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CA2443277A1 - Variantes polypeptidiques a interferon gamma - Google Patents

Variantes polypeptidiques a interferon gamma Download PDF

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Publication number
CA2443277A1
CA2443277A1 CA002443277A CA2443277A CA2443277A1 CA 2443277 A1 CA2443277 A1 CA 2443277A1 CA 002443277 A CA002443277 A CA 002443277A CA 2443277 A CA2443277 A CA 2443277A CA 2443277 A1 CA2443277 A1 CA 2443277A1
Authority
CA
Canada
Prior art keywords
seq
variant
lys
polypeptide
ifng
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002443277A
Other languages
English (en)
Inventor
Anne Dam Jensen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Maxygen Holdings Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2443277A1 publication Critical patent/CA2443277A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/57—IFN-gamma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention concerne de nouvelles variantes polypeptidiques à interféron gamma ayant une activité d'interferon gamma (IFNG), leurs procédés de préparation, les compositions pharmaceutiques contenant ces variantes polypeptidiques et leur utilisation pour traiter des maladies, notamment des maladies pulmonaires interstitielles comme la fibrose pulmonaire idiopathique. Toutes ces nouvelles variantes polypeptidiques contiennent la substitution S99T comparé à la séquence d'acides aminés de huIFNG ou à des fragments de cette dernière. Cette mutation permet de nettement mieux utiliser le site de N-glycosylation apparaissant naturellement et étant présent à la position 97. Ces variantes contiennent naturellement d'autres modifications, notamment de l'ordre de l'augmentation de la surface sous la courbe de telles variantes en cas d'administration sous-cutanée.
CA002443277A 2001-04-06 2002-04-04 Variantes polypeptidiques a interferon gamma Abandoned CA2443277A1 (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
DKPA200100579 2001-04-06
DKPA200100579 2001-04-06
DKPA200100714 2001-05-07
DKPA200100714 2001-05-07
DKPA200200198 2002-02-11
DKPA200200198 2002-02-11
PCT/DK2002/000226 WO2002081507A2 (fr) 2001-04-06 2002-04-04 Variantes polypeptidiques a interferon gamma

Publications (1)

Publication Number Publication Date
CA2443277A1 true CA2443277A1 (fr) 2002-10-17

Family

ID=27222504

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002443277A Abandoned CA2443277A1 (fr) 2001-04-06 2002-04-04 Variantes polypeptidiques a interferon gamma

Country Status (15)

Country Link
EP (1) EP1412382A2 (fr)
JP (1) JP2005518183A (fr)
KR (1) KR20030094336A (fr)
CN (1) CN1257186C (fr)
BG (1) BG108256A (fr)
BR (1) BR0208596A (fr)
CA (1) CA2443277A1 (fr)
HK (1) HK1069834A1 (fr)
HU (1) HUP0303645A3 (fr)
IL (1) IL157896A0 (fr)
MX (1) MXPA03009082A (fr)
NO (1) NO20034432L (fr)
NZ (1) NZ528651A (fr)
PL (1) PL366705A1 (fr)
WO (1) WO2002081507A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023182947A1 (fr) * 2022-03-22 2023-09-28 Chiang Mai University Protéine modifiée d'interféron gamma et son utilisation
TWI868594B (zh) 2022-03-22 2025-01-01 清邁大學 經修飾的干擾素γ蛋白質和其用途

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2525647A1 (fr) 2003-05-16 2005-02-24 Intermune, Inc. Ligands des recepteurs des chimiokines synthetiques et leurs methodes d'utilisation
JP4707327B2 (ja) * 2004-01-27 2011-06-22 旭化成ファーマ株式会社 ポリペプタイド類の吸着防止剤
US7597884B2 (en) 2004-08-09 2009-10-06 Alios Biopharma, Inc. Hyperglycosylated polypeptide variants and methods of use
JP2008513356A (ja) * 2004-08-09 2008-05-01 アリオス バイオファーマ インク． 合成高度糖鎖付加プロテアーゼ耐性ポリペプチド変異体、それを使用する経口製剤および方法
CN103550757A (zh) * 2005-09-20 2014-02-05 纽约大学 用干扰素治疗肺病的方法
US7625555B2 (en) 2007-06-18 2009-12-01 Novagen Holding Corporation Recombinant human interferon-like proteins
JP5769142B2 (ja) * 2007-09-04 2015-08-26 独立行政法人酒類総合研究所 ピヒア属酵母において異種タンパク質を高分泌させる方法
EP2039764A1 (fr) * 2007-09-19 2009-03-25 Pevion Biotech AG Protéinase aspartyl à sécrétoire tronqué 2
BG66517B1 (bg) 2008-04-08 2016-02-29 Tigo Gmbh Супресор на ендогенния човешки гама - интерферон
RU2446821C2 (ru) * 2010-07-15 2012-04-10 Олег Ильич Эпштейн Лекарственное средство для лечения инфекционных заболеваний, сопровождающихся нейротоксическими нарушениями, и способ лечения инфекционных заболеваний, сопровождающихся нейротоксическими нарушениями
GB201621728D0 (en) 2016-12-20 2017-02-01 Ucb Biopharma Sprl Methods
BG67190B1 (bg) 2017-03-29 2020-11-16 Tigo Gmbh Анти-гама мутантен протеин срещу ендогенния човешки гама интерферон

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX9203641A (es) * 1983-12-16 1992-07-01 Genentech Inc Interferones gamma recombinantes que poseen estabilidad mejorada y metodos biotecnologicos para su obtencion.
BG52073B2 (en) * 1990-01-24 1996-04-30 Inst Molekuljarna Biolog Method for the preparation of recombinant human noncystein -interferon, free of n-end methionine
DE4036856C1 (fr) * 1990-11-19 1992-05-27 Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung Ev, 8000 Muenchen, De

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023182947A1 (fr) * 2022-03-22 2023-09-28 Chiang Mai University Protéine modifiée d'interféron gamma et son utilisation
TWI868594B (zh) 2022-03-22 2025-01-01 清邁大學 經修飾的干擾素γ蛋白質和其用途

Also Published As

Publication number Publication date
BG108256A (bg) 2004-12-30
CN1257186C (zh) 2006-05-24
NO20034432L (no) 2003-10-29
PL366705A1 (en) 2005-02-07
HUP0303645A2 (hu) 2004-01-28
HK1069834A1 (en) 2005-06-03
IL157896A0 (en) 2004-03-28
MXPA03009082A (es) 2004-11-22
BR0208596A (pt) 2004-03-09
NO20034432D0 (no) 2003-10-03
WO2002081507A3 (fr) 2004-02-12
JP2005518183A (ja) 2005-06-23
NZ528651A (en) 2006-06-30
EP1412382A2 (fr) 2004-04-28
HUP0303645A3 (en) 2005-12-28
KR20030094336A (ko) 2003-12-11
WO2002081507A2 (fr) 2002-10-17
CN1537117A (zh) 2004-10-13

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued