgt ttctctcaca cgttcgaacg cttataaaat ctattgacac tccccttttc 5754 tcttccgcgt ctcttctaaa ctccattatt aattgctctc tcgacgtcat gttataaaaa 5760 tgacacttct ttattgttta taatagacga taagcgtcat cctttacatt aacgataaca 5766 acctatatat atataagctt gttgtgctgt catcaacaac ataattactt acaatgttgc 5772 tacaaaaggt tgtgtgcgct tcaagaaagg agggagaggg gaaaatagct gtttacgttg 5778 tgacgggcga taatcaaata tattactgta aagaaacgtt cactcaacac cttaaagaca 5784 atgtgggact gattgaaaca aaatacgtga aacgattcga tcaatttgaa gaccttatgt 5790 ttcaagtaaa cgtgcatata gacgctgatg ccgaatttat caacgaaccg ggtgtgtatc 5796 aattgttgtt gggtggagga caattgggca atttggaaac caataaggat tttatagact 5802 gggtctttaa agaactttta cccactgtaa agatgacggt tttcttcaga aacaacactg 5808 ccaccataga cacggtgccg ttcaataatc atctttgcat ggacaactta attgcaatta 5814 taaaacaacg cgacgcgctt gtcgctaaaa aagataaaca aattgatgcg atgctgaata 5820 cggttcaaca acaactaata ttgttgagtg caataagaga cgtgaacaaa acacgttttg 5826 atcaaataga tagcaccatt gcaaagatgg gacaaagtgt gcagcaaaag attgccgagt 5832 taaaattatt agttctcaat gcgccaatca agtaatagaa attgttgatg atgacgaaga 5838 ggagaatcaa attcatttac aagagactca aataatacct gatcttcatt tgatggacac 5844 gcaaatcata ccttcggcgg tggcagagtc gcaagaaaag tttataaatt atgaagagaa 5850 gaacgaaaat agccaaccgg cggctgagag ctcaccatcc attttgagat cacaagattc 5856 gctgccgcca aattatgaaa tatataatga actggataaa tggtacgaga ttacgagtca 5862 aacaaattta gcaagtcaaa tgacgagtcg tacggataac agaaagttta tagaaaagcg 5868 taacaagacg tcctcccgat acggagttct tttgtacagg gaagatggtg ctgcgattgc 5874 cgctgtgatg ggtcaaatgc actatgtgtt ggcgcaaatg aaaaataaaa atcatatcgc 5880 taacaatctg attgtgttgt tctgcgtaga ggatccgcaa aagcattggt tgttaattag 5886 1308 SEQ.LISTING.txt acaattaatg ttaagcgagg gaagatttat acaccgcatg actaacagaa aaatttattt 5892 tagtactgtc actgaagccg acgagtttga aaatttgata aagtgcaagt ttccagaaca 5898 acaaataaag atgattgtgt aattcaatga gttaataatc tttaaataaa cgcttacgca 5904 ttcttatcaa cttgtttttg tatataaacg accttacatt aagtttgagg acattcgttc 5910 gaggaaagtc gttgttattt ggtcttttcg acatggttta cattaagatt gatattggta 5916 gtcacacaaa ggggtattcc accaatacta gcgaccgtga ttatataatt ttttcaaaat 5922 gtgacgctta tacttttttg gaccatatct ctgagaaaaa aaggctggtc aacgttcaca 5928 aaaaagacga agaagggaat gattgcgttt acgtggatct atacaaaggt ttacaaggta 5934 tttacactgg caaatattat tacttaggtg tatttgcaaa gcagagtgat gttaaagaca 5940 aaaatggttg ggaaaatgtg aacttgtttg aatttattca agacctaacc aagctgcgta 5946 tacatttgat tttgaaaacg atggtaaaat atagagtaaa aacttccctg accgatcaac 5952 ccaagcaact gttggccatt atgtttaatt tggcctacat tgaacattgg ttaaagtata 5958 atacatttcc tgaggtcaac aaattgccaa atttattgta cgatgaagaa aaacctctgc 5964 gctactacaa gagtttgatg aaagcgcgcg ttgagaacac tgtaactaca ctttccgaag 5970 aggttgatta cattaaaaat tggcaagatg cggtagaggt aaaattagag tcgttcggca 5976 cacccctgga gagatatgat attcaaagga acattgtaat gtacatgtta aatgcgggta 5982 gtctacaggg tttttgtgaa gataccatca aaaactgcat ctttccatcg attcaacagc 5988 tgtcgagaac gaagaatggt aaccttttcg gaaggactgt gactgtccag gaaaaattgg 5994 acgggtgcaa ttttagagtt atagtcgatc gggacctaat cacgtatggc tcaaggaaca 6000 cctattattc tactcgtgat ttcatggggt tttatagaat taaaaactct ttggaaaaat 6006 ctgccataaa gttgaaagga atactaaagt taaatcagtt tgttatttac ggcgagctga 6012 ttggttggtg tttttcaaat gataaactat tgtatgagac aatcggacaa gagatcgatt 6018 acaaactacc atacggcacc ataaagtatt atgcttatga aattcgtaaa tacgacggct 6024 acaacaacga ttttttggac tttgaaatga gccaaaaatg gctgcaggag gctggttttg 6030 1308 SEQ.LISTING.txt atatcatacc ctatgataaa atcttttatg attacttcat tgaaatatca agttttcttc 6036 caagcttttt tctcaaaact ccattgaagg ttatataatt cgctgtggtc ctctgagata 6042 taaagtaaaa gaacattatt gtttgggaga tttacgaaac gctttacatc agattaataa 6048 tacatttgtt aatagcgtat taggagagga agagggtaaa ttggaattac acgagcttgt 6054 atttgccgca aaaaaatgtt acgacacgct gatgcctgtc gataaggata taccgctcta 6060 taaaattttt ggtaaactct acactttatt gagacagaga gctcacatta ctgatgattt 6066 gcattactcc aaagcgtttg aaatgtttca aactttatta gaataatgtt ttacttgtga 6072 ttaaaaatta tttgaataat tgaaacaaca ttgttttatt tatcaaatat atttgtgtta 6078 tatagcataa ggttaacatt gtgatatttt cctttaaata cagtcttcca aaacactttg 6084 ttgtaattgt atttttcttt ccaaaatggc acaatcctca tgtttttatt gcgtcgccaa 6090 taattggggt cggtgaaacc acaagtgctg cacgagagta tgggtaggtg gttgtgaatt 6096 ttacctcgac aatgaccgca ttcgtatatg gtaaaatgat taaaatagac agtgaaaggc 6102 tgatattttt caaaaactct gtagtggacc tcaatgaaat aataatcgtt ttcgagcctt 6108 ttatcaatct cagaaattag tgttggactt aaggagagcg gagtgtcaaa gttgtattca 6114 gtaccgttgt ctacgcgtaa atcataaatg acatctcgtg ccacgacagc ttgtcttccg 6120 cgccacagct ccattacttc aatttcttca tttgaatctt tctcctctac aatgtccttt 6126 agcacctgcg ctatagatgt tccgccgacc aaagcgtgtt ttctaaattt cttttcacca 6132 ctttctttaa agtcaaacac aaacttcttt aatagattat tgtacatcag ttttttaatg 6138 ttgtgtaatg ataatgtcgg acttatttcc acaacatcca tcatttttaa ttctctacag 6144 caatccaagc agcaaaattt aacgtcttcc tcttctacgc tcaaccaatt ttttattact 6150 acaaaaatgt atgggctttt ggttttcaca aaaatttcct tgaaactttt tttacactta 6156 aagcaaggtg gtgtaaactt taaaacattt aaccctcctt gaatcattgt attcgttaat 6162 gttattaaaa aattaattac ttctttagtt tcgttagcca agaacatcac tcttctatcc 6168 tccataacga atcaaaacaa aatcatacac atgtttatta cacactttta tttatattcg 6174 1308 SEQ.LISTING.txt taaaaagtga ggtaaccatc atgatgatac aaattctcaa aattgattaa acgtcttctt 6180 cgtcactgaa ccgcaacgga tcgctgatat tatctctcat aacttcccga agttcgttta 6186 aaaatatatt cttttcaatg agcgatatgt caaagttcca agttttgtaa gaaaaaacgt 6192 attcataacc cgttcctatt cggtatccat caaaggtcaa ggggaggggt acttccgaag 6198 gaattaaata ataatagatg tactttaaaa acgagttgcg ccatctgttt ggtaaaaatt 6204 ccggacccca cagatacatg atcggtttct tgtattcgtc aggaagaaat gatgtattat 6210 aataatttaa catcactgcg taaagacaga gtcgaggcgc tttcgaaaaa ccaccaccgt 6216 gtgcgttata aatcacatcc cagtcttgta tattgcaagc gccgaatcct ttgagggtaa 6222 actcttttaa acgagttaaa accgagtcca ccacgaccaa cgataaaaga ttaatttctt 6228 tttttaataa taacgttttg ttactcgttg aaattaattc agcgtgccgc tctacggcgg 6234 cttccagaac cgattcatct ttattactga cacgcgaggc ggtgcggtga cttctcgaac 6240 tactctcatc gctaaaaata gaataatgat ttcacagtta aagaactata taaacgttac 6246 aaataggaca agacctcatt cgtgttcgta acctcattta attcgctgta gcaatgtctc 6252 tcgttgtgct atcgctgttg gtatcgggcg ggtcgtgtgc aaacattctt ggggtttttc 6258 caacgccgtc gtatagtcac caatcagtgt ttgcggctta tgtcgataag cttgccgccg 6264 ccgggcacaa cgtgactgtg ataacaccta tgaaacgtgc gacaggtcac gtacgcgaaa 6270 ttgattgctc tttatcggtg gaacgtttcc aagaattagt aagccgttca aaacatatta 6276 aaaaacgagg agcggttgct gatgagttta ctgttactaa ggaaaattat atgggtttaa 6282 ttaatgtggt tgcgacgcag ctagaaacta acgccgtgac tgcgcttatt aaaaaccctt 6288 tcaacaaatt tgatttggtg gtttgtgaag cgtatttggc ttacacatta atttttggcc 6294 atatttatga tgcacccgtg atccagcttt cttcgggtca tggaattccg gaaaactttg 6300 aaatacaagg cgccatagcg agagattacg ttaaccatcc taacatatgg cgttctacct 6306 ttactggatc gccgctggag caaatgttta tggaaaacta tctgaagaac gaatggggat 6312 tgattgaaat tgaacaggaa aagatgttac gtaaacgttt tggatatcac ataaaaatgg 6318 1308 SEQ.LISTING.txt aaaacctaaa aaaatcggtc cttatgctgt ttataaatgt gcccgctgtg tacgataact 6324 ttaggcccgt caccccaaca gtgcagtatt tgggaggttt gcatctacga aaagaacaac 6330 cgattcgaga tttggtccta aaccgttttt tagaatcaca ctctacgatt gtgtacgcga 6336 gttttggtag cgggatagat gtgctggaca tggatagaag cttactaaag gagttgatac 6342 gtgtttttag taagcttcct tatggaattc tgtggaaagt cgacgactct gttcacagca 6348 tatataacgt tagtgctaat gtatacacaa aatcttggtt tcctcaaagg gatttattga 6354 agcatgagaa cgttaaggcg tttataacac aggcgggtgt tcaatcggcc gatgaagcga 6360 tcgatggcgg cgtacctatg attacactac ccatgatggg agatcagttt tataatgcgc 6366 accgcttcga acaattggga attggaatac acttagatgt attgaagctg gaaaaggaaa 6372 ggttggataa aaagattgtt caggtggttg aaaatagaaa ttataaaaag aatattgaac 6378 gtttgagaca ttttattaac gatgtaccac tgaagtcgct acgcaaatcg ctttggtata 6384 caaattatgt catacgaaaa caaaaaacat taaatgtaat taaaaatgta aagtgtaatt 6390 aaaaatgtaa agtaaaattt aaactacact cctgtgtttt cttttataat gcaaataact 6396 gcttaatcca aacactaatc ctaccattac gatcactact gtacatgaaa ctaccaataa 6402 gggaagattc atagccgctg tctgagccac cgctgctgct tcgctgtcgt ctgaatacat 6408 catttcgttg tcgccaagac aaatctcccc gttcatatcg tcaaacatat tagtaagagg 6414 atacgtttta ttgctaatta ttgaagcgct ataaacttcg gcattgttca aaaacgtaaa 6420 gcggtcatag tccaaattaa tagtgcacaa attatcattt attcgctttt tccacacgat 6426 ggtatcgtat tctttttcct cttccaccag tgaccaaaca aagatacaat cctgattgag 6432 ttttgaagac atgtaaaaat gagcgcagtg tgtcatacaa atatatttaa agacatctca 6438 tgccttaaaa cgattctgtc tttatcctca ccttcgctgt tattaatatt gtattggata 6444 atattaagaa atctgtttgg cttagccgtg taacttatgt acattcccaa ctcgctatta 6450 ctggcgtcca agtaaacacg ttggtttttg aactttttaa acaattgcac cattttttga 6456 gtagcctcta acttttcccc taaatctgga cttgtatcat ctttttcgat ctttgtagaa 6462 1308 SEQ.LISTING.txt ataatttttt tttccggcgg tctaacagtt gttgttgtag tggtagtggt gctggtggta 6468 gtgcgttttt cgccagtttc tacaaaatct tttttggttt tcgaatccgt tttcgtcgaa 6474 tcaactgcaa tctccgaatc accagaacct tctgttaaac atgaagcgaa caccacgagc 6480 gtaattagta tgtatagtgt tacaaagttc ataatagttt cgcaatgttc tcagagagta 6486 aaacatataa gtgataaaaa tctatttgta tacgtaatta agatatgcga aaccggcgaa 6492 cgttatcagt atcgcaacaa aaagcaatgc gtcgtaaaat gtatttttca cagtagtatc 6498 aacagaacag caacacatta cacttttatt atcgtctttt gtaaacgata ctggtttctc 6504 tagtgtatca aaattgtttg agaccagcgt cacgcctatc agttcatcgt gtctccgagt 6510 tgatgccgac gggtaaccaa aaaatctttt aaaaaacttt ttcacgtccc cctcggcatc 6516 attaccaaaa agattctcgt taacatcgta agttttacaa tttatttctg ttgtacttaa 6522 atatatttct ttgtttcgct ctcctataca gcatttcatt cctttactct ttgtacttta 6528 cccgaaagcg ggtttgaagt gtcttttata aattcgtcac taaagttgta agataccgct 6534 attattgcta gtacggctac cagcactaaa ataaccatct tccaactgaa tctactaaaa 6540 aaacccatat tagtctggtt gaagcgcgtc aagttttcca tgtttgcgtt tcttttttgt 6546 tatgtatggt gaccgcgcct ctgtcaatct ttatacactt tttaattctt atcaacacgt 6552 tattcgtcgg ggaaaaagta gtttcgaaac tcactttgaa acatttgcca atctcttact 6558 accgtatcgt tttgtttgga gtcgcgcaaa atgagatcta tgtagcgttt gtaattattg 6564 ggattatgtg tccattttgc atagtggtag atgcgcttca ccatatcttt aggcggacac 6570 atgatatgac ccacgttgat gctgtttcca aacttgagct cgcaaatttt gatgtacgat 6576 ttcttacccc cctcaatacc tctattacaa gtaccgacgt tttctataat ttttgaaatt 6582 accttttttt tatcattaaa aggatttttt tcttgtagca acatagttag aaccgtattg 6588 tatgttaaaa aggatttata aatgtcttgc gacgccgttg cttcggtaaa ttctggaagc 6594 gatgaaaaag taaatatttt gtttagatgc ggctcttctc cttctttata aatacaatac 6600 atttcttgcg gtagaattat gcattgtatg tccgaataca aacaatccac gtacattgat 6606 1308 SEQ.LISTING.txt ttgagaagca cataagtttt gttcccgtct ctcgcggatg cgtctctcgc gttaccgttt 6612 aggtctgttc ggtcgttgtt taaaaacttg tatacgcttt tcaacacaag tttcacgcta 6618 gacatatttc tttcacccgc ttccttgata ctgcccaatt tttctccgtg tacttcaaaa 6624 aatttggctc cacaaatgag ggacgtgttg acgagtaaat gccttctgtc gacgttctct 6630 tctccgctga gaagccattg aaaatacggc attcccgtta ccgaggcaaa gcgagtgtct 6636 atttcagagt agtgttcata aacacctttt ctcttcccat tattcgaatc agacgacagg 6642 tcgctgaatt tggatgaaac cgacaccgac tctttgaaat cactataggt tggaagggta 6648 tcgatcgtac cgtagcatgt tgtgaagaca gcattttcgg tcggtgaaat tacgtagaat 6654 ataagatatt tattgtcaat tatacacacg ttattcttta gtatatgatc agtgacttct 6660 gacatgtcgg catacaacaa tattgttttt attaacgctt ctgataaatt ggtgaatgat 6666 agttacaggt acgttaggat ggacggtagt ttgtacgtat atcagaacgt atatacgaaa 6672 gatgaaataa aacttagtta taaactgtct aaacataacg acaccaacac ttacgccgtt 6678 tactattaag aatgagtaaa aaagaaagac gcgcctcttt aatgtacaat ttcaacattg 6684 aaaatttgcg cgaaaaaatt cgaagccgca ccagcagtaa gaataaggag gagcggtctg 6690 ttacaatgga tgaaaataga aacactctag atttagacat ttcaccacaa ccgggaccta 6696 gcagcgccac agtagacccc gttccattgg ccactttatc ttacagggac accgaacacg 6702 actacagttt agcaccacct tccggaccca tagtggaacc gcctccgact atacccgatg 6708 atttcgggga aacacagcat tatcctatga ccgttgaaga ggcaaaaaat tttgatgccg 6714 ttaacgcagt attaagagag agggacgtct ttgaattgga gtcttacgtg aagcgagctc 6720 tggcgcccac catcaccgtt gacggtcaac ccatcgaccc ctccaaggtt tttgtagcga 6726 aagctcctca tttacccgaa aatagagatt tggcaatggt gcagctcatc gcgacatctt 6732 acatcaacga aattatgggt ttgaacgaaa cggtgtatac gtttgtgcaa agcagcgccg 6738 gagaccgcgc tgtggggtac ctgtattttg ccagactttt atacgaaaac ggtctaaaca 6744 ccaatgtacc ggccttttta aagtgctgcg atgctatgag agccatgtac aacagttggg 6750 1308 SEQ.LISTING.txt cggatcaagt agaaagattg tttccattga ttttaaattt aaacggattt gatgttgtta 6756 aagaaacgat gaatatagta aatcagagcg tgtaccgttt ggtcacgttt gtgctggcat 6762 ctgaaggtgt tagttcccca aaactttttt accgtacggc attacgaaac gcttccgacg 6768 tctacgatgg tagagatgag ctagaaacga ggataatacg agaccagcag ctgttaacta 6774 atttgtatga cgagcggttt tttaacgctt ctaaagcgaa aaatgtgtat aaattttaca 6780 aggaagaaaa ggaaacgccc actttcaatc ttggtcatat taaactttat aaactaaagg 6786 tggctcctca tcagtttaac aaatttgaaa ttatgcgaac gttataatgt agtttatgac 6792 attaatcact aaataaaaaa tgttgaaact tatatttttt gttgtataat gacactctct 6798 ctactatgtg tactatttat tatttccgct tcaaccaccg acatcacatt taaatccaca 6804 ctcgaagcgt acactatcga cggacgaggt ttgtgtattg gcgattgtgt tttaaccaaa 6810 agcgaagaga gatgtatatt taaatataat atggccacaa cacagtgttc ttcgtccaat 6816 aaacccacca aacgttaccg tacattatat aatagaccct gttatagtaa ctgcgattat 6822 ttcgaaaacg aatactacag ttggtgcgtc gagaagagag acaacaactt tagatgggat 6828 tattgtacca gaaatattgc gcttaaaggt aaagaagtta ttaggacaga taataagtat 6834 atgacatgcg gttatactac atgtggaaaa cataattatt ttacgtacaa tggtgcggta 6840 ccataggaac atattgggaa tattgtaatc cggccaataa agtaattctg tttgaataca 6846 cgactgatgt aaacaccaaa tgtgcatccc cttgtgagat ggatcgcaac aacgtaggtt 6852 attgttacga catcaactac agatggtcta attgttactt gaatccagac ttttcaaata 6858 cactagaaga cgttcatacg gcatggttgg cgcaatataa tacgggcggt atatacactt 6864 tagacaaaga atatttgtta tgtgatagac cacaagatgt taagggtgtt gaagatagaa 6870 ataaagaaga agctcataat aaaattttta atcactttcc gccccgtctt ggtttaagta 6876 tccacagatc gtattcgact gtgcaagatg tagtggatct ttatagaaaa aataatccga 6882 cggtatattt gcgccaccct gatgtggacc cctcggcgaa caataatagc aatccggtcc 6888 tctactacac agtcagtcca gttccaaatc gaattggcga agatcaattt aatctccctt 6894 1308 SEQ.LISTING.txt tagttgtgca cgcgataata acaaattaca ctctaacaaa taaaatggtg ttgttcagta 6900 cagccacgcc ttcaatacac cgctacatga acaagatgga tattacggat ttcgacgaac 6906 cttcctatat aattggcact cgtctcggcg gctcttcgaa gctatacaat atgtttccta 6912 gaccttctaa ttatcttaca catgaagaaa accagtggca cgatttagaa gagaaaatta 6918 taaatttttt gaagagcaaa aacaagcgtt atgtggagta ttgggccgtt ctaacttata 6924 ctaagtcttc gtttcgcccc tcttttgtcg gtgtttgtgt aagactttat gaagataacg 6930 attttgtaaa ctttgacggt aaatccatta caattgccac caatccttta gaaaatatgc 6936 atttcactaa tgagcgcacc cctcacaaat gtagattata gtttcaagtc aaaatcgtat 6942 tcaatatcgg tatacctctc ttccgagcag cgctttacgt tgttttcaaa caatttaatt 6948 ttctcctcat taccttcatt taacacgaaa cgtttgctta accttacaaa acttttcgcc 6954 gcttcatcgt tgacaaatgg aaattcaaac ttaaaagcta tggggcgctt gtagggatct 6960 tgcctgcgga attttttagc gcaatctgca caaaaaatat gttccaaatc cgctttaccg 6966 tcgcacgtaa tgtacacaca tcctttattc ttttcgtcta ttatatcata acaaacggca 6972 cattccatac tgggaaattg atcaaaaata atttgttcga ttcctcgttt agtaatgtcc 6978 ttttctttaa ctgtcaaaac aaacataatg atgttggtct ttttatataa taccgctacc 6984 gttttttgtg cacctctaat aaataatgca gattataata taacggcgtt aataatcagc 6990 gggctgaatt gttttctgca atttgtggag gtaatgtttt taatatgctt agctatagga 6996 aaaatacgca acagatagtt tttataaaca tttattctct ttcaattatc ttgtcaaaca 7002 ctatcatgac tgtgaagcac aaattacatc caccgccgat gttgaggtgt atatcttgca 7008 actgttcggt ctctttgtcc atcttaaatt gaagcactcc gtctttattt tgcgttgccg 7014 ttatgcttga aaagttgttt tcattggaac acttcgttgt taacacgcct tgaaacggat 7020 gatcattttt tttcaatccg cttacctcga tgtatctcac agagtctgta agagaagctg 7026 ccgcaaatcg tagtactatc aggccgtggt ttatttccat tcggtttaat ttgaacgcct 7032 ttttaccgcc caccttgacg tgtatgtttt gtaattgttc aaccgacatt tttctcagtt 7038 1308 SEQ.LISTING.txt tgtcgcttga agatttcttg aggttgatat actttcagaa atacatttat ttacattcgt 7044 tactgtaaga ttaacatgca tatctttgta atagctctag ttgtcatcat aatagtagcc 7050 atattgtccg tcgtgcttat cagtggcagt gattatttgg aagatgataa aaaaaaagac 7056 gaaacagacg atgaagagac ggacaacgaa gagacagaca ctgaagagat agaggatctt 7062 ttaaactgta atgaattcta ttacggaaac ggtctagtcg gaacgtgtcc agaactacag 7068 gaatataata aacttactaa gagatgcgag catctttccg acaacggttg tgtggctgag 7074 cgaagaagct taaaaacggt cgatgttata ggtgattttg cttgtaacga aacggttcga 7080 tggaggcgag acataaaaag accttgccaa cttttaatta attgtgacaa cgataacatt 7086 gtgtttgcaa ctctcgagag ttattgttgg gaaagaagag ggaacgagta tgtggctata 7092 aggtgtatat tggtgaatgg atgtcgtaac tttgactctg tacatatcaa ttaccaaatt 7098 tcatcggatc cgcaaacggc cgatcccgaa acaacaaatt gcactagaga gtatcgtaca 7104 gagccttatg tgaacgcaaa ccagccgtgt ttgagtcttt ttagatgtca gagtgacgtt 7110 cagaatgggg cggtcgatat tttatggtgc gacaaatgta taaaccatcg catagacttt 7116 acatgtggtc aatgcaccca gcgacgctgt gcttatttga acaatttatg cccaatggaa 7122 aacgttgctc gcaaattgga aagaagttta acacgagact ttcttttaaa catagctaaa 7128 actgtggaga cgtgcaaaac atctaaaatt gaagagataa atgatctaga cacacctctt 7134 ttaatgttag attagcttat gggtgtgcta gatgacttta attctttata cgatttactg 7140 cgctcttata accttgaatt tcatctttca tgtcaaaatc tcgacaagac gacttcgttg 7146 agacagctgc aagataaaaa aacttatttt tgttgtggaa taagtaaaga attgaaaaag 7152 tgcgttttgc acaattgcat agttgtggtc atagggaccc tattggacaa agagtttagg 7158 tgtcatgagg atgattatgg ttttgcggga acatttataa tagacgggcg tcatttttct 7164 tttcccaata taatgatgaa taacaatgtt ttattgcata atttttttga caaacaatat 7170 gcgcgagaca aaaacatgcg ccgcatgttc ctttacggaa actttgacga cgaaaagtcg 7176 gtaaacagag ccattcagtt agtttatgat cgtaaagagg acgtcttgta tgtcagagat 7182 1308 SEQ.LISTING.txt gtgtatgcga aagattacat tgtggatgac ggtattaatg aggtgctaaa agaatattta 7188 aaatgtagtg gtaaatggca tgagatggat tttgtctttg attttgaaga ttatgacgag 7194 atatttaata gcttaaaaca aattatgagt gtagacatag attatcaaat agattctctt 7200 tcaaacaaaa taatatataa acactcatat ttacttctgt tgacatacag cagtctcttg 7206 aacaaaatta aaaatttgac agaaaatggg ttgggtgtac gaaagaagaa attgaacatg 7212 ggtatacttt ttcctttaga gtcaaagaag tgtagcgaca caataatttc gggaagactc 7218 attcagtctg tatctaaaac gctaagtaaa cagcgtaaaa acgatcaaga gtacaattca 7224 aataacaata atctcgaaat atttcctcta caacatcgca tcggtaatga ggtgttaaga 7230 ataatcaatg agaaccttca acaagatatg ttaaagcaca cctccgactt tgtaaaattt 7236 gttgatagtt ttttccacgg agaaatgacg gtggctggaa agaagttttt tcttgtcaca 7242 atgttgtttt acccgatgtt aattataaga gagcgagtgc tctttttaga cagctcattg 7248 aagaaaagtt tttcttcgca aaaaatgatg ctaacggcgg gtctcagaaa agttttgaaa 7254 cttatttcga gctacaaggc gacattaaca ataagaaagt cttaaactat gctaaagagg 7260 cccctcttgt atatttagtt tcttttaata acagacctac aaaatattat tgtaaaagaa 7266 gcgatttata ttgtgtttat tatatattaa agagaaacta ctctccgata gagatcaaag 7272 tttctaacgg gattctattc gttaatcatc acgaaggtat ggtaatgtta aaaaagttgg 7278 tgcgtatcca tggtacgacc ataataaata ctatacaaac accatacgaa taccacaaca 7284 agaattctgt agttgctagc agcaataaca ttttggaatt ttatcaagaa aatctttcca 7290 caacatcatg cctcatgagc acaatggtat taaattatta caaagattac ttgcacatct 7296 ttaacactat tcccgtcgcc aagttgattg tgagcttgac taatctcaaa aacggtatgg 7302 ttgtgcatac tttagataat caaaacgtta tacaaccgct gggaaatagt gttagagtgg 7308 acccttcaat atatcataac gatcgaatgt tcattctatg gactttaatt cgagacagcg 7314 gtttgaagac ggccgaagat ccgtacatac cgcacaattc attaccgata cgcatctttc 7320 ataataaaat gaataaagtg aaaggtaaat tagactgttg tggaccatac gaaaacgttt 7326 1308 SEQ.LISTING.txt taattgaata taaagcaagt tcgcacaaca atattataga cgtggaggga tggaatcgac 7332 tatgtttgtt tggaactctg gtgtgcggtg ttaaaatgaa ttggaactac gatggaaaaa 7338 aatataaaat agaatattgt ccaagtaaaa gctatcatgt atacaaattt tatatgtatt 7344 ttaggaaggt gaagggacaa aaagtggaga ctgtaaacag cgaaatgttt tacaacgacg 7350 acggaaccgt gactgtaaaa ttgacgcttg tatatagcgt ttctgatttg gaaggtttaa 7356 aaatttgcgg tgtgcacggt caaaagggga ttttgaacag ttcggaagat ttgtctcgtt 7362 ttaaggcgga tagcgattct tcaatacatg ctcaaatttg tctctcaccc atctcgtata 7368 tatcgcgcca aacaaacatg gtgggaatga gaacagaaaa gtgcactatc gatggtaaat 7374 gttatcctct cgttctgatt ccgtatatgt tttttaacaa cacccctgat aatatatata 7380 aagagtttat cggaaaaaat attacaggat atgaaaaatt agaaggcact cgtttggacc 7386 aatggagtat taatcaatct tttatgggta atcgcctagc ggaaggtctt cattgtgtac 7392 gaaacggtac taacacaccg cacccttcgg gtcaatacaa tatattcaaa agtcttatcc 7398 attgtaataa tattagtatt tctacatgaa gagataacat cttgagataa caacatgaag 7404 agataacatc ttgagataac aagtatataa tacacggcgc gcttttaccg tcatcatcag 7410 tctccgactt ggtccgttct ttctaacaca tatttaatta aatacaatgg aagcagacat 7416 tagcagggac tatacaaaat attgttttaa aaatgatcgt ttcaatgaag ctgataaaat 7422 aatacatgtc cacataaaag atgcgttgag agatattgcg aagacgttag cggttttgga 7428 agatttggtg tacgtttacg gctttagcgt gtgtattgga gttaattttg tcgatgacga 7434 tatttatgaa agcgatgtgt ttcgtcttgt gaacacttta aaacatcttc ccgtgaatat 7440 aaatcgctat gagacgtttc cgacaacaag tttttggtgg atgtggacga ttacgacgaa 7446 acaaactggt gcctattaag aagaaagtgg aaaattgcca aactggaatt agagctgaag 7452 aaaaaaaatg atccaaaaat taaagctgct ttgctacaac ttaaagccca agtttcatcg 7458 gaatacgtga ttaacttgta tattcataat tattattatt atttattaca acatgacaat 7464 taaaatgtga catgtgaaaa cgttttttat ttggtgtata aacgtttctc tctaacctct 7470 1308 SEQ.LISTING.txt gctacgagaa aatgatatgt aaaagtatta tattaatcat gtttttatct aaaacatatg 7476 gagcatttcc tcccgaaacg tttttgggaa caaaaaatgg tctcatgcaa gctaaagcgc 7482 aaacatatga agtgatacta aaaatagata aacagtatgt atctcatgtt ccaaaaaaat 7488 ctggtaacag actctatcta agcacaacct ctttttctcc tttaataatg tacgtcatta 7494 aagacggtta tgtctttaga aatgccaaat acaatgatat tctttgctat atggaataca 7500 acggttttcg tatgctatcc tttcctaaag acagatatat gccccaaagt tgtatttttt 7506 atatggaaat cattagcggc ggtgaagaaa aaaaagagtt ggagtataaa ttaaacaaag 7512 aaaaagagct atgcattctc tcctctgaca ttactgcgta taatcagcaa aagttatatg 7518 tcaaaataaa caatgtgaaa agatatctta caattgacga gaaaggaatg aaaaatgaaa 7524 aagatggatc aatatttagc ttcagttaca ccgactgttt gactagtgta gaggagagaa 7530 actataattt tatttgccgc attttaagac gtggcggaca gtattgtgct gaaggagacc 7536 gattcgtggc cgaccatttt cgatggaaaa aagaattgat cgacaatctt gcggaaacct 7542 cttttactga cactacaact actttttatg aagataatag tactagtaca actgtttttt 7548 cagtagatgc tcaccaaact ccttcttcta catatttttg gtgcgattat gtggacatgt 7554 tttgtagtaa tagtagtgta agggtaacaa atacaaaaac cttgttaata atattaattt 7560 ttattttgtt taattaaaaa tactttcttt atataaaact gtttcttctt ccggctcctc 7566 ttcagtaaat tgaaatttaa tttgttcttc gtacacttta tcaacctctc tcatgttttt 7572 gatggaattt gctggtatgg gatcgacgag tattaaaccg tcgcaatggg tagctctgct 7578 gagggccacg taagcttgac cggctacaaa cgtttttgct ggatacacaa ttaaattacg 7584 taaagtcata ccctgagctt tatgtatagt aaccgcccaa ccatatgtta tgggaagacc 7590 gtaaacggtt ttgaggacgt ttttatcttc tgtttcaaac aacactccgt gcattgttaa 7596 ttttcgttct gttccatccc attctctttt gattgttaaa cattcgtcgc tcacctgcac 7602 tatagttcct atatcaccat tacaaaaaga gttttcgccc acaaaatctc gaacgttgag 7608 agttatcatc acgcgtgttc ccacgcaata ctttatatta tctttaaata tcatctcctc 7614 1308 SEQ.LISTING.txt ttgactttta ttgtacggca ttgaagtggt gtgtcgtttt tcaagcgttt tgattaactt 7620 gacttgatat tcctttttgt ctttactttt actttttaca tactcatagc atatgttatt 7626 taaatgattc gcttctaggt gtgtgctgac gagactggta caattgattt tttcctctaa 7632 acacggttcc tgatcgatca ctttagagtt gaaaaagtct tgacaagacg cgtctccctt 7638 tcgtaacaaa tttagggctt taataaataa ttcttcagat tgtctcatgt ttataggaga 7644 ttgaacaagc gaaaatctga ccacgcatga gaatggtatg gtggtaaagt gaaattttgt 7650 cgaaatctgt tctccactgg tggtagctgg tataaatctc caaaaactat tgtgttcacc 7656 cctccaaatg ccgcatcttc tccagtgctt cttttaagtt gagcgtcgat tccgtttaac 7662 attttagcag gcaccatact aatctcatca attatcagga attccggtgc gttaatacga 7668 taattactga tgtttaaatt aaaatcaaat ttaaacattg aatgaatcgt ttttccttct 7674 atgtttcggg cggccaaatt ggtgtaggag actatccaca caactttctt ttctgcacga 7680 caccaatctc ttatggcgat taacaatgca ctttttcctg tgccagcgga tccggacaca 7686 aagattggag caaacttttt aactcttgtc acataatcgt atatcctttg ttgttcttca 7692 ttcaattttt ttggcacgta aagtctggaa gacgactgtt tttgcttttt gttgttactc 7698 tcgactaaat ccaacagctc gtcaattgct cgtttctccg ccatttttgt cacacttttg 7704 cgaatgcttg tcaatttcgc cacagcaaaa taactttaat gtgttatcgc tagggtcgta 7710 aaaaaatcct tgatttgcca actctataca ctgttgataa tcataagaac agtatttatt 7716 taagttatta accctgtctt tttggtttat ataattgaaa aatttaatgt ccacgtgact 7722 gatattatct gttttatcac agttgctatg tgtcatttct agaaaaggtg ttgatgtttc 7728 gtatttgctt ttacaaaagt aacaaacaac acatccttga ttataataaa agccctgacg 7734 agccaacagt ttagattttt cttcactata agcaccgttt tgtggaaagg ttttttttct 7740 gtttcgctcc agaactaaat agttgttgcg actattgtcc cgaacatggt tattaaattc 7746 ccgctcttct ctgtctttta attcttgtat ttgttttata tcgcgctcca caaagtgtat 7752 ctccggaaca tcgcctattt ttactaaata aacggctagt acagctcccg ttatatacag 7758 1308 SEQ.LISTING.txt ctgggcttgc atctgtctat agtggtcatt ttttttctcc accctcacat caatcggtcc 7764 gtttttgttt atcgaaaagg cggtgtgtgg aatgcggtaa cgggagcgat tgttgaaacc 7770 tcgtctaatg gtttccatac tgtcactctt gtacgtgtaa ggacatttaa tctctaacac 7776 aactaattcc tcgttctcta aaacaaagta cgcgtcagga ctggcgctat aaattcctaa 7782 tgggcttaaa aataaaccgc agtttaacac tctttctttt acttttttct tcaacttccc 7788 ctctattcct tcacagaccg cgtccataat gtgtttttgt tgtttgatcc attcttcctg 7794 ttctattcca tatttcatag cgacactctc cccataaaaa ctcgaacctg tacttttagt 7800 tgcggtcgtt ctgtttacgc gcaataattt ccagagatta tttttacact gtccacgagt 7806 ggcgcgttcc aactcaaaga tttcttcctt ggtgttttta tgacccggtt ttaattttgt 7812 tacataattt tccatgcaat atttttgagc catttttaac tgctcatcag tgaagccaca 7818 atttgataaa tccatgataa gaaatatatt aaaatgttaa ttattattcc gtcaattact 7824 tgcgatgtgc ctgttgtggc gaaaaagttc gaggacgagg tttatatagc ctgtgaggag 7830 atatgcaatt gtttgggtat taagaataat ttatccaata tgttacaatt gcgtagcgct 7836 aaagatctaa cgggcgttcg cctgttcgga acagataaaa aatttgtcgg cgaatccaaa 7842 cttaataatt atgtaaaaag ttattatctt taaaacaacc attattgcag agctttttat 7848 taaacgttca caacaattgt cgtacacttt tgggcgaaaa tcgaaatacg tcattacaaa 7854 cactggtctc tttaactaaa caaatccacg acgatgtgac tgttctgaaa aaatatataa 7860 cagtcgaccc gaattcatta taagtatata atggcgtctt ctgaaaacat atttttagtg 7866 atacgcaatg acattaagca ggtgactggc gaaacagatt tgattccgaa aatacagtca 7872 gatgttgcta acgtattatc gtctcttgct acggtcacga gttccgttaa cacgaacacg 7878 acgtcagtaa acaatgtttt aagtaaaata aataatttag ctacacttga cagtgtgaat 7884 agtttaagta ccaaagtgac tgacaccaca accgatgttt caaaagcaaa tactgctatt 7890 gacgatttaa ctaaacaagt tttagatgta aaaactagcc tagctggtgt tgttacaaat 7896 ctaaatacaa tccttaaaat tttacaacct ctaaaaccgt aaacgtcaag ttttgcaagt 7902 1308 SEQ.LISTING.txt aaaaatttat aaagcacacg ttttttaaat taacaaaaac aatacaacaa tgttcgtgca 7908 aacgctaatt ctcgggtcac tcttgcttag ttcagcgagt tgctcgagtg agagaaaagt 7914 cgatcctcat tacggagaca caactcctat gggttttctt aaaagatcca caaaatctac 7920 gggtgcgggc tatatattaa acgtgggcgg atcttacaac atttacaccg acccttttac 7926 taaaattcgc tcgactacct caaacaatta tttttatttt tacagagacg atggaaaata 7932 ttatatacga gacgagaagt gtaactttgt ttgcgctaat ccatgcggag aggtgtttgt 7938 gagcgcttac cgccttcagc actattgtaa attcaaagtg attcaagacc cggcgacgag 7944 cgcctttaaa atttacattc ccagcagcgg ctcagtgcct acgtatcgcg ctctcgaatt 7950 tttagtaaaa gataatctcc ttcgagcgaa agtcggtata aagaacgaag ctgaagttcc 7956 tgcgttattt ttcttcaaag accccgttaa gattcaaaac aagtgtccgt caatttcaaa 7962 agtgcaacag tataatctag acgcccatcc cgataatagt gttcccgata atagatgtgc 7968 tcatctcaac actcgagttt tagcggagaa cagaataaca ggttctctac cattaaaatc 7974 tgagagtgtt cgctattttc acttaatgat ggacgcgaag tacataaacg gagcgggagg 7980 ttttagcgaa acgtcaggat ccgacacaat ttttcaacaa cactatctta aacctaatgt 7986 gtttgctttt agaagtgtgc agtcttgtag ttttctgtgt cagaataaat gcggtttcgt 7992 ttatgtaaca aagaaataca acgacgactg tatgattaga gttgagcaga gctcggtgtc 7998 aaatagtttc tttttgcgtt ttacagaaaa caactttttt ttggcctaca acaccacaac 8004 agacacgctc ggtcatacgg atcgcgctag atcacgcctc tcctttgtgg acgcgaccgt 8010 ctcactacca gacgaatgtc ctcgcttaga tctagacaag cgcgaagaac gtgataataa 8016 atgtgcttta agtttagcga acaatattgt tatcaacatt ccacatatgc ttttccttat 8022 tttactaaat tataatgcta ccagagtgta ataaaaaaaa agatattgta acaaacattc 8028 gttttatttc ttaaacgcag tcattatgga gtctttatta ataacacata aagcggtgaa 8034 agcgccgaga agacccaaaa acaataataa caacaaacat ttacaacatt tgcagcaaca 8040 acagcatccg cacttttttt cgtcttcgtc caacaatccc tcttcttcgc ggatctcaga 8046 1308 SEQ.LISTING.txt attttgtcaa aacagctgtc acagcagaat cccattttct ctgtatacaa tatggtgtgt 8052 gatcgatgag gctatttatg gtttatgaat aatcaaaatg cacatcacca agactttgtt 8058 tgatgacgcc ttttccaaac ggcaccgttt tccgtttctt ccgtccaatt tactgaagga 8064 ggtctgtaga cctgattgac aattttttca attattgaag aaacgtttgt cttgatcgtt 8070 ttcacgctct gaggagcatc gctaccgttt ttcttatcca ttgttaagat gagtatgtcg 8076 acctatttcg caactcttcc tttttatact cctctttaaa gttataaata ttcatgcaaa 8082 acaactataa tttattcttc aaattgatgc caacatgcac catttgttta gatttataaa 8088 aatattttgg caccgtcggc atcatttaaa atttatggta tatgttaacg aggagaatgt 8094 cctgtgtgac attaaagatg ttgttttccg agtttgcaga cgtgtatgac gcgctaataa 8100 atttaagctc gttgcacgaa atagcagcgt gtattaacga tgcgcaaaaa aaaatagagg 8106 tgggcgcgga cgaattgcaa gtttggctat atttattgct gacgtttgag caaaaaagca 8112 aaattaacga caaacatttg ctgacggtgt tttgtaaatt acaagagcca aatatagaca 8118 gacgcaattt gcaagaagct tttaaagtgt acggtgtggc gcaaacatgc agcagcataa 8124 taaagcaaga acaaaaatgc actttgacta tgttggaagc gtacaatttt ttgctggagc 8130 tccaaaatat gcctacaaag tcgtcagcgc tgctcaagca ctttaaaagt atcagcgaaa 8136 agtgtaatgt tgcggcaatg aagtgtattg tgaacctaat cagaaatagc ggacgaaata 8142 aaaagctaat tttaaagcgc aagaatttgt atttgtttaa gcaaatgttt ggaaagaaaa 8148 acatggaaga aatggacgca atgatggaga agatttatca ttgtaagagc tttgaatgtt 8154 tgaggaaatg tgtgccgggt cagccggtgg aaccgatgtt ggcacagccg tgcaagagct 8160 ttaacaatat cgactttaaa aaaatgtgca ttgaaataaa atacgacggt gagagaatac 8166 aactgcacaa attcgatcga accatcacat gttacaagcg aaatttgaac attagcagca 8172 agtgcgatag actagtgcca attattgaga gggttctaag aaacgtggaa aacataatat 8178 tagactgtga actggtgggt gaaagtgaag aaaactatta tttggtcgtt tttgatataa 8184 tatatctaaa cggaaaatgt ttaattggaa aacggttgga ggaaagaaaa agaatattaa 8190 1308 SEQ.LISTING.txt atcaagtttt agagtatgga gaggagagaa tgtttttaat tcaaagtata atatctgaag 8196 ataaagaaga tgttgtctcc tacgtaaaga cttttttgaa agaaaatcaa gtcgaaggtg 8202 tagtggtgaa agactgtaat ggattgtatg aaccaaagag gaaaaagtgg ttgaaaatta 8208 aaaaaaatta ctttagaaat gtttgtagcg ccgaccttgt ggtagttggt gggtggaaaa 8214 aagaggagca taagcgtatt atcatttatc tagtcgctac tcctttttat gattgtaaaa 8220 atcaaaagtg gatgtttctg ccggtttcca aagttaaaat tgccaaacac aatctagagc 8226 attacatgac cgattacagt gagacggggt gcgattggct tgtgaataac gaatatttaa 8232 agaggttaaa caaaattccc aatatgatag caaaagatcc cttttccatg cctgtgtggg 8238 agatggaagg agatttcata cgaaatgcgc aaaatttgtg gtgttgtggt gacatagtga 8244 gtgattacgt ttccattcgt ttaccgcgct tattaaagtg cgagacgata agtcttttaa 8250 agaagcgtcg cgattgctag atttaaagct tctatgttgt atcagtaata aaaattcaaa 8256 ttataccgag ttgaacaact tttatctgca ggataacgtg aagattgata ttctgtagaa 8262 tataagccgg tgggcactgt gccttttatc atcttcacca tgccaatctt taacaagtac 8268 atatatggtc atcgattcct ttgggtgaac gatcacgagg agaattatta ttcgagcgag 8274 gacattgcca aatatttaag atggacaccc gaaaagcttg cagaacgatt gcgatttgtg 8280 gacgattcta attggatcga ttgggacgag ttgaatatac tcatcagtag tttgactctc 8286 aatcaaaacg catctcacct gtttcaatac gatgactacg cgtcggatct gtctttttta 8292 actacaggtg gtgttaaaga gatggtggaa aaggaatttt atgatgatat tttaaaactg 8298 atggtcagcg aactgttttg cttggacgat attaattttg aaccaaacgg gaaagttttt 8304 aacctttcgc ttgcaaactt tgaaaaacct gtcactgtag cttctttaaa agtggccgta 8310 aacaagcatg gatgtatata cacgagcgcc ggtaacatgg tttcgaaggt gccttcatat 8316 gtacgcttaa agagtacaaa ttgtgtgccc gttgactgga gaagaattta tggatttagc 8322 aaagaagtta ctctatacga ttactccaaa actcgttgga ttggcttaaa aaagtctaat 8328 actttattga cacataaatc agaaccgtta ttaaaccatt tcacttcagt gttggagtat 8334 1308 SEQ.LISTING.txt gctacagcat tagcaacagt caacatgaac accataaacg agttggtaga tctgtgcaag 8340 tattgtgaaa aacgtcaagt ggtggattgt gtgcgtaaaa tacaaactgc gagttgcgga 8346 atgaaagaat ttttaaaagt taatgtaaac atcaataaac ctctttaaca ttcaaaaggt 8352 cgttttcatt tttgataagg tgtatctgag aacgggattc gtgacgcgcc ataacccccc 8358 tttttcctat ccatatatac ttaaaatttg gcaacatttt acgcaccgag tgcagcaata 8364 gtttaaactt tgtgggcgct gctgcgaaaa tcttcacttt gacatcagaa tcctcctgta 8370 aacccgtcaa ttcgattaat cgtaaacgct tctctcttga ttttctctcc cactcattaa 8376 ccgctctatt gtctattaat tttaccagca acccgtttcc tttctttgaa caaaacaaaa 8382 catctttaat gtcaagatcc agcgctttag taatcaattg aagagttttg ttataatcgt 8388 cccactcgcc caatccataa atttccacac agtcgtcgat gtcgtgttgc gattgcatgt 8394 ttttcaaaac tccttatctc taataaacat atctaataag tgtgttggaa aaaggaaatc 8400 ggacggaata tgactcacgt caccaataca caaaccgtct tgcttgtaac atatcttatt 8406 gtttttcaaa tatagattca gaaacacaac tgtgttgtga tatatatctc ccccgctaaa 8412 ctttactcgt ccgtgactag taatatgtga attgagcccg tttatggctc tttccgccac 8418 ttgtttaata tcttctttct gtgtattttt gtactgttta gtgcttgata ttaaattata 8424 actaccctta gctccgctgt tgacaatatc atcaaaacac ccgtctagat tttctaaatc 8430 tttactttca caaatcattt cttcttgttc aattatgcta cataatcgtt tgaaaagtaa 8436 ggtagaaaaa ttggagctca acaagagagt gacatcggta aaaaaagaat cgaacctctt 8442 ggaaaatttt aaagttttgt gatgattcca aatgtgccaa gccaaaggaa atttggctat 8448 tttttctcta caacattaat gtttttgtat aaatagtata tctgttgtga gacaaacgat 8454 aatttgtttt tgtcaaagca taagaaactg tatttaggat cgcaatacaa caacgattcc 8460 agttcaatta aagagtttgg ataaggtaaa tacgtgataa cttctttatc tccgtcgcaa 8466 tctctattgg ctcctacaaa cgttccgaga ccaactttaa tgttccaatt cactccgttt 8472 ttctcttcaa ttactctcga aaattgtgtg gagagttgcg agatgttagg atggcgagtg 8478 1308 SEQ.LISTING.txt ttccacactt tcacagatgg cactcgtcga ccataatagc gtagtatact cggtaagggt 8484 ggtataacct cattgatccc gttaaaacac tgaacattag cataaaagct ggaagtgttt 8490 aaaaacgtcg agtacaaata ttggccagcg tacccgtttt tgttttgtat aagatctttt 8496 ataacaccct gtgtaagggg aattttctgc atacaacccc aaatgtttac caagcctcca 8502 gactttttgc tattaaattt tttattcata aacactaaaa agttatggtc ccacagtgtg 8508 aagtttggta agatgagata atcaatatca tctgtgtatt tattaatata gagcttccga 8514 agaaatacgc tctcttcaat gtctgtaatt atgacattat tagctaaaag cacttttgct 8520 aaaacgtttg tatatgaaga tgtttcatta caatcttgat gtgaagtgat cagctgtccg 8526 acaacagaat tataataggc acacttgttg tgttttagat cgctcaaaag atctcttaca 8532 aattttccga atttctcact tgtcatcatt atacaatttt ggagagcatt tatatcgcgc 8538 aaaatagtta ttgaggttct gtctcgtttt gcaaacttaa ctctttcctc cattgctaac 8544 acaaacggaa tcgagttggg gttttggtat tttaactaaa aaaaaaccag tacacgtcac 8550 gtgacacgca ggacattcaa gacacgtcgg tgagcattcg ctgcaagcgc aaaaatggta 8556 gcatggtaat aatacgcaat cgatttcgtt acatttacac agtaaacaaa atggaatctt 8562 gtaatggttt ggtgtataat gcaaatcctc caaagcggga gcgctagctt tgaaattact 8568 ttgttgattc tcttcaacgt tcttctcttg ggtactgtta acacacaatg tatcagcaca 8574 tctattaata ctacatagag agtttgaggc ttggtgtctt ttcgaggggt cgtcatctgg 8580 tgcccaatct tttattataa ctccgcacge gtaacaggaa acgcagtcgc ccacgtttgt 8586 gtaataaaga cccgctaaac acatacgata gaccaagtgc ttaagacatt tagggtaatt 8592 tttaaagcta agcgaccgat gctccaacaa attatatgag tggtgtgccg tgtcaatagc 8598 taagttagga tagttagatg aaacgacacg tggtgatata aacgaggtat tgaaataatt 8604 acccgggttg cattggccaa aaatgaaggg acagtgaggt gaatatcttt tatgatcgta 8610 gagggcgttg gtgtttttac taaagttgta caggtcgagt ttacaaaaag cacaaattac 8616 cctatcgctc tgacccgtgt aataaaatcc caagctcgct aaacgggcct tatcctctct 8622 1308 SEQ.LISTING.txt tccctgccat tgatcaaaag ttttaagacg tgtttcgtaa gagttcattg ttcaaaatta 8628 aaacaactaa tacggtaatt tagagtataa tttattttta aaacaataat cacagatgta 8634 ggtacaagaa aaccaatacg aatgttgagg ttcaacgtta cattccgaca ttatcaggtc 8640 gtgttgctcg ctgccgctac tcgtgtattg ttcaaaacat tcttcacaaa tttgactttc 8646 gtcgatcgag taaaatttga gtctcactct ttcgtttgtt cacacacatt aatcttttcc 8652 agaaaagctc tgatgccata gttacacgtg tagttgttgt cataaaagct agtttttaac 8658 acactcaaac actcatagta attttttaac aaattataag tatttattat acagtccaga 8664 gtgtgtccct tagtttttcc attacaatta taatattcca tttgcactct ttgaagcaaa 8670 atttttggat cgactctttt cacccgctcg gcccgcatca tttcttgtac cacatttatt 8676 atctcttcgt gatgtttctt tctctgtctt agcttctcaa aagtaatgca gccgttcatc 8682 ttgaggtctc ttgttgttac atgtatgaat aagagtatga gattgaaaaa tttataaact 8688 cgtcatcata taaattcctc agacctcacc cccttccatg tgatgtacga taacacagct 8694 aatataaata cggttacgac attaacgggc ttaaccaatc cggtatcggc tgctgtatgt 8700 tgaggaggtg ttagtgcttt gataatacta tcattagtca agtttaattg ccgcttcttg 8706 agatcataat atatcggttg tttgtaatca aagtgttcga gcattccttt ccgaatatta 8712 ctgcgatagt ttttcggtgt agttttcaaa gatagaataa taatatcttt ccaagcatct 8718 tctcgatcgt tactgataac ctcaataaag ttgttattga caatttgcca attgtacttt 8724 tgaagaatgt cgaagagacc ctcggaaact gccattgatg ccggcgaatc taaattgaag 8730 tgtcttcaaa tcagcgatac ggtaaccgag aaatatattg tacgaattaa caacaatgaa 8736 gtgcacagaa ttcgtgctgg atggaatagt gtgattgtaa caccagaaga ttttgctaat 8742 atacacgtta acacgcctta taattttgtg gctcagaaac ggtcggaccg taagtggtat 8748 ttattggaat acacagaaat cgaaagacca atatacacaa aagtaaatgt gttggatttt 8754 aacaatttca atggatcgga gactattatg tgtaacttca aagtgattgc tggttatgag 8760 gttaaaaaag aaccatattc gttaatcaag ataattggac tgatcagatt tcaaggtggt 8766 1308 SEQ.LISTING.txt gtgtctcaat gcgatgcatt aatggatatg tccggtcgct attcgttgat ttacaaggat 8772 agcgatgata attccgatcg tgtctctaaa acgctcaagt ttgtattttc gttgatcgat 8778 aaatggtgca agttggacgt taaatgttta aagcatattg tgaggaatga ggaatatttt 8784 aaattgagta ttatagaaaa ctctgctttg caaattgaga ccgatcccga aattttggaa 8790 caactcaatg aatacaaaca aagtactgtt gagagcatct cgtacctgca caaatctttt 8796 agaatggttg agataaagga gctggaatgt aaagttatta attattcagc aaaaggaaag 8802 gataaaaagc tatacaattt tgtgcttaat gtaatagatg atggagtcgg aaccatgccc 8808 gcgatatctt atcctcacga cttatggtcc ggcgagatgg tgaatgagaa gcttcacgat 8814 attctagcgg ccaatgcaga agtaaaatcc ggcaatagag tgtattgtat tctgaacgaa 8820 caaacaaacg gtgtacgggt ctgcgtaact tccattttat gcgctacgcc ggacgaaaca 8826 tacactttat tttaagatga aaataatgat tgttcttctt ttgtaataaa actatttgat 8832 tctatttgat gttttttttc taacaactct ttaaagtcgt catctagtaa attataatca 8838 ggacgttttt ttaaatcaga aagagtgtcg ttactcaaaa attgtgcata tgtatcccaa 8844 cgcttgtggt taacgttctt ttgttttatt tcccttatta atttttgaag ctcctcttcg 8850 gtgctacgtt atatagtttg tttacattcc aagatagatt agatttgggt atttttcgtt 8856 ttggttcttc gttgttttca atttttctgt aacgagccaa gttttttttc acctgcttta 8862 atatattact attagttgca ttttcaacac tctttttgtc tcgatgatac agctcttcaa 8868 tctctctcga taaatgtgcc acttcggttg tgcgctcttt taagtttgct cgcgtttctt 8874 ttaattgtgc ttgtagcaaa tcgatttctt tgacaagttt atcgttttga agcttctccg 8880 cgttaagttc cccctctttt agggttaaat gtttactcaa ctgatccacc tcgttttggt 8886 cgtctgcttt aaaaatgcgc aattttgaat tttcaatctc caacatattt aacttctctt 8892 cccatttagc tttgtcctct tgcaccaaac tttgtagttt tacaacatta tttaatatat 8898 ttttttgttc ttcgttctta tactccaact cctcttcatg atctttcgta atctttttga 8904 tgtgctcttt taatttatcc aattttttac tcatctcttc caaatctttt ttcatttcgt 8910 1308 SEQ.LISTING.txt tttctctttt gtactgccac tcgatagcgg catgtccttc ttcataaatt tttttaacat 8916 cttcgtcttt actagaaatc tgttctttta actcattgtt ttgtattgtc aaatttttaa 8922 cttgcatcat gtattcggtc acactttgct cgtttctatt caattcttgt tctttatcta 8928 tcagtctcat tttacacgct tgcaattcct ctctgttttg atcgtacatg tttgaatagt 8934 atcgctcacg ttcttcgaat tgtaacagtt tagtgtttaa cgttttcttt tcttcctcta 8940 attcactatt tttttcgaga gtatttttaa gtttttgaat cgtctctttg tgtattatct 8946 gtaaattttc atttactgaa cgcgcttctt gtaattttgt caaagtgctg agatatattt 8952 gactttgctc gtcgttattt tgtgcgcaac gttcttgaag agctaaacat ttcgattcaa 8958 atgagtctct ttcgtgtttt aacacaatta aatcttcgga ttgaattttc aagttggcct 8964 cgtaagacgc aattttttga ataagattaa aattctcatt ttcaagctct tcacatctcc 8970 tcaccaaaac ttcaattctc tcctcttttt cacccacctc gttagccatc tttaacaatt 8976 gaccggtatt tacagaaatg gtcatttttt gactgttaat aacattgtta agctcgtcta 8982 tatttttttt taaaatttct tggttggcat cgtggttatt tagctcgatt tgaagttgag 8988 tcttacaatc atttaattct ctctcataca cattggtttt tttaaactct tcctctaaca 8994 ttttggtttt tttttcgaaa tcattctttc tctcctctaa ggattgtaaa gcgtgatcaa 9000 tattagaaaa acactttaaa atactttcag ggtcgtcgtt atcatcacgc ttccaccgat 9006 ctacaaattt ttttatatta cccaccaagc gtatgcattc gtctcgatct agttttttca 9012 cacccaaaac gctttttaat acaaataaaa gattatcgga cacaacttct ttgtctacat 9018 taattatacc gttttcctcc tcactcccac catgttcggt ttttgtaatg taattataat 9024 tataagtggt ctctttgttc tttgtattgc ttaaggctcg aatcaacaac tgatctgttg 9030 ataacccgtg taattgtgga tgataagcca ataaaatgtc gcgcaccttc ctttcgaaat 9036 cattgttgtt ggcgcaacca tatctgatag ttgttccttg acgcgctatt gtcttgatca 9042 aattgtgcac ttgtgttggt gttatatcga caccgcgata acgagtcaac ggttccataa 9048 tggacgacga ttatctctat tgcgactacg atgaaatgat attccaccaa taatacgctc 9054 1308 SEQ.LISTING.txt ctcgccaaaa aggaaactct acgatgaaca cgaaacgacg cctgtcttaa agaaagagcg 9060 ggacaatagt agtgttgaaa aggacggcga gtgttcttcc aagtataaaa aggaacccgt 9066 ttgtgagacg tctgaagatt ttgaagtttg ctcgaactta ctagaaaaag tggtcaagtc 9072 tgatagagag accgctcact attctgcaaa ttgtgtcttt aaaattacaa aattgcacta 9078 tagttcttca tttttataca tttttttaac gggaaatgac aacgttcaat attattttaa 9084 aacttactgt ccgatttatt cgtacaaact ttgcacgcac cgttttcagt cgtgtcgctt 9090 caattgtcaa tcgtacaaga gtctggtggt gacgggatta aaatcaagag aatgtcatcg 9096 cgtcaatgtc ataaaaatgg aaaggagtaa atgttcggga gaaaagtatt tgctcgacga 9102 aatgtgtaac gatgtcaata gagtccaaat gcagacgggc atttacgagg gagattatgt 9108 gagattcaaa gatggtatta ctgtagacga gaatggatgt gctaccggtg ctgtgtcgga 9114 actagttaaa gtgactatgg aagagttgac tcaaccgatt gatccgattg tcggatctta 9120 cgatttggaa acttttaccg acggtatgcg tttctctaac tcggaagtgg atcctataat 9126 taccatttct tatgtcttac gaaaacaaaa caacaacatg tcgcgctatt gttttatcaa 9132 cactaatgga aaacgattta gactgaacga tgtttactta gcaaacgccg aatactgtga 9138 cggaaaggtt attgttgcgc catttaataa cgaacgagat atgctcgtta cctttctcga 9144 agtgttatgg cgcactaacc cagatgaaat tttggattac aacggagata aatttgatat 9150 tccctacatt attggaagaa tgaagaaatt aaatattgac gagcaattca tacaacgtta 9156 tgatcttcca aaggtttctt ttaaagtgac caacattcgc accaagtttg gatacggttt 9162 taattcccac tcaatggtat attacaatca tcttgacata tatcagttta taaagagttc 9168 atatgatgcc agtaaaatgg agaacatgaa gttggatacg gcagctactt tttatttaaa 9174 tgtcggtaaa gtggagctaa gcgttaaaga aatgatgacg ctatatcatg agggtagttt 9180 tgggaaagtt gttaaataca acgtaagaga ttcaattctg cctttggaaa tattttttaa 9186 atgtcaagta gccaacaagc tatatgccga cgcgggcatc atgtacttgt gccgagatga 9192 ttatttgaga acaatttctc acaagatcaa cttggcccta ttcagtagat ctatttacaa 9198 1308 SEQ.LISTING.txt cagaaacgaa aatggtgacg ctgatccata tttttataat aaatttgatt taaataaaat 9204 tatgggaaga aaaaagtcga tggcgagagt gaacgatgat gatgacgacg acggccaaga 9210 agcggcagca gcagaagaag agggggaaga aattgatttt accaacttgt ctcgttcaca 9216 cgtgcctcta catcttattc cgccagacgc gaggaaatta tgtcctttga agacacgaat 9222 gaagtatacg ggaggaaagg tgttgtcacc gaatcccggc tattacgaga ccacttttac 9228 ccttgatttt tcacaattgt acacaagcat tatgatttac ataacggcgt gtttgtctaa 9234 tctatttttt ggttccgacg gttacttata tttacagcac aacgagaatg ctgttacaac 9240 taaattctta aaagaaatgg ccagcaaacg agctatatgg aaacaagaaa tgaagaagca 9246 cgcgcccggc tcgtttacgt ataatctata cgactcttgg caaaacgctg caaaattagt 9252 ttgcaacttc aatatgggtg gtttggtatg ttttgcaaac cgctagcaaa tttgattacg 9258 caaatcggta gagaaaagtt aggcgaggcg aaggagaaaa ttgaatgtct gagtggaaat 9264 gaggagatta tgaagaaatg gaatttaaca aagatgaagc tgtcagtagt ttacggagac 9270 acagattcta actttgttgc aatcgatcta gagcccgagg aatttaaacg tttgggtgtg 9276 gatggtttga aaaagatgat attacaagac attctggcgc ccgttaacgc cgtctggggc 9282 ggttcgttta aaatggaatt agaaaatata atgaagtgta tgttgattaa aggaaagaaa 9288 atgtacatgt gtttaaaaga aaacggaagt ttgtacaaga ggggttttaa tgtgaaaaaa 9294 gattcacccc catttctacg cattatattt gacaatgtca taaagcgaat actgacaaat 9300 catagtttag attgtgtttt gaaaaatatg ttaagtgagt tgaaaacgaa aagggacgag 9306 ttttgtgcta aaaaatgtga tcagtactca ttttctcaaa ctcttaacga agacaagaaa 9312 actacgattg catataaatt atatatggaa ctgaaagagt cttctaatac caagtatata 9318 ccggcatcgg gtgatcgtat tccttatata ttagaagata aacgtagtaa taatgtaaaa 9324 gataaagctt ggcctactca gatttttgaa gaccaaaatc ccagttggaa caagcatttg 9330 ggtatagtgt gtacattttt gaacgacatc atgtcaatgt taagaaacga taccttgttt 9336 gtgtatactt tccaaatcat ttgtgattac tatcaaaagg atcaagttta tgatattgtg 9342 1308 SEQ.LISTING.txt tatccggttc taaaagtcat gactcagtct aaaataaaag atatcatgtg taaagagtta 9348 aatgttaaag acaagaagaa actggacgaa aaacaaatgg aggattgttt cgaaagaggt 9354 gtgcacaagt acattcatac gcacgagttt acaatgagta aaacgcctcc caaatatcgc 9360 atcaacgttg agggttttaa cgacgattgt ccagcctgta acggcagagg tatatctgct 9366 gttaaaaaaa atatgtcact tgaattaatt gaaaatgagg tttcaaagaa aggaaagaaa 9372 aagattgtaa acaaagtaga ggagaaacag gctgtagttg ttgataaaaa aaaattagtt 9378 aaagaagagg ttgtcatact taaaaaacgc aaagaaaaaa agtcggtagt aggcggtaag 9384 accaagttga tagataagta cgatttgaaa gaggaagatg aatggtggct gaagcccaaa 9390 aataaaggca actgatttta ttaaatatat tttattgcat tgttacattc tctaattaaa 9396 aaactagcaa tatacgaata acagtcgtcc tcttctaacg caatttgtaa tctatttttt 9402 atttcttcat gatccgaggt gtttagcaca tttgtaatta tgtttattat atttcttaaa 9408 ccaatatctt cttttatttt gtcgtacaaa tacctaaact gatctcgttg taagtctaat 9414 ttgtatccaa acaattgaaa caaggtgtct tcgtcgagtt tatcttgtaa aaacaacaag 9420 agtatcctgt gtagcttgtt caacagtgtt tgttcgtctg gatcgaacct cttctctttt 9426 tcatgatcct ctaaaataaa ttgaagattg ctgcggaggt ttttggacac aaaagtaatt 9432 ttaataggat ttaaactaac caagtctttt aaataatcaa agttcatggc tgctaccgtt 9438 gatgtactga ttgtgaatta ttttgtatta ttctaatgaa gaattgtttt tgtttaatat 9444 agcgtcaaaa gcgtcattta tctgctgctt tttctttaac tttttcgttt gctcattaaa 9450 taaagtgtct ggacccgact cattatttac ataatgaatt gtagcacgca aaagaacaat 9456 accaaaagga ctaaaatcgt tataattaat tcactgcctc taaaggctgt atttaatagg 9462 aaggccaaaa ccacgagcgc tattacggga gttataatcg acattttctc tataaaaatt 9468 ttgtaatcct tcaacgggag cttataacaa caagatgtct ctttcagaac gttacaaaag 9474 gcttattaat gactgttttg attacacttt cttagaaaaa tacaagttta attatggaga 9480 tggtaatttt aaaaaacaca aaattttcaa taccaagcta cctctttata tacaaagacg 9486 1308 SEQ.LISTING.txt ttacaattta cacgaaaacg attggtttga atacgttaaa atactcatag attcgctcgc 9492 cgacaaatcc tggttctcgg tttcgttaga agcttatggt actatcagtg aaacattttg 9498 tgttactcgc tattcgtcct ggattgacgt tgtaatgaaa aaaggagaga aagcttgcgt 9504 tcgaataaaa aacagcggac caagcgacac ttccatagat ctattttatt acaccctcat 9510 taattttgtc tactcttttt ccacaattga aaaacatgac gataatatta aagatcttaa 9516 agaattgttt aaagccgcat tatggcatta tttaaacgaa acctccgacg gttattactt 9522 ttttgaccac actaaaaaca actttttaat taaaatcaat tagacccctt tcatcatttc 9528 cttcagcacc atcgttgcta gactcgtcat ttacaagcgt cggaccgggg tgaaacttgt 9534 taatgtaatg ctttgttgca gtcacggacc tgtgattcat aagctttgaa gttttattta 9540 aagaaagacc gctgttcagt atagtgtctg caacatagtt tcgaatcatg ttagatttaa 9546 aatttgtgtc ccgatccaca aaaacggtgt cgactaacat acgaaagtct ttgaagcgag 9552 ttgggctttt agatgatatt ttgtttagga gatcctctgg gacttttttg tatagctcta 9558 tggcggtgca aagagctttt ttatttttac aagtgacata acaaaaattc accttaccat 9564 gtttagtaat aagattcatt actttatgtt cacccttttg caaaattttt tctaaatcta 9570 ccaattttat ttgataagca tttgttattc ttaaacccgt acctttaata atgttaaaag 9576 ctattgctgc acgaagcaaa ctttgattgt tgtaataatt tttatattgt atttctttgt 9582 caataaaatc acttatcgga tcaataaaat cgtcttttaa aacaattgtt ttatttattg 9588 ctaagcgatc tttcttctcc ctatcttttg gcaattcaac attactcggt atatagtagt 9594 cgggaatctt cattgatctt gtataaaaat ttattgtggc ctgtaatctt ttcttcgaca 9600 cattacccat aataagcaac ctttcaataa aatcctctac atccattagc ggttccgctt 9606 taagcaaact ccctaactct ctttcaacgg tgtaccaacc ataattttcc agatcttcct 9612 cttcgatcaa acaatatata atttttaata acagcgattg gaactcatct ttggttgttt 9618 gtttatactc ttgcgatttt ttatgaggct gccataaatt tttatgcttt ccttcacccc 9624 taggcactac atcgtcaccg cgcttttgtc tttctattgt ttcttctaaa actcgcggaa 9630 1308 SEQ.LISTING.txt aaattggatc ttgcttaatc actatacgcc aaatgttata attattaata tttctaatac 9636 tattagtact cgactcttcc gtagatgtat tcatcctcct ctggtatata ttcctcgttt 9642 aagtgttttg atttgtttaa gcgtgacaca acaatataaa ctatcacaaa cactattaca 9648 ataacaacta tgaaacctat cgcataaaac catatgttta agggttcgtt tttagcattt 9654 gatacgttat ttcgccatca cttttgctgt acaacgactg tggtgattcg ttgttattag 9660 cgtgtgccaa ctttaaaggt ataccttcta aattttctac tttttttagt ttctcaaaag 9666 gaatgtgtag cccgttcatg atcacgtatt aattaacaaa caaacgtctc acacactgtt 9672 ttatttaatc ttattttcct ttacgtacta tgacaaattt ttatatttaa tgttgaggtc 9678 ttgtatcaaa ccgcgccgga gcgcttcgtt ttcaaacgcc agttcggtca aactctcttg 9684 tataggggtt gttcgatgag cagtattaga gacgatctcc tcgtacattt tttcgtcggc 9690 cgcatgatga ccagcgttga ttgcagcttt ttctattaac atgtatacat ttgtcgatag 9696 cgtgagaggt gcgttaacca agtaagcgat attgtctcga aatttgtaca cctttccctt 9702 taagtcattt tttagtatag agttaataaa atatccgtta tgacttccga atagcacatc 9708 ttctactaaa ttattaaaca cgtcgttgca cacgttaagc cgttgattag atctatcagc 9714 aacgagcttt tccacgtttg gcgcaatagg acttctgtgt ttgagcgtat ttaaatattc 9720 atcagccaca tcgttgtgta caataggaag aggtttactg tgggtaacgg cgtttgccat 9726 ttgatacttt acaacatcgc ttaaatgtga tgcagccaca ttgaggcgtc ttttataaaa 9732 cttatccgca tacgctttca ttataggtga gatgacaaag cttttatcaa aaattccatg 9738 agtaccgccg cttaactgcg ttgcacctcc atattttttt tccaaatttt tatagtaatt 9744 aattagctcc tcatctgttt caaacctttt agtgacgctc accggtaggg gttcggcttg 9750 aagaaacaaa tctctaacca aatttaaaca tgcaatttgt tcgggtgtta atttagctgt 9756 gttattggag cggtacatat tgatcatagc ggcagtggtg ttccagttaa taaaattatt 9762 accggcttgt gaaacatcac taccccctgt tgtatccata cctcgtcttg tatccatact 9768 atttttgtct taatttaaat atactttgtt atttacagat tttctcaata aaattagcac 9774 1308 SEQ.LISTING.txt gtttatttaa tttgtaatgt ttgcatattg aaacttttgg ttttgataat aaataattat 9780 ttacaatgta taggaggatt aataaaaatg ctattactat aatatttaag gcgctaaagt 9786 tgaccaaatt tattaataat actacaatta aaattgttat tattacagtt tgtacgcttt 9792 tacgtttaca taaaatggat tcgcaattct taaacgcaat gttaaactga ttctctcctt 9798 caatataatc gcgcaattct tgctttgtac actcgtcgca cataaacttg acacaaacgg 9804 gaaggtgctc cttttccgtg tccacatttt gaaaagtttt cggttgactt ccaggatgaa 9810 attcaaatga aaatttgtta gaaacaaaca cttgggcgta gtagtgagcc aacacagctc 9816 ctccagtttt tctaactttt accctgcata ttttgattac attgggttcg ttggaagccg 9822 ttaaactata atcgtaaata taacgtaaca acacttcaga atcaaattta acgcggtcct 9828 tgctattgtt ttgactcgac attgaatcta tcaaacacgg acaacttact agtagacggt 9834 tttggttcgg gaattttaaa ttcgggcatt tcaatatcga tgtcggtgct cgaaacaatc 9840 tcctcttgat caatttctgt taccattctt gaattattta taccttctaa ttcctcttct 9846 tcttgttctt tttcaacact tataggcaca gaaaacttaa atggtctagg aaaagtaacc 9852 ataaatatgt tttgatcttt tttcaaaaca acgctatcta aagtattagg actgcactca 9858 tggcatcacc ctcgacggca ttgtgaacaa ctaagtaatt tttattacat actacaatat 9864 gatgatgaat gtcttttaaa tgatcaagct tttcgctttc gagtatttgc aatttgtagg 9870 cgcctatgct tagtttttgt aagttgtaat cctctttcac tttaaacatt atttgttctt 9876 cctctaatac aggatatatt ataatgctat ctctatccac gcttgttgtt gccatttttc 9882 ttgtaataat agtaattttg ttttacaacg tatttataga aaaagatttt aatcagagcg 9888 cgtttaatgc aaaagtcaac gctcttacag agtttctcaa aaataaccac gaacccctgc 9894 cgcgaaaatt aatgtttatt agtcacgtgt tctctccgta ttattacatt actgagtttg 9900 atgtagaatc ttttaaaact ttatccgtca aagcacacga tgaacgagtc gaacatttta 9906 gctttttgga ccaaatcttt agagaaccga ataacgacga cagcgacagt ctgagcgaga 9912 gaggaggcgc tccgatatat accaaatttc aaaacagaat aaaagaatca agtataagtt 9918 1308 SEQ.LISTING.txt ttcatccaga gagtgtaacc aagtttatag cgcacgctga tgatggagac tcgattgttg 9924 aatgtcacaa tggagaattt aacggcgccg aatgtattcc ctatcccatt tgtaaacagt 9930 caaatgtcga tattccccta actgaagaca ctttaaacag acttgttttc aacaaacttt 9936 tagccagaca acgcaacata actaatgtta tgaaaacaca tcccagtctt tacgtacgct 9942 gtgatgcaaa tttaacgccc cacatgcaag agtgtgatat tggagaaaca tttttagaca 9948 atcggtgtgt tacagaacct ttcttgttta cagacgaagg tgttgttctg aacgccaaat 9954 tgaacaaatt taaagttccc aacatcaaaa ttgtttcagc taagttgcac aaaagatatc 9960 acaatgatat acaagaagaa agaaaagaat ccgccgtacg catcgttgaa cttgatgctg 9966 atgacccgcc aaaaaacttt gttaaaactt cttttgagtc accagtcggc atcacgtcaa 9972 agaatactaa taactattcg ttgagagtaa atcttggatt tcaaaagaca gttgggttta 9978 acaaagattc tttagaccgt tctattatcg aaggtttgaa aaacaaaaat agtaatctag 9984 tgtttccgat caatgacaat tctttgcacg acaacacgcc gtgtacagag tacggaaccg 9990 ggcacacgta catagattta acaataggta cagatcagtt tatcgagtgt cttgataatc 9996 acaacatttt tatacattct tgtcttacaa gaggtttcat ggacggaaaa tacttttgtg 1000 acaaagaaga aatttgcaca gactttgagt ttggtgcagg tgaaattatt aacagcttaa 1000 gtaacgatca catttcgttt gatacgggta aaacagtttg ttcaaattac caaatcactc 1001 aaattgtaga atgtgacaca gaaaacgttg taccgtcaaa acaatttgac catcc,attca 1002 atgtctcgct cgaactgaac cttcctaaag aggtttacaa cggagagttg tgtgttcctt 1002 tcgacgttga tctagtacat ataaaaaacg ataattttaa agtaaatgtt gagaacaaat 1003 tgaacataaa cttttcaaaa tcaatgatag gaagagtgag taaaattacc actttggaga 1003 tgttatccgc tgccaagttg agcgctttgg tgacgtacag tcgtaatctg ggagaaatat 1004 gtctcgatcc ttacacttgt gccggtttgg agtgtgatgg agaaggtgct gtggtcgtag 1005 atatttttga caacacacaa tacaatgtgt gtgatgaaaa cggagaggct gtgcaacata 1005 aagtgcaaat gaagaaaacg agtatatgga ctttgtgaaa gggaaaattg tcgaaaacag 1006 1308 SEQ.LISTING.txt caattaccac ggagagtgtc gtctacaaga aggcgacgat tactttgaaa agatgtttag 1006 ggaggtgcaa gacgtgtctt gcttttacac aatgccaatg tttgaattga ataaagaaga 1007 tattatcaac taaaacggta ctattctatt gttacgatag ttgacgttcc ggttgtacct 1008 attgttgtta ttataataag cggcgctagg tcttgctgcg gctgtgggag aacaaagatt 1008 agctggctga tccgctctgt ttattgctaa ataattggga ttattataac taggatagtt 1009 attgttcagc gcagttcgag tgtgaacaac gtaaccgtta tcgtttgttg tgccgttccc 1009 cataaccgtg ttaccaatag atcgaagatt gtctcttagc agatttaatt gagattcaat 1010 acgcttgtgt tgttggagaa tttccttttg taccctctcc agttcataat gtctatgcgc 1011 tccatctggt gcgtaattat ccatttaaaa aatccttatc tatatcttta ctactcgtat 1011 atatagacta gcgcgctcgg acacaacaca gtcgaagcag ttgcatcatc atgtacggag 1012 ttgagaggtg gaaatatatt tgtttgaagg agggttctag accgcgatca ttgtttgatt 1012 tggccgcgtt agcgttaccg cccggcattc gcattgaaaa aatctttaac gaaccattga 1013 ttcgattaat taaaggagtg catggatttt tcttgtgtgt acgatgtgaa cttacgctgc 1014 agtatagcga aaatcgtata aactattgct ggcaatgtgc ggataaatgt ttgttttgcg 1014 aacgaacagg acgtgttcgc gtctgggacg atgacgctga agcgagaata tttaaataca 1015 acaacagact gcaggtatac gaagtgttat acgacagcga gcctaacaca ataaatttgg 1015 aggattacga aaattgtgaa gagaagcatg aaaatcatta cgtttttgac aaaatggtaa 1016 agctaatttg cgatcattgc tttgtcaatt atgactactg caccgcttgc cgggattatt 1017 tacacttcac taagctgata ccaatcagaa tttatttcgt ttacgacagg caagatccta 1017 tacctccga~ ggattttaaa agtttatgtg aaacgtgtgc attgaagcta caatgttata 1018 tttgcggacc tgaaaagcgc tttactagcg aagatataaa gcgttttcgc gacacgacca 1018 tacagttcat gtttgcttcg cttcggtcaa gaacggtgtg ctttgatcat gcccattgcg 1019 tgatatttag tcacccctac agacaggaca gtgattattc gtccgacgag gacaaccaaa 1020 cgttttattt gcatcatacc atgagaccaa tacaatattt accggaacct cccataacac 1020 1308 SEQ.LISTING.txt tacacgaagc ttctttattg agaaatccca agtcgatgct taatgcggta aaaaccctgg 1021 caaaacgcga agaggagaat ataattgacg cgcaagaggc agcaaaattg ctgtgcaatc 1021 tgccggacat agagcgtatc gacttgatcc gattattgat ttatgttttg gaaaataaaa 1022 aaaacgcagt ggtgttgaat gtgtacgaga gcactggtgt gcagtggata aattgccgca 1023 aatgctcacc cccggacgga atttggaaga atatgtatta tgtacaaaaa gactgctgca 1023 acgccattaa gtatatgagt tacaattttg atgaggatct cacaccaatt cttttagagg 1024 agacgagcta ttgcgcagaa tgctcttccc ccttgtttat gttgattgat gctgagcacg 1024 atagcgacta tcagtgcgat tgtgatgata tgtgttaatt tggtatcttt atgaataagt 1025 ttaacaaatt catttgttgg cttttaaaaa tgattttgtt ttatataaca tgtatcctat 1026 taaagtaata cagctgcctg gacaacgatt gttctttaaa ttgcgccact taataaaagc 1026 ttttggtata tcaaagactt taattgtaaa acgcgttcca cctcactgtt tggtaaaatt 1027 taatttgtta aaaccttttt gtacaaacga aactctttat ccttccacat tgttcatatc 1027 gcttcgcggt ttgcaatata ttaataatga tatattgcta aaatatttac aaaaaagcta 1028 tcaaactcga ggcctataca ttaataaaag ttaccaagtc gtagaatttg acagcgatat 1029 tgaggaaagc gacgaatgtg agcgagagta tgatcttgaa aagtgtacag tcggtgttgt 1029 agagcctaat atcgagttta taaaaatggg aaaaaggtgc tatttgaaag cgtgtgatgt 1030 cgcacgagct ataaactgcg cctctacata taatatcgac aagtttgtat cggacgaaaa 1030 tatggtgtta tgggcggact tgcgtgagtt tttaacaaaa aaatgtgaag gcttcgctcc 1031 cgcttactct agatggaaac aacaaactgt ctttttgaaa ataactggac ttaaacagct 1032 gttgttggct aagaatcaaa aaacactgtt cgctcaaatt aatttggcgc tgcaaaacta 1032 ttcttcagac cgcgcgccta tatacatcaa gcccacgtct agatactata aaaagaattt 1033 aattgccgaa cagtgtgtgg tcggtaagat gtacaactat atcgatttta taatgcttcc 1033 agacacaagc gtttggtgta aattgcgtat ggttcggaaa tatttttcca ttaaaacact 1034 acaagacatg agcatgtttc aagagtacac aacgacatgg tcggaaatcg atgcgctatt 1035 1308 SEQ.LISTING.txt aagaagcaaa cgtctttcct gtaatattaa atggaagcaa aacacttgtt taataaacgg 1035 agaggggtta tataaactat taagaaattt cgagctgaat tcacaggctg aacgttttta 1036 ttttgaaaca ctccatgaac ttaaaactaa attaaaaatt aatgtcaaag tttgatttca 1036 tacagttaaa agttgatatt ttaagtacaa agtttgattt tttaaagtac attttgtcta 1037 aagtttgatt gtttaagtgt aaagtttgat ttttttaagt gtattttgtc taaagtttga 1038 tttcttaagt gtaaagtttg atttttgttg tttttgttag tcaaattttt tgaatattaa 1038 gccagaactt ggcttttttc cttcttcccc ctgtacggag aagctgaatt ttgaagtaaa 1039 taaattacaa agatttggca acgccgattg gtctcgtatt agactttcgt gatttaataa 1039 aaaatcaaag tattgtcgaa aatcggtgcg cactaatttg tagtatccaa tataagcgtt 1040 tgtgaagagt attaataaaa taacaaattg agttatgtat ccttcatcca ttttaagatt 1041 agattcattg aggttgcaga caaattcgtt ggttatgaat ctctcgtaag gattcaccgg 1041 cgcagcatgc tctgttgatt tgatccgatc aaacagtttt gtcatgtatt cgtttttgca 1042 gtcgttttct tcaaaaacaa cgttgacgtc cacgggcttc tcaagtacgc gcaatattcc 1042 aggccggtcc acgaaacaca ccacagtctg gtcgtcgtcg gggttgatgc tacgataaaa 1043 gacaatgggt tcgccgggga ttgcaaactt acgttcgcta gttataataa agcgcatgtc 1044 cacaaaacgt gtactgtgcg gaaacatctg tgtattgaca aaagctagcg aatgatacac 1044 aagactgaga atagcctccg gcgttccgtt tgagccgaac aaaattttca aatctggcag 1045 tttgagatca agcaccatcg cgacgtactt gctgagcatc aagtacattt ctcgcttctc 1045 ttgctgacgt tgataacctc atttttatta actaaatcgc tgacgtcata acgtttcgag 1046 taagaatttt cagcatcggt tatttccgtt accgtcctgt aattctcaac ctttctctct 1047 ccctctcgtc caattgttct tgtacggttc ataataaaat gcaattctta tagacaaatg 1047 aagtttatta aagacaatta tagaaattta cacgttatta aggaatcact tcggtgccca 1048 accacaatgg tctattgacc acatacactt catatccctg caaaccttct tgcctgcgtg 1048 tcgctcttcc ttcgaattct accactgttc taacttggaa tctcggctct cttaacggat 1049 1308 SEQ.LISTING.txt tagcgaggaa gcgcgattta gtgggattgt ataagttggc ggcgaccaac ccgcgctcgg 1050 gcaccaaatc acaagtgggt acttgtgcta acaacaattg agtgttgctt acggtcatag 1050 tttgaggtct caccgttagt ctaatcagat tctttagaaa cggcggcatt tggtcaaaga 1051 ccgcggtctg cactccattt cccggaggat tgtcgaagct tctgatgtct cgtataatct 1051 ctggtctaca atagatggcc ggattaatca agcccataat atgactcact accgactgta 1052 atttggcgag cacgtcgtct gtgtagtatt cttggctgac aagacctcgg cacagttcgg 1053 caattaagtc ttgtcgctcg tatatactat agaatacaaa cttttccgtc gctgacatgt 1053 tttcaacttg caaataggtg agaaaattgg aaggtaaagg gatcatgatt cttcgagcgt 1054 cttcggtgtt ctgttgaatc aacgtttttc cgattaacat gtcgaactcg ggccccactc 1054 cgctcccaat tcgtaccacc attttttcca ttttaaaata ttttgccaag tgatactgac 1055 aaatgaacgt accgtcgtcg ttgtatggct gaatgcatgg tggttcgtag ggtcgacagt 1056 ttaaaaactc tggtggttga acgccttgaa agatgcaaag atttgtgagg ttacacgctg 1056 gagaattgaa attcattgtt ataaatgctc ttgtgactta taaatttaat aaagatggat 1057 gaagtagaga aggagtttga aattagttat acttttactt ttcctcaaga tatgctgtat 1057 ctgattaaaa acttcttaga taaacacttt tcaattaaag aggaatatgt agaggttttg 1058 gacaaaaata atgtgcgctc tcgtatattt atagatggga cgataaaaag tgttaaaaag 1059 agtgtcgtcg aaagtggtag atgtgttgtt ccactggtgg acggttttgt accaatgata 1059 gagcgtgagt gcgacgaaaa aatatatcac gaaagagacg aaaaaattaa acgtatttgc 1060 aagactaggg tttatcagcg aacgaacgaa ttagataacg ccgaaataaa atttgaacac 1060 atatattatg agtacagcga aggtgacttt ttagatccgc taacggctaa caaacaaatt 1061 gctttgtata atcttctgaa acccaccgag gagataaata cgaccaacaa ctctcatttg 1062 ggtagtgatg aaattttatg taattgtaga gtagagtttg agtatgataa aagacctgaa 1062 caaaataagt taattcggct agccgagctc attcaataca tcgaatacaa tcttctggtc 1063 gacactgaaa tacaaccgtt tttgtctcac acgaatatat ttaatgaaat tatgtataga 1063 1308 SEQ.LISTING.txt tcttttacgg aagagaggct tattacagat aactgtagcg atgtggtgtt atgggcttta 1064 aaattggacg ggacgcgagg taaaggttac gtggtaaacg ataacactct gtttattcag 1065 ttggatgata tgcaaatgtt ttccaatgtg ttggagccga ttcttaaaaa tgattccgat 1065 accggctcaa aaaagtgttt tgaaaagatt tttgggtcgt atgcaacaca ccagtaagat 1066 ttagctccaa tagattgttg ggtgttcaag tggaatatgt ttgttcgaca aaaacatttt 1066 acgtaacaga cgtcctgaac gtttacaaat acacatacga taataaaaat caatttgatg 1067 tttcggcacc ttatcacgtg aacatttatg atgcaatgaa ctttatgaca acatcttgtc 1068 gtaaagagtt taaatacgga gactatattg taaaatttca acgcttttat ccgtgtcgta 1068 aagatgtaga agaaattgat ttgaacgacg gttatatagg tcttttacaa gaaggagata 1069 ttgttaaaat taagcactgc aaatcttttg aaatgaaata tatgggtaaa agtgaattta 1069 taagtactac tggtgtgttt aagactgaca attgtattgg tttggaaatt ggaagtatat 1070 acgaagtaaa aatgtcgcag ccagacgaaa ataaggtgtg tgtaataaaa aaaagacccg 1071 atcgcttgct attcaactga tataaaagtc aacgctcgtg ttgctgataa acatacgcct 1071 tccctcacac gccgaagaca gaccacacta tggatactga agcgatgcct gcggtgattt 1072 tgaagtccat tcaagatgaa attgaaatta agtgccaaaa gtgtcgtata ttattgtttt 1072 gtcgagagca tatggacgat tacattttgt tgcaaaaact tcgaagaatc tccttgaatc 1073 agagaaaata taaatcatca ttaaatgttt tgaaagaccg tgattttaag tgtaggagga 1074 aactggagtt taattaaata tgtatttata ttaagaactg ctcttgtttt attaaaatgc 1074 catataataa tgtctctgac cttccatcca gggtaaagaa ttcgctacct tatcaggcgc 1075 aaagaatgta cttgcgcgta tataactctg ccatggatcg ttacgagaat ccgagtcgtg 1075 tagcgtgggg tgtggtaaaa aaacactaca caaaactaaa agatggtaga tgggttcaaa 1076 gagacgaagc gctcaccgac acatcagaca ccaccactac cgacgacgat gaattttact 1077 aattgataat gcctagcaat tttttgtata gagtccagtc catcttttga aatttgttta 1077 acttatcatt gttttgttgt attggtctgt agctgtttac atggttgtga aacagcatag 1078 1308 SEQ.LISTING.txt actcgtaaac taaatgattg gtgtataaaa catttttggt ggacatgctt ctattgtact 1078 cttgtactaa ggtgaggggg tctcccattt tttcgttata cagcgccact tcaacttttt 1079 ctacctcgta cggaaatgag ttaatagtga gaaagtgttt ggcgcacata ggacagaaga 1080 ggacaataaa gatgttgtaa aatatccatt tgatgttttt gatattttca cgaaccatat 1080 caatgtccaa gctatcgcga tttactacca tttcgtctgc gatcaaacaa ataaaatgaa 1081 tgctgtccca gatggtgcta aaagagaaca taaattgggg cggtgtaatg ttttctaaat 1081 taaaatttag caaagcctcc gtgtacatgt ctttaaaatt atccagcttc acatccttac 1082 ctaatgagac acaccatgaa ataagttttt cgacattttc ggctcgggga tcaccgtaaa 1083 cggtcacaca aaataggtga taaagaaacc taacttcttt aatcaacaca ctttgtagtt 1083 ctttcgaagg agccacccgc gtcatgtcta acattctata tatgaataaa gcgcagcttc 1084 ccttgtacct aatgaccgtg ggcgtttcta ccaacattct tatagaagtg agagtatgct 1084 ctatttttat gtataagtgg ggcgagtaac aaacattcgg tcaatggcaa ccctgaattt 1085 gtatacgttt aaacccaacg tcttatgtct cgacgagagt gatgaacgag aagaaatgta 1086 tattcaaggt atagtggagc tgtagaaaat caaagctgcg acaaattggc gtgctttcta 1086 gaattaaaaa aagagcaggt cttgctactc aagagattat cagaccatat tttaaacaga 1087 acatcgggca actattttag aaaccatgtc cttctggacg ttctagttat gtataaaaag 1087 tataatgaag aattcggtga ggatacggct tttgggaacg aatgtgcgca actttgtttg 1088 gagattgttc aactaatgta cgagctgttt agttgcacta ccaatattgt tgtgctgatt 1089 gaaagcgaag ctgacccgga ggatgaaata aatcttcttt tagcgcattt agaaagaagt 1089 aagtatattg cgacagaaaa ggtgtgtaaa tttggaaaaa caccaagact acaatttagt 1090 atataaaaac ttcataaatt ataaggaata aaagataatg tttggtgcca tcgtattatt 1090 gttggtaatt ggcgctgttc tatacctatt gtacagtaat gataaactaa acggagattc 1091 aattaataac tcatctgacc aatcagggga ttctatggat tcgttgcagg tagaaaaaca 1092 aaatgctaat aatgtaagaa cgatatctcc aaaccgagtt aaaaatgtac gcttggcgca 1092 1308 SEQ.LISTING.txt cggagataat ctctttagta aattaaccgt caccgaggca ccaatctctt atgatcaagc 1093 ggttaatcac ggcgatcgtt taggcgcaaa taccgtattc ttgggcgtgc tggaccagcc 1093 tttaggtggt ttgccaaatt taaatagaca gaccgctaat gtaacaataa agcaattcaa 1094 aaatctattt ataatgttta aaggactgga ctttgtggag attgataaca acaatttaat 1095 ggttcgttat gaggtgggta gcctagtcta cgctcttatc gatgcatcaa acgccaccct 1095 tccagatttg ttgcgcgacg tcaactatcc tatcgtagtt ctcacaaata actctagtgc 1096 tcagctagtt cttaaagaat ggggatacac tcaaataaat aacagcggaa ctctctttgt 1096 taaaaatgaa aaaagtttta ggttgcaata aaaaaagtat taattaaata aattttattg 1097 taaacacaga aataattaca tcatatcatc atcaatgttc gacttaaact taggtctatc 1098 tttgcggaaa tacttttccg acttggcaat ggtcaagttt tcataagagc acgtgtcagc 1098 gttgaagaag cgactcttgc cgtacttttt acgaaattca ccaaaaagtc tactctcatc 1099 acagcgctcg tgcattttgt aatgaaccat atgcttcaca atgtttacac actttgtaat 1099 catgtctaaa agaatcgctt cagtaaaacc cggcgcaccc tttacctcct taatatctaa 1100 aacatacaaa agcgcttcaa gtgtgttatt gtagatatat agacacttct tgttatgctt 1101 gtaacattta tccccttgta gaatattttt gtaataaaca aacccagtct ttggatccga 1101 gttgtaataa agaacgtttc ccagaaattg tgttactggc gaggtaagtt ttgagttgat 1102 gtcctttatt tcatggtacc ttttacgaat gtaattttcg taaatgctcc cattaaaagg 1102 ctcaatatcg ctctcgaaac tatggtcaat gtaaatttga ccaatacggt tactgcacgc 1103 cttatcgtaa ccgtctcgaa tgaaaagcat atcgttatta gtgatcataa ctttgtagtt 1104 ggcacaaaag tattcttcgg gtccatattt cttgtttgca aactcaaatt tggtgctgtc 1104 tgcaatactc tttaaataac cctttgacat tatttccgcc tcgttcatta tgtacaactg 1105 agactcaaat ctcttaattc ttgaactctt gtcctgattg tttaaatcat atatgtgcct 1105 gtcacacttg taaactaaaa taattttatc tagtagttcg aacagagacg atttccgcaa 1106 ttgggctcgg aggtgatgac caaacacatt ttctcataat ctgttggaat ggcaagagac 1107 1308 SEQ.LISTING.txt gcgcaaaaat tgataatcgc tttggaattg gtgatgttaa aatttgtcaa taatctaaaa 1107 tagcaaaaac cttgtataaa attgttcaac aggttcttgt ttgtagtttt caaggaaagt 1108 ttattaagat acatgcgcat ataaaagcga gtaagccacg aatacatatc gtcgttgagg 1108 ctatcaaatt ctatcaatct atctgtccat atgttgtatt gaagagggat ctttttcaat 1109 ttgttaaagg ttaaattaat tttcttaacc actctattgg cttcgtacaa ttttttggag 1110 ttagcagaac caatgtttag atcttgcaca aactcttcca cttgatccgc tacggtgtta 1110 tttaaaaaca tttctgcccc attaaggcga atgtaattat gtagcttttc aatgatgacc 1111 tttttgttta gaaacaaact ctcttgcaaa agaattggcc tatcacactg ttccgcaatg 1111 tctagaaatt catcataaca cgttgctaaa tagccccata tataactagt aacagagctg 1112 ttgggccaca aaagttgtaa tgttacagcc aattgcaaac acagtaaatc aatgtcttga 1113 ccgcgtgaga tgaaattgtg taaatgatca ttcaaattta acttaatcat caacattact 1113 agatcactat gatggtaaga tagaacgctc ttgatcatta tttttagttt atccatcaac 1114 ttgttttgaa catccaacag ttttccgtcg agcatggcac aatcgcgaat accatcttta 1114 gttagattaa aatcccgttc aaactttttg gcgtgatacg ccttcaatag gagtatatcg 1115 tttttcatag cggcaaagat ggcgtcaaaa gcgcgtctgt caacaaattc ttgatttttg 1116 caaataaaat ttttctttag agaagataca atcacaaaag ggcagggttc tatgaatttt 1116 tttttgcaca catcaaacat cccgtcttct gtcatgtaaa aattgagaag atgattaaat 1117 ttcaatgtgg ttgtttggat ttcgtcagct ttttcataga gacttgctat gtcgtgctct 1117 tttttgttct tgacatattc atatattttt ccattaaaaa tataactgac ttcgttatct 1118 ttaatttttt taaagaaacc aaaacttttg acagaatcgt ctaacttggt cgtttttacc 1119 aaggaactgg taatgttcca ttcttcggtg tttttaaata tttcaaaatg tatcgcaaaa 1119 taatatccca aagctttttg aggctcagta aaaaatttaa ggctcttcaa aaattttttg 1120 gcgctatctt tagatgcaac gtaaataaaa ttctcttcgt acaaacattc catcttgcgt 1120 ttttcttcct cgtcaaagtc ttcgtctcga tagtttgcaa atccgagagc gtgcttgcac 1121 1308 SEQ.LISTING.txt aaaagcatta aaaacaaaaa aatgtcctct tccttctcct ggttttgaaa tttaatgtgt 1122 gacgcgcaat acttccagac atttataatt aaatacggaa aagttctaaa ctcgctgagt 1122 tccaaatatt tcaatagaaa catattctca ccaaagtcgt tgctgggggc ggcttcgcac 1123 atgtaactcg cgatctcatc aaaacactct ttaatgtaac gatcaaagtc ttcgtgaaaa 1123 tttgaggatg gtgaaatttt gatgtcactc ttagcgggca aaatgcacgt ttcaacgggt 1124 tcttctccat cgtcggtcaa aaaaacttgt accgaatcgt agcgcagtct gttcaaatca 1125 atctctccca aatacgcaaa cttatcggta aagcgacacg ctaccactag atcgttgttg 1125 acgagataat tcaacaaaat ctggtttttt gaacccacat aatggttacc aaacttgagc 1126 tcaacggtgc gcacactgtc ttatgattga tatcaacatc catgacgtga tgcggcgcgt 1126 cggtatgagg tccgttttga aaccatcgtt tgtcgtcgac tttaagagag caaaataaat 1127 caaagttgat ttggctgttg ctaaataaat ttacaggacc caaatcacga tgattgaaaa 1128 gtggtatgtg cgcgcttagg gtgatgttgt aattaatttt gaggtacaga agccagccca 1128 aaaacctcgc gctcatatta ctccaaacaa catatttacc cccaaagacg atgtcgttgg 1129 cgctaccgtc cattaaatcc ttaaagcacg gtagttttgc ttgattcaac aggcgctcgt 1129 aatctgtacg cagcatgtaa ggtttcactt tggtgttgta aaaatttgcc acgtgacacc 1130 agtcgtgctc ttctgtcgct gcgcaggtca gtagctccac caaaaaatcc atgtctgagc 1131 aatcctttat tttataaata tcgctccggg cgttataaaa tagccagtga ttattgaaga 1131 cacaatcttt tgaagtaggc actccgtgcg tttggtaaga atttagtatc atgtttatgg 1132 acatagtggt tgttcctctg ttgtttttag ctattttcgc gttactagta atcacacttc 1132 tattcaatcc tgtcgaagat tttgctgccg aaatggtaga ggctactgtt gtcaatgttt 1133 tgcccttgat taatgttttt gaaaagggta acgataggct ttttgtaatc gagcccgaaa 1134 agagtgtgat atataatacg cacggcgctt tatattatta ctttgaaggg ggtgtgagtg 1134 gacgtctatg tccgcacaac gaatacgctg tagtgcgaat aacggcagcg gacatcgagc 1135 taataaacga aaccggcgta tacgatatct attgtagtcc cgtgggatcg agaactatat 1135 1308 SEQ.LISTING.txt atagccattt tacatctgat tcctttagat atcaggctat tttacccaaa atgacctata 1136 cccttctgga tgttttaaat tatcttatcg aaacgggttt tgctctggtg tattgagatt 1137 acgagtcgcc atggaagcaa tcgtattctt taagataacg cacaatctca gagtgccaca 1137 cgtgccagtc ttggactggt tcgggacaac gagttaaatt aacgaaatta tcataatgaa 1138 tattattgtg gtgcaagtca tccactaacg ttatggtttt tataaaatta attccttttt 1138 ctttgagata atgcaaaatg acgcgaggag atttcggaag gttgtggggt tgaacgttaa 1139 gataaaacgg tgtgctttta tatactattt cgtagcgtgt gtctaaaccg tcttcaaagt 1140 ggtaatcgcc taactttcta ccttcggata aaacaactaa aaagtaatcg tacaagttta 1140 attttttcaa actctccacc acatgacgcc tttcaccgta gctccacaaa caaagaacgc 1141 aattatttct ttttaaaaaa tccaaacttt cgtgtataaa gggatcgcgc aggcgcacct 1141 cctcctcttc tgttataaga gttgagtcca tatcgaatac aataacgtgg ggaggagaaa 1142 acatttgcgt gctgtttaaa tgattcactt cgtttacatt taacagtagc cattcttcta 1143 aaaacttgta tgttgccgga ctctcataag tggtgaataa atggccgaga taggagattt 1143 gatatttatt tttaagttga tttcgaaagt cggtcacgct atcgagagaa gttattgtat 1144 ccattttgta aattggtgag aagttgtgtc ggacaacgtc gtcggcgaag actacaaatt 1144 ctattttgtc aagtgcgcac atttctgcaa agcgtacatc tgagtagcga ttcaatatta 1145 agacatgtcc cttaacggag gcccacttat tgcgcaaaac gatccactcc atttgagaaa 1146 aatattcgat atatttgcag actttagacg tcgggaggac tatagcggtc ttgtgaacac 1146 ttaattacga cttatccgga aaatgtcaag aatcggactt ttaacttttc caatacgggc 1147 catacgttcc acatgctgta cgcgtatgtg ccgtcgctat ccaacaagga gcgaaagcaa 1147 atacgattgg acggtataaa aaagttaatg aagagcacca gcaacctttt tgccatgtat 1148 gaagatgtgt ttaagtgtat gaaagaggga ttaatagagg aatcctgccc ttgtgttgct 1149 ataaaatctc gtttgcagga gaacattgcg tataacgagt ggttgtccaa taaaaatttt 1149 gacagcaaac ctctcaagtt gaaaaaagat cccatagaca acattctttt caagtacagc 1150 1308 SEQ.LISTING.txt gtcaactgga aacagagctt aaaaaagaaa aaaaatgttg ctgtaaaaaa tgaagtaaaa 1150 ataaaaaagt gtgaagtaat aaaaaaagaa ctgttgtgct tcacgacctt agctaaaaaa 1151 ctctctcctt cttcgctaga cgaaattaat gggcgcaccg ttgtgacgtg ttcgcacgag 1152 tttacaatac aagagaaaca gctaagggcg ggggatgagg ctgtgtcttt tgtgaatgta 1152 tgttcagtgt gtgggttggt gaaaaaagaa gaaaattagt ttaccatagt aaattatttt 1153 ttattaaaca actatacata ttggttgaca tggtgtgagc cgtaacggga tcgagaccgt 1153 cttcttccgc ccgatcgaga acgggaccga gagcgcgacc gccttcttcc ggacgatgcg 1154 tattctccgc cgctgttaga tcttctcctc tgtgaacgtc tcctacctgg cgaacgagat 1155 ctacgtcttc tgtacattgg tttgttggcg gcgaaactac cttatctatt tattcgtcgt 1155 ctgcaaattt tttagattta tatcttttga tttcagaagt agtgctcgtg gtggttttag 1156 atctttttct ggtcaccaca tctccaattg caaccttttc aacgaaatta ttctttccac 1156 tttcacgtgc gcgatccata attcgaaatc gccgattgta gtcggccaca tcaaacttaa 1157 tgttctctga agcgcactgc tcaacggtgt ttatgaaaat gttgttaata gcgttgaaaa 1158 ccatgcggtt catgtccgaa ctcttttcaa tattaatggc tatattttca atgatgagcg 1158 ggttattacc aaaggagaag taattatctt ttgcgtccac aatgtgttga accttctgcg 1159 agaggagtag ttgaaattta tcaacaaacg ctttacaggg gtccgtaacc ttttcgtaca 1159 cattcatgtt tgtgatataa tcacgcactt taacctgtgg atacttgtta agttcggcgc 1160 tggtggtgcg ttgtagtgaa acattaacgg ccattaaaga ttcataatct aatcgaatgt 1161 ttgtgatacc ggtcaagtct cgcagattgt ctaatataac acttgtcgcc tcaccctcta 1161 aaaccggtac acactctttg tctttgcgga aaagaacact ttcaataaag gagaaaaggt 1162 ttttgtattt cggtgtatgt gaaagaaaca gatagagcat tattaagtct ttgattttaa 1162 aacttgtcga tgtgacgctg gacgagacaa agtagttcat aattttttct gcaaacgaag 1163 catatttttt cacgtcaagc gttacggtca cggggctggg taaaagtcct cgccgcagcg 1164 gtgcccgcaa ctggtttcgt gtgctatccg ttccggcgtt cccatacaag tactgcgaat 1164 1308 SEQ.LISTING.txt aaacagcacc gccttgtgtg attatcaagt tttcagcagc aatggccgct tcgttaatta 1165 gttcgctcag aacgctaaga tcaacatcta tagtggtagc gtcgccaagt aaaggaaaga 1165 attgttccca aaacggaaac ctcatttgcg cgtcgtccat tgcattttta agtttttcaa 1166 tcgtcaaaaa aagtcttgtt ttagcctcat tttatactgt tgaaatgtaa attacagtta 1167 tattataata atctaaacac acactttctt acatcatacg cttgtagagt cttgtattac 1167 aaaagctcca ttgacaatat caatgagcac ttcgagtgtg tcaaccgctt catcggctcc 1168 tcgtacgagc agcttctctc tttcttcatc tattccgtct attagacgct ttagacctct 1168 tgtttttgga aataaacgct gcagtacacc ttttttacca accgattgat cgtttcgaat 1169 tatgtttccg acattttgct gcagtaacgc ttgaagcacc tcttcggatc catcggtagg 1170 cgcgtttggt gcgataggtg ctggtgcggg tgtggtaaat aaactatttt ccataatact 1170 aagccaatga aacggtcttt tgcaaaagtt tgctaacgtc tccttttaga ttgtacttat 1171 taaaaagtct taaaacacac tcctttggga ctacaaggtt ttggcacacc tcgattgcca 1171 actcgccttt tataccttga agcttttcta taaatgtttc aaattccaca tcgtcataat 1172 ccttaaaaag cactctgcaa atatttcgag tttccaggtc gtacacgtca accagcaaac 1173 cgtccgctgc ttcattaaac tttcttttcc tcttctgatt taatctctct atattacgcc 1173 gttttgcctc caaataaact ctaaggaaga agccgataaa tattttatgt ataagcttac 1174 cgatttgttt tgtgctaaag tgttgctcca taaattgttt taaagggttg tacaatttag 1174 tgttgtatgt tgtgctattc aaattatgca gcatatactc caaagattta tttgaaacac 1175 ctctgacata gtcttgcgta tgctcaatta ataagttgca ctttttaaaa ttccaataca 1176 ttggagtggc tttatcgcat agcagattat aaaaaaactg taaaagaata ttagtgataa 1176 tattatccac gctgaacaca tctttgtcca caccgctcat gtcgctcttg aagagcgcaa 1177 aaaatagtaa tggaataccg agcatcggac ggaagaacac atcccagccc tcctgaagac 1177 tagcgtccat tacgctcaat cctagcgaag cgtaagtggc tttacatttt aaacagacaa 1178 gtttattagc gggacaagtg tcgcatacaa tagtgctcac gtctacatta ggtattttgt 1179 1308 SEQ.LISTING.txt gaagatagct tccgatgctt ttcataatta actgaaagct gggcacttgt ccaataaaat 1179 cgttttctat aaagagttta aaaatttgct tcacttcttc atcggtatcc gttcgcgctt 1180 cataatcttt tttaatcacc tctataacat gtttatactg actgaaaaat gtaagacgtt 1180 cgaatgaaaa gagatgctgt tggtcaaaat attctgccaa caaaaaggcg acggtgtcta 1181 tttcgctaac atttaaagag cagacaaagg tcaccaaact attttggact ccggcatcgg 1182 taaccttaaa aaatctaagt gtgtattcaa tgtcgtgcgc cattaatcaa ttgagaaacg 1182 acgaaagatt gttttggtta agtagacagt cgattgatga atataatcga ttgttgcaga 1183 ctaatataag tgtacacaaa aggcgtgcgc cacgttttgt tcttaaaatt gtagaatggg 1183 attatgaact gttgaagaaa gagctgaaaa aatatcagca acggcgctta ttgaaggtaa 1184 aagtgctacg tctagttgag cctaaaaaag ttttgaaagt aatcaatgaa atacacgaaa 1185 attctttgta tgctctgtcc gcgcacaagt ccatagcctt taagacttta aaaaacgaat 1185 ggtctcgaga aaaacacaat tatgaattat taaaatgcgt agtgcgcatg ctcgacagag 1186 gcgaattaga ctcttttgta gaaggtgtgt tggcgctgca aaaaaacgaa tatagtacac 1186 cagcagcgaa tcatcagacg agggtgacgt aaaaaaaatt gacaagggtg tgttattaaa 1187 aatagtgtgc aataaaaggc caaaaatttt tgaaaagcta gaaagtcgcg aatacgaaag 1188 cgtttctgat tgggacacca taatacatgc cgttgggagg tactgcgttc ttgaaaccaa 1188 aaacacgctc gaatctctgt ttattaaact aattttaaaa ttaaataatt acaccagcac 1189 aaattgcaca aaatcacaac ttttggagga tcttcgaagc ggtctcgaaa ggggtcaccc 1189 taaaattggt tcattgttga cttgtcgacc tttacgcaca gacacctgtg ctcgttttat 1190 taaaaatttt gaaagatatg gagtgctgtt taagaaaata ccaaatagac tggctggacg 1191 ttcttgaaca cgatttaccc cctccaaaaa ataatcacca atctagtaat atttacccca 1191 accttcttgc ccttaaaacg ttatcttatc aggacgttaa ccactattgc agatcggtgt 1192 ttgagcgatt ctgtataaaa ccgggacatg agaacgagcg ggcacagtca catgatggat 1192 tctgcaatgg aaactataac tacagttgcc attctcgaca acgacgattg gcaggcaaag 1193 1308 SEQ.LISTING.txt ttcatcaaca agctgaatga gaacactaac gcagtacgaa cattggaatg cagcaaccgc 1194 ttcagtcttc acaacgcgtt gttgtctttt aaaaaaatgg cgccaatcaa aagtttggag 1194 ctgaaacgag accctgttac cggagaccta ataataccgg aaaaagtgaa gatggacaag 1195 atagagcgta agaacaagat atgctatacg ataggcctga gtcgtttagg aggtgtgaat 1195 aaatgctatt attgggacca ttgcattgcc aagatatgca agagcgctac ggcaggaaag 1196 tttcttgtgg ttactggaaa atttgagccg gtattaatgg acgttgtaga agagatgatg 1197 ggaaagtact ttaaaagaac aaaaaagcag caaaccgacg agcctataat attatccggc 1197 accgcggtca cccatgtacc gtctatgggt gaagtggaca aatggcgtca attcttgcaa 1198 aagttttttg tactagccaa cagagataac tctgcaaaca ttgcaagcaa tgaagtgaaa 1198 gaaaattgta tgctgcatcc catgagtgag aatttcttta gatacgtctt tggttcgttg 1199 gaggatagaa acgttggaaa tcaagttgaa tgcaccgtcg gtttggtgtt tagcagtgtc 1200 gaagagatgc ttgcaaagag aactgtgagt tctttatcga caaccgaaga ggttaaagaa 1200 agcgctttta ctcttagatt ggaacccgcc attgttatat atcacgatag actcgatgag 1201 tatgtgaagt tcaaatgaaa ataataaata aataaacaat tatgtcaata taaaattttt 1201 tatttataat gcaacacaat gttaaactat acactggtca caattacatt tttcccttgt 1202 ggttaacaaa acaactgatt ttatatatgg gaggagagaa atatgttaat atgataaact 1203 ggactagaag tacacgatat tatcttattt taaagaaggc atgctactcc aacataattt 1203 caagcttacg attcttttat ccagacggtt gtgtgtttag agtttttact gaaaacgaaa 1204 ttaatacaaa cttttaacgc ggtctgcttt gacagtctat ctcgctcagt ggttggcact 1204 cgcgtgtttc taaatcgaaa ccctgagatg tgggacaagt tactagttcg ccgaaacagt 1205 tataataacg acggcaacta gtcgaatctt ccatacggca cgcaattaaa tctatagggt 1206 tctcaatctc ttctatttca aacaattttt ctaaataggt atacactata taaaaaagcg 1206 caataagtag aatagttttg aaaacagcct aataactttt ttcattgtct tataccacac 1207 actgtttaca aaatgcgggc ttgcaaaaat tgcattcata cacgctctta cgtctatgtt 1207 1308 SEQ.LISTING.txt ttgcaattat acccttttgg gtacctcttc gataacgata ccgataaggc tggtcgagat 1208 ataaaggagt gccgcacata aagcagcatt cttcaacccg accgcagtag tcgcacagac 1209 gtacggtgat tttacaaatc attattatgt cgaaacgggt tgccgttcag gaagagacgc 1209 cggagtggtg cagtaaaatt acaagatttg atgatgaatc gctcgcaaat atacatacac 1210 tatgtttacc atccgacgtg tgtcttgcat cagatgatta cgagtgtgcg gaatttatac 1210 ctcagtccta cgttttcagt atggaaaaga cggaagagtc tatgtgtgat ctagtcgtcg 1211 ctttggagaa aggacctgat ctttttggaa ccagactgag tttaaagagt ggttctaaaa 1212 aagtttttga ttttgaatat gctcaaatat tgaggttaat acttaagagt aaaattaaaa 1212 gcgaaactgt tacggtgttt tacgtcgagt cgagtgatgt taataattta gttattaaac 1213 aataaatcgc tgttgtaatg aaatttttta ttaaatatga ttattcctat ttctcttctt 1213 tttctttcgt cgatttttac gaccgcacaa tgcgcaacct ctcttctaaa aaccactgcc 1214 ggtaaatatt tttgtgttca aggatcaaat gtagtagtta gcactaaaac agacaaaaca 1215 tgttatttag cacatttttc gatacatgct catgaaggtg gtttagtttt aaattttaaa 1215 tatgaatccg cttgtaaata catgtgtatt aataggtgcg gggaattgta ttacgacgag 1216 atgtatcata ttgaagattg taaatttact actatggctt ttaaagagtt tgattctctc 1216 tctgtgaacc gaggaaacta ttctgatttt attgcttttg cagattacaa cgcgctcttg 1217 tatagtttaa aagatggcga tgtattgggt aggggtgaaa catatttgaa aatgtctctt 1218 gaaaaaagcg gcggtgccga gtgtatattg ggtaatgttg ataagaacac taaaataaca 1218 aaaaagtgta ttgtaaaaca aaacttcgac tcaacccctt ttgatcggca ttcaaattat 1219 aatttttctt tatgggaaaa gtttttgatc atgatcaatt ggttcaggat agaagagcca 1219 aagagcgacg gtttaagaaa aattgactat aataaaaatt ataatgcaga ataatgagga 1220 tatgtgccta atactacacc agcgttcgca taatcattat aatgatggac cgtttgacca 1221 gttgcaatca tcacgtacat tctaaggttc tctctctgcg taaaatgttc tgtcgtcgaa 1221 tccgcaaatg tgtcaaaatt agcatttaca tagtggacaa cttgaatttc tccatctctg 1222 1308 SEQ.LISTING.txt tataatgttg gccgcccgta gcacataatt ttaaaagctt ctaaacgcat tggtaacaaa 1222 aattctcttc ttgtcgtgaa gaagcacgcc attccagcct cgacccagtt gaaacgaaca 1223 acacactctt ctttcatttc ccacatacat tcaccaacac cttctctgaa acagcgctcg 1224 taatcctcaa agtaacgatt ttctgttgta gtatacagtt gatatacatc gacctgtggt 1224 atccgatgag taacttgtct aaaagcgcta attgtaaatt ttattataaa gttacgttcg 1225 tctatagggt taaagtctgt acctccgtac ggatgtggat gctttttttg tcgaagaaaa 1225 caaatttttt ggtaattcgg actaattaaa tcaagttcgg tttgtataac aacatccata 1226 tcgcaagtgg tttccgctcg gccccaaaac gacttgacgt cggcatggaa aaattttctt 1227 caaaccgcag cggttttata catgcgtttg gaaaatctac tgtaaatgga tgtccggtaa 1227 acattgttgt aggactgtaa acgggataaa gggaatcttc atagtcgcag acacaatacg 1228 ctatctgtgt tttctccata taatcataaa actcgtacat gtaaccagaa gtcctttcgc 1228 ccgagatggg gtcaaacgaa caagggtcca ttatacatat tggaacgccg ttagtttgtt 1229 gtaggtaggt gttattgaag gcccaaaaat ctgttgaaat cataccattt gggcaaggag 1230 gacgagggaa aaactcgggg tctaatattt tgtctcttat tgtttgctgt ctacaatagg 1230 gtgtcatcga tatagaaatg tctgaaacat acccgttgtc acactcacat cttaatggtg 1231 atgcgttaat gtcggctatg tagccatggg gacggcatcc aaccgggtaa tcgcagtcat 1231 catacaaagt taattgggtt accaaaccag gatatgtgca atgacaaata agactaaatg 1232 tatcttcact gtaacgtcgc attatccata atccagtgtt ggggttacag ttacgtgcgc 1233 gctcgtcatt caaagcaatg caatatttct ctcccggttc tataataata gactcatctt 1233 ccccaaattc caaagtgatc tgttcgttaa actcttgaca gagcgctctg gtttcctgac 1234 ataattgaca atcggcattg cttgtacatt ttgttaacgg gggcgtgtga cactcgagag 1234 gatttggagg aatataaatc tcttcgggag gttctatacg cggaaccgaa gagttgtcgt 1235 agaattctaa atactttctc ttgttgttta ttcgtcgaaa cattgtcatg ttggcaccat 1236 gataagctat caaacatatc actatgacaa ataatataga tagtcccaac ccgagctgca 1236 1308 SEQ.LISTING.txt tcagacttat aaagtatgtg tcgtagtcaa caccggtttg tgcgatgtat actagcgatc 1237 aacttcttca aatttggacg tctgttaact acagagagga cagatattgg gcttttatga 1237 agagcgacgg tacgtggcgc cattcagatt cacagttttc aaaaacctcg acatataaca 1238 gttttgatca atttgagaag gctgtaaaat tgttggacgc gagggatata cacgttaaaa 1239 aaaccgtgag cggtggaaga gaatgggtaa ttgatgtgga ccacgacgac tccgatcaac 1239 so gcaagatacg ccttaaaaat gcaatagcac acgtcacgtt cgccgagttt tttggatcaa 1240 attgtgagaa aatcatgttt tccggaaaca gaggtcttca tatttggtta aatcatcaca 1240 agtttgatat gcaagcctcg gcgcaaacga gacgttatta ttataatagt gttcttaaaa 1241 agccaatctt tcttaacttt gctttacttc aaaaaggctc tttgggttgg tgtttcagaa 1242 atgcgcttaa agttccgtgg atagaacgtc aaatacaaca attgtatccg catattagtt 1242 tgaataacaa caaaatgttg ttaaaagagt tttatccata cgtcgacaaa caagtatttg 1243 aaagcacgaa acaaataaga gcgccttata gttttaacac taaaggaaga caatttaatc 1243 aaccacacat attggaatgg acagtctcgt taaatatgtg cgttcctact ggttcggaaa 1244 cgacagcaac agcaaagacg aagtaagaac aattttagat agatgctgta aacgtgtaga 1245 cgccgtagaa actttactga ccaataagtt tggaaaaatc gaccaagatc ttaacgaaat 1245 gaaagaagtc ttcttgaatg tttctttaat gctaaaacag gagcaaacag acgaatctgg 1246 ccaggacgaa gttgataaaa acagcccgcg tttatctaac acatcttcat gctccaactc 1246 ttcggacgga tctaatttgg cggtttatgt aagccgcgaa tcaatggtca cacacagcta 1247 cagtacgtga cgggtcgcac taaacgatac aacactcgta aaaggtttta tcaagacatt 1248 gacatgaaag aagttattgc cggcaaggaa agttcaccca ggaagaaaat tacaaaaatt 1248 aatcataaac tattagagaa agggactgtt gccaatattg gtgaagatag ttttattgtg 1249 gcgcatgacg ctgacaccgt atgtgatgtt atcctaaatg aaacattaaa acaataaatt 1249 tatttatact ttttattttt cttctttaat tacacacaac tctaccaacg catcatcttc 1250 tttttccttc gtcttcactg gttcgtttga caatttaagt agatcacgaa tttcgctcac 1251 1308 SEQ.LISTING.txt gatttcactc tttaaaacat ttagcaagcc gctaaaatcg ctcaaataat tatttttctc 1251 ctccaacttg tctttgattt cctccaaatt cttctttata ccctcaattt gctcattgtt 1252 ttcttcattc tggtctccca caagtaaatc gcgcaccaat tgccgcaggt ttttgtaact 1252 ctgcgcctcc gtttccggaa tagcggcgag atatttactt attacaatgg catgaataaa 1253 atttttgttg ttgttctgaa tcctgtacgc gggatgggtt gcgttccaaa gttgagtatg 1254 agagaggcgg gtataaggtg acagcaattg ggtcaccgcg tttacttctg cgtagccatt 1254 caccaaacct tcgtcgttag taacaataaa cacttcgatg ggaccggaat tgtattcgaa 1255 cgccatttca ccttatatat tttacaattc aaagaatgta tttaaagaca ccgtttcgct 1255 atccacatac cagtaaagga gtattacaaa aaaatttatt aaatcgttac tctcgtacaa 1256 ccgcttcact ttgtatacaa aattaaaaaa agaattgtaa ttgctgtatt tgtatgtggg 1257 taattgtcga ttttccatat acgaggtgta ttttttcaaa ctcattatgt cgagtttacg 1257 cttaagctcg ttgttaccat agcgctgttt actcaagtcc acctcatatt ggtaattgta 1258 gcttttcagc agttttatat tgtaactgtt tggtttttta cgcagagagt tgaggctgcc 1258 gcataagaag gcgacataca ttgtataacg atatattttg ctctcatctt gccactccaa 1259 aagaaaagga tccttgtata ttgagacttt gtcaaagatt aaaccggttt cttcgataaa 1260 ttcacgcaca gcagtctcgt aatccttttc gcccacatct tgtctccccc ttgggatgct 1260 taatttttcc acaaacggta tatgtttgtt gtactttaaa tttttattca cgcgctcgct 1261 gtacgatttg tttgcttgca gaatcaccgc tttgtcgtca ttagttatta aaagtaaacc 1261 ggaatgtctg ccttttttaa ccattttaaa ggtggtcaat tgactttgtg atgcacatta 1262 ccttatttat aattggcaat acagaacgtt ttactgaacg aacagtaatt aaacccttaa 1263 cccgttatct ttttcacgtt caattaatct ttcaatatta tctgcaccat tctcgcggga 1263 tcgtaagtac ctgtggtgat gcgctttccg taaacaaaat ccacttttaa atccatatcg 1264 ttatgaatta ctttgctttg agcggcggcc cttttaagcg cattacatct gcgagaattt 1264 agttctaatg gatgcataat gggagatttt tctaaagtaa acgaattaag acaaccgccg 1265 1308 SEQ.LISTING.txt tttactactt caagagcgct aattgtaaac aaaaagtaca gagtctcgta atcttcataa 1266 taaaaaacaa accgattttt taagcagtaa taataaaatt tcattgaatt ataaatatag 1266 aagacacaat tgtctaaata attttctgtg tcagtaataa acaaaacgtt aacatgacgg 1267 ctattatcag cggagatagc aaatttatgc atttttcact acttttatcg caactacaat 1267 caatgaggca aacgttatcc aatagttcgt tagtgataac cgtaaaattg ttcttcagtg 1268 cgccaattaa aactgctaaa ttgtttctat ccaactctaa catcacgtag acgcgactcc 1269 atttgtaacg tttcgtagta tccgcgacag attggacatt cctgagcatc ttctcgaaca 1269 acggatcgtt ccatcctcga cctttattaa ttttgtcttc gttaacgtga tgcttaaaat 1270 ctaaaccgct ttgaataaga ttggtcgtca tgcgtatact tagctgctgc ccgagtgtgt 1270 aattattttc gtaaccacgc tcccataaac agttttctaa aaatgcgaca agaggttggt 1271 agtgtttcat tacgagaatt ttttttaatc tatccatatc ccctttatac catctatctt 1272 ttagaaccat ttctaacaat tgtttacttg atgaagagag catccttgta tatttagagt 1272 attgcacgta gttctctaag tcttgaggtg tacatgtgtg cgcgttctct agtttaaatt 1273 ttataaactg cacactaaca tgtaaaaacc cttcttttat tataatacac cgcttcacaa 1273 gattatagtc tttggtctct ttaattctac acgataacca atatagtagt agatcgctaa 1274 ttaaatattt aacacactga ggaaaaggtt gagaaaagaa agtttgaaca tcacaaaacg 1275 catttgaact cacacactga gattcgtcct ccatatactt aacaatgttt attctacaca 1275 attatataaa ttaaacttta ctggagcgca cattaattat ctatgtaaat aagataaatc 1276 cgaatatgac acttaaagat ttgtataacg aaattttaaa gacacaacaa gacattgctg 1276 tgacctatgg tagaatagta tcgttagaga atgatttaaa aaagaagatt gacacggaca 1277 acaaatccga tactattgta aacagattag aagatctaca gaatcaagta gacaccgcgc 1278 ttaacctatt agaaaaaata aacaaaaaac aaagcgaatt agaacaagta gttgaagtgt 1278 tggaagatac aattaaacgt gacgaatcag accaacctca aacagacgaa cggcaaaata 1279 atcttttcaa taataaagaa gaagaagaaa acgtagaaaa cgttagtata gaatccgaag 1279 1308 SEQ.LISTING.txt aacaagttaa aagtattagc gcagattctc tagatacaca aactaaaaag gtacagtttc 1280 gctcaagcca aagttctaat agttcagaag agagcgaaat agaatctaca taatataaaa 1281 gcgcgcgctt ccaaacagtt gcgcactctc tcaaggatga tgccaagtgg tagctaaaaa 1281 tctttttaaa acttcccgag cggagacaat cggcatcaat ctcgaacgcg ctctcttcat 1282 actttaaaaa tagctctttc gcagcttatt tgtgttggac gtatattaaa tgactttgtt 1282 atgttgatgt tttaggtagc aaattttgta attgttatta atagatatga ccggaggcga 1283 taaagcaatg ttgtggtacg acacttacgg tttttctgtt ttgtgtgttt ttgatttaat 1284 tcaatttaag cattatttag aacaaattgc atttacggaa gacgaattag acattggacg 1284 aaccgtaaac aagctcgttg atactgtttg gaaagatgtg aaagtttgtt tagaagatga 1285 attaatgatg tattatagac tatgtcaaga ttgtggcgaa ataggagacc gaaacataag 1285 taactgtgaa caagtttctc ttaaaagtgt agtgtgtaag aagtgtggaa attgtctcgt 1286 agtacaagac ccaaggttta tttacgaacg gtccgacgca gaatacttgc tggaagaaat 1287 aaatgaaata aacaacaatc cgacagatta ttaaatataa agagagttgc tgtgataaaa 1287 aaacagtata tttaaaactt tacgatgaac cactcgaccg tgccttctct cgtgccgttt 1288 gacggtagct cgctatataa aagtacccac catcactatt gcggttttta tagcttgttt 1288 atcttagctc caataatcga cgacactgta gtggttgatg gaaaacaata caaattatct 1289 gaagagaacg ccattgattg ggcatacgac gggaccgata ctataataac ggaaaagcgt 1290 ctactttata cggagcatcc tttggaacca aacacactaa tttacaacgt taatcacgaa 1290 attgttggaa tattgctgcg ttatatggtg acgaaggatg gtgaatattg ttatgcgatt 1291 caagacggtt ttaagttgta caacaaccat ttaacggaca cgaatattgt ggtgagagaa 1291 aagaaaaaac ttattgtgta tgcggatcaa caatttgaca ctaaagaaga tttgatgaag 1292 tatctaaaag aagggaagaa aagcgctggt agaggagcca tattatatca taaagggggg 1293 agggacgccc aacttgtatt gtatgaaaat ggaagaaact tgagcaattc tcatcttagg 1293 cgtcgtgtgt ttggagtgct ttgatatttt taataaattt tgtttgaaaa gaagtgtgtt 1294 1308 SEQ.LISTING.txt atattattta tataagcatg gcgcaaccta ctagtttgga tttgatgaac gccggaaggt 1294 attcgtcagg tatacgcgac ttgcattaca ttttcaagtg gcgtaaaaag tttcctcata 1295 tctttacaga ttacaccatt agatatgcta caccggccga ttattacgta ccacccgctt 1296 tactatacaa gagcgcgatt gttgtagacg taaaatttag taaagagggt tgtgatgcta 1296 tgtcttgctt tccgtacacc gagacgggag tgattgattt tttaacaaca cctatcggag 1297 gatatactca aacttccgaa actgcgattc aatacaatca gcccgcctgt tttaacttag 1297 atcccgctct agcagcaaga aatcagcaga cacaatctat agaattgtta tatagaaaca 1298 ataaatgtat aatgggtgat agttttacga aaatgtattt caatagtcca tatcttcgca 1299 cagacgagca tatagtgaga ggcgtggacg acgttccagc ctttaacgca tataacgaag 1299 aagatcccgt cttcccggaa cgcgtgaaag ggcgttttaa tcaggcgtat tgtcgtcgtt 1300 ttggtcgtga ggaagagaat aattcgtgcc gccagcaatg gtgggagata cttgtgggtt 1300 ttgtgttagg tgacatgatt tatacgactt ttaaaataat gggaaataga gtgttggcag 1301 atttgcgtaa ttacgattac cgagcacctt ccgctcttct tccgcccaga aagccgcccg 1302 atggtgatgc gctattagcc ttttggttaa gtaggcgcga taaagccata gatggggagc 1302 ttgaagatgg atttttaaat tgtgatttta aaattacacc gcaacaggaa atcagttatg 1303 tcgctgaaaa aggctatacg gttcaaatgg cgagaacaaa atttgaagag gcggcggacg 1303 ttttaaacac aatgttagag gagcgctaca aagtcctaca tggttttgta aatgcaaaat 1304 ctaaaccttt gggcgcacca aggcaatttg ttttagagag agatccggaa acaagagaaa 1305 ttcgaaccaa cgacagtctc gagcacataa taacagactt tttagacgat cacaatttta 1305 taatatcgat tttggcagaa ttgggtttta gtatactgga ggatctcctc acggacatgc 1306 ttgttagttt aaataaagta ttaatacctg cattgagaga ttatttaatt aatgcctctg 1306 cccgttttac tgctaattta ttgggtaaca catataaagc aatggtatta gaatccctta 1307 acaggcattg atatccgcgg tgtcggctgt agcgaaagct ttggttcgag gtatatcggc 1308 ggcattgtct gtcattaata taattttgat ttttattaca atagtcgatt tggtgctcat 1308 1308 SEQ.LISTING.txt gttctgggac ccgtacggtt atagcatgat gtttccgcgc ggctatctgg acgatctttc 1309 aaacgccttc ttgggggctt attacgaaag tttagagacc ggctctagag aattaattga 1309 atttcgaccg atacacttct ttcatctggt agaagaagaa agcaatacta attttatggg 1310 ggaggagggt ttagcgattg gagattattt gttcaacttg gaggtaaata gtaacggcca 1311 aatgataaac tgggatacgg gcggcacaat tacggacttt gacgaagcgg atttggtggg 1311 agctgcgcta gctacaaacg atacttttaa atattttaaa tggtactgct cacggcacaa 1312 caagctagtg gaaccaaatc aattgctcga agcgagcaca atgatgggct gttttggttt 1312 agttcttgca ggcggtctct tactgtacac catggcggat tataaaaatt taactcaaaa 1313 acagtcggcg tctctgctga tggtgttttt aatagtgtta attgtttgta tttgctttat 1314 tgttctacca tctatacatt attatacaac actcgcgctg cacgatgcgc caaggttcga 1314 ttagattaca ttgcagacta tataaagctg cttggacggc tgatgaaagc attcagtctc 1315 tgtcggcgta cagattgtaa acatggacga tttttccgat tcatttgttg tggctgccga 1315 tttgaacgac agttgccacg atgtgcttgt tggtct 1316 <210> 2 <211> 2039 <212> DNA
<213> AsGV
<400> 2 atggttataa tattgataat tattatcggt gtgttgattg ttgcgtgtct aatatattat 60 tatttgtcgc aaattaactg gttgtatttg tttcctgaca ctttttccca gggaagacat 120 gtaaaaatat ttaatgatta ttttattaat acacttaatg aaaatttaaa taaaagatca 180 tataaagtca caaaacctaa ccgggcttgg gatcctgatc aaatatttga cgacgcctat 240 ccttggaaaa gtacgattcg attcaaatat gtatgttata cattaatagg ttactgtgcg 300 cgcttcgtaa attacgatga cgaactgtat cagtctccag atctggcata taatctcatc 360 actagccaac aaactatagc tactcatttg ggcacgacag cttctgttaa acctccatgg 420 ggcgtagcca cagattggta cgtgtttcgt gttattttgt tggaagcatt catgactatt 480 actgcagttc taagcaatac cgtgttttat ttagaatcgg ctcgcatcac atcgttttac 540 gtcgaactgt atctaccgtc tttagaagtt ggttttgt.gc gcaacataac ggacgtgatg 600 cgtatgggcg ttccgtatat gtacaacaaa ttgctgcata acgatttaat atcatctttg 660 gaaatagatg acttgagcgt gaaaaaatta atgcaaaccg tcagctcacc cgttgtggtt 720 cacggaacag gtttgcataa agattatata cctgttgagc gaatgtttgc gcgctcttat 780 aacaccattg tgaaagcata ttacactctc gattattatg gagtgctctt tcaaaaagat 840 1308 SEQ.LISTING.txt gtaaccgata tggagttgat taataaagct ttaagaaaag cctcttgtcc cgaagggttt 900 atacatcccg ctcttttacc accacttttt aagagcttta actgctcgaa tgttggtaag 960 ctcaccgact accctttggg gatccgttcg gcggattaca gtaaagtgtt gtcgaatttg 1020 acaaaagatt attttggcag taccgtcggt gctactccac gcttggcgta ttacgagtcg 1080 acccctcttc acgataagtt tggtcccgcg tttgcgatgg ccaaaaaaat ttggaacaga 1140 aattatccag actcgcatat aatttcacat taccaatcgg gcgtgttgta ccaggcgcat 1200 aacggatatg ataaaatcca ttgcaccaac agggactttc aactgttcac tccaagtata 1260 ggcgagacca ccgtctgcac ttcgcacact tgtggtgcta tgttgtcaca tgctaaattc 1320 aatgaactaa acgatcttga attcaaatct tgcacaatat attacgaaga gggaatgttt 1380 cagttgtatt atggtatggg tgtaaaaaaa ggcgctctca tcgacggaga cggtaggtta 1440 gtagtaatgt gtagagcgca ggagccgtat aaaaaactag atcagtattc ttttaaagct 1500 caagctatat ttaacgatgg tgccgtggaa ggttgtcatt ggaacggcat tagttgctac 1560 tcggtgccca ttgaaggtga tgttgaaata ccaccgctca cggtcagaga taatttgcta 1620 cacgaactag ttgaacaggt tttaacagct gaaaacttgt acgcatacaa aggtatagcc 1680 agttataaat taaacgttga aggtttaacg gataagctta aatgtaaaat actatcaggc 1740 ggcaacaagt ttttagtcac aatggaagaa aacaaaaaag tgctgttcgc ctttccgtgg 1800 ctgttaatta aagagcgaaa acttattacc attggtggcg taaacgaggt gaccgaaatt 1860 ccagtaaaca ccgtaaagcg cctattgcaa ctagctgaaa ttaaacgaga cccctttccg 1920 atcaattgca atctagaaga aaatagtttt gttttaaaag acacaagcga atatttacaa 1980 ttcaaatttg agatggtgcg agacgctgct aacatatata atctaatgcg taactaact 2039 <210> 3 <211> 678 <212> PRT
<213> AsGV
<400> 3 Met Val Ile Ile Leu Ile Ile Ile Ile Gly Val Leu Ile Val Ala Cys Leu Ile Tyr Tyr Tyr Leu Ser Gln Ile Asn Trp Leu Tyr Leu Phe Pro Asp Thr Phe Ser Gln Gly Arg His Val Lys Ile Phe Asn Asp Tyr Phe Ile Asn Thr Leu Asn Glu Asn Leu Asn Lys Arg Ser Tyr Lys Val Thr Lys Pro Asn Arg Ala Trp Asp Pro Asp Gln Ile Phe Asp Asp Ala Tyr Pro Trp Lys Ser Thr Ile Arg Phe Lys Tyr Val Cys Tyr Thr Leu Ile Gly Tyr Cys Ala Arg Phe Val Asn Tyr Asp Asp Glu Leu Tyr Gln Ser Pro Asp Leu Ala Tyr Asn Leu Ile Thr Ser Gln Gln Thr Ile Ala Thr His Leu Gly Thr Thr Ala Ser Val Lys Pro Pro Trp Gly Val Ala Thr Asp Trp Tyr Val Phe Arg Val Ile Leu Leu Glu Ala Phe Met Thr Ile Thr Ala Val Leu Ser Asn Thr Val Phe Tyr Leu Glu Ser Ala Arg Ile 1308 SEQ.LISTING.txt Thr Ser Phe Tyr Val Glu Leu Tyr Leu Pro Ser Leu Glu Val Gly Phe Val Arg Asn Ile Thr Asp Val Met Arg Met Gly Val Pro Tyr Met Tyr Asn Lys Leu Leu His Asn Asp Leu Ile Ser Ser Leu Glu Ile Asp Asp Leu Ser Val Lys Lys Leu Met Gln Thr Val Ser Ser Pro Val Val Val His Gly Thr Gly Leu His Lys Asp Tyr Ile Pro Val Glu Arg Met Phe Ala Arg Ser Tyr Asn Thr Ile Val Lys Ala Tyr Tyr Thr Leu Asp Tyr Tyr Gly Val Leu Phe Gln Lys Asp Val Thr Asp Met Glu Leu Ile Asn Lys Ala Leu Arg Lys Ala Ser Cys Pro Glu Gly Phe Ile His Pro Ala Leu Leu Pro Pro Leu Phe Lys Ser Phe Asn Cys Ser Asn Val Gly Lys Leu Thr Asp Tyr Pro Leu Gly Ile Arg Ser Ala Asp Tyr Ser Lys Val Leu Ser Asn Leu Thr Lys Asp Tyr Phe Gly Ser Thr Val Gly Ala Thr Pro Arg Leu Ala Tyr Tyr Glu Ser Thr Pro Leu His Asp Lys Phe Gly Pro Ala Phe Ala Met Ala Lys Lys Ile Trp Asn Arg Asn Tyr Pro Asp Ser His Ile Ile Ser His Tyr Gln Ser Gly Val Leu Tyr Gln Ala His Asn Gly Tyr Asp Lys Ile His Cys Thr Asn Arg Asp Phe Gln Leu Phe Thr Pro Ser Ile Gly Glu Thr Thr Val Cys Thr Ser His Thr Cys Gly Ala Met Leu Ser His Ala Lys Phe Asn Glu Leu Asn Asp Leu Glu Phe Lys Ser Cys Thr Ile Tyr Tyr Glu Glu Gly Met Phe Gln Leu Tyr Tyr Gly Met Gly Val Lys Lys Gly Ala Leu Ile Asp Gly Asp Gly Arg Leu Val Val Met Cys Arg Ala Gln Glu Pro Tyr Lys Lys Leu Asp Gln Tyr Ser Phe Lys Ala Gln Ala Ile Phe Asn Asp Gly Ala Val Glu Gly Cys His Trp Asn Gly Ile Ser Cys Val Pro Ile Glu Gly Asp Val Glu Ile Pro Pro Leu Thr Val Arg Asp Asn Leu Leu His Glu Leu Val Glu Gln Val Leu Thr Ala Glu Asn Leu Tyr Ala Tyr Lys Gly Ile Ala Ser Tyr 1308 SEQ.LISTING.txt Lys Leu Asn Val Glu Gly Leu Thr Asp Lys Leu Lys Cys Lys Ile Leu Ser Gly Gly Asn Lys Phe Leu Val Thr Met Glu Glu Asn Lys Lys Val Leu Phe Ala Phe Pro Trp Leu Leu Ile Lys Glu Arg Lys Leu Ile Thr Ile Gly Gly Val Asn Glu Val Thr Glu Ile Pro Val Asn Thr Val Lys Arg Leu Leu Gln Leu Ala Glu Ile Lys Arg Asp Pro Phe Pro Ile Asn Cys Asn Leu Glu Glu Asn Ser Phe Val Leu Lys Asp Thr Ser Glu Tyr Leu Gln Phe Lys Phe Glu Met Val Arg Asp Ala Ala Asn Ile Tyr Asn Leu Met Arg Asn Cys Thr <210> 4 <211> 986 <212> DNA
<213> AsGV
<400> 4 atgttttata tattgttttt gataggcctc gtccaaggtg cgctatataa tttaaatgac 60 agcgaaaagc tgtttgaaga ttttgtacaa aaatacaata aaagttatag ttcggaagag 120 gagcgtcaga taaagtttga caatttcaaa aataatatac gttctataaa cgagaaaaat 180 tccctttcga actctgctgt ctacgacatt aatttttata gtgatatgaa caagaacgaa 240 ttgctgcgca agcagacggg ttttaaaatt aacttaaaaa aaaacaattt ggatctaagt 300 tggaatatta agtgtaacaa gaaattaata aatggaaacc cggcggtgct tttaccagat 360 tcgtttgatt ggagggatcg tcacgtgatc acttcagtaa aaaaccaacg tgactgcggt 420 tcatgctggg cttttagcac catcgcaaac attgaaagtt tatacgcgat taagtataac 480 aaactattgg acctttccga gcaacaattg gtgaactgtg atgagcaaaa taatggctgc 540 aacggtggtc tgatgcattg ggctatggag gaaattatta gacaaggtgg tgtaagtaac 600 gaaacagact ttccatacac agcatcagac ggtttttgca aacgaaagca aggtttcgta 660 aacattaatg gatgtaatca atttatactc agtaatgagg atagattgag agaattgtta 720 attttcaacg gacccatttc tattgcaata gatgttatcg acgtgataga ctatagtcag 780 ggtatttcga gcacgtgtcg taatgacaac ggtttaaatc acgcagtact tttggtcggc 840 tacggtgtta agaataatat tccatattgg atacttaaaa actcttgggg atcacaatgg 900 ggagaaaatg gttattttag agttcaaaga aatatcaact cgtgcggaat gattaacgat 960 tacgcggctt cagcaatatt gtaact 986 <210> 5 <211> 327 <212> PRT
<213> AsGV

1308 SEQ.LISTING.txt <400> 5 Met Phe Tyr Ile Leu Phe Leu Ile Gly Leu Val Gln Gly Ala Leu Tyr Asn Leu Asn Asp Ser Glu Lys Leu Phe Glu Asp Phe Val Gln Lys Tyr Asn Lys Ser Tyr Ser Ser Glu Glu Glu Arg Gln Ile Lys Phe Asp Asn Phe Lys Asn Asn Ile Arg Ser Ile Asn Glu Lys Asn Ser Leu Ser Asn Ser Ala Val Tyr Asp Ile Asn Phe Tyr Ser Asp Met Asn Lys Asn Glu Leu Leu Arg Lys Gln Thr Gly Phe Lys Ile Asn Leu Lys Lys Asn Asn Leu Asp Leu Ser Trp Asn Ile Lys Cys Asn Lys Lys Leu Ile Asn Gly Asn Pro Ala Val Leu Leu Pro Asp Ser Phe Asp Trp Arg Asp Arg His Val Ile Thr Ser Val Lys Asn Gln Arg Asp Cys Gly Ser Cys Trp Ala Phe Ser Thr Ile Ala Asn Ile Glu Ser Leu Tyr Ala Ile Lys Tyr Asn Lys Leu Leu Asp Leu Ser Glu Gln Gln Leu Val Asn Cys Asp Glu Gln Asn Asn Gly Cys Asn Gly Gly Leu Met His Trp Ala Met Glu Glu Ile Ile Arg Gln Gly Gly Val Ser Asn Glu Thr Asp Phe Pro Tyr Thr Ala Ser Asp Gly Phe Cys Lys Arg Lys Gln Gly Phe Val Asn Ile Asn Gly Cys Asn Gln Phe Ile Leu Ser Asn Glu Asp Arg Leu Arg Glu Leu Leu Ile Phe Asn Gly Pro Ile Ser Ile Ala Ile Asp Val Ile Asp Val Ile Asp Tyr Ser Gln Gly Ile Ser Ser Thr Cys Arg Asn Asp Asn Gln His Ala Val Leu Leu Val Gly Tyr Gly Val Lys Asn Asn Ile Pro Tyr Trp Ile Leu Lys Asn Ser Trp Gly Ser Gln Trp Gly Glu Asn Gly Tyr Phe Arg Val Gln Arg Asn Ile Asn Ser Cys Gly Met Ile Asn Asp Tyr Ala Ala Ser Ala Ile Leu Cys Thr <210> 6 <211> 633 <212> DNA

<213> AsGV
1308 SEQ.LISTING.txt <400> 6 atggattttt tctatctaat tcatgaaact tcttttgaag cccttagcaa aatattacaa 60 agcggattct tgctgaccag ttcaaaaact caaaaattaa aagttcgtgg tcaaggttcg 120 tcaaatagaa ggttggcgag cgaccctcga gtttctttaa cagattcaga atttttcaac 180 aaatacgacg aagttgacgg tgtctatatg agacttcaac ctaaaatgca tagtatacga 240 tcgaaataca gcgactgtgt tttggtttta agaatgaatt tattaaaata ttgtaagttt 300 gtgataaact ctgaggaaaa ttttgggttt tatatagccg aagaatgtgt tattggcact 360 tctcaatttt ccggcgagcc cggttttaca acaacttctt tcgaaaaact tgctctttta 420 aaagacacta cagactattc gagcactgaa gtgttaatct tacaagatgt accagtatct 480 tttataaagt ttatattttt agttcgcgac acaaaagctg acacaatttt taaacctttg 540 gcgcgctaca acattaaatg ttttaatatc ctataattaa gagtataatg gaaatgccgg 600 aagcttatat tttgaatacc ctttacgatg act 633 <210> 7 <211> 193 <212> PRT
<213> AsGV
<400> 7 Met Asp Phe Phe Tyr Leu Ile His Glu Thr Ser Phe Glu Ala Leu Ser Lys Ile Leu Gln Ser Gly Phe Leu Leu Thr Ser Ser Lys Thr Gln Lys Leu Lys Val Arg Gly Gln Gly Ser Ser Asn Arg Arg Leu Ala Ser Asp Pro Arg Val Ser Leu Thr Asp Ser Glu Phe Phe Asn Lys Tyr Asp Glu Val Asp Gly Val Tyr Met Arg Leu Gln Pro Lys Met His Ser Ile Arg Ser Lys Tyr Ser Asp Cys Val Leu Val Leu Arg Met Asn Leu Leu Lys Tyr Cys Lys Phe Val Ile Asn Ser Glu Glu Asn Phe Gly Phe Tyr Ile Ala Glu Glu Cys Val Ile Gly Thr Ser Gln Phe Ser Gly Glu Pro Gly Phe Thr Thr Thr Ser Phe Glu Lys Leu Ala Leu Leu Lys Asp Thr Thr Asp Tyr Ser Ser Thr Glu Val Leu Ile Leu (~ln Asp Val Pro Val Ser Phe Ile Lys Phe Ile Phe Leu Val Arg Asp Thr Lys Ala Asp Thr Ile Phe Lys Pro Leu Ala Arg Tyr Asn Ile Lys Cys Phe Asn Ile Leu Cys Thr 1308 SEQ.LISTING.txt <210> 8 <211> 1418 <212> DNA
<213> AsGV
<400> 8 atggcggaga aacgagcaat tgacgagctg ttggatttag tcgagagtaa caacaaaaag 60 caaaaacagt cgtcttccag actttacgtg ccaaaaaaat tgaatgaaga acaacaaagg 120 atatacgatt atgtgacaag agttaaaaag tttgctcc:aa tctttgtgtc cggatccgct 180 ggcacaggaa aaagtgcatt gttaatcgcc ataagagatt ggtgtcgtgc agaaaagaaa 240 gttgtgtgga tagtctccta caccaatttg gccgcccgaa acatagaagg aaaaacgatt 300 cattcaatgt ttaaatttga ttttaattta aacatcagta attatcgtat taacgcaccg 360 gaattcctga taattgatga gattagtatg gtgcctgcta aaatgttaaa cggaatcgac 420 gctcaactta aaagaagcac tggagaagat gcggcatttg gaggggtgaa cacaatagtt 480 tttggagatt tataccagct accaccagtg gagaacagat ttcgacaaaa tttcacttta 540 ccaccatacc attctcatgc gtggtcagat tttcgctt:gt tcaatctcac tataaacatg 600 agacaatctg aagaattatt tattaaagcc ctaaatttgt tacgaaaggg agacgcgtct 660 tgtcaagact ttttcaactc taaagtgatc gatcaggaac cgtgtttaga ggaaaaaatc 720 aattgtacca gtctcgtcag cacacaccta gaagcgaatc atttaaataa catatgctat 780 gagtatgtaa aaagtaaaag taaagacaaa aaggaatatc aagtcaagtt aatcaaaacg 840 cttgaaaaac gacacaccac ttcaatgccg tacaataaaa gtcaagagga gatgatattt 900 aaagataata taaagtattg cgtgggaaca cgcgtgatga taactctcaa cgttcgagat 960 tttgtgggcg aaaactcttt ttgtaatggt gatataggaa ctatagtgca ggtgagcgac 1020 gaatgtttaa caatcaaaag agaatgggat ggaacagaac gaaaattaac aatgcacgga 1080 gtgttgtttg aaacagaaga taaaaacgtc ctcaaaaccg tttacggtct tcccataaca 1140 tatggttggg cggttactat acataaagct cagggtatga ctttacgtaa tttaattgtg 1200 tatccagcaa aaacgtttgt agccggtcaa gcttacgtgg ccctcagcag agctacccat 1260 tgcgacggtt taatactcgt cgatcccata ccagcaaatt ccatcaaaaa catgagagag 1320 gttgataaag tgtacgaaga acaaattaaa tttcaattta ctgaagagga gccggaagaa 1380 gaaacagttt tatataaaga aagtattttt aattaact 1418 <210> 9 <211> 471 <212> PRT
<213> AsGV
<400> 9 Met Ala Glu Lys Arg Ala Ile Asp Glu Leu Leu Asp Leu Val Glu Ser Asn Asn Lys Lys Gln Lys Gln Ser Ser Ser Arg Leu Tyr Val Pro Lys Lys Leu Asn Glu Glu Gln Gln Arg Ile Tyr Asp Tyr Val Thr Arg Val Lys Lys Phe Ala Pro Ile Phe Val Ser Gly Ser Ala Gly Thr Gly Lys Ser Ala Leu Leu Ile Ala Ile Arg Asp Trp Cys Arg Ala Glu Lys Lys 1308 SEQ.LISTING.txt Val Val Trp Ile Val Ser Tyr Thr Asn Leu Ala Ala Arg Asn Ile Glu Gly Lys Thr Ile His Ser Met Phe Lys Phe Asp Phe Asn Leu Asn Ile Ser Asn Tyr Arg Ile Asn Ala Pro Glu Phe Leu Ile Ile Asp Glu Ile Ser Met Val Pro Ala Lys Met Leu Asn Gly Ile Asp Ala Gln Leu Lys Arg Ser Thr Gly Glu Asp Ala Ala Phe Gly Gly Val Asn Thr Ile Val Phe Gly Asp Leu Tyr Gln Leu Pro Pro Val Glu Asn Arg Phe Arg Gln Asn Phe Thr Leu Pro Pro Tyr His Ser His Ala Trp Ser Asp Phe Arg Leu Phe Asn Leu Thr Ile Asn Met Arg Gln Ser Glu Glu Leu Phe Ile Lys Ala Leu Asn Leu Leu Arg Lys Gly Asp Ala Ser Cys Gln Asp Phe Phe Asn Ser Lys Val Ile Asp Gln Glu Pro Cys Leu Glu Glu Lys Ile Asn Cys Thr Ser Leu Val Ser Thr His Leu Glu Ala Asn His Leu Asn Asn Ile Cys Tyr Glu Tyr Val Lys Ser Lys Ser Lys Asp Lys Lys Glu Tyr Gln Val Lys Leu Ile Lys Thr Leu Glu Lys Arg His Thr Thr Ser Met Pro Tyr Asn Lys Ser Gln Glu Glu Met Tle Phe Lys Asp Asn Ile Lys Tyr Cys Val Gly Thr Arg Val Met Ile Thr Leu Asn Val Arg Asp Phe Val Gly Glu Asn Ser Phe Cys Asn Gly Asp Ile Gly Thr Ile Val Gln Val Ser Asp Glu Cys Leu Thr Ile Lys Arg Glu Trp Asp Gly Thr Glu Arg Lys Leu Thr Met His Gly Val Leu Phe Glu Thr Glu Asp Lys Asn Val Leu Lys Thr Val Tyr Gly Leu Pro :Ile Thr Tyr Gly Trp Ala Val Thr Ile His Lys Ala Gln Gly Met Thr Leu Arg Asn Leu Ile Val Tyr Pro Ala Lys Thr Phe Val Ala Gly Gln Ala Tyr Val Ser Arg Ala Thr His Cys Asp Gly Leu Ile Leu Val Asp Pro Ile Pro Ala Asn Ser Ile Lys Asn Met Arg Glu Val Asp Lys Val Tyr Glu Glu Gln Ile Lys Phe Gln Phe Thr Glu Glu Glu Pro Glu Glu Glu Thr Val Leu Tyr Lys 1308 SEQ.LISTING.txt Glu Ser Ile Phe Asn Cys Thr <210> 10 <211> 1196 <212> DNA
<213> AsGV
<400> 10 atggatttat caaattgtgg cttcactgat gagcagttaa aaatggctca aaaatattgc 60 atggaaaatt atgtaacaaa attaaaaccg ggtcataaaa acaccaagga agaaatcttt 120 gagttggaac gcgccactcg tggacagtgt aaaaataatc tctggaaatt attgcgcgta 180 aacagaacga ccgcaactaa aagtacaggt tcgagttttt atggggagag tgtcgctatg 240 aaatatggaa tagaacagga agaatggatc aaacaacaaa aacacattat ggacgcggtc 300 tgtgaaggaa tagaggggaa gttgaagaaa aaagtaaaag aaagagtgtt aaactgcggt 360 ttatttttaa gcccattagg aatttatagc gccagtcctg acgcgtactt tgttttagag 420 aacgaggaat tagttgtgtt agagattaaa tgtccttaca cgtacaagag tgacagtatg 480 gaaaccatta gacgaggttt caacaatcgc tcccgttacc gcattccaca caccgccttt 540 tcgataaaca aaaacggacc gattgatgtg agggtggaga aaaaaaatga ccactataga 600 cagatgcaag cccagctgta tataacggga gctgtactag ccgtttattt agtaaaaata 660 ggcgatgttc cggagataca ctttgtggag cgcgatataa aacaaataca agaattaaaa 720 gacagagaag agcgggaatt taataaccat gttcgggaca atagtcgcaa caactattta 780 gttctggagc gaaacagaaa aaaaaccttt ccacaaaacg gtgcttatag tgaagaaaaa 840 tctaaactgt tggctcgtca gggcttttat tataatcaag gatgtgttgt ttgttacttt 900 tgtaaaagca aatacgaaac atcaacacct tttctagaaa tgacacatag caactgtgat 960 aaaacagata atatcagtca cgtggacatt aaatttttca attatataaa ccaaaaagac 1020 agggttaata acttaaataa atactgttct tatgattatc aacagtgtat agagttggca 1080 aatcaaggat ttttttacga ccctagcgat aacacattaa agttattttg ctgtggcgaa 1140 attgacaagc attcgcaaaa gtgtgacaaa aatggcggag aaacgagcaa ttgact 1196 <210> 11 <211> 395 <212> PRT
<213> AsGV
<400> 11 Met Asp Leu Ser Asn Cys Gly Phe Thr Asp Glu Gln Leu Lys Met Ala Gln Lys Tyr Cys Met Glu Asn Tyr Val Thr Lys Leu Lys Pro Gly His Lys Asn Thr Lys Glu Glu Ile Phe Glu Leu Glu Arg Ala Thr Arg Gly Gln Cys Lys Asn Asn Leu Trp Lys Leu Leu Arg Val Asn Arg Thr Thr Ala Thr Lys Ser Thr Gly Ser Ser Phe Tyr Gly Glu Ser Val Ala Met Lys Tyr Gly Ile Glu Gln Glu Glu Trp Ile Lys Gln Gln Lys His Ile 1308 SEQ.LISTING.txt Met Asp Ala Val Cys Glu Gly Ile Glu Gly Lys Leu Lys Lys Lys Val Lys Glu Arg Val Leu Asn Cys Gly Leu Phe Leu Ser Pro Leu Gly Ile Tyr Ser Asp Asp Ala Tyr Fhe Val Leu Glu Asn Glu Glu Leu Val Val Leu Glu Ile Lys Cys Pro Tyr Thr Tyr Lys Ser Asp Ser Met Ile Arg Arg Gly Phe Asn Asn Arg Ser Arg Tyr Arg Ile Pro His Thr Ala Phe Ser Ile Asn Lys Asn Gly Pro Ile Asp Val Arg Val Glu Lys Lys Asn Asp His Tyr Arg Gln Met Gln Ala Gln Leu Tyr Ile Thr Gly Ala Val Leu Ala Val Tyr Leu Val Lys Ile Gly Asp Val Pro Glu Ile His Phe Val Glu Arg Asp Ile Lys Gln Ile Gln Glu Leu Lys Asp Arg Glu Glu Arg Glu Phe Asn Asn His Val Arg Asp Asn Ser Arg Asn Asn Tyr Leu Val Leu Glu Arg Asn Arg Lys Lys Thr Phe Pro Gln Asn Gly Ala Tyr Ser Glu Glu Lys Ser Lys Leu Leu Ala Arg Gln Gly Phe Tyr Tyr Asn Gln Gly Cys Val Val Cys Tyr Phe Cys Lys Ser Lys Tyr Glu Thr Ser Thr Pro Phe Leu Glu Met Thr His Ser Asn Cys Asp Lys Thr Asp Asn 305 310 :315 320 Ile Ser His Val Asp Ile Lys Phe Phe Asn Tyr Ile Asn Gln Lys Asp Arg Val Asn Asn Leu Asn Lys Tyr Cys Ser Tyr Asp Tyr Gln Gln Cys Ile Glu Leu Ala Asn Gln Gly Phe Phe Tyr Asp Pro Ser Asp Asn Thr Leu Lys Leu Phe Cys Cys Gly Glu Ile Asp Lys His Ser Gln Lys Cys Asp Lys Asn Gly Gly Glu Thr Ser Asn Cys Thr <210> 12 <211> 179 <212> DNA
<213> AsGV
<400> 12 atggataaga aaaacggtag cgatgctcct cagagcgtga aaacgatcaa gacaaacgtt 60 1308 SEQ.LISTING.txt tcttcaataa ttgaaaaaat tgtcaatcag gtctacagac ctccttcagt aaattggacg 120 gaagaaacgg aaaacggtgc cgtttggaaa aggcgtcatc aaacaaagtc ttggtgact 179 <210> 13 <211> 60 <212> PRT
<213> AsGV
<400> 13 Met Asp Lys Lys Asn Gly Ser Asp Ala Pro Gln Ser Val Lys Thr Ile Lys Thr Asn Val Ser Ser Ile Ile Glu Lys Ile Val Asn Gln Val Tyr Arg Pro Pro Ser Val Asn Trp Thr Glu Glu Thr Glu Asn Gly Ala Val Trp Lys Arg Arg His Gln Thr Lys Ser Trp Cys Thr <210> 14 <211> 1149 <212> DNA
<213> AsGV
<400> 14 tatgaataag tttaacaaat tcatttgttg gcttttaaaa atgattttgt tttataataa 60 catgtatcct attaaagtaa tacagctgcc tggacaacga ttgttcttta aattgcgcca 120 cttaataaaa gcttttggta tatcaaagac tttaattgta aaacgcgttc cacctcactg 180 tttggtaaaa tttaatttgt taaaaccttt ttgtacaaac gaaactcttt atccttccac 240 attgttcata tcgcttcgcg gtttgcaata tattaataat gatatattgc taaaatattt 300 acaaaaaagc tatcaaactc gaggcctata cattaataaa agttaccaag tcgtagaatt 360 tgacagcgat attgaggaaa gcgacgaatg tgagcgagag tatgatcttg aaaagtgtac 420 agtcggtgtt gtagagccta atatcgagtt tataaaaatg ggaaaaaggt gctatttgaa 480 agcgtgtgat gtcgcacgag ctataaactg cgcctctaca tataatatcg acaagtttgt 540 atcggacgaa aatatggtgt tatgggcgga cttgcgtgag tttttaacaa aaaaatgtga 600 aggcttcgct cccgcttact ctagatggaa acaacaaact gtctttttga aaataactgg 660 acttaaacag ctgttgttgg ctaagaatca aaaaacactg ttcgctcaaa ttaatttggc 720 gctgcaaaac tattcttcag accgcgcgcc tatatacatc aagcccacgt ctagatacta 780 taaaaagaat ttaattgccg aacagtgtgt ggtcggtaag atgtacaact atatcgattt 840 tataatgctt ccagacacaa gcgtttggtg taaattgr_gt atggttcgga aatatttttc 900 cattaaaaca ctacaagaca tgagcatgtt tcaagagtac acaacgacat ggtcggaaat 960 cgatgcgcta ttaagaagca aacgtctttc ctgtaatatt aaatggaagc aaaacacttg 1020 tttaataaac ggagaggggt tatataaact attaagaaat ttcgagctga attcacaggc 1080 tgaacgtttt tattttgaaa cactccatga acttaaaact aaattaaaaa ttaatgtcaa 1140 agtttgact 1149 <210> 15 <211> 4 <212> PRT
<213> AsGV
<400> 15 Tyr Glu Cys Thr <210> 16 <211> 449 <212> DNA
<213> AsGV
1308 SEQ.LISTING.txt <400> 16 atgcaatcgc aacacgacat cgacgactgt gtggaaattt atggattggg cgagtgggac 60 gattataaca aaactcttca attgattact aaagcgctgg atcttgacat taaagatgtt 120 ttgttttgtt caaagaaagg aaacgggttg ctggtaaaat taatagacaa tagagcggtt 180 aatgagtggg agagaaaatc aagagagaag cgtttacgat taatcgaatt gacgggttta 240 caggaggatt ctgatgtcaa agtgaagatt ttcgcagcag cgcccacaaa gtttaaacta 300 ttgctgcact cggtgcgtaa aatgttgcca aattttaagt atatatggat aggaaaaagg 360 ggggttatgg cgcgtcacga atcccgttct cagatacacc ttatcaaaaa tgaaaacgac 420 cttttgaatg ttaaagaggt ttattgact 449 <210> 17 <211> 150 <212> PRT
<213> AsGV
<400> 17 Met Gln Ser Gln His Asp Ile Asp Asp Cys Val Glu Ile Tyr Gly Leu Gly Glu Trp Asp Asp Tyr Asn Lys Thr Leu Gln Leu Ile Thr Lys Ala Leu Asp Leu Asp Ile Lys Asp Val Leu Phe Cys Ser Lys Lys Gly Asn Gly Leu Leu Val Lys Leu Ile Asp Asn Arg Ala Val Asn Glu Trp Glu Arg Lys Ser Arg Glu Lys Arg Leu Arg Leu Ile Glu Leu Thr Gly Leu Gln Glu Asp Ser Asp Val Lys Val Lys Ile Phe Ala Ala Ala Pro Thr Lys Phe Lys Leu Leu Leu His Ser Val Arg Lys Met Leu Pro Asn Phe Lys Tyr Ile Trp Ile Gly Lys Arg Gly Val Met Ala Arg His Glu Ser Arg Ser Gln Ile His Leu Ile Lys Asn Glu Asn Asp Leu Leu Asn Val Lys Glu Val Tyr Cys Thr <210> 18 <211> 1337 <212> DNA
<213> AsGV
1308 SEQ.LISTING.txt <400> 18 atgtacggag ttgagaggtg gaaatatatt tgtttgaagg agggttctag accgcgatca 60 ttgtttgatt tggccgcgtt agcgttaccg cccggcattc gcattgaaaa aatctttaac 120 gaaccattga ttcgattaat taaaggagtg catggatttt tcttgtgtgt acgatgtgaa 180 cttacgctgc agtatagcga aaatcgtata aactattgct ggcaatgtgc ggataaatgt 240 ttgttttgcg aacgaacagg acgtgttcgc gtctgggacg atgacgctga agcgagaata 300 tttaaataca acaacagact gcaggtatac gaagtgttat acgacagcga gcctaacaca 360 ataaatttgg aggattacga aaattgtgaa gagaagcatg aaaatcatta cgtttttgac 420 aaaatggtaa agctaatttg cgatcattgc tttgtcaatt atgactactg caccgcttgc 480 cgggattatt tacacttcac taagctgata ccaatcagaa tttatttcgt ttacgacagg 540 caagatccta tacctccgac ggattttaaa agtttatgtg aaacgtgtgc attgaagcta 600 caatgttata tttgcggacc tgaaaagcgc tttactagcg aagatataaa gcgttttcgc 660 gacacgacca tacagttcat gtttgcttcg cttcggtcaa gaacggtgtg ctttgatcat 720 gcccattgcg tgatatttag tcacccctac agacaggaca gtgattattc gtccgacgag 780 gacaaccaaa cgttttattt gcatcatacc atgagaccaa tacaatattt accggaacct 840 cccataacac tacacgaagc ttctttattg agaaatccca agtcgatgct taatgcggta 900 aaaaccctgg caaaacgcga agaggagaat ataattgacg cgcaagaggc agcaaaattg 960 ctgtgcaatc tgccggacat agagcgtatc gacttgatcc gattattgat ttatgttttg 1020 gaaaataaaa aaaacgcagt ggtgttgaat gtgtacgaga gcactggtgt gcagtggata 1080 aattgccgca aatgctcacc cccggacgga atttggaaga atatgtatta tgtacaaaaa 1140 gactgctgca acgccattaa gtatatgagt tacaattt:tg atgaggatct cacaccaatt 1200 cttttagagg agacgagcta ttgcgcagaa tgctcttc:cc ccttgtttat gttgattgat 1260 gctgagcacg atagcgacta tcagtgcgat tgtgatgata tgtgttaatt tggtatcttt 1320 atgaataagt ttaacct 1337 <210> 19 <211> 435 <212> PRT
<213> AsGV
<400> 19 Met Tyr Gly Val Glu Arg Trp Lys Tyr Ile Cys Leu Lys Glu Gly Ser Arg Pro Arg Ser Leu Phe Asp Leu Ala Ala Leu Pro Pro Gly Ile Arg Ile Glu Lys Ile Phe Asn Glu Pro Leu Ile Arg Leu Ile Lys Gly Val His Gly Phe Phe Leu Cys Val Arg Cys Glu Leu Thr Leu Gln Tyr Ser Glu Asn Arg Ile Asn Tyr Cys Trp Gln Cys Ala Asp Lys Cys Leu Phe 1308 SEQ.LISTING.txt 65 70 '75 80 Cys Glu Arg Thr Gly Arg Val Arg Val Trp Asp Asp Asp Ala Glu Ala Arg Ile Phe Lys Tyr Asn Asn Arg Leu Gln Val Tyr Glu Val Leu Tyr Asp Ser Glu Pro Asn Thr Ile Asn Leu Glu Asp Tyr Glu Asn Cys Glu Glu Lys His Glu Asn His Tyr Val Phe Asp Lys Met Val Lys Leu Ile Cys Asp His Cys Phe Val Asn Tyr Asp Tyr Cys Thr Ala Cys Arg Asp Tyr Leu His Phe Thr Lys Leu Ile Pro Ile Arg Ile Tyr Phe Val Tyr Asp Arg Gln Asp Pro Ile Pro Pro Thr Asp Phe Lys Ser Leu Cys Glu Thr Cys Ala Leu Lys Leu Gln Cys Tyr Ile Cys Gly Pro Glu Lys Arg Phe Thr Ser Glu Asp Ile Lys Arg Phe Arg Asp Thr Thr Ile Gln Phe Met Phe Ala Ser Leu Arg Ser Arg Thr Val Cys Phe Asp His Ala His Cys Val Ile Phe Ser His Pro Tyr Arg Gln Asp Ser Asp Tyr Ser Ser Asp Glu Asp Asn Gln Thr Phe Tyr Leu His His Thr Met Arg Pro Ile Gln Tyr Leu Pro Glu Pro Pro Ile Thr Leu His Glu Ala Ser Leu Leu Arg Asn Pro Lys Ser Met Leu Asn Ala Val Lys Thr Leu Ala Lys Arg Glu Glu Glu Asn Ile Ile Asp Ala Gln Glu Ala Ala Lys Leu Leu Cys 305 310 :315 320 Asn Leu Pro Asp Ile Glu Arg Ile Asp Leu Ile Arg Leu Leu Ile Tyr Val Leu Glu Asn Lys Lys Asn Ala Val Val Leu Asn Val Tyr Glu Ser Thr Gly Val Gln Trp Ile Asn Cys Arg Lys Cys Ser Pro Pro Asp Gly Ile Trp Lys Asn Met Tyr Tyr Val Gln Lys Asp Cys Cys Asn Ala Ile Lys Tyr Met Ser Tyr Asn Phe Asp Glu Asp Leu Thr Pro Ile Leu Leu Glu Glu Thr Ser Tyr Cys Ala Glu Cys Ser Ser Pro Leu Phe Met Leu Ile Asp Ala Glu His Asp Ser Asp Tyr Gln Cys Asp Cys Asp Asp Met Cys Cys Thr Ile Glu Lys Ile Phe Asn Glu Pro Leu Ile A

1308 SEQ.LISTING.txt <210> 20 <211> 842 <212> DNA
<213> AsGV
<400> 20 atgccggaag cttatatttt gaataccctt tacgatgatt tgtataaatt tatatggccc 60 gtactcatag agagaggtga aaataattta tggttagatc tggttgcgtt gaaaccatac 120 tttaaagata tttgtttaaa acacaatggg aagaataaag tagaatttgt tatacttaac 180 gatgaccaaa atgttttttc ttctgattat ttttttgt:tc cagtcaaaag tataaacaca 240 tgttttagcg acgacgagat aattaataca acttttaaga ccgtactgag ccagtttctt 300 tggtgccaac ttccaccaat cattcataaa cgtctagatg atcttaaact cgtttccatt 360 tttgatatag cggatttttg gaacaaatta aaacttttag atcactttca aaaatattgg 420 ttgtttcggt ataaaattgt tgtaatgcgt tacgagaatg agaagtgttt aagagaacag 480 aataatgatt ccgaaacttc tgttgaagat ggtgtcgacg acggaccaaa aaatgatttt 540 aaaacttccc cagagatggt ctgcgacatc aactgtgaga cagaattgaa aagtaaagaa 600 gaaaaaataa aagagttaga tttagattct tcatatatta atacaataaa taaagaaaac 660 gtttctctta tcgatagctt aatgtctaat attgacaaac agtttgaagg aatcaagaaa 720 aatgatacag agtacacaaa attacacaca agaaatgctt tcttaacatt attaattgga 780 actactgcgt tattggaaca gtttttacac tggtgttaaa tattgtttca tagtttttag 840 ct 842 <210> 21 <211> 272 <212> PRT
<213> AsGV
<400> 21 Met Pro Glu Ala Tyr Ile Leu Asn Thr Leu Tyr Asp Asp Leu Tyr Lys Phe Ile Trp Pro Val Leu Ile Glu Arg Gly Glu Asn Asn Leu Trp Leu Asp Leu Val Lys Pro Tyr Phe Lys Asp Ile Cys Leu Lys His Asn Gly Lys Asn Lys Val Glu Phe Val Ile Leu Asn Asp Asp Gln Asn Val Phe Ser Ser Asp Tyr Phe Phe Val Pro Val Lys Ser Ile Asn Thr Cys Phe 65 70 '75 80 Ser Asp Asp Glu Ile Ile Asn Thr Thr Phe Lys Thr Val Leu Ser Gln Phe Leu Trp Cys Gln Leu Pro Pro Ile Ile His Lys Arg Leu Asp Asp Leu Lys Leu Val Ser Ile Phe Asp Ile Ala Asp Phe Trp Asn Lys Leu Lys Leu Leu Asp His Phe Gln Lys Tyr Trp Leu Phe Arg Tyr Lys Ile Val Val Met Arg Tyr Glu Asn Glu Lys Cys Leu Arg Glu Gln Asn Asn 1308 SEQ.LISTING.txt Asp Ser Glu Thr Ser Val Glu Asp Gly Val Asp Asp Gly Pro Lys Asn Asp Phe Lys Thr Ser Pro Glu Met Val Cys Asp Ile Asn Cys Glu Thr Glu Leu Lys Ser Lys Glu Glu Lys Ile Lys Glu Leu Asp Leu Asp Ser Ser Tyr Ile Asn Thr Ile Asn Lys Glu Asn Val Ser Leu Ile Asp Ser Leu Met Ser Asn Ile Asp Lys Gln Phe Glu Gly Ile Lys Lys Asn Asp Thr Glu Tyr Thr Lys Leu His Thr Arg Asn Ala Phe Leu Thr Leu Leu Ile Gly Thr Thr Ala Leu Leu Glu Gln Phe Leu His Trp Cys Cys Thr <210> 22 <211> 1493 <212> DNA
<213> AsGV
<400> 22 atggaggaaa gagttaagtt tgcaaaacga gacagaacct caataactat tttgcgcgat 60 ataaatgctc tccaaaattg tataatgatg acaagtgaga aattcggaaa atttgtaaga 120 gatcttttga gcgatctaaa acacaacaag tgtgcctatt ataattctgt tgtcggacag 180 ctgatcactt cacatcaaga ttgtaatgaa acatcttcat atacaaacgt tttagcaaaa 240 gtgcttttag ctaataatgt cataattaca gacattgaag agagcgtatt tcttcggaag 300 ctctatatta ataaatacac agatgatatt gattatctca tcttaccaaa cttcacactg 360 tgggaccata actttttagt gtttatgaat aaaaaatt:ta atagcaaaaa gtctggaggc 420 ttggtaaaca tttggggttg tatgcagaaa attcccctta cacagggtgt tataaaagat 480 cttatacaaa acaaaaacgg gtacgctggc caatattt:gt actcgacgtt tttaaacact 540 tccagctttt atgctaatgt tcagtgtttt aacgggatca atgaggttat accaccctta 600 ccgagtatac tacgctatta tggtcgacga gtgccatctg tgaaagtgtg gaacactcgc 660 catcctaaca tctcgcaact ctccacacaa ttttcgagag taattgaaga gaaaaacgga 720 gtgaattgga acattaaagt tggtctcgga acgtttgtag gagccaatag agattgcgac 780 ggagataaag aagttatcac gtatttacct tatccaaact ctttaattga actggaatcg 840 ttgttgtatt gcgatcctaa atacagtttc ttatgctttg acaaaaacaa attatcgttt 900 gtctcacaac agatatacta tttatacaaa aacattaatg ttgtagagaa agaaatagcc 960 aaatttcctt tggcttggca catttggaat catcacaaaa ctttaaaatt ttccaagagg 1020 ttcgattctt tttttaccga tgtcactctc ttgttgagct ccaatttttc taccttactt 1080 ttcaaacgat tatgtagcat aattgaacaa gaagaaat:ga tttgtgaaag taaagattta 1140 gaaaatctag acgggtgttt tgatgatatt gtcaacagcg gagctaaggg tagttataat 1200 ttaatatcaa gcactaaaca gtacaaaaat acacagaaag aagatattaa acaagtggcg 1260 gaaagagcca taaacgggct caattcacat attactagtc acggacgagt aaagtttagc 1320 gggggagata tatatcacaa cacagttgtg tttctgaatc tatatttgaa aaacaataag 1380 atatgttaca agcaagacgg tttgtgtatt ggtgacgtga gtcatattcc gtccgatttc 1440 ctttttccaa cacacttatt agatatgttt attagagata aggagttttg act 1493 1308 SEQ.LISTING.txt <210> 23 <211> 494 <212> PRT
<213> AsGV
<400> 23 Met Glu Glu Arg Val Lys Phe Ala Lys Arg Asp Arg Thr Ser Ile Thr Ile Leu Arg Asp Ile Asn Ala Leu Gln Asn Cys Ile Met Met Thr Ser Glu Lys Phe Gly Lys Phe Val Arg Asp Leu Leu Ser Asp Leu Lys His Asn Lys Cys Ala Tyr Tyr Asn Ser Val Val Gly Gln Leu Ile Thr Ser His Gln Asp Cys Asn Glu Thr Ser Ser Tyr Thr Asn Val Leu Ala Lys Val Leu Leu Ala Asn Asn Val Ile Ile Thr Asp Ile Glu Glu Ser Val Phe Leu Arg Lys Leu Tyr Ile Asn Lys Tyr Thr Asp Asp Ile Asp Tyr Leu Ile Leu Pro Asn Phe Thr Leu Trp Asp His Asn Phe Leu Val Phe Met Asn Lys Lys Phe Asn Ser Lys Lys Ser Gly Gly Leu Val Asn Ile Trp Gly Cys Met Gln Lys Ile Pro Leu Thr Gln Gly Val Ile Lys Asp Leu Ile Gln Asn Lys Asn Gly Tyr Ala Gly Gln Tyr Lys Thr Phe Leu Asn Thr Ser Ser Phe Tyr Ala Asn Val Gln Cys Phe Asn Gly Ile Asn Glu Val Ile Pro Pro Leu Pro Ser Ile Leu Arg Tyr Tyr Gly Arg Arg Val Pro Ser Val Lys Val Trp Asn Thr Arg His Pro Asn Ile Ser Gln Leu Ser Thr Gln Phe Ser Arg Val Ile Glu Glu Lys Asn Gly Val Asn Trp Asn Ile Lys Val Gly Leu Gly Thr Phe Val Gly Ala Asn Arg Asp Cys Asp Gly Asp Lys Glu Val Ile Thr Tyr Leu Pro Tyr Pro Asn Ser Leu Ile Glu Leu Glu Ser Leu Leu Tyr Cys Asp Pro Lys Tyr Ser Phe Leu Cys Phe Asp Lys Asn Lys Leu Ser Phe Val Ser Gln Gln Ile Tyr Tyr Leu Tyr Lys Asn Ile Asn Val Val Glu hys Glu Ile Ala Lys Phe 305 310 .315 320 Pro Leu Ala Trp His Ile Trp Asn His His Lys Thr Leu Lys Phe Ser 1308 SEQ.LISTING.txt Lys Arg Phe Asp Ser Phe Phe Thr Asp Val Thr Leu Leu Leu Ser Ser Asn Phe Ser Thr Leu Leu Phe Lys Arg Leu Cys Ser Ile Ile Glu Gln Glu Glu Met Ile Cys Glu Ser Lys Asp Leu Glu Asn Leu Asp Gly Cys Phe Asp Asp Ile Val Asn Ser Gly Ala Lys Gly Ser Tyr Asn Leu Ile Ser Ser Thr Lys Gln Tyr Lys Asn Thr Gln Lys Glu Asp Ile Lys Gln Val Ala Glu Arg Ala Ile Asn Gln Ser His Ile Thr Ser His Gly Arg Val Lys Phe Ser Gly Gly Asp Ile Tyr His Asn Thr Val Val Phe Leu Asn Leu Tyr Leu Lys Asn Asn Lys Ile Cys Tyr Lys Gln Asp Gly Leu Cys Ile Gly Asp Val Ser His Ile Pro Ser Asp Phe Leu Phe Pro Thr His Leu Leu Asp Met Phe Ile Arg Asp Lys Glu Phe Cys Thr <210> 24 <211> 1414 <212> DNA
<213> AsGV
<400> 24 atggatgaag tagagaagga gtttgaaatt agttatactt ttacttttcc tcaagatatg 60 ctgtatctga ttaaaaactt cttagataaa cacttttcaa ttaaagagga atatgtagag 120 gttttggaca aaaataatgt gcgctctcgt atatttatag atgggacgat aaaaagtgtt 180 aaaaagagtg tcgtcgaaag tggtagatgt gttgttccac tggtggacgg ttttgtacca 240 atgatagagc gtgagtgcga cgaaaaaata tatcacgaaa gagacgaaaa aattaaacgt 300 atttgcaaga ctagggttta tcagcgaacg aacgaattag ataacgccga aataaaattt 360 gaacacatat attatgagta cagcgaaggt gactttti~ag atccgctaac ggctaacaaa 420 caaattgctt tgtataatct tctgaaaccc accgaggaga taaatacgac caacaactct 480 catttgggta gtgatgaaat tttatgtaat tgtagagtag agtttgagta tgataaaaga 540 cctgaacaaa ataagttaat tcggctagcc gagctcattc aatacatcga atacaatctt 600 ctggtcgaca ctgaaataca accgtttttg tctcacacga atatatttaa tgaaattatg 660 tatagatctt ttacggaaga gaggcttatt acagataact gtagcgatgt ggtgttatgg 720 gctttaaaat tggacgggac gcgaggtaaa ggttacgtgg taaacgataa cactctgttt 780 attcagttgg atgatatgca aatgttttcc aatgtgttgg agccgattct taaaaatgat 840 tccgataccg gctcaaaaaa gtgttttgaa aagatttttg ggtcgtatgc aacatcacca 900 gtaagattta gctccaatag attgttgggt gttcaagtgg aatatgtttg ttcgacaaaa 960 acattttacg taacagacgt cctgaacgtt tacaaataca catacgataa taaaaatcaa 1020 tttgatgttt cggcacctta tcacgtgaac atttatgatg caatgaactt tatgacaaca 1080 tcttgtcgta aagagtttaa atacggagac tatattgi~aa aatttcaacg cttttatccg 1140 1308 SEQ.LISTING.txt tgtcgtaaag atgtagaaga aattgatttg aacgacggtt atataggtct tttacaagaa 1200 ggagatattg ttaaaattaa gcactgcaaa tcttttgaaa tgaaatatat gggtaaaagt 1260 gaatttataa gtactactgg tgtgtttaag actgacaatt gtattggttt ggaaattgga 1320 agtatatacg aagtaaaaat gtcgcagcca gacgaaaata aggtgtgtgt aataaaaaaa 1380 agacccgatc gcttgctatt caactgatat aact 1414 <210> 25 <211> 470 <212> PRT
<213> AsGV
<400> 25 Met Asp Glu Val Glu Lys Glu Phe Glu Ile Ser Tyr Thr Phe Thr Phe Pro Gln Asp Met Leu Tyr Leu Ile Lys Asn Phe Leu Asp Lys His Phe Ser Ile Lys Glu Glu Tyr Val Glu Val Leu Asp Lys Asn Asn Val Arg Ser Arg Ile Phe Ile Asp Gly Thr Ile Lys Ser Val Lys Lys Ser Val Val Glu Ser Gly Arg Cys Val Val Pro Leu Val Asp Gly Phe Val Pro Met Ile Glu Arg Glu Cys Asp Glu Lys Ile Tyr His Glu Arg Asp Glu Lys Ile Lys Arg Ile Cys Lys Thr Arg Val Tyr Gln Arg Thr Asn Glu Leu Asp Asn Ala Glu Ile Lys Phe Glu His Ile Tyr Tyr Glu Tyr Ser Glu Gly Asp Phe Leu Asp Pro Leu Thr Ala Asn Lys Gln Ile Ala Leu Tyr Asn Leu Leu Lys Pro Thr Glu Glu Ile Asn Thr Thr Asn Asn Ser His Leu Gly Ser Asp Glu Ile Leu Cys Asn Cys Arg Val Glu Phe Glu Tyr Asp Lys Arg Pro Glu Gln Asn Lys Leu Ile Arg Leu Ala Glu Leu Ile Gln Tyr Ile Glu Tyr Asn Leu Leu Val Asp Thr Glu Ile Gln Pro Phe Leu Ser His Thr Asn Ile Phe Asn Glu Ile Met Tyr Arg Ser Phe Thr Glu Glu Arg Leu Ile Thr Asp Asn Cys Ser Asp Val Val Leu Trp Ala Leu Lys Leu Asp Gly Thr Arg Gly Lys Gly Tyr Val Val Asn Asp Asn Thr Leu Phe Ile Gln Leu Asp Asp Met Gln Met Phe Ser Asn Val Leu Glu Pro Ile Leu Lys Asn Asp Ser Asp Thr Gly Ser Lys Lys Cys 1308 SEQ.LISTING.txt Phe Glu Lys Ile Phe Gly Ser Tyr Ala Thr Ser Pro Val Arg Phe Ser Ser Asn Arg Leu Leu Gly Val Gln Val Glu Tyr Val Cys Ser Thr Lys Thr Phe Tyr Val Thr Asp Val Leu Asn Val Tyr Lys Tyr Thr Tyr Asp Asn Lys Asn Gln Phe Asp Val Ser Ala Pro Tyr His Val Asn Ile Tyr Asp Ala Met Asn Phe Met Thr Thr Ser Cys Arg Lys Glu Phe Lys Tyr Gly Asp Tyr Ile Val Lys Phe Gln Arg Phe Tyr Pro Cys Arg Lys Asp Val Glu Glu Ile Asp Leu Asn Asp Gly Tyr Ile Gly Leu Leu Gln Glu Gly Asp Ile Val Lys Ile Lys His Cys Lys Ser Phe Glu Met Lys Tyr Met Gly Lys Ser Glu Phe Ile Ser Thr Thr Gly Val Phe Lys Thr Asp Asn Cys Ile Gly Leu Glu Ile Gly Ser Ile Tyr Glu Val Lys Met Ser Gln Pro Asp Glu Asn Lys Val Cys Val Ile Lys Lys Arg Pro Asp Arg Leu Leu Phe Asn Cys Thr <210> 26 <211> 854 <212> DNA
<213> AsGV
<400> 26 atgaactctt acgaaacacg tcttaaaact tttgatcaat ggcagggaag agaggataag 60 gcccgtttag cgagcttggg attttattac acgggtcaga gcgatagggt aatttgtgct 120 ttttgtaaac tcgacctgta caactttagt aaaaacacca acgccctcta cgatcataaa 180 agatattcac ctcactgtcc cttcattttt ggccaatgca acccgggtaa ttatttcaat 240 acctcgttta tatcaccacg tgtcgtttca tctaactatc ctaacttagc tattgacacg 300 gcacaccact catataattt gttggagcat cggtcgctta gctttaaaaa ttaccctaaa 360 tgtcttaagc acttggtcta tcgtatgtgt ttagcgggtc tttattacac aaacgtgggc 420 gactgcgttt cctgttacgc gtgcggagtt ataataaaag attgggcacc agatgacgac 480 ccctcgaaaa gacaccaagc ctcaaactct ctatgtagta ttaatagatg tgctgataca 540 ttgtgtgtta acagtaccca agagaagaac gttgaagaga atcaacaaag taatttcaaa 600 gctagcgctc ccgctttgga ggatttgcat tatacaccaa accattacaa gattccattt 660 tgtttactgt gtaaatgtaa cgaaatcgat tgcgtattat taccatgcta ccatttttgc 720 gcttgcagcg aatgctcacc gacgtgtctt gaatgtcctg cgtgtcacgt gacgtgtact 780 ggtttttttt tagttaaaat accaaaaccc caactcgatt ccgtttgtgt tagcaatgga 840 ggaaagagtt aact 854 1308 SEQ.LISTING.txt <210> 27 <211> 281 <212> PRT
<213> AsGV
<400> 27 Met Asn Ser Tyr Glu Thr Arg Leu Lys Thr Phe Asp Gln Trp Gln Gly Arg Glu Asp Lys Ala Arg Leu Ala Ser Leu Gly Phe Tyr Tyr Thr Gly Gln Ser Asp Arg Val Ile Cys Ala Phe Cys Lys Leu Asp Leu Tyr Asn Phe Ser Lys Asn Thr Asn Ala Leu Tyr Asp His Lys Arg Tyr Ser Pro His Cys Pro Phe Ile Phe Gly Gln Cys Asn Pro Gly Asn Tyr Phe Asn 65 70 '75 80 Thr Ser Phe Ile Ser Pro Arg Val Val Ser :3er Asn Tyr Pro Asn Leu Ala Ile Asp Thr Ala His His Ser Tyr Asn Leu Leu Glu His Arg Ser Leu Ser Phe Lys Asn Tyr Pro Lys Cys Leu Lys His Leu Val Tyr Arg Met Cys Leu Ala Gly Tyr Thr Asn Val Gly Asp Cys Val Ser Cys Tyr Ala Cys Gly Val Ile Ile Lys Asp Trp Ala Pro Asp Asp Asp Pro Ser Lys Arg His Gln Asn Ser Leu Cys Ser Ile Asn Arg Cys Ala Asp Thr Leu Cys Val Asn Ser Thr Gln Glu Lys Asn Val Glu Glu Asn Gln Gln Ser Asn Phe Lys Ala Ser Ala Pro Ala Leu Glu Asp Leu His Tyr Thr Pro Asn His Tyr Lys Ile Pro Phe Cys Leu Leu Cys Lys Cys Asn Glu Ile Asp Cys Val Leu Leu Pro Cys Tyr His Phe Cys Ala Cys Ser Glu Cys Ser Pro Thr Cys Leu Glu Cys Pro Ala Cys His Val Thr Cys Thr Gly Phe Phe Leu Val Lys Ile Pro Lys Pro Gln Leu Asp Ser Val Cys Val Ser Asn Gly Gly Lys Ser Cys Thr <210> 28 <211> 262 <212> DNA
<213> AsGV

1308 SEQ.LISTING.txt <400> 28 atgccatata ataatgtctc tgaccttcca tccagggtaa agaattcgct accttatcag 60 gcgcaaagaa tgtacttgcg cgtatataac tctgccatgg atcgttacga gaatccgagt 120 cgtgtagcgt ggggtgtggt aaaaaaacac tacacaaaac taaaagatgg tagatgggtt 180 caaagagacg aagcgctcac cgacacatca gacaccacca ctaccgacga cgatgaattt 240 tactaattga taatgcctag ct 262 <210> 29 <211> 83 <212> PRT
<213> AsGV
<400> 29 Met Pro Tyr Asn Asn Val Ser Asp Leu Pro Ser Arg Val Lys Asn Ser Leu Pro Tyr Gln Ala Gln Arg Met Tyr Leu Arg Val Tyr Asn Ser Ala Met Asp Arg Tyr Glu Asn Pro Ser Arg Val Ala Trp Gly Val Val Lys Lys His Tyr Thr Lys Leu Lys Asp Gly Arg Trp Val Gln Arg Asp Glu Ala Leu Thr Asp Thr Ser Asp Thr Thr Thr Thr Asp Asp Asp Glu Phe Tyr Cys Thr <210> 30 <211> 1983 <212> DNA
<213> AsGV
<400> 30 atggtttctg cagacactac tattgacaga cccgattttg ctcctgtagc tgttaaagtt 60 aaagttatgg accccgttgc ggattcccta aagcataacg ctcctatagt tacatcttca 120 attactatat taccagtaat taacttaccc aatgggcctg tgactagttt aacttgtaat 180 aagccaatac aagctgtcgg ccagtttaat gctcaacacg aattcgtagc atcatgtaat 240 tataaagagc caatagtgtt agacgaagca gatcacctag gccttgtctc tcctaaactg 300 ttctttcctt tacagtataa aagttcgaaa tccgacttac ctccttatga ggaattttgt 360 aaatatttgc gtaacgacgt actattgtat agacgagatg ctgtacataa atctctcata 420 gagatcgatg gtacttggat tcctaatgtt tttattgact gtgagaatag gaaactgtcg 480 tttaaaggtc ccaatggaat tctatgtcaa cgttatattt tttgcaaacc aacggctgaa 540 tgtaaaatat tgccagtggc tctgttttct aatattaaac gttctttata ttgtgtcacc 600 tataatctaa agcttaaaag agaaattatg actgactttg atccaaagta tatgtctttt 660 attgtattta ataaaaaaac tggtcggttt tacagaaatt gttttgcatc tattatttca 720 aggtccaagc ttagtgttag attttatgtt atggatttgt tgaaagcgca gaacttagtt 780 tgtatattaa ttaagaaacg tttctttact gcggagtatg taaattagtt aattagtacg 840 1308 SEQ.LISTING.txt attatgtaac aataaactta tattcttttg ttaaacttgt cttttttttc tttatagtca 900 aaaccctctt cttcctactc ttcatcatcg gacgatgtgg agagtctgag tccggccctg 960 atgcggcgtt accaaaagga ggtggagcgt caggcgaaac gtgaggctaa aaagttggct 1020 caaaaggcaa agttggataa aaagttaaag gttaaacttc aaaaggtggt gaacaccact 1080 gagactatta ctgtaacatc tacagatgtt ttagagttac actctgtggt gactcaatca 1140 acattgaata gtatggatcc catggtggcc gcttttccaa acaacacaga acctttgaat 1200 attaaccaat tgaggttggt tgttcttaaa tgttataata tattgttaga tagtattttg 1260 attaatgtta acgatgagtt ggcttctcaa gcacaagaaa tggttagcgg tctaaagtcg 1320 gctttgcata aatatttgaa taacgaaaga gatttgacac aggcggcttt taatgttttg 1380 cagagttgtt taactagatc ttttgatgaa ttttacgaca tcaaggccat tcttcctata 1440 acgataacaa catcaaacac tttgaattca atttgtaata atctttctaa cacagataat 1500 ttagatgtta tagaaccatt ggttacagct acttatagct tgtgtcaaaa ttgtaaggtg 1560 tttcagaccg ctcaaaactt gcggtttaaa tcttatcgtt atttgggttt aactacggag 1620 cagtgtatag aagcagactc tttggttaat gatgaaccag cgtttttgaa ttatattgag 1680 tcaaatagaa agtggaggta caacaacgcc ggttatatgt ttaacgattc aacttgcgta 1740 ttctaaacgc tgacgatttg taaaatagat tttttgtata ttattattgt tattatttgt 1800 tatatatagt tatagtggtt atggtgttaa taaatatagt ggttatggtg ttaataaata 1860 ttgaacatta aacaagaaaa ctttttatta tcaattcctt ttaaccattg catgtttcac 1920 acgacgggca aagataaggg ttcatttagt atagcaagaa tatcgttttc tttcttacta 1980 act 1983 <210> 31 <211> 275 <212> PRT
<213> AsGV
<400> 31 Met Val Ser Ala Asp Thr Thr Ile Asp Arg Pro Asp Phe Ala Pro Val Ala Val Lys Val Lys Val Met Asp Pro Val Ala Asp Ser Leu Lys His Asn Ala Pro Ile Val Thr Ser Ser Ile Thr Ile Leu Pro Val Ile Asn Leu Pro Asn Gly Pro Val Thr Ser Leu Thr Cys Asn Lys Pro Ile Gln Ala Val Gly Gln Phe Asn Ala Gln His Glu Phe Val Ala Ser Cys Asn Tyr Lys Glu Pro Ile Val Leu Asp Glu Ala Asp His Leu Gly Leu Val Ser Pro Lys Leu Phe Phe Pro Leu Gln Tyr Lys Ser Ser Lys Ser Asp Leu Pro Pro Tyr Glu Glu Phe Cys Lys Tyr Leu Arg Asn Asp Val Leu Leu Tyr Arg Arg Asp Ala Val His Lys Ser Leu Ile Glu Ile Asp Gly Thr Trp Ile Pro Asn Val Phe Ile Asp Cys Glu Asn Arg Lys Leu Ser Phe Lys Gly Pro Asn Gly Ile Leu Cys Gln Arg Tyr Ile Phe Cys Lys 1308 SEQ.LISTING.txt Pro Thr Ala Glu Cys Lys Ile Leu Pro Val Phe Ser Asn Ile Lys Arg Ser Leu Tyr Cys Val Thr Tyr Asn Leu Lys Leu Lys Arg Glu Ile Met Thr Asp Phe Asp Pro Lys Tyr Met Ser Phe Ile Val Phe Asn Lys Lys Thr Gly Arg Phe Tyr Arg Asn Cys Phe Ala Ser Ile Ile Ser Arg Ser Lys Leu Ser Val Arg Phe Tyr Val Met Asp Leu Leu Lys Ala Gln Asn Leu Val Cys Ile Leu Ile Lys Lys Arg Phe Phe Thr Ala Glu Tyr Val Asn Cys Thr <210> 32 <211> 392 <212> DNA
<213> AsGV
<400> 32 atggcagttt ccgagggtct cttcgacatt cttcaaaagt acaattggca aattgtcaat 60 aacaacttta ttgaggttat cagtaacgat cgagaagatg cttggaaaga tattattatt 120 ctatctttga aaactacacc gaaaaactat cgcagtaata ttcggaaagg aatgctcgaa 180 cactttgatt acaaacaacc gatatattat gatctcaaga agcggcaatt aaacttgact 240 aatgatagta ttatcaaagc actaacacct cctcaacata cagcagccga taccggattg 300 gttaagcccg ttaatgtcgt aaccgtattt atattagctg tgttatcgta catcacatgg 360 aagggggtga ggtctgagga atttatatga ct 392 <210> 33 <211> 131 <212> PRT
<213> AsGV
<400> 33 Met Ala Val Ser Glu Gly Leu Phe Asp Ile Leu Gln Lys Tyr Asn Trp Gln Ile Val Asn Asn Asn Phe Ile Glu Val Ile Ser Asn Asp Arg Glu Asp Ala Trp Lys Asp Ile Ile Ile Leu Ser Leu Lys Thr Thr Pro Lys Asn Tyr Arg Ser Asn Ile Arg Lys Gly Met Leu Glu His Phe Asp Tyr Lys Gln Pro Ile Tyr Tyr Asp Leu Lys Lys Arg Gln Leu Asn Leu Thr Asn Asp Ser Ile Ile Lys Ala Leu Thr Pro Pro Gln His Thr Ala Ala 1308 SEQ.LISTING.txt Asp Thr Gly Leu Val Lys Pro Val Asn Val Val Thr Val Phe Ile Leu Ala Val Leu Ser Tyr Ile Thr Trp Lys Gly Val Arg Ser Glu Glu Phe Ile Cys Thr <210> 34 <211> 530 <212> DNA
<213> AsGV
<400> 34 atggcaaccc tgaatttgta tacgtttaaa cccaacgtct tatgtctcga cgagagtgat 60 gaacgagaag aaatgtatat tcaaggtata gtggaggctg tagaaaatca aagctgcgac 120 aaattggcgt gctttctaga attaaaaaaa gagcaggtct tgctactcaa gagattatca 180 gaccatattt taaacagaac atcgggcaac tattttagaa accatgtcct tctggacgtt 240 ctagttatgt ataaaaagta taatgaagaa ttcggtgagg atacggcttt tgggaacgaa 300 tgtgcgcaac tttgtttgga gattgttcaa ctaatgtacg agctgtttag ttgcactacc 360 aatattgttg tgctgattga aagcgaagct gacccggagg atgaaataaa tcttctttta 420 gcgcatttag aaagaagtaa gtatattgcg acagaaaagg tgtgtaaatt tggaaaaaca 480 ccaagactac aatttagtat ataaaaactt cataaattat aaggaatact 530 <210> 35 <211> 169 <212> PRT
<213> AsGV
<400> 35 Met Ala Thr Leu Asn Leu Tyr Thr Phe Lys Pro Asn Val Leu Cys Leu Asp Glu Ser Asp Glu Arg Glu Glu Met Tyr Ile Gln Gly Ile Val Glu Ala Val Glu Asn Gln Ser Cys Asp Lys Leu Ala Cys Phe Leu Glu Leu Lys Lys Glu Gln Val Leu Leu Leu Lys Arg Leu Ser Asp His Ile Leu Asn Arg Thr Ser Gly Asn Tyr Phe Arg Asn His Val Leu Leu Asp Val Leu Val Met Tyr Lys Lys Tyr Asn Glu Glu Phe Gly Glu Asp Thr Ala Phe Gly Asn Glu Cys Ala Gln Leu Cys Leu Glu Ile Val Gln Leu Met Tyr Glu Leu Phe Ser Cys Thr Thr Asn Ile Val Val Leu Ile Glu Ser Glu Ala Asp Pro Glu Asp Glu Ile Asn Leu Leu Leu Ala His Leu Glu 1308 SEQ.LISTING.txt Arg Ser Lys Tyr Ile Ala Thr Glu Lys Val Cys Lys Phe Gly Lys Thr Pro Arg Leu Gln Phe Ser Ile Cys Thr <210> 36 <211> 623 <212> DNA
<213> AsGV
<400> 36 atggcttgca tacccgcaga ttcaaaagca ttcataaaac cttttgaggg aacagacgtt 60 acgtgcttag tagcagactg tgtcgtttgg tttggcgccg atgagatcag ctccatattg 120 aatctcaacc tttgtaattc cataaaacat ctaccctaca atcagaaatg cttatggaaa 180 gatttagaac cacaagttaa cagtgaaaaa caatttgtga gcggtttggg tgtgaggttg 240 ttaattgcaa aaacacaaga ggtgggagga gatgatttta ggagaagaag gagtagtcgc 300 ggaaggagaa gaagaagtag ccattgcaat aaacgcagaa gcagtcgttg cggaagacgc 360 agaagttcca gtcgagaaag gagaaactct agagactgtt tggcgtatta taacaacacc 420 ccattagaca taccgtgtgc gccgctctct tgtacgcttc cccccaggtt tgaacttagt 480 gaatgcatgc ataagctcgg taacattttt atcaacgagg ccatttatga ttcacgagcc 540 tatcccgatt tagataatat taattacaag attaacaaga tatatgatct tgtattggat 600 aaaagtaatg tgataacgta act 623 <210> 37 <211> 208 <212> PRT
<213> AsGV
<400> 37 Met Ala Cys Ile Pro Ala Asp Ser Lys Ala Phe Ile Lys Pro Phe Glu Gly Thr Asp Val Thr Cys Leu Val Ala Asp Cys Val Val Trp Phe Gly Ala Asp Glu Ile Ser Ser Ile Leu Asn Leu Asn Leu Cys Asn Ser Ile Lys His Leu Pro Tyr Asn Gln Lys Cys Leu Trp Lys Asp Leu Glu Pro Gln Val Asn Ser Glu Lys Gln Phe Val Ser Gly Leu Gly Val Arg Leu Leu Ile Ala Lys Thr Gln Glu Val Gly Gly Asp Asp Phe Arg Arg Arg Arg Ser Ser Arg Gly Arg Arg Arg Arg Ser Ser His Cys Asn Lys Arg Arg Ser Ser Arg Cys Gly Arg Arg Arg Ser Ser Ser Arg Glu Arg Arg Asn Ser Arg Asp Cys Leu Ala Tyr Tyr Asn Asn Thr Pro Leu Asp Ile 1308 SEQ.LISTING.txt Pro Cys Ala Pro Leu Ser Cys Thr Leu Pro Pro Arg Phe Glu Leu Ser Glu Cys Met His Lys Leu Gly Asn Ile Phe Ile Asn Glu Ala Ile Tyr Asp Ser Arg Ala Tyr Pro Asp Leu Asp Asn Ile Asn Tyr Lys Ile Asn Lys Ile Tyr Asp Leu Val Leu Asp Lys Ser Asn Val Ile Thr Cys Thr <210> 38 <211> 676 <212> DNA
<213> AsGV
<400> 38 atgtttggtg ccatcgtatt attgttggta attggcgctg ttctatacct attgtacagt 60 aatgataaac taaacggaga ttcaattaat aactcatctg accaatcagg ggattctatg 120 gattcgttgc aggtagaaaa acaaaatgct aataatgtaa gaacgatatc tccaaaccga 180 gttaaaaatg tacgcttggc gcacggagat aatctcttta gtaaattaac cgtcaccgag 240 gcaccaatct cttatgatca agcggttaat cacggcgatc gtttaggcgc aaataccgta 300 ttcttgggcg tgctggacca gcctttaggt ggtttgccaa atttaaatag acagaccgct 360 aatgtaacaa taaagcaatt caaaaatcta tttataatgt ttaaaggact ggactttgtg 420 gagattgata acaacaattt aatggttcgt tatgaggtgg gtagcctagt ctacgctctt 480 atcgatgcat caaacgccac ccttccagat ttgttgcgcg acgtcaacta tcctatcgta 540 gttctcacaa ataactctag tgctcagcta gttcttaaag aatggggata cactcaaata 600 aataacagcg gaactctctt tgttaaaaat gaaaaaagtt ttaggttgca ataaaaaaag 660 tattaattaa ataact 676 <210> 39 <211> 215 <212> PRT
<213> AsGV
<400> 39 Met Phe Gly Ala Ile Val Leu Leu Leu Val Ile Gly Ala Val Leu Tyr Leu Lys Asn Asp Lys Leu Asn Gly Asp Ser Ile Asn Asn Ser Ser Asp Gln Ser Gly Asp Ser Met Asp Ser Leu Gln Val Glu Lys Gln Asn Ala Asn Asn Val Arg Thr Ile Ser Pro Asn Arg Val Lys Asn Val Arg Leu Ala His Gly Asp Asn Leu Phe Ser Lys Leu Thr Val Thr Glu Ala Pro Ile Ser Tyr Asp Gln Ala Val Asn His Gly Asp Arg Leu Gly Ala Asn 1308 SEQ.LISTING.txt Thr Val Phe Leu Gly Val Leu Asp Gln Pro Leu Gly Gly Leu Pro Asn Leu Asn Arg Gln Thr Ala Asn Val Thr Ile Lys Gln Phe Lys Asn Leu Phe Ile Met Phe Lys Gly Leu Asp Phe Val Glu Ile Asp Asn Asn Asn Leu Met Val Arg Tyr Glu Val Gly Ser Leu Val Tyr Ala Leu Ile Asp Asn Ala Thr Leu Pro Asp Leu Leu Arg Asp Val Asn Tyr Pro Ile Val Val Leu Thr Asn Asn Ser Ser Ala Gln Leu Val Leu Lys Glu Trp Gly Tyr Thr Gln Ile Asn Asn Ser Gly Thr Leu Phe Val Lys Asn Glu Lys Ser Phe Arg Leu Gln Cys Thr <210> 40 <211> 2210 <212> DNA
<213> AsGV
<400> 40 atggaaccgt tgactcgtta tcgcggtgtc gatataacac caacacaagt gcacaatttg 60 atcaagacaa tagcgcgtca aggaacaact atcagatatg gttgcgccaa caacaatgat 120 ttcgaaagga aggtgcgcga cattttattg gcttatcatc cacaattaca cgggttatca 180 acagatcagt tgttgattcg agccttaagc aatacaaaga acaaagagac cacttataat 240 tataattaca ttacaaaaac cgaacatggt gggagtgagg aggaaaacgg tataattaat 300 gtagacaaag aagttgtgtc cgataatctt ttatttgtat taaaaagcgt tttgggtgtg 360 aaaaaactag atcgagacga atgcatacgc ttggtgggta atataaaaaa atttgtagat 420 cggtggaagc gtgatgataa cgacgaccct gaaagtattt taaagtgttt ttctaatatt 480 gatcacgctt tacaatcctt agaggagaga aagaatgatt tcgaaaaaaa aaccaaaatg 540 ttagaggaag agtttaaaaa aaccaatgtg tatgagagag aattaaatga ttgtaagact 600 caacttcaaa tcgagctaaa taaccacgat gccaaccaag aaattttaaa aaaaaatata 660 gacgagctta acaatgttat taacagtcaa aaaatgacca tttctgtaaa taccggtcaa 720 ttgttaaaga tggctaacga ggtgggtgaa aaagaggaga gaattgaagt tttggtgagg 780 agatgtgaag agcttgaaaa tgagaatttt aatcttattc aaaaaattge gtcttacgag 840 gccaacttga aaattcaatc cgaagattta attgtgttaa aacacgaaag agactcattt 900 gaatcgaaat gtttagctct tcaagaacgt tgcgcacaaa ataacgacga gcaaagtcaa 960 atatatctca gcactttgac aaaattacaa gaagcgcgtt cagtaaatga aaatttacag 1020 ataatacaca aagagacgat tcaaaaactt aaaaatactc tcgaaaaaaa tagtgaatta 1080 gaggaagaaa agaaaacgtt aaacactaaa ctgttacaat tcgaagaacg tgagcgatac 1140 tattcaaaca tgtacgatca aaacagagag gaattgcaag cgtgtaaaat gagactgata 1200 gataaagaac aagaattgaa tagaaacgag caaagtgtga ccgaatacat gatgcaagtt 1260 aaaaatttga caatacaaaa caatgagtta aaagaacaga tttctagtaa agacgaagat 1320 gttaaaaaaa tttatgaaga aggacatgcc gctatcgagt ggcagtacaa aagagaaaac 1380 gaaatgaaaa aagatttgga agagatgagt aaaaaattgg ataaattaaa agagcacatc 1440 1308 SEQ.LISTING.txt aaaaagatta cgaaagatca tgaagaggag ttggagtata agaacgaaga acaaaaaaat 1500 atattaaata atgttgtaaa actacaaagt ttggtgcaag aggacaaagc taaatgggaa 1560 gagaagttaa atatgttgga gattgaaaat tcaaaattgc gcatttttaa agcagacgac 1620 caaaacgagg tggatcagtt gagtaaacat ttaaccctaa aagaggggga acttaacgcg 1680 gagaagcttc aaaacgataa acttgtcaaa gaaatcgatt tgctacaagc acaattaaaa 1740 gaaacgcgag caaacttaaa agagcgcaca accgaagtgg cacatttatc gagagagatt 1800 gaagagctgt atcatcgaga caaaaagagt gttgaaaatg caactaatag taatatatta 1860 aagcaggtga aaaaaaactt ggctcgttac agaaaaattg aaaacaacga agaaccaaaa 1920 cgaaaaatac ccaaatctaa tctatcttgg aatgtaaaca aactatataa cgttagcacc 1980 gaagaggagc ttcaaaaatt aataagggaa ataaaacaaa agaacgttaa ccacaagcgt 2040 tgggatacat atgcacaatt tttgagtaac gacactcttt ctgatttaaa aaaacgtcct 2100 gattataatt tactagatga cgactttaaa gagttgttag aaaaaaaaca tcaaatagaa 2160 tcaaatagtt ttattacaaa agaagaacaa tcattatttt catcttaact 2210 <210> 41 <211> 737 <212> PRT
<213> AsGV
<400> 41 Met Glu Pro Leu Thr Arg Tyr Arg Gly Val Asp Ile Thr Pro Thr Gln Val His Asn Leu Ile Lys Thr Ile Ala Arg Gln Gly Thr Thr Ile Arg Tyr Gly Cys Ala Asn Asn Asn Asp Phe Glu Arg Lys Val Arg Asp Ile Leu Leu Ala Tyr His Pro Gln Leu His Gly Leu Ser Thr Asp Gln Leu Leu Ile Arg Ala Leu Ser Asn Thr Lys Asn Lys Glu Thr Thr Tyr Asn Tyr Asn Tyr Ile Thr Lys Thr Glu His Gly Gly Ser Glu Glu Glu Asn Gly Ile Ile Asn Val Asp Lys Glu Val Val Ser Asp Asn Leu Leu Phe Val Leu Lys Ser Val Leu Gly Val Lys Lys Leu Asp Arg Asp Glu Cys Ile Arg Leu Val Gly Asn Ile Lys Lys Phe Val Asp Arg Trp Lys Arg Asp Asp Asn Asp Asp Pro Glu Ser Ile Leu Lys Cys Phe Ser Asn Ile Asp His Ala Leu Gln Ser Leu Glu Glu Arg Lys Asn Asp Phe Glu Lys Lys Thr Lys Met Leu Glu Glu Glu Phe Lys Lys Thr Asn Val Tyr Glu Arg Glu Leu Asn Asp Cys Lys Thr Gln Leu Gln Ile Glu Leu Asn Asn His Asp Ala Asn Gln Glu Ile Leu Lys Lys Asn Ile Asp Glu Leu Asn 1308 SEQ.LISTING.txt Asn Val Ile Asn Ser Gln Lys Met Thr Ile Ser Val Asn Thr Gly Gln Leu Leu Lys Met Ala Asn Glu Val Gly Glu Lys Glu Glu Arg Ile Glu Val Leu Val Arg Arg Cys Glu Glu Leu Glu Asn Glu Asn Phe Asn Leu Ile Gln Lys Ile Ala Ser Tyr Glu Ala Asn Leu Lys Ile Gln Ser Glu Asp Leu Ile Val Leu Lys His Glu Arg Asp Ser Phe Glu Ser Lys Cys Leu Ala Leu Gln Glu Arg Cys Ala Gln Asn Asn Asp Glu Gln Ser Gln Ile Tyr Leu Ser Thr Leu Thr Lys Leu Gln Glu Ala Arg Ser Val Asn Glu Asn Leu Gln Ile Ile His Lys Glu Thr Ile Gln Lys Leu Lys Asn Thr Leu Glu Lys Asn Ser Glu Leu Glu Glu Glu Lys Lys Thr Leu Asn Thr Lys Leu Leu Gln Phe Glu Glu Arg Glu Arg Tyr Tyr Ser Asn Met Tyr Asp Gln Asn Arg Glu Glu Leu Gln Ala Cys Lys Met Arg Leu Ile Asp Lys Glu Gln Glu Leu Asn Arg Asn Glu Gln Ser Val Thr Glu Tyr Met Met Gln Val Lys Asn Leu Thr Ile Gln Asn Asn Glu Leu Lys Glu Gln Ile Ser Ser Lys Asp Glu Asp Val Lys Lys Ile Tyr Glu Glu Gly His Ala Ala Ile Glu Trp Gln Tyr Lys Arg Glu Asn Glu Met Lys Lys Asp Leu Glu Glu Met Ser Lys Lys Leu Asp Lys Leu Lys Glu His Ile Lys Lys Ile Thr Lys Asp His Glu Glu Glu Leu Glu Tyr Lys Asn Glu Glu Gln Lys Asn Ile Leu Asn Asn Val Val Lys Leu Gln Ser Leu Val Gln Glu Asp Lys Ala Lys Trp Glu Glu Lys Leu Asn Met Leu Glu Ile Glu Asn Ser Lys Leu Arg Ile Phe Lys Ala Asp Asp Gln Asn Glu Val Asp Gln Leu Ser Lys His Leu Thr Leu Lys Glu Gly Glu Leu Asn Ala Glu Lys Leu Gln Asn Asp Lys Leu Val Lys Glu Ile Asp Leu Leu Gln Ala Gln Leu Lys Glu Thr Arg Ala Asn Leu Lys Glu Arg Thr Thr Glu Val Ala His Leu Ser Arg Glu Ile Glu Glu Leu Tyr His Arg Asp Lys 1308 SEQ.LISTING.txt Lys Ser Val Glu Asn Ala Thr Asn Ser Asn Ile Leu Lys Gln Val Lys Lys Asn Leu Ala Arg Tyr Arg Lys Ile Glu Asn Asn Glu Glu Pro Lys Arg Lys Ile Pro Lys Ser Asn Leu Ser Trp Asn Val Asn Lys Leu Tyr Asn Val Ser Thr Glu Glu Glu Leu Gln Lys Leu Ile Arg Glu Ile Lys Gln Lys Asn Val Asn His Lys Arg Trp Asp Thr Tyr Ala Gln Phe Leu Ser Asn Asp Thr Leu Ser Asp Leu Lys Lys Arg Pro Asp Tyr Asn Leu Leu Asp Asp Asp Phe Lys Glu Leu Leu Glu Lys Lys His Gln Ile Glu Ser Asn Ser Phe Ile Thr Lys Glu Glu Gln Ser Leu Phe Ser Ser Cys Thr <210> 42 <211> 308 <212> DNA
<213> AsGV
<400> 42 atggtacctt ttacgaatgt aattttcgta aatgctccca ttaaaaggct caatatcgct 60 ctcgaaacta tggtcaatgt aaatttgacc aatacggtta ctgcacgcct tatcgtaacc 120 gtctcgaatg aaaagcatat cgttattagt gatcataact ttgtagttgg cacaaaagta 180 ttcttcgggt ccatatttct tgtttgcaaa ctcaaatttg gtgctgtctg caatactctt 240 taaataaccc tttgacatta tttccgcctc gttcattatg tacaactgag actcaaatct 300 cttaatct 308 <210> 43 <211> 82 <212> PRT
<213> AsGV
<400> 43 Met Val Pro Phe Thr Asn Val Ile Phe Val Asn Ala Pro Ile Lys Arg Leu Asn Ile Ala Leu Glu Thr Met Val Asn Val Asn Leu Thr Asn Thr Val Thr Ala Arg Leu Ile Val Thr Val Ser Asn Glu Lys His Ile Val Ile Ser Asp His Asn Phe Val Val Gly Thr Lys Val Phe Phe Gly Ser Ile Phe Leu Val Cys Lys Leu Lys Phe Gly Ala Val Cys Asn Thr Leu 1308 SEQ.LISTING.txt Cys Thr <210> 44 <211> 449 <212> DNA
<213> AsGV
<400> 44 atgaactttg attatttaaa agacttggtt agtttaaatc ctattaaaat tacttttgtg 60 tccaaaaacc tccgcagcaa tcttcaattt attttagagg atcatgaaaa agagaagagg 120 ttcgatccag acgaacaaac actgttgaac aagctacaca ggatactctt gttgttttta 180 caagataaac tcgacgaaga caccttgttt caattgtttg gatacaaatt agacttacaa 240 cgagatcagt ttaggtattt gtacgacaaa ataaaagaag atattggttt aagaaatata 300 ataaacataa ttacaaatgt gctaaacacc tcggatcatg aagaaataaa aaatagatta 360 caaattgcgt tagaagagga cgactgttat tcgtatattg ctagtttttt aattagagaa 420 tgtaacaatg caataaaata tatttaact 449 <210> 45 <211> 146 <212> PRT
<213> AsGV
<400> 45 Met Asn Phe Asp Tyr Leu Lys Asp Leu Val Ser Leu Asn Pro Ile Lys Ile Thr Phe Val Ser Lys Asn Leu Arg Ser Asn Leu Gln Phe Ile Asp His Glu Lys Glu Lys Arg Phe Asp Pro Asp Glu Gln Thr Leu Leu Asn Lys Leu His Arg Ile Leu Leu Leu Phe Leu Gln Asp Lys Leu Asp Glu Asp Thr Leu Phe Gln Leu Phe Gly Tyr Lys Leu Asp Leu Gln Arg Asp Gln Phe Arg Tyr Leu Tyr Asp Lys Ile Lys Glu Asp Ile Gly Leu Arg Asn Ile Ile Asn Ile Ile Thr Asn Val Leu Asn Thr Ser Asp His Glu Glu Ile Lys Asn Arg Leu Gln Ile Ala Leu Glu Glu Asp Asp Cys Tyr Ile Ala Ser Phe Leu Ile Arg Glu Cys Asn Asn Ala Ile Lys Tyr Ile Cys Thr <210> 46 <211> 488 <212> DNA
<213> AsGV
1308 SEQ.LISTING.txt <400> 46 atgtttatgg acatagtggt tgttcctctg ttgtttttag ctattttcgc gttactagta 60 atcacacttc tattcaatcc tgtcgaagat tttgctgccg aaatggtaga ggctactgtt 120 gtcaatgttt tgcccttgat taatgttttt gaaaagggta acgataggct ttttgtaatc 180 gagcccgaaa agagtgtgat atataatacg cacggcgctt tatattatta ctttgaaggg 240 ggtgtgagtg gacgtctatg tccgcacaac gaatacgctg tagtgcgaat aacggcagcg 300 gacatcgagc taataaacga aaccggcgta tacgatatct attgtagtcc cgtgggatcg 360 agaactatat atagccattt tacatctgat tcctttagat atcaggctat tttacccaaa 420 atgacctata cccttctgga tgttttaaat tatcttatcg aaacgggttt tgctctggtg 480 tattgact 488 <210> 47 <211> 163 <212> PRT
<213> AsGV
<400> 47 Met Phe Met Asp Ile Val Val Val Pro Leu Leu Phe Leu Ala Ile Phe Ala Leu Leu Val Ile Thr Leu Leu Phe Asn Pro Val Glu Asp Phe Ala Ala Glu Met Val Glu Ala Thr Val Val Asn Val Leu Pro Leu Ile Asn Val Phe Glu Lys Gly Asn Asp Arg Leu Phe Val Ile Glu Pro Glu Lys Ser Val Ile Tyr Asn Thr His Gly Ala Leu Tyr Tyr Tyr Phe Glu Gly Gly Val Ser Gly Arg Leu Cys Pro His Asn Glu Tyr Ala Val Val Arg Ile Thr Ala Ala Asp Ile Glu Leu Ile Asn Glu Thr Gly Val Tyr Asp Ile Tyr Cys Ser Pro Val Gly Ser Arg Thr Ile Tyr Ser His Phe Thr Ser Asp Ser Phe Arg Tyr Gln Ala Ile Leu Pro Lys Met Thr Tyr Thr Leu Leu Asp Val Leu Asn Tyr Leu Ile Glu Thr Gly Phe Ala Leu Val Tyr Cys Thr <210> 48 <211> 771 <212> DNA
<213> AsGV
1308 SEQ.LISTING.txt <400> 48 atgtccctta acggaggccc acttattgcg caaaacgatc cactccattt gagaaaaata 60 ttcgatatat ttgcagactt tagacgtcgg gaggactata gcggtcttgt ggaacactta 120 attacgactt atccggaaaa tgtcaagaat cggactttta acttttccaa tacgggccat 180 acgttccaca tgctgtacgc gtatgtgccg tcgctatcca acaaggagcg aaagcaaata 240 cgattggacg gtataaaaaa gttaatgaag agcaccagca acctttttgc catgtatgaa 300 gatgtgttta agtgtatgaa agagggatta atagaggaat cctgcccttg tgttgctata 360 aaatctcgtt tgcaggagaa cattgcgtat aacgagtggt tgtccaataa aaattttgac 420 agcaaacctc tcaagttgaa aaaagatccc atagacaaca ttcttttcaa gtacagcgtc 480 aactggaaac agagcttaaa aaagaaaaaa aatgttgctg taaaaaatga agtaaaaata 540 aaaaagtgtg aagtaataaa aaaagaactg ttgtgcttca cgaccttagc taaaaaactc 600 tctccttctt cgctagacga aattaatggg cgcaccgttg tgacgtgttc gcacgagttt 660 acaatacaag agaaacagct aagggcgggg gatgaggctg tgtcttttgt gaatgtatgt 720 tcagtgtgtg ggttggtgaa aaaagaagaa aattagttta ccatagtaac t 771 <210> 49 <211> 253 <212> PRT
<213> AsGV
<400> 49 Met Ser Leu Asn Gly Gly Pro Leu Ile Ala Gln Asn Asp Pro Leu His Leu Arg Lys Ile Phe Asp Ile Phe Ala Asp Phe Arg Arg Arg Glu Asp Tyr Ser Gly Leu Val Glu His Leu Ile Thr Thr Tyr Pro Glu Asn Val Lys Asn Arg Thr Phe Asn Phe Ser Asn Thr Gly His Thr Phe His Met Leu Tyr Ala Tyr Val Pro Ser Leu Ser Asn Lys Glu Arg Lys Gln Ile Arg Leu Asp Gly Ile Lys Lys Leu Met Lys Ser Thr Ser Asn Leu Phe Ala Met Tyr Glu Asp Val Phe Lys Cys Met Lys Glu Gly Leu Ile Glu Glu Ser Cys Pro Cys Val Ala Ile Lys Ser Arg Leu Gln Glu Asn Ile Ala Tyr Asn Glu Trp Leu Ser Asn Lys Asn Phe Asp Ser Lys Pro Leu Lys Leu Lys Lys Asp Pro Ile Asp Asn Ile Leu Phe Lys Tyr Ser Val Asn Trp Lys Gln Ser Leu Lys Lys Lys Lys Asn Val Ala Val Lys Asn Glu Val Lys Ile Lys Lys Cys Glu Val Ile Lys Lys Glu Leu Leu Cys 1308 SEQ.LISTING.txt Phe Thr Thr Leu Ala Lys Lys Leu Ser Pro Ser Ser Leu Asp Glu Ile Asn Gly Arg Thr Val Val Thr Cys Ser His Glu Phe Thr Ile Gln Glu Lys Gln Leu Arg Ala Gly Asp Glu Ala Val Ser Phe Val Asn Val Cys Ser Val Cys Gly Leu Val Lys Lys Glu Glu Asn Cys Thr <210> 50 <211> 3021 <212> DNA
<213> AsGV
<400> 50 atgtcgattc aacgcacctc ctctaatttt atcgtacccc gcttaaactt acccgcttgg 60 attaaagaag gtaaaagtta tttagcttgt ttacataaaa aatctcctct tggttatatc 120 ttacagccaa acacaaaaat cagttacaaa ttaagcagct caattgatac gggacacggt 180 agcccggtca ctctaaggtt tctcaataat gatagcaaaa ccgaaacatc tcttaccatt 240 aattcgttta ctgaaaacga atatattgtt caacaccaat gtgtcccttt tgttgactgg 300 gttttataca gacacgctgt tactatagaa ttcacaataa ctggtgaaca tacggtatta 360 cctcaaataa actatgtttt ctcaaataac gtacaaggct tttttactta cgacacccct 420 tatgcgttcg tacaatttgg aaaaattgtt gttttagttc caccttctgc gagattagct 480 tttataaatg ggaatagtga ttttttaaac aacatatacg atttttataa taatgcaata 540 tcaatctacg acaacctaat cggtcttaag gacggtatag cgttggctga tgttgacgca 600 aactttgata agcaaatgtt ttttaaacaa gatctcagcg ggtccggagc tgcttattat 660 ggaccgtttt ggattggtgt gaccacgcaa tctttcgatc ttttctacaa tgtctccatt 720 tcaaattgga taatgcttca tgtgatgggt cacgcctacg attttgagtt tgctaatagc 780 aaatcaatat ttgaagagac gtgggcgagc atatttgccg atagatatca attttttaga 840 tctaccaaaa tggaacgtta tctaacaaac acggtctttg gaccacaaat gtattcacaa 900 attattactg atatcaatat attgttctcg gccagaactc cttttcccgc ttggccagag 960 tttagaaagc ttttaatttt atctctaatt ttaaatacaa aacacggaga agatgggttt 1020 agagagttaa atcgctcatt tagacgaaag cagattggaa tggtatttga gagcggtcaa 1080 atcttctctt tgcttctgcg aaactactcg cattatgatc tttattatta tttcaaaatg 1140 atattacaag ttcccattac tgactattac atgcattaca ccaacgctga caatataact 1200 tttaaaccct actatcatca gtatgaaggg ttggctcgga ataaacaatg cttgaatagt 1260 ctaaacagtg aaattacaat aatgagctcc gaaagctttt cagaccattt aattaaaaca 1320 tattacgaca cccagttcgc tttggttacc ccaacggacg ttttacccta taataacggt 1380 tcgaccacat tttatattag agcggtcagt ggtacacata tatttaataa cgacttagtt 1440 ggtaaaacaa tcattataat gaacggtgat actgtggttg aagagtgtat aattcgtctt 1500 agtgggactt tatattttga gatgtctgta aacagaggtc tttttcacat tgtacatccg 1560 cgaggtaacc ttagatatta tgttcctgat aacacgagaa tagtaacaga tacaacaatt 1620 aaagcaaccg acgtccagaa cgtcgacgct gtacaatatt atctacgacc gtacgtgtat 1680 tccgaattag aaattgaaac gggccacgta ttaggagagg ctaacgttta cgcggccact 1740 atacatatta actataaaga tagaacgata tcgatacaag tgttcgatgc aaatcctgtt 1800 ccttcgtttc ccaattcaat actatttaga ctacgtttac acaatgttgt tacaatgcaa 1860 gaggagagtt ttgttttgaa tggaatcaat gctaacatta atctacaaga agaatacgtt 1920 1308 SEQ.LISTING.txt ttaaagtaca acatcaatga tcgattagag cttacctaca acaatctcgc cacaggaaac 1980 aatactttac aaattatgta ctttttagag acccgtatac aaaacagcac aacatttact 2040 tatgttttgt tagaggacga tatatatccc gaacaaaacg cgcttcatta tccatctaaa 2100 ctgcagcgtt taatgaaacg aatagataaa ctcacggcct ggctagacaa tcgtcccaag 2160 atgcttaaat acgattcaaa attacgcgaa tcgatttacc tttgctggga caagcttaaa 2220 gataatgaat ataaagatag tttaataaaa tacttaccca actcgttgcg cgacagcaca 2280 gaatatcatt tagaagccct aacgatatac aatcatgtca ttgcagatat taaatataac 2340 gctttactaa acaggtgtat tatcaactat tataaacatt ttgatgcaat acatgtcttt 2400 tttcatcaaa tatatttcgg aatgcaaatt aagaatcccc tgggacaaat tatttacaaa 2460 aagctgttta gaggcagtca tgagatgact gacgcgtttt tatcatttcc tttgtgtgac 2520 ggtagcgtgg ttcaaatatt tcatcgcgaa ccaggccgtt tgttacttta caaggaaaat 2580 gtacgagaac ctgtagactt tcaacaagac acatatttgt tagttaaaaa cgcaaaatta 2640 catttaatac ctgatatgcc tagcatttta cccatttttc ctaccccccc acctactcct 2700 gaacctactc ccccacctac tcctgaacct actcccccac ctactcctga acctactccc 2760 ccacctactc ctgaacctac tcccccacct actcctgaac ctactccccc acctactcct 2820 gaacctactc ctccacctac tcctgaacct actcctccac ctactcctga acctactcct 2880 ccacctactc ctgaacctac tccagcacct actcctgaac ctactccccc acctactcct 2940 gaacctactc ccccacctac tccttctcca ccacccacac ctccatcgac cccaccattg 3000 ttcttccgtt tttaggtagc t 3021 <210> 51 <211> 1004 <212> PRT
<213> AsGV
<400> 51 Met Ser Ile Gln Arg Thr Ser Ser Asn Phe Ile Val Pro Arg Leu Asn Leu Pro Ala Trp Ile Lys Glu Gly Lys Ser Tyr Leu Ala Cys Leu His Lys Lys Ser Pro Leu Gly Tyr Ile Leu Gln Pro Asn Thr Lys Ile Ser Tyr Lys Leu Ser Ser Ser Ile Asp Thr Gly His Gly Ser Pro Val Thr Leu Arg Phe Leu Asn Asn Asp Ser Lys Thr Glu Thr Ser Leu Thr Ile 65 70 ?5 80 Asn Ser Phe Thr Glu Asn Glu Tyr Ile Val Gln His Gln Cys Val Pro Phe Val Asp Trp Val Leu Tyr Arg His Ala Val Thr Ile Glu Phe Thr Ile Thr Gly Glu His Thr Val Leu Pro Gln Ile Asn Tyr Val Phe Ser Asn Asn Val Gln Gly Phe Phe Thr Tyr Asp Thr Pro Tyr Ala Phe Val Gln Phe Gly Lys Ile Val Val Leu Val Pro Pro Ser Ala Arg Leu Ala Phe Ile Asn Gly Asn Ser Asp Phe Leu Asn Asn Ile Tyr Asp Phe Tyr 1308 SEQ.LISTING.txt Asn Asn Ala Ile Ser Ile Tyr Asp Asn Leu Ile Gly Leu Lys Asp Gly Ile Ala Asp Val Asp Ala Asn Phe Asp Lys Gln Met Phe Phe Lys Gln Asp Leu Ser Gly Ser Gly Ala Ala Tyr Tyr Gly Pro Phe Trp Ile Gly Val Thr Thr Gln Ser Phe Asp Leu Phe Tyr Asn Val Ser Ile Ser Asn Trp Ile Met Leu His Val Met Gly His Ala Tyr Asp Phe Glu Phe Ala Asn Ser Lys Ser Ile Phe Glu Glu Thr Trp Ala Ser Ile Phe Ala Asp Arg Tyr Gln Phe Phe Arg Ser Thr Lys Met Glu Arg Tyr Leu Thr Asn Thr Val Phe Gly Pro Gln Met Tyr Ser Gln Ile Ile Thr Asp Ile Asn Ile Leu Phe Ser Ala Arg Thr Pro Phe Pro Ala Trp Pro Glu Phe Arg Lys Leu Leu Ile Leu Ser Leu Ile Leu Asn Thr Lys His Gly Glu Asp Gly Phe Arg Glu Leu Asn Arg Ser Phe Arg Arg Lys Gln Ile Gly Met Val Phe Glu Ser Gly Gln Ile Phe Ser Leu Leu Leu Arg Asn Tyr Ser His Tyr Asp Leu Tyr Tyr Tyr Phe Lys Met Ile Leu Gln Val Pro Ile Thr Asp Tyr Tyr Met His Tyr Thr Asn Ala Asp Asn Ile Thr Phe Lys Pro Tyr Tyr His Gln Tyr Glu Gly Leu Ala Arg Asn Lys Gln Cys Leu Asn Ser Leu Asn Ser Glu Ile Thr Ile Met Ser Ser Glu Ser Phe Ser Asp His Leu Ile Lys Thr Tyr Tyr Asp Thr Gln Phe Ala Leu Val Thr Pro Thr Asp Val Leu Pro Tyr Asn Asn Gly Ser Thr Thr Phe Tyr Ile Arg Ala Val Ser Gly Thr His Ile Phe Asn Asn Asp Leu Val Gly Lys Thr Ile Ile Ile Met Asn Gly Asp Thr Val Val Glu Glu Cys Ile Ile Arg Leu Ser Gly Thr Leu Tyr Phe Glu Met Ser Val Asn Arg Gly Leu Phe His Ile Val His Pro Arg Gly Asn Leu Arg Tyr Tyr Val Pro Asp Asn Thr Arg Ile Val Thr Asp Thr Thr Ile Lys Ala Thr Asp Val Gln Asn Val Asp Ala Val Gln Tyr Tyr Leu Arg Pro Tyr Val Tyr Ser Glu 1308 SEQ.LISTING.txt Leu Glu Ile Glu Thr Gly His Val Leu Gly Glu Ala Asn Val Tyr Ala Ala Thr Ile His Ile Asn Tyr Lys Asp Arg Thr Ile Ser Ile Gln Val Phe Asp Ala Asn Pro Val Pro Ser Phe Pro Asn Ser Ile Leu Phe Arg Leu Arg Leu His Asn Val Val Thr Met Gln Glu Glu Ser Phe Val Leu Asn Gly Ile Asn Ala Asn Ile Asn Leu Gln Glu Glu Tyr Val Leu Lys Tyr Asn Ile Asn Asp Arg Leu Glu Leu Thr Tyr Asn Asn Leu Ala Thr Gly Asn Asn Thr Leu Gln Ile Met Tyr Phe Leu Glu Thr Arg Ile Gln Asn Ser Thr Thr Phe Thr Tyr Val Leu Leu Glu Asp Asp Ile Tyr Pro Glu Gln Asn Ala Leu His Tyr Pro Ser Lys Leu Gln Arg Leu Met Lys Arg Ile Asp Lys Leu Thr Ala Trp Leu Asp Asn Arg Pro Lys Met Leu Lys Tyr Asp Ser Lys Leu Arg Glu Ser Ile Tyr Leu Cys Trp Asp Lys Leu Lys Asp Asn Glu Tyr Lys Asp Ser Leu Ile Lys Tyr Leu Pro Asn Ser Leu Arg Asp Ser Thr Glu Tyr His Leu Glu Ala Leu Thr Ile Tyr Asn His Val Ile Ala Asp Ile Lys Tyr Asn Ala Leu Leu Asn Arg Cys Ile Ile Asn Tyr Tyr Lys His Phe Asp Ala Ile His Val Phe Phe His Gln Ile Tyr Phe Gly Met Gln Ile Lys Asn Pro Leu Gly Gln Ile Ile Tyr Lys Lys Leu Phe Arg Gly Ser His Glu Met Thr Asp Ala Phe Leu Ser Phe Pro Leu Cys Asp Gly Ser Val Val Gln Ile Phe His Arg Glu Pro Gly Arg Leu Leu Leu Tyr Lys Glu Asn Val Arg Glu Pro Val Asp Phe Gln Gln Asp Thr Tyr Leu Leu Val Lys Asn Ala Lys Leu His Leu Ile Pro Asp Met Pro Ser Ile Leu Pro Ile Phe Pro Thr Pro Pro Pro Thr Pro Glu Pro Thr Pro Pro Pro Thr Pro Glu Pro Thr Pro Pro Pro Thr Pro Glu Pro Thr Pro Pro Pro Thr Pro Glu Pro Thr Pro Pro Pro Thr Pro Glu Pro Thr Pro Pro Pro Thr Pro Glu Pro Thr Pro Pro Pro 1308 SEQ.LISTING.txt Thr Pro Glu Pro Thr Pro Pro Pro Thr Pro Glu Pro Thr Pro Pro Pro Thr Pro Glu Pro Thr Pro Ala Pro Thr Pro Glu Pro Thr Pro Pro Pro Thr Pro Glu Pro Thr Pro Pro Pro Thr Pro Ser Pro Pro Pro Thr Pro Pro Ser Thr Pro Pro Leu Phe Phe Arg Phe Cys Thr <210> 52 <211> 1076 <212> DNA
<213> AsGV
<400> 52 atggcttgtt caaatcaaat tatagtatat atcagcgatt tgtttgtaga ctttccttac 60 gacgttatcg aaacacaacg agacgcgggc ggggctgtta tcaccgacct tacaatattt 120 gtgcccacat ttgaagacga gaaggttatc aataccgaag ctctcaacat tagggggttt 180 acaacagtac gagtattgaa gcacgtaccc cgttttgaac cggacgaaca agaagctgta 240 ggtgtggtgg tttattggaa cgctattagc aacattacaa aactcggagt tggtaaaacc 300 aatgtttata acgtggtgct tagcgacaat cttttcggct gcaactcaat tactattcat 360 aatgtattac cagaagagtt gcggtgccct ctgcaagtag gcttaaggta taatcattca 420 aatgctcaca cgatccttgt gggcgagtta gctggagact cacaagaaat ggcaaaagcc 480 agagacgaaa acctggacga ctttgtaatt tgttttcgca aagaaacacc catgggaatt 540 aaaattttaa acaccaaaag atttcttata ttgttaagtg cgcgcaaaac gagagctcgt 600 ttctctgtct atctgaccaa tcaagagctt gccacagtgc acaaagagct ttcgtgggaa 660 agtactagac gtgttttaag gggcgggctg tcctcaaatt gtacggtgct taacaaaaaa 720 agttaccaat acgtcctaga cgcgctcgag cttctaggta tcgataacac ggacataagc 780 tctgttcata aacttttgga tgtgttcaat cctctaattt tacgttacaa attagtacca 840 gatgtcttta ttcagcttaa cttgataggt ggaaagaaca aacacgttcg tttgtattgt 900 aaacatgaag gggttgctat aacaaacgca ggaccggtcc ccattaacct acccactcgc 960 aacccaaaac cttttacaca tcacacttta aaaccaccat cggagcgtct ctaccaaatt 1020 cttggcactc gaaatgtgtt tcttcacaca ccaatatata attattttct gtaact 1076 <210> 53 <211> 357 <212> PRT
<213> AsGV
<400> 53 Met Ala Cys Ser Asn Gln Ile Ile Val Tyr Ile Ser Asp Leu Phe Val Asp Phe Pro Tyr Asp Val Ile Glu Thr Gln Arg Asp Ala Gly Gly Ala Val Ile Thr Asp Leu Thr Ile Phe Val Pro Thr Phe Glu Asp Glu Lys Val Ile Asn Thr Glu Ala Leu Asn Ile Arg Gly Phe Thr Thr Val Arg 1308 SEQ.LISTING.txt Val Leu Lys His Val Pro Arg Phe Glu Pro Asp Glu Gln Glu Ala Val Gly Val Val Val Tyr Trp Asn Ala Ile Ser Asn Ile Thr Lys Leu Gly Val Gly Lys Thr Asn Val Tyr Asn Val Val Leu Ser Asp Asn Leu Phe Gly Cys Asn Ser Ile Thr Ile His Asn Val Leu Pro Glu Glu Leu Arg Cys Pro Leu Gln Val Gly Leu Arg Tyr Asn His Ser Asn Ala His Thr Ile Leu Val Gly Glu Leu Ala Gly Asp Ser Gln Glu Met Ala Lys Ala Arg Asp Glu Asn Leu Asp Asp Phe Val Ile Cys Phe Arg Lys Glu Thr Pro Met Gly Ile Lys Ile Leu Asn Thr Lys Arg Phe Leu Ile Leu Leu Ser Ala Arg Lys Thr Arg Ala Arg Phe Ser Val Tyr Leu Thr Asn Gln Glu Leu Ala Thr Val His Lys Glu Leu Ser Trp Glu Ser Thr Arg Arg Val Leu Arg Gly Gly Leu Ser Ser Asn Cys Thr Val Leu Asn Lys Lys Ser Tyr Gln Tyr Val Leu Asp Ala Leu Glu Leu Leu Gly Ile Asp Asn Thr Asp Ile Ser Ser Val His Lys Leu Leu Asp Val Phe Asn Pro Leu Ile Leu Arg Tyr Lys Leu Val Pro Asp Val Phe Ile Gln Leu Asn Leu Ile Gly Gly Lys Asn Lys His Val Arg Leu Tyr Cys Lys His Glu Gly Val Ala Ile Thr Asn Ala Gly Pro Val Pro Ile Asn Leu Pro Thr Arg Asn Pro Lys Pro Phe Thr His His Thr Leu Lys Pro Pro Ser Leu Tyr Gln Ile Leu Gly Thr Arg Asn Val Phe Leu His Thr Pro Ile Tyr Asn Tyr Phe Leu Cys Thr <210> 54 <211> 515 <212> DNA
<213> AsGV
<400> 54 atgagtctaa aaactaaaga caccaagcca aaggcaagag atacattatt ctacacaaag 60 1308 SEQ.LISTING.txt cttcgtaaag acgcacatgc tcctgtacgg ggttcggtgg gagcggcggg gcttgactta 120 gccagtgttg aaaatatcca aattccgcca ggagaaaacg cgctagttcc cacggggctg 180 tcgatcgaaa ttccaaacga ttgctacgga agaattgcgc cacgttcggg tttggcgctg 240 aggtatagtg tctctgtaca tgccggagtc atcgatccgg actacagagg tcatctgcaa 300 gtgctacttt tcaatcatgg aaagaaaacg atggaaattt tgaaggggga tcgtattgcg 360 cagttggtgt gcgaaaagat ccgctttccc gaagctgtag aaaagccgaa actatcagaa 420 acggaccgtg ccgaaggagg gtttgggtcc acgggaattg ccagccaaca acaagaggaa 480 atttcaagtg aagaagagtg tgattgtcct taact 515 <210> 55 <211> 172 <212> PRT
<213> AsGV
<400> 55 Met Ser Leu Lys Thr Lys Asp Thr Lys Pro Lys Ala Arg Asp Thr Leu Phe Tyr Thr Lys Leu Arg Lys Asp Ala His Ala Pro Val Arg Gly Ser Val Gly Ala Ala Gly Leu Asp Leu Ala Ser Val Glu Asn Ile Gln Ile Pro Pro Gly Glu Asn Ala Leu Val Pro Thr Gly Leu Ser Ile Glu Ile Pro Asn Asp Cys Tyr Gly Arg Ile Ala Pro Arg Ser Gly Leu Ala Leu Arg Tyr Ser Val Ser Val His Ala Gly Val Ile Asp Pro Asp Tyr Arg Gly His Leu Gln Val Leu Leu Phe Asn His Gly Lys Lys Thr Met Glu Ile Leu Lys Gly Asp Arg Ile Ala Gln Leu Val Cys Glu Lys Ile Arg Phe Pro Glu Ala Val Glu Lys Pro Lys Leu Ser Glu Thr Asp Arg Ala Glu Gly Gly Phe Gly Ser Thr Gly Ile Ala Ser Gln Gln Gln Glu Glu Ile Ser Ser Glu Glu Glu Cys Asp Cys Pro Cys Thr <210> 56 <211> 812 <212> DNA
<213> AsGV
<400> 56 atgttttcta cactttcaca caacgctgaa gaagaacaga gtttttttga ggatgaattt 60 ttacgaatga gagatgtgaa caatcgactt aaaacttttt ctaactggaa ccacccaaac 120 atttcgaaag atgaagtttc acagagtgga ttctattgta aaggttccaa ctttttggtc 180 1308 SEQ.LISTING.txt gcttgtccgt tttgcaagat ggaaactaac ttagtgccag aggatataaa tgcttttgag 240 caacacaaac gatgggcacc gcagtgtaac tttgttcgga gccatttgaa cgattcttcc 300 ctctcttctt atgcgccgtt caaaaaaatt tacgaaaact tggaaaatcg cttagaaagc 360 tataaaactt ggcctgttag tataccgttg cgtcctaaag aattggcagc ggctggattt 420 tattacacag gccattcaga tcaagtgaat tgcttttatt gcggaggggg tttaagagat 480 tggaagactg gagacgatcc ttggcaacag cacgcgcgct ggtttgataa gtgtctgttt 540 ttaatcggca agaaaggtac ggactacatt caaaaagtaa tgaccgaagc ttgcagtatt 600 aaagagaacg agcgttttcc gatagtggaa acaaaaatta aggaagaggg aaaaaacaag 660 tgcgccattt gttgtaccga agaggctgtc atcgcattcg ttccttgtgg tcatatttct 720 acgtgtgccg attgtgctat aagtttcaaa aattgtataa tgtgtcgtac caaaattgaa 780 tccaaactta gaatttatta tactgtttaa ct 812 <210> 57 <211> 267 <212> PRT
<213> AsGV
<400> 57 Met Phe Ser Thr Leu Ser His Asn Ala Glu Glu Glu Gln Ser Phe Phe Glu Asp Glu Phe Leu Arg Met Arg Asp Val Asn Asn Arg Leu Lys Thr Phe Ser Asn Trp Asn His Pro Asn Ile Ser Lys Asp Glu Val Ser Gln Ser Gly Phe Tyr Cys Lys Gly Ser Asn Phe Leu Val Ala Cys Pro Phe Cys Lys Met Asn Leu Val Pro Glu Asp Ile Asn Ala Phe Glu Gln His Lys Arg Trp Ala Pro Gln Cys Asn Phe Val Arg Ser His Leu Asn Asp Ser Ser Leu Ser Ser Tyr Ala Pro Phe Lys Lys Ile Tyr Glu Asn Leu Glu Asn Arg Leu Glu Ser Tyr Lys Thr Trp Pro Val Ser Ile Pro Leu Arg Pro Lys Glu Leu Ala Ala Ala Gly Phe Tyr Tyr Thr Gly His Ser Asp Gln Val Asn Cys Phe Tyr Cys Gly Gly Gly Leu Arg Asp Trp Lys Thr Gly Asp Asp Pro Trp Gln Gln His Ala Arg Trp Phe Asp Lys Cys Leu Phe Leu Ile Gly Lys Lys Gly Thr Asp Tyr Ile Gln Lys Val Met Thr Glu Ala Cys Ser Ile Lys Glu Asn Glu Arg Phe Pro Ile Val Glu Thr Lys Ile Lys Glu Glu Gly Lys Asn Lys Cys Ala Ile Cys Cys Thr Glu Glu Ala Val Ile Ala Phe Val Pro Cys Gly His Thr Cys Ala Asp 1308 SEQ.LISTING.txt Cys Ala Ile Ser Phe Lys Asn Cys Ile Met Cys Arg Thr Lys Ile Glu Ser Lys Leu Arg Ile Tyr Tyr Thr Val Cys Thr <210> 58 <211> 1061 <212> DNA
<213> AsGV
<400> 58 atgtcgttct ttagaggtct aagacgaacc aataaaacat atcccaatgt aaactcattc 60 atttccgacc acaataattt gattgcaaat gtcacaccca gcggttttaa tttaggaccc 120 ccttcaggtt taactttagg tccgaacaga gttcagcccg gttacaatat taacaacact 180 tttgtaccca attcagacat taatagaatc atgagaacta acaatccgac cggtatgagg 240 accctctttc ccaacgcaaa taacagccag attaatggtt tgagcagatt acgtgccgca 300 gataatattc cagatgctca aatttatggt ttacaacagc gaaaaaattc agtgaaaaat 360 tctcatccag atctggccac tagggatccc actcaaattg aggccgcctt aaacaacaat 420 cctagacttt ctacatactt gaagggtctc ggtaccgtcg ctttagtggg cgctggtgtt 480 tatttaataa ttcagggcgg taacttagta gcttctattg ttgccgcatt aaatcgcacg 540 ggtggatctt attactttag aggtaacaac ggggccgaaa gttttaataa catagagagc 600 tgcattttga gacatcgaac ttgcggtgta ttgttggaag acatacagcc gtatctatgt 660 cagtttgacc cgttagatct cgccaatcag gaccccatac tacctcccga ccaggcgagg 720 gaaatatgcg taggatataa ccgagaaaga gaacaaaccg tatgcagagc ttcggatagc 780 aacgctcatc cagactctcc ggcatatttt gatattagcg atttagatgt caatcagacc 840 atacaatgtt tggagcccta cgattttgcc gatttggtag cggatttggg tttagacggt 900 ctacttggtg aaaacggcct catttctaac atgtccaata gtctaaacag catttctgaa 960 aattttatga ccatcctttt cgttatcggc ggtattgtac ttttattatt tattggtttt 1020 atgatattta gggtgagtat gagtaaaaag tccgagtaac t 1061 <210> 59 <211> 352 <212> PRT
<213> AsGV
<400> 59 Met Ser Phe Phe Arg Gly Leu Arg Arg Thr Asn Lys Thr Tyr Pro Asn Val Asn Ser Phe Ile Ser Asp His Asn Asn Leu Ile Ala Asn Val Thr Pro Ser Gly Phe Asn Leu Gly Pro Pro Ser Gly Leu Thr Leu Gly Pro Asn Arg Val Gln Pro Gly Tyr Asn Ile Asn Asn Thr Phe Val Pro Asn Ser Asp Ile Asn Arg Ile Met Arg Thr Asn Asn Pro Thr Gly Met Arg Thr Leu Phe Pro Asn Ala Asn Asn Ser Gln Ile Asn Gly Leu Ser Arg 1308 SEQ.LISTING.txt Leu Arg Ala Ala Asp Asn Ile Pro Asp Ala Gln Ile Tyr Gly Leu Gln Gln Arg Lys Asn Ser Val Lys Asn Ser His Pro Asp Leu Ala Thr Arg Asp Pro Thr Gln Ile Glu Ala Ala Leu Asn Asn Asn Pro Arg Leu Ser Thr Tyr Leu Lys Gly Leu Gly Thr Val Val Gly Ala Gly Val Tyr Leu Ile Ile Gln Gly Gly Asn Leu Val Ala Ser Ile Val Ala Ala Leu Asn Arg Thr Gly Gly Ser Tyr Tyr Phe Arg Gly Asn Asn Gly Ala Glu Ser Phe Asn Asn Ile Glu Ser Cys Ile Leu Arg His Arg Thr Cys Gly Val Leu Leu Glu Asp Ile Gln Pro Tyr Leu Cys Gln Phe Asp Pro Leu Asp Leu Ala Asn Gln Asp Pro Ile Leu Pro Pro Asp Gln Ala Arg Glu Ile Cys Val Gly Tyr Asn Arg Glu Arg Glu Gln Thr Val Cys Arg Ala Ser Asp Ser Asn Ala His Pro Asp Ser Pro Ala Tyr Phe Asp Ile Ser Asp Leu Asp Val Asn Gln Thr Ile Gln Cys Leu Glu Pro Tyr Asp Phe Ala Asp Leu Val Ala Asp Leu Gly Leu Asp Gly Leu Leu Gly Glu Asn Gly Leu Ile Ser Asn Met Ser Asn Ser Leu Asn Ser Ile Ser Glu Asn Phe Met Thr Ile Leu Phe Val Ile Gly Gly Ile Val Leu Leu Leu Phe Ile Gly Phe Met Ile Phe Arg Val Ser Met Ser Lys Lys Ser Glu Cys Thr <210> 60 <211> 2525 <212> DNA
<213> AsGV
<400> 60 atgaaccgtg cggtcgtcaa ttgggtaaga gagcgtaaca tttgtacgga taaagagaaa 60 agaattcgca accttttaat tgttaacgga ggattagaaa acacacctaa cgtcaacagt 120 ttagacacag aagagctact aatacgtgtt ttaaaaaaat taacagagga aagaatagtc 180 catcaagccg gcggaaagaa aactaccagc atcaatgtgg actatataac tctttttcct 240 aatgaacgtg aaagtttatt taatgctcga cgaggaggaa gaggtcgcgg aggtcttgga 300 agaggaggag gtaatggtaa tgatggtgat gatgcttctc aaattaaacc ggagttaaga 360 aagctacttt cgacaaaacc aaattacagc caacccaaaa gtgtgcgaga gtatatttta 420 1308 SEQ.LISTING.txt caaatggcta gagctctcgt tgaatgcgac cgaagagcgg accccgcaac cgttgaagcg 480 tctataattt ctacaaacta ccataggcgt acagatctag aaaatgcaga tctattaaac 540 gaattaaaac gatgcaagaa aaaacttaac gattgcatga tacgaaacta tactcttttg 600 agcggcggac aagagtcaca atcatcacca cctagaccgc caccttcacc acccccgccc 660 gacgatgatc gatttagggc gcaaggagag ccgtatgagt cgacacagtt gctgatagat 720 gagaataaag aattgaagag aaactattcg agattacaga gggaacttag agacatgcag 780 actcgtttga gtgaagcgga ttattctctt gaacagtgta gagatgcctt agaaaaatgc 840 gaagctaaca acatttattt acaaaacgaa cttcaagcac aatcggatct tgtcattact 900 ttacgggaca gacttgaaga gtatgaagta aaaaatcgct acaaagacga gttactcgca 960 gattgcacaa atcaattgga ccaagagcaa attcgtagaa atgagttaga aggtcgatta 1020 agaaacactg ctctcgatga atcaaactct tatgatgaac agcgtgacgt ccctaataat 1080 gctgatagat ttgtgttaga aagaagatgt agagaaacgg aagagttgcg ccaacaagaa 1140 ttagaaaaac acgaaagagc tattagtcaa gcaaaagaga gaatagatga attgcaaaaa 1200 agtttacaag attatattca acaattaaac gactgtagag aagagcttag atttagtagt 1260 agaaaaatgg aagacaccgc aagattatac aaacagcatg acaacgaaat tgaagctctc 1320 acaaccgaaa aagagcagct aatacaagac aaggcggaat tggaagaaaa acacgaaaaa 1380 tgtttaacgt taataacaca ggctagaaaa gcaatatcac aattacaaac cgaaaacgaa 1440 cagctgaagc aacgacaaaa aattaacgac gaagaagagg tcgcgacgac agaaggtggt 1500 ggtggtagcg gtaacgatga tcaatcgaat aaggtgagac aattgttgcg cgacagtcaa 1560 ataaacgcgg atattattac ttctttaaat acacaaatcg ccgcattgaa agaagccaat 1620 aaacaattag agagacaagt agatgacgtt gtggctgaaa ctagaaatac gatggaggca 1680 aatagcaaaa aacgactgga ggaagttaga aaagattttc aagaaagtat cgacgagtat 1740 gaaaacagac taaacgcatt aaaggcgaca tatgatctta atcacacaga actcggtgaa 1800 gatagctctt tatttttacc agtaaaacgg ttaatggttt cgtgtgttga agctttgagt 1860 atacagcccg agttagtaga aaatgtgtct ttacaaagga aaatttaccc acagtttgtt 1920 gatagtatta cagataattt aaatactaac gcaacaaatt tattactctt tacacagcag 1980 ataaacaacg cttacgctaa acttgtctca gataggttaa acgttcccaa tccagacatt 2040 tttaaggaca tttcagaaag aacaaaactt ttgcgagcta taaataatac tacaatcaat 2100 cgacaagaag acagtgtagt ggtcacgccg ggaccttcaa ccgttccaag cgtttcgtca 2160 cgtcctttac aaaagcccga catagcgccc aacatcacaa aagcgtttaa tagagttatg 2220 attcctcaga acgtttcaga aaatcctttt gatgtccccg aacagaacaa agtaccaagt 2280 ttacaagaag aaatagaggc ttatgattat caagaaaata taatgcgtgc caaatcgcct 2340 gtcactaaaa cttcttccac gaagcaaaaa atagaagatt attttgcaac aggaaaaagg 2400 aagagaaagt ccgctagcaa accagcgccc gttccgaaac caaaaaagac gaagaaaaaa 2460 tcaaaagtat cggaggaagg ggaggaagaa gggttaggaa gtattattaa aactgcaaaa 2520 taact 2525 <210> 61 <211> 840 <212> PRT
<213> AsGV
<400> 61 Met Asn Arg Ala Val Val Asn Trp Val Arg Glu Arg Asn Ile Cys Thr Asp Lys Glu Lys Arg Ile Arg Asn Leu Leu Ile Val Asn Gly Gly Leu Glu Asn Thr Pro Asn Val Asn Ser Leu Asp Thr Glu Glu Leu Leu Ile 1308 SEQ.LISTING.txt Arg Val Leu Lys Lys Leu Thr Glu Glu Arg Ile Val His Gln Ala Gly Gly Lys Lys Thr Thr Ser Ile Asn Val Asp Tyr Ile Thr Leu Phe Pro Asn Glu Arg Glu Ser Leu Phe Asn Ala Arg Arg Gly Gly Arg Gly Arg Gly Gly Leu Gly Arg Gly Gly Gly Asn Gly Asn Asp Gly Asp Asp Ala Ser Gln Ile Lys Pro Glu Leu Arg Lys Leu Leu Ser Thr Lys Pro Asn Tyr Ser Gln Pro Lys Ser Val Arg Glu Tyr Ile Leu Gln Met Ala Arg Ala Leu Val Glu Cys Asp Arg Arg Ala Asp Pro Ala Thr Val Glu Ala Ser Ile Ile Ser Thr Asn Tyr His Arg Arg Thr Asp Leu Glu Asn Ala Asp Leu Leu Asn Glu Leu Lys Arg Cys Lys Lys Lys Leu Asn Asp Cys Met Ile Arg Asn Tyr Thr Leu Leu Ser Gly Gly Gln Glu Ser Gln Ser Ser Pro Pro Arg Pro Pro Pro Ser Pro Pro Pro Pro Asp Asp Asp Arg Phe Arg Ala Gln Gly Glu Pro Tyr Glu Ser Thr Gln Leu Leu Ile Asp Glu Asn Lys Glu Leu Lys Arg Asn Tyr Ser Arg Leu Gln Arg Glu Leu Arg Asp Met Gln Thr Arg Leu Ser Glu Ala Asp Tyr Ser Leu Glu Gln Cys Arg Asp Ala Leu Glu Lys Cys Glu Ala Asn Asn Ile Tyr Leu Gln Asn Glu Leu Gln Ala Gln Ser Asp Leu Val Ile Thr Leu Arg Asp Arg Leu Glu Glu Tyr Glu Val Lys Asn Arg Tyr Lys Asp Glu Leu Leu Ala Asp Cys Thr Asn Gln Leu Asp Gln Glu Gln Ile Arg Arg Asn Glu Leu Glu Gly Arg Leu Arg Asn Thr Ala Leu Asp Glu Ser Asn Ser Tyr Asp Glu Gln Arg Asp Val Pro Asn Asn Ala Asp Arg Phe Val Leu Glu Arg Arg Cys Arg Glu Thr Glu Glu Leu Arg Gln Gln Glu Leu Glu Lys His Glu Arg Ala Ile Ser Gln Ala Lys Glu Arg Ile Asp Glu Leu Gln Lys Ser Leu Gln Asp Tyr Ile Gln Gln Leu Asn Asp Cys Arg Glu Glu Leu Arg Phe Ser Ser Arg Lys Met Glu Asp Thr Ala Arg Leu Tyr Lys Gln 1308 SEQ.LISTING.txt His Asp Asn Glu Ile Glu Ala Leu Thr Thr Glu Lys Glu Gln Leu Ile Gln Asp Lys Ala Glu Leu Glu Glu Lys His Glu Lys Cys Leu Thr Leu Ile Thr Gln Ala Arg Lys Ala Ile Ser Gln Leu Gln Thr Glu Asn Glu Gln Leu Lys Gln Arg Gln Lys Ile Asn Asp Glu Glu Glu Val Ala Thr Thr Glu Gly Gly Gly Gly Ser Gly Asn Asp Asp Gln Ser Asn Lys Val Arg Gln Leu Leu Arg Asp Ser Gln Ile Asn Ala Asp Ile Ile Thr Ser Leu Asn Thr Gln Ile Ala Ala Leu Lys Glu Ala Asn Lys Gln Leu Glu Arg Gln Val Asp Asp Val Val Ala Glu Thr Arg Asn Thr Met Glu Ala Asn Ser Lys Lys Arg Leu Glu Glu Val Arg Lys Asp Phe Gln Glu Ser Ile Asp Glu Tyr Glu Asn Arg Leu Asn Ala Leu Lys Ala Thr Tyr Asp Leu Asn His Thr Glu Leu Gly Glu Asp Ser Ser Leu Phe Leu Pro Val Lys Arg Leu Met Val Ser Cys Val Glu Ala Leu Ser Ile Gln Pro Glu Leu Val Glu Asn Val Ser Leu Gln Arg Lys Ile Tyr Pro Gln Phe Val Asp Ser Ile Thr Asp Asn Leu Asn Thr Asn Ala Thr Asn Leu Leu Leu Phe Thr Gln Gln Ile Asn Asn Ala Tyr Ala Lys Leu Val Ser Asp Arg Leu Asn Val Pro Asn Pro Asp Ile Phe Lys Asp Ile Ser Thr Lys Leu Leu Arg Ala Ile Asn Asn Thr Thr Ile Asn Arg Gln Glu Asp Ser Val Val Val Thr Pro Gly Pro Ser Thr Val Pro Ser Val Ser Ser Arg Pro Leu Gln Lys Pro Asp Ile Ala Pro Asn Ile Thr Lys Ala Phe Asn Arg Val Met Ile Pro Gln Asn Val Ser Glu Asn Pro Phe Asp Val Pro Glu Gln Asn Lys Val Pro Ser Leu Gln Glu Glu Ile Glu Ala Tyr Asp Tyr Gln Glu Asn Ile Met Arg Ala Lys Ser Pro Val Thr Lys Thr Ser Ser Thr Lys Gln Lys Ile Glu Asp Tyr Phe Ala Thr Gly Lys Arg Lys Arg Lys Ser Ala Ser Lys Pro Ala Pro Val Pro Lys Pro Lys Lys Thr Lys 1308 SEQ.LISTING.txt Lys Lys Ser Lys Val Ser Glu Glu Gly Glu Glu Glu Gly Leu Gly Ser Ile Ile Lys Thr Ala Lys Cys Thr <210> 62 <211> 723 <212> DNA
<213> AsGV
<400> 62 ttgcatataa aagaaccatc gaacgaggta acatcacaca acgactctac aatcgtttac 60 ctgcattatt actattcaac atgaaatact ttgccatcga cggtgtagcc gctacaacca 120 agaccaccat tttaaagcaa ttggaaggaa aattttgtgt acatctcaca gactacaaag 180 agatacggga acaattgcaa ttgaccgaaa gtaaagtttt gagtgaattt gtatatttac 240 tatatcgttt gtgcgatgaa gtgaagaccg ggtcgggaag acacattttt gatcggcaac 300 ctgtagctgc tatcttatat cagcttatac atttaaacgc tcccgacagt gtagtgttcc 360 gatacgcccg cctcatcaaa tacaacaatt ggaacaagaa ttggttttct ctcataatat 420 tgacgaagga gggtcaagag gaaaatgtag tcgaaactat ggtggaacga gacaacggga 480 tcgattgggc ggctaaagag tatgttttac gccagaatcg tgtctttaag atatgggccg 540 acgttatgga gtatccagtg tattattttg attacaagaa agactttaat aagcagcaga 600 aggaaatcat tttgattgta aaaaatttaa tgaacgacta ttttcctttg ccgtggtaca 660 aaaaaattat taacacgttc acaaagaacg ttacaggaaa gcgtgttttt ttgtaaaatg 720 act 723 <210> 63 <211> 29 <212> PRT
<213> AsGV
<400> 63 Leu His Ile Lys Glu Pro Ser Asn Glu Val Thr Ser His Asn Asp Ser Thr Ile Val Tyr Leu His Tyr Tyr Tyr Ser Thr Cys Thr <210> 64 <211> 260 <212> DNA
<213> AsGV
<400> 64 atgtcgatta taactcccgt aatagcgctc gtggttttgg ccttcctatt aaatacagcc 60 tttagaggca gtgaattaat tataacgatt ttagtccttt tggtattgtt cttttgcgtg 120 ctacatattc attatgtaaa taatgagtcg ggtccagaca ctttatttaa tgagcaaacg 180 1308 SEQ.LISTING.txt aaaaagttaa agaaaaagca gcagataaat gacgcttttg acgctatatt aaacaaaaac 240 aattcttcat tagaataact 260 <210> 65 <211> 87 <212> PRT
<213> AsGV
<400> 65 Met Ser Ile Ile Thr Pro Val Ile Ala Leu Val Val Leu Ala Phe Leu Leu Asn Thr Ala Phe Arg Gly Ser Glu Leu Ile Ile Thr Ile Leu Val Leu Leu Val Leu Phe Phe Cys Val Leu His Ile His Tyr Val Asn Asn Glu Ser Gly Pro Asp Thr Leu Phe Asn Glu Gln Thr Lys Lys Leu Lys Lys Lys Gln Gln Ile Asn Asp Ala Phe Asp Ala Ile Leu Asn Lys Asn Asn Ser Ser Leu Glu Cys Thr <210> 66 <211> 1151 <212> DNA
<213> AsGV
<400> 66 atgtggtggc ctttgtttgc agcgatcata attgcgttat tgtatttgct atatcgaccg 60 cttcaactag gccatcatgc catcagacaa cacgctttct ttcgcgaaga gatactaaac 120 gatgaggatt tgagagaaac ggtgagacga agaagatacg cgcctctaca tacccttcct 180 aatgtaaagt gggacacaaa ctttaataca ttggaaggtt cgaataaatg ttttaacacc 240 ccaactttgg taacggtgga taaaatagat aactataatt gtgcagaaat ttgcgacaac 300 gagagagcgg tttacttttt tgtcgaacct cacgatcgat acgtcgtaga cggacaaatg 360 cttattagcg gaggttattg tactacaaac tctcttccgc gtcgttgtaa cgcccagaca 420 tctttaatat tacaaagtgc caaccagtgg tcttgcattg cagaagatcc acgcttcttt 480 gcaggtgcaa acaattcaat acaacaagct ggtagacaac acattaatat gataccctcc 540 tatcaaatcg aacatttaac attgtgggat aacgagctaa atcgaattgt taatccgttt 600 gttaacaact ttagacgcac ttgggacgat ttgatgcagg atggaagacg aagatttgaa 660 gtaaaatgta acgcgcttga tgtcaattat aatcaaacat ttaacaatcc gttaaatccc 720 atagagtgtt tacccaacgt ttgtagtgac gttagatata ttcacagaga cgtgcatccc 780 gattttgaat tcggcttgtg tgattgtgga gattacgaaa ggacccgcgt caggaacctt 840 gattttaatc ctacatcgaa atgcgcttca atagttgaca ttacggccac ccaagaacaa 900 actcacaatt ttgaaaataa catatcacaa tttagagtcg aatgtatgtc gttagacacc 960 cccattacac tttactcccc cgacaaacca ttgtgtcctc cggaaatttt taattccaac 1020 accgactttg cttacacatt tttattgaga ggaactcgag gtttgagtca aaatggaatg 1080 gaagagccca cttttcgttt atggaccgat acaaaaacta gaatcaattg gacaggttat 1140 gtcactaaaa cttc 1308 SEQ.LISTING.txt ggtgcttaac t 1151 <210> 67 <211> 382 <212> PRT
<213> AsGV
<400> 67 Met Trp Trp Pro Leu Phe Ala Ala Ile Ile Ile Ala Leu Leu Tyr Leu Leu Tyr Arg Pro Leu Gln Leu Gly His His Ala Ile Arg Gln His Ala Phe Phe Arg Glu Glu Ile Leu Asn Asp Glu Asp Leu Arg Glu Thr Val Arg Arg Arg Arg Tyr Ala Pro Leu His Thr Leu Pro Asn Val Lys Trp Asp Thr Asn Phe Asn Thr Leu Glu Gly Ser Asn Lys Cys Phe Asn Thr Pro Thr Leu Val Thr Val Asp Lys Ile Asp Asn Tyr Asn Cys Ala Glu Ile Cys Asp Asn Glu Arg Ala Val Tyr Phe Phe Val Glu Pro His Asp Arg Tyr Val Val Asp Gly Gln Met Leu Ile Ser Gly Gly Tyr Cys Thr Thr Asn Ser Leu Pro Arg Arg Cys Asn Ala Gln Thr Ser Leu Ile Leu Gln Ser Ala Asn Gln Trp Ser Cys Ile Ala Glu Asp Pro Arg Phe Phe Ala Gly Ala Asn Asn Ser Ile Gln Gln Ala Gly Arg Gln His Ile Asn Met Ile Pro Ser Tyr Gln Ile Glu His Leu Thr Leu Trp Asp Asn Glu Leu Asn Arg Ile Val Asn Pro Phe Val Asn Asn Phe Arg Arg Thr Trp Asp Asp Leu Met Gln Asp Gly Arg Arg Arg Phe Glu Val Lys Cys Asn Ala Leu Asp Val Asn Tyr Asn Gln Thr Phe Asn Asn Pro Leu Asn Pro Ile Glu Cys Leu Pro Asn Val Cys Ser Asp Val Arg Tyr Ile His Arg Asp Val His Pro Asp Phe Glu Phe Gly Leu Cys Asp Cys Gly Asp Tyr Glu Arg Thr Arg Val Arg Asn Leu Asp Phe Asn Pro Thr Ser Lys Cys Ala Ser Ile Val Asp Ile Thr Ala Thr Gln Glu Gln Thr His Asn Phe Glu Asn Asn Ile Ser Gln Phe Arg Val Glu Cys Met Ser Leu Asp Thr 1308 SEQ.LISTING.txt Pro Ile Thr Lys Pro Asp Lys Pro Leu Cys Pro Pro Glu Ile Phe Asn Ser Asn Thr Asp Phe Ala Tyr Thr Phe Leu Leu Arg Gly Thr Arg Gly Leu Ser Gln Asn Gly Met Glu Glu Pro Thr Phe Arg Leu Trp Thr Asp Thr Lys Thr Arg Ile Asn Trp Thr Gly Tyr Gly Ala Cys Thr <210> 68 <211> 762 <212> DNA
<213> AsGV
<400> 68 atgaacattt ctaattttct tctgaacaac tcctttttaa acatcaataa tgaaatttgt 60 gaaaaataca aactgaagta caaacacgac ctggacacta attttattca acaccaactc 120 tcgcctcaca atttaatagt tttacgcaat acaataaaaa ttattctctc attacaagaa 180 cactatcccc acacaatgtt tatatttgaa agcgtagtct tcacaataca attaaaactc 240 tatcaatact cgctaatttt aaaagattta gacgacgagc ttgtcggatg tgatgtcgac 300 ttagaccatt tgagaagttt taaaactttt ctcgaggcgg gtgtcgacat caactttgag 360 acgattgatt acgaatatat tactttatat cgcgatatag ttgtagagtg tttagaagag 420 agcgctcgcg tagttcgtag aatattctta gataaagatg aagcgtatcg attttataaa 480 gtaagcgtga atcatagtaa attgtgcggt gtatgtaaag aagagaggtg tgatactttt 540 aaaacggagt gtggacacga tttttgctac gagtgtttta taaagtgcat tagtgaaaac 600 aattcgtgtc ctttatgtcg tagcgtaaaa ggttttaaat atgtaagtgg agaaaagaaa 660 gacgtgttaa ataaaataaa aaccacccac aatgattaca aattgtcttg gtcgagcgaa 720 cggtgaatat atacgtaaga gatggactcc gagttactca ct 762 <210> 69 <211> 241 <212> PRT
<213> AsGV
<400> 69 Met Asn Ile Ser Asn Phe Leu Leu Asn Asn Ser Phe Leu Asn Ile Asn Asn Glu Ile Cys Glu Lys Tyr Lys Leu Lys Tyr Lys His Asp Leu Asp Thr Asn Phe Ile Gln His Gln Leu Ser Pro His Asn Leu Ile Val Leu Arg Asn Thr Ile Lys Ile Ile Leu Ser Leu Gln Glu His Tyr Pro His Thr Met Phe Ile Phe Glu Ser Val Val Phe Thr Ile Gln Leu Lys Leu Tyr Gln Tyr Ser Leu Ile Leu Lys Asp Leu Asp Asp Glu Leu Val Gly 1308 SEQ.LISTING.txt Cys Asp Val Asp Leu Asp His Leu Arg Ser Phe Lys Thr Phe Leu Glu Ala Gly Val Asp Ile Asn Phe Glu Thr Ile Asp Tyr Glu Tyr Ile Thr Leu Tyr Arg Asp Ile Val Val Glu Cys Leu Glu Glu Ser Ala Arg Val Val Arg Arg Ile Phe Leu Asp Lys Asp Glu Ala Tyr Arg Phe Tyr Lys Val Ser Val Asn His Ser Lys Leu Cys Gly Val Cys Lys Glu Glu Arg Cys Asp Thr Phe Lys Thr Glu Cys Gly His Asp Phe Cys Tyr Glu Cys Phe Ile Lys Cys Ile Ser Glu Asn Asn Ser Cys Pro Leu Cys Arg Ser Val Lys Gly Phe Lys Tyr Val Ser Gly Glu Lys Lys Asp Val Leu Asn Lys Ile Lys Thr Thr His Asn Asp Tyr Lys Leu Ser Trp Ser Ser Cys Thr <210> 70 <211> 1151 <212> DNA
<213> AsGV
<400> 70 atgaatacat ctacggaaga gtcgagtact aatagtatta gaaatattaa taattataac 60 atttggcgta tagtgattaa gcaagatcca atttttccgc gagttttaga agaaacaata 120 gaaagacaaa agcgcggtga cgatgtagtg cctaggggtg aaggaaagca taaaaattta 180 tggcagcctc ataaaaaatc gcaagagtat aaacaaacaa ccaaagatga gttccaatcg 240 ctgttattaa aaattatata ttgtttgatc gaagaggaag atctggaaaa ttatggttgg 300 tacaccgttg aaagagagtt agggagtttg cttaaagcgg aaccgctaat ggatgtagag 360 gattttattg aaaggttgct tattatgggt aatgtgtcga agaaaagatt acaggccaca 420 ataaattttt atacaagatc aatgaagatt cccgactact atataccgag taatgttgaa 480 ttgccaaaag atagggagaa gaaagatcgc ttagcaataa ataaaacaat tgttttaaaa 540 gacgatttta ttgatccgat aagtgatttt attgacaaag aaatacaata taaaaattat 600 tacaacaatc aaagtttgct tcgtgcagca atagctttta acattattaa aggtacgggt 660 ttaagaataa caaatgctta tcaaataaaa ttggtagatt tagaaaaaat tttgcaaaag 720 ggtgaacata aagtaatgaa tcttattact aaacatggta aggtgaattt ttgttatgtc 780 acttgtaaaa ataaaaaagc tctttgcacc gccatagagc tatacaaaaa agtcccagag 840 gatctcctaa acaaaatatc atctaaaagc ccaactcgct tcaaagactt tcgtatgtta 900 gtcgacaccg tttttgtgga tcgggacaca aattttaaat ctaacatgat tcgaaactat 960 gttgcagaca ctatactgaa cagcggtctt tctttaaata aaacttcaaa gcttatgaat 1020 cacaggtccg tgactgcaac aaagcattac attaacaagt ttcaccccgg tccgacgctt 1080 gtaaatgacg agtctagcaa cgatggtgct gaaggaaatg atgaaagggg tctaattgat 1140 tttaattaac t 1151 1308 SEQ.LISTING.txt <210> 71 <211> 384 <212> PRT
<213> AsGV
<400> 71 Met Asn Thr Ser Thr Glu Glu Ser Ser Thr Asn Ser Ile Arg Asn Ile Asn Asn Tyr Asn Ile Trp Arg Ile Val Ile Lys Gln Asp Pro Ile Phe Pro Arg Val Leu Glu Glu Thr Ile Glu Arg Gln Lys Arg Gly Asp Asp Val Val Pro Arg Gly Glu Gly Lys His Lys Asn Leu Trp Gln Pro His Lys Lys Ser Gln Glu Tyr Lys Gln Thr Thr Lys Asp Glu Phe Gln Ser Leu Leu Leu Lys Ile Ile Tyr Cys Leu Ile Glu Glu Glu Asp Leu Glu Asn Tyr Gly Trp Tyr Thr Val Glu Arg Glu Leu Gly Ser Leu Leu Lys Ala Glu Pro Leu Met Asp Val Glu Asp Phe Ile Glu Arg Leu Leu Ile Met Gly Asn Val Ser Lys Lys Arg Leu Gln Ala Thr Ile Asn Phe Tyr Thr Arg Ser Met Lys Ile Pro Asp Tyr Tyr Ile Pro Ser Asn Val Glu Leu Pro Lys Asp Arg Glu Lys Lys Asp Arg Leu Ala Ile Asn Lys Thr Ile Val Leu Lys Asp Asp Phe Ile Asp Pro Ile Ser Asp Phe Ile Asp Lys Glu Ile Gln Tyr Lys Asn Tyr Tyr Asn Asn Gln Ser Leu Leu Arg Ala Ala Ile Ala Phe Asn Ile Ile Lys Gly Thr Gly Leu Arg Ile Thr Asn Ala Tyr Gln Ile Lys Leu Val Asp Leu Glu Lys Ile Leu Gln Lys Gly Glu His Lys Val Met Asn Leu Ile Thr Lys His Gly Lys Val Asn Phe Cys Tyr Val Thr Cys Lys Asn Lys Lys Ala Leu Cys Thr Ala Ile Glu Leu Tyr Lys Lys Val Pro Glu Asp Leu Leu Asn Lys Ile Ser Ser Lys Ser Pro Thr Arg Phe Lys Asp Phe Arg Met Leu Val Asp Thr Val Phe Val Asp Arg Asp Thr Asn Phe Lys Ser Asn Met Ile Arg Asn Tyr Val Ala Asp Thr Ile Leu Asn Ser Gly Leu Ser Leu Asn Lys Thr Ser 1308 SEQ.LISTING.txt Lys Leu Met Asn His Arg Ser Val Thr Ala Thr Lys His Tyr Ile Asn Lys Phe His Pro Gly Pro Thr Leu Val Asn Asp Glu Ser Ser Asn Asp Gly Ala Glu Gly Asn Asp Glu Arg Gly Leu Ile Asp Phe Asn Cys Thr <210> 72 <211> 800 <212> DNA
<213> AsGV
<400> 72 atgaaatgcg cctacgtgac tttaatcatg ctcggtgata aatatgtacc tggtgcagta 60 gccttggcta acagtttatc tagctccggt tcttatcatg atagggtttg cctcgtgacc 120 aaagacgtta cattgatagc agaattggag cgggtgttcg ataaagtcat acaagtagaa 180 tttattcatt acaaatgcgg caatatgtta acctcgagac aagaggaatt gtattcgtcc 240 tggatagatt attctttcac caaatggcgt tgtttggaac ttacacagta ttcaaagtgt 300 gtatatcttg acgctgatca aatagtgctt aaaaatattg atcacctgtt taatttgatc 360 acaccagcaa tgtgctttaa tcataattac aatgaaacct ttaaaaaata caagtatgga 420 aaacaaatag tttgcttaaa ggaaatattc gacaacagca ccgttttagg ttttaccggc 480 acgttcgttt acgcaccttg cgttaaatta tttcaacaaa taaaagcttt actaacacca 540 aacaacaggt gtttattaca aaacaaatac aataatggat ttgaggaagt cgtcttagct 600 caggccatga tagccttgaa aatcataccg acgcagctgt ctccaatgta tttgtggaac 660 gcgggtgatt atatgattat taaaagaagc caaccgtatg ttatcaatta ttacggagag 720 aaaaagcctt ggtgtggcga cataaaattt atggatgagt acatttggtg gtggttttat 780 aaatataata agatataact 800 <210> 73 <211> 263 <212> PRT
<213> AsGV
<400> 73 Met Lys Cys Ala Tyr Val Thr Leu Ile Met Leu Gly Asp Lys Tyr Val Pro Gly Ala Val Ala Asn Ser Leu Ser Ser Ser Gly Ser Tyr His Asp Arg Val Cys Leu Val Thr Lys Asp Val Thr Leu Ile Ala Glu Leu Glu Arg Val Phe Asp Lys Val Ile Gln Val Glu Phe Ile His Tyr Lys Cys Gly Asn Met Leu Thr Ser Arg Gln Glu Glu Lys Ser Trp Ile Asp Tyr Ser Phe Thr Lys Trp Arg Cys Leu Glu Leu Thr Gln Tyr Ser Lys Cys 1308 SEQ.LISTING.txt Val Tyr Leu Asp Ala Asp Gln Ile Val Leu Lys Asn Ile Asp His Leu Phe Asn Leu Ile Thr Pro Ala Met Cys Phe Asn His Asn Tyr Asn Glu Thr Phe Lys Lys Tyr Lys Tyr Gly Lys Gln Ile Val Cys Leu Lys Glu Ile Phe Asp Asn Ser Thr Val Leu Gly Phe Thr Gly Thr Phe Val Tyr Ala Pro Cys Val Lys Leu Phe Gln Gln Ile Lys Ala Leu Leu Thr Pro Asn Asn Arg Cys Leu Leu Gln Asn Lys Tyr Asn Asn Gly Phe Glu Glu Val Val Leu Ala Gln Ala Met Ile Ala Leu Lys Ile Ile Pro Thr Gln Leu Ser Pro Met Tyr Leu Trp Asn Ala Gly Asp Tyr Met Ile Ile Lys Arg Ser Gln Pro Tyr Val Ile Asn Tyr Tyr Gly Glu Lys Lys Pro Trp Cys Gly Asp Ile Lys Phe Met Asp Glu Tyr Ile Trp Trp Trp Phe Tyr Lys Tyr Asn Lys Ile Cys Thr <210> 74 <211> 869 <212> DNA
<213> AsGV
<400> 74 atgatggatt ctgcaatgga aactataact acagttgcca ttctcgacaa cgacgattgg 60 caggcaaagt tcatcaacaa gctgaatgag aacactaacg cagtacgaac attggaatgc 120 agcaaccgct tcagtcttca caacgcgttg ttgtctttta aaaaaatggc gccaatcaaa 180 agtttggagc tgaaacgaga ccctgttacc ggagacctaa taataccgga aaaagtgaag 240 atggacaaga tagagcgtaa gaacaagata tgctatacga taggcctgag tcgtttagga 300 ggtgtgaata aatgctatta ttgggaccat tgcattgcca agatatgcaa gagcgctacg 360 gcaggaaagt ttcttgtggt tactggaaaa tttgagccgg tattaatgga cgttgtagaa 420 gagatgatgg gaaagtactt taaaagaaca aaaaagcagc aaaccgacga gcctataata 480 ttatccggca ccgcggtcac ccatgtaccg tctatgggtg aagtggacaa atggcgtcaa 540 ttcttgcaaa agttttttgt actagccaac agagataact ctgcaaacat tgcaagcaat 600 gaagtgaaag aaaattgtat gctgcatccc atgagtgaga atttctttag atacgtcttt 660 ggttcgttgg aggatagaaa cgttggaaat caagttgaat gcaccgtcgg tttggtgttt 720 agcagtgtcg aagagatgct tgcaaagaga actgtgagtt ctttatcgac aaccgaagag 780 gttaaagaaa gcgcttttac tcttagattg gaacccgcca ttgttatata tcacgataga 840 ctcgatgagt atgtgaagtt caaatgact 869 <210> 75 <211> 286 <212> PRT
<213> AsGV
1308 SEQ.LISTING.txt <400> 75 Met Met Asp Ser Ala Met Ile Thr Thr Val Ala Ile Leu Asp Asn Asp Asp Trp Gln Ala Lys Phe Ile Asn Lys Leu Asn Glu Asn Thr Asn Ala Val Arg Thr Leu Glu Cys Ser Asn Arg Phe Ser Leu His Asn Ala Leu Leu Ser Phe Lys Lys Met Ala Pro Ile Lys Ser Leu Glu Leu Lys Arg Asp Pro Val Thr Gly Asp Leu Ile Ile Pro Glu Lys Val Lys Met Asp Lys Ile Glu Arg Lys Asn Lys Ile Cys Tyr Thr Ile Gly Leu Ser Arg Leu Gly Gly Val Asn Lys Cys Tyr Tyr Trp Asp His Cys Ile Ala Lys Ile Cys Lys Ser Ala Thr Ala Gly Lys Phe Leu Val Val Thr Gly Lys Phe Glu Pro Val Leu Met Asp Val Val Glu Glu Met Met Gly Lys Tyr Phe Lys Arg Thr Lys Lys Gln Gln Thr Asp Glu Pro Ile Ile Leu Ser Gly Thr Ala Val Thr His Val Pro Ser Met Gly Glu Val Asp Lys Trp 165 170 175 ' Arg Gln Phe Leu Gln Lys Phe Phe Val Leu Ala Asn Arg Asp Asn Ser Ala Asn Ile Asn Glu Val Lys Glu Asn Cys Met Leu His Pro Met Ser Glu Asn Phe Phe Arg Tyr Val Phe Gly Ser Leu Glu Asp Arg Asn Val Gly Asn Gln Val Glu Cys Thr Val Gly Leu Val Phe Ser Ser Val Glu Glu Met Leu Ala Lys Arg Thr Val Ser Ser Leu Ser Thr Thr Glu Glu Val Lys Glu Ser Ala Phe Thr Leu Arg Leu Glu Pro Ala Ile Val Ile Tyr His Asp Arg Leu Asp Glu Tyr Val Lys Phe Lys Cys Thr <210> 76 <211> 932 <212> DNA
<213> AsGV
<400> 76 1308 SEQ.LISTING.txt atggatacaa gacgaggtat ggatacaaca gggggtagtg atgtttcaca agccggtaat 60 aattttatta actggaacac cactgccgct atgatcaata tgtaccgctc caataacaca 120 gctaaattaa cacccgaaca aattgcatgt ttaaatttgg ttagagattt gtttcttcaa 180 gccgaacccc taccggtgag cgtcactaaa aggtttgaaa cagatgagga gctaattaat 240 tactataaaa atttggaaaa aaaatatgga ggtgcaacgc agttaagcgg cggtactcat 300 ggaatttttg ataaaagctt tgtcatctca cctataatga aagcgtatgc ggataagttt 360 tataaaagac gcctcaatgt ggctgcatca catttaagcg atgttgtaaa gtatcaaatg 420 gcaaacgccg ttacccacag taaacctctt cctattgtac acaacgatgt ggctgatgaa 480 tatttaaata cgctcaaaca cagaagtcct attgcgccaa acgtggaaaa gctcgttgct 540 gatagatcta atcaacggct taacgtgtgc aacgacgtgt ttaataattt agtagaagat 600 gtgctattcg gaagtcataa cggatatttt attaactcta tactaaaaaa tgacttaaag 660 ggaaaggtgt acaaatttcg agacaatatc gcttacttgg ttaacgcacc tctcacgcta 720 tcgacaaatg tatacatgtt aatagaaaaa gctgcaatca acgctggtca tcatgcggcc 780 gacgaaaaaa tgtacgagga gatcgtctct aatactgctc atcgaacaac ccctatacaa 840 gagagtttga ccgaactggc gtttgaaaac gaagcgctcc ggcgcggttt gatacaagac 900 ctcaacatta aatataaaaa tttgtcatag ct 932 <210> 77 <211> 311 <212 > PRT
<213> AsGV
<400> 77 Met Asp Thr Arg Arg Gly Met Asp Thr Thr Gly Gly Ser Asp Val Ser Gln Ala Gly Asn Asn Phe Ile Asn Trp Asn Thr Thr Ala Ala Met Ile Asn Met Tyr Arg Ser Asn Asn Thr Ala Lys Leu Thr Pro Glu Gln Ile Ala Cys Leu Asn Leu Val Arg Asp Leu Phe Leu Gln Ala Glu Pro Leu Pro Val Ser Val Thr Lys Arg Phe Glu Thr Asp Glu Glu Leu Ile Asn Tyr Tyr Lys Asn Leu Glu Lys Lys Tyr Gly Gly Ala Thr Gln Leu Ser Gly Gly Thr His Gly Ile Phe Asp Lys Ser Phe Val Ile Ser Pro Ile Met Lys Ala Tyr Ala Asp Lys Phe Tyr Lys Arg Arg Leu Asn Val Ala Ala Ser His Leu Ser Asp Val Val Lys Tyr Gln Met Ala Asn Ala Val Thr His Ser Lys Pro Leu Pro Ile Val His Asn Asp Val Ala Asp Glu Tyr Leu Asn Thr Leu Lys His Arg Ser Pro Ile Ala Pro Asn Val Glu Lys Leu Val Ala Asp Arg Ser Asn Gln Arg Leu Asn Val Cys Asn Asp Val Phe Asn Asn Leu Val Glu Asp Val Leu Phe Gly Ser His Asn Gly SEQ.LISTING.txt TyrPhe Ile Asn Ser Ile Leu Lys Asn Asp Leu Lys Gly Lys Val Tyr LysPhe Arg Asp Asn Ile Ala Tyr Leu Val Asn Ala Pro Leu Thr Leu SerThr Asn Val Tyr Met Leu Ile Glu Lys Ala Ala Ile Asn Ala Gly HisHis Ala Ala Asp Glu Lys Met Tyr Glu Glu Ile Val Ser Asn Thr AlaHis Arg Thr Thr Pro Ile Gln Glu Ser Leu Thr Glu Leu Ala Phe GluAsn Glu Ala Leu Arg Arg Gly Leu Ile Gln Asp Leu Asn Ile Lys TyrLys Asn Leu Ser Cys Thr <210> 78 <211> 1184 <212> DNA
<213> AsGV
<400> 78 atgggacttc atactaaact gagcaaacgc attcatgacg gaaacgaatc attgctggtg 60 acaagagttg aaatcattac aagtgtgatt aaatttatcg tcactttact ttttatcgtg 120 accaacaagg aggagaatca gctgaaatat aaaattcgac ttgtccttct tcccgtctgc 180 ggttctgtgt taacgctgat cacgctactc tatatggatt cgtatcaaga cacgatcacc 240 acgtcttgga tttacttttt atccatcctt ccgtctctta ccggagaatc ttttttgctg 300 gaaacgtgct tgtcggacgt cgttgcccta atagaaaagt gtcccaaaag aagggtgaca 360 ttatatttgt gggtgaaagg aggaaaaatg attggagtgt gcttaataca agtagtagca 420 cctcttgttg gaatcacaga attttatatg ataaatatgg tctctccttt cgtgtgtgtc 480 gttttggtga tgacaacatt tatggctatt tgcttggaaa ccaaaccggc cccctcgcct 540 gaagaaatcg atttgaccgc accaaaaccg cttaacacca ccgctcaacg cccctcgctg 600 tataacacgc ttcgagaaat gacaaagtac cattatttgt tatgtctttt gataacacta 660 catagtgcgc aacgaggcga gtacaagttt acattcatat ttctcagctc acatttggat 720 tttgcaccta aggaactgag actgatcaac ggagctcaat acaccctgtt cgctgtgtct 780 ttatacgtta tgggtttcat aattaaatcg gtcaaactac ccgcagttac aatgatagct 840 tttatcattt ctatgctgtt tagcacagct gccagagtat gtcaaattat tgcgtgggac 900 ctgaacagat tcaatgtttg gtgtttatct gcactcctgt ccactcctgg ccctttagcg 960 tatcaaatta tgcaacaatt aatgtaccaa aaatttgaag aaaaacgatt ggtcggtttt 1020 gtgctgctca ccgctgatca attcgtctcg attccatttg tacaattata tcaaaccgtt 1080 gcacagttgt atgtcacacc attttatgtt acactgggac tcatgattgc agttacaatt 1140 ggaggtttaa gcttcaaaac tatgagaaac tggttaaggt aact 1184 <210> 79 <211> 393 <212> PRT
<213> AsGV

1308 SEQ.LISTING.txt <400> 79 Met Gly Leu His Thr Lys Leu Ser Lys Arg Ile His Asp Gly Asn Glu Ser Leu Leu Val Thr Arg Val Glu Ile Ile Thr Ser Val Ile Lys Phe Ile Val Thr Leu Leu Phe Ile Val Thr Asn Lys Glu Glu Asn Gln Leu Lys Tyr Lys Ile Arg Leu Val Leu Leu Pro Val Cys Gly Ser Val Leu Thr Leu Ile Thr Leu Leu Tyr Met Asp Ser Tyr Gln Asp Thr Ile Thr Thr Ser Trp Ile Tyr Phe Leu Ser Ile Leu Pro Ser Leu Thr Gly Glu Ser Phe Leu Leu Glu Thr Cys Leu Ser Asp Val Val Ile Glu Lys Cys Pro Lys Arg Arg Val Thr Leu Tyr Leu Trp Val Lys Gly Gly Lys Met Ile Gly Val Cys Leu Ile Gln Val Val Ala Pro Leu Val Gly Ile Thr Glu Phe Tyr Met Ile Asn Met Val Ser Pro Phe Val Cys Val Val Leu Val Met Thr Thr Phe Met Ala Ile Cys Leu Glu Thr Lys Pro Ala Pro Ser Pro Glu Glu Ile Asp Leu Thr Ala Pro Lys Pro Leu Asn Thr Thr Ala Gln Arg Pro Ser Leu Tyr Asn Thr Leu Arg Glu Met Thr Lys Tyr His Tyr Leu Leu Cys Leu Leu Ile Thr Leu His Ser Ala Gln Arg Gly Glu Tyr Lys Phe Thr Phe Ile Phe Leu Ser Ser His Leu Asp Phe Ala Pro Lys Glu Leu Arg Leu Ile Asn Gly Ala Gln Tyr Thr Leu Phe Ala Val Ser Leu Tyr Val Met Gly Phe Ile Ile Lys Ser Val Lys Leu Pro Ala Val Thr Met Ile Ala Phe Ile Ile Ser Met Leu Phe Ser Thr Ala Ala Arg Val Cys Gln Ile Ile Ala Trp Asp Leu Asn Arg Phe Asn Val Trp Cys Leu Ser Ala Leu Leu Ser Thr Pro Gly Pro Leu Ala Tyr Gln Ile Met Gln Gln Leu Met Tyr Gln Lys Phe Glu Glu Lys Arg Leu Val Gly Phe Val Leu Leu Thr Ala Asp Gln Phe Val Ser Ile Pro Phe Val Gln Leu Tyr Gln Thr Val Ala Gln Leu Tyr Val Thr Pro Phe Tyr Val 1308 SEQ.LISTING.txt Thr Leu Gly Leu Met Ile Ala Val Thr Ile Gly Gly Leu Ser Phe Lys Thr Met Arg Asn Trp Leu Arg Cys Thr <210> 80 <211> 252 <212> DNA
<213> AsGV
<400> 80 aatgcaacac aatgttaaac tatacactgg tcacaattac atttttccct tgtggttaac 60 aaaacaactg attttatata tgggaggaga gaaatatgtt aatatgataa actggactag 120 aagtacacga tattatctta ttttaaagaa ggcatgctac tccaacataa tttcaagctt 180 acgattcttt tatccagacg gttgtgtgtt tagagttttt actgaaaacg aaattaatac 240 aaacttttaa ct 252 <210> 81 <211> 7 <212> PRT
<213> AsGV
<400> 81 Asn Ala Thr Gln Cys Cys Thr <210> 82 <211> 596 <212> DNA
<213> AsGV
<400> 82 atgtcgagtc aaaacaatag caaggaccgc gttaaatttg attctgaagt gttgttacgt 60 tatatttacg attatagttt aacggcttcc aacgaaccca atgtaatcaa aatatgcagg 120 gtaaaagtta gaaaaactgg aggagctgtg ttggctcact actacgccca agtgtttgtt 180 tctaacaaat tttcatttga atttcatcct ggaagtcaac cgaaaacttt tcaaaatgtg 240 gacacggaaa aggagcacct tcccgtttgt gtcaagttta tgtgcgacga gtgtacaaag 300 caagaattgc gcgattatat tgaaggagag aatcagttta acattgcgtt taagaattgc 360 gaatccattt tatgtaaacg taaaagcgta caaactgtaa taataacaat tttaattgta 420 gtattattaa taaatttggt caactttagc gccttaaata ttatagtaat agcattttta 480 ttaatcctcc tatacattgt aaataattat ttattatcaa aaccaaaagt ttcaatatgc 540 aaacattaca aattaaataa acgtgctaat tttattgaga aaatctgtaa ataact 596 <210> 83 <211> 197 <212> PRT

Ile Met Gln Gln Leu Met Tyr Gln Lys <213> AsGV
1308 SEQ.LISTING.txt <400> 83 Met Ser Ser Gln Asn Asn Ser Lys Asp Arg Val Lys Phe Asp Ser Glu Val Leu Leu Arg Tyr Ile Tyr Asp Tyr Ser Leu Thr Asn Glu Pro Asn Val Ile Lys Ile Cys Arg Val Lys Val Arg Lys Thr Gly Gly Ala Val Leu Ala His Tyr Tyr Ala Gln Val Phe Val Ser Asn Lys Phe Ser Phe Glu Phe His Pro Gly Ser Gln Pro Lys Thr Phe Gln Asn Val Asp Thr Glu Lys Glu His Leu Pro Val Cys Val Lys Phe Met Cys Asp Glu Cys Thr Lys Gln Glu Leu Arg Asp Tyr Ile Glu Gly Glu Asn Gln Phe Asn Ile Ala Phe Lys Asn Cys Glu Ser Ile Leu Cys Lys Arg Lys Ser Val Gln Thr Val Ile Ile Thr Ile Leu Ile Val Val Leu Leu Ile Asn Leu Val Asn Phe Ser Ala Leu Asn Ile Ile Val Ile Ala Phe Leu Leu Ile Leu Leu Tyr Ile Val Asn Asn Tyr Leu Leu Ser Lys Pro Lys Val Ser Ile Cys Lys His Tyr Lys Leu Asn Lys Arg Ala Asn Phe Ile Glu Lys Ile Cys Lys Cys Thr <210> 84 <211> 1112 <212> DNA
<213> AsGV
<400> 84 atggagcgtg taactaagtt ttttggaggc aagtttaaga gcgccctttc attaccccgt 60 ctggaggaag acctaccaga atataataat tcggaaactt tggtgttaaa aatttggcca 120 ccaacgtatg ccccctcttg gcactactac caacttcacc aagcaaatta ttggtctgca 180 acggagcatg aacccttaga agatgtcagt ggattcatta aattagattc gcagtggcaa 240 aaagctgtac tacacagttt tgccattttg gcaataggag acgacgccgt aatgcaattt 300 atcgacgaga acgatctcga gtgggaagaa tgtacgcagt ggatgttcaa agatcaaggt 360 gcaagagaaa ctatccacaa aattgtatac aacaaaatgc tgcatttggc cgatcactct 420 tccgagttta ccaccagtat gttaacaagc aagaaatata ttaattatat tttgcacaat 480 aactccgatc tgaagctgca aaagtataaa ttagaagacg aagttatgaa gaaggccgcc 540 ttcttgataa agatgatttt ttgtgaacgc tatttattcg caacaccatt tctcgtgatc 600 aatctgatgg gggagagcgg gtttcttaac aattgtgttc gcattaatat gcaagttatg 660 1308 SEQ.LISTING.txt aaagatgaac acgtacacta tttgcacgcc gtccaacttt ttcgtgatct aaagccaaaa 720 agtgaccaaa ttgatgaaat taacaagtta tttttcgata tggctcagga gtttgttgaa 780 atcgtggaaa atatgatcat gaagattgga gcgggactag agtctaaata taaacaaggt 840 tttttggacc actcccgttt tactctacac accatctact ccgattgtgg aatagatgtg 900 ccgcaaagtt tagcagagta tacaaccaca ccgtttattg tgtttgataa aaatactgga 960 gccgacaagt ttaatttaat ggagtcaaat tcgacagtct ataaagcggt tcgcgcacaa 1020 tacgtgccag actggaacaa tttacaagac gaggaagctg ataaagaaat tgttgttgag 1080 tgcaaattaa aaaagcgtaa acgcgattaa ct 1112 <210> 85 <211> 371 <212> PRT
<213> AsGV
<400> 85 Met Glu Arg Val Thr Lys Phe Phe Gly Gly Lys Phe Lys Ser Ala Leu Ser Leu Pro Arg Leu Glu Glu Asp Leu Pro Glu Tyr Asn Asn Ser Glu Thr Leu Val Leu Lys Ile Trp Pro Pro Thr Tyr Ala Pro Ser Trp His Tyr Tyr Gln Leu His Gln Ala Asn Tyr Trp Ser Ala Thr Glu His Glu Pro Leu Glu Asp Val Ser Gly Phe Ile Lys Leu Asp Ser Gln Trp Gln Lys Ala Val Leu His Ser Phe Ala Ile Leu Ala Ile Gly Asp Asp Ala Val Met Gln Phe Ile Asp Glu Asn Asp Leu Glu Trp Glu Glu Cys Thr Gln Trp Met Phe Lys Asp Gln Gly Ala Arg Glu Thr Ile His Lys Ile Val Tyr Asn Lys Met Leu His Leu Ala Asp His Ser Ser Glu Phe Thr Thr Ser Met Leu Thr Ser Lys Lys Tyr Ile Asn Tyr Ile Leu His Asn Asn Ser Asp Leu Lys Leu Gln Lys Tyr Lys Leu Glu Asp Glu Val Met Lys Lys Ala Ala Phe Leu Ile Lys Met Ile Phe Cys Glu Arg Tyr Leu Phe Ala Thr Pro Phe Leu Val Ile Asn Leu Met Gly Glu Ser Gly Phe Leu Asn Asn Cys Val Arg Ile Asn Met Gln Val Met Lys Asp Glu His Val His Tyr Leu His Ala Val Gln Leu Phe Arg Asp Leu Lys Pro Lys Ser Asp Gln Ile Asp Glu Ile Asn Lys Leu Phe Phe Asp Met Ala Gln Glu Phe Val Glu Ile Val Glu Asn Met Ile Met Lys Ile Gly Ala Gly 1308 SEQ.LISTING.txt Leu Glu Ser Lys Tyr Lys Gln Gly Phe Leu Asp His Ser Arg Phe Thr Leu His Thr Ile Tyr Ser Asp Cys Gly Ile Asp Val Pro Gln Ser Leu Ala Glu Tyr Thr Thr Thr Pro Phe Ile Val Phe Asp Lys Asn Thr Gly Ala Asp Lys Phe Asn Leu Met Glu Ser Asn Ser Thr Val Tyr Lys Ala Val Arg Ala Gln Tyr Val Pro Asp Trp Asn Asn Leu Gln Asp Glu Glu Ala Asp Lys Glu Ile Val Val Glu Cys Lys Leu Lys Lys Arg Lys Arg Asp Cys Thr <210> 86 <211> 716 <212> DNA
<213> AsGV
<400> 86 aataaatcgc tgttgtaatg aaatttttta ttaaatatga ttattcctat ttctcttctt 60 tttctttcgt cgatttttac gaccgcacaa tgcgcaacct ctcttctaaa aaccactgcc 120 ggtaaatatt tttgtgttca aggatcaaat gtagtagtta gcactaaaac agacaaaaca 180 tgttatttag cacatttttc gatacatgct catgaaggtg gtttagtttt aaattttaaa 240 tatgaatccg cttgtaaata catgtgtatt aataggtgcg gggaattgta ttacgacgag 300 atgtatcata ttgaagattg taaatttact actatggctt ttaaagagtt tgattctctc 360 tctgtgaacc gaggaaacta ttctgatttt attgcttttg cagattacaa cgcgctcttg 420 tatagtttaa aagatggcga tgtattgggt aggggtgaaa catatttgaa aatgtctctt 480 gaaaaaagcg gcggtgccga gtgtatattg ggtaatgttg ataagaacac taaaataaca 540 aaaaagtgta ttgtaaaaca aaacttcgac tcaacccctt ttgatcggca ttcaaattat 600 aatttttctt tatgggaaaa gtttttgatc atgatcaatt ggttcaggat agaagagcca 660 aagagcgacg gtttaagaaa aattgactat aataaaaatt ataatgcaga ataact 716 <210> 87 <211> 7 <212> PRT
<213> AsGV
<400> 87 Asn Lys Ser Leu Leu Cys Thr <210> 88 <211> 536 <212> DNA
<213> AsGV
1308 SEQ.LISTING.txt <400> 88 atggcaacaa caagcgtgga tagagatagc attataatat atcctgtatt agaggaagaa 60 caaataatgt ttaaagtgaa agaggattac aacttacaaa aactaagcat aggcgcctac 120 aaattgcaaa tactcgaaag cgaaaagctt gatcatttaa aagacattca tcatcatatt 180 gtagtatgta ataaaaatta cttagttgtt cacaatgccg tcgagggtga tgccatgagt 240 gcagtcctaa tacttttaga tagcgttgtt ttgaaaaaag atcaaaacat atttatggtt 300 acttttccta gaccatttaa gttttctgtg cctataagtg ttgaaaaaga acaagaagaa 360 gaggaattag aaggtataaa taattcaaga atggtaacag aaattgatca agaggagatt 420 gtttcgagca ccgacatcga tattgaaatg cccgaattta aaattcccga accaaaaccg 480 tctactagta agttgtccgt gtttgataga ttcaatgtcg agtcaaaaca atagct 536 <210> 89 <211> 177 <212> PRT
<213> AsGV
<400> 89 Met Ala Thr Thr Ser Val Asp Arg Asp Ser Ile Ile Ile Tyr Pro Val Leu Glu Glu Glu Gln Ile Met Phe Lys Val Lys Glu Asp Tyr Asn Leu Gln Lys Leu Ser Ile Gly Ala Tyr Lys Leu Gln Ile Ser Glu Lys Leu Asp His Leu Lys Asp Ile His His His Ile Val Val Cys Asn Lys Asn Tyr Leu Val Val His Asn Ala Val Glu Gly Asp Ala Met Ser Ala Val Leu Ile Leu Leu Asp Ser Val Val Leu Lys Lys Asp Gln Asn Ile Phe Met Val Thr Phe Pro Arg Pro Phe Lys Phe Ser Val Pro Ile Ser Val Glu Lys Glu Gln Glu Glu Glu Glu Leu Glu Gly Ile Asn Asn Ser Arg Met Val Thr Glu Ile Asp Gln Glu Glu Ile Val Ser Ser Thr Asp Ile Asp Ile Glu Met Pro Glu Phe Lys Ile Pro Glu Pro Lys Pro Ser Thr Ser Lys Leu Ser Val Phe Asp Arg Phe Asn Val Glu Ser Lys Gln Cys Thr <210> 90 <211> 548 1308 SEQ.LISTING.txt <212> DNA
<213> AsGV
<400> 90 atgtctaaca acacgcaaca atacacgtta tacaatccga gaagttccgt ggagtctcgt 60 acgcggtaca tggtagatgt gttctgcaga gattggtcga gtgttttgga cgcatacacg 120 gtatttgtac aaggcggtac tcattttttg gtcaatggca aaaatttgtt gcagatgata 180 aaacaatgtc ccacgctgga ggagagcgag caatcgaccg tgggaaatat taaaaagacg 240 aagaaaaaaa gagaaatatg ttttgaaacg ctcaagaaac gctcagacat aattgccaag 300 tatcgtgaaa cattttaccg ttttaaagac gcaaacacac tgcccgattt tgaagctttg 360 gtacaacgac cgagaaacaa acgttttgga aatagattaa agttttcttt tctagtaatc 420 aaaaatatac aatgtaagcg ttgcgaaaac aatgtgtgtg tttacaacgc attaaaatca 480 ttttacgaaa acgataaaaa gtgtgttgat gaagtggatc gtttagtgat taaagaggct 540 gaataact 548 <210> 91 <211> 183 <212> PRT
<213> AsGV
<400> 91 Met Ser Asn Asn Thr Gln Gln Tyr Thr Leu Tyr Asn Pro Arg Ser Ser Val Glu Ser Arg Thr Arg Tyr Met Val Asp Val Phe Cys Arg Asp Trp Ser Ser Val Leu Asp Ala Tyr Thr Val Phe Val Gln Gly Gly Thr His Phe Leu Val Asn Gly Lys Asn Leu Leu Gln Met Ile Lys Gln Cys Pro Thr Leu Glu Glu Ser Glu Gln Ser Thr Val Gly Asn Ile Lys Lys Thr Lys Lys Lys Arg Glu Ile Cys Phe Glu Thr Leu Lys Lys Arg Ser Asp Ile Ile Ala Lys Tyr Arg Glu Thr Phe Tyr Arg Phe Lys Asp Ala Asn Thr Leu Pro Asp Phe Glu Ala Leu Val Gln Arg Pro Arg Asn Lys Arg Phe Gly Asn Arg Leu Lys Phe Ser Phe Leu Val Ile Lys Asn Ile Gln Cys Lys Arg Cys Glu Asn Asn Val Cys Val Tyr Asn Ala Leu Lys Ser Phe Tyr Glu Asn Asp Lys Lys Cys Val Asp Glu Val Asp Arg Leu Val Ile Lys Glu Ala Glu Cys Thr <210> 92 <211> 764 <212> DNA
<213> AsGV
1308 SEQ.LISTING.txt <400> 92 atgtatacta gcgatcaact tcttcaaatt tggacgtctg ttaactacag agaggacaga 60 tattgggctt ttatgaagag cgacggtacg tggcgccatt cagattcaca gttttcaaaa 120 acctcgacat ataacagttt tgatcaattt gagaaggctg taaaattgtt ggacgcgagg 180 gatatacacg ttaaaaaaac cgtgagcggt ggaagagaat gggtaattga tgtggaccac 240 gacgactccg atcaacgcaa gatacgcctt aaaaatgcaa tagcacacgt cacgttcgcc 300 gagttttttg gatcaaattg tgagaaaatc atgttttccg gaaacagagg tcttcatatt 360 tggttaaatc atcacaagtt tgatatgcaa gcctcggcgc aaacgagacg ttattattat 420 aatagtgttc ttaaaaagcc aatctttctt aactttgctt tacttcaaaa aggctctttg 480 ggttggtgtt tcagaaatgc gcttaaagtt ccgtggatag aacgtcaaat acaacaattg 540 tatccgcata ttagtttgaa taacaacaaa atgttgttaa aagagtttta tccatacgtc 600 gacaaacaag tatttgaaag cacgaaacaa ataagagcgc cttatagttt taacactaaa 660 ggaagacaat ttaatcaacc acacatattg gaatggacag tctcgttaaa tatgtgcgtt 720 cctactggtt cggaaacgac agcaacagca aagacgaagt aact 764 <210> 93 <211> 251 <212> PRT
<213> AsGV
<400> 93 Met Tyr Thr Ser Asp Gln Leu Leu Gln Ile Trp Thr Ser Val Asn Tyr Arg Glu Asp Arg Tyr Trp Ala Phe Met Lys Ser Asp Gly Thr Trp Arg His Ser Asp Ser Gln Phe Ser Lys Thr Ser Thr Tyr Asn Ser Phe Asp Gln Phe Glu Lys Ala Val Lys Leu Leu Asp Ala Arg Asp Ile His Val Lys Lys Thr Val Ser Gly Gly Arg Glu Trp Val Ile Asp Val Asp His Asp Asp Ser Asp Gln Arg Lys Ile Arg Leu Lys Asn Ala Ile Ala His Val Thr Phe Ala Glu Phe Phe Gly Ser Asn Cys Glu Lys Ile Met Phe Ser Gly Asn Arg Gly Leu His Ile Trp Leu Asn His His Lys Phe Asp Met Gln Ala Ser Ala Gln Thr Arg Arg Tyr Tyr Tyr Asn Ser Val Leu Lys Lys Pro Ile Phe Leu Asn Phe Ala Leu Leu Gln Lys Gly Ser Leu Gly Trp Cys Phe Arg Asn Ala Leu Lys Val Pro Trp Ile Glu Arg Gln Ile Gln Gln Leu Tyr Pro His Leu Asn Asn Asn Lys Met Leu Leu Lys SEQ.LISTING.txt GluPhe Tyr Pro Tyr Val Asp Lys Gln Val Phe Glu Ser Thr Lys Gln IleArg Ala Pro Tyr Ser Phe Asn Thr Lys Gly Arg Gln Phe Asn Gln ProHis Ile Trp Thr Val Ser Leu Asn Met Cys Val Pro Thr Gly Ser GluThr Thr Ala Thr Ala Lys Thr Lys Cys Thr <210> 94 <211> 1343 <212> DNA
<213> AsGV
<400> 94 atggactccg agttactcaa gcacgttttt atagcaactt attttgactt agatcagcga 60 gatcacttga acagcgatgt gagacggttt ttaaacgagc caagcgaaga agatgttatt 120 tcttatcttg actatttgga ccgcatgcag cttaaaaata ttgttgtaga taaaagtgct 180 gatttattta aatacattaa accacagttt aaatatgttt gcgaaagaga gtacgacttg 240 gacattgtaa agtataatta ttcgggagtg tttttgcgaa aaggcgcggt agtatatgca 300 acaaatcttt tcgttgtgga ccccagtgat actatttcgt tttttataac aaagtttggt 360 atcgagaagg gatacacttc aatagaagag aaacatgtgg tgtgtaatgg aaccgacggt 420 gtttttttcg ggcgagctta tttggactgg ctgggtctaa aagtgtgcag cggtaacaag 480 tatagagagg atgaacatta tagactttac attattgggg aacatatggc ccagcagttt 540 atccagaaca atataggtgc tttggaagga agtgaattga gaaattttta caaaggcacc 600 cctcttacat atactaaaaa cgctgcaaac ataattaatc aaaaatcttt cgtaacagac 660 aacatggacg ttgtgttcga caattttgcg gaagagtttg atcaaaatgt agactatatt 720 aaattcgtcc aaagagatta tatttatgac gcctctaatt ttcccacaga tcttttagag 780 gagcttcaac agcattatgt ctctctcacc tctgtttata aaataataaa tcgttttcag 840 aaaagttcaa taccaatggt aggaaaagag ctggtagtgg accgttatgc cgtcacaaag 900 tacaaaaaga tgattaccac gcccgacttt gttttaccag gccgagagaa caatatgcac 960 atatttatac caagggattt tattcagctt agacacacgc tgaatgccgc ctttgttcct 1020 gagttaggta ttgtaatact ggcggagcat gttttctttg gagcaaatcg tgtacttgat 1080 tttgatccga gacgaggaga tttgtacgtg ttcgttaaaa gaaagacaac gattgataag 1140 gatgaagtat attatcacat aggtggggag ttttatttag aggagacaca atttgcctcc 1200 aaccaaatcc ccgtctttgt tcttgtgaga atcgataatg atttattagt aagagataat 1260 ttaagaactt ctcgtaaatt aaaggatttg aattataact gggtcgataa tactatttta 1320 aacttatttg taaaaaagta get 1343 <210> 95 <211> 444 <212> PRT
<213> AsGV
<400> 95 Met Asp Ser Glu Leu Leu Lys His Val Phe Ile Ala Thr Tyr Phe Asp 1308 SEQ.LISTING.txt Leu Asp Gln Arg Asp His Leu Asn Ser Asp Val Arg Arg Phe Leu Asn Glu Pro Ser Glu Glu Asp Val Ile Ser Tyr Leu Asp Tyr Leu Asp Arg Met Gln Leu Lys Asn Ile Val Val Asp Lys Ser Ala Asp Leu Phe Lys Tyr Ile Lys Pro Gln Phe Lys Tyr Val Cys Glu Arg Glu Tyr Asp Leu Asp Ile Val Lys Tyr Asn Tyr Ser Gly Val Phe Leu Arg Lys Gly Ala Val Val Tyr Ala Thr Asn Leu Phe Val Val Asp Pro Ser Asp Thr Ile Ser Phe Phe Ile Thr Lys Phe Gly Ile Glu Lys Gly Tyr Thr Ser Ile Glu Glu Lys His Val Val Cys Asn Gly Thr Asp Gly Val Phe Phe Gly Arg Ala Tyr Leu Asp Trp Leu Gly Leu Lys Val Cys Ser Gly Asn Lys Tyr Arg Glu Asp Glu His Tyr Arg Leu Tyr Ile Ile Gly Glu His Met Ala Gln Gln Phe Ile Gln Asn Asn Ile Gly Ala Leu Glu Gly Ser Glu Leu Arg Asn Phe Tyr Lys Gly Thr Pro Leu Thr Tyr Thr Lys Asn Ala Ala Asn Ile Ile Asn Gln Lys Ser Phe Val Thr Asp Asn Met Asp Val Val Phe Asp Asn Phe Ala Glu Glu Phe Asp Gln Asn Val Asp Tyr Ile Lys Phe Val Gln Arg Asp Tyr Ile Tyr Asp Asn Phe Pro Thr Asp Leu Leu Glu Glu Leu Gln Gln His Tyr Val Ser Leu Thr Ser Val Tyr Lys Ile Ile Asn Arg Phe Gln Lys Ser Ser Ile Pro Met Val Gly Lys Glu Leu Val Val Asp Arg Tyr Ala Val Thr Lys Tyr Lys Lys Met Ile Thr Thr Pro Asp Phe Val Leu Pro Gly Arg Glu Asn Asn Met His Ile Phe Ile Pro Arg Asp Phe Ile Gln Leu Arg His Thr Leu Asn Ala Ala Phe Val Pro Glu Leu Gly Ile Val Ile Leu Ala Glu His Val Phe Phe Gly Ala Asn Arg Val Leu Asp Phe Asp Pro Arg Arg Gly Asp Leu Tyr Val Phe Val Lys Arg Lys Thr Thr Ile Asp Lys Asp Glu Val Tyr Tyr His Ile Gly Gly Glu Phe Tyr Leu Glu Glu Thr Gln Phe Asn Gln Ile Pro SEQ.LISTING.txt Val Phe Val Leu Val Arg Ile Asn Asp Leu Leu Val Arg Asp Asn Asp Leu Arg Thr Ser Arg Lys Leu Asp Leu Asn Tyr Asn Trp Val Asp Lys Asn Thr Ile Leu Asn Leu Phe Lys Lys Cys Thr Val <210> 96 <211> 377 <212> DNA
<213> AsGV
<400> 96 atggataatt acgcaccaga tggagcgcat agacattatg aactggagag ggtacaaaag 60 gaaattctcc aacaacacaa gcgtattgaa tctcaattaa atctgctaag agacaatctt 120 cgatctattg gtaacacggt tatggggaac ggcacaacaa acgataacgg ttacgttgtt 180 cacactcgaa ctgcgctgaa caataactat cctagttata ataatcccaa ttatttagca 240 ataaacagag cggatcagcc agctaatctt tgttctccca cagccgcagc aagacctagc 300 gccgcttatt ataataacaa caataggtac aaccggaacg tcaactatcg taacaataga 360 atagtaccgt tttagct 377 <210> 97 <211> 126 <212> PRT
<213> AsGV
<400> 97 Met Asp Asn Tyr Ala Pro Asp Gly Ala His Arg His Tyr Glu Leu Glu Arg Val Gln Lys Glu Ile Leu Gln Gln His Lys Arg Ile Glu Ser Gln Leu Asn Leu Leu Arg Asp Asn Leu Arg Ser Ile Gly Asn Thr Val Met Gly Asn Gly Thr Thr Asn Asp Asn Gly Tyr Val Val His Thr Arg Thr Ala Leu Asn Asn Asn Tyr Pro Ser Tyr Asn Asn Pro Asn Tyr Leu Ala Ile Asn Arg Ala Asp Gln Pro Ala Asn Leu Cys Ser Pro Thr Ala Ala Ala Arg Pro Ser Ala Ala Tyr Tyr Asn Asn Asn Asn Arg Tyr Asn Arg Asn Val Asn Tyr Arg Asn Asn Arg Ile Val Pro Phe Cys Thr <210> 98 <211> 338 <212> DNA
<213> AsGV
1308 SEQ.LISTING.txt <400> 98 atgcaccagc ctaatattat acaattacta aaagtataca aagccaagtg taatatattg 60 gaagatcgtg tttacgagtt acaacaacaa tacgataaga cgcaatacga attaaaatgt 120 gtaaaagagt tgctcgccga aatttgcgaa atcgttgcgc cgcatcgtaa agatttggta 180 gacgaaatga tcgaaaatca cggtagacgc ttcagaacag aacatctccc gtacggccaa 240 cctcctctag ccaatctaaa atacaaacac caaaccgcaa ccacaaactt tgccccctcc 300 tctcccacta tctgggctaa tcttatgacg tcatagct 338 <210> 99 <211> 111 <212> PRT
<213> AsGV
<400> 99 Met His Gln Pro Asn Ile Ile Gln Leu Leu Lys Val Tyr Lys Ala Lys Cys Asn Ile Asp Arg Val Tyr Glu Leu Gln Gln Gln Tyr Asp Lys Thr Gln Tyr Glu Leu Lys Cys Val Lys Glu Leu Leu Ala Glu Ile Cys Glu Ile Val Ala Pro His Arg Lys Asp Leu Val Asp Glu Met Ile Glu Asn His Gly Arg Arg Phe Arg Thr Glu His Leu Pro Tyr Gly Gln Pro Pro Leu Ala Asn Leu Lys Tyr Lys His Gln Thr Ala Thr Thr Asn Phe Ala Pro Ser Ser Pro Thr Ile Trp Ala Asn Leu Met Thr Ser Cys Thr <210> 100 <211> 584 <212> DNA
<213> AsGV
<400> 100 atggacagtc tcgttaaata tgtgcgttcc tactggttcg gaaacgacag caacagcaaa 60 gacgaagtaa gaacaatttt agatagatgc tgtaaacgtg tagacgccgt agaaacttta 120 ctgaccaata agtttggaaa aatcgaccaa gatcttaacg aaatgaaaga agtcttcttg 180 aatgtttctt taatgctaaa acaggagcaa acagacgaat ctggccagga cgaagttgat 240 aaaaacagcc cgcgtttatc taacacatct tcatgctcca actcttcgga cggatctaat 300 ttggcggttt atgtaaagcc gcgaatcaat ggtcacacac agctacagta cgtgacgggt 360 cgcactaaac gatacaacac tcgtaaaagg ttttatcaag acattgacat gaaagaagtt 420 attgccggca aggaaagttc acccaggaag aaaattacaa aaattaatca taaactatta 480 1308 SEQ.LISTING.txt gagaaaggga ctgttgccaa tattggtgaa gatagtttta ttgtggcgca tgacgctgac 540 accgtatgtg atgttatcct aaatgaaaca ttaaaacaat aact 584 <210> 101 <211> 195 <212> PRT
<213> AsGV
<400> 101 Met Asp Sex Leu Val Lys Tyr Val Arg Ser Tyr Trp Phe Gly Asn Asp Ser Asn Ser Lys Asp Glu Val Arg Thr Ile Leu Asp Arg Cys Cys Lys Arg Val Asp Ala Val Glu Thr Leu Leu Thr Asn Lys Phe Gly Lys Ile Asp Gln Asp Leu Asn Glu Met Lys Glu Val Phe Leu Asn Val Ser Leu Met Leu Lys Gln Glu Gln Thr Asp Glu Ser Gly Gln Asp Glu Val Asp Lys Asn Ser Pro Arg Leu Ser Asn Thr Ser Ser Cys Ser Asn Ser Ser Asp Gly Ser Asn Leu Ala Val Tyr Val Lys Pro Arg Ile Asn Gly His Thr Gln Leu Gln Tyr Val Thr Gly Arg Thr Lys Arg Tyr Asn Thr Arg Lys Arg Phe Tyr Gln Asp Ile Asp Met Lys Glu Val Ile Ala Gly Lys Glu Ser Ser Pro Arg Lys Lys Ile Thr Lys Ile Asn His Lys Leu Leu Glu Lys Gly Thr Val Ala Asn Ile Gly Glu Asp Ser Phe Ile Val Ala His Asp Ala Asp Thr Val Cys Asp Val Ile Leu Asn Glu Thr Leu Lys Gln Cys Thr <210> 102 <211> 302 <212> DNA
<213> AsGV
<400> 102 atggatgtac ttagtttccc gacattaata tttttgattc ttgttatttt aaaaatttac 60 atatttcatg gttataaaat gttacaacga aaagactggt ttatgaataa tatatgcatc 120 gacgggtatt acggcttcgc tgccgatcct ttcgagtgcg atgtttatta caaatgccca 180 gaaaaaatac ggttttactg cgacgttggt acgcagtatg acgcagacaa atctgtctgt 240 gtacccaatg atgaggtcaa cggttgttac gagataatga gaaggaggtt gctcatctga 300 1308 SEQ.LISTING.txt ct 302 <210> 103 <211> 101 <212> PRT
<213> AsGV
<400> 103 Met Asp Val Leu Ser Phe Pro Thr Leu Ile Phe Leu Ile Leu Val Ile Leu Lys Ile Tyr Ile Phe His Gly Tyr Lys Met Leu Gln Arg Lys Asp Trp Phe Met Asn Asn Ile Cys Ile Asp Gly Tyr Tyr Gly Phe Ala Ala Asp Pro Phe Glu Cys Asp Val Tyr Tyr Lys Cys Pro Glu Lys Ile Arg Phe Tyr Cys Asp Val Gly Thr Gln Tyr Asp Ala Asp Lys Ser Val Cys Val Pro Asn Asp Glu Val Asn Gly Cys Tyr Glu Ile Met Arg Arg Arg Leu Leu Ile Cys Thr <210> 104 <211> 899 <212> DNA
<213> AsGV
<400> 104 atgaaccgta caagaacaat tggacgagag ggagagagaa aggttgagaa ttacaggacg 60 gtaacggaaa taaccgatgc tgaaaattct tactcgaaac gttatgacgt cagcgattta 120 gttaataaaa atgaggctta tcaacgtcag caagagaagc gagaaatgta cttgatgctc 180 agcaagtacg tcgcgatggt gcttgatctc aaactgccag atttgaaaat tttgttcggc 240 tcaaacggaa cgccggaggc tattctcagt cttgtgtatc attcgctagc ttttgtcaat 300 acacagatgt ttccgcacag tacacgtttt gtggacatgc gctttattat aactagcgaa 360 cgtaagtttg caatccccgg cgaacccatt gtcttttatc gtagcatcaa ccccgacgac 420 gaccagactg tggtgtgttt cgtggaccgg cctggaatat tgcgcgtact tgagaagccc 480 gtggacgtca acgttgtttt tgaagaaaac gactgcaaaa acgaatacat gacaaaactg 540 tttgatcgga tcaaatcaac agagcatgct gcgccggtga atccttacga gagattcata 600 accaacgaat ttgtctgcaa cctcaatgaa tctaatctta aaatggatga aggatacata 660 actcaatttg ttattttatt aatactcttc acaaacgctt atattggata ctacaaatta 720 gtgcgcaccg attttcgaca atactttgat tttttattaa atcacgaaag tctaatacga 780 gaccaatcgg cgttgccaaa tctttgtaat ttatttactt caaaattcag cttctccgta 840 cagggggaag aaggaaaaaa gccaagttct ggcttaatat tcaaaaaatt tgactaact 899 <210> 105 <211> 298 <212> PRT
<213> AsGV
1308 SEQ.LISTING.txt <400> 105 Met Asn Arg Thr Arg Thr Ile Gly Arg Glu Gly Glu Arg Lys Val Glu Asn Tyr Arg Thr Val Thr Glu Ile Thr Asp Ala Glu Asn Ser Tyr Ser Lys Arg Tyr Asp Val Ser Asp Leu Val Asn Lys Asn Glu Ala Tyr Gln Arg Gln Gln Glu Lys Arg Glu Met Tyr Leu Met Leu Ser Lys Tyr Val Ala Met Val Leu Asp Leu Lys Leu Pro Asp Leu Lys Ile Leu Phe Gly Ser Asn Gly Thr Pro Glu Ala Ile Leu Ser Leu Val Tyr His Ser Leu Ala Phe Val Asn Thr Gln Met Phe Pro His Ser Thr Arg Phe Val Asp Met Arg Phe Ile Ile Thr Ser Lys Phe Ala Ile Pro Gly Glu Pro Ile Val Phe Tyr Arg Ser Ile Asn Pro Asp Asp Asp Gln Thr Val Val Cys Phe Val Asp Arg Pro Gly Ile Leu Arg Val Leu Glu Lys Pro Val Asp Val Asn Val Val Phe Glu Glu Asn Asp Cys Lys Asn Glu Tyr Met Thr Lys Leu Phe Asp Arg Ile Lys Ser Thr Glu His Ala Ala Pro Val Asn Pro Tyr Glu Arg Phe Ile Thr Asn Glu Phe Val Cys Asn Leu Asn Glu Ser Asn Leu Lys Met Asp Glu Gly Tyr Ile Thr Gln Phe Val Ile Leu Leu Ile Leu Phe Thr Asn Ala Tyr Ile Gly Tyr Tyr Lys Leu Val Arg Thr Asp Phe Arg Gln Tyr Phe Asp Phe Leu Leu Asn His Glu Ser Leu Ile Arg Asp Gln Ser Ala Leu Pro Asn Leu Cys Asn Leu Phe Thr Ser Lys Phe Ser Phe Ser Val Gln Gly Glu Glu Gly Lys Lys Pro Ser Ser Gly Leu Ile Phe Lys Lys Phe Asp Cys Thr <210> 106 <211> 470 <212> DNA
<213> AsGV

1308 SEQ.LISTING.txt <400> 106 atgacactta aagatttgta taacgaaatt ttaaagacac aacaagacat tgctgtgacc 60 tatggtagaa tagtatcgtt agagaatgat ttaaaaaaga agattgacac ggacaacaaa 120 tccgatacta ttgtaaacag attagaagat ctacagaatc aagtagacac cgcgcttaac 180 ctattagaaa aaataaacaa aaaacaaagc gaattagaac aagtagttga agtgttggaa 240 gatacaatta aacgtgacga atcagaccaa cctcaaacag acgaacggca aaataatctt 300 ttcaataata aagaagaaga agaaaacgta gaaaacgtta gtatagaatc cgaagaacaa 360 gttaaaagta ttagcgcaga ttctctagat acacaaacta aaaaggtaca gtttcgctca 420 agccaaagtt ctaatagttc agaagagagc gaaatagaat ctacataact 470 <210> 107 <211> 157 <212> PRT
<213> AsGV
<400> 107 Met Thr Leu Lys Asp Leu Tyr Asn Glu Ile Leu Lys Thr Gln Gln Asp Ile Ala Val Thr Tyr Gly Arg Ile Val Ser Leu Glu Asn Asp Leu Lys Lys Lys Ile Asp Thr Asp Asn Lys Ser Asp Thr Ile Val Asn Arg Leu Glu Asp Leu Gln Asn Gln Val Asp Thr Ala Leu Asn Leu Leu Glu Lys Ile Asn Lys Lys Gln Ser Glu Leu Glu Gln Val Val Glu Val Leu Glu Asp Thr Ile Lys Arg Asp Glu Ser Asp Gln Pro Gln Thr Asp Glu Arg Gln Asn Asn Leu Phe Asn Asn Lys Glu Glu Glu Glu Asn Val Glu Asn Val Ser Ile Glu Ser Glu Glu Gln Val Lys Ser Ile Ser Ala Asp Ser Leu Asp Thr Gln Thr Lys Lys Val Gln Phe Arg Ser Ser Gln Ser Ser Asn Ser Ser Glu Glu Ser Glu Ile Glu Ser Thr Cys Thr <210> 108 <211> 1394 <212> DNA
<213> AsGV
<400> 108 atggcaaact tttataaaat ggatgtagag gaagacgacg aagcggcacg tccaatcctt 60 ttagaaacgg cagactctga gtacgaatac gaagaagatg aggaagagga agaagatgaa 120 atgaaaccgc agaaatttaa aaaagaactg gagacggcgg cggtgtgcga aaacgtttta 180 1308 SEQ.LISTING.txt gatttgagca agggaccggt gctggatgaa atacgaatgg atctgtgcga cgattttaaa 240 ctaaccgacg atatgatgga cacttacaaa tggctaagta tgtacgagag tacatctacc 300 catatgtatg tttgccactt ggatatggat tacgttagta atgagaggtt cgcgagtgac 360 gtctatcaag actgttatca ttccctttat ggaaacgctt atgagtatta tgtgaagcaa 420 attaaaattt acataacggt cgcttgtcta cgctacaaca atatagatcc gaagaagttt 480 cctacagata tggtggataa gaagaaagat gtttccaaac tagcatattt tcttcagtgt 540 aaaacaagaa acggtttaac actaaagcag caactcatct atgcgcttca cagcgttaat 600 ttgatcggca taccatttaa agaaatcgct gaaattcacg ccaacttcga ctctgtggta 660 aataatcaaa gtttaaaaaa ccttaaaagc cgctatactt ggaaagggga agaagagaag 720 gttaaacgtt taaaagaaaa cacggataag ggtatgtcct cggtgcaaga gttgtttaaa 780 cacacatttc atcggggctt tatgcgtttt aaaaaggacc taactttggt gcacgaggat 840 tattttcgtt tgtttgaaac tgctgtgggt tataataaat taaaattgac accgtatcag 900 gacaccataa gcagcattaa atggatcttt aaagatattg ttaaagcgct tactgacaat 960 ttggctttgt taaattttaa aacgtttgag tctgatgaga aagaggttag agaatttttg 1020 aagctttctc agttaaaccc cgcgggggat gtaattttcc acacgaagac aaaacataga 1080 aatagagaac attatagatt aaattgtttt agaatggata gtgttcatgt ttgggtcaac 1140 acaatggtgt ttgataaaaa tgattctagt aagaagttgg atttagagag tttaattaaa 1200 gagtttaatt ggggttcgca ccatattatt aaagctaaat atgtttacaa tttaaaatta 1260 gcaaagttgc atatagaaac tgtaaaacta gttatacgtt atatcctgca aagaagagac 1320 tttagtcttc ttaaatacga tgttttacat caaaataaat tggagtacaa ttatattttt 1380 tgtagcactt aact 1394 <210> 109 <211> 465 <212> PRT
<213> AsGV
<400> 109 Met Ala Asn Phe Tyr Lys Met Asp Val Glu Glu Asp Asp Glu Ala Ala Arg Pro Ile Leu Leu Glu Thr Ala Asp Ser Glu Tyr Glu Tyr Glu Glu Asp Glu Glu Glu Glu Glu Asp Glu Met Lys Pro Gln Lys Phe Lys Lys Glu Leu Glu Thr Ala Ala Val Cys Glu Asn Val Leu Asp Leu Ser Lys Gly Pro Val Leu Asp Glu Ile Arg Met Asp Leu Cys Asp Asp Phe Lys Leu Thr Asp Asp Met Met Asp Thr Tyr Lys Trp Leu Ser Met Tyr Glu Ser Thr Ser Thr His Met Tyr Val Cys His Leu Asp Met Asp Tyr Val Ser Asn Glu Arg Phe Ala Ser Asp Val Tyr Gln Asp Cys Tyr His Ser Leu Tyr Gly Asn Ala Tyr Glu Tyr Tyr Val Lys Gln Ile Lys Ile Tyr Ile Thr Val Ala Cys Leu Arg Tyr Asn Asn Ile Asp Pro Lys Lys Phe 1308 SEQ.LISTING.txt Pro Thr Asp Met Val Asp Lys Lys Lys Asp Val Ser Lys Leu Ala Tyr Phe Leu Gln Cys Lys Thr Arg Asn Gly Leu Thr Leu Lys Gln Gln Leu Ile Tyr Ala Leu His Ser Val Asn Leu Ile Gly Ile Pro Phe Lys Glu Ile Ala Glu Ile His Ala Asn Phe Asp Ser Val Val Asn Asn Gln Ser Leu Lys Asn Leu Lys Ser Arg Tyr Thr Trp Lys Gly Glu Glu Glu Lys Val Lys Arg Leu Lys Glu Asn Thr Asp Lys Gly Met Ser Ser Val Gln Glu Leu Phe Lys His Thr Phe His Arg Gly Phe Met Arg Phe Lys Lys Asp Leu Thr Leu Val His Glu Asp Tyr Phe Arg Leu Phe Glu Thr Ala Val Gly Tyr Asn Lys Leu Lys Leu Thr Pro Tyr Gln Asp Thr Ile Ser Ser Ile Lys Trp Ile Phe Lys Asp Ile Val Lys Ala Leu Thr Asp Asn Leu Ala Leu Leu Asn Phe Lys Thr Phe Glu Ser Asp Glu Lys Glu Val Arg Glu Phe Leu Lys Leu Ser Gln Leu Asn Pro Ala Gly Asp Val Ile Phe His Thr Lys Thr Lys His Arg Asn Arg Glu His Tyr Arg Leu Asn Cys Phe Arg Met Asp Ser Val His Val Trp Val Asn Thr Met Val Phe Asp Lys Asn Asp Ser Ser Lys Lys Leu Asp Leu Glu Ser Leu Ile Lys Glu Phe Asn Trp Gly Ser His His Ile Ile Lys Ala Lys Tyr Val Tyr Asn Leu Lys Leu Ala Lys Leu His Ile Glu Thr Val Lys Leu Val Ile Arg Tyr Ile Leu Gln Arg Arg Asp Phe Ser Leu Leu Lys Tyr Asp Val Leu His Gln Asn Lys Leu Glu Tyr Asn Tyr Ile Phe Cys Ser Thr Cys Thr <210> 110 <211> 881 <212> DNA
<213> AsGV
<400> 110 1308 SEQ.LISTING.txt atgaatttca attctccagc gtgtaacctc acaaatcttt gcatctttca aggcgttcaa 60 ccaccagagt ttttaaactg tcgaccctac gaaccaccat gcattcagcc atacaacgac 120 gacggtacgt tcatttgtca gtatcacttg gcaaaatatt ttaaaatgga aaaaatggtg 180 gtacgaattg ggagcggagt ggggcccgag ttcgacatgt taatcggaaa aacgttgatt 240 caacagaaca ccgaagacgc tcgaagaatc atgatccctt taccttccaa ttttctcacc 300 tatttgcaag ttgaaaacat gtcagcgacg gaaaagtttg tattctatag tatatacgag 360 cgacaagact taattgccga actgtgccga ggtcttgtca gccaagaata ctacacagac 420 gacgtgctcg ccaaattaca gtcggtagtg agtcatatta tgggcttgat taatccggcc 480 atctattgta gaccagagat tatacgagac atcagaagct tcgacaatcc tccgggaaat 540 ggagtgcaga ccgcggtctt tgaccaaatg ccgccgtttc taaagaatct gattagacta 600 acggtgagac ctcaaactat gaccgtaagc aacactcaat tgttgttagc acaagtaccc 660 acttgtgatt tggtgcccga gcgcgggttg gtcgccgcca acttatacaa tcccactaaa 720 tcgcgcttcc tcgctaatcc gttaagagag ccgagattcc aagttagaac agtggtagaa 780 ttcgaaggaa gagcgacacg caggcaagaa ggtttgcagg gatatgaagt gtatgtggtc 840 aatagaccat tgtggttggg caccgaagtg attccttaac t 881 <210> 111 <211> 294 <212> PRT
<213> AsGV
<400> 111 Met Asn Phe Asn Ser Pro Ala Cys Asn Leu Thr Asn Leu Cys Ile Phe Gln Gly Val Gln Pro Pro Glu Phe Leu Asn Cys Arg Pro Tyr Glu Pro Pro Cys Ile Gln Pro Tyr Asn Asp Asp Gly Thr Phe Ile Cys Gln Tyr His Leu Ala Lys Tyr Phe Lys Met Glu Lys Met Val Val Arg Ile Gly Ser Gly Val Gly Pro Glu Phe Asp Met Leu Ile Gly Lys Thr Leu Ile Gln Gln Asn Thr Glu Asp Ala Arg Arg Ile Met Ile Pro Leu Pro Ser Asn Phe Leu Thr Tyr Leu Gln Val Glu Asn Met Ser Ala Thr Glu Lys Phe Val Phe Tyr Ser Ile Tyr Glu Arg Gln Asp Leu Ile Ala Glu Leu Cys Arg Gly Leu Val Ser Gln Glu Tyr Tyr Thr Asp Asp Val Leu Ala Lys Leu Gln Ser Val Val Ser His Ile Met Gly Leu Ile Asn Pro Ala Ile Tyr Cys Arg Pro Glu Ile Ile Arg Asp Ile Arg Ser Phe Asp Asn Pro Pro Gly Asn Gly Val Gln Thr Ala Val Phe Asp Gln Met Pro Pro Phe Leu Lys Asn Leu Ile Arg Leu Thr Val Arg Pro Gln Thr Met Thr 1308 SEQ.LISTING.txt Val Ser Asn Thr Gln Leu Leu Leu Ala Gln Val Pro Thr Cys Asp Leu Val Pro Glu Arg Gly Leu Val Ala Ala Asn Leu Tyr Asn Pro Thr Lys Ser Arg Phe Leu Ala Asn Pro Leu Arg Glu Pro Arg Phe Gln Val Arg Thr Val Val Glu Phe Glu Gly Arg Ala Thr Arg Arg Gln Glu Gly Leu Gln Gly Tyr Glu Val Tyr Val Val Asn Arg Pro Leu Trp Leu Gly Thr Glu Val Ile Pro Cys Thr <210> 112 <211> 761 <212> DNA
<213> AsGV
<400> 112 atgttggtag aaacgcccac ggtcattagg tacaagggaa gctgcgcttt attcatatat 60 agaatgttag acatgacgcg ggtggctcct tcgaaagaac tacaaagtgt gttgattaaa 120 gaagttaggt ttctttatca cctattttgt gtgaccgttt acggtgatcc ccgagccgaa 180 aatgtcgaaa aacttatttc atggtgtgtc tcattaggta aggatgtgaa gctggataat 240 tttaaagaca tgtacacgga ggctttgcta aattttaatt tagaaaacat tacaccgccc 300 caatttatgt tctcttttag caccatctgg gacagcattc attttatttg tttgatcgca 360 gacgaaatgg tagtaaatcg cgatagcttg gacattgata tggttcgtga aaatatcaaa 420 aacatcaaat ggatatttta caacatcttt attgtcctct tctgtcctat gtgcgccaaa 480 cactttctca ctattaactc atttccgtac gaggtagaaa aagttgaagt ggcgctgtat 540 aacgaaaaaa tgggagaccc cctcacctta gtacaagagt acaatagaag catgtccacc 600 aaaaatgttt tatacaccaa tcatttagtt tacgagtcta tgctgtttca caaccatgta 660 aacagctaca gaccaataca acaaaacaat gataagttaa acaaatttca aaagatggac 720 tggactctat acaaaaaatt gctaggcatt atcaattagc t 761 <210> 113 <211> 252 <212> PRT
<213> AsGV
<400> 113 Met Leu Val Glu Thr Pro Thr Val Ile Arg Tyr Lys Gly Ser Cys Ala Leu Phe Ile Tyr Arg Met Leu Asp Met Thr Arg Val Ala Pro Ser Lys Glu Leu Gln Ser Val Leu Ile Lys Glu Val Arg Phe Leu Tyr His Leu Phe Cys Val Thr Val Tyr Gly Asp Pro Arg Ala Glu Asn Val Glu Lys 1308 SEQ.LISTING.txt Leu Ile Ser Trp Cys Val Ser Leu Gly Lys Asp Val Lys Leu Asp Asn Phe Lys Asp Met Tyr Thr Glu Ala Leu Leu Asn Phe Asn Leu Glu Asn Ile Thr Pro Pro Gln Phe Met Phe Ser Phe Ser Thr Ile Trp Asp Ser Ile His Phe Ile Cys Leu Ile Ala Asp Glu Met Val Val Asn Arg Asp Ser Leu Asp Ile Asp Met Val Arg Glu Asn Ile Lys Asn Ile Lys Trp Ile Phe Tyr Asn Ile Phe Ile Val Leu Phe Cys Pro Met Cys Ala Lys His Phe Leu Thr Ile Asn Ser Phe Pro Tyr Glu Val Glu Lys Val Glu Val Tyr Asn Glu Lys Met Gly Asp Pro Leu Thr Leu Val Gln Glu Tyr Asn Arg Ser Met Ser Thr Lys Asn Val Leu Tyr Thr Asn His Leu Val Tyr Glu Ser Met Leu Phe His Asn His Val Asn Ser Tyr Arg Pro Ile Gln Gln Asn Asn Asp Lys Leu Asn Lys Phe Gln Lys Met Asp Trp Thr Leu Tyr Lys Lys Leu Leu Gly Ile Ile Asn Cys Thr <210> 114 <211> 410 <212> DNA
<213> AsGV
<400> 114 atgaccggag gcgataaagc aatgttgtgg tacgacactt acggtttttc tgttttgtgt 60 gtttttgatt taattcaatt taagcattat ttagaacaaa ttgcatttac ggaagacgaa 120 ttagacattg gacgaaccgt aaacaagctc gttgatactg tttggaaaga tgtgaaagtt 180 tgtttagaag atgaattaat gatgtattat agactatgtc aagattgtgg cgaaatagga 240 gaccgaaaca taagtaactg tgaacaagtt tctcttaaaa gtgtagtgtg taagaagtgt 300 ggaaattgtc tcgtagtaca agacccaagg tttatttacg aacggtccga cgcagaatac 360 ttgctggaag aaataaatga aataaacaac aatccgacag attattaact 410 <210> 115 <211> 137 <212> PRT
<213> AsGV
<400> 115 Met Thr Gly Gly Asp Lys Ala Met Leu Trp Tyr Asp Thr Tyr Gly Phe 1308 SEQ.LISTING.txt Ser Val Leu Cys Val Phe Asp Leu Ile Gln Phe Lys His Tyr Leu Glu Gln Ile Ala Phe Thr Glu Asp Glu Leu Asp Ile Gly Arg Thr Val Asn Lys Leu Val Asp Thr Val Trp Lys Asp Val Lys Val Cys Leu Glu Asp Glu Leu Met Met Tyr Tyr Arg Leu Cys Gln Asp Cys Gly Glu Ile Gly Asp Arg Asn Ile Ser Asn Cys Glu Gln Val Ser Leu Lys Ser Val Val Cys Lys Lys Cys Gly Asn Cys Leu Val Val Gln Asp Pro Arg Phe Ile Tyr Glu Arg Ser Asp Ala Glu Tyr Leu Leu Glu Glu Ile Asn Glu Ile Asn Asn Asn Pro Thr Asp Tyr Cys Thr <210> 116 <211> 3461 <212> DNA
<213> AsGV
<400> 116 atgatactaa attcttacca aacgcacgga gtgcctactt caaaagattg tgtcttcaat 60 aatcactggc tattttataa cgcccggagc gatatttata aaataaagga ttgctcagac 120 atggattttt tggtggagct actgacctgc gcagcgacag aagagcacga ctggtgtcac 180 gtggcaaatt tttacaacac caaagtgaaa ccttacatgc tgcgtacaga ttacgagcgc 240 ctgttgaatc aagcaaaact accgtgcttt aaggatttaa tggacggtag cgccaacgac 300 atcgtctttg ggggtaaata tgttgtttgg agtaatatga gcgcgaggtt tttgggctgg 360 cttctgtacc tcaaaattaa ttacaacatc accctaagcg cgcacatacc acttttcaat 420 catcgtgatt tgggtcctgt aaatttattt agcaacagcc aaatcaactt tgatttattt 480 tgctctctta aagtcgacga caaacgatgg tttcaaaacg gacctcatac cgacgcgccg 540 catcacgtca tggatgttga tatcaatcat gaagacagtg tgcgcaccgt tgagctcaag 600 tttggtaacc attatgtggg ttcaaaaaac cagattttgt tgaattatct cgtcaacaac 660 gatctagtgg tagcgtgtcg ctttaccgat aagtttgcgt atttgggaga gattgatttg 720 aacagactgc gctacgattc ggtacaagtt tttttgaccg acgatggaga agaacccgtt 780 gaaacgtgca ttttgcccgc taagagtgac atcaaaattt caccatcctc aaattttcac 840 gaagactttg atcgttacat taaagagtgt tttgatgaga tcgcgagtta catgtgcgaa 900 gccgccccca gcaacgactt tggtgagaat atgtttctat tgaaatattt ggaactcagc 960 gagtttagaa cttttccgta tttaattata aatgtctgga agtattgcgc gtcacacatt 1020 aaatttcaaa accaggagaa ggaagaggac atttttttgt ttttaatgct tttgtgcaag 1080 cacgctctcg gatttgcaaa ctatcgagac gaagactttg acgaggaaga aaaacgcaag 1140 atggaatgtt tgtacgaaga gaattttatt tacgttgcat ctaaagatag cgccaaaaaa 1200 tttttgaaga gccttaaatt ttttactgag cctcaaaaag ctttgggata ttattttgcg 1260 atacattttg aaatatttaa aaacaccgaa gaatggaaca ttaccagttc cttggtaaaa 1320 acgaccaagt tagacgattc tgtcaaaagt tttggtttct ttaaaaaaat taaagataac 1380 gaagtcagtt atatttttaa tggaaaaata tatgaatatg tcaagaacaa aaaagagcac 1440 1308 SEQ.LISTING.txt gacatagcaa gtctctatga aaaagctgac gaaatccaaa caaccacatt gaaatttaat 1500 catcttctca atttttacat gacagaagac gggatgtttg atgtgtgcaa aaaaaaattc 1560 atagaaccct gcccttttgt gattgtatct tctctaaaga aaaattttat ttgcaaaaat 1620 caagaatttg ttgacagacg cgcttttgac gccatctttg ccgctatgaa aaacgatata 1680 ctcctattga aggcgtatca cgccaaaaag tttgaacggg attttaatct aactaaagat 1740 ggtattcgcg attgtgccat gctcgacgga aaactgttgg atgttcaaaa caagttgatg 1800 gataaactaa aaataatgat caagagcgtt ctatcttacc atcatagtga tctagtaatg 1860 ttgatgatta agttaaattt gaatgatcat ttacacaatt tcatctcacg cggtcaagac 1920 attgatttac tgtgtttgca attggctgta acattacaac ttttgtggcc caacagctct 1980 gttactagtt atatatgggg ctatttagca acgtgttatg atgaatttct agacattgcg 2040 gaacagtgtg ataggccaat tcttttgcaa gagagtttgt ttctaaacaa aaaggtcatc 2100 attgaaaagc tacataatta cattcgcctt aatggggcag aaatgttttt aaataacacc 2160 gtagcggatc aagtggaaga gtttgtgcaa gatctaaaca ttggttctgc taactccaaa 2220 aaattgtacg aagccaatag agtggttaag aaaattaatt taacctttaa caaattgaaa 2280 aagatccctc ttcaatacaa catatggaca gatagattga tagaatttga tagcctcaac 2340 gacgatatgt attcgtggct tactcgcttt tatatgcgca tgtatcttaa taaactttcc 2400 ttgaaaacta caaacaagaa cctgttgaac aattttatac aaggtttttg ctattttaga 2460 ttattgacaa attttaacat caccaattcc aaagcgatta tcaatttttg cgcgtctctt 2520 gccattccaa cagattatga gaaaatgtgt ttggtcatca cctccgagcc caattgcgga 2580 aagtcgtctc tgttcgaact actagataaa attattttag tttacaagtg tgacaggcac 2640 atatatgatt taaacaatca ggacaagagt tcaagaatta agagatttga gtctcagttg 2700 tacataatga acgaggcgga aataatgtca aagggttatt taaagagtat tgcagacagc 2760 accaaatttg agtttgcaaa caagaaatat ggacccgaag aatacttttg tgccaactac 2820 aaagttatga tcactaataa cgatatgctt ttcattcgag acggttacga taaggcgtgc 2880 agtaaccgta ttggtcaaat ttacattgac catagtttcg agagcgatat tgagcctttt 2940 aatgggagca tttacgaaaa ttacattcgt aaaaggtacc atgaaataaa ggacatcaac 3000 tcaaaactta cctcgccagt aacacaattt ctgggaaacg ttctttatta caactcggat 3060 ccaaagactg ggtttgttta ttacaaaaat attctacaag gggataaatg ttacaagcat 3120 aacaagaagt gtctatatat ctacaataac acacttgaag cgcttttgta tgttttagat 3180 attaaggagg taaagggtgc gccgggtttt actgaagcga ttcttttaga catgattaca 3240 aagtgtgtaa acattgtgaa gcatatggtt cattacaaaa tgcacgagcg ctgtgatgag 3300 agtagacttt ttggtgaatt tcgtaaaaag tacggcaaga gtcgcttctt caacgctgac 3360 acgtgctctt atgaaaactt gaccattgcc aagtcggaaa agtatttccg caaagataga 3420 cctaagttta agtcgaacat tgatgatgat atgatgtaac t 3461 <210> 117 <211> 1154 <212> PRT
<213> AsGV
<400> 117 Met Ile Leu Asn Ser Tyr Gln Thr His Gly Val Pro Thr Ser Lys Asp Cys Val Phe Asn Asn His Trp Leu Phe Tyr Asn Ala Arg Ser Asp Ile Tyr Lys Ile Lys Asp Cys Ser Asp Met Asp Phe Leu Val Glu Leu Leu Thr Cys Ala Ala Thr Glu Glu His Asp Trp Cys His Val Ala Asn Phe 1308 SEQ.LISTING.txt Tyr Asn Thr Lys Val Lys Pro Tyr Met Leu Arg Thr Asp Tyr Glu Arg Leu Leu Asn Gln Ala Lys Leu Pro Cys Phe Lys Asp Leu Met Asp Gly Ser Ala Asn Asp Ile Val Phe Gly Gly Lys Tyr Val Val Trp Ser Asn Met Ser Ala Arg Phe Leu Gly Trp Leu Leu Tyr Leu Lys Ile Asn Tyr Asn Ile Thr Leu Ser Ala His Ile Pro Leu Phe Asn His Arg Asp Leu Gly Pro Val Asn Leu Phe Ser Asn Ser Gln Ile Asn Phe Asp Leu Phe Cys Ser Leu Lys Val Asp Asp Lys Arg Trp Phe Gln Asn Gly Pro His Thr Asp Ala Pro His His Val Met Asp Val Asp Ile Asn His Glu Asp Ser Val Arg Thr Val Glu Leu Lys Phe Gly Asn His Tyr Val Gly Ser Lys Asn Gln Ile Leu Leu Asn Tyr Leu Val Asn Asn Asp Leu Val Val Ala Cys Arg Phe Thr Asp Lys Phe Ala Tyr Leu Gly Glu Ile Asp Leu Asn Arg Leu Arg Tyr Asp Ser Val Gln Val Phe Leu Thr Asp Asp Gly Glu Glu Pro Val Glu Thr Cys Ile Leu Pro Ala Lys Ser Asp Ile Lys Ile Ser Pro Ser Ser Asn Phe His Glu Asp Phe Asp Arg Tyr Ile Lys Glu Cys Phe Asp Glu Ile Ala Ser Tyr Met Cys Glu Ala Ala Pro Ser Asn Asp Phe Gly Glu Asn Met Phe Leu Leu Lys Tyr Leu Glu Leu Ser Glu Phe Arg Thr Phe Pro Tyr Leu Ile Ile Asn Val Trp Lys Tyr Cys Ala Ser His Ile Lys Phe Gln Asn Gln Glu Lys Glu Glu Asp Ile Phe Leu Phe Leu Met Leu Leu Cys Lys His Ala Leu Gly Phe Ala Asn Tyr Arg Asp Glu Asp Phe Asp Glu Glu Glu Lys Arg Lys Met Glu Cys Leu Tyr Glu Glu Asn Phe Ile Tyr Val Ala Ser Lys Asp Ser Ala Lys Lys Phe Leu Lys Ser Leu Lys Phe Phe Thr Glu Pro Gln Lys Ala Leu Gly Tyr Tyr Phe Ala Ile His Phe Glu Ile Phe Lys Asn Thr Glu Glu Trp Asn Ile Thr Ser Ser Leu Val Lys Thr Thr Lys Leu Asp Asp Ser Val 1308 SEQ.LISTING.txt Lys Ser Phe Gly Phe Phe Lys Lys Ile Lys Asp Asn Glu Val Ser Tyr Ile Phe Asn Gly Lys Ile Tyr Glu Tyr Val Lys Asn Lys Lys Glu His Asp Ile Ala Ser Leu Tyr Glu Lys Ala Asp Glu Ile Gln Thr Thr Thr Leu Lys Phe Asn His Leu Leu Asn Phe Tyr Met Thr Glu Asp Gly Met Phe Asp Val Cys Lys Lys Lys Phe Ile Glu Pro Cys Pro Phe Val Ile Val Ser Ser Leu Lys Lys Asn Phe Ile Cys Lys Asn Gln Glu Phe Val Asp Arg Arg Ala Phe Asp Ala Ile Phe Ala Ala Met Lys Asn Asp Ile Leu Leu Leu Lys Ala Tyr His Ala Lys Lys Phe Glu Arg Asp Phe Asn Leu Thr Lys Asp Gly Ile Arg Asp Cys Ala Met Leu Asp Gly Lys Leu Leu Asp Val Gln Asn Lys Leu Met Asp Lys Leu Lys Ile Met Ile Lys Ser Val Leu Ser Tyr His His Ser Asp Leu Val Met Leu Met Ile Lys Leu Asn Leu Asn Asp His Leu His Asn Phe Ile Ser Arg Gly Gln Asp Ile Asp Leu Leu Cys Leu Gln Leu Ala Val Thr Leu Gln Leu Leu Trp Pro Asn Ser Ser Val Thr Ser Tyr Ile Trp Gly Tyr Leu Ala Thr Cys Tyr Asp Glu Phe Leu Asp Ile Ala Glu Gln Cys Asp Arg Pro Ile Leu Leu Gln Glu Ser Leu Phe Leu Asn Lys Lys Val Ile Ile Glu Lys Leu His Asn Tyr Ile Arg Leu Asn Gly Ala Glu Met Phe Leu Asn Asn Thr Val Ala Asp Gln Val Glu Glu Phe Val Gln Asp Leu Asn Ile Gly Ser Ala Asn Ser Lys Lys Leu Tyr Glu Ala Asn Arg Val Val Lys Lys Ile Asn Leu Thr Phe Asn Lys Leu Lys Lys Ile Pro Leu Gln Tyr Asn Ile Trp Thr Asp Arg Leu Ile Glu Phe Asp Ser Leu Asn Asp Asp Met Tyr Ser Trp Leu Thr Arg Phe Tyr Met Arg Met Tyr Leu Asn Lys Leu Ser Leu Lys Thr Thr Asn Lys Asn Leu Leu Asn Asn Phe Ile Gln Gly Phe Cys Tyr Phe Arg Leu Leu Thr Asn Phe Asn Ile Thr Asn Ser Lys Ala 1308 SEQ.LISTING.txt Ile Ile Asn Phe Cys Ala Ser Leu Ala Ile Pro Thr Asp Tyr Glu Lys Met Cys Leu Val Ile Thr Ser Glu Pro Asn Cys Gly Lys Ser Ser Leu Phe Glu Leu Leu Asp Lys Ile Ile Leu Val Tyr Lys Cys Asp Arg His Ile Tyr Asp Leu Asn Asn Gln Asp Lys Ser Ser Arg Ile Lys Arg Phe Glu Ser Gln Leu Tyr Ile Met Asn Glu Ala Glu Ile Met Ser Lys Gly Tyr Leu Lys Ser Ile Ala Asp Ser Thr Lys Phe Glu Phe Ala Asn Lys Lys Tyr Gly Pro Glu Glu Tyr Phe Cys Ala Asn Tyr Lys Val Met Ile Thr Asn Asn Asp Met Leu Phe Ile Arg Asp Gly Tyr Asp Lys Ala Cys Ser Asn Arg Ile Gly Gln Ile Tyr Ile Asp His Ser Phe Glu Ser Asp Ile Glu Pro Phe Asn Gly Ser Ile Tyr Glu Asn Tyr Ile Arg Lys Arg Tyr His Glu Ile Lys Asp Ile Asn Ser Lys Leu Thr Ser Pro Val Thr Gln Phe Leu Gly Asn Val Leu Tyr Tyr Asn Ser Asp Pro Lys Thr Gly Phe Val Tyr Tyr Lys Asn Ile Leu Gln Gly Asp Lys Cys Tyr Lys His Asn Lys Lys Cys Leu Tyr Ile Tyr Asn Asn Thr Leu Glu Ala Leu Leu Tyr Val Leu Asp Ile Lys Glu Val Lys Gly Ala Pro Gly Phe Thr Glu Ala Ile Leu Leu Asp Met Ile Thr Lys Cys Val Asn Ile Val Lys His Met Val His Tyr Lys Met His Glu Arg Cys Asp Glu Ser Arg Leu Phe Gly Glu Phe Arg Lys Lys Tyr Gly Lys Ser Arg Phe Phe Asn Ala Asp Thr Cys Ser Tyr Glu Asn Leu Thr Ile Ala Lys Ser Glu Lys Tyr Phe Arg Lys Asp Arg Pro Lys Phe Lys Ser Asn Ile Asp Asp Asp Met Met Cys Thr <210> 118 <211> 602 <212> DNA

<213> AsGV
1308 SEQ.LISTING.txt <400> 118 atgaaccact cgaccgtgcc ttctctcgtg ccgtttgacg gtagctcgct atataaaagt 60 acccaccatc actattgcgg tttttatagc ttgtttatct tagctccaat aatcgacgac 120 actgtagtgg ttgatggaaa acaatacaaa ttatctgaag agaacgccat tgattgggca 180 tacgacggga ccgatactat aataacggaa aagcgtctac tttatacgga gcatcctttg 240 gaaccaaaca cactaattta caacgttaat cacgaaattg ttggaatatt gctgcgttat 300 atggtgacga aggatggtga atattgttat gcgattcaag acggttttaa gttgtacaac 360 aaccatttaa cggacacgaa tattgtggtg agagaaaaga aaaaacttat tgtgtatgcg 420 gatcaacaat ttgacactaa agaagatttg atgaagtatc taaaagaagg gaagaaaagc 480 gctggtagag gagccatatt atatcataaa ggggggaggg acgcccaact tgtattgtat 540 gaaaatggaa gaaacttgag caattctcat cttaggcgtc gtgtgtttgg agtgctttga 600 ct 602 <210> 119 <211> 201 <212> PRT
<213> AsGV
<400> 119 Met Asn His Ser Thr Val Pro Ser Leu Val Pro Phe Asp Gly Ser Ser Leu Tyr Lys Ser Thr His His His Tyr Cys Gly Phe Tyr Ser Leu Phe Ile Leu Ala Pro Ile Ile Asp Asp Thr Val Val Val Asp Gly Lys Gln Tyr Lys Leu Ser Glu Glu Asn Ala Ile Asp Trp Ala Tyr Asp Gly Thr Asp Thr Ile Ile Thr Glu Lys Arg Leu Leu Tyr Thr Glu His Pro Leu Glu Pro Asn Thr Leu Ile Tyr Asn Val Asn His Glu Ile Val Gly Ile Leu Leu Arg Tyr Met Val Thr Lys Asp Gly Glu Tyr Cys Tyr Ala Ile Gln Asp Gly Phe Lys Leu Tyr Asn Asn His Leu Thr Asp Thr Asn Ile Val Val Arg Glu Lys Lys Lys Leu Ile Val Tyr Ala Asp Gln Gln Phe Asp Thr Lys Glu Asp Leu Met Lys Tyr Leu Lys Glu Gly Lys Lys Ser Ala Gly Arg Gly Ala Ile Leu Tyr His Lys Gly Gly Arg Asp Ala Gln Leu Val Leu Tyr Glu Asn Gly Arg Asn Leu Ser Asn Ser His Leu Arg Arg Arg Val Phe Gly Val Leu Cys Thr 1308 SEQ.LISTING.txt <210> 120 <211> 2181 <212> DNA
<213> AsGV
<400> 120 atggcgcaac ctactagttt ggatttgatg aacgccggaa ggtattcgtc aggtatacgc 60 gacttgcatt acattttcaa gtggcgtaaa aagtttcctc atatctttac agattacacc 120 attagatatg ctacaccggc cgattattac gtaccacccg ctttactata caagagcgcg 180 attgttgtag acgtaaaatt tagtaaagag ggttgtgatg ctatgtcttg ctttccgtac 240 accgagacgg gagtgattga ttttttaaca acacctatcg gaggatatac tcaaacttcc 300 gaaactgcga ttcaatacaa tcagcccgcc tgttttaact tagatcccgc tctagcagca 360 agaaatcagc agacacaatc tatagaattg ttatatagaa acaataaatg tataatgggt 420 gatagtttta cgaaaatgta tttcaatagt ccatatcttc gcacagacga gcatatagtg 480 agaggcgtgg acgacgttcc agcctttaac gcatataacg aagaagatcc cgtcttcccg 540 gaacgcgtga aagggcgttt taatcaggcg tattgtcgtc gttttggtcg tgaggaagag 600 aataattcgt gccgccagca atggtgggag atacttgtgg gttttgtgtt aggtgacatg 660 atttatacga cttttaaaat aatgggaaat agagtgttgg cagatttgcg taattacgat 720 taccgagcac cttccgctct tcttccgccc agaaagccgc ccgatggtga tgcgctatta 780 gccttttggt taagtaggcg cgataaagcc atagatgggg agcttgaaga tggattttta 840 aattgtgatt ttaaaattac accgcaacag gaaatcagtt atgtcgctga aaaaggctat 900 acggttcaaa tggcgagaac aaaatttgaa gaggcggcgg acgttttaaa cacaatgtta 960 gaggagcgct acaaagtcct acatggtttt gtaaatgcaa aatctaaacc tttgggcgca 1020 ccaaggcaat ttgttttaga gagagatccg gaaacaagag aaattcgaac caacgacagt 1080 ctcgagcaca taataacaga ctttttagac gatcacaatt ttataatatc gattttggca 1140 gaattgggtt ttagtatact ggaggatctc ctcacggaca tgcttgttag tttaaataaa 1200 gtattaatac ctgcattgag agattattta attaatgcct ctgcccgttt tactgctaat 1260 ttattgggta acacatataa agcaatggta ttagaatccc ttaacagggc attgatatcc 1320 gcggtgtcgg ctgtagcgaa agctttggtt cgaggtatat cggcggcatt gtctgtcatt 1380 aatataattt tgatttttat tacaatagtc gatttggtgc tcatgttctg ggacccgtac 1440 ggttatagca tgatgtttcc gcgcggctat ctggacgatc tttcaaacgc cttcttgggg 1500 gcttattacg aaagtttaga gaccggctct agagaattaa ttgaatttcg accgatacac 1560 ttctttcatc tggtagaaga agaaagcaat actaatttta tgggggagga gggtttagcg 1620 attggagatt atttgttcaa cttggaggta aatagtaacg gccaaatgat aaactgggat 1680 acgggcggca caattacgga ctttgacgaa gcggatttgg tgggagctgc gctagctaca 1740 aacgatactt ttaaatattt taaatggtac tgctcacggc acaacaagct agtggaacca 1800 aatcaattgc tcgaagcgag cacaatgatg ggctgttttg gtttagttct tgcaggcggt 1860 ctcttactgt acaccatggc ggattataaa aatttaactc aaaaacagtc ggcgtctctg 1920 ctgatggtgt ttttaatagt gttaattgtt tgtatttgct ttattgttct accatctata 1980 cattattata caacactcgc gctgcacgat gcgccaaggt tcgattagat tacattgcag 2040 actatataaa gctgcttgga cggctgatga aagcattcag tctctgtcgg cgtacagatt 2100 gtaaacatgg acgatttttc cgattcattt gttgtggctg ccgatttgaa cgacagttgc 2160 cacgatgtgc ttgttggtcc t 2181 <210> 121 <211> 671 <212> PRT

<213> AsGV
1308 SEQ.LISTING.txt <400> 121 Met Ala Gln Pro Thr Ser Leu Asp Leu Met Asn Ala Gly Arg Tyr Ser Ser Gly Ile Arg Asp Leu His Tyr Ile Phe Lys Trp Arg Lys Lys Phe Pro His Ile Phe Thr Asp Tyr Thr Ile Arg Tyr Ala Thr Pro Ala Asp Tyr Tyr Val Pro Pro Ala Leu Leu Tyr Lys Ser Ala Ile Val Val Asp Val Lys Phe Ser Lys Glu Gly Cys Asp Ala Met Ser Cys Phe Pro Tyr Thr Glu Thr Gly Val Ile Asp Phe Leu Thr Thr Pro Ile Gly Gly Tyr Thr Gln Thr Ser Glu Thr Ala Ile Gln Tyr Asn Gln Pro Ala Cys Phe Asn Leu Asp Pro Ala Ala Arg Asn Gln Gln Thr Gln Ser Ile Glu Leu Leu Tyr Arg Asn Asn Lys Cys Ile Met Gly Asp Ser Phe Thr Lys Met Tyr Phe Asn Ser Pro Tyr Leu Arg Thr Asp Glu His Ile Val Arg Gly Val Asp Asp Val Pro Ala Phe Asn Ala Tyr Asn Glu Glu Asp Pro Val Phe Pro Glu Arg Val Lys Gly Arg Phe Asn Gln Ala Tyr Cys Arg Arg Phe Gly Arg Glu Glu Glu Asn Asn Ser Cys Arg Gln Gln Trp Trp Glu Ile Leu Val Gly Phe Val Leu Gly Asp Met Ile Tyr Thr Thr Phe Lys Ile Met Gly Asn Arg Val Leu Ala Asp Leu Arg Asn Tyr Asp Tyr Arg Ala Pro Ser Ala Leu Leu Pro Pro Arg Lys Pro Pro Asp Gly Asp Ala Leu Leu Ala Phe Trp Leu Ser Arg Arg Asp Lys Ala Ile Asp Gly Glu Leu Glu Asp Gly Phe Leu Asn Cys Asp Phe Lys Ile Thr Pro Gln Gln Glu Ile Ser Tyr Val Ala Glu Lys Gly Tyr Thr Val Gln Met Ala Arg Thr Lys Phe Glu Glu Ala Ala Asp Val Leu Asn Thr Met Leu Glu Glu Arg Tyr Lys Val Leu His Gly Phe Val Asn Ala Lys Ser Lys Pro Leu Gly Ala Pro Arg Gln Phe Val Leu Glu Arg Asp Pro Glu Thr Arg Glu Ile Arg Thr Asn Asp Ser Leu Glu His Ile Ile Thr Asp Phe Leu Asp 1308 SEQ.LISTING.txt Asp His Asn Phe Ile Ile Ser Ile Leu Ala Glu Leu Gly Phe Ser Ile Asp Leu Leu Thr Asp Met Leu Val Ser Leu Asn Lys Val Leu Ile Pro Ala Leu Arg Asp Tyr Leu Ile Asn Ala Ser Ala Arg Phe Thr Ala Asn Leu Leu Gly Asn Thr Tyr Lys Ala Met Val Leu Glu Ser Leu Asn Arg Ala Leu Ile Ser Ala Val Ser Ala Val Ala Lys Ala Leu Val Arg Gly Ile Ser Ala Ala Leu Ser Val Ile Asn Ile Ile Leu Ile Phe Ile Thr Ile Val Asp Leu Val Leu Met Phe Trp Asp Pro Tyr Gly Tyr Ser Met Met Phe Pro Arg Gly Tyr Leu Asp Asp Leu Ser Asn Ala Phe Leu Gly Ala Tyr Tyr Glu Ser Leu Glu Thr Gly Ser Arg Glu Leu Ile Glu Phe Arg Pro Ile His Phe Phe His Leu Val Glu Glu Glu Ser Asn Thr Asn Phe Met Gly Glu Glu Gly Leu Ala Ile Gly Asp Tyr Leu Phe Asn Leu Glu Val Asn Ser Asn Gly Gln Met Ile Asn Trp Asp Thr Gly Gly Thr Ile Thr Asp Phe Asp Glu Ala Asp Leu Val Gly Ala Ala Thr Asn Asp Thr Phe Lys Tyr Phe Lys Trp Tyr Cys Ser Arg His Asn Lys Leu Val Glu Pro Asn Gln Leu Leu Glu Ala Ser Thr Met Met Gly Cys Phe Gly Leu Val Leu Ala Gly Gly Leu Leu Leu Tyr Thr Met Ala Asp Tyr Lys Asn Leu Thr Gln Lys Gln Ser Ala Ser Leu Leu Met Val Phe Leu Ile Val Leu Ile Val Cys Ile Cys Phe Ile Val Leu Pro Ser Ile His Tyr Tyr Thr Thr Leu Ala Leu His Asp Ala Pro Arg Phe Asp Cys Thr <210> 122 <211> 1760 <212> DNA
<213> AsGV
<400> 122 atgaccagaa tcgcgttact gtctctcttt ttgctaatca ccacaacact tgctaaacct 60 1308 SEQ.LISTING.txt ggtgtgccca caattagatg gggtaattat aagtacagtc tagttgaatt aaatccagag 120 gcggtttcat acgaaagtct tattaagcaa atacacaata gtgttcaaat tagtgtagca 180 tgggatgtat ggtacggttc tgatggtgat cgagttgagc tcctgtttaa taacaacgta 240 gtaaagactg gtggaaaaga tgaagttagt aaaaaagaga ttgtcgtgga agttttgaaa 300 ggtggaacat attcagccgt cgtaaaactt tgcgacacca ccgactgttc tgttagcgcc 360 ccggtaaaaa ttgttgtagc cgacacggac ggttcccact tggaacccat cgaatacgtg 420 tggcgggaca acaacaaacc atacactaga gcgacggatc atgtggtggc cggttacttt 480 gtagagtggg gtgtttacga cagacaatat ccagcagact tagttcccgt ccccaacctt 540 acgcatcttt tgtatggctt tgtgcctctc tgcggtggag atggtataaa cgatagctta 600 aagcaagtgc cgggttcgtt tgaggcttta caaaaatctt gcgcgggtcg agaggatttt 660 aaagtgacga ttcacgatat ttggggcgct cttcaaaaac cacaaaaagg agtgggcgct 720 tgggacgatc cgtataaagg aaattttggc caactgatgg cgattaaaag acacaatccc 780 gaccttacga ttttaccgtc tattggcggg tggacactta gcgacccttt ctttaaattg 840 agttctgccg aaaatcgcgc cgttttcgtt gagtccgcac gagagtattt gcgcacatgg 900 aaattttttg acggactaga catcgactgg gagtttccgg gcggtaaagg tgctaatccc 960 gaattaggag atccagaaaa ggatggagta acatatgtgc agttattgaa agagctcaga 1020 gaaatgctaa acgatctttc taaagaaaca gggaaaaaat accagctcac ctcggcgatt 1080 agcgcggggt acgataaaat ctctatagtt aattatgaaa atgcgcaaga gtatcttgat 1140 cacatttttg ttatgacgta cgattttaaa ggcgcttggt ctaacacgga cttgggatat 1200 cacactacac tttattcacc ctcttggaac gctgaagaaa aatatactgc cgagtacgcg 1260 acaaaggagt tgttaaaaca aaacgtcaat agtaagaaaa tagtgctagc tgttgcaatg 1320 tacggaagag ggtggacggg tgtgcatgac ataaaaaaca acaatccctt tacgggtgta 1380 gctcaggggc cgattaaagg aacttgggaa agtggagttg tagattacaa agatttgata 1440 caaaggtaca ccgacactta ttatgactct gtagcgcaag cggcatatgc gttcgcagag 1500 aatgttggtg atctacttac ttacgataac ccaacgagtg tgcaagctaa gggaaagttt 1560 gtaatagaca acaatttggg tggtttgttt gcgtgggaac tggacgccga caatggcgac 1620 attcttaaca gcatgaacga gggtttaggt aataaaccac taccggtgct aaaacttaat 1680 ttaacccaaa agacttatgt acaatacatt tgtcctttta aaaatgccat tagttacgca 1740 ttagattata tatgttagct 1760 <210> 123 <211> 585 <212> PRT
<213> AsGV
<400> 123 Met Thr Arg Ile Ala Leu Leu Ser Leu Phe Leu Leu Ile Thr Thr Thr Leu Ala Lys Pro Gly Val Pro Thr Ile Arg Trp Gly Asn Tyr Lys Tyr Ser Leu Val Glu Leu Asn Pro Glu Ala Val Ser Tyr Glu Ser Leu Ile Lys Gln Ile His Asn Ser Val Gln Ile Ser Val Ala Trp Asp Val Trp Tyr Gly Ser Asp Gly Asp Arg Val Glu Leu Leu Phe Asn Asn Asn Val Val Lys Thr Gly Gly Lys Asp Glu Val Ser Lys Lys Glu Ile Val Val SEQ.LISTING.txt GluVal Leu Lys Gly Gly Thr Tyr Ser Ala Val Val Lys Leu Cys Asp ThrThr Asp Cys Ser Val Ser Ala Pro Val Lys Ile Val Val Ala Asp ThrAsp Gly Ser His Leu Glu Pro Ile Glu Tyr Val Trp Arg Asp Asn AsnLys Pro Tyr Thr Arg Ala Thr Asp His Val Val Ala Gly Tyr Phe ValGlu Trp Gly Val Tyr Asp Arg Gln Tyr Pro Ala Asp Leu Val Pro ValPro Asn Leu Thr His Leu Leu Tyr Gly Phe Val Pro Leu Cys Gly GlyAsp Gly Ile Asn Asp Ser Leu Lys Gln Val Pro Gly Ser Phe Glu AlaLeu Gln Lys Ser Cys Ala Gly Arg Glu Asp Phe Lys Val Thr Ile HisAsp Ile Trp Gly Ala Leu Gln Lys Pro Gln Lys Gly Val Gly Ala TrpAsp Asp Pro Tyr Lys Gly Asn Phe Gly Gln Leu Met Ala Ile Lys ArgHis Asn Pro Asp Leu Thr Ile Leu Pro Ser Ile Gly Gly Trp Thr LeuSer Asp Pro Phe Phe Lys Leu Ser Ser Ala Glu Asn Arg Ala Val PheVal Glu Ser Ala Arg Glu Tyr Leu Arg Thr Trp Lys Phe Phe Asp GlyLeu Asp Ile Asp Trp Glu Phe Pro Gly Gly Lys Gly Ala Asn Pro GluLeu Gly Asp Pro Glu Lys Asp Gly Val Thr Tyr Val Gln Leu Leu LysGlu Leu Arg Glu Met Leu Asn Asp Leu Ser Lys Glu Thr Gly Lys LysTyr Gln Leu Thr Ser Ala Ile Ser Ala Gly Tyr Asp Lys Ile Ser IleVal Asn Tyr Glu Asn Ala Gln Glu Tyr Leu Asp His Ile Phe Val MetThr Tyr Asp Phe Lys Gly Ala Trp Ser Asn Thr Asp Leu Gly Tyr HisThr Thr Lys Pro Ser Trp Asn Ala Glu Glu Lys Tyr Thr Ala Glu TyrAla Thr Lys Glu Leu Leu Lys Gln Asn Val Asn Ser Lys Lys Ile ValLeu Ala Val Ala Met Tyr Gly Arg Gly Trp Thr Gly Val His Asp IleLys Asn Asn Asn Pro Phe Thr Gly Val Ala Gln Gly Pro Ile Lys GlyThr Trp Glu Ser Gly Val Val Asp Tyr Lys Asp Leu Ile Gln Arg 1308 SEQ.LISTING.txt Tyr Thr Asp Thr Tyr Tyr Asp Ser Val Ala Gln Ala Ala Tyr Ala Phe Ala Glu Asn Val Gly Asp Leu Leu Thr Tyr Asp Asn Pro Thr Ser Val Gln Ala Lys Gly Lys Phe Val Ile Asp Asn Asn Leu Gly Gly Leu Phe Ala Trp Glu Leu Asp Ala Asp Asn Gly Asp Ile Leu Asn Ser Met Asn Glu Gly Leu Gly Asn Lys Pro Leu Pro Val Leu Lys Leu Asn Leu Thr Gln Lys Thr Tyr Val Gln Tyr Ile Cys Pro Phe Lys Asn Ala Ile Ser Tyr Ala Leu Asp Tyr Ile Cys Cys Thr <210> 124 <211> 557 <212> DNA
<213> AsGV
<400> 124 atgctgtcca taatgcttca gaatcaccaa gttttctacg gcttcgatgg attgctgcaa 60 ttaatgatta attataattt tacgagaata cacaagggta atttagaatg tgataagttg 120 tgtatcgtag gtgaaaatga acaagtattt gtaacagacg gtgttaatat ggacgtaagg 180 cgcgttgtcc acgatgaatg ctttatcagc ttcgaagcag tatttgagat tattgataca 240 aacatgttag gcgacaagta taccgtagag aagattattg tggaatgtac taagagagta 300 gtaaaaagtg acgtttggta taaaaaatat ttggtaatat taaaaaaacg cgttaacgcc 360 tcttttgatg tatactttaa agtattagaa cagtatatgc tgttaaatca acctaatgct 420 gaacgaatag gcaaaaaggt ctctaatcta attaaaatgg ctgaagcgtt aaagcattcc 480 gaccaagccc aagaactgat aactgcatat caatcttttg aaacggcaag cgctatctta 540 ctaaagcaat tataact 557 <210> 125 <211> 186 <212> PRT
<213> AsGV
<400> 125 Met Leu Ser Ile Met Leu Gln Asn His Gln Val Phe Tyr Gly Phe Asp Gly Leu Leu Gln Leu Met Ile Asn Tyr Asn Phe Thr Arg Ile His Lys Gly Asn Leu Glu Cys Asp Lys Leu Cys Ile Val Gly Glu Asn Glu Gln Val Phe Val Thr Asp Gly Val Asn Met Asp Val Arg Arg Val Val His Asp Glu Cys Phe Ile Ser Phe Glu Ala Val Phe Glu Ile Ile Asp Thr 1308 SEQ.LISTING.txt Asn Met Leu Gly Asp Lys Tyr Thr Val Glu Lys Ile Ile Val Glu Cys Thr Lys Arg Val Val Lys Ser Asp Val Trp Tyr Lys Lys Tyr Leu Val Ile Leu Lys Lys Arg Val Asn Ala Ser Phe Asp Val Tyr Phe Lys Val Leu Glu Gln Tyr Met Leu Leu Asn Gln Pro Asn Ala Glu Arg Ile Gly Lys Lys Val Ser Asn Leu Ile Lys Met Ala Glu Ala Leu Lys His Ser Asp Gln Ala Gln Glu Leu Ile Thr Ala Tyr Gln Ser Phe Glu Thr Ala Ser Ala Ile Leu Leu Lys Gln Leu Cys Thr <210> 126 <211> 431 <212> DNA
<213> AsGV
<400> 126 atggatctta aaacactgtt actttttcaa tggaacacgc ctcctacaaa aaacgtgcct 60 cggcgttacg aatatacgcc ttcacgagtt tattattcgt ttggaaaaca ccaccgcata 120 tacgaccact ggtattcgtg cgtaaagagc gtctttacac tttcgcaaga aactcgtgac 180 tttttacaag tgtttaataa tcgagcccag agagacgact ggtcttatat tgaagtgaga 240 aagctgcttc gggatgttga ctataaagaa attgaagagt gctattgtct atgggcgtat 300 gttactaaag acggaatgcc cggctgcgaa agggttatgg aaaaaattat tgaagattgc 360 gccagcggtt tggtgtttgt caccgatgag tgtgtgacgc aggagactga caaatatttg 420 tggtattgac t 431 <210> 127 <211> 144 <212> PRT
<213> AsGV
<400> 127 Met Asp Leu Lys Thr Leu Leu Leu Phe Gln Trp Asn Thr Pro Pro Thr Lys Asn Val Pro Arg Arg Tyr Glu Tyr Thr Pro Ser Arg Val Tyr Tyr Ser Phe Gly Lys His His Arg Ile Tyr Asp His Trp Tyr Ser Cys Val Lys Ser Val Phe Thr Leu Ser Gln Glu Thr Arg Asp Phe Leu Gln Val Phe Asn Asn Arg Ala Gln Arg Asp Asp Trp Ser Tyr Ile Glu Val Arg 1308 SEQ.LISTING.txt Lys Leu Leu Arg Asp Val Asp Tyr Lys Glu Ile Glu Glu Cys Tyr Cys Leu Trp Ala Tyr Val Thr Lys Asp Gly Met Pro Gly Cys Glu Arg Val Met Glu Lys Ile Ile.Glu Asp Cys Ala Ser Gly Leu Val Phe Val Thr Asp Glu Cys Val Thr Gln Glu Thr Asp Lys Tyr Leu Trp Tyr Cys Thr <210> 128 <211> 512 <212> DNA
<213> AsGV
<400> 128 atgaaccaag aggaaatgga ggagaaaaga gcccgacttc tttttgaaaa gaacaatatt 60 ttagattgta gcaacacatc cattcatgta ccttgcgtga ccgatagaca atgtcaagag 120 aattgtagaa gcggaattct gtttacttgt atagcaggct tctgtcaggt ggaattgcaa 180 gctgtcgaca ctattgagcc cgcagattgt gatgcagaac gtggtcaaat tgttgtattg 240 aatgcgctcg acagtcttgt cgtagactat ttttgcataa gcctgtaccg tgacgtaatc 300 gaagatggtg gtaacctgag aaattatgtg tgtgacggtg gggaaatgta tattaattta 360 gaagaaggtc cgtttcaggt gagcgattgc aaatgtccag aagaacacac tagattaact 420 tatcgacctg gcgcgtttca tcgcgacact cctgtgtgca ttcgtaatag accagcaatt 480 ttgtactctc gtgtatacgg gacctcatga ct 512 <210> 129 <211> 167 <212> PRT
<213> AsGV
<400> 129 Met Asn Gln Glu Glu Met Glu Glu Lys Arg Ala Arg Leu Leu Phe Glu Lys Asn Asn Ile Leu Asp Cys Ser Asn Thr Ser Ile His Val Pro Cys Val Thr Asp Arg Gln Cys Gln Glu Asn Cys Arg Ser Gly Ile Leu Phe Thr Cys Ile Ala Gly Phe Cys Gln Val Glu Leu Gln Ala Val Asp Thr Ile Glu Pro Ala Asp Cys Asp Ala Glu Arg Gly Gln Ile Val Val Leu Asn Ala Leu Asp Ser Leu Val Val Asp Tyr Phe Cys Ile Ser Leu Tyr Arg Asp Val Ile Glu Asp Gly Gly Asn Leu Arg Asn Tyr Val Cys Asp Gly Gly Glu Met Tyr Ile Asn Leu Glu Glu Gly Pro Phe Gln Val Ser 1308 SEQ.LISTING.txt AspCys Lys Cys Pro Glu Glu His Thr Arg Leu Tyr Pro Gly Ala Phe HisArg Asp Thr Pro Val Cys Ile Arg Asn Arg Pro Ala Ile Lys Arg ValTyr Gly Thr Ser Cys Thr <210> 130 <211> 725 <212> DNA
<213> AsGV
<400> 130 atgtgtgaag acgagagctt gtgtgatttg ttattggatt tggacacaaa tttggttcat 60 tatgaagatc cgcttattac tctacaagaa caaatcgctt ctttaaaaca aattatacga 120 gacaaggacg cttgcatatc tgaatatgaa caacggttaa aactttttga agatttattt 180 aaaaaggaag aagacttaat taaaaaggaa gacaattatt gtaacgaaga ttcaattaaa 240 aagaaagatg tttctaataa aaaggattgt tgcaaaaaaa taaaatgtgt gaaagctatg 300 cataaactgc gagcaaacgc ctccaagatt aacagtttag aaaaaaaaat tgaagaaaat 360 ctgcagctac acagagatca cgttaaggga tataatgaac tctttcaaac acatgaatta 420 tttaaaaaag aaacaaccaa acttatagaa tctttgaaag aggacgcact aaaactacaa 480 aacaacaacg aaaagttgac taatgacctt gtttcaatta tgaagaagag agatgacata 540 aacagactta aagataaatt atataacact tctcgggaaa accacaaaat gaagtgtaaa 600 atacagtggt ataaaacaga gttgagtaat gtgtacaaga agtgcaacaa agctatagaa 660 tgcgctaaaa actatgaaac aatatttaac accagtgtaa aaactgttcc aataacgcag 720 tagct 725 <210> 131 <211> 242 <212> PRT
<213> AsGV
<400> 131 Met Cys Glu Asp Glu Ser Leu Cys Asp Leu Leu Leu Asp Leu Asp Thr Asn Leu Val His Tyr Glu Asp Pro Leu Ile Thr Leu Gln Glu Gln Ile Ala Ser Leu Lys Gln Ile Ile Arg Asp Lys Asp Ala Cys Ile Ser Glu Tyr Glu Gln Arg Leu Lys Leu Phe Glu Asp Leu Phe Lys Lys Glu Glu Asp Leu Ile Lys Lys Glu Asp Asn Tyr Cys Asn Glu Asp Ser Ile Lys Lys Lys Asp Val Ser Asn Lys Lys Asp Cys Cys Lys Lys Ile Lys Cys Val Lys Ala Met His Lys Leu Arg Ala Asn Ala Ser Lys Ile Asn Ser 1308 SEQ.LISTING.txt Leu Glu Lys Lys Ile Glu Glu Asn Leu Gln Leu His Arg Asp His Val Lys Gly Tyr Asn Glu Leu Phe Gln Thr His Glu Leu Phe Lys Lys Glu Thr Thr Lys Leu Ile Glu Ser Leu Lys Glu Asp Ala Leu Lys Leu Gln Asn Asn Asn Glu Lys Leu Thr Asn Asp Leu Val Ser Ile Met Lys Lys Arg Asp Asp Ile Asn Arg Leu Lys Asp Lys Leu Tyr Asn Thr Ser Arg Glu Asn His Lys Met Lys Cys Lys Ile Gln Trp Tyr Lys Thr Glu Leu Ser Asn Val Tyr Lys Lys Cys Asn Lys Ala Ile Glu Cys Ala Lys Asn Tyr Glu Thr Ile Phe Asn Thr Ser Val Lys Thr Val Pro Ile Thr Gln Cys Thr <210> 132 <211> 1292 <212> DNA
<213> AsGV
<400> 132 atgttgctac aaaaggttgt gtgcgcttca agaaaggagg gagaggggaa aatagctgtt 60 tacgttgtga cgggcgataa tcaaatatat tactgtaaag aaacgttcac tcaacacctt 120 aaagacaatg tgggactgat tgaaacaaaa tacgtgaaac gattcgatca atttgaagac 180 cttatgtttc aagtaaacgt gcatatagac gctgatgccg aatttatcaa cgaaccgggt 240 gtgtatcaat tgttgttggg tggaggacaa ttgggcaatt tggaaaccaa taaggatttt 300 atagactggg tctttaaaga acttttaccc actgtaaaga tgacggtttt cttcagaaac 360 aacactgcca ccatagacac ggtgccgttc aataatcatc tttgcatgga caacttaatt 420 gcaattataa aacaacgcga cgcgcttgtc gctaaaaaag ataaacaaat tgatgcgatg 480 ctgaatacgg ttcaacaaca actaatattg ttgagtgcaa taagagacgt gaacaaaaca 540 cgttttgatc aaatagatag caccattgca aagatgggac aaagtgtgca gcaaaagatt 600 gccgagttaa aattattagt ttctcaatgc gccaatcaag taatagaaat tgttgatgat 660 gacgaagagg agaatcaaat tcatttacaa gagactcaaa taatacctga tcttcatttg 720 atggacacgc aaatcatacc ttcggcggtg gcagagtcgc aagaaaagtt tataaattat 780 gaagagaaga acgaaaatag ccaaccggcg gctgagagct caccatccat tttgagatca 840 caagattcgc tgccgccaaa ttatgaaata tataatgaac tggataaatg gtacgagatt 900 acgagtcaaa caaatttagc aagtcaaatg acgagtcgta cggataacag aaagtttata 960 gaaaagcgta acaagacgtc ctcccgatac ggagttcttt tgtacaggga agatggtgct 1020 gcgattgccg ctgtgatggg tcaaatgcac tatgtgttgg cgcaaatgaa aaataaaaat 1080 catatcgcta acaatctgat tgtgttgttc tgcgtagagg atccgcaaaa gcattggttg 1140 ttaattagac aattaatgtt aagcgaggga agatttatac accgcatgac taacagaaaa 1200 atttatttta gtactgtcac tgaagccgac gagtttgaaa atttgataaa gtgcaagttt 1260 ccagaacaac aaataaagat gattgtgtaa ct 1292 1308 SEQ.LISTING.txt <210> 133 <211> 431 <212> PRT
<213> AsGV
<400> 133 Met Leu Leu Gln Lys Val Val Cys Ala Ser Arg Lys Glu Gly Glu Gly Lys Ile Ala Val Tyr Val Val Thr Gly Asp Asn Gln Ile Tyr Tyr Cys Lys Glu Thr Phe Thr Gln His Leu Lys Asp Asn Val Gly Leu Ile Glu Thr Lys Tyr Val Lys Arg Phe Asp Gln Phe Glu Asp Leu Met Phe Gln Val Asn Val His Ile Asp Ala Asp Ala Glu Phe Ile Asn Glu Pro Gly Val Tyr Gln Leu Leu Leu Gly Gly Gly Gln Leu Gly Asn Leu Glu Thr Asn Lys Asp Phe Ile Asp Trp Val Phe Lys Glu Leu Leu Pro Thr Val Lys Met Thr Val Phe Phe Arg Asn Asn Thr Ala Thr Ile Asp Thr Val Pro Phe Asn Asn His Leu Cys Met Asp Asn Leu Ile Ala Ile Ile Lys Gln Arg Asp Ala Leu Val Ala Lys Lys Asp Lys Gln Ile Asp Ala Met Leu Asn Thr Val Gln Gln Gln Leu Ile Leu Leu Ser Ala Ile Arg Asp Val Asn Lys Thr Arg Phe Asp Gln Ile Asp Ser Thr Ile Ala Lys Met Gly Gln Ser Val Gln Gln Lys Ile Ala Glu Leu Lys Leu Leu Val Ser Gln Cys Ala Asn Gln Val Ile Glu Ile Val Asp Asp Asp Glu Glu Glu Asn Gln Ile His Leu Gln Glu Thr Gln Ile Ile Pro Asp Leu His Leu Met Asp Thr Gln Ile Ile Pro Ser Ala Val Ala Glu Ser Gln Glu Lys Phe Ile Asn Tyr Glu Glu Lys Asn Glu Asn Ser Gln Pro Ala Ala Glu Ser Ser Pro Ser Ile Leu Arg Ser Gln Asp Ser Leu Pro Pro Asn Tyr Glu Ile Tyr Asn Glu Leu Asp Lys Trp Tyr Glu Ile Thr Ser Gln Thr Asn Leu Ala Ser Gln Met Thr Ser Arg Thr Asp Asn Arg Lys Phe Ile Glu Lys Arg Asn Lys Thr Ser Ser Arg Tyr Gly Val Leu Leu Tyr Arg 1308 SEQ.LISTING.txt Glu Asp Gly Ala Ala Ile Ala Ala Val Met Gly Gln Met His Tyr Val Leu Ala Gln Met Lys Asn Lys Asn His Ile Ala Asn Asn Leu Ile Val Leu Phe Cys Val Glu Asp Pro Gln Lys His Trp Leu Leu Ile Arg Gln Leu Met Leu Ser Glu Gly Arg Phe Ile His Arg Met Thr Asn Arg Lys Ile Tyr Phe Ser Thr Val Thr Glu Ala Asp Glu Phe Glu Asn Leu Ile Lys Cys Lys Phe Pro Glu Gln Gln Ile Lys Met Ile Val Cys Thr <210> 134 <211> 1799 <212> DNA
<213> AsGV
<400> 134 atgtttcgtt taattctttg tgtaattttt attttctctt tcgttgaggg tggcggtgat 60 ggtattgttg atgatgaaat aaataaatat attaaaaacc aagactttaa tgttagcggt 120 tttcattacg aatttcaaaa caatttgggc tttgttgtaa atagttggaa ttttatttta 180 aatgtaaatt ataatgttct aaaggacagg cttaaacaat tggaggaatt atgttcttct 240 ttgcttcaaa aaatggacag tggaaaggag ttacacgatt gcgcgtttaa tgacgcgggt 300 ggatatgaac gggaattgaa gtacattaaa gaaagaaaaa ttttaaattt gtacgaagcg 360 cacgacagta taaagtttct attagtgcac aaaaaaattg gcactaaaag aaaaagacga 420 agccttttcg gaggagcttt caattttgta ggacgttttt acaaatactc aataggattg 480 atggacgata acgacgcggc ccttctttat gaggtagcca agcatgaaaa cagcaccgac 540 tacagagtta aagtactaac taacgaaact ctttctatta cggagtatct caatagcgta 600 aagcataaca tagaaaacgt cgtgagctgc cactttttag agcgccaatt agtttacata 660 aaggacaact tggaagagat tgaaactacc tacagcaaaa ttctcaccgc cgtacaatta 720 tcgctttata gcggtcgtct ttccactttt atcattagcc cacaattagt tttagacgaa 780 atggtacagg tagacaaaca aagtcttgat agggaaactg agtggattag cgatcctgta 840 atagagaaaa tgcatactat tatgcatgtt acacactgta gtgtttttat taatcctgac 900 gatgaactca tgtttgtgct gcagatacct agaatggaca agacaaaatt tgaactgtac 960 aaagtggttc ctgttccgca atgtaacggt aaacgaattt gtaaatttct ttccgctcaa 1020 tctcagtaca taggttttga aaaaaaacaa atgtattaca cacgcttaga cgacaccagt 1080 acatgtactg tattagaaaa tttaacattg tgttttggtt cgatgacgag caaatacatt 1140 tcatacacta acgactgtga cgttaaaatg ttttacaata tggatgtgcg tagcaaatgc 1200 gaggtgcacg cttcgaaatt ttacagcgaa atcttttata gtcttaacaa tgtcaataaa 1260 tggctgtata tggtagaaaa acctatactt gtacagctca attgtggtac gggaagtttc 1320 gagctaaaaa caaggataaa cggaaccgga ataattacgc ttttacaata ttgtaaattg 1380 aaaacaagca gatcggtttt ggtttccaaa cacgtgcagc ttgatgaaag taaatttaaa 1440 gttattcagt ttaactttag taaattttat ttaccaccca attacaacag caacggaaaa 1500 attataaaga gtttggatca cgaaagtctt agcgaaatta cgcacactct acagcgttta 1560 gttacaaacg aagaagcaca aaaagcatta gatattaaag aattggatga taattctaat 1620 1308 SEQ.LISTING.txt tcaaactggt acctaaactt gttcggaaat tggtggtggg aagtcaagtt tgttgtatac 1680 attattttag gaattttgtt tacgatgata cttttatatt ttaaaagaaa ttgcggctgc 1740 tgctgcactt acaacaatag agatgtaatg ttaccaattt tcagcccaaa gtattaact 1799 <210> 135 <211> 598 <212> PRT
<213> AsGV
<400> 135 Met Phe Arg Leu Ile Leu Cys Val Ile Phe Ile Phe Ser Phe Val Glu Gly Gly Gly Asp Gly Ile Val Asp Asp Glu Ile Asn Lys Tyr Ile Lys Asn Gln Asp Phe Asn Val Ser Gly Phe His Tyr Glu Phe Gln Asn Asn Leu Gly Phe Val Val Asn Ser Trp Asn Phe Ile Leu Asn Val Asn Tyr Asn Val Leu Lys Asp Arg Leu Lys Gln Leu Glu Glu Leu Cys Ser Ser Leu Leu Gln Lys Met Asp Ser Gly Lys Glu Leu His Asp Cys Ala Phe Asn Asp Ala Gly Gly Tyr Glu Arg Glu Leu Lys Tyr Ile Lys Glu Arg Lys Ile Leu Asn Leu Tyr Glu Ala His Asp Ser Ile Lys Phe Leu Leu Val His Lys Lys Ile Gly Thr Lys Arg Lys Arg Arg Ser Leu Phe Gly Gly Ala Phe Asn Phe Val Gly Arg Phe Tyr Lys Tyr Ser Ile Gly Leu Met Asp Asp Asn Asp Ala Ala Leu Leu Tyr Glu Val Ala Lys His Glu Asn Ser Thr Asp Tyr Arg Val Lys Val Leu Thr Asn Glu Thr Leu Ser Ile Thr Glu Tyr Leu Asn Ser Val Lys His Asn Ile Glu Asn Val Val Ser Cys His Phe Leu Glu Arg Gln Leu Val Tyr Ile Lys Asp Asn Leu Glu Glu Ile Glu Thr Thr Tyr Ser Lys Ile Leu Thr Ala Val Gln Leu Ser Lys Gly Arg Leu Ser Thr Phe Ile Ile Ser Pro Gln Leu Val Leu Asp Glu Met Val Gln Val Asp Lys Gln Ser Leu Asp Arg Glu Thr Glu Trp Ile Ser Asp Pro Val Ile Glu Lys Met His Thr Ile Met His Val Thr His Cys Ser Val Phe Ile Asn Pro Asp Asp Glu Leu Met Phe Val 1308 SEQ.LISTING.txt Leu Gln Ile Pro Arg Met Asp Lys Thr Lys Phe Glu Leu Tyr Lys Val Val Pro Val Pro Gln Cys Asn Gly Lys Arg Ile Cys Lys Phe Leu Ser Ala Gln Ser Gln Tyr Ile Gly Phe Glu Lys Lys Gln Met Tyr Tyr Thr Arg Leu Asp Asp Thr Ser Thr Cys Thr Val Leu Glu Asn Leu Thr Leu Cys Phe Gly Ser Met Thr Ser Lys Tyr Ile Ser Tyr Thr Asn Asp Cys Asp Val Lys Met Phe Tyr Asn Met Asp Val Arg Ser Lys Cys Glu Val His Ala Ser Lys Phe Tyr Ser Glu Ile Phe Tyr Ser Leu Asn Asn Val Asn Lys Trp Leu Tyr Met Val Glu Lys Pro Ile Leu Val Gln Leu Asn Cys Gly Thr Gly Ser Phe Glu Leu Lys Thr Arg Ile Asn Gly Thr Gly Ile Ile Thr Leu Leu Gln Tyr Cys Lys Leu Lys Thr Ser Arg Ser Val Leu Val Ser Lys His Val Gln Leu Asp Glu Ser Lys Phe Lys Val Ile Gln Phe Asn Phe Ser Lys Phe Tyr Leu Pro Pro Asn Tyr Asn Ser Asn Gly Lys Ile Ile Lys Ser Leu Asp His Glu Ser Leu Ser Glu Ile Thr His Thr Leu Gln Arg Leu Val Thr Asn Glu Glu Ala Gln Lys Ala Leu Asp Ile Lys Glu Leu Asp Asp Asn Ser Asn Ser Asn Trp Tyr Leu Asn Leu Phe Gly Asn Trp Trp Trp Glu Val Lys Phe Val Val Tyr Ile Ile Leu Gly Ile Leu Phe Thr Met Ile Leu Leu Tyr Phe Lys Arg Asn Cys Gly Cys Cys Cys Thr Tyr Asn Asn Arg Asp Val Met Leu Pro Ile Phe Ser Pro Lys Tyr Cys Thr <210> 136 <211> 896 <212> DNA
<213> AsGV
<400> 136 atggagtgga tcgttttgcg caataagtgg gcctccgtta agggacatgt cttaatattg 60 aatcgctact cagatgtacg ctttgcagaa atgtgcgcac ttgacaaaat agaatttgta 120 1308 SEQ.LISTING.txt gtcttcgccg acgacgttgt ccgacacaac ttctcaccaa tttacaaaat ggatacaata 180 acttctctcg atagcgtgac cgactttcga aatcaactta aaaataaata tcaaatctcc 240 tatctcggcc atttattcac cacttatgag agtccggcaa catacaagtt tttagaagaa 300 tggctactgt taaatgtaaa cgaagtgaat catttaaaca gcacgcaaat gttttctcct 360 ccccacgtta ttgtattcga tatggactca actcttataa cagaagagga ggaggtgcgc 420 ctgcgcgatc cctttataca cgaaagtttg gattttttaa aaagaaataa ttgcgttctt 480 tgtttgtgga gctacggtga aaggcgtcat gtggtggaga gtttgaaaaa attaaacttg 540 tacgattact ttttagttgt tttatccgaa ggtagaaagt taggcgatta ccactttgaa 600 gacggtttag acacacgcta cgaaatagta tataaaagca caccgtttta tcttaacgtt 660 caaccccaca accttccgaa atctcctcgc gtcattttgc attatctcaa agaaaaagga 720 attaatttta taaaaaccat aacgttagtg gatgacttgc accacaataa tattcattat 780 gataatttcg ttaatttaac tcgttgtccc gaaccagtcc aagactggca cgtgtggcac 840 tctgagattg tgcgttatct taaagaatac gattgcttcc atggcgactc gtaact 896 <210> 137 <211> 299 <212> PRT
<213> AsGV
<400> 137 Met Glu Trp Ile Val Leu Arg Asn Lys Trp Ala Ser Val Lys Gly His Val Leu Ile Leu Asn Arg Tyr Ser Asp Val Arg Phe Ala Glu Met Cys Ala Leu Asp Lys Ile Glu Phe Val Val Phe Ala Asp Asp Val Val Arg His Asn Phe Ser Pro Ile Tyr Lys Met Asp Thr Ile Thr Ser Leu Asp Ser Val Thr Asp Phe Arg Asn Gln Leu Lys Asn Lys Tyr Gln Ile Ser Tyr Leu Gly His Leu Phe Thr Thr Tyr Glu Ser Pro Ala Thr Tyr Lys Phe Leu Glu Glu Trp Leu Leu Leu Asn Val Asn Glu Val Asn His Leu Asn Ser Thr Gln Met Phe Ser Pro Pro His Val Ile Val Phe Asp Met Asp Ser Thr Leu Ile Thr Glu Glu Glu Glu Val Arg Leu Arg Asp Pro Phe Ile His Glu Ser Leu Asp Phe Leu Lys Arg Asn Asn Cys Val Leu Cys Leu Trp Ser Tyr Gly Glu Arg Arg His Val Val Glu Ser Leu Lys Lys Leu Asn Leu Tyr Asp Tyr Phe Leu Val Val Leu Ser Glu Gly Arg Lys Leu Gly Asp Tyr His Phe Glu Asp Gly Leu Asp Thr Arg Tyr Glu Ile Val Tyr Lys Ser Thr Pro Phe Tyr Leu Asn Val Gln Pro His Asn 1308 SEQ.LISTING.txt Leu Pro Lys Ser Pro Arg Val Ile Leu His Tyr Leu Lys Glu Lys Gly Ile Asn Phe Ile Lys Thr Ile Thr Leu Val Asp Asp Leu His His Asn Asn Ile His Tyr Asp Asn Phe Val Asn Leu Thr Arg Cys Pro Glu Pro Val Gln Asp Trp His Val Trp His Ser Glu Ile Val Arg Tyr Leu Lys Glu Tyr Asp Cys Phe His Gly Asp Ser Cys Thr <210> 138 <211> 1577 <212> DNA
<213> AsGV
<400> 138 atggtttaca ttaagattga tattggtagt cacacaaagg ggtattccac caatactagc 60 gaccgtgatt atataatttt ttcaaaatgt gacgcttata cttttttgga ccatatctct 120 gagaaaaaaa ggctggtcaa cgttcacaaa aaagacgaag aagggaatga ttgcgtttac 180 gtggatctat acaaaggttt acaaggtatt tacactggca aatattatta cttaggtgta 240 tttgcaaagc agagtgatgt taaagacaaa aatggttggg aaaatgtgaa cttgtttgaa 300 tttattcaag acctaaccaa gctgcgtata catttgattt tgaaaacgat ggtaaaatat 360 agagtaaaaa cttccctgac cgatcaaccc aagcaactgt tggccattat gtttaatttg 420 gcctacattg aacattggtt aaagtataat acatttcctg aggtcaacaa attgccaaat 480 ttattgtacg atgaagaaaa acctctgcgc tactacaaga gtttgatgaa agcgcgcgtt 540 gagaacactg taactacact ttccgaagag gttgattaca ttaaaaattg gcaagatgcg 600 gtagaggtaa aattagagtc gttcggcaca cccctggaga gatatgatat tcaaaggaac 660 attgtaatgt acatgttaaa tgcgggtagt ctacagggtt tttgtgaaga taccatcaaa 720 aactgcatct ttccatcgat tcaacagctg tcgagaacga agaatggtaa ccttttcgga 780 aggactgtga ctgtccagga aaaattggac gggtgcaatt ttagagttat agtcgatcgg 840 gacctaatca cgtatggctc aaggaacacc tattattcta ctcgtgattt catggggttt 900 tatagaatta aaaactcttt ggaaaaatct gccataaagt tgaaaggaat actaaagtta 960 aatcagtttg ttatttacgg cgagctgatt ggttggtgtt tttcaaatga taaactattg 1020 tatgagacaa tcggacaaga gatcgattac aaactaccat acggcaccat aaagtattat 1080 gcttatgaaa ttcgtaaata cgacggctac aacaacgatt ttttggactt tgaaatgagc 1140 caaaaatggc tgcaggaggc tggttttgat atcataccct atgataaaat cttttatgat 1200 tacttcattg aaaatatcaa gttttcttcc aagctttttt ctcaaaactc cattgaaggt 1260 tatataattc gctgtggtcc tctgagatat aaagtaaaag aacattattg tttgggagat 1320 ttacgaaacg ctttacatca gattaataat acatttgtta atagcgtatt aggagaggaa 1380 gagggtaaat tggaattaca cgagcttgta tttgccgcaa aaaaatgtta cgacacgctg 1440 atgcctgtcg ataaggatat accgctctat aaaatttttg gtaaactcta cactttattg 1500 agacagagag ctcacattac tgatgatttg cattactcca aagcgtttga aatgtttcaa 1560 actttattag aataact 1577 <210> 139 <211> 524 <212> PRT
<213> AsGV
1308 SEQ.LISTING.txt <400> 139 Met Val Tyr Ile Lys Ile Asp Ile Gly Ser His Thr Lys Gly Tyr Ser Thr Asn Thr Ser Asp Arg Asp Tyr Ile Ile Phe Ser Lys Cys Asp Ala Tyr Thr Phe Leu Asp His Glu Lys Lys Arg Leu Val Asn Val His Lys Lys Asp Glu Glu Gly Asn Asp Cys Val Tyr Val Asp Leu Tyr Lys Gly Leu Gln Gly Ile Tyr Thr Gly Lys Tyr Tyr Tyr Leu Gly Val Phe Ala Lys Gln Ser Asp Val Lys Asp Lys Asn Gly Trp Glu Asn Val Asn Leu Phe Glu Phe Ile Gln Asp Leu Thr Lys Leu Arg Ile His Leu Ile Leu Lys Thr Met Val Lys Tyr Arg Val Lys Thr Ser Leu Thr Asp Gln Pro Lys Gln Leu Leu Ala Ile Met Phe Asn Leu Ala Tyr Ile Glu His~Trp Leu Lys Tyr Asn Thr Phe Pro Glu Val Asn Lys Leu Pro Asn Leu Leu Tyr Asp Glu Glu Lys Pro Leu Arg Tyr Tyr Lys Ser Leu Met Lys Ala Arg Val Glu Asn Thr Val Thr Thr Leu Ser Glu Glu Val Asp Tyr Ile Lys Asn Trp Gln Asp Ala Val Glu Val Lys Leu Glu Ser Phe Gly Thr Pro Leu Glu Arg Tyr Asp Ile Gln Arg Asn Ile Val Met Tyr Met Leu Asn Ala Gly Ser Leu Gln Gly Phe Cys Glu Asp Thr Ile Lys Asn Cys Ile Phe Pro Ser Ile Gln Gln Leu Ser Arg Thr Lys Asn Gly Asn Leu Phe Gly Arg Thr Val Thr Val Gln Glu Lys Leu Asp Gly Cys Asn Phe Arg Val Ile Val Asp Arg Asp Leu Ile Thr Tyr Gly Ser Arg Asn Thr Tyr Tyr Ser Thr Arg Asp Phe Met Gly Phe Tyr Arg Ile Lys Asn Ser Leu Glu Lys Ser Ala Ile Lys Leu Lys Gly Ile Leu Lys Leu Asn Gln Phe Val Ile Tyr Gly Glu Leu Ile Gly Trp Cys Phe Ser Asn Asp Lys Leu Leu Tyr Glu Thr Ile Gly Gln Glu Ile Asp Tyr Lys Leu Pro Tyr 1308 SEQ.LISTING.txt Gly Thr Ile Lys Tyr Tyr Ala Tyr Glu Ile Arg Lys Tyr Asp Gly Tyr Asn Asn Asp Phe Leu Asp Phe Glu Met Ser Gln Lys Trp Leu Gln Glu Ala Gly Phe Asp Ile Ile Pro Tyr Asp Lys Ile Phe Tyr Asp Tyr Phe Ile Glu Asn Ile Lys Phe Ser Ser Lys Leu Phe Ser Gln Asn Ser Ile Glu Gly Tyr Ile Ile Arg Cys Gly Pro Leu Arg Tyr Lys Val Lys Glu His Tyr Cys Leu Gly Asp Leu Arg Asn Ala Leu His Gln Ile Asn Asn Thr Phe Val Asn Ser Val Leu Gly Glu Glu Glu Gly Lys Leu Glu Leu His Glu Leu Val Phe Ala Ala Lys Lys Cys Tyr Asp Thr Leu Met Pro Val Asp Lys Asp Ile Pro Leu Tyr Lys Ile Phe Gly Lys Leu Tyr Thr Leu Leu Arg Gln Arg Ala His Ile Thr Asp Asp Leu His Tyr Ser Lys Ala Phe Glu Met Phe Gln Thr Leu Leu Glu Cys Thr <210> 140 <211> 1091 <212> DNA
<213> AsGV
<400> 140 atggacgttg ccgaacacga tcttcatttc tctgacgaag aaaatgaaga ggtgaacaag 60 atttttaaca gcaaaaccac caaacgtgtt acttttaaaa atgacgttga cgagtgtcat 120 aaagctgtga tctctattca agaagtgcca cataaaatta agaagcgacc aaaaccgttc 180 gtttcttcag aagaaaaggc agcgaagcgc agaagagatt cacaatatat tgcagaacag 240 gaatttgtag cggaggaaga acagtttgtt atgccgaatg ttaatgtacc acactcggag 300 gagatgcgac cgaattataa tatgttagac ccggagatgt ttgaagccga agtcaaaagg 360 gagaatcgtg ttgaaagtga tgacgatgaa aaattgaggg aaaaaacaaa cggaaacgat 420 gatgacaata gcagttcgtc atcagacgaa gaaagtgaag aagatgtaga ggttaaaaag 480 gaggaggtga caccgccacc aaaaagcaag aaacccaaca aagcgccggt gcgtttttat 540 attgaagact tgataaatcg cttggatgag attatagcag agccagcgat gctcacggag 600 aatattcgtt tgattaaaga gaaagtggaa caaatgacca ccattaggcg aatccaaaac 660 attgcgccga aaaaggaact aaaaagttat gtgcacattt atgttggaag agaggtgatt 720 ggctttttta ataattcata caaacaacca aagggtgtga aagccaacat tcacaacgaa 780 acattaaagc tagagcctgc ttttagtatt tgtgtaggct acaagagtca aaagcgtgca 840 aatccgctta taaagaagct taaggttatg ggtaaccaag acttgtttcg gttctccgag 900 acgccgaaaa agtatcgaca ctgtaagctg aacaaaatgt gggagtacat tgaaactatt 960 cataaatttt gcaccgcaca ggacttgagt ccttcaacgg acaatcttca ctcttgccat 1020 aagtttatac gttatttgat acaaaatcaa aatgaagaaa attgtacgtt gactgttgaa 1080 1308 SEQ.LISTING.txt aacgcatagc t 1091 <210> 141 <211> 364 <212> PRT
<213> AsGV
<400> 141 Met Asp Val Ala Glu His Asp Leu His Phe Ser Asp Glu Glu Asn Glu Glu Val Asn Lys Ile Phe Asn Ser Lys Thr Thr Lys Arg Val Thr Phe Lys Asn Asp Val Asp Glu Cys His Lys Ala Val Ile Ser Ile Gln Glu Val Pro His Lys Ile Lys Lys Arg Pro Lys Pro Phe Val Ser Ser Glu Glu Lys Ala Ala Lys Arg Arg Arg Asp Ser Gln Tyr Ile Ala Glu Gln Glu Phe Val Ala Glu Glu Glu Gln Phe Val Met Pro Asn Val Asn Val Pro His Ser Glu Glu Met Arg Pro Asn Tyr Asn Met Leu Asp Pro Glu Met Phe Glu Ala Glu Val Lys Arg Glu Asn Arg Val Glu Ser Asp Asp Asp Glu Lys Leu Arg Glu Lys Thr Asn Gly Asn Asp Asp Asp Asn Ser Ser Ser Ser Ser Asp Glu Glu Ser Glu Glu Asp Val Glu Val Lys Lys Glu Glu Val Thr Pro Pro Pro Lys Ser Lys Lys Pro Asn Lys Ala Pro Val Arg Phe Tyr Ile Glu Asp Leu Ile Asn Arg Leu Asp Glu Ile Ile Ala Glu Pro Ala Met Leu Thr Glu Asn Ile Arg Leu Ile Lys Glu Lys Val Glu Gln Met Thr Thr Ile Arg Arg Ile Gln Asn Ile Ala Pro Lys Lys Glu Leu Lys Ser Tyr Val His Ile Tyr Val Gly Arg Glu Val Ile Gly Phe Phe Asn Asn Ser Tyr Lys Gln Pro Lys Gly Val Lys Ala Asn Ile His Asn Glu Thr Leu Lys Leu Glu Pro Ala Phe Ser Ile Cys Val Gly Tyr Lys Ser Gln Lys Arg Ala Asn Pro Leu Ile Lys Lys Leu Lys Val Met Gly Asn Gln Asp Leu Phe Arg Phe Ser Glu Thr Pro Lys Lys Tyr Arg His Cys Lys Leu Asn Lys Met Trp Glu Tyr Ile Glu Thr Ile 1308 SEQ.LISTING.txt His Lys Phe Cys Thr Ala Gln Asp Leu Ser Pro Ser Thr Asp Asn Leu His Ser Cys His Lys Phe Ile Arg Tyr Leu Ile Gln Asn Gln Asn Glu Glu Asn Cys Thr Leu Thr Val Glu Asn Ala Cys Thr <210> 142 <211> 1124 <212> DNA
<213> AsGV
<400> 142 atgagtgcta aaacaagact ttttttgacg attgaaaaac ttaaaaatgc aatggacgac 60 gcgcaaatga ggtttccgtt ttgggaacaa ttctttcctt tacttggcga cgctaccact 120 atagatgttg atcttagcgt tctgagcgaa ctaattaacg aagcggccat tgctgctgaa 180 aacttgataa tcacacaagg cggtgctgtt tattcgcagt acttgtatgg gaacgccgga 240 acggatagca cacgaaacca gttgcgggca ccgctgcggc gaggactttt acccagcccc 300 gtgaccgtaa cgcttgacgt gaaaaaatat gcttcgtttg cagaaaaaat tatgaactac 360 tttgtctcgt ccagcgtcac atcgacaagt tttaaaatca aagacttaat aatgctctat 420 ctgtttcttt cacatacacc gaaatacaaa aaccttttct cctttattga aagtgttctt 480 ttccgcaaag acaaagagtg tgtaccggtt ttagagggtg aggcgacaag tgttatatta 540 gacaatctgc gagacttgac cggtatcaca aacattcgat tagattatga atctttaatg 600 gccgttaatg tttcactaca acgcaccacc agcgccgaac ttaacaagta tccacaggtt 660 aaagtgcgtg attatatcac aaacatgaat gtgtacgaaa aggttacgga cccctgtaaa 720 gcgtttgttg ataaatttca actactcctc tcgcagaagg ttcaacacat tgtggacgca 780 aaagataatt acttctcctt tggtaataac ccgctcatca ttgaaaatat agccattaat 840 attgaaaaga gttcggacat gaaccgcatg gttttcaacg ctattaacaa cattttcata 900 aacaccgttg agcagtgcgc ttcagagaac attaagtttg atgtggccga ctacaatcgg 960 cgatttcgaa ttatggatcg cgcacgtgaa agtggaaaga ataatttcgt tgaaaaggtt 1020 gcaattggag atgtggtgac cagaaaaaga tctaaaacca ccacgagcac tacttctgaa 1080 atcaaaagat ataaatctaa aaaatttgca gacgacgaat aact 1124 <210> 143 <211> 375 <212> PRT
<213> AsGV
<400> 143 Met Ser Ala Lys Thr Arg Leu Phe Leu Thr Ile Glu Lys Leu Lys Asn Ala Met Asp Asp Ala Gln Met Arg Phe Pro Phe Trp Glu Gln Phe Phe Pro Leu Leu Gly Asp Ala Thr Thr Ile Asp Val Asp Leu Ser Val Leu Ser Glu Leu Ile Asn Glu Ala Ala Ile Ala Ala Glu Asn Leu Ile Ile 1308 SEQ.LISTING.txt Thr Gln Gly Gly Ala Val Tyr Ser Gln Tyr Leu Tyr Gly Asn Ala Gly Thr Asp Ser Thr Arg Asn Gln Leu Arg Ala Pro Leu Arg Arg Gly Leu Leu Pro Ser Pro Val Thr Val Thr Leu Asp Val Lys Lys Tyr Ala Ser Phe Ala Glu Lys Ile Met Asn Tyr Phe Val Ser Ser Ser Val Thr Ser Thr Ser Phe Lys Ile Lys Asp Leu Ile Met Leu Tyr Leu Phe Leu Ser His Thr Pro Lys Tyr Lys Asn Leu Phe Ser Phe Ile Glu Ser Val Leu Phe Arg Lys Asp Lys Glu Cys Val Pro Val Leu Glu Gly Glu Ala Thr Ser Val Ile Leu Asp Asn Leu Arg Asp Leu Thr Gly Ile Thr Asn Ile Arg Leu Asp Tyr Glu Ser Leu Met Ala Val Asn Val Ser Leu Gln Arg Thr Thr Ser Ala Glu Leu Asn Lys Tyr Pro Gln Val Lys Val Arg Asp Tyr Ile Thr Asn Met Asn Val Tyr Glu Lys Val Thr Asp Pro Cys Lys Ala Phe Val Asp Lys Phe Gln Leu Leu Leu Ser Gln Lys Val Gln His Ile Val Asp Ala Lys Asp Asn Tyr Phe Ser Phe Gly Asn Asn Pro Leu Ile Ile Glu Asn Ile Ala Ile Asn Ile Glu Lys Ser Ser Asp Met Asn Arg Met Val Phe Asn Ala Ile Asn Asn Ile Phe Ile Asn Thr Val Glu Gln Cys Ala Ser Glu Asn Ile Lys Phe Asp Val Ala Asp Tyr Asn Arg Arg Phe Arg Ile Met Asp Arg Ala Arg Glu Ser Gly Lys Asn Asn Phe Val Glu Lys Val Ala Ile Gly Asp Val Val Thr Arg Lys Arg Ser Lys Thr Thr Thr Ser Thr Thr Ser Glu Ile Lys Arg Tyr Lys Ser Lys Lys Phe Ala Asp Asp Glu Cys Thr <210> 144 <211> 1391 <212> DNA
<213> AsGV
<400> 144 1308 SEQ.LISTING.txt atgtctctcg ttgtgctatc gctgttggta tcgggcgggt cgtgtgcaaa cattcttggg 60 gtttttccaa cgccgtcgta tagtcaccaa tcagtgtttg cggcttatgt cgataagctt 120 gccgccgccg ggcacaacgt gactgtgata acacctatga aacgtgcgac aggtcacgta 180 cgcgaaattg attgctcttt atcggtggaa cgtttccaag aattagtaag ccgttcaaaa 240 catattaaaa aacgaggagc ggttgctgat gagtttactg ttactaagga aaattatatg 300 ggtttaatta atgtggttgc gacgcagcta gaaactaacg ccgtgactgc gcttattaaa 360 aaccctttca acaaatttga tttggtggtt tgtgaagcgt atttggctta cacattaatt 420 tttggccata tttatgatgc acccgtgatc cagctttctt cgggtcatgg aattccggaa 480 aactttgaaa tacaaggcgc catagcgaga gattacgtta accatcctaa catatggcgt 540 tctaccttta ctggatcgcc gctggagcaa atgtttatgg aaaactatct gaagaacgaa 600 tggggattga ttgaaattga acaggaaaag atgttacgta aacgttttgg atatcacata 660 aaaatggaaa acctaaaaaa atcggtcctt atgctgttta taaatgtgcc cgctgtgtac 720 gataacttta ggcccgtcac cccaacagtg cagtatttgg gaggtttgca tctacgaaaa 780 gaacaaccga ttcgagattt ggtcctaaac cgttttttag aatcacactc tacgattgtg 840 tacgcgagtt ttggtagcgg gatagatgtg ctggacatgg atagaagctt actaaaggag 900 ttgatacgtg tttttagtaa gcttccttat ggaattctgt ggaaagtcga cgactctgtt 960 cacagcatat ataacgttag tgctaatgta tacacaaaat cttggtttcc tcaaagggat 1020 ttattgaagc atgagaacgt taaggcgttt ataacacagg cgggtgttca atcggccgat 1080 gaagcgatcg atggcggcgt acctatgatt acactaccca tgatgggaga tcagttttat 1140 aatgcgcacc gcttcgaaca attgggaatt ggaatacact tagatgtatt gaagctggaa 1200 aaggaaaggt tggataaaaa gattgttcag gtggttgaaa atagaaatta taaaaagaat 1260 attgaacgtt tgagacattt tattaacgat gtaccactga agtcgctacg caaatcgctt 1320 tggtatacaa attatgtcat acgaaaacaa aaaacattaa atgtaattaa aaatgtaaag 1380 tgtaattaac t 1391 <210> 145 <211> 464 <212> PRT
<213> AsGV
<400> 145 Met Ser Leu Val Val Leu Ser Leu Leu Val Ser Gly Gly Ser Cys Ala Asn Ile Leu Gly Val Phe Pro Thr Pro Ser Tyr Ser His Gln Ser Val Phe Ala Ala Tyr Val Asp Lys Leu Ala Ala Ala Gly His Asn Val Thr Val Ile Thr Pro Met Lys Arg Ala Thr Gly His Val Arg Glu Ile Asp Cys Ser Leu Ser Val Glu Arg Phe Gln Glu Leu Val Ser Arg Ser Lys His Ile Lys Lys Arg Gly Ala Val Ala Asp Glu Phe Thr Val Thr Lys Glu Asn Tyr Met Gly Leu Ile Asn Val Val Ala Thr Gln Leu Glu Thr Asn Ala Val Thr Ala Leu Ile Lys Asn Pro Phe Asn Lys Phe Asp Leu Val Val Cys Glu Ala Tyr Leu Ala Tyr Thr Leu Ile Phe Gly His Ile 1308 SEQ.LISTING.txt Tyr Asp Ala Pro Val Ile Gln Leu Ser Ser Gly His Gly Ile Pro Glu Asn Phe Glu Ile Gln Gly Ala Ile Ala Arg Asp Tyr Val Asn His Pro Asn Ile Trp Arg Ser Thr Phe Thr Gly Ser Pro Leu Glu Gln Met Phe Met Glu Asn Tyr Leu Lys Asn Glu Trp Gly Leu Ile Glu Ile Glu Gln Glu Lys Met Leu Arg Lys Arg Phe Gly Tyr His Ile Lys Met Glu Asn Leu Lys Lys Ser Val Leu Met Leu Phe Ile Asn Val Pro Ala Val Tyr Asp Asn Phe Arg Pro Val Thr Pro Thr Val Gln Tyr Leu Gly Gly Leu His Leu Arg Lys Glu Gln Pro Ile Arg Asp Leu Val Leu Asn Arg Phe Leu Glu Ser His Ser Thr Ile Val Tyr Ala Ser Phe Gly Ser Gly Ile Asp Val Leu Asp Met Asp Arg Ser Leu Leu Lys Glu Leu Ile Arg Val Phe Ser Lys Leu Pro Tyr Gly Ile Leu Trp Lys Val Asp Asp Ser Val His Ser Ile Tyr Asn Val Ser Ala Asn Val Tyr Thr Lys Ser Trp Phe Pro Gln Arg Asp Leu Leu Lys His Glu Asn Val Lys Ala Phe Ile Thr Gln Ala Gly Val Gln Ser Ala Asp Glu Ala Ile Asp Gly Gly Val Pro Met Ile Thr Leu Pro Met Met Gly Asp Gln Phe Tyr Asn Ala His Arg Phe Glu Gln Leu Gly Ile Gly Ile His Leu Asp Val Leu Lys Leu Glu Lys Glu Arg Leu Asp Lys Lys Ile Val Gln Val Val Glu Asn Arg Asn Tyr Lys Lys Asn Ile Glu Arg Leu Arg His Phe Ile Asn Asp Val Pro Leu Lys Ser Leu Arg Lys Ser Leu Trp Tyr Thr Asn Tyr Val Ile Arg Lys Gln Lys Thr Leu Asn Val Ile Lys Asn Val Lys Cys Asn Cys Thr <210> 146 <211> 1358 <212> DNA
<213> AsGV

1308 SEQ.LISTING.txt <400> 146 atggatccac tctttgtttc cgtatacgaa tttttgatac gacccaattc ttgcttttcg 60 cgaccaacgc cccagacgcc gcagcatttt ttgtacaagc tgtttaaaat atttcaagct 120 catcatcgca aagactacaa ggaggtgaag agtgttctta gcgatttact taatggcgtc 180 acaattgaag agaacaattt tttggcctcg caggaggccg ctgagcgttt tcaaatgcgc 240 ctaaaacggg aaagtgtcga ctttgaaaag atgtacgctc gcgaattgaa acgggccggc 300 agtgaagagg cacgaggacc tgtggcgaag aaggtgtgtg cgaggcgtaa aacatgcttt 360 gccatggtac aggaggctgc acaagaagcg ttgttaccac catttctttc tccgtttccc 420 ccatcacaga ggagcgccaa catcgacagt caagaagaag aagaaagtta cataataact 480 aaagaacaga acaacaacaa taacaacaac gatttgtttt acatgccgtc ttacgagcct 540 tcgggaggaa taatgcacac cttcacgatt ccatcgccgt gcaacgagaa catgctttct 600 ccatcttctt cggttataga aaatatctgt tcaccaccac cggtctacga gagtgaaatt 660 accaaaacgt cgctcgttta caccagcagc gatgacgagg aggaaggtga ttttatagaa 720 gagaaaacag tcaaagattt aaccaaaaaa aaagagatta ccactgaaca cgaggaggaa 780 gatatagaaa tgaaaacagt cgaaggatta accaaggaga aagagattac tactgaggcg 840 aagagaaaag ttgaaaataa aaaaacaact aaggtgacga cgaaaaaaca agtagcggca 900 tcgcgagtta tgatgaggcg tgctacagta gcggtgtgca acgaagttag tagtaccatg 960 accgatggtt catcagaatc atcttccgac gatgatgatg atgggaagat acataagaag 1020 gccaaggctc ctcgacgtgt gcgtaaaaag agtccaaagg gaattagctg ttatgtggac 1080 aacaatgata ttgtttgcat gattggaggg gtgagttata tgttgagagc tatgaaaact 1140 aaagaagtgt taatttatcc catggtagac ggtgacgaaa cagatttgag cagcctttgg 1200 gcaaatatga gcgatttact tatcgagaaa tacagaggtg ttgagaagaa acgcaataag 1260 cgtttaactt ttaatacgtt agattataag cgaaagtgta aggaattttt gttaaaccac 1320 ctgactgatt taaattttaa acggtttgat tcgtaact 1358 <210> 147 <211> 451 <212> PRT
<213> AsGV
<400> 147 Met Asp Pro Leu Phe Val Ser Val Tyr Glu Phe Leu Ile Arg Pro Asn Ser Cys Phe Ser Arg Pro Thr Pro Gln Thr Pro Gln His Phe Leu Tyr Lys Leu Phe Lys Ile Phe Gln Ala His His Arg Lys Asp Tyr Lys Glu Val Lys Ser Val Leu Ser Asp Leu Leu Asn Gly Val Thr Ile Glu Glu Asn Asn Phe Leu Ala Ser Gln Glu Ala Ala Glu Arg Phe Gln Met Arg Leu Lys Arg Glu Ser Val Asp Phe Glu Lys Met Tyr Ala Arg Glu Leu Lys Arg Ala Gly Ser Glu Glu Arg Pro Val Ala Lys Lys Val Cys Ala Arg Arg Lys Thr Cys Phe Ala Met Val Gln Glu Ala Ala Gln Glu Ala Leu Leu Pro Pro Phe Leu Ser Pro Phe Pro Pro Ser Gln Arg Ser Ala 1308 SEQ.LISTING.txt Asn Ile Asp Ser Gln Glu Glu Glu Glu Ser Tyr Ile Ile Thr Lys Glu Gln Asn Asn Asn Asn Asn Asn Asn Asp Leu Phe Tyr Met Pro Ser Tyr Glu Pro Ser Gly Gly Ile Met His Thr Phe Thr Ile Pro Ser Pro Cys Asn Glu Asn Met Leu Ser Pro Ser Ser Ser Val Ile Glu Asn Ile Cys Ser Pro Pro Pro Val Tyr Glu Ser Glu Ile Thr Lys Thr Ser Leu Val Tyr Thr Ser Ser Asp Asp Glu Glu Glu Gly Asp Phe Ile Glu Glu Lys Thr Val Lys Asp Leu Thr Lys Lys Lys Glu Ile Thr Thr Glu His Glu Glu Glu Asp Ile Glu Met Lys Thr Val Glu Gly Leu Thr Lys Glu Lys Glu Ile Thr Thr Glu Ala Lys Arg Lys Val Glu Asn Lys Lys Thr Thr Lys Val Thr Thr Lys Lys Gln Val Ala Ala Ser Arg Val Met Met Arg Arg Ala Thr Val Ala Val Cys Asn Glu Val Ser Ser Thr Met Thr Asp Gly Ser Ser Glu Ser Ser Ser Asp Asp Asp Asp Asp Gly Lys Ile His Lys Lys Ala Lys Ala Pro Arg Arg Val Arg Lys Lys Ser Pro Lys Gly Ile Ser Cys Tyr Val Asp Asn Asn Asp Ile Val Cys Met Ile Gly Gly Val Ser Tyr Met Leu Arg Ala Met Lys Thr Lys Glu Val Leu Ile Tyr Pro Met Val Asp Gly Asp Glu Thr Asp Leu Ser Ser Leu Trp Ala Asn Met Ser Asp Leu Leu Ile Glu Lys Tyr Arg Gly Val Glu Lys Lys Arg Asn Lys Arg Leu Thr Phe Asn Thr Leu Asp Tyr Lys Arg Lys Cys Lys Glu Phe Leu Leu Asn His Leu Thr Asp Leu Asn Phe Lys Arg Phe Asp Ser Cys Thr <210> 148 <211> 1187 <212> DNA
<213> AsGV

1308 SEQ.LISTING.txt <400> 148 atggcgcacg acattgaata cacacttaga ttttttaagg ttaccgatgc cggagtccaa 60 aatagtttgg tgacctttgt ctgctcttta aatgttagcg aaatagacac cgtcgccttt 120 ttgttggcag aatattttga ccaacagcat ctcttttcat tcgaacgtct tacatttttc 180 agtcagtata aacatgttat agaggtgatt aaaaaagatt atgaagcgcg aacggatacc 240 gatgaagaag tgaagcaaat ttttaaactc tttatagaaa acgattttat tggacaagtg 300 cccagctttc agttaattat gaaaagcatc ggaagctatc ttcacaaaat acctaatgta 360 gacgtgagca ctattgtatg cgacacttgt cccgctaata aacttgtctg tttaaaatgt 420 aaagccactt acgcttcgct aggattgagc gtaatggacg ctagtcttca ggagggctgg 480 gatgtgttct tccgtccgat gctcggtatt ccattactat tttttgcgct cttcaagagc 540 gacatgagcg gtgtggacaa agatgtgttc agcgtggata atattatcac taatattctt 600 ttacagtttt tttataatct gctatgcgat aaagccactc caatgtattg gaattttaaa 660 aagtgcaact tattaattga gcatacgcaa gactatgtca gaggtgtttc aaataaatct 720 ttggagtata tgctgcataa tttgaatagc acaacataca acactaaatt gtacaaccct 780 ttaaaacaat ttatggagca acactttagc acaaaacaaa tcggtaagct tatacataaa 840 atatttatcg gcttcttcct tagagtttat ttggaggcaa aacggcgtaa tatagagaga 900 ttaaatcaga agaggaaaag aaagtttaat gaagcagcgg acggtttgct ggttgacgtg 960 tacgacctgg aaactcgaaa tatttgcaga gtgcttttta aggattatga cgatgtggaa 1020 tttgaaacat ttatagaaaa gcttcaaggt ataaaaggcg agttggcaat cgaggtgtgc 1080 caaaaccttg tagtcccaaa ggagtgtgtt ttaagacttt ttaataagta caatctaaaa 1140 ggagacgtta gcaaactttt gcaaaagacc gtttcattgg cttagct 1187 <210> 149 <211> 396 <212> PRT
<213> AsGV
<400> 149 Met Ala His Asp Ile Glu Tyr Thr Leu Arg Phe Phe Lys Val Thr Asp Ala Gly Val Gln Asn Ser Leu Val Thr Phe Val Cys Ser Leu Asn Val Ser Glu Ile Asp Thr Val Ala Phe Leu Leu Ala Glu Tyr Phe Asp Gln Gln His Leu Phe Ser Phe Glu Arg Leu Thr Phe Phe Ser Gln Tyr Lys His Val Ile Glu Val Ile Lys Lys Asp Tyr Glu Ala Arg Thr Asp Thr Asp Glu Glu Val Lys Gln Ile Phe Lys Leu Phe Ile Glu Asn Asp Phe Ile Gly Gln Val Pro Ser Phe Gln Leu Ile Met Lys Ser Ile Gly Ser Tyr Leu His Lys Ile Pro Asn Val Asp Val Ser Thr Ile Val Cys Asp Thr Cys Pro Ala Asn Lys Leu Val Cys Leu Lys Cys Lys Ala Thr Tyr Ala Ser Leu Gly Leu Ser Val Met Asp Ala Ser Leu Gln Glu Gly Trp 1308 SEQ.LISTING.txt Asp Val Phe Phe Arg Pro Met Leu Gly Ile Pro Leu Leu Phe Phe Ala Leu Phe Lys Ser Asp Met Ser Gly Val Asp Lys Asp Val Phe Ser Val Asp Asn Ile Ile Thr Asn Ile Leu Leu Gln Phe Phe Tyr Asn Leu Leu Cys Asp Lys Ala Thr Pro Met Tyr Trp Asn Phe Lys Lys Cys Asn Leu Leu Ile Glu His Thr Gln Asp Tyr Val Arg Gly Val Ser Asn Lys Ser Leu Glu Tyr Met Leu His Asn Leu Asn Ser Thr Thr Tyr Asn Thr Lys Leu Tyr Asn Pro Leu Lys Gln Phe Met Glu Gln His Phe Ser Thr Lys Gln Ile Gly Lys Leu Ile His Lys Ile Phe Ile Gly Phe Phe Leu Arg Val Tyr Leu Glu Ala Lys Arg Arg Asn Ile Glu Arg Leu Asn Gln Lys Arg Lys Arg Lys Phe Asn Glu Ala Ala Asp Gly Leu Leu Val Asp Val Tyr Asp Leu Glu Thr Arg Asn Ile Cys Arg Val Leu Phe Lys Asp Tyr Asp Asp Val Glu Phe Glu Thr Phe Ile Glu Lys Leu Gln Gly Ile Lys Gly Glu Leu Ala Ile Glu Val Cys Gln Asn Leu Val Val Pro Lys Glu Cys Val Leu Arg Leu Phe Asn Lys Tyr Asn Leu Lys Gly Asp Val Ser Lys Leu Leu Gln Lys Thr Val Ser Leu Ala Cys Thr <210> 150 <211> 1118 <212> DNA
<213> AsGV
<400> 150 atgagtaaaa aagaaagacg cgcctcttta atgtacaatt tcaacattga aaatttgcgc 60 gaaaaaattc gaagccgcac cagcagtaag aataaggagg agcggtctgt tacaatggat 120 gaaaatagaa acactctaga tttagacatt tcaccacaac cgggacctag cagcgccaca 180 gtagaccccg ttccattggc cactttatct tacagggaca ccgaacacga ctacagttta 240 gcaccacctt ccggacccat agtggaaccg cctccgacta tacccgatga tttcggggaa 300 acacagcatt atcctatgac cgttgaagag gcaaaaaatt ttgatgccgt taacgcagta 360 ttaagagaga gggacgtctt tgaattggag tcttacgtga agcgagctct ggcgcccacc 420 atcaccgttg acggtcaacc catcgacccc tccaaggttt ttgtagcgaa agctcctcat 480 ttacccgaaa atagagattt ggcaatggtg cagctcatcg cgacatctta catcaacgaa 540 attatgggtt tgaacgaaac ggtgtatacg tttgtgcaaa gcagcgccgg agaccgcgct 600 1308 SEQ.LISTING.txt gtggggtacc tgtattttgc cagactttta tacgaaaacg gtctaaacac caatgtaccg 660 gcctttttaa agtgctgcga tgctatgaga gccatgtaca acagttgggc ggatcaagta 720 gaaagattgt ttccattgat tttaaattta aacggatttg atgttgttaa agaaacgatg 780 aatatagtaa atcagagcgt gtaccgtttg gtcacgtttg tgctggcatc tgaaggtgtt 840 agttccccaa aactttttta ccgtacggca ttacgaaacg cttccgacgt ctacgatggt 900 agagatgagc tagaaacgag gataatacga gaccagcagc tgttaactaa tttgtatgac 960 gagcggtttt ttaacgcttc taaagcgaaa aatgtgtata aattttacaa ggaagaaaag 1020 gaaacgccca ctttcaatct tggtcatatt aaactttata aactaaaggt ggctcctcat 1080 cagtttaaca aatttgaaat tatgcgaacg ttataact 1118 <210> 151 <211> 367 <212> PRT
<213> AsGV
<400> 151 Met Ser Lys Lys Glu Arg Arg Ala Ser Leu Met Tyr Asn Phe Asn Ile Glu Asn Leu Arg Glu Lys Ile Arg Ser Arg Thr Ser Ser Lys Asn Lys Glu Glu Arg Ser Val Thr Met Asp Glu Asn Arg Asn Thr Leu Asp Leu Asp Ile Ser Pro Gln Pro Gly Pro Ser Ser Ala Thr Val Asp Pro Val Pro Leu Ala Thr Leu Ser Tyr Arg Asp Thr Glu His Asp Tyr Ser Leu Ala Pro Pro Ser Gly Pro Ile Val Glu Pro Pro Pro Thr Ile Pro Asp Asp Phe Gly Glu Thr Gln His Tyr Pro Met Thr Val Glu Glu Ala Lys Asn Phe Asp Ala Val Asn Ala Val Leu Arg Glu Arg Asp Val Phe Glu Leu Glu Ser Tyr Val Lys Arg Ala Pro Thr Ile Thr Val Asp Gly Gln Pro Ile Asp Pro Ser Lys Val Phe Val Ala Lys Ala Pro His Leu Pro Glu Asn Arg Asp Leu Ala Met Val Gln Leu Ile Ala Thr Ser Tyr Ile Asn Glu Ile Met Gln Glu Thr Val Tyr Thr Phe Val Gln Ser Ser Ala Gly Asp Arg Ala Val Gly Tyr Leu Tyr Phe Ala Arg Leu Leu Tyr Glu Asn Gln Thr Asn Val Pro Ala Phe Leu Lys Cys Cys Asp Ala Met Arg Ala Met Tyr Asn Ser Trp Ala Asp Gln Val Glu Arg Leu Phe Pro Leu Ile Leu Asn Leu Asn Gly Phe Asp Val Val Lys Glu Thr Met Asn Ile 1308 SEQ.LISTING.txt Val Asn Gln Ser Val Tyr Arg Leu Val Thr Phe Val Leu Ala Ser Glu Gly Val Ser Ser Pro Lys Leu Phe Tyr Arg Thr Ala Leu Arg Asn Ala Ser Asp Val Tyr Asp Gly Arg Asp Glu Leu Glu Thr Arg Ile Ile Arg Asp Gln Gln Leu Leu Thr Asn Leu Tyr Asp Glu Arg Phe Phe Asn Ala Ser Lys Ala Lys Asn Val Tyr Lys Phe Tyr Lys Glu Glu Lys Glu Thr Pro Thr Phe Asn Leu Gly His Ile Lys Leu Tyr Lys Leu Lys Val Ala Pro His Gln Phe Asn Lys Phe Glu Ile Met Arg Thr Leu Cys Thr <210> 152 <211> 443 <212> DNA
<213> AsGV
<400> 152 atgcctcaat actcctgccc tttcactttg aactttgacg gtgtatgtgt accgcttatt 60 tttaacgaca tgattttgtg ggtgggtgcc gacgaagtgc ttaaaatttt acgtttaagt 120 cacaacttgt tacactgcct gccggaatgt gagaaaacaa ctttaagaca cctcgatcct 180 tgttgtgata gcaacaaatg ttatataaca gctctagggg ttggtttgct agtctgtaaa 240 catgttcata ggggcagtct tattaaagac gctataacta atgataactc tttaccagac 300 aagataaatg cttttgcaaa catattttta actgatgttg tgtgtgatat taagaccgac 360 agactgttgt gtagtattag taagaaagaa aacgatattc ttgctatact aaatgaaccc 420 ttatctttgc ccgtcgtgtg act 443 <210> 153 <211> 148 <212> PRT
<213> AsGV
<400> 153 Met Pro Gln Tyr Ser Cys Pro Phe Thr Leu Asn Phe Asp G1y Val Cys Val Pro Leu Ile Phe Asn Asp Met Ile Leu Trp Val Gly Ala Asp Glu Val Leu Lys Ile Leu Arg Leu Ser His Asn Leu Leu His Cys Leu Pro Glu Cys Glu Lys Thr Thr Leu Arg His Leu Asp Pro Cys Cys Asp Ser Asn Lys Cys Tyr Ile Thr Ala Leu Gly Val Gly Leu Leu Val Cys Lys His Val His Arg Gly Ser Leu Ile Lys Asp Ala Ile Thr Asn Asp Asn 1308 SEQ.LISTING.txt Ser Leu Pro Asp Lys Ile Asn Ala Phe Ala Asn Ile Phe Leu Thr Asp Val Val Cys Asp Ile Lys Thr Asp Arg Leu Leu Cys Ser Ile Ser Lys Lys Glu Asn Asp Ile Leu Ala Ile Leu Asn Glu Pro Leu Ser Leu Pro Val Val Cys Thr <210> 154 <211> 1646 <212> DNA
<213> AsGV
<400> 154 atgcagctcg ggttgggact atctatatta tttgtcatag tgatatgttt gatagcttat 60 catggtgcca acatgacaat gtttcgacga ataaacaaca agagaaagta tttagaattc 120 tacgacaact cttcggttcc gcgtatagaa cctcccgaag agatttatat tcctccaaat 180 cctctcgagt gtcacacgcc cccgttaaca aaatgtacaa gcaatgccga ttgtcaatta 240 tgtcaggaaa ccagagcgct ctgtcaagag tttaacgaac agatcacttt ggaatttggg 300 gaagatgagt ctattattat agaaccggga gagaaatatt gcattgcttt gaatgacgag 360 cgcgcacgta actgtaaccc caacactgga ttatggataa tgcgacgtta cagtgaagat 420 acatttagtc ttatttgtca ttgcacatat cctggtttgg taacccaatt aactttgtat 480 gatgactgcg attacccggt tggatgccgt ccccatggct acatagccga cattaacgca 540 tcaccattaa gatgtgagtg tgacaacggg tatgtttcag acatttctat atcgatgaca 600 ccctattgta gacagcaaac aataagagac aaaatattag accccgagtt tttccctcgt 660 cctccttgcc caaatggtat gatttcaaca gatttttggg ccttcaataa cacctaccta 720 caacaaacta acggcgttcc aatatgtata atggaccctt gttcgtttga ccccatctcg 780 ggcgaaagga cttctggtta catgtacgag ttttatgatt atatggagaa aacacagata 840 gcgtattgtg tctgcgacta tgaagattcc ctttatcccg tttacagtcc tacaacaatg 900 tttaccggac atccatttac agtagatttt ccaaacgcat gtataaaacc gctgcggttt 960 gatagaaaat ttttccatgc cgacgtcaag tcgttttggg gccgagcgga aaccacttgc 1020 gatatggatg ttgttataca aaccgaactt gatttaatta gtccgaatta ccaaaaaatt 1080 tgttttcttc gacaaaaaaa gcatccacat ccgtacggag gtacagactt taaccctata 1140 gacgaacgta actttataat aaaatttaca attagcgctt ttagacaagt tactcatcgg 1200 ataccacagg tcgatgtata tcaactgtat actacaacag aaaatcgtta ctttgaggat 1260 tacgagcgct gtttcagaga aggtgttggt gaatgtatgt gggaaatgaa agaagagtgt 1320 gttgttcgtt tcaactgggt cgaggctgga atggcgtgct tcttcacgac aagaagagaa 1380 tttttgttac caatgcgttt agaagctttt aaaattatgt gctacgggcg gccaacatta 1440 tacagagatg gagaaattca agttgtccac tatgtaaatg ctaattttga cacatttgcg 1500 gattcgacga cagaacattt tacgcagaga gagaacctta gaatgtacgt gatgattgca 1560 actggtcaaa cggtccatca ttataatgat tatgcgaacg ctggtgtagt attaggcaca 1620 tatcctcatt attctgcatt ataact 1646 <210> 155 <211> 545 <212> PRT
<213> AsGV
1308 SEQ.LISTING.txt <400> 155 Met Gln Leu Gly Leu Gly Leu Ser Ile Leu Phe Val Ile Val Ile Cys Leu Ile Ala Tyr His Gly Ala Asn Met Thr Met Phe Arg Arg Ile Asn Asn Lys Arg Lys Tyr Leu Glu Phe Tyr Asp Asn Ser Ser Val Pro Arg Ile Glu Pro Pro Glu Glu Ile Tyr Ile Pro Pro Asn Pro Leu Glu Cys His Thr Pro Pro Leu Thr Lys Cys Thr Ser Asn Ala Asp Cys Gln Leu Cys Gln Glu Thr Arg Ala Leu Cys Gln Glu Phe Asn Glu Gln Ile Thr Leu Glu Phe Gly Glu Asp Glu Ser Ile Ile Ile Glu Pro Gly Glu Lys Tyr Cys Ile Ala Leu Asn Asp Glu Arg Ala Arg Asn Cys Asn Pro Asn Thr Gly Leu Trp Ile Met Arg Arg Tyr Ser Glu Asp Thr Phe Ser Leu Ile Cys His Cys Thr Tyr Pro Gly Leu Val Thr Gln Leu Thr Leu Tyr '145 150 155 160 Asp Asp Cys Asp Tyr Pro Val Gly Cys Arg Pro His Gly Tyr Ile Ala Asp Ile Asn Asp Leu Arg Cys Glu Cys Asp Asn Gly Tyr Val Ser Asp Ile Ser Ile Ser Met Thr Pro Tyr Cys Arg Gln Gln Thr Ile Arg Asp Lys Ile Leu Asp Pro Glu Phe Phe Pro Arg Pro Pro Cys Pro Asn Gly Met Ile Ser Thr Asp Phe Trp Ala Phe Asn Asn Thr Tyr Leu Gln Gln Thr Asn Gly Val Pro Ile Cys Ile Met Asp Pro Cys Ser Phe Asp Pro Ile Ser Gly Glu Arg Thr Ser Gly Tyr Met Tyr Glu Phe Tyr Asp Tyr Met Glu Lys Thr Gln Ile Ala Tyr Cys Val Cys Asp Tyr Glu Asp Ser Leu Tyr Pro Val Tyr Ser Pro Thr Thr Met Phe Thr Gly His Pro Phe Thr Val Asp Phe Pro Asn Ala Cys Ile Lys Pro Leu Arg Phe Asp Arg Lys Phe Phe His Ala Asp Val Lys Ser Phe Trp Gly Arg Ala Glu Thr Thr Cys Asp Met Asp Va1 Val Ile Gln Thr Glu Leu Asp Leu Ile Ser 1308 SEQ.LISTING.txt Pro Asn Tyr Gln Lys Ile Cys Phe Leu Arg Gln Lys Lys His Pro His Pro Tyr Gly Gly Thr Asp Phe Asn Pro Ile Asp Glu Arg Asn Phe Ile Ile Lys Phe Thr Ile Ser Ala Phe Arg Gln Val Thr Ile Pro Gln Val Asp Val Tyr Gln Leu Tyr Thr Thr Thr Glu Asn Arg Tyr Phe Glu Asp Tyr Glu Arg Cys Phe Arg Glu Gly Val Gly Glu Cys Met Trp Glu Met Lys Glu Glu Cys Val Val Arg Phe Asn Trp Val Glu Ala Gly Met Ala Cys Phe Phe Thr Thr Arg Arg Glu Phe Leu Leu Pro Met Arg Leu Glu Ala Phe Lys Ile Met Cys Tyr Gly Arg Pro Thr Leu Tyr Arg Asp Gly Glu Ile Gln Val Val His Tyr Val Asn Ala Asn Phe Asp Thr Phe Ala Asp Ser Thr Thr Glu His Phe Thr Gln Arg Glu Asn Leu Arg Met Tyr Val Met Ile Ala Thr Gly Gln Thr Val His His Tyr Asn Asp Tyr Ala Asn Ala Gly Val Val Leu Gly Thr Tyr Pro His Tyr Ser Ala Leu Cys Thr <210> 156 <211> 1436 <212> DNA
<213> AsGV
<400> 156 atgacactct ctctactatg tgtactattt attatttccg cttcaaccac cgacatcaca 60 tttaaatcca cactcgaagc gtacactatc gacggacgag gtttgtgtat tggcgattgt 120 gttttaacca aaagcgaaga gagatgtata tttaaatata atatggccac aacacagtgt 180 tcttcgtcca ataaacccac caaacgttac cgtacattat ataatagacc ctgttatagt 240 aactgcgatt atttcgaaaa cgaatactac agttggtgcg tcgagaagag agacaacaac 300 tttagatggg attattgtac cagaaatatt gcgcttaaag gtaaagaagt tattaggaca 360 gataataagt atatgacatg cggttatact acatgtggaa aacataatta ttttacgtac 420 aattggtgcg gtaccatagg aacatattgg gaatattgta atccggccaa taaagtaatt 480 ctgtttgaat acacgactga tgtaaacacc aaatgtgcat ccccttgtga gatggatcgc 540 aacaacgtag gttattgtta cgacatcaac tacagatggt ctaattgtta cttgaatcca 600 gacttttcaa atacactaga agacgttcat acggcatggt tggcgcaata taatacgggc 660 ggtatataca ctttagacaa agaatatttg ttatgtgata gaccacaaga tgttaagggt 720 gttgaagata gaaataaaga agaagctcat aataaaattt ttaatcactt tccgccccgt 780 cttggtttaa gtatccacag atcgtattcg actgtgcaag atgtagtgga tctttataga 840 1308 SEQ.LISTING.txt aaaaataatc cgacggtata tttgcgccac cctgatgtgg acccctcggc gaacaataat 900 agcaatccgg tcctctacta cacagtcagt ccagttccaa atcgaattgg cgaagatcaa 960 tttaatctcc ctttagttgt gcacgcgata ataacaaatt acactctaac aaataaaatg 1020 gtgttgttca gtacagccac gccttcaata caccgctaca tgaacaagat ggatattacg 1080 gatttcgacg aaccttccta tataattggc actcgtctcg gcggctcttc gaagctatac 1140 aatatgtttc ctagaccttc taattatctt acacatgaag aaaaccagtg gcacgattta 1200 gaagagaaaa ttataaattt tttgaagagc aaaaacaagc gttatgtgga gtattgggcc 1260 gttctaactt atactaagtc ttcgtttcgc ccctcttttg tcggtgtttg tgtaagactt 1320 tatgaagata acgattttgt aaactttgac ggtaaatcca ttacaattgc caccaatcct 1380 ttagaaaata tgcatttcac taatgagcgc acccctcaca aatgtagatt atagct 1436 <210> 157 <211> 475 <212> PRT
<213> AsGV
<400> 157 Met Thr Leu Ser Leu Leu Cys Val Leu Phe Ile Ile Ser Ala Ser Thr Thr Asp Ile Thr Phe Lys Ser Thr Leu Glu Ala Tyr Thr Ile Asp Gly Arg Gly Leu Cys Ile Gly Asp Cys Val Leu Thr Lys Ser Glu Glu Arg Cys Ile Phe Lys Tyr Asn Met Ala Thr Thr Gln Cys Ser Ser Ser Asn Lys Pro Thr Lys Arg Tyr Arg Thr Leu Tyr Asn Arg Pro Cys Asn Cys Asp Tyr Phe Glu Asn Glu Tyr Tyr Ser Trp Cys Val Glu Lys Arg Asp Asn Asn Phe Arg Trp Asp Tyr Cys Thr Arg Asn Ile Ala Leu Lys Gly Lys Glu Val Ile Arg Thr Asp Asn Lys Tyr Met Thr Cys Gly Tyr Thr Thr Cys Gly Lys His Asn Tyr Phe Thr Tyr Asn Trp Cys Gly Thr Ile Gly Thr Tyr Trp Glu Tyr Cys Asn Pro Ala Asn Lys Val Ile Leu Phe Glu Tyr Thr Thr Asp Val Asn Thr Lys Cys Asp Cys Glu Met Asp Arg Asn Asn Val Gly Tyr Cys Tyr Asp Ile Asn Tyr Arg Trp Ser Asn Cys Tyr Leu Asn Pro Asp Phe Ser Asn Thr Leu Glu Asp Val His Thr Ala Trp Leu Ala Gln Tyr Asn Thr Gly Gly Ile Tyr Thr Leu Asp Lys Glu Tyr Leu Leu Cys Asp Arg Pro Gln Asp Val Lys Gly Val Glu Asp Arg Asn Lys Glu Glu Ala His Asn Lys Ile Phe Asn His Phe Pro Pro Arg SEQ.LISTING.txt LeuGly Leu Ser Ile His Arg Ser Tyr Ser Thr Val GlnAsp Val Val AspLeu Tyr Arg Lys Asn Asn Pro Thr Val Tyr Leu ArgHis Pro Asp ValAsp Pro Ser Ala Asn Asn Asn Ser Asn Pro Val LeuTyr Tyr Thr ValSer Pro Val Pro Asn Arg Ile Gly Glu Asp Gln PheAsn Leu Pro LeuVal Val His Ala Ile Ile Thr Asn Tyr Thr Leu ThrAsn Lys Met ValLeu Phe Ser Thr Ala Thr Pro Ser Ile His Arg TyrMet Asn Lys MetAsp Ile Thr Asp Phe Asp Glu Pro Ser Tyr Ile IleGly Thr Arg LeuGly Gly Ser Ser Lys Leu Tyr Asn Met Phe Pro ArgPro Ser Asn TyrLeu Thr His Glu Glu Asn Gln Trp His Asp Leu GluGlu Lys Ile IleAsn Phe Leu Lys Ser Lys Asn Lys Arg Tyr Val GluTyr Trp Ala ValLeu Thr Tyr Thr Lys Ser Ser Phe Arg Pro Ser PheVal Gly Val CysVal Arg Leu Tyr Glu Asp Asn Asp Phe Val Asn PheAsp Gly Lys SerIle Thr Ile Ala Thr Asn Pro Leu Glu Asn Met HisPhe Thr Asn GluArg Thr Pro His Lys Cys Arg Leu Cys Thr <210> 158 <211> 1055 <212> DNA
<213> AsGV
<400> 158 atggccaggc taatattttc gactcgtgta gatggcaccg acgtgccagt gttttacggg 60 ggcgcgcctg gggataaacc atatgtgggc gtcgctgaat tgctaaatat tttaggtcat 120 agcaagacgc acgcggacga atttccgcgt agcgaaacaa aattatggca ggatttagcg 180 cccaatgaca gcacttaccc accaaataaa ctattcacaa cagaagtggg ttttgcagtg 240 tattttggaa aaactaaact aacaaactgg gccgctttta aacgtatgtt tgacaccatc 300 gctcaataca ttgccgaccc tagcgcctgc aacgcttcaa acccacaatg tatgataccg 360 cccggccaca gctccggttg cggtccatgt ccccagcctc caaacggcgg cgggggtggt 420 ggtaaatgtg aatatcttaa tgcgatcctt ttaggagtac aaaacaacaa cgctctcctt 480 caggccattc tagcagatat tcaaaaactg attaataatg gagggggagg tggtggtaac 540 gtggacctca caccaatttt acaagcaatt gctgccctca caactttggt taacggaata 600 caatcatctg tagttgatct agacacctct ataaatgctc gtttcgacac cctcgagacc 660 1308 SEQ.LISTING.txt cgtctcgaca ctctggaaca gaatcttaac aatcgtctgg acacctttga tactcgatta 720 accgctttgg aaggtcaaat tactgattta caaagcgatg tggctaatat actaaatgtt 780 ttaccaaatc ttgtgaccac cctcaatgct tttacgcaag gggttgttac gcaatgggga 840 gaagcggcat gggacgatga ggcgtacccc gttccttcaa ttcctcccat aacacccaac 900 gtcctaaacg acggtaaaaa aaatgttctt tcagaagatg tcgctcaaag tcttaatagt 960 ttgcaaaaag aggttaaacg tctcaacgat tacacagatg actttcagca aatcttaaaa 1020 aaggttgata taaaaagcaa ggagagaata taact 1055 <210> 159 <211> 350 <212> PRT
<213> AsGV
<400> 159 Met Ala Arg Leu Ile Phe Ser Thr Arg Val Asp Gly Thr Asp Val Pro Val Phe Tyr Gly Gly Ala Pro Gly Asp Lys Pro Tyr Val Gly Val Ala Glu Leu Leu Asn Ile Leu Gly His Ser Lys Thr His Ala Asp Glu Phe Pro Arg Ser Glu Thr Lys Leu Trp Gln Asp Leu Ala Pro Asn Asp Ser Thr Tyr Pro Pro Asn Lys Leu Phe Thr Thr Glu Val Gly Phe Ala Val Tyr Phe Gly Lys Thr Lys Leu Thr Asn Trp Ala Ala Phe Lys Arg Met Phe Asp Thr Ile Ala Gln Tyr Ile Ala Asp Pro Ser Ala Cys Asn Asn Pro Gln Cys Met Ile Pro Pro Gly His Ser Ser Gly Cys Gly Pro Cys Pro Gln Pro Pro Asn Gly Gly Gly Gly Gly Gly Lys Cys Glu Tyr Leu Asn Ala Ile Leu Leu Gly Val Gln Asn Asn Asn Ala Leu Leu Gln Ala Ile Leu Ala Asp Ile Gln Lys Leu Ile Asn Asn Gly Gly Gly Gly Gly Gly Asn Val Asp Leu Thr Pro Ile Leu Gln Ala Ile Ala Ala Leu Thr Thr Leu Val Asn Gly Ile Gln Ser Ser Val Val Asp Leu Asp Thr Ser Ile Asn Ala Arg Phe Asp Thr Leu Glu Thr Arg Leu Asp Thr Leu Glu Gln Asn Leu Asn Asn Arg Leu Asp Thr Phe Asp Thr Arg Leu Thr Ala Leu Glu Gly Gln Ile Thr Asp Leu Gln Ser Asp Val Ala Asn Ile Leu Asn Val Leu Pro Asn Leu Val Thr Thr Leu Asn Ala Phe Thr Gln Gly 1308 SEQ.LISTING.txt Val Val Thr Gln Trp Gly Glu Ala Ala Trp Asp Asp Glu Ala Tyr Pro Val Pro Ser Ile Pro Pro Ile Thr Pro Asn Val Leu Asn Asp Gly Lys Lys Asn Val Leu Ser Glu Asp Val Ala Gln Ser Leu Asn Ser Leu Gln Lys Glu Val Lys Arg Leu Asn Asp Tyr Thr Asp Asp Phe Gln Gln Ile Leu Lys Lys Val Asp Ile Lys Ser Lys Glu Arg Ile Cys Thr <210> 160 <211> 536 <212> DNA
<213> AsGV
<400> 160 atggcgttcg aatacaattc cggtcccatc gaagtgttta ttgttactaa cgacgaaggt 60 ttggtgaatg gctacgcaga agtaaacgcg gtgacccaat tgctgtcacc ttatacccgc 120 ctctctcata ctcaactttg gaacgcaacc catcccgcgt acaggattca gaacaacaac 180 aaaaatttta ttcatgccat tgtaataagt aaatatctcg ccgctattcc ggaaacggag 240 gcgcagagtt acaaaaacct gcggcaattg gtgcgcgatt tacttgtggg agaccagaat 300 gaagaaaaca atgagcaaat tgagggtata aagaagaatt tggaggaaat caaagacaag 360 ttggaggaga aaaataatta tttgagcgat tttagcggct tgctaaatgt tttaaagagt 420 gaaatcgtga gcgaaattcg tgatctactt aaattgtcaa acgaaccagt gaagacgaag 480 gaaaaagaag atgatgcgtt ggtagagttg tgtgtaatta aagaagaaaa ataact 536 <210> 161 <211> 179 <212> PRT
<213> AsGV
<400> 161 Met Ala Phe Glu Tyr Asn Ser Gly Pro Ile Glu Val Phe Ile Val Thr Asn Asp Glu Gly Leu Val Asn Gly Tyr Ala Glu Val Asn Ala Val Thr Gln Leu Leu Ser Pro Tyr Thr Arg Leu Ser His Thr Gln Leu Trp Asn Ala Thr His Pro Ala Tyr Arg Ile Gln Asn Asn Asn Lys Asn Phe Ile His Ala Ile Val Ile Ser Lys Tyr Leu Ala Ala Ile Pro Glu Thr Glu Ala Gln Ser Tyr Lys Asn Leu Arg Gln Leu Val Arg Asp Leu Leu Val Gly Asp Gln Asn Glu Glu Asn Asn Glu Gln Ile Glu Gly Ile Lys Lys DEMANDES OU BREVETS VOLUMINEUX
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Claims (39)

Claims That which is claimed is:

1. An isolated peptide comprising an amino acid sequence selected from the group consisting of:
(a) an amino acid sequence shown in SEQ ID NOS: 3, 5, 7...215, 217;
(b) a variant of an amino acid sequence shown in SEQ ID NOS: 3, 5, 7...215, 217, wherein said variant is encoded by a nucleic acid molecule that hybridizes under stringent conditions to the opposite strand of a nucleic acid molecule shown in SEQ ID
NOS: 2, 4, 6...214, 216;
(c) an amino acid sequence of an ortholog of an amino acid sequence shown in SEQ
ID NOS: 3, 5, 7...215, 217, wherein said ortholog is encoded by a nucleic acid molecule that hybridizes under stringent conditions to the opposite strand of a nucleic acid molecule shown in SEQ ID NOS: 2, 4, 6...214, 216; and (d) a fragment of an amino acid sequence shown in SEQ ID NOS: 3, 5, 7...215, 217, wherein said fragment comprises at least 10 contiguous amino acids.

2. An isolated peptide consisting of an amino acid sequence selected from the group consisting of:
(a) an amino acid sequence shown in SEQ ID NOS: 3, 5, 7...215, 217.
(b) a variant of an amino acid sequence shown in SEQ ID NOS: 3, 5, 7...215, 217, wherein said variant is encoded by a nucleic acid molecule that hybridizes under stringent conditions to the opposite strand of a nucleic acid molecule shown in SEQ ID
NOS: 2, 4, 6...214, 216;
(c) an amino acid sequence of an ortholog of an amino acid sequence shown in SEQ
ID NOS: 3, 5, 7...215, 217, wherein said ortholog is encoded by a nucleic acid molecule that hybridizes under stringent conditions to the opposite strand of a nucleic acid molecule shown in SEQ ID NOS: 2, 4, 6...214, 216; and (d) a fragment of an amino acid sequence shown in SEQ ID NOS: 3, 5, 7...215, 217, wherein said fragment comprises at least 10 contiguous amino acids.

3. An isolated antibody that selectively binds to a peptide of claim 1.

4. An isolated nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of:
(a) a nucleotide sequence that encodes an amino acid sequence shown in SEQ ID
NOS: 3, 5, 7...215, 217;
(b) a nucleotide sequence that encodes a variant of an amino acid sequence shown in SEQ ID NOS: 3, 5, 7...215, 217, wherein said nucleotide sequence hybridizes under stringent conditions to the opposite strand of a nucleic acid molecule shown in SEQ ID
NOS: 2, 4, 6...214, 216;
(c) a nucleotide sequence that encodes an ortholog of an amino acid sequence shown in SEQ ID NOS: 3, 5, 7...215, 217, wherein said nucleotide sequence hybridizes under stringent conditions to the opposite strand of a nucleic acid molecule shown in SEQ ID
NOS: 2, 4, 6...214, 216;
(d) a nucleotide sequence that encodes a fragment of an amino acid sequence shown in SEQ ID NOS: 3, 5, 7...215, 217, wherein said fragment comprises at least 10 contiguous amino acids; and (e) a nucleotide sequence that is the complement of a nucleotide sequence of (a)-(d).

5. An isolated nucleic acid molecule consisting of a nucleotide sequence selected from the group consisting of:
(a) a nucleotide sequence that encodes an amino acid sequence shown in SEQ ID
NOS: 3, 5, 7...215, 217;
(b) a variant of an amino acid sequence shown in SEQ ID NOS: 3, 5, 7...215, 217, wherein said nucleotide sequence hybridizes under stringent conditions to the opposite strand of a nucleic acid molecule shown in SEQ ID NOS: 2, 4, 6...214, 216;
(c) a nucleotide sequence that encodes an ortholog of an amino acid sequence shown in SEQ ID NOS: 3, 5, 7...215, 217, wherein said nucleotide sequence hybridizes under stringent conditions to the opposite strand of a nucleic acid molecule shown in SEQ ID
NOS: 2, 4, 6...214, 216;
(d) a nucleotide sequence that encodes a fragment of an amino acid sequence shown in SEQ ID NOS: 3, 5, 7...215, 217, wherein said fragment comprises at least 10 contiguous amino acids; and (e) a nucleotide sequence that is the complement of a nucleotide sequence of (a)-(d).

6. A gene chip comprising a nucleic acid molecule of claims 4 or 5.

7. A transgenic non-human organism comprising a nucleic acid molecule of claims 4 or 5.

8. A nucleic acid vector comprising a nucleic acid molecule of claims 4 or 5.

9. A host cell containing the vector of claim 8.

10. A method for producing any of the peptides of claim 1 comprising introducing a nucleotide sequence encoding any of the amino acid sequences in (a)-(d) into a host cell, and culturing the host cell under conditions in which the peptides are expressed from the nucleotide sequence.

11. A method for producing any of the peptides of claim 2 comprising introducing a nucleotide sequence encoding any of the amino acid sequences in (a)-(d) into a host cell, and culturing the host cell under conditions in which the peptides are expressed from the nucleotide sequence.

12. A method for detecting the presence of any of the peptides of claims 1 or 2 in a sample, said method comprising contacting said sample with a detection agent that specifically allows detection of the presence of the peptide in the sample and then detecting the presence of the peptide.

13. A method for detecting the presence of a nucleic acid molecule of claims 4 or 5 in a sample, said method comprising contacting the sample with an oligonucleotide that hybridizes to said nucleic acid molecule under stringent conditions and determining whether the oligonucleotide binds to said nucleic acid molecule in the sample.

14. A method for identifying a modulator of a peptide of claims 1 or 2, said method comprising contacting said peptide with an agent and determining if said agent has modulated the function or activity of said peptide.

15. The method of claim 14, wherein said agent is administered to a host cell comprising an expression vector that expresses said peptide.

16. A method for identifying an agent that binds to any of the peptides of claims 1 or 2, said method comprising contacting the peptide with an agent and assaying the contacted mixture to determine whether a complex is formed with the agent bound to the peptide.

17. A pharmaceutical composition comprising an agent identified by the method of claim 16 and a pharmaceutically acceptable carrier therefor.

18. A method for treating AsGV infection, said method comprising administering to an organism a pharmaceutically effective amount of an agent identified by the method of claim 16.

19. A method for identifying a modulator of the expression of a peptide of claims 1 or 2, said method comprising contacting a cell expressing said peptide with an agent, and determining if said agent has modulated the expression of said peptide.

20. An isolated AsGV peptide having an amino acid sequence that shares at least 70%
homology with an amino acid sequence shown in SEQ ID NOS: 3, 5, 7...215, 217.

21. A peptide according to claim 20 that shares at least 90 percent homology with an amino acid sequence shown in SEQ ID NOS: 3, 5, 7...215, 217.

22. An isolated nucleic acid molecule encoding a AsGV peptide, said nucleic acid molecule sharing at least 80 percent homology with a nucleic acid molecule shown in SEQ ID
NOS: 2, 4, 6...214, 216.

23. A nucleic acid molecule according to claim 22 that shares at least 90 percent homology with a nucleic acid molecule shown in SEQ ID NOS: 2, 4, 6.,.214, 216.

24. An isolated nucleic acid detection reagent that is capable of detecting the presence of 1 or more genes from AsGV, wherein said genes are selected from the group consisting of SEQ
ID NOS: 2, 4, 6...214, 216.

25. The detection reagent of claim 24, wherein said reagent is a nucleic acid array.

26. The array of claim 25, wherein said array is comprised of short oligonucleotides from about 5 to about 100 nucleotides in length.

27. The array of claim 25, wherein said array is comprised of polynucleotides based on the transcript sequences (SEQ ID NOS: 2, 4, 6...214, 216), wherein said polynucleotides are from about 100 to about 1000 nucleotides in length.

28. An isolated nucleic acid detection reagent that is capable of detecting the presence of or more genes from AsGV, wherein said genes are selected from the group consisting of SEQ ID NOS: 2, 4, 6...214, 216.

29. The detection reagent of claim 28, wherein said reagent is a nucleic acid array.

30. The array of claim 29, wherein said array is comprised of short oligonucleotides from about 5 to about 100 nucleotides in length.

31. The array of claim 29, wherein said array is comprised of polynucleotides based on the transcript sequences (SEQ ID NOS: 2, 4, 6...214, 216), wherein said polynucleotides are from about 100 to about 1000 nucleotides in length.

32. An isolated nucleic acid detection reagent that is capable of detecting the presence of 100 or more genes from AsGV, wherein said genes are selected from the group consisting of SEQ ID NOS: 2, 4, 6...214, 216.

33. The detection reagent of claim 32, wherein said reagent is a nucleic acid array.

34. The array of claim 33, wherein said array is comprised of short oligonucleotides from about 5 to about 100 nucleotides in length.

35. The array of claim 33, wherein said array is comprised of polynucleotides based on the transcript sequences (SEQ ID NOS: 2, 4, 6...214, 216), wherein said polynucleotides are from about 100 to about 1000 nucleotides in length.

36. An isolated nucleic acid detection reagent that is capable of detecting the presence of all genes from AsGV, wherein said genes are selected from the group consisting of SEQ ID
NOS: 2, 4, 6...214, 216.

37. The detection reagent of claim 36, wherein said reagent is a nucleic acid array.

38. The array of claim 37, wherein said array is comprised of short oligonucleotides from about 5 to about 100 nucleotides in length.

39. The array of claim 38, wherein said array is comprised of polynucleotides based on the transcript sequences (SEQ ID NOS: 2, 4, 6...214, 216), wherein said polynucleotides are from about 100 to about 1000 nucleotides in length.