CA2391416A1 - Oncolytic combinations for the treatment of cancer - Google Patents

Abstract

Leukotriene (LTB4) antagonists enhance the effectiveness of 2',2'- difluoronucleoside anti-cancer agents.

Description

ONCOLYTIC COMBINATIONS FOR THE TREATMENT OF CANCER
CROSS REFERENCE TO RELATED APPLICATION
This application claims priority from United States Provisional Patent Application No. 60/164,786 filed 11 November 1999; the entire disclosure of which is incorporated herein by reference.
FIELD OF THE INVENTION
This invention relates to a method of treating cancer with anti-cancer agents. More specifically, it relates to the use of 2',2'-difluoronucleoside anti-cancer agents, in conjunction with leukotriene (LTB4) antagonists which enhance the effectiveness of the anti-cancer agent.
BACKGROUND OF THE INVENTION
Leukotriene B4 (LTB4) is a proinflammatory lipid which has been implicated in the pathogenesis of psoriasis, arthritis, chronic lung diseases, acute respiratory distress syndrome, shock, asthma, inflammatory bone diseases and other inflammatory states characterized by the infiltration and activation of polymorphonuclear leukocytes and other proinflammatory cells. Thus activated, the polymorphonuclear leukocytes liberate tissue-degrading enzymes and reactive chemicals causing the inflammation. US Patent 5,462,954 discloses phenylphenol leukotriene antagonists that are useful in the treatment of psoriasis, arthritis, chronic lung diseases, acute respiratory distress syndrome, shock, asthma, inflammatory bone diseases and other inflammatory states characterized by the infiltration and activation of polymorphonuclear leukocytes and other proinflammatory cells. US Patent 5,910,505 discloses that certain phenylphenol leukotriene B4 (LTB4) antagonists are useful as agents for the treatment of oral squamous cell carcinoma. US Patent 5,543,428 discloses a group of phenylphenol leukotriene antagonists which have the property of reversing multi drug resistance in tumor cells. The use of the leukotriene antagonist will reverse the drug resistance of resistant tumor cells to vinblasine, vincristine, vindesine, navelbine, daunorubicin, doxorubicin, mitoxantrone, etoposide, teniposide, mitomycin C, actinomycin, taxol, topotecan, mithramycin, colchicine, puromycin, podophylotoxin, emetine, gramicidin, and valinomycin.
2 0 BRIEF SUN~A,RY OF THE INVENTION
This invention provides compositions and methods useful for treating cancers, in particular, cancers that are not multi drug resistant. The methods of the present invention include the 2',2'-difluoronucleoside anti-cancer agents described in US Patent 5,464,826 in combination with leukotriene (LTB4) antagonists of formula A, formula I and formula II, described below.
Surprisingly, we have found that the combination of 2',2'-difluoro nucleoside anti-cancer agents with leukotriene (LTB4) antagonists act synergistically against cancers which are not multi-drug resistant.
The types of cancers that may be treated with the compositions of the present invention include: Breast Carcinoma, Bladder Carcinoma, Colorectal Carcinoma, Esophageal Carcinoma, Gastric Carcinoma, Germ Cell Carcinoma e.g. Testicular Cancer, Gynecologic Carcinoma, Lymphoma Hodgkin's, Lymphoma - Non-Hodgkin's, Malignant Melanoma, Multiple Myeloma, Neurologic Carcinoma, Brain Cancer, Pancreatic Carcinoma, Prostate Carcinoma, Ewings Sarcoma, Osteosarcoma, Soft Tissue Sarcoma, Non-Small Cell Lung Cancer, Pediatric Malignancies and the like.
BRIEF DESCRIPTION OF THE DRAWINGS
Figures 1 through 6 are horizontal bar graphs displaying the data of Tables 1 through 6 provided in the "ASSAY EXAMPLE 1", infra. The vertical axis of the graph in each Figure forms the origin of the numbered horizontal bars, wherein each bar is a separate Treatment as set out in the Tables. The horizontal axis is tumor growth delay (TGD) in days.
DETAILED DESCRIPTION OF THE INVENTION
I. Definitions:
The term, "Acidic Group" means an organic group which when attached as the "Z" substituent of formula (I) or the "Z2" substituent of formula (II) acts as a proton donor capable of hydrogen bonding. An illustrative acidic group is carboxyl.

The term, "Active Ingredient" refers both to certain 2', 2'-difluoronucleoside compounds and also leukotriene B4 antagonist compounds generically described by formula A as well as diphenyl leukotriene Bg antagonist compounds generically described by formula I and formula II or the list of specific diphenyl compounds disclosed, infra., as well as a combination of a 2', 2'-difluoronucleoside and a leukotriene B4 antagonist described by formula A or formulas I and/or II, and the salts, solvates, and prodrugs of such compounds.
The term, "alkenyl" means a monovalent radical of the generic formula CnH2n such as ethenyl, n-propenyl, isopropeneyl, n-butenyl, isobutenyl, 2-butenyl, and 3-butenyl.
The term, "alkyl" by itself or as part of another substituent means, unless otherwise defined, a straight or branched chain monovalent hydrocarbon radical such as methyl, ethyl, n-propyl, isopropyl, n-butyl, tertiary butyl, sec-butyl, n-pentyl, and n-hexyl.
The term, "alkaryl" means an aryl radical substituted with an alkyl or substituted aryl group, for example:
In the term, "C6-C20 alkaryl" the numerical subscripts refer to the total number of carbon atoms in the radical.

The term, "C6-C20 aralkyl" means an alkyl radical substituted with an aryl or substituted aryl group, for example:
H3C, In the term, "C6-C20 aralkyl" the numerical subscripts refer to the total number of carbon atoms in the radical.
The term, "carbocyclic group" refers to a five, six, seven, or eight membered saturated, unsaturated or aromatic ring containing only carbon and hydrogen (e. g., benzene, cyclohexene, cyclohexane, cyclopentane).
The term, "cycloalkyl" means a carbocyclic non-aromatic monovalent radical such as cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, and cyclooctyl.
The term, "halo" means fluoro, chloro, bromo, or iodo.
The term, "heterocyclic radical(s)" refers to a radical having a saturated, unsaturated or aromatic five membered substituted or unsubstituted ring containing from 1 to 4 hetero atoms.
The terms, "mammal" and "mammalian" include human.
The term, "N-sulfonamidyl" means the radical:

II " II
O O
where R12 is C1-C10 alkyl, aryl, C1-C6 alkyl substituted aryl, C6-C20 alkaryl, or C6-C20 aralkyl.
The term, "substituted alkyl" means an alkyl group further substituted with one or more radicals) selected from halo, C1-C6 alkyl, aryl, benzyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-Cg cycloalkyl, C1-Cg alkoxy, C1-C6 haloalkyl (e. g., -CF3).
The term, "substituted aryl" means an aryl group further substituted with one or more radicals) selected from halo, C1-C6 alkyl, aryl, benzyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-Cg cycloalkyl, C1-Cg alkoxy, C1-C6 haloalkyl (e. g., -CF3).
The term, "tetrazolyl" refers to an acidic group represented by either of the formulae:
N N HN N
N~ NH N~ N
The term "therapeutically effective interval" is a period of time beginning when one of either (a) the 2', 2'-difluoronuceoside anti-cancer agent or (b) the LTBg antagonist is administered to a mammal and ending at the limit of the anti-cancer beneficial effect in treating cancer of (a) or (b). Typically, the anti-cancer agents and the leukotriene (LTB4) antagonist are administered within 24 hours of each other, more preferably within 4 hours and most preferably within 1 hour.
The phrase "therapeutically effective combination", used in the practice of this invention, means administration of both (a) the 2', 2'-difluoronuceoside anti-cancer agent and (b) the LTB4 antagonist, either simultaneously or separately, in any order.
The anti cancer agents which may be used are 2',2'-difluoronucleoside compounds of the formula:
R'O -H2C O

F
OH F
wherein:
R2 is hydrogen or ~C-Rs R2 is a base defined by one of the formulae -g-NHRg N~X H N N
R3 HN~ N N
~J
H
V
HN /\
HN X
O~N~\N~ ~ N
H I

N I
X is N or C-R4 R3 is hydrogen, C1-Cg alkyl or ~C-Rs R4 is hydrogen, C1-Cg alkyl, amino, bromo, fluoro, chloro or iodo;
Each R5 independently is hydrogen or C1-C4 alkyl; and the pharmaceutically-acceptable salts thereof.
The following compounds may also be used R' F
OH F
wherein:
R6 is hydrogen, C1-C4 alkyl;
R~ is a base of one of the formulae NHRB O
N~X H N ~
RB HN~N N/
I

H RB
J ~ ~N>
N I R N I N
X is N or C-R4;
R8 is hydrogen or C1-C4 alkyl;
R4 is hydrogen, C1-C4 alkyl; amino, bromo, fluoro, chloro and iodo; and the pharmaceutically-acceptable salts thereof;
with the proviso that R6 and R8 may both be hydrogen only when x is N and R6 O _ H2C O

F
OH F
wherein:
R6 is hydrogen or C1-C4 alkyl;
O
R9is HN
N /I N
H I

These compounds are disclosed in US Patent 5,464,826 which is incorporated by reference herein for its disclosure of the methods of preparing these compounds, formulating these compounds, and the treatment of cancer using these compounds.
Alternatively, preferred 2'2'-difluoronucleoside compounds are compounds represented by the formula:
R, O R2 F
where:
R1 is hydrogen;
Rz is a base defined by one of the formulae:

N ~~X HN
N
O N ~ R3HN N

HN N ~ N
N
O N N .

X is C-R4;
R3 is hydrogen;
R4 is hydrogen, C1-C4 alkyl, bromo, fluoro, chloro or iodo;
and pharmaceutically acceptable salts thereof.
More preferably the compounds are whereRz is the base defined by the formula:

N ~\X
~N
O
Even more preferred are anti-cancer agents are selected from the group consisting of the following compounds or a pharmaceutically acceptable salt thereof:
(i) 1-(4-amino-2-oxo-1H-pyrimidin-1-yl)-2-desoxy-2',2'-difluororibose, (ii) 1-(4-amino-2-oxo-1H-pyrimidin-1-yl)-2-desoxy-2',2'-difluoroxylose, (iii) 1-(2,4-dioxo-1H,3H-pyrimidin-1-yl)-2-desoxy-2',2'-difluororibose, and (iv) 1-(4-amino-5-methyl-2-oxo-1H-pyrimidin-1-yl)-2-desoxy-2',2'-difluororibose.
The most preferred compound is gemcitabine HC1 which is a nucleoside analogue that exhibits antitumor activity.
Gemcitabine HC1 is 2'-deoxy-2',2'-difluorocytidine monohydrochloride ((3-isomer), also known as 2',2'-difluoro-2'-deoxycytidine monohydrochloride, or also as 1-(4-amino-2-oxo-1H-pyrimidin-1-yl)-2-desoxy-2',2'-difluororibose.
The structural formula is as follows:
NHZ HCI
~~ N
HO
,O_ H
~H
The anti-cancer agents are generally mixed with a carrier which may act as a diluent, or excipient the anti-cancer agents may be administered in the form of tablets, pills, powders lozenges, sachets, cachets, elixirs, suspensions, emulsion, solution, syrups or aerosols.
Sterile injectable solutions may also be used.

The leukotriene (LTB4) antagonists useful in the present invention include those given in formula A.
X'-Y'-Z'-A'-RQ' R3.
R1~
Formula A
or a pharmaceutically acceptable base addition salt thereof, wherein:
R1' is C1-C5 alkyl, C2-C5 alkenyl, C2-C5 alkynyl, C1-C4 alkoxy, (C1-C4 alkyl)thio, halo, or R2'-substituted phenyl;
each R2' and R3' are each independently hydrogen, halo, hydroxy, C1-C4 alkyl, C1-C4 alkoxy, (C1-C4 alkyl)-(0)q S-, trifluoromethyl, or di-(C1-C3 alkyl)amino;
X' is -O-, -S-, -C(=O), or -CH2-;
Y' is -O- or -CH2-;
or when taken together, -X'-Y'- is -CH=CH- or -C=C-;
Z' is a straight or branched chain C1-C1p alkylidenyl;
A' is a bond, -0-, -S-, -CH=CH-, or -CRaRy~-, where Ra and Rb are each independently hydrogen, C1-C5 alkyl, or R~~-substituted phenyl, or when taken together with the carbon atom to which they are attached form a C4-Cg cycloalkyl ring;
R4' is R6 R~
R~
I OGRs -O
R
(K)P'W'Rs (CH2)t c R» , R~
W'Rs T
R~
Rg UV-Rs T
R~
W_Rs R~
where each R6 is independently -COON, 5-tetrazolyl, CON(R9)2, or -CONHS02R10%
each R~ is hydrogen, C1-C4 alkyl, C2-C5 alkenyl, C2-C5 alkynyl, benzyl, methoxy, -W-R6, -T-G-R6, (C1-C4 alkyl)-T-(C1-Cg alkylidenyl)-O-, or hydroxy;
Rg is hydrogen or halo;
each R9 is independently hydrogen, phenyl, or C1-C4 alkyl, or when taken together with the nitrogen atom form a morpholino, piperidino, piperazino, or pyrrolidino group;
R10 is C1-C4 alkyl or phenyl;
R11 is R2, -W-R6, or -T-G-R(;
each W is a bond or a straight or branched chain divalent hydrocarbyl radical of one to eight carbon atoms;
each G is a straight or branched chain divalent hydrocarbyl radical of one to eight carbon atoms;
each T is a bond, -CH2-, -0-, -NH-, -NHCO-, -C(=O)-, or (O) q S-;
K is -C(=0)- or -CH(OH)-;
each q is independently 0, 1, or 2;
p is 0 or 1; and t is 0 or 1;
provided when X is -O- or -S-, Y is not -O-;
provided when A is -O- or -S-, R4' is not R6;
and provided W is not a bond when p is 0.
Preferred LTB4 antagonists of Formula A are those compounds wherein R4' is selected from the following formulae:

R~~
R~
or - Rs An even more preferred LTBg antagonist of Formula A are those compounds-wherein R4' is:
- Rs Some of these preferred LTBg antagonist compounds or pharmaceutically acceptable acid or salt derivatives thereof are listed herein from the group (A) to (KKKK) consisting of A) 2-Methyl-2-(1H-tetrazol-5-yl)-7-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)heptane;
B) 2-Methyl-2-(1H-tetrazol-5-yl)-7-(2-ethyl-4-(3-fluorophenyl)-5-hydroxyphenoxy)heptane;

C) 3-(2-(3-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)-6-(4-dimethylaminocarbonylbutyloxy)phenyl)propion is acid;
D) 3-(2-(3-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)phenyl)propionic acid;
E) 3-(2-(3-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)-6-(4-carboxybutyloxy)phenyl)propionic acid;
F) 3-(2-(3-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)-6-methoxyphenyl)propionic acid;
G) 3-(2-(3-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)-6-(4-(1H-tetrazol-5-yl)butyloxy)phenyl)propionic acid;
H) Methyl 3-(2-(4-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)-(1-butenyl))phenyl)propionate;
I) 3-(2-(4-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)-(1-butenyl))phenyl)propionic acid;
J) 3-(2-(4-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)butyl)phenyl)propionic acid;
K) 3-(2-(4-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)butyl)-6-methoxyphenyl)propionic acid;
L) Methyl 3-(2-(3-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)-6-hydroxyphenyl)propionate;
M) 3-(2-(3-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)-6-hydroxyphenyl)propionic acid;
N) 3-(2-(3-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)-6-(4-butyloxy)phenyl)propionic acid;

O) 3-(2-(3-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)-6-(4-methylthiobutyloxy)phenyl)propionic acid;
P) 3-(2-(3-(2,4-Di(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)-6-(4-carboxybutoxy)phenyl)propionic acid;
Q) 6-Methyl-6-(1H-tetrazol-5-yl)-11-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)undecane;
R) N,N-Dimethyl-3-(2-(3-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)phenyl)propionamide;
S) N-Methanesulfonyl-3-(2-(3-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy).phenyl)propionamide;
T) N-Phenylsulfonyl-3-(2-(3-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)phenyl)propionamide;
U) 3-(2-(3-(2-Butyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)phenyl)propionic acid;
V) Ethyl 3-(2-(4-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)butyloxy)phenyl)propionate;
W) 3-(2-(4-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)butyloxy)phenyl)propionic acid;
X) Methyl 3-(2-(3-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)-6-(4-(methoxycarbonyl)phenoxy)phenyl)propionate;
Y) 3-(2-(3-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)-6-(4-carboxyphenoxy)phenyl)propionic acid;
z) 3-(2-(3-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)-4-(4-carboxyphenoxy)phenyl)propionic acid;

AA) 3,3-Dimethyl-3-(2-(3-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)phenyl)propionic acid;
BB) 2-Methyl-2-(1H-tetrazol-5-yl)-3-(2-(3-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)phenyl)propane;
CC) 2-Methyl-2-(1H-tetrazol-5-yl)-3-hydroxy-3-(2-(3-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)phenyl)propane;
DD) 3-(2-(3-(2-Bromo-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)phenyl)propionic acid;
EE) 3-(2-(3-(2-Ethylthio-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)phenyl)propionic acid;
FF) Methyl 3-(2-hydroxy-3-(4-methoxycarbonylbutyl)-6-(3-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)phenyl)propionate;
GG) 5-(3-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)-8-(4-carboxybuty 1)dihydrocoumarin;
HH) 2-Phenyl-4-ethyl-5-[6-(2H-tetrazol-5-yl)-6-methylheptyloxy]phenol sodium salt;
II) 2-(4-Methylphenyl)-4-ethyl-5-[6-methyl-6-(2H-tetrazol-5-yl)heptyloxy]phenol disodium salt;
JJ) 2-(3-Methylphenyl)-4-ethyl-5-[6-methyl-6 (2H-tetrazol-5-yl)heptyloxy]phenol sodium salt;
KK) 2-(2-Methylphenyl)-4-ethyl-5-[6-methyl-6-(2H-tetrazol-5-yl)heptyloxy]phenol disodium salt;
LL) 2-(4-Methoxyphenyl)-4-ethyl-5-[6-methyl-6-(2H-tetrazol-5-yl)heptyloxy]phenol sodium salt;

MM) 2-(3-Methoxyphenyl)-4-ethyl-5-[6-methyl-6-(2H-tetrazol-5-yl)heptyloxy]phenol sodium salt;
NN) 2-(4-Trifluoromethylphenyl)-4-ethyl-5-[6-methyl-6-(2H-tetrazol-5-yl)heptyloxy]phenol disodium salt;
00) 2-(3-Dimethylaminophenyl)-4-ethyl-5-[6-methyl-6-(2H-tetrazol-5-yl)heptyloxy]phenol disodium salt;
PP) 3-(5-(6-(4-Phenyl-5-hydroxy-2-ethylphenoxy)propoxy)-2-carboxymethyl-1,2,3,4 -tetrahydronaphthalen-1(2H)-one)propanoic acid;
QQ) 3-(5-(6-(4-(4-Fluorophenyl)-5-hydroxy-2-ethylphenoxy)propoxy)-2-carboxymeth yl-1,2,3,4-tetrahydronaphthalen-1(2H)-one)propanoic acid;
RR) 3-(4-(5-(4-(4-Fluorophenyl)-5-hydroxy-2-ethylphenoxy)propoxy)-2-carboxymeth yl-2,3-dihydroinden-1(2H)-one)propanoic acid;
SS) 3,3-Dimethyl-5-(3-(2-carboxyethyl)-4-(3-(4-fluorophenyl)-5-hydroxy-2-ethylphenoxy)propoxy)phenyl)-5-oxopentanoic acid;
TT) 7-[3-[(5-Ethyl-2-hydroxy[1,1'-biphenyl]-4 yl)oxy]propoxy]-3,4-dihydro-8-propyl-2H-1 benzopyran-2-carboxylic acid;
UU) 8-Propyl-7-[3-[4-(4-fluorophenyl)-2-ethyl-5-hydroxyphenoxy]propoxy]-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid;
W) 2-[3-[3-[(5-Ethyl-2-hydroxy[1,1'-biphenyl]-4-yl)oxy]propoxy]-2-propylphenoxy]propanoic acid;
WW) 2-(4-Chlorophenyl)-4-ethyl-5-[6-methyl-6-(2H-tetrazol-5-yl)heptyloxy]phenol monosodium salt;

XX) 2-(3,5-Dichlorophenyl)-4-ethyl-5-[6-methyl-6-(2H-tetrazol-5-yl)heptyloxy]phenol monosodium salt;
YY) 3-[2-[3-[(5-Ethyl-2-hydroxy[1,1'-biphenyl]-4-yl)oxy]propoxy]-1-dibenzofuran]propanoic acid disodium salt;
ZZ) 7-Carboxy-9-oxo-3-[3-(2-ethyl-5-hydroxy-4-phenylphenoxy)propoxy]-9H-xanthene-4-propanoic acid disodium salt monohydrate;
AA.A) 2-[2-Propyl-3-[3-(2-ethyl-5-hydroxy-4-phenylphenoxy)propoxy]phenoxy]benzoic acid sodium salt hemihydrate;
BBB) 3-[3-(2-Ethyl-5-hydroxy-4-phenylphenoxy)propoxy][1,1'-biphenyl]-4-propanoic acid disodium salt monohydrate;
CCC) 5-Ethyl-4-[3-[2-propyl-3-[2-(2H-tetrazol-5-yl)phenoxy]phenoxy]propoxy][1,1'-biphenyl]-2-0l disodium salt sesquihydrate;
DDD) 3-[4-[3-[ 3-(2-Ethyl-5-hydroxy-4-phenylphenoxy)propoxy]-9-oxo-9H-xanthene]]propanoic acid sodium salt hemihydrate;
EEE) 2-Fluoro-6-[2-propyl-3-[3-(2-ethyl-5-hydroxy-4-phenylphenoxy)propoxy]phenoxy]benzoic acid disodium salt;
FFF) 2-[2-Propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]phenoxy]benzoic acid sodium salt;
GGG) 3-[4-[7-Carboxy-9-oxo-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]-9H-xanthene]] propanoic acid disodium salt trihydrate;
HHH) 3-[4-[9-Oxo-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]-9H-xanthene]]propanoic acid;

III) 3-[2-[1-[2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]-4-(5-oxo-5-morpholinopentanamido)phenyl]propanoic acid;
JJJ) 2-Fluoro-6-[2-propyl-3-[3-[2-ethyl-5-hydroxy-4-(4-fluorophenyl)phenoxy]propoxy]phenoxy]benzoic acid disodium salt hydrate;
KKK) 4-Fluoro-2-[2-propyl-3-[3-[2-ethyl-5-hydroxy-4-(4-fluorophenyl)phenoxy]propoxy]phenoxy]benzoic acid;
LLL) 2-[2-Propyl-3-[5-[2-ethyl-5-hydroxy-4-(4-fluorophenyl)phenoxy]pentoxy]phenoxy]benzoic acid;
MMM) 2-[2-Propyl-3-[4-[2-ethyl-5-hydroxy-4-(4-fluorophenyl)phenoxy]butoxy]phenoxy]benzoic acid sesquihydrate;
NNN) 2-[2-(2-Methylpropyl)-3-[3-[2-ethyl-5-hydroxy-4-(4-fluorophenyl)phenoxy]propoxy]phenoxy]benzoic acid;
000) 2-[2-Butyl-3-[3-[2-ethyl-5-hydroxy-4-(4-fluorophenyl)phenoxy]propoxy]phenoxy]benzoic acid hydrate;
PPP) 2-[2-(Phenylmethyl)-3-[3-[2-ethyl-5-hydroxy-4-(4-fluorophenyl)phenoxy]propoxy]phenoxy]benzoic acid;
QQQ) 2-[2-Propyl-3-[3-[2-ethyl-5-hydroxy-4-(4-fluorophenyl)phenoxy]propoxy]phenoxy]phenyla cetic acid;
RRR) 2-[2-Propyl-3-[3-[2-ethyl-5-hydroxy-4-(4-fluorophenyl)phenoxy]propoxy]benzoyl]benzoic acid;
SSS) 2-[[2-Propyl-3-[3-[2-ethyl-5-hydroxy-4-(4-fluorophenyl)phenoxy]propoxy]phenyl]methyl]b enzoic acid;

TTT) 2-[2-Propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]thiophenoxy]benzoic acid;
UUU) 2-[2-Propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]phenylsulfinyl]benzoi c acid;
VW) 2-[2-Propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]phenylsulfonyl]benzoi c acid hydrate;
WWW) 5-[3-[2-(1-Carboxy)ethyl]-4-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]phenyl]-4-pentynoic acid disodium salt 0.4 hydrate;
XXX) 1-Phenyl-1-(1H-tetrazol-5-yl)-6-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)hexane;
YYY) 1-(4-(Carboxymethoxy)phenyl)-1-(1H-tetrazol-5-yl)-6-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)hexane;
ZZZ) 1-(4-(Dimethylaminocarbonylmethoxy)phenyl) 1-(1H-tetrazol-5-yl)-6-(2-ethyl-4-(4 fluorophenyl)-5-hydroxyphenoxy)hexane;
AAAA) 3-(2-(3-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)phenyl)-E-propenoic acid;
BBBB) 3-(2-(3-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)phenyl)-2-methyl-E-propenoic acid;
CCCC) 5-(2-(2-(3-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)phenyl)ethyl)-1H-tetrazole;
DDDD) 3-(2-(3-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)-4-(4-carboxybutyloxy)phenyl)propionic acid;

EEEE) 5-[3-[4-(4-Fluorophenyl)-2-ethyl-5-hydroxyphenoxy]propoxy]-3,4-dihydro-2H-1-benzopyran-2-one;
FFFF) 3-(3-{3-[2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenyloxy]propoxy}phenyl)propanoic acid;
GGGG) 3-(3-{3-[2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenyloxy]propoxy}-4-propylphenyl)propanoic acid sodium salt;
HHHH) 3-(4-{3-[2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenyloxy]propoxy}-3-propylphenyl)propanoic acid;
IIII) 3-(3-{3-[2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenyloxy]propoxy}-2-propylphenyl)propanoic acid;

JJJJ) 3-{3-[3-(2-Ethyl-5-hydroxyphenyloxy)propoxy]-2-propylphenyl}propanoic acid disodium salt;
and KKKK) 2-[3-[3-[2-Ethyl-5-hydroxy-4-(4-fluorophenyl)phenoxy]propoxy]benzoyl]benzoic acid disodium salt hemihydrate.
These leukotriene (LTB4) antagonists are well known in the art, and are fully described in U.S. Patent 5,462,954, which is hereby specifically incorporated by reference for its disclosure of the methods of preparation of specific leukotriene B4 antagonists and compounds or formulations of the leukotriene antagonists which may be administered to patients. A preferred compound is 2-[2-propyl-3-[3-[2-ethyl-5-hydroxy-4-(4-flourophenyl)phenoxy]propoxy]phenoxy benzoic acid which can also be named 2-[3-[3-(5-ethyl-4'-flouro-2-hydroxybiphen-4-yloxy)propoxy-2-propylphenoxy]benzoic acid, described in U.S. Patent 5,462,954 as example 66 and also shown below as Compound A
(Formula B):

A second class of LTB4 antagonists to use as the essential co-agent in the compositions and practice of the method of this invention are those disclosed in copending provisional patent application, titled, "Heterocycle Substituted biphenyl Leukotriene Antagonists" (inventor, Jason Scott Sawyer) containing 97 pages and identified as Eli Lilly and Company Docket No. B-13240), filed on November 11, 1999, and now Provisional patent Application Serial Number 60/164,786. This second class of heterocycle substituted diphenyl leukotriene antagonists are described in more detail below:
II. Additional LTB4 Antagonists:
Additional LTB4 antagonists are described below which are novel heterocyclic substituted Biphenyl compounds of formula (I) Compound A (Formula B) X "

Y~H
2 n Yz Y~

(I~
wherein:
X is selected from the group consisting of, (i) a five membered substituted or unsubstituted heterocyclic radical containing from 1 to 4 hetero atoms independently selected from sulfur, nitrogen or oxygen; or (ii) a fused bicyclic radical wherein a carbocyclic group is fused to two adjacent carbon atoms of the five membered heterocyclic radical, (i);
Y1 is a bond or divalent linking group containing 1 to 9 atoms;
Y2 and Y3 are divalent linking groups independently selected from -CH2-, -0-, and -S-;
Z is an Acidic Group;
R1 is C1-C10 alkyl, aryl, C3-C10 cycloalkyl, C2-C10 alkenyl, C2-C10 alkynyl, C6-C20 aralkyl, C6-C20 alkaryl, C1-C10 haloalkyl, C6-C20 aryloxy, or C1-C10 alkoxy;

R2 is hydrogen, halogen, C1-Clp haloalkyl, C1-Clp alkoxy, C1-C1p alkyl, C3-Cg cycloalkyl, Acidic Group, or -(CH2)1_~(Acidic Group);
R3 is hydrogen, halogen, C1-C1p alkyl, aryl, C1-C10 haloalkyl, C1-Clp alkoxy, C1-C1p aryloxy, C3-Cg cycloalkyl;
R4 is C1-Cg alkyl, C3-Cg cycloalkyl, -(CH2)1-~(cycloalkyl), C2-C4 alkenyl, C2-C4 alkynyl, benzyl, or aryl; and n is 0, 1, 2, 3, 4, 5, or 6;
or a pharmaceutically acceptable salt, solvate, or prodrug derivative thereof.
III. Preferred LTBg Antagonists include the following:
III A. Preferred X substituents:
A "substituted heterocyclic radical" is preferably substituted with from 1 to 3 groups independently selected from hydrogen, halo, C1-C1p alkyl, C1-C1p haloalkyl, C1-C10 alkoxy, aryl, or C6-C2p aryloxy.
Preferred Group 1 of X substituent (symbol, "PG1-X") Preferred LTBg antagonist compounds used in the composition of the invention are those wherein X is a heterocyclic radical selected from the group consisting of substituents represented by the following structural formulae:

R11 ~ R11 ~ R11 O ~ S ~ N

N R11 ~ N R11 R11 ~N
O ~ S ~ O/
R11 ~ R11 ~-N R11 N N , S/ ~ N/ ~ O/

N R11 ~R11 N
N ~ N
S ~ N/ ~ N/

N R11 ~~R11 ~~R11 N/ , N/N ' N 1\S/N

~R11 N
N N N ~ N
> >
S/ \O/ O/
~R11 ~R11 N~R11 N ~ N ~ N
S/ O~ S/
> >

N N N/
\ ~ \\
N~S/N ~ N\O/N ~ N R11 O/ ' S/ ' N/
H

J
N
and ~ .

where R10 is a radical selected from hydrogen or C1-Cg alkyl; and R11 is a radical selected from hydrogen, halo, C1-C10 alkyl, C1-C10 haloalkyl, C1-C10 alkoxy, aryl, or C6-C20 aryloxy. Preferred R10 groups are hydrogen, methyl, or phenyl. Moreover, any of the above heterocyclic radicals illustrated by structural formulae may attach to the diphenyl leukotriene antagonist of formulae (I) by any monovalent bond originating on a suitable carbon or nitrogen atom in its ring structure.
For example, the pyrrole radical may attach to the diphenyl molecule by a single bond originating at any carbon atom or any nitrogen atom which has less than three bonds in the heterocyclic ring;
Location of attachment bond for pyrrole, I
A preferred form of the substituent X is a fused bicyclic radical wherein a carbocyclic group is fused to two adjacent carbon atoms of the five membered heterocyclic radical, for example:
N
and H
III B. Preferred Group 2 of X substituent (symbol, "PG2-X"):
Most preferred as the X substituents are the heterocyclic radicals;

N S

or _~
III C. Excluded X substituents:
The heterocyclic radical X of Formula (I) does not include 3-bromo-1,2,4 thiadiazole since the LTB4 antagonist activity of compounds containing this radical is considered too low to be an aspect of this invention.
III D. Preferred Y1 substituents:
Y1 is a bond or divalent linking group containing 1 to 9 atoms independently selected from carbon, hydrogen, sulfur, nitrogen, and oxygen;
Preferred Group 1 of Y1 substituent (symbol, "PG1-Y1") Preferred LTB4 compounds included in the composition of the invention are those wherein Y1 is a divalent linking group selected from the group consisting of substituents represented by the following formulae:

O , S , S02 , O
S S N-O ~ O
N C
R13 ' O ' C C
H2 H2 ' O~
H2 ' z N C , Hz O
C
Hz O and C C

O
where R13 is hydrogen, methyl, or ethyl;

The above divalent groups may be used in their forward or reversed positions. For example, the group;
C C

' O

may be positioned as either, Z or in the displayed fragment of formula (I).
III E. Preferred Group 2 of Y1 substituent (symbol, "PG2-y1" ) The most preferred divalent Y1 substituent is the group;
O
III F. Preferred Group 1 of Yz substituent (symbol, "PG1-YZ") and Preferred Group 1 of Y3 substituent (symbol, "PG1-Y3 " ) The Y2 and Y3 substituents are preferably selected from -S- and -O-.

III G. Preferred Group 2 of YZ substituent (symbol, "PG2-YZ") and Preferred Group 2 of Y3 substituent (symbol, "PG2-Y3" ) Most preferably both Y2 and Y3 are the group;
O
III H. Preferred Group 1 of Z substituent (symbol, "PG1-Z"):
Z is the Acidic Group as previously defined. Preferred is an acidic group selected from the following:

II
O O
tetrazolyl, -S03H, O

OH

P , OH

O

OH

O P

OH

C OH or HO
N
where R12 is C1-C10 alkyl, aryl, C6-C20 alkaryl, or C6-C20 aralkyl. Preferred R12 groups are represented by the formulae:

and III I. Preferred Group 2 of Z substituent (symbol, "PG2-Z"):
Highly preferred are the acidic groups; -5-tetrazolyl, N-acyl sulfonamide, -S03H, and carboxyl.
III J. Preferred Group 3 of Z substituent (symbol, "PG3-Z"):
Carboxyl is the most preferred Z substituent.
III K. Preferred Group 1 of n subscript variable (symbol, "PG1-n") The most preferred integer values for the divalent linking group, -(CH2)n- , are n=1, n=2, and n=3.
III L. Preferred Group 2 of n subscript variable (symbol, "PG2-n") The most preferred integer value of n.for the divalent linking group, -(CH2)n- is n = 1.
III M. Preferred Group 1 of R1 substituent (symbol, "PG1-R1"):
A preferred R1 group is methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, and 2-propenyl; with n-propyl being most preferred.
III N. Preferred Group 1 of R2 substituent (symbol, "PG1-R2")and Preferred Group 1 of R3 substituent (symbol, "PG1-R3"):
Preferred R2 and R3 groups are those wherein R2 and R3 are independently selected from hydrogen or methyl, ethyl, methoxy, ethoxy, halo, or -CF3; with R2 and R3 both being hydrogen as most preferred.
III O. Preferred Group 1 of R4 substituent (symbol, "PG1-R4":) Preferred R4 substituents are ethyl, propyl, and isopropyl.
III P. Combinations of substituents of the compound of Formula (I):
The substituents of formula (I) are defined as "Z", "X", "n", "R1", "R2", "R3", "R4", "Y1", "Y2", and "Y3".
Moreover, as described in the preceding section, within each of the defined substituents of Formula (I) are "preferred" and "most preferred" subgroups which define the variety of substituents to be used in the definition of LTB4 antagonists of the invention. These preferred subgroups are defined by designations such as "PG1-R4" as recited above. It is often advantageous to use combinations of preferred groups or combinations of preferred groups together with the general definition of variables given in Formula (I). Suitable combinations of substituents are shown in the following three Tables (viz., R-Table, Y-Table & XZn-Table).

The following R-Table is used to select combinations of general and preferred groupings of the variables R1, R2, R3 and R4 for substitution in formula (I), as follows:
R-Table R variables R1 R2 R3 R4 Combination group group group group Code choice choice choice choice Thus, for example, the substituent combination, "R14"
describes a substituent combinatorial choice for Formula (I) wherein R1 is selected from the preferred set of variables, "PG1-R1", that is, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, and 2-propenyl; the R2 substituent is selected from the preferred set of variables, "PG1-R2", that is, hydrogen or methyl, ethyl, methoxy, ethoxy, halo, or -CF3; the variable R3 has the scope defined in the generic formula (I), and the substituents suitable for R4 are selected from the preferred group, "PG1-R4" having the preferred set of variables, ethyl, propyl, and isopropyl.
The following Y-Table is used to select broad and preferred groupings of the variables Y1, Y2, and Y3 for substitution in formula (I), as follows:

Y-Table Y variables Y1 group Y2 group Y3 group combination choice choice choice code The following XZn-Table is used to select broad and preferred groupings of the variables X, Z, and n for substitution in formula (I), as follows:
XZn-Table XZn variables X Z n integer combination group Group group code choice Choice choice XZn01 X Z n XZn02 X Z PG1-n XZn03 X Z PG2-n XZn04 X PG1-Z n XZn05 X PG2-Z n XZn06 X PG3-Z n XZn07 X PG1-Z PG1-n XZn08 X PG2-Z PG1-n XZn09 X PG3-Z PG1-n XZnlO X PG1-Z PG2-n XZnl1 X PG2-Z PG2-n XZnl2 X PG3-Z PG2-n XZnl3 PG1-X Z n XZnl4 PG1-X Z PG1-n XZnl5 PG1-X Z PG2-n XZnl6 PG1-X PG1-Z n XZnl7 PG1-X PG2-Z n XZnl8 PG1-X PG3-Z n XZnl9 PG2-X PG1-Z PG1-n XZn20 PG2-X PG2-Z PG1-n XZn21 PG2-X PG3-Z PG1-n XZn22 PG2-X PG1-Z PG2-n XZn23 PG2-X PG2-Z PG2-n XZn24 PG2-X PG3-Z PG2-n How to Use the Tables:
Any of the individual 16 combinations of the R
substituents depicted in the R-Table may be used in combination with any of the 27 individual combinations of Y substituents depicted in the Y-Table, which may be used with any of the 24 combinations of XZn substituents depicted in the XZn-Table. For example, the substituent combination choice "R07, Y21, XZn03" defines substituent set selections for a subset of formula (I) useful in the practice of the composition and method of invention.
III Q. Additional preferred LTB4 antagonists are described by formula (II):

O

(II~
wherein;

X2 is a heterocyclic radical selected from, N S

or s~
R21 is ethyl, 2-propen-1-yl, 3-propen-1-yl, n-propyl, iso-propyl, n-butyl, sec-butyl, or tert-butyl; and R22 is hydrogen, n-butyl, sec-butyl, flouro, chloro, -CF3, or tert-butyl.
Z2 is carboxyl, tetrazolyl, N-sulfonamidyl.
Preferred Compounds of the Invention:
III R. Specific compounds preferred as LTB4 antagonist component of the composition and method of the invention are represented by the following structural formulae:
(C1) /=N OH
O ~
O~O ~ ~ O
COOH
(C2):

~HCI
H
~N~ OH
N ~
O ~\/~ O \
COOH
(C3) /=N OH
S ~
/
/ O~O \ O
COOH
(C4) N'N~~ ~ OH
/
/ O~O \ O \
COOH
(C5) N'O OH
\ / /
/ O~O \ I O \
COOH
(C6) ~N~N.H OH
N ~
\ / /
I / O~O \ I O \ I
COOH
(C7):
OH
~N \ / /
/ o~O \ I O \
COOMe (C8):
OH
g I \ / I / I
/ O~O \ O \
COOH
(C9):

N- OH
-N
\ / /
/ ono \ I o \
COOH
(C10):
~N OH
s I \ / I /
/ o'~o ~ o COOH
(C11):
O OH
N~ I
I \ / I / I
/ O~O \ O
COONa (C12):
off O I \ /
/ O~O \ O \
COOH
(C13):

OH
O ~
\ / /
O~\/~O \
COOH
(C14):
O OH
\ / /
O~O \ ~ O \
COONa (C15):
OH
N \ / /
CI / O~O \ O \
COOH
(C16) OH
O~O \ ~ O
COOH

(C17):
N-N OH
N
I~ ~I ~I
O~O \ O
COOH
(C18) N=N OH
S , i i ~ ono w I o w COOH
(C19) S-N OH
N~ ~
o'~o ~ o COOH
15 (C20) ~N-N OH
s I ~ ~ I
oho \ O
COOH
(C21) Ni I off I~ ~I ~I
o'~o ~ o COOH
(C22):
~N OH
I
p I ~ ~ I ~ I
O~O \ O
COOH
(C23):
OH
S
I / O~O w I O w I
COOH
and all acid, salt, solvate and prodrug derivatives thereof.
III S. Highly Preferred LTB4 Antagonists are as follows:

OH
/ I /
o'~o ~ o COOH
O OH
I / O~O ~ I O
COONa OH
s, I ~ / I / I
/ O~O \ O
COOH
N- OH
-N ~
/ /
/ OHO ~ I o ~
COOH

OH
0, I ~ / I / I
/ O'~O ~ O
COOH
OH
O ~
/ /
/ O~o ~ I o ~
COOH
and all acid, salt, solvate and prodrug derivatives thereof.
IV. Method of Making the LTBg Antagonist Compounds of the Composition and Method of the Invention General reaction schemes (not represented to be specific Examples) applicable for synthesis of the LTB4 antagonist compounds represented by formula (I) are set out below. Numerous literature references and Chemical Abstract registry numbers (e.g., RN 152609-60-4) are supplied as additional aids for preparing reagents used in practicing the synthesis schemes of the invention.

COMPOUNDS USED IN THE COMPOSITIONS AND METHOD
OF THE INVENTION
The following scheme illustrates a process for making Example (1), a 4-substituted oxazole LTBg receptor antagonist:

Scheme 1 O OH
benzyl bromide, Cs2C03, DMF
O~CI
(26) known compound: RN# 156005-61-7 R. W. Harper et al., J. Med. Chem. 1994, 37(15), 2411 I
HO ~ O ~ (30) COOMe i O~CI
known compound: RN 152609-76-2 J. S. Sawyer et al., J. Med. Chem. 1995, 38, 4411 (28) K2C03, Nal, 2-butanone OI' O O ~ O~CF3 i r ~ i ~O
I I ~ o~'cF
-O O -O '~' COOMe TFA, H20, CH3CN
(32) HO ~ ~ / / 1) Tf20, 2,6-lutidine O~O \ I O \ I 2) formamide COOMe (34) /= N O
I ~ ~ BF3 Et20, EtSH
O~O \ O
COOMe (36) /= N H
O~
~ ) NaOH
O~O \ O \ 2) HCI
COOMe (38) /~ N H
O ~
O~\/~O \ I O \
COOH
Known chloride (26) may be alkylated with benzyl bromide to provide chloride (28). Reaction with known ester (30), catalyzed by a suitable base, provides acetophenone (32).
Oxidation with bis(trifluoroacetoxy)iodobenzene gives alpha-hydroxy ketone (34), that may be cyclized with triflic anhydride and formamide to give the 4-substituted oxazole (36). Debenzylation with boron trifluoride etherate and ethanethiol gives oxazole (38), that is hydrolyzed and protonated to provide Example (1).
Scheme 2 The following scheme illustrates a process for making Example (2), a 5(4)-substituted imidazole LTB4 receptor antagonist:

Scheme 2 p I
/ / 1) LiHMDS, TMSCI, THF
I / O~O \ I O~ 2) NCS
COOMe 3) TBAF
(32) O O ~ NI'H
CI ~ I / / / H2N~SBn I / p~0 \ I O \ I K2C03, Nal, DMF
COOMe (40) S H
N~N~ O
/ / BF Et O, EtSH

I / O~O ~ I o ~ I
COOMe (42) S .H
N~N OH
I I I 1) LiOH, MeOH
/ O~O \ O~ 2) Raney Ni, EtOH, NaOH
COOMe 3) HCI
(44) H
~N~ OH
N ~
/ /
HCI I / O
COOH
(2) The trimethylsilyl enol ether of acetophenone (32) is formed and treated with N-chlorosuccinimide followed by tetra-n-butylammonium fluoride to provide the chloroketone (40).
Treatment of (40) with 2-benzyl-2-thiopseudourea and base provides imidazole (42), that is treated with boron trifluoride etherate and ethanethiol to give imidazole (44).
Hydrolysis and protonation provide Example (2) as the hydrochloride salt.
Scheme 3 The following scheme illustrates a process for making Example (3), a 4-substituted thiazole LTB4 receptor antagonist:

_57_ Scheme 3 CI ~ / , , thioformamide, MgC03 O~O \ I O \ I dioxane COOMe (40) != N O
S i I ~ I / / I / I BF3 Et20, EtSH
O~O \ O
COOMe (46) /=N OH
S ~
1 ) LiOH, MeOH
O~O ~ I O ~ I 2) HCI
COOMe (48) /~ N OH
S ~
o'~o ~ o COOH
(3) Chloroketone (40) is treated with thioformamide and magnesium carbonate to give thiazole (46), that is debenzylated with boron trifluoride etherate and ethanethiol giving thiazole (48). Hydrolysis and protonation provides Example (3).
Scheme 4 The following scheme illustrates a process for making Example (4), a 5(3)-substituted pyrazole LTBg receptor antagonist:

Scheme 4 OMe O O \ Me2N-I I ~ I oMe / O~O \ O \ DMF
COOMe (32) 0 o I \
MeZN \ I \ / / I / I 1 ) LiOH, MeOH
/ O~O \ O \ 2) HCI
COOMe 3) NH2NHZ H20, MeOH
(50) N_N.n O I \
I BF3 Et20, EtSH
/ O~O \ O \
COOH
(52) ,H
N'N OH
O~\/~O \ I O \ I
COOH
(4) Treatment of acetophenone (32) with N,N-dimethylformamide dimethyl acetal gives enone (50), that may be hydrolyzed, protonated, and then heated with hydrazine hydrate to provide pyrazole (52). Debenzylation of the resulting pyrazole with boron trifluoride etherate and ethanethiol gives Example (4).
Scheme 5 The following scheme illustrates a process for making Example (5), a 5-substituted isoxazole LTBg receptor antagonist:

Scheme 5 Me2N ~ I ~ / / I / I NH20H, MeOH, H20 / O~O \ O
COOMe (50) N' O O
BF3~EtZ0, EtSH
/
I / O~O ~ I o w I
COOMe (54) N'O OH
/ / 1 ) LiOH, MeOH
I / O~O ~ I O ~ I 2) HCI
COOMe (56) N'O OH
I / O~O ~ I o ~ I
COOH
(5) Treatment of enone (50) with hydroxylamine provides isoxazole (54), that is debenzylated with boron trifluoride etherate and ethanethiol to give isoxazole (56). Hydrolysis and protonation provides Example (5).
Scheme 6 The following scheme illustrates a process for making Example (6), a 5(4)-substituted 1,2,3-triazole LTB4 receptor antagonist:

Scheme 6 I ~ ~ I I
Br ~ i ~ ~ KzC03, KI, DMSO
HO O
I ~ O~CI + COOMe 2-butanone (58) (30) known compounds: RN 152609-60-4 152609-76-2 J. S. Sawyer et al. J. Med. Chem. 1995, 38, 4411 ° I ~
Br ~~ / / - SnBu3 O~O \ I O \ I Pd(PPh3)4, DMF
COOMe (60) o I
i TMSN3, toluene I ~ O~O ~ I o ~ I
COOMe (62) N NH O
N ~ I ~ ( ~ / I / I BF3 Et20, EtSH
O~O ~ O
COOMe (64) ,H
N'N OH
N ~
1) LiOH, MeOH
I , pip ~ I O ~ I 2) HCI
COOMe (66) _H
N'N OH
N ~
I I I
COOH

Known phenol (30) is alkylated with known chloride (58) to give aryl bromide (60). Treatment of (60) with tri-n-butylethynyltin and a palladium catalyst gives alkyne (62).
Heating (62) with trimethylsilyl azide provides triazole (64), that is debenzylated with boron trifluoride etherate and ethanethiol to give triazole (66). Hydrolysis and protonation provides Example (6).
Scheme 7 The following scheme illustrates a process for making Example (7), a 1-substituted pyrrole LTB4 receptor antagonist:

Scheme 7 OH _ O
1) (KS03)2N0, K2P04, H20 ~N ~ I /
I / OH 2) 3-pyrroline, CH3CN I / OH
3) BnBr, KZC03, DMF
(68) (70) o ~N ~ I / 1 ) Nal, 2-butanone 1-bromo-3-chloropropane I
KzC03, DMF / O~CI 2) K2C03, DMF
(72) / I /
HO \ O \
COOMe (30) O
~N ~ I / / / BF3 Et20, EtSH
I / O~O w I O w I
COOMe (74) OH
~N w / /
I / O~O w I O w I
COOMe References for formation of 1-aryl substituted pyrroles: M. Mure and J. P.
Klinman, J. Am. Chem. Soc. 1995, 117(34), 8698;
Y. Lee et al. J. Am. Chem. Soc. 1996, 118(30), 7241 4-Ethylbenzene-1,3-diol (68) is treated with potassium nitrosodisulfonate followed by 3-pyrroline and benzylbromide and a base to provide pyrrole (70). Alkylation with 1-bromo-3-chloropropane gives chloride (72), that is used to alkylate phenol (30) to give pyrrole (74). Debenzylation with boron trifluoride etherate and ethanethiol provides Example (7).
Scheme 8 The following scheme illustrates a process for making Example (8), a 5-substituted 1,2,4-thiadiazole LTB4 receptor antagonist:

Scheme 8 H
O I ~ O,B~O
Br ~~ ~ /
/ O~O / O \ PdCl2(dppf) COOMe (60) Br N~N
O O
.B ~~ ~ / S
O CI
~ O~O I, / 0 COOMe PdCl2(dppf), CszC03, toluene (76) Br ~N O
N I \ ~ / \ / 1) BF3~Et20, EtSH
S
/ O~O I / 0 ~ I 2) aq. NaOH
COOMe 3) aq. NCI
(78) Br ~N OH
N
,S ~ ~ ~ ~ /
/ O~O / O \
COOH

The palladium-catalyzed addition of 4,4,5,5-tetramethyl-[1,3,2]dioxaborolane to bromide (60) gives boronic ester (76). The palladium-catalyzed addition of 3-bromo-5-chloro-1,2,4-thiadiazole to (76) gives ester (78). Debenzylation with boron trifluoride etherate and ethanethiol, followed by hydrolysis and protonation, gives Example (8).
Scheme 9 The following scheme illustrates a process for making Example (9), a 2-substituted thiophene LTB4 receptor antagonist:

Scheme 9 0 0 ~ 1) s ~
,B I , Br O I \ I I PdCl2(dppf), Cs2C03, toluene O~O ~ O
COOMe 2) BF3 Et20, EtSH
(76) off s I ~
O~O ~ O ~ 1 ) aq. LiOH
COOMe 2) NaOH
(80) off s I ~
~ o'n'o ~ o COONa The palladium-catalyzed addition of boronic ester (76) to 2-bromothiophene, followed by debenzylation with boron trifluoride etherate and ethanethiol, provides thiophene (80). Hydrolysis and salt formation provides Example (9).

Scheme 10 The following scheme illustrates a process for making Example (10), a 4-substituted pyrazole LTB4 receptor antagonist:

Scheme 10 I
N-N
I\
I Known compound: RN 39806-90-1 O~O O
COOMe PdCl2(dppf), Cs2C03, toluene (76) N, O w -N i / I / I ~ ) BFa Et20, EtSH
O~O \ O \ 2) aq. NaOH
COOMe 3) aq. HCI
(82) N- OH
-N ~
I~ ~I ~I
O~O \ O
COOH
(10) The palladium-catalyzed addition of boronic ester (76) to 1-methyl-4-iodopyrazole provides pyrazole (82). Debenzylation with boron trifluoride etherate and ethanethiol, followed by hydrolysis and protonation, provides Example (10).
Scheme 11 The following scheme illustrates a process for making Example (11), a 2-substituted thiazole LTBg receptor antagonist:

Scheme 11 O B O~ ~ ~ S /N
I ~ ~ I ~ ~ I ~Br ~O O ~O
COOMe PdCl2(dppf), CszC03, toluene (76) S I \ I I BFs~Et20, EtSH
O~O ~ O
COOMe (84) ~N OH
S I \ I I 1 ) aq. LiOH
O~O ~ O \ 2) HCI
COOMe (86) ~N OH
i S I w ~ o~p I ~ p ~ I
COOH
(11 ) The palladium-catalyzed addition of boronic ester (76) to 2-bromothizaole provides thiazole (84). Debenzylation with boron trifluoride etherate and ethanethiol gives thiazole (86). Hydrolysis and protonation provides Example (11).
Scheme 12 The following scheme illustrates a process for making Example (12), a 4-substituted isoxazole LTB4 receptor antagonist:

_75_ Scheme 12 i I
\ 1) N
O O~ p O'B \ / \ /
PdCl2(dppf), Cs2C03, toluene / O ~\/~ O I / O \
COOMe (76) N, O \
O i I / 1) Me3Sil \ \ /
/ O~O I / O \ I 2) aq. HCI
COOMe 3) NaOH
(88) N- OH
O ~
\ \ /
O~O ~ / O
COONa (12) The palladium-catalyzed addition of boronic ester (76) to 3,5-dimethyl-4-iodoisoxazole provides oxazole (88).
Debenzylation with trimethylsilyl iodide, followed by hydrolysis and salt formation, provides Example (12).
Scheme 13 The following scheme illustrates a process for making Example (13), a 2-substituted furan LTB4 receptor antagonist:

_77_ Scheme 13 o ~
B ~ ~ ~ BBr , CH CI

~ O~O W I O w COOMe (60) OH
TBSCI, imidazole O~O \ O
COOMe (90) oTBs Br ~ / / B(OH)Z
~ O~O ~ I O ~ I Pd(PPh3)4, aq. Na2C03, THF
COOMe (92) OH
O I ~ ~ I ~ I 1) aq. LiOH
O~O \ O~ 2 HCI
COOMe 3) NaOH
(94) off i~ il o'~o ~ o~
COONa (13) _78_ Debenzylation of bromide (60) with boron tribromide provides phenol (90), that is treated with tert-butyldimethylsilyl chloride and imidazole to give silyl ether (92). The palladium-catalyzed addition of (92) to furan-2-boronic acid provides furan (94). Hydrolysis and salt formation gives Example (13).
Scheme 14 The following scheme illustrates a process for making Example (14), a 3-substituted furan LTB4 receptor antagonist:

Scheme 14 TBS
Br ~ / / ~B(OH)z O~O \ I O \ I Pd(PPh3)a, aq. NazC03, THF
COOMe (92) OH
O ~
/ /
1) aq. LiOH
O~O O
COOMe 2) HCI
3) NaOH
(96) OH
O ~
/ o'~o ~ o COONa (14) The palladium-catalyzed addition of (92) to furan-3-boronic acid provides furan (96). Hydrolysis and salt formation gives Example (14).

Scheme 15 The following scheme illustrates a process for making Example (15), a 3-substituted tetrahydrofuran LTB4 receptor antagonist:

Scheme 15 O I ~ / / B(OH)z Br I ~ ~ , I ~ I o O~O \ O \ Pd(PPh3)4, aq. Na2C03, THF
COOMe (60) o o, H2, Pd(C) ~ ono w I o w I
COOMe (98) OH
O
I / I / I 1 ) aq. LiOH
O~O \ O \ 2) HCI
COOMe 3) NaOH
( 100) OH
O
I ~~ ~I
O~O \ O
COONa (15) The palladium-catalyzed addition of bromide (60) to furan-3-boronic acid provides furan (98). Hydrogenation over a palladium catalyst gives tetrahydrofuran (100). Hydrolysis and salt formation gives Example (15).
Scheme 16 The following scheme illustrates a process for making Example (16), a 2-substituted pyrrolidine LTB4 receptor antagonist:

Scheme 16 N
O I w ~O-~ B(OH)2 Br ~ i / / O
I ~ O~O ~ I O ~ I Pd(PPh3)4, aq. Na2C03, THF
COOMe (60) p I
H2, Pd(C) ~' I
' O O ~ O~O \ O \
COOMe ( 102) OH
aq. LiOH
N I ~ ~ I ~ I
~O~O ~ O~O ~ O \
COOMe ( 104) OH
N I I I HCI
~O~O ~ O~O \ O
COOLi ( 106) OH
N
I ~ pip ~ I p ~ I
HCI
COOH
(16) The palladium-catalyzed addition of bromide (60) to N-boc pyrrole-2-boronic acid provides pyrrole (102). Hydrogenation over a palladium catalyst gives pyrrolidine (104).
Hydrolysis and salt formation gives pyrrolidine (106).
Treatment with hydrochloric acid provides Example (16) as the hydrochloride salt.
Scheme 17 The following scheme illustrates a process for making Example (17), a 3-substituted thiophene LTB4 receptor antagonist:

Scheme 17 o w o ~
Br ~ I ~ ~ B(oH)2 I ~ O~CI Pd(PPh3)4, aq. NaZC03, THF I ~ O~CI
(5g) (108) I I
HO ~ ~ \ (110) CN
known compound: RN# 152609-78-4 S ~ O
J. S. Sawyer et al., J. Med. Chem. 1995, 38, 4411 i ~
KZC03, KI, DMSO, 2-butanone I ~ O~O \ I O
CN
(112) OH
S ~
BBr3, CH2C12 I \ I I 1) NaOH
O~O ~ O \ 2) HCI
CN
(114) OH
S ~
I I I
o'~o ~ o COOH
(y 7) The palladium-catalyzed addition of bromide (58) to thiophene-3-boronic acid provides thiophene (108).
Alkylation of known phenol (110) with (108) catalyzed by base provides thiophene (112). Debenzylation with boron tribromide gives thiophene (114). Hydrolysis and protonation provide Example (17).
Scheme 18 The following scheme illustrates a process for making Example (18), a 5-substituted 1,2,3,4-thiatriazole LTB4 receptor antagonist:

_87_ Scheme 18 /
\ ~ \ ~ t-bromo-3-chloropropane ~ / ~ 1) KZCO3, Nal, 2-butanone HO O CIO \ O
COOMe KZC03, DMF COOMe O OH
H I \
(30) (116) / OH
known compound:
RN 37470-83-0 (118) 2) Cs2C03, BnBr, DMF
O O I \ 1) HS~SH
H \ / /
TsOH
O~O \ I O I 2) NaH, DMF, HMPA
COOMe 3) piperidine ( 120) S O I \ 1) \ / / / -+N CI
NHZS I / O~\/~O \ I O \ I I Me COOMe 2) NaN3 (122) NN-N O
S I I I 1) BF3EtZ0, CHZCIZ
/ O~O \ O~ 2) aq. NaOH
COOMe 3) aq. NCI
(124) N~N OH
N I
S I
/ O~O / O
COOH
(18) Reference for formation of dithioacids: N. C. Gonnella et al. Syn. Commun.
1979, 17 Reference for formation of 5-substituted 1,2,3,4-thiatriazoles from dithioacids:
S. I. Ikeda et al., Synthesis 1990, 415 Phenol (30) is alkylated with 1-bromo-3-chloropropane to give chloride (116), that is in turn to be treated with known aldehyde (118) and a base, followed by benzylation with benzyl bromide and a base, to provide aldehyde (120).
From aldehyde (120) is made the thioacetal by treatment with 1,2-ethanedithiol. The resulting thioacetal is then to be treated with base to provide the thioacid. Treatment with piperidine makes piperidinium salt (122). By the teaching of Ikeda, infra, (the disclosure of which is incorporated herein by reference) treatment of (122) with 2-chloropyridinium methyl iodide followed by azide ion will give the 1,2,3,4-thiatriazole (124). Debenzylation with boron trifluoride etherate and ethanethiol, followed by hydrolysis and protonation, will provide the product of Example (18).
Scheme 19 The following scheme illustrates a process for making Example (19), a 4-substituted 1,2,3-thiadiazole LTB4 receptor antagonist:

_89_ Scheme 19 0 0 ~ ~
NHzNHCOOEt O~O I ~ O
COOMe (32) EtO~N.N O

O~O ~ / O ~
COOMe ( 128) N;N O
~ / I 1) BF3Et20, EtSH
O~O ~ O ~ 2) aq. NaOH
COOMe 3) aq. NCI
( 130) N=N OH
S ~
O~O ~ O \
COOH
(19) Reference for 1,2,3-thiadiazole formation: E. W. Thomas et al., J. Med. Chem.
1985, 28, 442.

Treatment of acetophenone (32) with ethyl carbazate will give the hydrazone (128). Use of thionyl chloride by the method of Thomas et. al. (infra., the disclosure of which is incorporated herein by reference) will give an intermediate 1,2,3-thiadiazole (130), that is to be debenzylated with boron trifluoride etherate and ethanethiol, then hydrolyzed and protonated to give the product of Example (19).
Scheme 20 The following scheme illustrates a process for making Example (20), a 3-substituted 1,2,5-thiadiazole LTB4 receptor antagonist:

Scheme 20 c1 .s,.
\ N N
\ / / / CI~S.N:S~CI
/ O~O \ I O \ I (trithiazyl trichloride) COOMe (62) S'N O
N ~ I I \ I / / I / I 1 ) BF3 EtzO, EtSH
/ O~O \ O \ 2) aq. NaOH
COOMe 3) aq. HCI
( 132) S'N OH
N~ I
/ O'~O / O \
COOH
(20) Reference for 1,2,5-thiadiazole formation: E. W. Thomas et al., J. Med. Chem.
1985, 28, 442.
Alkyne (62) is to be treated with trithiazyl trichloride by the method of Thomas et. al. (infra., the disclosure of which is incorporated herein by reference) to provide thiadiazole (132). Debenzylation with boron trifluoride etherate and ethanethiol, followed by hydrolysis and protonation, will provide the product of Example (20).

Scheme 21 The following scheme illustrates a process for making Example (21), a 2-substituted 1,3,4-thiadiazole LTB4 receptor antagonist:
Scheme 21 CN.N
S
O O \ Br ,B ~~/ known compound: RN 61929-24-6 O ~ \ I \ / I PCT W O 9730981 / O~O / O \ PdCl2(dppf), Cs2C03, toluene COOMe (76) //N'N O I \
\S ~ \ / I \ / I 1) BF3Et20, EtSH
/ O~O / O \ 2) aq. NaOH
COOMe 3) aq. HCI
(134) //N'N OH
\
/ O~O ~ O \
COOH
(21 ) The palladium-catalyzed addition of boronic ester (76) to 2-bromo-1,3,4-thiadiazole will provide ester (134).
Debenzylation with boron trifluoride etherate and ethanethiol, followed by hydrolysis and protonation, will provide the product of Example (21).

Scheme 22 The following scheme illustrates a process for making Example (22), a 5-substituted isothiazole LTB4 receptor antagonist:
Scheme 22 N ~~
S
O~ ~ B(OH)z gr ~ ~' //\ known compound: RN 216971-00-5 O~CI
Pd(PPh3)4, NazC03, EtOH, H20 (58) HO \ O \
O
N ~ I , COOMe (30) .S
O~CI
K2C03, KI, DMSO, (136) N/ I
'S I \ I I 1 ) BF3 EtzO, EtSH
O~O ~ O ~ 2) aq. NaOH
COOMe 3) aq. NCI
(138) N~ I OH
I~ I I
o'~O
COOH
(22) The palladium-catalyzed addition of bromide (58) to 3-methylisothiazole-5-boronic acid will provide isothiazole (136). Alkylation of phenol (30) with (136) catalyzed by base will provide isothiazole (138). Debenzylation with boron trifluoride etherate and ethanethiol, followed by hydrolysis and protonation, will provide the product of Example (22).
Scheme 23 The following scheme illustrates a process for making Example (23), a 2-substituted oxazole LTB4 receptor antagonist:

Scheme 23 ~N
O
Br O O \ known compound: RN 125533-82-6 ,B I~/ R. D. Miller et al., Chem. Mater. 1994, O I \ I \ / I 6(7), 1023.
O~O ~ O \ PdCl2(dppf), Cs2C03, toluene COOMe (76) N o I ~
O I \ I I 1) BF3~Et20, EtSH
O~O ~ O \ 2) aq. NaOH
COOMe 3) aq. HCI
( 140) ~N OH
o I ~ I ~ ~ I
O~O ~ O
COOH
(23) The palladium-catalyzed addition of boronic ester (76) to 2-bromooxazole will provide oxazole (140). Debenzylation with boron trifluoride etherate and ethanethiol, followed by hydrolysis and protonation, will provide the product of Example (23).

Scheme 24 The following scheme illustrates a process for making Example (24), a 3-substituted thiophane LTB4 receptor antagonist:

Scheme 24 OH
S
I I ~ Et3SiH, TFA, benzene O~O ~ O
CN
(114) OH
S
1 ) aq. NaOH
2) HCI
CN
( 142) OH
S
I I
o'~o ~ o COOH
(24) Reference for formation of tetrahydrothiophenes: D. N. Kursanov et al.
Tetrahedron 1975, 31, 311 Thiophene (114) may be reduced in the presence of triethylsilane and trifluoroacetic acid by the method of Kursanov et. al. (infra., the disclosure of which is incorporated herein by reference) to provide the thiophane (142). Hydrolysis and protonation will provide the product of Example (24).

V. PREPARATIVE EXAMPLES 1 TO 17:
Example 1 Preparation of 2-(3-[3-(2-Ethyl-5-hydroxy-4-oxazol-4-yl-phenoxy)propoxy]-2-propyl-phenoxy?benzoic acid.
o H o i o~ci I ~ o~ci known compound: RN# 156005-61-7 R. W. Harper et al., J. Med. Chem. 1994, 37(15), 2411-20 A. Preparation of 1-[2-benzyloxy-4-(3-chloropropoxy)-5-ethylphenyl]ethanone.
A mixture of 1-[2-hydroxy-4-(3-chloropropoxy)-5-ethylphenyl]ethanone (26.1 g, 102 mmol), cesium carbonate (33.4 g, 103 mmol), and benzyl bromide (12.2 ml, 103 mmol), in N,N-dimethylformamide (300 mL) was stirred for 5 h at room temperature. The mixture was diluted with ethyl acetate and washed four times with water. The organic layer was dried (sodium sulfate), filtered, and concentrated in vacuo. The resulting oil was triturated with ethyl acetate and hexane, allowed to stand for 18 h, then cooled at 0 °C
for 3 h. The resulting precipitate was collected via vacuum filtration to provide 24.3 g (690) of the title compound as white crystals: mp 60-61 °C. 1H NMR (CDC13) 8 7.68 (s, 1H), 7.40 (m, 5H), 6.48 (s, 1H), 5.17 (s, 2H), 4.13 (t, J =

6 Hz, 2H), 3.75 (t, J = 6 Hz, 2H), 2.56 (s, 3H), 2.55 (q, J = 7 Hz, 2H), 2.26 (quintet, J = 6 Hz, 2H), 1.16 (t, J
- 7 Hz, 3H); TOF MS ES exact mass calculated for C20H24C103 (p+1): m/z = 347.1414. Found: 347.1402; IR
(CHC13, cm ) 1659, 1602, 1266.
Anal. Calcd for C20H23C103: C, 69.26; H, 6.68. Found: C, 69.30; H, 6.52.
O O ~ / /
--I- Ho 0 / O~CI COOMe known compound: RN# 152609-76-2 J. S. Sawyer et al., J. Med. Chem. 1995, 38, 4411 O O
/ /
O~O ~ ~ O
COOMe B. Preparation of 2-~3-[3-(4-acetyl-5-benzyloxy-2-ethylphenoxy)propoxy]-2-propyl-phenoxy)benzoic acid methyl ester.
A mixture of 1-[2-benzyloxy-4-(3-chloropropoxy)-5-ethylphenyl]ethanone (7.27 g, 21.0 mmol) and sodium iodide (3.14 g, 23.1 mmol) in 2-butanone (100 mL) was heated at reflux for 18 h. The mixture was cooled to room temperature, filtered, and concentrated in vacuo. The residue was dissolved in N,N-dimethylformamide (100 mL) and treated with 2-(3-hydroxy-2-propylphenoxy)benzoic acid methyl ester (6.0 g, 21 mmol) and potassium carbonate (3.2 g, 23 mmol) at room temperature for 15 h. The mixture was diluted with ethyl acetate and washed four times with water and once with saturated sodium chloride solution. The organic layer was dried (sodium sulfate), filtered, and concentrated in vacuo. Chromatography (silica gel, 100 ethyl acetate/90o hexane) of the residue provided 9.2 g (720) of the title compound as a colorless oil. H NMR
(CDC13) 8 7.88 (d, J = 9 Hz, 1H), 7.69 (s, 1H), 7.38 (m, 6H), 7.12 (d, J = 8 Hz, 1H), 7.07 (d, J = 8 Hz, 1H), 6.80 (d, J = 8 Hz, 1H) , 6.67 (d, J = 8 Hz, 1H) , 6.50 (s, 1H) , 6.44 (d, J = 9 Hz, 1H), 5.14 (s, 2H), 4.20 (m, 4H), 3.83 (s, 3H), 2.65 (t, J = 7 Hz, 2H), 2.57 (q, J = 7 Hz, 2H), 2.56 (s, 3H), 2.32 (quintet, J = 6 Hz, 2H), 1.55 (hextet, J = 7 Hz, 2H), 1.15 (t, J = 8 Hz, 3H), 0.90 (t, J = 7 Hz, 3H); IR

(CHC13, cm ) 2965, 1726, 1602, 1461.
Anal. Calcd for C37H4007: C, 74.48; H, 6.76. Found: C, 74.39; H, 6.77.

O
O~O ~ ~ O ~
COOMe O
HO ~~
O~O ~ ~ O
COO Me C. Preparation of 2-(3-~3-[5-benzyloxy-2-ethyl-4-(2-hydroxyacetyl)phenoxy]propoxy -2-propylphenoxy)benzoic acid methyl ester.
A mixture of 2-~3-[3-(4-acetyl-5-benzyloxy-2-ethylphenoxy)propoxy]-2-propyl-phenoxy}benzoic acid methyl ester (5.31 g, 8.89 mmol) and water (10 mL) in acetonitrile (50 mL) was treated with trifluoroacetic acid (1.4 mL), 18 mmol) and [bis(trifluoroacetoxy)iodo]benzene (7.65 g, 17.8 mmol). The resulting mixture was heated at reflux for 4 h then concentrated in vacuo. The residue was dissolved in methylene chloride and washed once with water. The aqueous layer was extracted twice with fresh portions of methylene chloride. The combined organic layers were washed three times with saturated sodium bicarbonate solution, once with saturated sodium chloride solution, dried (sodium sulfate), filtered, and concentrated in vacuo. Chromatography (silica gel, 20~ ethyl acetate/80o hexane) of the residue provided 1.68 g (31°s) of the title compound as a brown oil. H NMR
(CDC13) 8 7.92 (s, 1H), 7.88 (d, J = 9 Hz, 1H), 7.40 (m, 6H), 7.12 (d, J = 9 Hz, 1H), 7.05 (d, J = 9 Hz, 1H), 6.79 (d, J = 8 Hz, 1H), 6.66 (d, J = 8 Hz, 1H), 6.50 (s, 1H), 6.43 (d, J = 8 Hz, 1H), 5.15 (s, 2H), 4.65 (s, 2H), 4.22 (m, 4H), 3.83 (s, 3H), 2.65 (m, 4H), 2.34 (quintet, J = 6 Hz, 2H), 1.55 (hextet, J = 7 Hz, 2H), 1.17 (t, J = 8 Hz, 3H), 0.89 (t, J = 8 Hz, 3H); TOS MS ES exact mass calculated for C37H4108 (p+1): m/z = 613.2801. Found: 613.2833.
° I~
HO ~~
I / O~O ~ ( O ~ I
COOMe /= N
o, I, ~ ono ~ I o ~
COOMe D. Preparation of 2-~3-[3-(5-benzyloxy-2-ethyl-4-oxazol-4-yl-phenoxy)propoxy]-2-propylphenoxy)benzoic acid methyl ester.
To a solution of 2-(3-{3-[5-benzyloxy-2-ethyl-4-(2-hydroxyacetyl)phenoxy]propoxy}-2-propylphenoxy)benzoic acid methyl ester (1.39 g, 2.27 mmol) in methylene chloride (20 mL) cooled to -78 °C was added triflic anhydride (0.57 mL, 3.4 mmol) and 2,6-lutidine (0.40 mL, 3.4 mmol). The resulting mixture was stirred for 1 h then poured into ether and water. The organic layer was separated and washed once with saturated sodium chloride solution, dried (sodium sulfate), filtered, and concentrated in vacuo. The residue was dissolved in a 2:1 mixture of formamide/N,N-dimethylformamide (9 mL) and heated at 120 °C in a sealed tube for 4 h. The mixture was cooled to room temperature and diluted with ethyl acetate. The mixture was washed four times with water, once with saturated sodium chloride solution, dried (sodium sulfate), filtered, and concentrated in vacuo. Chromatography (silica gel, 10o ethyl acetate/90~
hexane) of the residue provided 89 mg (60) of the title product as a colorless oil. 1H NMR (CDC13) 8 7.92 (s, 1H), 7.85 (s, 1H), 7.83 (m, 2H), 7.35 (m, 6H), 7.03 (d, J = 8 Hz, 1H), 7.00 (d, J = 8 Hz, 1H), 6.73 (d, J = 8 Hz, 1H), 6.62 (d, J = 8 Hz, 1H), 6.52 (s, 1H), 6.35 (d, J = 8 Hz, 1H), 5.07 (s, 2H), 4.14 (m, 4H), 3.76 (s, 3H), 2.61 (m, 4H), 2.26 (quintet, J = 6 Hz, 2H), 1.48 (hextet, J = 7 Hz, 2H), 1.15 (t, J = 8 Hz, 3H), 0.84 (t, J = 8 Hz, 3H).
/= N
o, I/ / /
/ ono ~ I o ~
COOMe ~N OH
O ~
I / O~O ~ I O ~ I
COOMe E. Preparation of 2-(3-[3-(2-ethyl-5-hydroxy-4-oxazol-4-yl-phenoxy)propoxy]-2-propylphenoxy]benzoic acid methyl ester.

To a solution of 2-{3-[3-(5-benzyloxy-2-ethyl-4-oxazol-4-yl-phenoxy)propoxyJ-2-propylphenoxy}benzoic acid methyl ester (89 mg, 0.14 mmol) in ethanethiol (2 mL) was treated with boron trifluoride etherate (0.27 mL, 2.2 mmol) at room temperature for 4 h. The solution was poured into ether and washed once with water, once with saturated sodium bicarbonate solution, once with saturated sodium chloride solution, dried (sodium sulfate), filtered, and concentrated in vacuo. Chromatography (silica gel, 15~ ethyl acetate/85~
hexane) of the residue provided 34 mg (450) of the title product as a light brown oil. 1H NMR (CDC13) 8 7.99 (d, J =
1 Hz, 1H), 7.90 (d, J = 1 Hz, 1H), 7.88 (dd, J = 8, 2 Hz, 1H), 7.38 (t, J = 7 Hz, 1H), 7.15 (s, 1H), 7.10 (d, J = 9 Hz, 1H), 7.06 (d, J = 9 Hz, 1H), 6.81 (d, J = 9 Hz, 1H), 6.70 (d, J = 9 Hz, 1H), 6.52 (s, 1H), 6.44 (d, J = 9 Hz, 1H), 4.20 (m, 4H), 3.83 (s, 3H), 2.65 (t, J = 8 Hz, 2H), 2.58 (q, J = 8 Hz, 2H),~2.33 (quintet, J = 6 Hz, 2H), 1.55 (hextet, J = 7 Hz, 2H), 1.17 (t, J = 8 Hz, 3H), 0.91 (t, J =
8 Hz, 3H); MS ES+ m/e = 532 (p + 1).
/=N OH
/
/ O~O \ O
COOMe /= N H
O ~
/ /
/ O~O ~ ~ O ~
COOH

F. Preparation of 2-~3-[3-(2-ethyl-5-hydroxy-4-oxazol-4-yl-phenoxy)propoxy]-2-propylphenoxy]benzoic acid.
To a solution of 2-{3-[3-(2-ethyl-5-hydroxy-4-oxazol-4-yl-phenoxy)propoxy]-2-propylphenoxy}benzoic acid methyl ester (89 mg, 0.14 mmol) in methanol (2 mL) was added 1 M lithium hydroxide solution (0.28 mL) and the resulting mixture warmed at 60 °C for 3.5 h. The mixture was cooled to room temperature and concentrated in vacuo. The aqueous residue was diluted with water and the pH adjusted to ~4. The mixture was extracted three times with methylene chloride.
The combined organic extracts were dried (sodium sulfate), filtered, and concentrated in vacuo to provide 27 mg (920) of the title compound as a yellow solid. H NMR (DMSO-d6) 8 12.83 (bs, 1H) , 10.12 (bs, 1H) , 8.39 (s, 1H) , 8.25 (s, 1H), 7.78 (dd, J = 8, 1 Hz, 1H), 7.64 (s, 1H), 7.47 (t, J =
8 Hz, 1H), 7.16 (m, 2H), 6.80 (t, J = 8 Hz, 2H), 6.56 (s, 1H), 6.35 (d, J = 8 Hz, 1H), 4.20 (t, J = 6 Hz, 2H), 4.12 (t, J = 6 Hz, 2H); 2.54 (m, 4H), 2.24 (quintet, J = 6 Hz, 2H), 1.43 (hextet, J = 8 Hz, 2H), 1.10 (t, J = 8 Hz, 3H), 0.80 (t, J = 8 Hz, 3H); TOF MS ES exact mass calculated for C3~H32N07 (p+1): m/z = 518.2179. Found: 518.2206; IR

(KBr, cm ) 2961, 1696, 1460, 1222.
Anal. Calcd for C3~H31N07: C, 69.62; H, 6.04; N, 2.71.
Found: C, 68.71; H, 5.82; N, 2.65.

Example 2 Preparation of 2-(3-~3-[2-Ethyl-5-hydroxy-4-(3H-imidazol-4-yl)phenoxy]propoxy?-2-propyl-phenoxy)benzoic acid hydrochloride.
° I~
W
I / O~O ~ I O ~ I
COOMe O
Ii i i ~ ,ono ~ I o COOMe A. Preparation of 2-(3-~3-[5-benzyloxy-4-(2-chloroacetyl)-2-ethylphenoxy]propoxy}-2-propylphenoxy)benzoic acid methyl ester.
To a solution of 2-{3-[3-(4-acetyl-5-benzyloxy-2-ethylphenoxy)propoxy]-2-propyl-phenoxy}benzoic acid methyl ester (3.04 g, 5.09 mmol) in tetrahydrofuran (50 mL) cooled to -78 °C was added a solution of 1 M lithium hexamethyldisilazide in tetrahydrofuran (11.2 mL, 11.2 mmol) portion wise. After stirring for 20 min, trimethylsilyl chloride (2.6 mL, 20 mmol) was added and the mixture warmed to 0 °C and stirred for 30 min. The mixture was evaporated in vacuo and the residue dissolved in hexane. The resulting solution was filtered and concentrated in vacuo. The residue was dissolved in tetrahydrofuran (50 mL), cooled to 0 °C, and treated with N-chlorosuccinimide (750 mg, 5.6 mmol). The mixture was warmed to room temperature and stirred for 30 min, then heated at reflux for 2 h. The mixture was cooled to room temperature and treated with water (4 mL) and a solution of 1 N tetra-n-butylammonium fluoride in tetrahydrofuran (6 mL). After stirring for 15 min the mixture was diluted in ether and washed once with water, once with saturated sodium chloride solution, dried (sodium sulfate), filtered, and concentrated in vacuo.
Chromatography (silica gel, 10~ ethyl acetate/90o hexane) of the residue provided 1.94 g (600) of the title compound as a white solid. 1H NMR (CDC13) 8 7.89 (d, J = 8 Hz, 1H), 7.77 (s, 1H), 7.40 (m, 6H), 7.12 (d, J = 9 Hz, 1H), 7.06 (d, J =
8 Hz, 1H), 6.80 (d, J = 8 Hz, 1H), 6.66 (d, J = 8 Hz, 1H), 6.49 (s, 1H), 6.43 (d, J = 8 Hz, 1H), 5.15 (s, 2H), 4.68 (s, 2H), 4.20 (q, J = 6 Hz, 4H), 3.82 (s, 3H), 2.65 (t, J = 7 Hz, 2H), 2.59 (q, J = 7 Hz, 2H), 2.32 (quintet, J = 6 Hz, 2H), 1.54 (hextet, J = 8 Hz, 2H), 1.16 (t, J = 8 Hz, 3H), 0.89 (t, J = 7 Hz, 3H); TOF MS ES exact mass calculated for C37H4~C107 (p+1): m/z = 631.2463. Found: 631.2470; IR

(CHC13, cm ) 2964, 1720, 1603, 1461.
Anal. Calcd for C37H39C107: C, 70.41; H, 6.23. Found: C, 70.04; H, 5.97.

O
c1 I
I ~ O~O w I o w I
COOMe S H
~N~
N ~
~ ono w I o w COOMe B. Preparation of 2-(3-i3-[5-benzyloxy-4-(2-benzylsulfanyl-3H-imidazol-4-yl)-2-ethyl-phenoxy]propoxy~-2-propylphenoxy)benzoic acid methyl aster.
A mixture of 2-(3-{3-[5-benzyloxy-4-(2-chloroacetyl)-2-ethylphenoxy]propoxy}-2-propylphenoxy)benzoic acid methyl ester (800 mg, 1.27 mmol), 2-benzyl-2-thiopseudourea hydrochloride (313 mg, 1.52 mmol), sodium iodide (77 mg, 0.51 mmol), and potassium carbonate (700 mg, 5.06 mmol) in N,N-dimethylformamide (20 mL) was treated at 80 °C for 6 h.
The mixture was cooled, diluted with diethyl ether, and washed once with water. The organic layer was dried (sodium sulfate), filtered, and concentrated in vacuo.
Chromatography (silica gel, 30o ethyl acetate/70~ hexane) of the residue provided 376 mg (40~) of the title compound as a yellow amorphous solid. H NMR (CDC13) 8 7.89 (d, J = 8 Hz, 1H), 7.36 (m, 9H), 7.20 (m, 5H), 7.21 (d, J = 9 Hz, 1H), 7.06 (d, J = 8 Hz, 1H), 6.79 (d, J = 8 Hz, 1H), 6.67 (d, J =

8 Hz, 1H), 6.55 (s, 1H), 6.43 (d, J = 8 Hz, 1H), 5.07 (s, 2H), 4.21 (t, J = 6 Hz, 2H), 4.18 (t, J = 6 Hz, 2H), 4.10 (s, 2H), 3.83 (s, 3H), 2.63 (m, 4H), 2.31 (quintet, J = 6 Hz, 2H), 1.55 (hextet, J = 7 Hz, 2H), 1.18 (t, J = 8 Hz, 3H), 0.90 (t, J = 7 Hz, 3H); TOF MS ES exact mass calculated for C45H47N206S (p+1): m/z = 743.3155. Found:

743.3142; IR (CHC13, cm ) 2963, 1720, 1602, 1453.
Anal. Calcd for C45H46N206S: C, 72.75; H, 6.24; N, 3.77.
Found: C, 72.69; H, 6.17; N, 3.56.
S H
~N~
N, I~
~ ono ~ I o ~
COOMe S ,H
~N H
N ~
I / O~O w I O
COOMe C. Preparation of 2-(3-~3-[4-(2-benzylsulfanyl-3H-imidazol-4-yl)-2-ethyl-5-hydroxyphenoxy]propoxy}-2-propylphenoxy)benzoic acid methyl ester.
A solution of 2-(3-{3-[5-benzyloxy-4-(2-benzylsulfanyl-3H-imidazol-4-yl)-2-ethyl-phenoxy]propoxy}-2-propylphenoxy)benzoic acid methyl ester (360 mg, 0.49 mmol) in ethanethiol (7 mL) was treated-with boron trifluoride etherate at room temperature for 3.5 h. The mixture was diluted with diethyl ether and water. The organic layer was separated and washed with saturated sodium bicarbonate solution, dried (sodium sulfate), filtered, and concentrated in vacuo. Chromatography (silica gel, 20~ ethyl acetate/80o hexane) of the residue provided 154 mg (480) of the title compound as an orange oil. 1H NMR (CDC13) 8 7.85 (d, J = 8 Hz, 1H), 7.36 (t, J = 7 Hz, 1H), 7.20 (m, 7H), 7.12 (s, 1H), 7.05 (m, 3H), 6.79 (d, J = 8 Hz, 1H), 6.65 (d, J = 8 Hz, 1H), 6.54 (s, 1H), 6.41 (d, J = 8 Hz, 1H), 4.20 (s, 2H), 4.17 (m, 4H), 3.82 (s, 3H), 2.62 (t, J = 8 Hz, 2H), 2.54 (q, J = 7 Hz, 2H), 2.30 (quintet, J = 6 Hz, 2H), 1.53 (hextet, J
- 8 Hz, 2H), 1.14 (t, J = 7 Hz, 3H), 0.89 (t, J = 8 Hz, 3H);
TOF MS ES exact mass calculated for C38H41N206S (p+1):
m/z = 653.2685. Found: 653.2669.
Anal. Calcd for C38H4~N206S: C, 69.92; H, 6.18; N, 4.29.
Found: C, 69.44; H, 6.25; N, 3.99.

S H
~N~ H
N ~
/ /
/ O~O ~ ~ O ~
COOMe ~HCI
,H
~N H
N ~
/ /
O~O ~ ~ O
COOH
D. Preparation of 2-(3-~3-[2-ethyl-5-hydroxy-4-(3H-imidazol-4-yl)phenoxy]propoxy)-2-propyl-phenoxy)benzoic acid hydrochloride.
A solution of 2-(3-{3-[4-(2-benzylsulfanyl-3H-imidazol-4 yl)-2-ethyl-5-hydroxyphenoxy]propoxy}-2-propylphenoxy)benzoic acid methyl ester (154 mg, 0.235 mmol) in methanol (3 mL) was treated with 1 N lithium hydroxide solution at 60 °C for 3.5 h. The mixture was cooled to room temperature and concentrated in vacuo. The solution was diluted with water and adjusted to pH 4. The aqueous solution was extracted three times with methylene chloride.
The combined organic layers were dried (sodium sulfate), filtered, and concentrated in vacuo. The residue was dissolved in ethanol (3 mL) and treated with 0.2 N sodium hydroxide solution (1 mL) and Raney nickel (75 mg) at 75 °C
for 4 h. The mixture was cooled to room temperature, TM
filtered through Celite , and the filtrate concentrated in vacuo. The residue was diluted with water and adjusted to pH 2 with 1 N hydrochloric acid. The resulting precipitate was collected via vacuum filtration to provide 27 mg (21~) of the title compound. TOF MS ES exact mass calculated for C3~H33N206 (p+1): m/z = 517.2339. Found: 517.2340.
Example 3 Preparation of 2-~3-[3-(2-Ethyl-5-hydroxy-4-thiazol-4-yl-phenoxy)propoxy]-2-propyl-phenoxy~benzoic acid.
O O
ono ~ I o COOMe /= N
s, \ I , ~ ono ~ I o COOMe A. Preparation of 2-(3-[3-(5-benzyloxy-2-ethyl-4-thiazol-4-yl-phenoxy)propoxy]-2-propylphenoxy)benzoic acid methyl ester.
A mixture of 2-(3-~3-[5-benzyloxy-4-(2-chloroacetyl)-2-ethylphenoxy]propoxy}-2-propylphenoxy)benzoic acid methyl ester (500 mg, 0.792 mmol), thioformamide (20 mL, 8.0 mmol), and magnesium carbonate in dioxane (10 mL) was heated at reflux for 2 h. The mixture was cooled to room temperature and diluted with diethyl ether and 0.2 M sodium hydroxide solution. The organic layer was separated, washed with saturated sodium chloride solution, dried (sodium sulfate), filtered, and concentrated in vacuo. Chromatography (silica gel, 10~ ethyl acetate/90o hexane) of the residue provided 254 mg (50~) of the title compound as a colorless oil. H
NMR (CDC13) 8 8.91 (s, 1H), 8.11 (s, 1H), 7.87 (dd, J = 8, 1 Hz, 1H), 7.84 (d, J = 1 Hz, 1H), 7.40 (m, 6H), 7.08 (m, 2H), 6.80 (d, J = 8 Hz, 1H), 6.68 (d, J = 8 Hz, 1H), 6.62 (s, 1H), 6.43 (d, J = 8 Hz, 1H), 5.16 (s, 2H), 4.21 (t, J = 6 Hz, 4H), 3.83 (s, 3H), 2.68 (m, 4H), 2.32 (quintet, J = 6 Hz, 2H), 1.56 (hextet, J = 8 Hz, 2H), 1.21 (t, J = 7 Hz, 3H), 0.90 (t, J = 7 Hz, 3H); TOF MS ES exact mass calculated for C38H4~N06S (p+1): m/z = 638.2576. Found:

638.2579. IR (CHC13, cm ) 2964, 1719, 1563, 1461.
/= N
S ~ I / / /
O~O ~ I O ~
COOMe ~N H
S ~
/ /
/ O~O \ I O \
COOMe B. Preparation of 2-(3-L3-(2-ethyl-5-hydroxy-4-thiazol-4-yl-phenoxy)propoxy]-2-propylphenoxy}benzoic acid methyl ester.
A solution of 2-{3-f3-(5-benzyloxy-2-ethyl-4-thiazol-4-yl-phenoxy)propoxy]-2-propyl-phenoxy}benzoic acid methyl ester (243 mg, 0.366 mmol) in ethanethiol (7 mL) was treated with boron trifluoride etherate at room temperature for 4 h. The mixture was diluted with diethyl ether, washed once with water, once with saturated sodium bicarbonate solution, dried (sodium sulfate), filtered, and concentrated in vacuo.
Chromatography (silica gel, 15~ ethyl acetate/85~ hexane) of the residue provided 132 mg (65~) of the title compound as a colorless oil. 1H NMR (CDC13) S 8.88 (d, J = 1 Hz, 1H), 7.88 (dd, J = 8, 1 Hz, 1H), 7.44 (d, J = 1 Hz, 1H), 7.38 (m, 2H), 7.08 (m, 2H), 6.81 (d, J = 8 Hz, 1H), 6.68 (d, J = 8 Hz, 1H) , 6.55 (s, 1H) , 6.43 (d, J = 8 Hz, 1H) , 4.21 (t, J =
6 Hz, 4H), 3.83 (s, 3H), 2.63 (m, 4H), 2.33 (quintet, J = 6 Hz, 2H), 2.56 (hextet, J = 8 Hz, 2H), 1.19 (t, J = 8 Hz, 3H), 0.91 (t, J = 7 Hz, 3H); TOF MS ES exact mass calculated for C31H34NO6S (p+1): m/z = 548.2107. Found:
548.2085.

/=N H
S ~
0~0 ~ ~ O
COOMe /= N H
S ~
O~O ~ I O
COOH
C. Preparation of 2-(3-L3-(2-ethyl-5-hydroxy-4-thiazol-4-yl-phenoxy)propoxy]-2-propylphenoxy}benzoic acid.
A solution of 2-{3-[3-(2-ethyl-5-hydroxy-4-thiazol-4-yl-phenoxy)propoxy]-2-propylphenoxy}benzoic acid methyl ester (130 mg, 0.236 mmol) in methanol (4 mL) was treated with 1 M
lithium hydroxide solution at 60 °C for 3 h. The mixture was cooled to room temperature, concentrated in vacuo, and diluted with water. The solution was adjusted to pH ~4 and extracted three times with methylene chloride. The combined organic layers were dried (sodium sulfate), filtered, and concentrated in vacuo. The residue was dissolved in a minimum of methylene chloride and hexane was added until the solution became cloudy. The mixture was concentrated slowly in vacuo to give 96 mg (76~) of the title compound. H NMR
(CDC13) 8 8.90 (s, 1H), 8.23 (dd, J = 8, 1 Hz, 1H), 7.41 (m, 2H), 7.38 1H), 7.29 (m, 2H), 6.82(d, J = Hz, 1H), (s, 8 6.71 (d, J 8 Hz, 1H) 6. (d, J 8 Hz, 1H) 6.54 (s, = , 62 = , 1H), 4.25 J = 6 Hz, 2H),4.22 (t, J = 6 Hz, 2H), 2.59 (t, (m, 4H), 2.35 (quintet, J = 6 Hz, 2H), 1.50 (hextet, J = 8 Hz, 2H), 1.19 (t, J = 7 Hz, 3H), 0.88 (t, J = 8 Hz, 3H);
TOF MS ES exact mass calculated for C30H32NO6S (p+1): m/z - 534.1950. Found: 534.1957. IR (CHC13, cm ) 2965, 1738, 1454.
Anal. Calcd for C30H31N06S: C, 67.52; H, 5.86; N, 2.62.
Found: C, 67.19; H, 5.72; N, 2.53.
Exan~le ~
Preparation of 2-(3-(3-[2-Ethyl-5-hydroxy-4-(2H-pyrazol-3-yl)phenoxy]propoxy?-2-propyl-phenoxy)benzoic acid.
O
O \ I O \
COOMe O
O~O O
COOMe A. Preparation of 2-(3-(3-[5-benzyloxy-4-(3-dimethylaminoacryloyl)-2-ethyl-phenoxy]propoxy)-2-propylphenoxy)benzoic acid methyl ester.
A mixture of 2-(3-{3-[4-acetyl-5-benzyloxy-2-ethylphenoxy]propoxy}-2-propylphenoxy)benzoic acid methyl ester (3.07 g, 5.04 mmol) and dimethylformamide dimethylacetal (0.9 mL, 7 mmol) in N,N-dimethylformamide (3 mL) was heated at 110-120 °C for 35 h. The mixture was cooled to room temperature and diluted with a mixture of ethyl acetate and 1 N hydrochloric acid. The organic layer was separated, washed twice with water, once with saturated sodium chloride solution, dried (sodium sulfate), filtered, and concentrated in vacuo. Chromatography (silica gel, 30~
ethyl acetate/70~ hexane to ethyl acetate) of the residue provided 2.1 g (63~) of the title compound as a yellow oil.
TOF MS ES exact mass calculated for C4~H46N07 (p+1): m/z - 652.3274. Found: 652.3270. IR (CHC13, cm ) 2965, 1720, 1605. Anal. Calcd for C4~H45N07: C, 73.71; H, 6.96; N, 2.15. Found: C, 73.72; H, 6.95; N, 2.18.
O
/ /
v w O~O O
COOMe N_N~H
/ /
O~O \ O
COOH
H. Preparation of 2-(3-t3-(5-benzyloxy-2-ethyl-4-(2H-pyrazol-3-yl)phenoxy]propoxy)-2-propylphenoxy)benzoic acid.
A solution of 2-(3-{3-[5-benzyloxy-4-(3-dimethylaminoacryloyl)-2-ethyl-phenoxy]propoxy}-2-propylphenoxy)benzoic acid methyl ester (550 mg, 0.843 mmol in methanol (30 mL) was treated with 1 M lithium hydroxide solution at 60 °C for 3 h. The mixture was cooled to room temperature and diluted with ethyl acetate and 0.5 M
hydrochloric acid. The organic layer was separated, washed with saturated sodium chloride solution, dried (sodium sulfate), filtered, and concentrated in vacuo. The residue was dissolved in methanol (15 mL) and treated with water (4 mL) and hydrazine monohydrate (0.50 mL, 7.7 mmol) at reflux for 3 h. The mixture was diluted with ethyl acetate and 1 N
hydrochloric acid. The organic layer was separated, washed with saturated sodium chloride solution, dried (sodium sulfate), filtered and concentrated in vacuo.
Chromatography (30~ ethyl acetate/69g hexane/1~ acetic acid) of the residue provided 350 mg (65~) of the title compound as the acetate salt. A portion of this material was free-based with sodium bicarbonate to provide an analytical -sample. 1H NMR (CDC13) 8 8.20 (dd, J = 8, 2 Hz, 1H), 7.55 (s, 1H), 7.44 (s, 1H), 7.38 (m, 5H), 7.15 (m, 2H), 6.78 (d, J = 8 Hz, 1H), 6.65 (d, J = 8 Hz, 1H), 6.61 (d, J.= 8 Hz, 1H), 6.58 (s, 1H), 6.55 (bs, 1H), 5.18 (s, 2H), 4.22 (t, J =
6 Hz, 2H), 4.17 (t, J = 6 Hz, 2H), 2.58 (m, 4H), 2.30 (quintet, J = 6 Hz, 2H), 1.47 (hextet, J = 8 Hz, 2H), 1.18 (t, J = 7 Hz, 3H), 0.88 (t, J = 8 Hz, 3H); TOF MS ES exact mass calculated for C37H39N206 (p+1): m/z = 607.2808.
Found: 607.2831. IR (CHC13, cm 1) 2965, 1739, 1604, 1454.
Anal. Calcd for C37H38N206: C, 73.25; H, 6.31; N, 4.62.
Found: C, 73.31; H, 6.30; N, 4.62.

N_N.H I w I w w I w I
/ 0~0 0 COOH
N_N.H H
i I
I ~ o'n'o ~ o ~
COOH
C. Preparation of 2-(3-~3-L2-ethyl-5-hydroxy-4-(2H-pyrazol-3-yl)phenoxy]propoxy?-2-propylphenoxy)benzoic acid.
A solution of 2-(3-{3-f5-benzyloxy-2-ethyl-4-(2H-pyrazol-3-yl)phenoxy]propoxy}-2-propylphenoxy)benzoic acid (300 mg, 0.490 mmol) in ethanethiol (2.5 mL) was treated with boron trifluoride etherate (2 mL) at room temperature for 3 h, at which time an additional portion of boron trifluoride etherate (1 mL) was added and stirring resumed for an additional 1 h. The mixture was diluted with diethyl ether and water.. The organic layer was separated, washed with water, dried (sodium sulfate), filtered, and concentrated in vacuo. Chromatography (silica gel, 15~ ethyl acetate/85~
hexane to 60~ ethyl acetate/40~ hexane) of the residue provided 60 mg (24~) of the title compound as a white solid.
1H NMR (CDC13) S 8.23 (d, J = 8 Hz, 1H), 7.61 (s, 1H), 7.42 (t, J = 7 Hz, 1H), 7.30 (s, 1H), 7.19 (d, J = Hz, 1H), 7 . 15 (d, J = 8 Hz, 1H) 6.81 (d, J = 8 Hz, 1H) 6.69 (d, , , J =

8 Hz, 1H), 6.61 (s, 1H), 6.60 (d, J = 8 Hz, 1H), 6.54 (s, 1H), 4.20 (m, 4H), 2.58 (m, 4H), 2.33 (quintet, J = 6 Hz, 2H), 1.48 (hextet, J = 8 Hz, 2H), 1.17 (t, J = 8 Hz, 3H), 0.86 (t, J = 7 Hz, 3H); TOF MS ES exact mass calculated for C3pH33N2o6 (P+1): m/z = 517.2339. Found: 517.2334.
IR (CHC13, cm 1) 2965, 1738, 1454.
Anal. Calcd for C3pH32N2~6~ C~ 69.75; H, 6.24; N, 5.42.
Found: C, 69.73; H, 6.33; N, 5.25.
Example 5 Preparation of 2-~3-[3-(2-Ethyl-5-hydroxy-4-isoxazol-5-yl-phenoxy)propoxy]-2-propylphenoxy)benzoic acid.

i i I
O~O w O w COOMe _O
o~O ~ o COOMe A. Preparation of 2-(3-[3-(5-benzyloxy-2-ethyl-4-isoxazol-5-yl-phenoxy)propoxy]-2-propylphenoxy)benzoic acid methyl ester.
A mixture of 2-(3-{3-[5-benzyloxy-4-(3-dimethylaminoacryloyl)-2-ethylphenoxy]propoxy}-2-propylphenoxy)benzoic acid methyl ester (280 mg, 0.43 mmol), hydroxylamine hydrochloride (75 mg, 1.1 mmol), and water (1 mL) in methanol (4 mL) was heated at reflux for 2 h. The mixture was cooled to room temperature and diluted with diethyl ether and water. The organic layer was separated, washed with saturated sodium chloride solution, dried (sodium sulfate), filtered, and concentrated in vacuo.
Chromatography (silica gel, 10~ ethyl acetate/90~ hexane) of the residue provided 202 mg (76~) of the title compound as a white solid. 1H NMR (CDC13) 8 8.20 (d, J = 2 Hz, 1H), 7.88 (dd, J = 9, 2 Hz, 1H), 7.79 (s, 1H), 7.40 (m, 7H), 7.08 (m, 2H) , 6.68 (d, J = 8 Hz, 1H) , 6.59 (s, 1H) , 6.58 (s, 1H) , 6.43 (d, J = 8 Hz, 1H), 5.15 (s, 2H), 4.21 (t, J = 6 Hz, 4H), 3.82 (s, 3H), 2.65 (m, 4H), 2.33 (quintet, J = 6 Hz, 2H), 1.56 (hextet, J = 8 Hz, 2H), 1.20 (t, J = 7 Hz, 3H), 0.90 (t, J = 7 Hz, 3H); TOF MS ES exact mass calculated for C38H40N07 (p+1): m/z = 622.2805. Found: 622.2817. IR
(CHC13, cm 1) 2964, 1720, 1461.
Anal. Calcd for C38H39N07: C, 73.41; H, 6.32; N, 2.25.
Found: C, 73.20; H, 6.34; N, 2.27.
i~ I ~ / / ~ / ~
/ O~O ~ O
COOMe OH
/ O~O O
COOMe B. Preparation of 2-(3-[3-(2-ethyl-5-hydroxy-4-isoxazol-5-yl-phenoxy)propoxy]-2-propylphenoxy)benzoic acid methyl ester.
A solution of 2-{3-[3-(5-benzyloxy-2-ethyl-4-isoxazol-5-yl-phenoxy)propoxy]-2-propylphenoxy}benzoic acid methyl ester (180 mg, 0.289 mmol) in ethanethiol (5 mL) was treated with boron trifluoride etherate (1.5 mL) at room temperature for 2 h, at which time an additional portion of boron trifluoride etherate (0.5 mL) was added and stirring resumed for an additional 1 h. The mixture was diluted with diethyl ether and water. The organic layer was separated, washed once with saturated sodium bicarbonate solution, once with saturated sodium chloride solution, dried (sodium sulfate), filtered, and concentrated in vacuo. Chromatography (silica gel, 15~ ethyl acetate/85~ hexane) of the residue provided 94 mg (61~) of the title compound as a colorless oil. H
NMR (CDC13) S 8.28 (d, J = 1 Hz, 1H), 7.88 (dd, J = 8, 2 Hz, 1H), 7.38 (t, J = 8 Hz,lH), 7.36 (s, 1H), 7.08 (t, J = 8 Hz, 1H), 7.05 (d, J = 8 Hz, 1H), 6.81 (d, J = 8 Hz, 1H), 6.67 (d, J = 8 Hz, 1H) , 6.50 (s, 1H) , 6.45 (s, 1H) , 6.43 (d, J =
8 Hz, 1H), 4.20 (m, 4H), 3.83 (s, 3H), 2.62 (m, 4H), 2.34 (quintet, J = 6 Hz, 2H), 1.54 (hextet, J = 8 Hz, 2H), 1.18 (t, J = 8 Hz, 3H), 0.90 (t, J = 7 Hz, 3H); TOF MS ES exact mass calculated for C31H34N07 (p+1): m/z = 532.2335.
Found: 532.2335. IR (CHC13, cm 1) 2964, 1715, 1601, 1461.
Anal. Calcd for C31H33N07: C, 70.04; H, 6.26; N, 2.63.
Found: C, 70.13; H, 6.35; N, 2.63.

N-O H
/~ il o'~o ~ o COOMe N-O H
O~O ~ ~ O w COOH
C. Preparation of 2-~3-I3-(2-ethyl-5-hydroxy-4-isoxazol-5-yl-phenoxy)propoxy]-2-propylphenoxy~benzoic acid.
To a solution of 2-(3-[3-(2-ethyl-5-hydroxy-4-isoxazol-5-yl-phenoxy)propoxy}-2-propylphenoxy}benzoic acid methyl ester _ (94 mg, 0.18 mmol) in methanol (3 mL) was added 1 M lithium hydroxide solution (1 mL) and the resulting mixture warmed at 60 °C for 3 h. The mixture was cooled to room temperature and concentrated in vacuo. The aqueous residue was diluted with water and the pH adjusted to ~4. The mixture was extracted three times with methylene chloride.
The combined organic extracts were dried (sodium sulfate), filtered, and concentrated in vacuo to provide 12 mg (13~) of the title compound as an off-white amorphous solid. H
NMR (CDC13) 8 8.26 (s, 1H), 8.20 (dd, J = 8, 1 Hz, 1H), 7.49 (t, J = 6 Hz, 1H), 7.36 (s, 1H), 7.18 (d, J = 8 Hz, 1H), 7.15 (d, J = 8 Hz, 1H), 7.02 (bs, 1H), 6.80 (d, J = 8 Hz, 1H), 6.69 (d, J = 8 Hz, 1H), 6.60 (d, J = 8 Hz, 1H), 6.50 (s, 1H), 6.46 (s, 1H), 4.22 (t, J = 6 Hz, 2H), 4.19 (t, J =
6 Hz, 2H); 2.57 (m, 4H), 2.34 (quintet, J = 6 Hz, 2H), 1.47 (hextet, J = 8 Hz, 2H), 1.16 (t, J = 8 Hz, 3H), 0.85 (t, J =
7 Hz, 3H); TOS MS ES exact mass calculated for C3~H32N07 (p+1): m/z = 518.2179. Found: 518.2175.
Anal. Calcd for C3~H31N07: C, 69.62; H, 6.04; N, 2.71.
Found: C, 69.57; H, 6.15; N, 2.74.
Example 6 preparation of 2-(3-(3-[2-Ethyl-5-hydroxy-4-(3H-(1,2,3]triazol-4-yl)phenoxy]propoxy?-2-propyl-phenoxy)benzoic acid.
r I , ~ I_ ~
I / O~CI + HO O COOMe Br I ~
~ ono ~ I o ~
COOMe A. Preparation of 2-~3-[3-(5-benzyloxy-4-bromo-2-ethylphenoxy)propoxy]-2-propylphenoxy]-benzoic acid methyl ester.
A mixture of 5-benzyloxy-4-bromo-1-(3-chloropropoxy)-2-ethylbenzene (1.19 g, 3.11 mmol), 2-(3-hydroxy-2-propylphenoxy)benzoic acid methyl ester (0.89 g, 3.1 mmol), potassium carbonate (1.29 g, 9.34 mmol), potassium iodide (0.52 g, 3.1 mmol), and methyl sulfoxide (2 mL) in 2-butanone (20 mL) was heated at reflux for 48 h. The mixture was cooled to room temperature, diluted with diethyl ether, and washed once with water. The organic layer was dried (sodium sulfate), filtered, and concentrated in vacuo.
Chromatography (silica gel, 6~ ethyl acetate/94~ hexane) of the residue provided 1.34 g (68~) of the title compound as a colorless oil. 1H NMR (CDC13) 8 7.91 (dd, J = 8, 2 Hz, 1H), 7.50 (d, J = 7 Hz, 2H), 7.38 (m, 5H), 7.15 (d, J = 8 Hz, 1H), 7.10 (d, J = 8 Hz, 1H), 6.83 (d, J = 8 Hz, 1H), 6.71 (d, J = 8 Hz, 1H), 6.55 (s, 1H), 6.48 (, J = 8 Hz, 1H), 5.16 (s, 2H), 4.21 (t, J = 6 Hz, 2H), 4.15 (t, J = 6 Hz, 2H), 3.83 (s, 3H), 2.68 (t, J = 8 Hz, 2H), 2.58 (q, J = 7 Hz, 2H), 2.31 (quintet, J = 6 Hz, 2H), 1.58 (hextet, J = 6 Hz, 2H) , 1. 17 (t, J = 7 Hz, 3H) , 0.93 (t, J = 7 Hz, 3H) .
- O
Br I ~
I ~ ono ~ I o COOMe o I
I~ ~I ~I
O~O \ O
COOMe B. Preparation of 2-i3-(3-(5-benzyloxy-2-ethyl-4-ethynylphenoxy)propoxy]-2-propyl-phenoxy~benzoic acid methyl ester.
A mixture of 2-{3-[3-(5-benzyloxy-4-bromo-2-ethylphenoxy)propoxy]-2-propylphenoxy}-benzoic acid methyl ester (1.50 g, 2.37 mmol), tri-n-butylethynyltin (0.82 mL, 2.8 mmol), and tetrakis(triphenylphosphine)palladium (0) (1.0 g, 0.95 mmol) in N,N-dimethylformamide (25 mL) was purged with argon and heated in a sealed tube at 120 °C for 24 h. The mixture was cooled to room temperature and filtered. The filtrate was diluted with ethyl acetate, washed four times with water, once with saturated sodium chloride solution, dried (sodium sulfate), filtered, and concentrated in vacuo. Chromatography (silica gel, 10~
ethyl acetate/90~ hexane) of the residue provided 532 mg (39~) of the title compound as a brown oil. H NMR (CDC13) 8 7.88 (dd, J = 8, 2 Hz, 1H), 7.79 (s, 1H), 7.20-7.50 (m, 6H), 7.10 (d, J 8 Hz, 1H),7.05 (d, J 8 Hz, 1H), 6.80 = =

(d, J Hz, 1H), 6.66 (d, J Hz, 1H),6.43 (m, 2H), = =

5.16 (s, 2H),4.17 (t, = Hz,. 2H), 4.11(t, J = 6 Hz, 2H), 3.83 (s, 3H), 3.23 (s, 1H), 2.64 (t, J = 8 Hz, 2H), 2.53 (q, J 7 2H), 2.27(qui ntet,J 6 Hz, 2H), 1.53 = Hz, =

(m, 2H), 1.13(t, J = Hz, 3H), 0.89 (t, J = 7 Hz, 3H); TOF

MS ES+ mass calcu lated C37H 3906(p+1): m/z =
exact for 579.2747. Found: 579.2739.
I/
/ /
I / 0~0 w I o w I
COOMe NN_N.H
I / O~O ~ I O ~ I
COOMe C. Preparation of 2-(3-~3-[5-benzyloxy-2-ethyl-4-(3H-[1,2,3]triazol-4-yl)phenoxy]-propoxy]-2-propylphenoxy)benzoic acid methyl ester.
A mixture of 2-{3-[3-(5-benzyloxy-2-ethyl-4-ethynylphenoxy)propoxy]-2-propyl-phenoxy}benzoic acid methyl ester (517 mg, 0.893 mmol) and trimethylsilyl azide (3.0 mL, 18 mmol) was heated in toluene (20 mL) in a sealed tube at 130 °C for 120 h. The mixture was cooled to room temperature and concentrated in vacuo. Chromatography (silica gel, 10~ ethyl acetate/90~ hexane to 50~ ethyl acetate/50~ hexane) of the residue provided 347 mg (88~
based upon recovered starting material) of the title compound as a brown solid. H NMR (CDC13) 8 8.10 (bs, 1H), 7.89 (dd, J = 8, 2 Hz, 1H), 7.76 (s, 1H), 7.40 (m, 7H), 7.10 (d, J = 8 Hz, 1H), 7.05 (d, J = 8 Hz, 1H), 6.79 (d, J = 8 Hz, 1H), 6.67 (d, J = 8 Hz, 1H), 6.62 (s, 1H), 6.43 (d, J =
8 Hz, 1H), 5.18 (s, 2H), 4.21 (m, 4H), 3.82 (s, 3H), 2.65 (m, 4H), 2.32 (quintet, J = 6 Hz, 2H), 1.56 (hextet, J = 8 Hz, 2H), 1.21 (t, J = 8 Hz, 3H), 0.90 (t, J = 7 Hz, 3H); TOF
MS ES exact mass calculated for C37H4~N306 (p+1): m/z =

622.2917. Found: 622.2946. IR (CHC13, cm ) 3400, 1721, 1602, 1453.
Anal. Calcd for C37H39N306: C, 71.48; H, 6.32; N, 6.76.
Found: C, 70.28; H, 6.07; N, 6.54.

NN-N'H p O~O ~ I O w COOMe ,H
N /
O
COOMe D. Preparation of 2-(3-(3-I2-ethyl-5-hydroxy-4-(3ii-[1,2,3]triazol-4-yl)phenoxy]-propoxy)-2-propyl-phenoxy)benzoic acid methyl aster.
A solution of 2-(3-{3-[5-benzyloxy-2-ethyl-4-(3H-[1,2,3]triazol-4-yl)phenoxy]propoxy}-2-propylphenoxy)benzoic acid methyl ester (330 mg, 0.531 mmol) in ethanethiol (9 mL) was treated with boron trifluoride etherate (2.0 mL,l6 mmol) for 1 h at room temperature and then with an additional portion of boron trifluoride etherate (1.0 mL) for 1 h. The mixture was diluted with diethyl ether and water. The organic layer was washed once with saturated sodium bicarbonate solution, once with saturated sodium chloride solution, dried (sodium sulfate), filtered, and concentrated in vacuo. Chromatography (silica gel, 30~ ethyl acetate/70~
hexane to 50~ ethyl acetate/50~ hexane) of the residue provided 180 mg (63~) of the title compound as a brown solid. 1H NMR (CDC13) 8 7.97 (s, 1H), 7.88 (dd, J = 8, 2 Hz, 1H), 7.37 (t, J = 8 Hz, 1H), 7.31 (s, 1H), 7.10 (d, J =
8 Hz, 1H), 7.05 (d, J = 8 Hz, 1H), 6.81 (d, J = 8 Hz, 1H), 6.67 (d, J = 8 Hz, 1H), 6.59 (s, 1H), 6.43 (d, J = 8 Hz, 1H), 4.20 (m, 4H), 3.83 (s, 3H), 2.63 (m, 4H), 2.34 (quintet, J = 6 Hz, 2H), 1.55 (hextet, J = 8 Hz, 2H), 1.19 (t, J = 8 Hz, 3H), 0.90 (t, J = 7 Hz, 3H); TOF MS ES exact mass calculated for C3~H34N3~6 (p+1): m/z = 532.2447.
Found: 532.2466. IR (CHC13, cm 1) 2964, 1718, 1453.
Anal. Calcd for C3~H33N3~6~ C. 67.78; H, 6.26; N, 7.90.
Found: C, 66.80; H, 6.02; N, 7.53.
H
,N_N. H
N ~
/ /
O~O ~ ~ O
COOMe ,N_N~H H
N ~
/ /
/ O~O
COOH
E. Preparation of 2-(3-~3-[2-ethyl-5-hydroxy-4-(3H-[1,2,3]triazol-4-yl)phenoxy]-propoxy)-2-propylphenoxy)benzoic acid.
A solution of 2-(3-{3-[2-ethyl-5-hydroxy-4-(3H-[1,2,3]triazol-4-yl)phenoxy]propoxy}-2-propylphenoxy)benzoic acid methyl ester (160 mg, 0.30 mmol) in methanol (5 mL) was treated 1 N lithium hydroxide solution (1.5 mL) at 60 °C for 3.5 h. The mixture was cooled to room temperature, diluted with water, and adjusted to ~pH 4. The resulting mixture was extracted three times with methylene chloride. The combined organic extracts were dried (sodium sulfate), filtered, and concentrated in vacuo to provide 134 mg (86~) of the title compound as a tan solid. H NMR (DMSO-d) 8 14 . 12 (bs, 1H) 10. 02 (bs, 98 (bs, . , 1H) , 8 .
1H) , 80 17 (bs, 1H), 7.77 (dd, 7, Hz, 1H), 7.60 (bs, 1H),7.47 (t, J
J = 2 =

8 Hz, 1H), 7.18 , 8 , , 7.14 (t, 8 Hz, 1H), (t J Hz 1H) J =
=

6.82 (d, J = 8 1H), 6.68 (d, J = 8 Hz, 1H),6.57 (s, Hz, 1H), 6.35 (d, J 8 1H), 4.22 (t, J = 6 Hz, 2H), 4.15 = Hz, (t, J = 6 Hz, 2H), 2.54 (m, 4H), 2.25 (quintet,J = 6 Hz, 2H), 1.45 (hextet,J 8 2H), 1.11 (t, J 7 Hz, 3H), = Hz, =

0.81 (t, J = 7 3H); TOF MS exact mass calculated Hz, ES

for C29H32N306 (p+1): m/z = 518.2291. Found: 518.2302.
IR (CHC13, cm 1) 2965, 1738, 1454.
Anal. Calcd for C29H31N306: C, 67.30; H, 6.04; N, 8.12.
Found: C, 67.15; H, 5.98; N, 7.93.
Example 7 Preparation of 2-(3-I3-(2-Ethyl-5-hydroxy-4-pyrrol-1-yl-phenoxy)propoxy]-2-propyl-phenoxy~benzoic acid methyl ester.

CN
OH I ~ OH
A. Preparation of 5-benzyloxy-2-ethyl-4-pyrrol-1-yl-phenol.
To a mixture of potassium nitrosodisulfonate (40.0 g, 149 mmol) and potassium hydrogen phosphate (10 g) in water (1.2 L) at room temperature was added a solution of 4-ethylbenzene-1,3-diol (10.0 g, 2.37 mmol) and potassium hydrogen phosphate (10.5 g) in water (150 mL). The mixture was stirred for 15 min and adjusted to pH ~3. The solution was extracted three times with diethyl ether. The organic layer was dried (sodium sulfate), filtered, and concentrated in vacuo. The residue was dissolved in acetonitrile (70 mL) and treated at room temperature with 65~ 3-pyrroline (12 mL). The resulting mixture was stirred for 1 h and concentrated in vacuo, dissolved in ethyl acetate and hexane, and filtered down a short column of silica gel. The resulting solution was concentrated in vacuo. The residue was dissolved in N,N-dimethylformamide (10 mL) and treated with benzyl bromide (0.85 mL, 7.1 mmol) and potassium carbonate (960 mg, 6.9 mmol) at room temperature for 15 h.
The mixture was diluted with ethyl acetate, washed four times with water, once with saturated sodium chloride solution, dried (sodium sulfate), filtered, and concentrated in vacuo. Chromatography (silica gel, ethyl acetate/hexane gradient) of the residue provided 316 mg (2~) of the title compound. TOF MS ES exact mass calculated for C19H20N02 (p+1): m/z = 294.1494. Found: 294.1471.
B. Preparation of 1-[2-benzyloxy-4-(3-chloropropoxy)-5-ethylphenyl]-1X-pyrrole.
O ~ ~ p \ N I / CN I /
OH / O~CI
A mixture of 5-benzyloxy-2-ethyl-4-pyrrol-1-yl-phenol (316 mg, 1.08 mmol), potassium carbonate (223 mg, 1.62 mmol), and 1-bromo-3-chloropropane (0.16 mL, 1.6 mmol) in N,N-dimethylformamide (5 mL) was stirred at room temperature for 18 h. The mixture was diluted with ethyl acetate and water, washed four times with water, once with saturated sodium chloride solution, dried (sodium sulfate), filtered, and concentrated in vacuo. Chromatography (silica gel, 5$ ethyl acetate/95~ hexane) of the residue provided 314 mg (79$) of the title compound as a colorless oil. TOF MS ES exact mass calculated for C22H25NC102 (p+1): m/z = 370.1574.
Found: 370.1548.
~/ ~~ /~
Ho / o / O~CI + COOMe CN I / /
/ O~O ~ ( O ~
COOMe C. Preparation of 2-(3-[3-(5-benzyloxy-2-ethyl-4-pyrrol-1-yl-phenoxy)propoxy]-2-propylphenoxy?benzoic acid methyl ester.
A mixture of 1-[2-benzyloxy-4-(3-chloropropoxy)-5-ethylphenyl]-1H-pyrrole (310 mg, 0.85 mmol) and sodium iodide (140 mg, 0.94 mol) in 2-butanone (5 mL) was heated at reflux for 6 h. The mixture was cooled to room temperature, filtered, and concentrated in vacuo. The residue was dissolved in N,N-dimethylformamide (7 mL) and treated with 2-(3-hydroxy-2-propylphenoxy)benzoic acid methyl ester (242 mg, 0.85 mmol) and potassium carbonate (129 g, 93 mmol) at room temperature for 15 h. The mixture was diluted with ethyl acetate and water, washed four times with water, once with saturated sodium chloride solution, dried (sodium sulfate), filtered, and concentrated in vacuo.
Chromatography (silica gel, 5~ ethyl acetate/95~ hexane) of the residue provided 196 mg (37~) of the title compound as a colorless oil. 1H NMR (CDC13) 8 7.86 (dd, J = 8, 2 Hz, 1H), 7.37 (dt, J = 8, 2 Hz, 1H), 7.30 (m, 5H), 7.07 (m, 3H), 6.84 (m, 2H), 6.79 (d, J = 8 Hz, 1H), 6.65 (d, J = 8 Hz, 1H), 6.58 (s, 1H) , 6.42 (d, J = 8 Hz, 1H) , 6.29 (m, 2H) , 4.92 (s, 2H), 4.17 (t, J = 6 Hz, 2H), 4.15 (t, J = 6 Hz, 2H), 3.83 (s, 3H), 2.65 (t, J = 8 Hz, 2H), 2.58 (q, J = 7 Hz, 2H), 2.30 (quintet, J = 6 Hz, 2H), 1.55 (hextet, J = 8 Hz, 2H), 1.16 (t, J = 7 Hz, 3H), 0.80 (t, J = 7 Hz, 3H); TOF MS ES
exact mass calculated for C39H42N06 (p+1): m/z = 620.3012.
Found: 620.3021.
/ /
O~O ~ ~ O
COOMe OH
/ O~O ~ ~ O ~
COOMe D. Preparation of 2-~3-[3-(2-ethyl-5-hydroxy-4-pyrrol-1-yl-phenoxy)propoxy]-2-propyl-phenoxy?benzoic acid methyl ester.
A solution of 2-{3-[3-(5-benzyloxy-2-ethyl-4-pyrrol-1-yl-phenoxy)propoxy]-2-propylphenoxy}benzoic acid methyl ester (195 mg, 0.315 mmol) in ethanethiol (5 mL) was treated with boron trifluoride etherate (1.3 mL, 9.5 mmol) at room temperature for 2.5 h. The mixture was diluted with diethyl ether and water. The organic layer was washed with saturated sodium bicarbonate solution, dried (sodium sulfate), filtered, and concentrated in vacuo.
Chromatography (silica gel, 10o ethyl acetate/90~ hexane) of the residue provided 39 mg (23~) of the title compound as a colorless oil. 1H NMR (CDC13) 8 7.89 (d, J = 8 Hz, 1H), 7.37 (t, J = 8 Hz, 1H) , 7.07 (m, 2H) , 6.98 (s, 1H) , 6.68 (m, 3H) , 6.65 (d, J = 8 Hz, 1H) , 6.57 (s, 1H) , 6.42 (d, .J = 8 Hz, 1H), 6.35 (m, 2H), 5.04 (bs, 1H), 4.19 (m, 2H), 3.83 (s, 3H), 2.64 (t, J = 8 Hz, 2H), 2.58 (q, J = 7 Hz, 2H), 2.32 (quintet, J = 6 Hz, 2H) , 1.55 (m, 2H) , 1. 14 (t, J = 7 Hz, 3H), 0.90 (t, J = 7 Hz, 3H); TOF MS ES exact mass calculated for C32H36N06 (p+1): m/z = 530.2543. Found:
530.2516.

Example 8 Preparation of 2-(3-{3-[4-(3-Hromo-11,2,4]thiadiazol-5-yl)-2-ethyl-5-hydroxyphenoxy]-propoxy?-2-propylphenoxy)benzoic acid.
Br I i i i I
I ~ ono ~ o COOMe O
,e I i , i o I ~ ono ~ I o ~
COOMe A. Preparation of 2-(3-t3-L5-benzyloxy-2-ethyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenoxy]propoxy~-2-propylphenoxy)benzoic acid methyl ester.
A mixture of 2-~3-[3-(5-benzyloxy-4-bromo-2-ethylphenoxy)propoxy]-2-propylphenoxy}-benzoic acid methyl ester (8.30 g, 13.1 mmol), triethylamine (5.2 mL, 39 mmol), and PdCl2(dppf) (320 mg, 0.39 mmol) in de-oxygenated toluene (80 mL) was treated with a 1 M solution of 4,4,5,5-tetramethyl-[1,3,2]dioxaborolane in tetrahydrofuran (20 mL, mmol) and heated at reflux for 6 h. The mixture was filtered down a short column of silica gel and the filtrate concentrated in vacuo. Chromatography (silica gel, 35~
20 ethyl acetate/65o hexane) of the residue provided a dark oil that was subjected to further chromatography (silica gel, hexane to 30~ ethyl acetate/70o hexane) to give 7.70 g (84~) of the title compound. 1H NMR (CDC13) 8 7.86 (dd, J = 8, 2 Hz, 1H), 7.60 (d, J = 8 Hz, 2H), 7.47 (s, 1H), 7.34 (m, 3H), 7.24 (t, J = 8 Hz, 1H), 7.09 (d, J = 9 Hz, 1H), 7.04 (d, J =
9 Hz, 1H), 6.79 (d, J = 9 Hz, 1H), 6.66 (d, J = 9 Hz, 1H), 6.47 (s, 1H), 6.43 (d, J = 8 Hz, 1H), 5.07 (s, 2H), 4.18 (m, 4H), 3.81 (s, 3H), 2.64 (t, J = 8 Hz, 2H), 2.56 (q, J = 7 Hz, 2H), 2.30 (quintet, J = 6 Hz, 2H), 1.53 (hextet, J = 8 Hz, 2H), 1.34 (s, 12H),1.14 (t, J = 7 Hz, 3H), 0.89 (t, J =
7 Hz, 3H); TOF MS ES exact mass calculated for C41H53NB08 (p + NH4): m/z = 698.3864. Found: 698.3889. IR (CHC13, cm 1) 2964, 1720, 1604, 1453.
Anal. Calcd for C41H49B08: C, 72.35; H, 7.26. Found: C, 72.30; H, 7.12.
O
,B ~ / , /
~I ~I
O O O
COOMe Br I/
/ /
COOMe B. Preparation of 2-(3-{3-[5-benzyloxy-4-(3-bromo-[1,2,4]thiadiazol-5-yl)-2-ethyl-phenoxy]propoxy~-2-propylphenoxy)benzoic acid methyl ester.

A mixture of 2-(3-{3-[5-benzyloxy-2-ethyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenoxy]propoxy}-2-propylphenoxy)benzoic acid methyl ester (310 mg, 0.46 mmol), 3-bromo-5-chloro-1,2,4-thiadiazole (120 mg, 0.60 mmol), cesium carbonate (300 mg, 0.92 mmol), and PdCl2(dppf) (20 mg, 0.024 mmol) in de-oxygenated toluene (10 mL) was heated at 100 °C for 15 h. The mixture was diluted with a solution of 35~ ethyl acetate/65~ hexane and filtered down a short column of silica gel. The filtrate was concentrated in vacuo. Chromatography (silica gel, hexane to 30~ ethyl acetate/70~ hexane) of the residue provided 232 mg (70~) of the title compound. 1H NMR (CDC13) 8 8.13 (s, 1H), 7.87 (dd, J = 8, 2 Hz, 1H), 7.44 (m, 2H), 7.37 (m, 4H), 7.08 (t, dJ = 8, 1 Hz, 1H), 7.04 (d, J = 9 Hz, 1H), 6.78 (d, J = 9 Hz, 1H), 6.66 (d, J = 9 Hz, 1H), 6.55 (s, 1H), 6.43 (d, J =
8 Hz, 1H), 5.28 (s, 2H), 4.21 (t, J = 6 Hz, 2H), 4.19 (t, J
- 6 Hz, 2H), 3.81 (s, 3H), 2.62 (m, 4H), 2.34 (quintet, J =
6 Hz, 2H), 1.55 (hextet, J = 8 Hz, 2H), 1.17 (t, J = 7 Hz, 3H), 0.88 (t, J = 7 Hz, 3H); MS ES m/e 717, 719.

Br S ~ i ~ \ ~ \ ~
~o o -o COOMe Br N H
.s ~ \ / ~ / ~
/ oho \ O \
COOH
C. Preparation of 2-(3-~3-[4-(3-bromo-[1,2,4]thiadiazol-5-yl)-2-ethyl-5-hydroxyphenoxy]propoxy~-2-propylphenoxy)benzoic acid.
A solution of 2-(3-(3-[5-benzyloxy-4-(3-bromo-[1,2,4]thiadiazol-5-yl)-2-ethyl-phenoxy]propoxy}-2-propylphenoxy)benzoic acid methyl ester (230 mg, 0.31 mmol) in ethanethiol (4 mL) was treated with boron trifluoride etherate (0.32 mL, 2.5 mmol) at room temperature for 6 h, at which time an additional portion of boron trifluoride etherate was added and stirring continued for 7 h. The reaction mixture was diluted with water, concentrated in vacuo, and extracted with diethyl ether. The residue was dissolved in methanol (5 mL) and treated with 1 N lithium hydroxide solution (2 mL) at 65 °C for 1 h. The mixture was concentrated in vacuo and the residue diluted with water and adjusted to ~pH 3 with 1 N hydrochloric acid. The resulting precipitate was collected via vacuum filtration and dissolved in dilute aqueous base. Reverse phase chromatography (1:1 acetonitrile/water) provided 43 mg (23~) of the title compound as a yellow solid. 1H NMR (DMSO-d6) 8 7.85 (s, 1H), 7.80 (dd, J = 8, 2 Hz, 1H), 7.45 (m, 2H), 7.15 (m, 3H), 6.83 (d, J = 9 Hz, 1H), 6.80 (d, J = 9 Hz, 1H), 6.62 (s, 1H), 6.35 (d, J = 9 Hz, 1H), 4.20 (m, 4H), 2.55 (m, 4H), 2.27 (quintet, J = 5 Hz, 2H), 1.44 (hextet, J = 8 Hz, 2H), 1.13 (t, J = 7 Hz, 3H), 0.81 (t, J = 7 Hz, 3H); MS ES
m/e 551 (p+NH4+-Br); IR (KBr, cm 1) 2900, 1696, 1603, 1461.
Anal. Calcd for C29H29BrN206S: C, 56.77; H, 4.76; N, 4.56.
Found: C, 56.63; H, 4.72; N, 3.98.
Example 9 Preparation of 2-i3-[3-(2-Ethyl-5-hydroxy-4-thiophen-2-yl-phenoxy)propoxy]-2-propyl-phenoxy~benzoic acid sodium salt.
A. Preparation of 2-i3-[3-(2-ethyl-5-hydroxy-4-thiophen-2-yl-phenoxy)propoxy]-2-propylphenoxy]benzoic acid methyl ester.
A mixture of 2-(3-{3-[5-benzyloxy-2-ethyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenoxy]propoxy}-2-propylphenoxy)benzoic acid methyl ester (300 mg, 0.44 mmol), 2-bromothiophene (110 mg, 0.66 mmol), cesium carbonate (300 mg, 2.17 mmol), and PdCl2(dppf) (20 mg, 0.024 mmol) in de-oxygenated toluene (10 mL) was heated at 105 °C for 66 h.
The mixture was cooled to room temperature and concentrated in vacuo. The residue was dissolved in methylene chloride and filtered down a short column of silica gel. The filtrate was concentrated in vacuo. Chromatography (silica gel, 30~ ethyl acetate/70~ hexane) of the residue provided an oil that was dissolved in ethanethiol (4 mL) and treated with boron trifluoride etherate (0.44 mL, 3.4 mmol) at room temperature for 3 h. The mixture was diluted with water and extracted with diethyl ether. The organic layer was dried (sodium sulfate), filtered, and concentrated in vacuo.
Chromatography (silica gel, hexane to 30~ ethyl acetate/70~
hexane) of the residue provided 120 mg (50~) of the title compound as a yellow film. 1H NMR (CDC13) 8 7.85 (dd, J =
8, 2 Hz, 1H), 7.35 (t, J = 8 Hz, 1H), 7.15 (d, J = 7 Hz, 1H), 7.03-7.15 (m, 5H), 6.80 (d, J = 9 Hz, 1H), 6.66 (d, J =
9 Hz, 1H), 6.51 (s, 1H), 6.42 (d, J = 8 Hz, 1H), 5.44 (bs, 1H), 4.18 (m, 4H), 3.82 (s, 3H), 2.62 (t, J = 8 Hz, 2H), 2.58 (q, J = 7 Hz, 2H), 2.54 (quintet, J = 6 Hz, 2H), 1.52 (hextet, J = 8 Hz, 2H), 1.16 (t, J = 7 Hz, 3H), 0.90 (t, J =
7 Hz, 3H); MS ES m/e 545 (p - 1).
B. Preparation of 2-~3-[3-(2-ethyl-5-hydroxy-4-thiophen-2-yl-phenoxy)propoxy]-2-propylphenoxy)benzoic acid sodium salt.
OH
I / ono ~ I o ~ I
COOMe off /I /I
/ o'~o ~ o COONa A solution of 2-{3-[3-(2-ethyl-5-hydroxy-4-thiophen-2-yl-phenoxy)propoxy]-2-propylphenoxy}benzoic acid methyl ester (120 mg, 0.22 mmol) in methanol (3 mL) was treated with 1 N

lithium hydroxide solution (0.5 mL) at room temperature for 1 h and then with an additional portion of 1 N lithium hydroxide solution (0.75 mL) for 18 h. The mixture was heated at 50 °C then concentrated in vacuo. The residue was acidified with dilute hydrochloric acid and extracted with diethyl ether. The organic layer was washed once with water and concentrated in vacuo. The residue was diluted with 1 N
sodium hydroxide solution (0.22 mL), diethyl ether, and toluene. The mixture was concentrated in vacuo, dissolved in methylene chloride, and concentrated in vacuo to provide 120 mg (98~) of the title compound as a green film. H NMR
(DMSO-d6) 8 7.71 = 8 Hz, (d, J 1H), 7.42 (m, 2H), 7.31 (m, 2H), 7.10(m, 2H), 6.99(m, 1H), 6.76 (t, J = 7 2H), Hz, 6.52 (s, 1H) , 6.30(d, J = 8 Hz, 1H) 4.16 (t, J 7 Hz, , =

2H), 4.07(t, J = Hz, 2H), 2.50 (m, 4H), 2.20 2H), 7 (m, 1.40 (m, 2H), 1.06 (t, J = 8 Hz, 3H), 0.77 (t, J 7 Hz, =

+ 1 - Na+). (CHC1 , cm 2900, 3H); MS (p IR 1) m/e 1738, 1604, 1454.
2 0 Exa~le 10 Preparation of 2-(3-{3-[2-Ethyl-5-hydroxy-4-(1-methyl-1S-pyrazol-4-yl)-phenoxy]propoxy?-2-propylphenoxy)benzoic acid.
I I
\ ~\
N-N N-N\
~H
A. Preparation of 4-iodo-1-methylpyrazole (Known compound:
RN 39806-90-1).
To a solution of 4-iodopyrazole (1.3 g, 6.8 mmol) in dioxane (10 mL) was added iodomethane (0.42 mL, 6.8 mmol) and the resulting mixture stirred at room temperature for 96 h. The mixture was concentrated in vacuo and the residue mixed with methylene chloride and filtered. The filtrate was concentrated in vacuo to provide 1.35 g (95~) of the title compound as a colorless oil. H NMR (CDC13) 8 7.47 (s, 1H), 7.38 (s, 1H), 3.90 (s, 3H).
H. Preparation of 2-(3-{3-[5-benzyloxy-2-ethyl-4-(1-methyl-iH-pyrazol-4-yl)phenoxy]-propoxyy-2-propylphenoxy)benzoic acid methyl aster.
A mixture of 2-(3-~3-[5-benzyloxy-2-ethyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-y1)phenoxy]propoxy}-2-propylphenoxy)benzoic acid methyl ester (1.00 g, 1.47 mmol), 4-iodo-1-methylpyrazole (450 mg, 2.16 mmol), cesium carbonate (1.20 g, 3.62 mmol), and PdCl2(dppf) (72 mg, 0.088 mmol) in de-oxygenated toluene (35 mL) was heated at 100 °C
for 24 h. Additional portions of 4-iodo-1-methylpyrazole (~30 mg) and PdCl2(dppf) (~30 mg) were added and heating continued at 100 °C for 40 h. The mixture was cooled to room temperature, concentrated in vacuo, diluted with methylene chloride, and filtered down a short plug of silica gel. The filtrate was concentrated in vacuo.
Chromatography (silica gel, 35~ ethyl acetate/65~ hexane to 65~ ethyl acetate/35~ hexane) of the residue provided 710 mg (76~) of the title compound. 1H NMR (CDC13) 8 7.86 (dd, J =
8, 2 Hz, 1H), 7.80 (s, 1H), 7.69 (s, 1H), 7.37 (m, 6H), 7.28 (s, 1H), 7.09 (d, J = 9 Hz, 1H), 7.04 (d, J = 9 Hz, 1H), 6.78 (d, J = 9 Hz, 1H), 6.67 (d, J = 9 Hz, 1H), 6.56 (s, 1H), 6.42 (d, J = 8 Hz, 1H), 5.08 (s, 2H), 4.18 (t, J = 6 Hz, 2H), 4.15 (t, J = 6 Hz, 2H), 3.85 (s, 3H), 3.81 (s, 3H), 2.63 (t, J 8 Hz, 2H), 2.59 (q, J = 7 Hz, 2H), 2.30 =

(quintet, 6 Hz, 2H), 1.55 (hextet, J = 8 Hz, 2H), 1.23 J =

(t, J = 7 3H), 0.89 (t, = 7 Hz, 3H).
Hz, J

N, -N ~ ~ ~ i i ~I ~I
~o o _o COOMe N, H
-N ~
ono ~ o COOH
C. preparation of 2-(3-~3-L2-ethyl-5-hydroxy-4-(1-methyl-1H-pyrazol-4-yl)-phenoxylpropoxy?-2-propylphenoxy)benzoic acid.
A solution of 2-(3-{3-[5-benzyloxy-2-ethyl-4-(1-methyl-1H-pyrazol-4-yl)phenoxy]propoxy}-2-propylphenoxy)benzoic acid methyl ester (710 mg, 1.12 mmol) in ethanethiol (5 mL) was treated with boron trifluoride etherate (1.42 mL, 11.2 mmol) at room temperature for 20 h. The reaction mixture was diluted with water, concentrated in vacuo, and extracted with diethyl ether. The organic layer was dried (magnesium sulfate), filtered, and concentrated in vacuo. The residue was triturated twice with hexane and the residue dissolved in methanol (5 mL). This solution was treated with 1 N
lithium hydroxide solution (5 mL) at ~95 °C for 2 h. The mixture was concentrated in vacuo and the residue diluted with water, washed twice with diethyl ether, and the aqueous layer acidified with 1 N hydrochloric acid. The resulting solution was extracted with diethyl ether. The organic layer was dried (magnesium sulfate), filtered, and concentrated in vacuo. Chromatography (silica gel, 10~
methanol/90~ methylene chloride) provided 338 mg (57~) of the title compound as a tan foam. 1H NMR (DMSO-d6) 8 12.85 (bs, 1H), 9.50 (bs, 1H), 7.98 (s, 1H), 7.78 (m, 2H), 7.48 (dt, J = 8, 2 Hz, 1H), 7.44 (s, 1H), 7.18 (t, J = 8 Hz, 1H), 7 .13 (t, J = 9 Hz, 1H) , 6.79 (d, J = 9 Hz, 1H) , 6.77 (d, J =
9 Hz, 1H), 6.53 (s, 1H), 6.35 (d, J = 9 Hz, 1H), 4.20 (t, J
- 6 Hz, 2H), 4.08 (t, J = 6 Hz, 2H), 3.85 (s, 3H), 2.50 (m, 4H), 2.24 (quintet, J = 5 Hz, 2H), 1.45 (hextet, J = 8 Hz, 2H), 1.09 (t, J = 7 Hz, 3H), 0.82 (t, J = 7 Hz, 3H); MS ES
m/e 531 (p+1); IR (KBr, cm 1) 2961, 1697, 1602, 1460, 1222.
Anal. Calcd for C31H34N206: C, 70.17; H, 6.46; N, 5.28.
Found: C, 69.27; H, 6.08; N, 4.63.

Example 11 Preparation of 2-{3-[3-(2-Ethyl-5-hydroxy-4-thiazol-2-yl-phenoxy)propoxy]-2-propyl-phenoxy?benzoic acid.
O O
O-B ~ I / / / ~ N
~~ Br ---~O O ~O
COOMe O I w / / /
O
COOMe A. Preparation of 2-{3-[3-(5-benzyloxy-2-ethyl-4-thiazol-2-yl-phenoxy)propoxy]-2-propylphenoxy)benzoic acid methyl ester.
A mixture of 2-(3-(3-[5-benzyloxy-2-ethyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenoxy]propoxy}-2-propylphenoxy)benzoic acid methyl ester (960 mg, 1.41 mmol), 2-bromothiazole (0.25 mL, 2.8 mmol), cesium carbonate (1.15 g, 3.52 mmol), and PdCl2(dppf) (35 mg, 0.040 mmol) in de-oxygenated toluene (35 mL) was heated at 60 °C for 16 h then at 100 °C for 7 h. Additional portions of 2-bromothiazole (0.13 mL) and PdCl2(dppf) (~30 mg) were added and heating continued at 100 °C for 72 h. The mixture was cooled to room temperature, concentrated in vacuo, diluted with methylene chloride, and filtered down a short plug of silica gel. The filtrate was concentrated in vacuo.

Chromatography (silica gel, hexane to 35~ ethyl acetate/65~
hexane) of the residue provided 282 mg (31~) of the title compound. 1H NMR (CDC13) S 8.20 (s, 1H), 7.86 (dd, J = 8, 1 Hz, 1H), 7.82 (d, J = 3 Hz, 1H), 7.49 (d, J = 7 Hz, 2H), 7.35 (m, 4H), 7.23 (d, J = 3 Hz, 1H), 7.09 (d, J = 9 Hz, 1H), 7.04 (d, J = 9 Hz, 1H), 6.78 (d, J = 9 Hz, 1H), 6.65 (d, J = 9 Hz, 1H), 6.57 (s, 1H), 6.42 (d, J = 8 Hz, 1H), 5.24 (s, 2H), 4.17 (m, 4H), 3.81 (s, 3H), 2.63 (m, 4H), 2.33 (quintet, J = 6 Hz, 2H), 1.55 (hextet, J = 8 Hz, 2H), 1.19 (t, J = 7 Hz, 3H), 0.88 (t, J = 7 Hz, 3H).
I~
~I ~I
~o o ~o COOMe ~N H
I ~ ono ~ I o ~ I
COOMe B. Preparation of 2-~3-[3-(2-ethyl-5-hydroxy-4-thiazol-2-yl-phenoxy)propoxy]-2-propylphenoxy)benzoic acid methyl ester.
A solution of 2-{3-[3-(5-benzyloxy-2-ethyl-4-thiazol-2-yl-phenoxy)propoxy]-2-propylphenoxy)benzoic acid methyl ester (282 mg, 0.442 mmol) in ethanethiol (3 mL) was treated with boron trifluoride etherate (0.56 mL, 4.4 mmol) at r~om temperature for 3 h. The reaction mixture was diluted with water, concentrated in vacuo, and extracted with diethyl ether. The organic layer was dried (magnesium sulfate), filtered, and concentrated in vacuo. Chromatography (silica gel, ethyl acetate/hexane) provided 107 mg (44~) of the title compound. 1H NMR (CDC13) 8 7.88 (dd, J = 8, 2 Hz, 1H), 7.80 (d, J = 4 Hz, 1H), 7.35 (dt, J = 8, 2 Hz, 1H), 7.28 (d, J = 4 Hz, 1H) , 7.24 (s, 1H) , 7.09 (dt, J = 9, 2 Hz, 1H), 7.05 (t, J = 9 Hz, 1H), 6.79 (d, J = 9 Hz, 1H), 6.66 (d, J = 9 Hz, 1H) , 6. 61 (s, 1H) , 6.42 (d, J = 9 Hz, 1H) , 4.24 (t, J = 6 Hz, 2H), 4.18 (t, J = 6 Hz, 2H), 3.81 (s, 3H), 2.63 (t, J = 7 Hz, 2H), 2.58 (q, J = 7 Hz, 2H), 2.34 (quintet, J = 6 Hz, 2H), 1.52 (hextet, J = 8 Hz, 2H), 1.17 (t, J = 7 Hz, 3H), 0.88 (t, J = 7 Hz, 3H); MS ES m/e 548 (p+1) .
__. ~N H
S
O~O O
COOMe ~N H
S ~ W
O~O O
COOH
C. Preparation of 2-~3-[3-(2-ethyl-5-hydroxy-4-thiazol-2-yl-phenoxy)propoxy]-2-propylphenoxy~benzoic acid.
2-{~3-(3-(2-Ethyl-5-hydroxy-4-thiazol-2-yl-phenoxy)propoxy]-2-propylphenoxy}benzoic acid methyl ester (107 mg, 0.196 mmol) was dissolved in a 1:1 solution of methanol/dioxane (3 mL) and treated with 1 N lithium hydroxide solution (1 mL) at 60 °C for 2 h. The mixture was concentrated in vacuo and the residue diluted with water, washed twice with diethyl ether, and the aqueous layer acidified with 1 N hydrochloric acid. The resulting solution was extracted twice with methylene chloride and the combined organic layers dried (magnesium sulfate), filtered, and concentrated in vacuo.
Trituration (hexane) of the residue provided 72 mg (69$) of the title compound as a tan powder. 1H NMR (CDC13) S 8.22 (dd, J = 8, 2 Hz, 1H), 7.70 (d, J = 4 Hz, 1H), 7.41 (dt, J =
8, 2 Hz, 1H), 7.35 (s, 1H), 7.18 (m, 3H), 6.82 (d, J = 9 Hz, 1H), 6.69 (d, J = 9 Hz, 1H), 6.62 (d, J = 9 Hz, 1H), 6.55 (s, 1H), 4.22 (t, J = 6 Hz, 2H), 4.21 (t, J = 6 Hz, 2H), 2.57 (m, 4H), 2.35 (quintet, J = 6 Hz, 2H), 1.49 (hextet, J
- 8 Hz, 2H), 1.18 (t, J = 7 Hz, 3H), 0.86 (t, J = 7 Hz, 3H);
MS ES+ m/e 534 (p+1); IR (KBr, cm 1) 2957, 1695, 1599, 1457.
Anal. Calcd for C3~H31N06S: C, 67.52; H, 5.86; N, 2.62.
Found: C, 67.44; H, 5.95; N, 2.55.

Example 12 Preparation of 2-(3-(3-[~4-(3,5-Dimethylisoxazol-4-yl)-2-ethyl-5-hydroxyphenoxy]propoxy)-2-propylphenoxy)benzoic acid sodium salt.
O O
I ~N
O,s ~ ~ / / ~ / ~ -~ \
/ O'~O ~ O ~ O
COOMe NO ~ O
/
~O O ~O
COOMe OH
N~ I
O~O ~ ~ O
COONa A mixture of 2-(3-{3-[5-benzyloxy-2-ethyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenoxy]propoxy}-2-propylphenoxy)benzoic acid methyl ester (305 mg, 0.448 mmol), 3,5-dimethyl-4-iodoisoxazole (110 mg, 0.493 mmol), cesium carbonate (293 mg, 0.899 mmol), and PdCl2(dppf) (15 mg, 0.018 mmol) in de-oxygenated toluene (10 mL) was heated at 95 °C for 10 h. Additional portions of 3,5-dimethyl-4-iodoisoxazole (110 mg), cesium carbonate (260 mg), and PdCl2(dppf) (~15 mg) were added and heating continued at 110 °C for 20 h. The mixture was cooled to room temperature, concentrated in vacuo, diluted with methylene chloride, and filtered down a short plug of silica gel with 20o ethyl acetate/80~ hexane. The filtrate was concentrated in vacuo.
The resulting colorless oil was dissolved in methylene chloride (4 mL), cooled to 0 °C, and treated with iodotrimethylsilane (0.40 mL, 2.7 mmol). The resulting mixture was allowed to warm to room temperature and stirred for 18 h. An additional portion of iodotrimethylsilane (0.70 mL) was added and stirring continued for 72 h. The mixture was poured into dilute sodium thiosulfate solution.
The organic layer was separated, washed with water, dried (sodium sulfate), filtered, and concentrated in vacuo. The resulting foam was dissolved in a 1:1 mixture of tetrahydrofuran/1 N hydrochloric acid (5 mL) and stirred at room temperature for 18 h. The mixture was concentrated in vacuo and treated with 1 equivalent 1 N sodium hydroxide solution in ether. The resulting mixture was concentrated in vacuo to provide 59 mg (23~) of the title compound as an off-white solid. 1H NMR (DMSO-d6) 8 7.40 (dd, J = 9, 2 Hz, 1H), 7.13 (dt, J = 8, 2 Hz, 1H), 6.97 (m, 2H), 6.79 (s, 1H), 6.68 (d, J = 9 Hz, 1H), 6.65 (d, J = 9 Hz, 1H), 6.60 (s, 1H), 6.21 (d, J = 8 Hz, 1H), 4.19 (t, J = 6 Hz, 2H), 4.01 (t, J = 6 Hz, 2H) , 2.66 (t, J = 8 Hz, 2H) , 2.48 (q, J = 8 Hz, 2H), 2.24 (s, 3H), 2.17 (quintet, J = 6 Hz, 2H), 2.07 (s, 3 H), 1.49 (hextet, J = 8 Hz, 2H), 1.07 (t, J = 7 Hz, 3H), 0.85 (t, J = 7 Hz, 3H); TOF MS ES exact mass calculated for C32H36N07 (p+1): m/z = 546.2492. Found:

546.2514; IR (KBr, cm ) 3400, 1605, 1460.

Example 13 Preparation of 2-~3-[3-(2-Ethyl-4-furan-2-yl-5-hydroxyphenoxy)propoxy]-2-propylphenoxy?-benzoic acid sodium salt.
Br I ~
~ ono w I o w COOMe H
Br I ~ ~ I ~ I
O
COOMe A. Preparation of 2-(3-[3-(4-bromo-2-ethyl-5-hydroxyphenoxy)propoxy]-2-propylphenoxy~benzoic acid methyl ester.
A solution of 2-{3-[3-(5-benzyloxy-4-bromo-2-ethylphenoxy)propoxy]-2-propylphenoxy}-benzoic acid methyl ester (2.50 g, 3.95 mmol) in methylene chloride (40 mL) was cooled to -70 °C and treated with boron tribromide (0.25 mL, 2.6 mmol). After 25 min the mixture was poured into cold water and the resulting mixture extracted with methylene chloride. The combined organic extracts were washed once with water, once with saturated sodium chloride solution, dried (sodium sulfate.), filtered, and concentrated in vacuo to provide 1.1 g (520) of the title compound as a pale yellow oil. 1H NMR (CDC13) 8 7.89 (d, J = 9 Hz, 1H), 7.38 (t, J = 8 Hz, 1H), 7.18 (s 1H), 7.12 (d, J = 9 Hz, 1H), 7.08 (d, J = 2 Hz, 1H), 6.81 (d, J = 9 Hz, 1H), 6.68 (d, J = 9 Hz, 1H), 6.56 (s, 1H), 6.46 (d, J = 9 Hz, 1H), 5.40 (s, 1H), 4.18 (t, J = 6 Hz, 2H), 4.11 (t, J = 6 Hz, 2H), 3.84 (s, 3H), 2.65 (t, J = 8 Hz, 2H), 2.54 (q, J = 7 Hz, 2H), 2.32 (quintet, J = 6 Hz, 2H), 1.54 (hextet, J = 8 Hz, 2H), 1.13 (t, J = 7 Hz, 3H), 0.89 (t, J = 7 Hz, 3H); MS ES m/z = 541 (M - H) , 543 (M - H + 2 ) .
H
Br ~
~ O~O ~ I O
COOMe TBS
Br ~
O~O w I O
COOMe B. Preparation of 2-(3-{3-[4-bromo-5-(tert-butyldimethylsilanyloxy)-2-ethylphenoxy]-propoxy}-2-propylphenoxy)benzoic acid methyl ester.
A solution of 2-{3-[3-(4-bromo-2-ethyl-5-hydroxyphenoxy)propoxy]-2-propylphenoxy}benzoic acid methyl ester (1.00 g, 1.84 mmol) in methylene chloride (20 mL) was treated with imidazole (0.19 g, 2.8 mmol) and tert-butyldimethylsilyl chloride (0.388 g, 2.57 mmol) at room temperature for 2 h. The mixture was poured into water and the organic layer separated, washed once with water, once with saturated sodium chloride solution, filtered through a short pad of silica gel, and concentrated in vacuo to provide 1.1 g (910) of the title compound as a colorless oil. 1H NMR (CDC13) 8 7.88 (d, J = 9 Hz, 1H), 7.38 (t, J =
8 Hz, 1H), 7.22 (s 1H), 7.12 (d, J = 9 Hz, 1H), 7.08 (d, J =
2 Hz, 1H), 6.80 (d, J = 9 Hz, 1H), 6.69 (d, J = 9 Hz, 1H), 6.45 (d, J = 9 Hz, 1H), 6.40 (s, 1H), 4.20 (t, J = 6 Hz, 2H), 4.11 (t, J = 6 Hz, 2H), 3.83 (s, 3H), 2.64 (t, J = 8 Hz, 2H), 2.54 (q, J = 7 Hz, 2H), 2.32 (quintet, J = 6 Hz, 2H), 1.54 (hextet, J = 8 Hz, 2H), 1.13 (t, J = 7 Hz, 3H), 1.03 (s, 9H), 0.89 (t, J = 7 Hz, 3H), 0.23 (s, 6H).
OTBS
Br I ~
O
COOMe OH
O, O~O ~ O
COOMe C. Preparation of 2-~3-[3-(2-ethyl-4-furan-2-yl-5-hydroxyphenoxy)propoxy]-2-propyl-phenoxy~benzoic acid methyl ester.
A mixture of 2-(3-~3-[4-bromo-5-(tert-butyldimethylsilanyloxy)-2-ethylphenoxy]propoxy}-2-propylphenoxy)benzoic acid methyl ester (1.05 g, 1.60 mmol), furan-2-boronic acid (0.358 g, 3.20 mmol), tetrakis(triphenylphosphine)palladium(0) (0.185 g, 0.160 mmol), and 2 M aqueous sodium carbonate solution (8 mL) in tetrahydrofuran (20 mL) was heated at reflux for 18 h. The mixture was cooled to room temperature, diluted with water, and extracted with ethyl acetate. The organic layer was separated, washed once with water, once with saturated sodium chloride solution, dried (sodium sulfate), filtered, and concentrated in vacuo. Chromatography (silica gel, 100 ethyl acetate/90~ hexane) of the residue provided 0.8 g (94~) of the title compound as a colorless oil. H NMR
(CDC13) 8 7.90 (d, J = 9 Hz, 1H), 7.48 (s, 1H), 7.38 (t, J =
8 Hz, 1H), 7.21 (s 1H), 7.13 (s, 1H), 7.10 (d, J = 9 Hz, 1H), 7.07 (d, J = 2 Hz, 1H), 6.81 (d, J = 9 Hz, 1H), 6.69 (d, J = 9 Hz, 1H), 6.52 (m, 3H), 6.44 (d, J = 9 Hz, 1H), 4.20 (m, 4H), 3.83 (s, 3H), 2.67 (t, J = 8 Hz, 2H), 2.59 (q, J = 7 Hz, 2H), 2.32 (quintet, J = 6 Hz, 2H), 1.55 (hextet, J
- 8 Hz, 2H), 1.18 (t, J = 7 Hz, 3H), 0.91 (t, J = 7 Hz, 3H); MS ES m/z = 589 (p + Ac0 ).
Anal. Calcd for C32H34~7~ C. 72.43; H, 6.46. Found: C, 72.21; H, 6.15.
OH
O, O~O ~ O
COOMe H
O, ~ ~ ~ ~ ~
O~O \ O \
COONa D. Preparation of 2-(3-[3-(2-ethyl-4-furan-2-yl-5-hydroxyphenoxy)propoxy]-2-propylphenoxy)benzoic acid sodium salt.
2-{3-[3-(2-Ethyl-4-furan-2-yl-5-hydroxyphenoxy)propoxy]-2-propylphenoxy}benzoic acid methyl ester (250 mg, 0.47 mmol) was dissolved in tetrahydrofuran (4 mL) and treated with 1 N
lithium hydroxide solution (2 mL) at 50 °C for 16 h. The mixture was concentrated in vacuo and the residue diluted with water and extracted twice with ethyl acetate. The combined organic extracts were washed once with water, once with saturated sodium chloride solution, dried (sodium sulfate), filtered, and concentrated in vacuo. The residue was dissolved in ethyl acetate and shaken with 1 N
hydrochloric acid. The organic layer was dried (sodium sulfate), filtered, and concentrated in vacuo. The residue was dissolved in diethyl ether and treated with 1 N aqueous sodium hydroxide solution (0.32 mL). The mixture was concentrated in vacuo and azeotroped successively with diethyl ether, chloroform, and diethyl ether and dried to provide 168 mg (66~) of the title product as a cream solid.
1H NMR (DMSO-d6) 8 7.56 (s, 1H), 7.44 (d, J = 8 Hz, 1H), 7.35 (s, 1H), 7.13 (m, 1H), 6.97 (m, 2H), 6.77 (d, J = 2 Hz, 1H), 6.65 (m, 4H), 6.48 (d, J = 2 Hz, 1H), 6.24 (d, J = 9 Hz, 1H), 4.15 (t, J = 6 Hz, 2H), 3.96 (t, J = 6 Hz, 2H), 2.66 (t, J = 8 Hz, 2H), 2.42 (q, J = 7 Hz, 2H), 2.13 (quintet, J = 6 Hz, 2H), 1.48 (hextet, J = 8 Hz, 2H), 1.09 (t, J = 7 Hz, 3H), 0.84 (t, J = 7 Hz, 3H); TOF MS ES
exact mass calculated for C31H33O7 (p+1): m/z = 517.2226.

Found: 517.2230. IR (KBr, cm ) 3400, 2961, 1599, 1460.

Example 14 Preparation of 2-(3-(3-[2-Ethyl-5-hydroxy-4-furan-3-yl]phenoxy]propoxy~-2-propylphenoxy)benzoic acid.
OTBS
Br ~ / /
/ Ono ~ I o ~
COOMe H
O ~
I~ /I /I
/ O~O \ O
COOMe A. Preparation of 2-~3-[3-(2-ethyl-4-furan-3-yl-5-hydroxyphenoxy)propoxy]-2-propyl-phenoxy~benzoic acid methyl ester.
A mixture of 2-(3-{3-[4-bromo-5-(tert-butyldimethylsilanyloxy)-2-ethylphenoxy]propoxy}-2-propylphenoxy)benzoic acid methyl ester (2.10 g, 3.19 mmol), furan-3-boronic acid (0.722 g, 6.45 mmol), tetrakis(triphenylphosphine)palladium(0) (0.37 g, 0.32 mmol), and 2 M aqueous sodium carbonate solution (16 mL) in tetrahydrofuran (30 mL) was heated at reflux for 48 h. The mixture was cooled to room temperature, diluted with water, and extracted with ethyl acetate. The organic layer was separated, washed once with water, once with saturated sodium chloride solution, dried (sodium sulfate), filtered, and concentrated in vacuo. Chromatography (silica gel, 15~
ethyl acetate/85~ hexane) of the residue provided 0.29 g (17~) of the title compound as a yellow oil. TOF MS ES
exact mass calculated for C32H3507 (p+1): m/z = 531.2383.
Found: 531.2396.
H
O ~
/ /
O~O ~ ~ O
COOMe H
O ~
/
/ O~O \ O \
COOH
B. Preparation of 2-~3-[3-(2-ethyl-4-furan-3-yl-5-hydroxyphenoxy)propoxy]-2-propylphenoxy?benzoic acid sodium salt.
2-{3-[3-(2-Ethyl-4-furan-3-yl-5-hydroxyphenoxy)propoxy]-2-propylphenoxy}benzoic acid methyl ester (170 mg, 0.32 mmol) was dissolved in tetrahydrofuran (4 mL) and methanol (1 mL) and treated with 1 N lithium hydroxide solution (4 mL) at 50 °C for 2 h. The mixture was concentrated in vacuo and the residue acidified with hydrochloric acid and the resulting mixture extracted twice with ethyl acetate. The combined organic extracts were washed once with water, once with saturated sodium chloride solution, dried (sodium sulfate), filtered, and concentrated in vacuo. Chromatography (silica gel, 2~ methanol/98% chloroform) of the residue gave 45 mg of material that was again submitted to chromatography (silica gel, 1o methanol/99~ chloroform) to provide 25 mg (15~) of the title compound as an oil.
TOF MS ES exact mass calculated for C31H3307 (p+1): m/z =
517.226. Found: 517.2230.
Example 15 Preparation of 2-(3-(3-[2-Ethyl-5-hydroxy-4-(tetrahydrofuran-3-yl)phenoxy]propoxy)-2-propylphenoxy)benzoic acid sodium salt hemihydrate.
° I
Br ~~ / /
I / O~O ~ I O ~ I
COOMe \~ o I /
I~ /I /I
/ o'~o ~ o COOMe A. Preparation of 2-~3-[3-(5-benzyloxy-2-ethyl-4-furan-3-yl-phenoxy)propoxy]-2-propylphenoxy}benzoic acid methyl aster.
A mixture of 2-{3-[3-(5-benzyloxy-4-bromo-2-ethylphenoxy)propoxy]-2-propylphenoxy}-benzoic acid methyl ester (3.00 g, 4.73 mmol), furan-3-boronic acid (1.06 g, 9.47 mmol), tetrakis(triphenylphosphine)palladium(0) (0.54 g, 0.47 mmol), and 2 M aqueous sodium carbonate solution (20 mL) in te-trahydrofuran (40 mL) was heated at 100 °C for 48 h. The mixture was cooled to room temperature, diluted with water, and extracted with ethyl acetate. The organic layer was separated, washed once with water, once with saturated sodium chloride solution, dried (sodium sulfate), filtered, and concentrated in vacuo. Chromatography (silica gel, 10~
ethyl acetate/90~ hexane) of the residue provided 1.9 g (65~) of the title compound as a yellow oil. H NMR (CDC13) 8 7.88 (dd, J = 8, 2 Hz, 1H), 7.87 (s, 1H), 7.40 (m, 7H), 7.26 (s 1H), 7.05 (m, 2H), 6.80 (d, J = 9 Hz, 1H), 6.76 (d, J = 2 Hz, 1H), 6.67 (d, J = 9 Hz, 1H), 6.60 (s, 1H), 6.43 (d, J = 9 Hz, 1H), 5.11 (s, 2H), 4.18 (m, 4H), 3.83 (s, 3H), 2.66 (t, J = 8 Hz, 2H), 2.62 (q, J = 7 Hz, 2H), 2.30 (quintet, J = 6 Hz, 2H), 1.57 (hextet, J = 8 Hz, 2H), 1.20 (t, J = 7 Hz, 3H), 0.92 (t, J = 7 Hz, 3H); MS ES m/z = 621 (p + 1); IR (CHC13, cm ) 3000, 1727, 1603, 1461.
O
/ O~O \ O
COOMe O H
/ O~O \ ~ O ~
COOMe B. Preparation of 2-(3-(3-[2-ethyl-5-hydroxy-4-(tetrahydrofuran-3-yl)phenoxy]-propoxy~-2-propylphenoxy)benzoic acid methyl ester.
A solution of 2-{3-[3-(5-benzyloxy-2-ethyl-4-furan-3-yl-phenoxy)propoxy]-2-propylphenoxy}benzoic acid methyl ester (1.8 g, 2.9 mmol) in ethyl acetate (40 mL) was treated with 10~ palladium-on-carbon (0.39 g) and hydrogenated at 48 psi and 45 °C for 72 h. The mixture was cooled to room TM
temperature, filtered through Celite , and the filtrate concentrated in vacuo to provide 1.2 g (770) of the title compound as a colorless oil. 1H NMR (CDC13) 8 7.88 (dd, J =
8, 2 Hz, 1H), 7.57 (dt, J = 8, 2 Hz, 1H), 7.09 (d, J = 9 Hz, 1H), 7.04 (d, J = 9 Hz, 1H), 6.81 (d, J = 9 Hz, 1H), 6.80 (s, 1H), 6.67 (d, J = 9 Hz, 1H), 6.44 (d, J = 9 Hz, 1H), 6.43 (s, 1H), 4.19 (m, 3H), 4.10 (m, 2H), 4.02 (dd, J = 12, 3 Hz, 1H), 3.88 (dd, J = 12, 8 Hz, 1H), 3.84 (s, 3H), 3.73 (q, J = 9 Hz, 1H), 3.45 (m, 1H), 2.64 (t, J = 8 Hz, 2H), 2.53 (q, J = 7 Hz, 2H), 2.38 (m, 1H), 2.28 (quintet, J = 6 Hz, 2H), 1.99 (m, 1H), 1.55 (hextet, J = 8 Hz, 2H), 1.15 (t, J = 7 Hz, 3H), 0.90 (t, J = 7 Hz, 3H); MS ES m/z = 593 (p +

CH3C00 ); IR (CHC13, cm ) 2963, 1719, 1589, 1461.
Anal. Calcd for C32H3807: C, 71.89; H, 7.16. Found: C, 71.41; H, 7.06.
o OH
/ ono ~ o COOMe O H
/ ono ~ I o ~
COONa C. Preparation of 2-(3-{3-[2-ethyl-5-hydroxy-4-(tetrahydrofuran-3-yl)phenoxy]-propoxy)-2-propylphenoxy)benzoic acid sodium salt hemihydrate.
A solution of 2-(3-{3-[2-ethyl-5-hydroxy-4-(tetrahydrofuran-3-yl)phenoxy]propoxy}-2-propylphenoxy)benzoic acid methyl ester (0.92 g, 1.7 mmol) in tetrahydrofuran (10 mL) and methanol (5 mL) was treated with 1 M aqueous lithium hydroxide solution (10 mL) at 55 °C for 2 h. The mixture was allowed to cool to room temperature and stirred for an additional 18 h. The mixture was concentrated in vacuo and the remaining aqueous mixture was washed once with diethyl ether. The aqueous layer was acidified with concentrated hydrochloric acid and the resulting solution extracted with ethyl acetate. The ethyl acetate layer was washed once with water, once with saturated sodium chloride solution, dried (sodium sulfate), filtered, and concentrated in vacuo. The resulting colorless oil was dissolved in diethyl ether and treated with 1 N aqueous sodium hydroxide solution (1.72 mL). The resulting biphasic mixture was diluted with chloroform and concentrated in vacuo. Diethyl ether was added and the mixture concentrated in vacuo. The resulting white foam was dried in vacuo at room temperature for 60 h to provide 0.78 g (84~) of the title compound: mp 67-71 °C.
1H 1VMR (DMSO-d6) 8 7.62 (dd, J = 8, 2 Hz, 1H), 7.30 (dt, J =
8, 2 Hz, 1H), 7.05 (m, 2H), 6.85 (s, 1H), 6.73 (d, J = 9 Hz, 1H), 6.70 (d, J = 9 Hz, 1H), 6.53 (s, 1H), 6.34 (d, J = 9 Hz, 1H), 4.15 (t, J = 6 Hz, 2H), 4.04 (t, J = 6 Hz, 2H), 3.95 (m, 1H), 3.88 (m, 1H), 3.75 (q, J = 9 Hz, 1H), 3.49 (m 2H), 2.60 (t, J = 8 Hz, 2H), 2.45 (q; J = 7 Hz, 2H), 2.15 (m, 3H), 1.90 (m, 1H), 1.48 (hextet, J = 8 Hz, 2H), 1.06 (t, J = 7 Hz, 3H), 0.83 (t, J = 7 Hz, 3H); MS ES m/z = 519 (p -+ -1 Na ); IR (CHC13, cm ) 2964, 1783, 1604, 1461.
Anal. Calcd for C31H35Na07 . 0.5 H20: C, 67.50; H, 6.58.
Found: C, 67.76; H, 6.68.
Example 16 Preparation of 2-~3-[3-(2-Ethyl-5-hydroxy-4-pyrrolidin-2-yl-phenoxy)propoxy]-2-propyl-phenoxy)benzoic acid hydrochloride hydrate.
O
Br ~ ~
~ O~O ~ I O
COOMe O O ~ O'~O
COOMe A. Preparation of 2-(2-benzyloxy-5-ethyl-4-{3-[3-(2-methoxycarbonylphenoxy)-2-propylphenoxy]propoxy~phenyl)pyrrole-1-carboxylic acid tert-butyl ester.
A mixture of 2-{3-[3-(5-benzyloxy-4-bromo-2-ethylphenoxy)propoxy]-2-propylphenoxy}-benzoic acid methyl ester (3.00 g, 4.73 mmol), N-boc pyrrole-2-boronic acid (1.99 g, 9.43 mmol), tetrakis(triphenylphosphine)palladium(0) (0.54 g, 0.47 mmol), and 2 M aqueous sodium carbonate solution (25 mL) in tetrahydrofuran (60 mL) was heated at reflux for 40 h. The mixture was cooled to room temperature, diluted with water, and extracted with ethyl acetate. The organic layer was separated, washed once with water, once with saturated sodium chloride solution, dried (sodium sulfate), filtered, and concentrated in vacuo. Chromatography (silica gel, 10~
ethyl acetate/90~ hexane) of the residue provided 2.6 g (76~) of the title compound as a solid. H NMR (CDC13) 8 7.88 (dd, J = 8, 2 Hz, 1H), 7.15-7.40 (m, 7H), 7.08 (m, 3H), 6.82 (d, J = 9 Hz, 1H), 6.68 (d, J = 9 Hz, 1H), 6.52 (s, 1H), 6.44 (d, J = 9 Hz, 1H), 6.23 (t, J = 4 Hz, 1H), 6.12 (m, 1H), 4.95 (s, 2H), 4.20 (t, J = 6 Hz, 2H); 4.15 (t, J =
6 Hz, 2H), 3.84 (s, 3H), 2.66 (t, J = 8 Hz, 2H), 2.60 (q, J
- 7 Hz, 2H), 2.30 (quintet, J = 6 Hz, 2H), 1.57 (hextet, J =
8 Hz, 2H), 1.28 (s, 9H), 1.18 (t, J = 7 Hz, 3H), 0.93 (t, J
- 7 Hz, 3H); TOS MS ES exact mass calculated for C44H53N2~8 (p + NH4 ): m/z = 737.3802. Found: 737.3804;

IR (CHC13, cm ) 2964, 1730, 1461.
Anal. Calcd for C44H49N08: C, 73.41; H, 6.86; N, 1.94.
Found: C, 73.76; H, 6.76; N, 2.04.

i i~ i~
0 0 ~ o'~o ~ o COOMe H
o O ~ O~O ~ O
COOMe B. Preparation of 2-(5-ethyl-2-hydroxy-4-~3-[3-(2-methoxycarbonylphenoxy)-2-propylphenoxy]propoxy)phenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester.
A solution of 2-(2-benzyloxy-5-ethyl-4-{3-[3-(2-methoxycarbonylphenoxy)-2-propylphenoxy]propoxy}phenyl)pyrrole-1-carboxylic acid tert-butyl ester (0.98 g, 1.4 mmol) in ethyl acetate (40 mL) was treated with 10o palladium-on-carbon (0.98 g) and hydrogenated at 45 psi and 45 °C for 25 h, at room temperature for 20 h, then at 45 °C for 19 h. The mixture TM
was cooled to room temperature, filtered through Celite , and the filtrate concentrated in vacuo to provide 0.76 g (88~) of the title compound as a colorless oil. H NMR
(CDC13) 7.87 (dd, J = 8, Hz, 1H), 7.37(dt, J 8, 2 8 2 = Hz, 1H), 7.10 (d, J Hz, 1H), 7.04 (d, J 9 1H), 6.91 = = Hz, (s, 1H), 6.81 (d, = 9 Hz, 1H), 6.67 (d, J Hz, 1H), J =

6.47 (s, 1H) 6.44 (d, J Hz, 1H) 5.09(m, 1H) 4.18 , = 9 , , (d, J 6 2H), 4.14 (t, J 6 2H), 3.8 4 3H), 3.45 = Hz, = Hz, (s, (m, 2H), 2.64 (t, = 8 Hz, 2H), 2.54 (m, 3H), 2.25 (m, 5H), J

2.06 (m, 1H), 1.54 (hextet, J = 8 Hz, 2H), 1.43 (s, 9H), 1.15 (t, J = 7 Hz, 3H), 0.90 (t, J = 7 Hz, 3H).
H
il i~
O O ~ O~O \ O \
COOMe H
O O ~ O~O \ O
COOLi C. Preparation of 2-(4-~3-[3-(2-carboxyphenoxy)-2-propylphenoxy]propoxy)-5-ethyl-2-hydroxyphenyl)pyrrolidine-1-carboxylic acid tart-butyl ester lithium salt hydrate.
A solution of 2-(5-ethyl-2-hydroxy-4-{3-[3-(2-methoxycarbonylphenoxy)-2-propylphenoxy]propoxy}phenyl)pyrrolidine-1-carboxylic acid tert-butyl ester (0.114 g, 0.18 mmol) in a 1:1 mixture of methanol/tetrahydrofuran (4 mL) was treated with solution of 1 M lithium hydroxide (4 mL) at room temperature for 18 h.
The mixture was concentrated in vacuo and the residue dissolved in water. The resulting mixture was extracted with ethyl acetate. The organic extract was dried (sodium sulfate), filtered, and concentrated in vacuo. The residue was diluted with diethyl ether, concentrated in vacuo, and dried to provide 90 mg (78~) of the title compound. MS ES

+ -1 m/z = 620 (p + 1 - Li ); IR (KBr, cm ) 2964, 1672, 1603, 1416.
Anal. Calcd for C36H44NO8Li . H20: C, 67.17; H, 7.20; N, 2.18. Found: C, 66.72; H, 6.99; N, 2.27.
H
O O ~ O~O ~ O
COOLi OH
i H
O~O ~ O \
COOH
D. Preparation of 2-(3-[3-(2-ethyl-5-hydroxy-4-pyrrolidin-2-yl-phenoxy)propoxy]-2-propylphenoxy~benzoic acid hydrochloride hydrate.
Into a solution of 2-(4-{3-[3-(2-carboxyphenoxy)-2-propylphenoxy]propoxy}-5-ethyl-2-hydroxyphenyl)pyrrolidine-1-carboxylic acid tert-butyl ester lithium salt hydrate (0.100 g, 0.16 mmol) in anhydrous diethyl ether (5 mL) was bubbled gaseous HC1. The resulting mixture was allowed to stir for 1 h. The mixture was concentrated in vacuo.
Chromatography (SCX cation exchange resin, 1:1 tetrahydrofuran/methanol to dilute ammonia/methanol) of the residue provided a tan solid. This material was dissolved in ether and treated with gaseous HC1. This mixture was concentrated in vacuo to provide 48 mg (52~) of the title compound. 1H NMR (DMSO-d6) 8 12.80 (bs, 1H), 10.12 (s, 1H), 9.34 (bs, 1H), 8.36 (bs, 1H), 7.79 (dd, J = 9, 2 Hz, 1H), 7.47 (dt, J = 8, 2 Hz, 1H), 7.17 (t, J = 8 Hz, 1H), 7.12 (d, J = 9 Hz, 1H), 7.07 (s, 1H), 6.80 (d, J = 9 Hz, 1H), 6.78 (d, J = 9 Hz, 1H), 6.58 (s, 1H), 6.35 (d, J = 9 Hz, 1H), 4.56 (m, 1H), 4.20 (t, J = 6 Hz, 2H); 4.11 (t, J = 6 Hz, 2H), 3.25 (m, 2H), 2.50 (m, 5H), 1.90-2.60 (m, 5H), 1.44 (hextet, J = 8 Hz, 2H), 1.08 (t, J = 7 Hz, 3H), 0.82 (t, J =
7 Hz, 3H); TOS MS ES exact mass calculated for C31H38N06 (p + 1): m/z = 520.2699. Found: 520.2672.
Example 17 Preparation of 2-~3-[3-(2-Ethyl-5-hydroxy-4-thiophen-3-yl-phenoxy)propoxy]-2-propyl-phenoxy)benzoic acid hydrate.
S
Br ~ I i ~ ~ o I i ~ O~CI I ~ O~CI
Known compound:
Sawyer et al., J. Med. Chem. 1995, 38, 4411.
A. Preparation of 3-[2-benzyloxy-4-(3-chloropropoxy)-5-ethylphenyl]thiophene. A mixture of 4-(benzyloxy)-5-bromo-2-(3-chloropropoxy)ethylbenzene (1.90 g, 5.30 mmol), 3-thiopheneboronic acid (2.00 g, 15.9 mmol), tetrakis(triphenylphosphine)palladium(0) (312 mg, 0.270 mmol), 2 M aqueous sodium carbonate solution (4 mL), and n-propanol (4 mL) in toluene (16 mL) was refluxed for 4 h.
The mixture was cooled to room temperature, diluted with diethyl ether, washed once with water and once with saturated sodium chloride solution. The organic layer was dried (magnesium sulfate), filtered, and concentrated in vacuo. Chromatography (silica gel, 5o ethyl acetate/95~
hexane) of the residue provided 1.54 g (80~) of the title product as a white solid: mp 65-67 °C. H NMR (CDC13) 8 7.58 (d, J = 2.8 Hz, 1H), 7.49 (d, J = 5.2 Hz, 1H), 7.45 7.30 (m, 7H), 6.62 (s, 1H), 5.13 (s, 2H), 4.14 (t, J = 5.8 Hz, 2H), 3.81 (t, J = 6.3 Hz, 2H), 2.66 (q, J = 7.5 Hz, 2H), 2.29 (quintet, J = 6.0 Hz, 2H), 1.24 (t, J = 7.5 Hz, 3H); MS

FD m/e 386 (p); IR (CHC13, cm ) 2969, 1613, 1501, 1138.
Anal. Calcd for C22H23~2C1S: C, 68.29; H, 5.99. Found: C, 68.53; H, 6.00.
\I \ I ~
I Ho ~ o O~CI CN
Known compound:
Sawyer et al., J. Med. Chem. 1995, 38, 4411.
\ I o I
I I I
O
CN
B. Preparation of 2-[2-propyl-3-[3-[5-(benzyloxy)-2-ethyl-4-(thiophen-3-yl)phenoxy]propoxy]phenoxy]benzonitrile.
A mixture of 4-(benzyloxy)-2-(3-chloropropoxy)-5-(thiophen-3-yl)ethylbenzene (1.25 g, 3.23 mmol), 3-(2-cyanophenoxy)-2-propylphenol (0.82 g, 3.2 mmol), potassium iodide (0.21 g, 1.3 mmol), potassium carbonate (1.12 g, 8.08 mmol), and methyl sulfoxide (2 mL) in 2-butanone (10 mL) was refluxed for 60 h. The mixture was cooled to room temperature, diluted with ether, and washed with water. The organic layer was dried (magnesium sulfate), filtered, and concentrated in vacuo. Chromatography (silica gel, 5o ethyl acetate/95o hexane) of the residue provided 1.31 g (670) of product as a colorless oil. H NMR (CDC13) 8 7.66 the title 1 (d, J = 7.8 Hz, 1H), 7.57 (d, J = 2.9 Hz, 1H), 7.48 (d, J =
5.2 Hz, 1H), 7.45-7.25 (m, 8H), 7.20 (t, J = 8.2 Hz, 1H), 7.10 (t, J = 8.1 Hz, 1H), 6.82 (d, J = 8.3 Hz, 1H), 6.77 (d, J = 8.6 Hz, 1H), 6.64 (s, 1H), 6.63 (d, J = 6.4 Hz, 1H), 5.11 (s, 2H), 4.26 (t, J = 6.0 Hz, 2H), 4.22 (t, J = 6.0 Hz, 2H), 2.65 (m, 4H), 2.36 (quintet, J = 5.9 Hz, 2H), 1.58 (hextet, J = 7.5 Hz, 2H), 1.24 (t, J = 7.5 Hz, 3H), 0.95 (t, J = 7.3 Hz, 3H); MS FD m/e 603 (p); IR (CHC13, cm ) 2967, 2250, 1613, 1501. Anal. Calcd for C38H37N04S: C, 75.59; H, 6.18; N, 2.32. Found: C, 74.65; H, 6.21; N, 2.57.

C. Preparation of 2-[2-propyl-3-[3-[2-ethyl-5-hydroxy-4-(thiophen-3-yl)phenoxy]propoxy]phenoxy]benzonitrile.
o I
o'~o ~ o CN
OH
\ ( \ ~ I ~
o'~o ~ o CN
To a solution of 2-[2-propyl-3-[3-[5-(benzyloxy)-2-ethyl-4-(thiophen-3-yl)phenoxy]propoxy]phenoxy]benzonitrile (900 mg, 1.49 mmol) in methylene chloride (25 mL) cooled to -78 °C
was added 1 M boron tribromide solution in methylene chloride (2.99 mL, 2.99 mmol) over 2 min. The resulting deep violet solution was stirred for 30 min and allowed to warm to room temperature. The mixture was diluted with water and shaken. The organic layer was separated, dried (magnesium sulfate), filtered, and concentrated in vacuo.
Chromatography (silica gel, 25o ethyl acetate, 75% hexane) provided 400 mg (52~) of the title product as a colorless oil. 1H NMR (CDC13) 8 7.84 (d, J = 4.8 Hz, 1H), 7.71 (d, J =
4.9 Hz, 1H), 7.66 (d, J = 7.7 Hz, 1H), 7.62 (s, 1H), 7.42 (t, J = 7.1 Hz, 1H), 7.27 (t, J = 6.6 Hz, 1H), 7.20 (s, 1H), 7.08 (t, J = 6.9 Hz, 1H), 6.85 (s, 1H), 6.89 (d, J = 8.1 Hz, 1H), 6.74 (d, J = 8.5 Hz, 1H), 6.60 (d, J = 7.6 Hz, 1H), 4.71 (s, 1H, -OH), 4.26 (t, J = 6.0 Hz, 4H), 2.72 (q, J =
7.4 dHz, 2H), 2.59 (t, J = 7.3 Hz, 2H), 2.39 (quintet, J =

6.1 Hz, 2H), 1.54 (hextet, J = 7.7 Hz, 2H), 1.25 (t, J = 7.5 Hz, 3H), 0.91 (t, J = 7.4 Hz, 3H).
D. Preparation of 2-[2-propyl-3-[3-[2-ethyl-5-hydroxy-4-(thiophen-3-yl)phenoxy]propoxy]phenoxy]benzoic acid hydrate.
OH
i I i O~O \ O
CN
OH
O~O ~ O
COOH
A solution of 2-[2-propyl-3-[3-[2-ethyl-5-hydroxy-4-(thiophen-3-yl)phenoxy]propoxy]phenoxy]benzonitrile (400 mg, 0.780 mmol) in 2:1 methanol/water (6 mL) was treated with 12.5 M aqueous sodium hydroxide (4.0 mL) at reflux for 36 h.
The mixture was cooled to room temperature, diluted with water, and extracted once with diethyl ether. The aqueous layer was acidified with concentrated hydrochloric acid and extracted twice with methylene chloride. The combined methylene chloride layers were dried (magnesium sulfate), filtered, and concentrated in vacuo to provide a tan solid:

mp 90-95 °C (dec). H NMR (CDC13) 8 8.24 (d, J = 7.8 Hz, 1H), 7.47 (d, J = 5.0 Hz, 1H), 7.44 (t, J = 8.6 Hz, 1H), 7.36 (d, J = 3 Hz, 1H), 7.24 (d, J = 4.9 Hz, 1H), 7.19 (m, 2H), 7.09 (s, 1H), 6.84 (d, J = 8.0 Hz, 1H), 6.73 (d, J =
8.3 Hz, 1H), 6.64 (d, J = 8.0 Hz, 1H), 6.55 (s, 1H), 5.38 (bs, 1H, -OH), 4.26 (t, J = 6.2 Hz, 2H), 4.21 (t, J = 7.1 Hz, 2H), 2.60 (m, 4H), 2.36 (quintet, J = 5.8 Hz, 2H), 1.51 (hextet, J = 7.1 Hz, 2H), 1.19 (t, J = 7.5 Hz, 3H), 0.90 (t, J = 7.4 Hz, 3H); MS FD m/e 532 (p); IR (KBr, cm ) 3200 (br), 2961, 1697, 1457, 1110. Anal. Calcd for C31H3206S ' H20: C, 67.62; H, 6.22. Found:. C, 67.34; H, 5.87.
The previously described LTB4 antagonists and anti-cangel agents used in the composition and method of the invention are often advantageously used in the form of salt derivatives which are an additional aspect of the invention.
ln~hen compounds of the invention possess an Acidic Groups) or other reactive group, salts may be formed which are more water soluble and/or physiologically suitable than the parent compound in its acid form. Representative pharmaceutically acceptable salts, include but are not limited to, the alkali and alkaline earth salts such as lithium, sodium, potassium, calcium, magnesium, aluminum and the like. Sodium salts are particularly preferred. Salts are conveniently prepared from the free acid by treating the acid form in solution with a base or by exposing the acid to an ion exchange resin. For example, the (Acidic Group) of the Z of Formula (I) may be selected as -C02H and salts may be formed by reaction with appropriate bases (e. g., NaOH, KOH) to yield the corresponding sodium or potassium salt.
Included within the definition of pharmaceutically acceptable salts are the relatively non-toxic, inorganic and organic base addition salts of compounds of the present invention, for example, ammonium, quaternary ammonium, and amine cations, derived from nitrogenous bases of sufficient basicity to form salts with the LTB4 antagonist compounds of this invention (see, for example, S. M. Berge, et al., "Pharmaceutical Salts," J. Phar. Sci., 66: 1-19 (1977)).
Certain compounds of the invention may possess one or more chiral centers and may thus exist in optically active forms.
All such stereoisomers as well as the mixtures thereof are intended to be included in the invention. If a particular stereoisomer is desired, it can be prepared by methods well known in the art, for example, by using stereospecific reactions with starting materials which contain the asymmetric centers and are already resolved or, alternatively, by methods which lead to mixtures of the stereoisomers and subsequent resolution by known methods.
For example, a racemic mixture may be reacted with a single enantiomer of some other compound. This changes the racemic form into a mixture of diastereomers. Then, because the diastereomers have different melting points, different boiling points, and different solubilities, they can be separated by conventional means, such as crystallization.
Prodrugs are derivatives of the LTB4 antogonist and anti-cancer compounds used in the invention which have chemically or metabolically cleavable groups and become by solvolysis or under physiological conditions the compounds of the invention which are pharmaceutically active in vivo.
Derivatives of the compounds of this invention have activity in both their acid and base derivative forms, but the acid derivative form often offers advantages of solubility, tissue compatibility, or delayed release in a mammalian organism (see, Bundgard, H., Design of Prodrugs, pp. 7-9, 21-24, Elsevier, Amsterdam 1985). Prodrugs include acid derivatives well known to practitioners of the art, such as, for example, esters prepared by reaction of the parent acidic compound with a suitable alcohol, or amides prepared by reaction of the parent acid compound with a suitable amine. Simple aliphatic or aromatic esters derived from acidic groups pendent on the compounds of this invention are preferred prodrugs. In some cases it is desirable to prepare double ester type prodrugs such as (acyloxy) alkyl esters or ((alkoxycarbonyl)oxy)alkyl esters. Particularly preferred esters as prodrugs are methyl, ethyl, propyl, isopropyl, n-butyl, isobutyl, tert-butyl, morpholinoethyl, and N,N-diethylglycolamido.
Esters of carboxylic acids are preferred prodrugs of the compounds of the composition of the invention.
Methyl ester prodrugs may be prepared by reaction of the acid form of a compound of formula (I) in a medium such as methanol with an acid or base esterification catalyst (e.g., NaOH, H2S04). Ethyl ester prodrugs are prepared in similar fashion using ethanol in place of methanol.
N,N-diethylglycolamido ester prodrugs may be prepared by reaction of the sodium salt of a compound of Formula (I) (in a medium such as dimethylformamide) with 2-chloro-N,N-diethylacetamide (available from Aldrich Chemical Co., Milwaukee, Wisconsin USA; Item No. 25,099-6).
Morpholinylethyl ester prodrugs may be prepared by reaction of the sodium salt of a compound of Formula (I) (in a medium such as dimethylformamide) 4-(2-chloroethyl)morpholine hydrochloride (available from Aldrich Chemical Co., Milwaukee, Wisconsin USA, Item No. C4,220-3).
Preferred LTBg compounds and anti-cancer compounds of the compositions of the wherein the acid, salt and prodrug derivatives thereof are respectively selected from:
carboxylic acid, sodium salt, and ester prodrug.
The compositions of the present invention are a combination of therapeutically effective amounts of the leukotriene (LTB4) antagonists, noted above, and a therapeutically effective amount of the anti-cancer agents noted above. The composition may be formulated with common excipients, diluents or carriers, and compressed into tablets, or formulated elixirs or solutions for convenient oral administration or administered by intramuscular intravenous routes. The compounds can be administered transdermally and maybe formulated as sustained relief dosage forms and the like.
In another embodiment, the invention relates to a method of treating a patient suffering from a non-multi drug resistant cancerous condition which comprises the separate administration of a therapeutically effective amount of the leukotriene (LTB4) antagonists, and the anti-cancer agent.
V~hen administered separately, the leukotriene (LTBg) antagonists, and the anti-cancer agent may be administered on a different schedule. One may be administered before the other as long as the time between the two administrations falls within a therapeutically effective interval.
Therapeutically effective interval is a period of time beginning when one of either (a) the leukotriene (LTB4) antagonist or (b) the anti-cancer agent is administered to a human and ending at the limit of the beneficial effect in the treatment of cancer of the combination of (a) and (b).
The methods of administration of the leukotriene LTB4 antagonist and the anti-cancer agent may vary. Thus, one agent may be administered orally, while the other is administered intravenously. It is possible that one of the products may be administered as a continuous infusion while the other is provided in discreet dosage forms. It is particularly important that the anti-cancer drug be given in the manner known to optimize its performance.

Pharmaceutical Compositions of the Invention Preferably compounds of the invention or pharmaceutical formulations containing these compounds are in unit dosage form for administration to a mammal. The unit dosage form can be a capsule, an IV bag, a tablet, or a vial. The quantity of Active Ingredient in a unit dose of composition is a therapeutically effective amount and may be varied according to the particular treatment involved. It may be appreciated that it may be necessary to make routine variations to the dosage depending on the age and condition of the patient. The dosage will also depend on the route of administration.
The compound can be administered by a variety of routes including oral, aerosol, rectal, transdermal, subcutaneous, intravenous, intramuscular, and intranasal.
Pharmaceutical formulations of the invention are prepared by combining (e. g., mixing) a therapeutically effective amount of the anti-cancer agent (e. g., a 2',2'-difluoronucleoside and an LTBg antagonist, such as the compound of Formula A, Formula I, II) together with a pharmaceutically acceptable carrier or diluent therefor.
The present pharmaceutical formulations are prepared by known procedures using well known and readily available ingredients.
In making the compositions of the present invention, the Active Ingredient will usually be admixed with a carrier, or diluted by a carrier, or enclosed within a carrier which may be in the form of a capsule, sachet, paper or other container. When the carrier serves as a diluent, it may be a solid, lyophilzed solid or paste, semi-solid, or liquid material which acts as a vehicle, or can be in the form of tablets, pills, powders, lozenges, elixirs, suspensions, emulsions, solutions, syrups, injectable liquids, aerosols (as a solid or in a liquid medium), or ointment, containing, for example, up to 10~
by weight of the active compound. The compounds of the present invention are preferably formulated prior to administration.
For the pharmaceutical formulations any suitable carrier known in the art can be used. In such a formulation, the carrier may be a solid, liquid, or mixture of a solid and a liquid. For example, for intravenous injection the compounds of the invention may be dissolved in sterile water, sterile saline, or sterile water or saline containing sugars and/or buffers at a concentration of about 0.05 to about 5.0 mg/ml in a 4~ dextrose/0.5~ Na citrate aqueous solution.
Solid form formulations include powders, tablets and capsules. A solid carrier can be one or more substances which may also act as flavoring agents, lubricants, solubilisers, suspending agents, binders, tablet disintegrating agents and encapsulating material.
Tablets for oral administration may contain suitable excipients such as calcium carbonate, sodium carbonate, lactose, calcium phosphate, together with disintegrating agents, such as maize, starch, or alginic acid, and/or binding agents, for example, gelatin or acacia, and lubricating agents such as magnesium stearate, stearic acid, or talc.
In powders the carrier is a finely divided solid which is in admixture with the finely divided Active Ingredient.
In tablets the Active Ingredient is mixed with a carrier having the necessary binding properties in suitable proportions and compacted in the shape and size desired.
Advantageously, compositions containing the compound of Formula (I) may be provided in dosage unit form, preferably each dosage unit containing from about 5 to about 500 mg (from about 5 to 50 mg in the case of parenteral or inhalation administration, and from about 25 to 500 mg in the case of oral or rectal administration. 0.5 to 20 mg/kg, of Active Ingredient may be administered although it will, of course, readily be understood that Dosages from about 0.5 to about 300 mg/kg per day, preferably the amount of the compound or compounds of Formula I actually to be administered will be determined by a physician, in the light of all the relevant circumstances.
Powders and tablets preferably contain from about 1 to about 99 weight percent of the Active Ingredient which is the novel compound of this invention. Suitable solid carriers are magnesium carbonate, magnesium stearate, talc, sugar lactose, pectin, dextrin, starch, gelatin, tragacanth, methyl cellulose, sodium carboxymethyl cellulose, low melting waxes, and cocoa butter.

Sterile liquid form formulations include suspensions, emulsions, syrups and elixirs.
The Active Ingredient can be dissolved or suspended in a pharmaceutically acceptable carrier, such as sterile water, sterile organic solvent or a mixture of both. By "pharmaceutically acceptable" it is meant the carrier, diluent or excipient must be compatible with the other ingredients of the formulation and not deleterious to the recipient thereof.
The Active Ingredient can also be dissolved in a suitable organic solvent, for instance aqueous propylene glycol. Other compositions can be made by dispersing the finely divided Active Ingredient in aqueous starch or sodium carboxymethyl cellulose solution or in a suitable oil.
The following pharmaceutical formulations 1 to 22 are illustrative only and are not intended to limit the scope of the invention in any way. "Active Ingredient", refers to a 2',2'-difluoronucleoside or a compound according to Formula A, Formula (I) or (II) or a pharmaceutically acceptable salt, solvate, or prodrug thereof.
In one embodiment the compositions of the present invention are a combination of therapeutically effective amounts of the leukotriene (LTBg) antagonists, noted above, and a therapeutically effective amount of a 2',2'-difluoronucleoside anti-cancer agent. The composition may be formulated with common excipients, diluents or carriers, and compressed into tablets, or formulated elixirs or solutions for convenient oral administration or administered by intramuscular intravenous routes. The compounds can be administered transdermally and maybe formulated as sustained relief dosage forms and the like.
In another embodiment, the 2',2'-difluoronucleoside anti-cancer agents are formulated independently of the leukotrienes (LTB4) antagonists and are administered separately. The anti-cancer agents may be formulated with common excipients, diluents or carriers and administered by intravenous infusion. On the other hand, the anti-cancer agents may be formulated into liquids suitable for oral administration. Anti-cancer agents may also be compressed into tablets and administered orally. If the anti-cancer agents and the leukotrienes (LTBg) antagonists are administered separately, the anti-cancer agents may be administered before, after or during the administration of the leukotriene (LTB4) antagonists. If the anti-cancer agents are administered separately from the leukotrienes (LTBg) antagonists, they must be administered within a therapeutically effective interval.
The method of treating a human patient according to the present invention includes both the administration of the combination of leukotriene (LTB4) antagonists and an anti-cancer agent as well as the separate administration of the leukotriene (LTB4) antagonists and the anti-cancer agent.
When administered separately, the leukotriene (LTBg) antagonists are formulated into formulations which may be administered by the oral and rectal routes, topically, parenterally, e.g., by injection and by continuous or discontinuous intra-arterial infusion, in the form of, for example, tablets, lozenges, sublingual tablets, sachets, cachets, elixirs, gels, suspensions, aerosols, ointments, for example, containing from 1 to 10~ by weight of the active compound in a suitable base, soft and hard gelatin capsules, suppositories, injectable solutions and suspensions in physiologically acceptable media, and sterile packaged powders adsorbed onto a support material for making injectable solutions. Advantageously for this purpose, compositions may be provided in dosage unit form, preferably each dosage unit containing from about 5 to about 500 mg (from about 5 to 50 mg in the case of parenteral or inhalation administration, and from about 25 to 500 mg in the case of oral or rectal administration) of a compound of Formula I or Formula II. Dosages from about 0.5 to about 300 mg/kg per day, preferably 0.5 to 20 mg/kg, of active ingredient may be administered although it will, of course, readily be understood that the amount of the compound or compounds of Formula I actually to be administered will be determined by a physician, in the light of all the relevant circumstances including the condition to be treated, the choice of compound to be administered and the choice of route of administration and therefore the above preferred dosage range is not intended to limit the scope of the present invention in any way.
The formulations useful for separate administration of the leukotriene (LTBg) antagonists will normally consist of at least one compound selected from the compounds of Formula A and Formula I mixed with a carrier, or diluted by a carrier, or enclosed or encapsulated by an ingestible carrier in the form of a capsule, sachet, cachet, paper or other container or by a disposable container such as an ampoule. A carrier or diluent may be a solid, semi-solid or liquid material which serves as a vehicle, excipient or medium for the active therapeutic substance. Some examples of the diluents or carrier which may be employed in the pharmaceutical compositions of the present invention are lactose, dextrose, sucrose, sorbitol, mannitol, propylene glycol, liquid paraffin, white soft paraffin, kaolin, fumed silicon dioxide, microcrystalline cellulose, calcium silicate, silica, polyvinylpyrrolidone, cetostearyl alcohol, starch, modified starches, gum acacia, calcium phosphate, cocoa butter, ethoxylated esters, oil of theobroma, arachis oil, alginates, tragacanth, gelatin, syrup, methyl cellulose, polyoxyethylene sorbitan monolaurate, ethyl lactate, methyl and propyl hydroxybenzoate, sorbitan trioleate, sorbitan sesquioleate and oleyl alcohol and propellants such as trichloromonofluoromethane, dichlorodifluoromethane and dichlorotetrafluoroethane. In the case of tablets, a lubricant may be incorporated to prevent sticking and binding of the powdered ingredients in the dies and on the punch of the tableting machine. For such purpose there may be employed for instance aluminum, magnesium or calcium stearates, talc or mineral oil.
Preferred pharmaceutical forms of the present invention are capsules, tablets, suppositories, injectable solutions, creams and ointments. Especially preferred are formulations for inhalation application, such as an aerosol, and for oral ingestion.
The following formulation examples may employ as active compounds any of the leukotriene (LTB4) antagonists noted above. The examples are illustrative only and are not intended to limit the scope of the invention in any way.

Hard gelatin capsules are prepared using the following ingredients:
Quantity (mg/capsule) 3-(2-(3-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)-6-(4-carboxy-phenoxy)phenyl)propanoic acid 250 Starch 200 Magnesium stearate 10 The above ingredients are mixed and filled into hard gelatin capsules in 460 mg quantities.

A tablet is prepared using the ingredients below:
Quantity (mg/capsule) 1-(4-(Carboxymethoxy)phenyl)-1-(1H-tetrazol-5-yl)-6-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)hexane 250 Cellulose, microcrystalline 400 Silicon dioxide, fumed 10 Magnesium stearate 5 The components are blended and compressed to form tablets each weighing 665 mg.

An aerosol solution is prepared containing the following components:
Weight o 3-[4-[7-Carboxy-9-oxo-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]-9H-xanthene]]propanoic acid 0.25 Ethanol 30.00 Propellant 11 10.25 (trichlorofluoromethane) Propellant 12 29.75 (Dichlorodifluoromethane) Propellant 114 29.75 (Dichlorotetrafluoroethane) The active compound is dissolved in the ethanol and the solution is added to the propellant 11, cooled to -30°C. and transferred to a filling device. The required amount is then fed to a container and further filled with the pre-mixed propellants 12 and 114 by means of the cold-filled method or pressure-filled method. The valve units are then fitted to the container.

Tablets each containing 60 mg of active ingredient are made up as follows:
2-[2-Propyl-3-[3-[2-ethyl-5-hydroxy-4-(4-fluorophenyl)phenoxy]propoxy]phenoxy]-benzoic acid sodium salt 60 mg Starch 45 mg Microcrystalline cellulose 35 mg Polyvinylpyrrolidone 4 mg (as 10~ solution in water) Sodium carboxymethyl starch 4.5 mg Magnesium stearate 0.5 mg Talc 1 mg Total 150 mg The active ingredient, starch and cellulose are passed through a No. 45 mesh U.S. sieve (355 ~,m) and mixed thoroughly. The solution of polyvinylpyrrolidone is mixed with the resultant powders which are then passed through a No. 14 mesh U.S. sieve (1.4 mm). The granules so produced are dried at 50-60° and passed through a No. 18 mesh U.S.
sieve (1.00 mm). The sodium carboxymethyl starch, magnesium stearate and talc, previously passed through a No. 60 mesh U.S. sieve (250 Vim), are then added to the granules which, after mixing, are compressed on a tablet machine to yield tablets each weighing 150 mg.

Capsules each containing 80 mg of medicament are made as follows:
5-[3-[2-(1-Carboxy)ethyl]-4-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]-phenyl]-4-pentynoic acid 80 mg Starch 59 mg Microcrystalline cellulose 59 mg Magnesium stearate 2 mg Total 200 mg The active ingredient, cellulose, starch and magnesium stearate are blended, passed through a No. 45 mesh U.S.
sieve (355 Vim), and filled into hard gelatin capsules in 200 mg quantities.

Suppositories each containing 225 mg of active ingredient are made as follows:
3-(5-(6-(4-(4-Fluorophenyl)-5-hydroxy-2-ethylphenoxy)propoxy)-2-carboxymethyl-1,2,3,4-tetrahydronaphthalen-1(2H)-one)propanoic acid 225 mg Unsaturated or saturated fatty acid glycerides to 2,000 mg The active ingredient is passed through a No. 60 mesh U.S. sieve (250 Vim) and suspended in the fatty acid glycerides previously melted using the minimum heat necessary. The mixture is then poured into a suppository mold of nominal 2 g capacity and allowed to cool.

Suspensions each containing 50 mg of medicament per 5 mL dose are made as follows:
2-[2-Propyl-3-[3-[2-ethyl-4-(4-fluorophenyl) 5-hydroxyphenoxy]propoxy]phenoxy]benzoic acid 50 mg Sodium carboxymethyl cellulose 50 mg Sugar 1 g Methyl paraben 0.05 mg Propyl paraben 0.03 mg Flavor q.v.
Color q.v.
Purified water to 5 mL
The medicament is passed through a No. 45 mesh U.S.
sieve (355 ~,m) and mixed with the sodium carboxymethylcellulose, sugar, and a portion of the water to form a suspension. The parabens, flavor and color are dissolved and diluted with some of the water and added, with stirring. Sufficient water is then added to produce the required volume.

Hard gelatin capsules are prepared using the following ingredients:
Quantity (mg/capsule) 1-(4-amino-5-methyl-2-oxo-1H-pyrimidin-1-yl)-2-desoxy- 250 2',2'-difluororibose Starch dried 200 Magnesium stearate 10 The above ingredients are mixed and filled into hard gelatin capsules in 460 mg quantities.

A tablet formula is prepared using the ingredients below:
Quantity (mg/tablet) 1-(2-oxo-4-amino-1H-pyrimidin-1-yl)-2-desoxy-2',2'-difluoro- 250 ribose Cellulose, microcrystalline Silicon dioxide, fumed 15 Stearic acid 5 The components are blended and compressed to form tablets each weighing 665 mg.

An aerosol solution is prepared containing the following components:
Weight . o 1-(2,4-dioxo-1H,3H-pyrimidin-1-yl)-2-desoxy-2',2'-difluoro-ribose 0.25 Ethanol 29.75 Propellant 22 70.00 (Chlorodifluoromethane) The active compound is mixed with ethanol and the mixture added to a portion of the propellant 22, cooled to -30° C. and transferred to a filling device. The required amount is then placed in a stainless steel container and diluted with the remainder of the propellant.
The valve units are then fitted to the container.

Tablets each containing 60 mg of active ingredient are made up as follows:
1-(4-amino-2-oxo-1H-pyrimidin-1-yl)-2-desoxy-2',2'-difluoro-ribose 60 mg Starch 45 mg Microcrystalline cellulose 35 mg Polyvinylpyrrolidone 4 mg (as 10o solution in water) Sodium carboxymethyl starch 4.5 mg Magnesium stearate 0.5 mg Talc 1 mg The difluoronucleoside starch and cellulose are passed through a No. 45 mesh U.S. sieve and mixed thoroughly. The solution of polyvinylpyrrolidone is mixed with the resultant powders which are then passed through a No. 14 mesh U.S.
sieve. The granules so produced are dried at 50°-60° C. and passed through a No. 18 mesh U.S. sieve.
The sodium carboxymethyl starch, magnesium stearate and talc, previously passed through a No. 60 mesh U.S. sieve, are then added to the granules which, after mixing, are compressed on a tablet machine to yield tablets each weighing 150 mg.

Capsules each containing 80 mg of medicament are made as follows:
1-(4-amino-2-oxo-1H-pyrimidin-1-yl)-2-desoxy-2',2'-difluor-oxylose 80 mg Starch 59 mg Microcrystalline cellulose 59 mg Magnesium stearate 2 mg The active ingredient, cellulose, starch and magnesium stearate are blended, passed through a No. 45 mesh U.S.
sieve, and filled into hard gelatin capsules in 200 mg quantities.

Suppositories each containing 225 mg of nucleoside are made as follows:
1-(2,4-dioxo-1H,3H-pyrimidin-1-yl)-2-desoxy-2',2'-difluoro-ribose 225 mg Saturated fatty acid 2 g glycerides to The nucleoside is passed through a No. 60 mesh U.S. sieve and suspended in the saturated fatty acid glycerides previously melted using the minimum heat necessary. The mixture is then poured into a suppository mold of nominal 2 g capacity and allowed to cool.

Suspensions each containing 50 mg of medicament per 5 ml dose are made as follows:
1-(4-amino-5-methyl-2-oxo-1H-pyrimidin-1-yl)-2-desoxy-2',2'-difluororibose 50 mg Sodium carboxymethyl Cellulose 50 mg Syrup 1.25 ml Benzoic acid solution 0.10 ml Flavor q.v.
Color q.v.
Purified water to 5, ml An intravenous formulation is prepared as follows:
1-(4-amino-2-oxo-1H-pyrimidin 1-yl)-2-desoxy-2',2'-difluoro ribose 100 mg isotonic saline 1000 ml The solution of the above ingredients is administered intravenously at a rate of 1 ml/minute to a mammal in need of treatment from susceptible neoplasms.

Hard gelatin capsules are prepared using the following ingredients:
Quantity (mg/capsule) 3-(2-(3-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)-6-(4-carboxy-phenoxy)phenyl)propanoic acid 2',2'-Diflouro-2'-deoxycytidine monohydrochloride Starch 200 Magnesium stearate 10 The above ingredients are mixed and filled into hard gelatin capsules in 710mg quantities.

A tablet is prepared using the ingredients below:
Quantity (mg/capsule) 1-(4-(Carboxymethoxy)phenyl)-1-(1H-tetrazol-5-yl)-6-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)hexane 2',2'-Difluoro-2'-deoxycytidine monochloride 250 Cellulose, microcrystalline 400 Silicon dioxide, fumed 10 Magnesium stearate 5 The components are blended and compressed to form tablets each weighing 915 mg.

An aerosol solution is prepared containing the following components:
Weight 3-[4-[7-Carboxy-9-oxo-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]-9H-xanthene]]propanoic acid 0.25 2',2'-difluoro-2'-deoxycytidine monohydrochloride 0.25 Ethanol 30.00 Propellant 11 10.00 (trichlorofluoromethane) Propellant 12 29.75 (Dichlorodifluoromethane) Propellant 114 29.75 (Dichlorotetrafluoroethane) The active compound is dissolved in the ethanol and the solution is added to the propellant 11, cooled to -30°C. and transferred to a filling device. The required amount is then fed to a container and further filled with the pre-mixed propellants 12 and 114 by means of the cold-filled method or pressure-filled method. The valve units are then fitted to the container.

Tablets each containing 60 mg of active ingredient are made up as follows:
2-[2-Propyl-3-[3-[2-ethyl-5-hydroxy-4-(4-fluorophenyl)phenoxy]propoxy]phenoxy]-benzoic acid sodium salt 60 mg 2',2'-difluoro-2'deoxycytidine monohydrochloride 60 mg Starch 45 mg Microcrystalline cellulose 35 mg Polyvinylpyrrolidone 4 mg (as 10~ solution in water) Sodium carboxymethyl starch 4.5 mg Magnesium stearate 0.5 mg Talc 1 mg Total 210 mg The active ingredient, starch and cellulose are passed through a No. 45 mesh U.S. sieve (355 Vim) and mixed thoroughly. The solution of polyvinylpyrrolidone is mixed with the resultant powders which are then passed through a No. 14 mesh U.S. sieve (1.4 mm). The granules so produced are dried at 50-60° and passed through a No. 18 mesh U.S.
sieve (1.00 mm). The sodium carboxymethyl starch, magnesium stearate and talc, previously passed through a No. 60 mesh U.S. sieve (250 ~.m), are then added to the granules which, after mixing, are compressed on a tablet machine to yield tablets each weighing 210 mg.

Capsules each containing 80 mg of medicament are made as follows:
5-[3-[2-(1-Carboxy)ethyl]-4-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]-phenyl]-4-pentynoic acid 80 mg 2',2'-difluoro-2'deoxycytidine monohydrochloride 80 mg Starch 59 mg Microcrystalline cellulose 59 mg Magnesium stearate 2 mg Total 280 mg The active ingredient, cellulose, starch and magnesium stearate are blended, passed through a No. 45 mesh U.S.
sieve (355 ~,m), and filled into hard gelatin capsules in 280 mg quantities.

Suppositories each containing 225 mg of active ingredient are made as follows:
3-(5-(6-(4-(4-Fluorophenyl)-5-hydroxy-2-ethylphenoxy)propoxy)-2-carboxymethyl-1,2,3,4-tetrahydronaphthalen-1(2H)-one)propanoic acid 225 mg 2',2'-difluoro-2'-deoxycytidine monochloride 225 mg Unsaturated or saturated fatty acid glycerides to 2,000 mg The active ingredient is passed through a No. 60 mesh U.S. sieve (250 Vim) and suspended in the fatty acid glycerides previously melted using the minimum heat necessary. The mixture is then poured into a suppository mold of nominal 2 g capacity and allowed to cool.

Suspensions each containing 50 mg of medicament per 5 mL dose are made as follows:
2-[2-Propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]phenoxy]benzoic acid 50 mg 2',2'-difluoro-2'-deoxycytidine monohydrochloride 50 mg Sodium carboxymethyl cellulose 50 mg Sugar 1 g Methyl paraben 0.05 mg Propyl paraben 0.03 mg Flavor q .v.

Color q .v.

Purified water to 5 mL

The medicament is passed through a No. 45 mesh U.S. sieve (355 E.tzn) and mixed with the sodium carboxymethylcellulose, sugar, and a portion of the water to form a suspension. The parabens, flavor and color are dissolved and diluted with some of the water and added, with stirring. Sufficient water is then added to produce the required volume.

Pharmaceutical Compositions of the Invention The pharmaceutical composition of the invention comprises as essential ingredients:
(a) an LTB4 antagonist, and (b) an anti-cancer agent.
When the pharmaceutical composition of the invention is prepared in injectable form it is a composition comprising as ingredients:
(a) an LTB4 antagonist, (b) an anti-cancer agent, and (c) an injectable liquid carrier.
Pharmaceutically acceptable carriers are those well known in the medical arts, such as sterile water, sterile water containing saline, and sterile water containing sugars and/or saline.
atio and Amount of Ingredients in the Composition of the Invention The essential ingredients (a) an LTB4 antagonist and (b) anti-cancer compound are present in the formulation in such proportion that a dose of the formulation provides a pharmaceutically effective amount of each ingredient to the patient being treated. Typically, the weight ratio of LTBg antagonist to anti-cancer agent 1:100 to 100 to 1, preferable from 10:1 to 1:10 and most preferable from 1:4 to 4:1.
The leukotriene (LTB4) antagonists are generally administered prior, during and after the 2',2'-difluoronucleoside anti-cancer agent is administered. If the leukotriene (LTB4) antagonists are administered after the 2',2'-difluoronucleoside anti-cancer agent they should be administered within a therapeutically effective interval.

The Nude Mouse Xenograft test used to evaluate anti-oncolytic agents of this invention is well known and generally described in the textbook; Beverly A Teicher, Editor, Anticancer Drug Development Guide, Humana Press, Totowa, New Jersey, 1997, p.75-124 (ISBN 0-89603-461-5); the disclosure of which is incorporated herein by reference.
The xenograft test is more particularly described as follows:
Male or female nude mice, selected as appropriate to the gender of the tumor (Charles River), were treated with total body gamma Radiation (450 rads). After 24 hours, human LNCaP and DU-145 prostate carcinomas, Panc-1 and BxPC-3 pancreatic carcinomas, and H460 and Calu-6 non-small cell lung carcinomas (all carcinomas available from American Type Culture Collection, Manassas, VA) prepared from a brie of donor tumors (5 x 106 cells) were implanted subcutaneously in a hind-leg of the mice. The mice were treated with 2-[2-propyl-3-[3-[2-ethyl-5-hydroxy-4-(4-fluorophenyl)phenoxy]propoxy]phenoxy] benzoic acid (Formula IV), at dosages of 30, 100, 200, or 300 mg per kilogram daily, administered orally, beginning 4 days after the tumor cell implantation. Gemcitabine (60 mg/kg) was administered intraperitoneally.
Tumor response was monitored by tumor volume measurement performed twice per week over the course of 60-90 days. Body weights were determined as a general measurement of toxicity. The mice were divided into an untreated control group and multiple treatment groups with five mice in each group.
The data was analyzed by determining the mean tumor volume for the control group and each treatment group over the course of the experiment and calculated the tumor growth delay as the difference in days for the treatment versus the control tumors to reach the volume of 1000 mm3.

Table 1 Mouse Xenograft Test Results Growth Delay of Prostate Tumor~l~
Treatment dose dose TGD TGD, sem Formula IV GEM

Formula IV 30 - 1.2 0.30 Formula IV 100 - 2.0 0.30 Formula IV 200 - 2.2 0.30 GEM - 60 12.2 0.50 Formula IV 30 60 43.2 3.00 + GEM

Formula IV 100 60 51.2 3.50 + GEM

(1) - LNCaP prostate carcinoma Formula IV = the LTB4 antagonist, 2-[2-propyl-3-[3-[2-ethyl-5-hydroxy-4-(4-fluorophenyl)phenoxy]propoxy]phenoxy]benzoic acid GEM = gemcitabine hydrochloride, a 2',2'-difloronucleoside anti-cancer agent, product of Eli Lilly and Company LNCaP = LNCaP Prostate Carcinoma dose = milligrams per kilogram mouse body weight TGD = average tumor growth delay in days sem = standard error of the mean Table 2 Mouse Xenograft Test Results Growth Delay of Prostate Tumor~2~
Treatment dose dose TGD TGD, sem Formula IV GEM

Formula IV 30 - 5.8 0.50 Formula IV 100 - 7.7 0.60 Formula IV 300 - 12.7 1.00 GEM - 60 9.6 0.80 Formula IV 30 60 15.6 1.40 + GEM

Formula IV 100 60 25.2 2.20 + GEM

(2) - DU-145 prostate carcinoma Table 3 Mouse Xenograft Test Results Growth Delay of Pancreatic Tumor~3~
Treatment dose dose TGD TGD, sem Formula IV GEM

Formula IV 30 - 7.4 0.50 Formula IV 100 - 21.6 2.00 Formula IV 300 - 30.2 3.20 GEM - 60 17.1 1.50 Formula IV 30 60 22.9 1.90 + GEM

Formula IV 100 60 27.0 2.30 + GEM

(3) - tumor is BxPC3 pancreatic cancer Table 4 Mouse Xenograft Test Results Growth Delay of Pancreatic Tumor~4~
Treatment dose dose TGD TGD, sem Formula IV GEM

Formula 30 - 10.2 1.40 IV

Formula 100 - 16.7 2.00 IV

Formula 200 - 19.4 2.40 IV

GEM - 60 7.70 0.80 Formula 30 60 18.2 1.50 IV
+ GEM

Formula 100 60 23.3 2.30 IV
+ GEM

Formula 200 60 29.1 3.00 IV
+ GEM

(4) - tumor is Panc-1 pancreatic cancer Table 5 Mouse Xenograft Test Results Growth Delay of non-Small cell Lung Tumor~s~
Treatment dose dose TGD TGD, sem Formula GEM
IV

Formula IV 30 - 10.9 1.00 Formula IV 100 - 13.2 1.20 Formula IV 200 - 13.9 1.30 GEM - 60 9.3 0.90 Formula IV 30 60 20.2 2.00 + GEM

Formula IV 100 60 21.3 2.20 + GEM

Formula IV 200 60 32.0 3.10 + GEM

(5) - non-Small cell Lung tumor is Human Table 6 Mouse Xenograft Test Results Growth Delay of non-Small cell Lung Tumor~6~
Treatment dose dose TGD TGD, sem Formula GEM
IV

Formula IV 30 - 7.4 0.60 Formula IV 100 - 10.0 0.80 Formula IV 200 - 17.9 1.60 GEM - 60 14.0 1.20 Formula IV 30 60 17.4 1.60 + GEM

Formula IV 100 60 22.5 2.00 + GEM

(6) - non-Small cell Lung tumor is Calu-6 carcinoma Detailed Description of the Drawings:
Figures 1 thru 6 in the Drawings display the data in the Tables 1 thru 6, supra. The Figures illustrate the increased effectiveness of a combination treatment of (i) Formula IV and (ii) gemcitabine hydrochloride in delaying tumor growth over use of the individual agents (i) or (ii).
Fig. 1 - displays various treatments for LNCaP prostate carcinoma.

Bars (1), (2), and (3) display tumor growth delay resulting from use of LTB4 inhibitor, Formula IV, alone at doses of 30, 100, and 200 mg/kg, respectively.
Bar (4) displays tumor growth delay for the anti-cancer agent, gemcitabine hydrochloride, alone at a dose of 60 mg/kg.
Bars (5) and (6) display tumor growth delay resulting from combined use of Formula IV (at doses of 30 and 100 mg/kg) and gemcitabine hydrochloride (at a dose of 60 mg/kg); respectively.
Fig. 2 - displays various treatments for DU-145 prostate carcinoma.
Bars (1), (2), and (3) display tumor growth delay resulting from use of LTB4 inhibitor, Formula IV, alone at doses of 30, 100, and 300 mg/kg, respectively.
Bar (4) display tumor growth delay for the anti-cancer agent, gemcitabine hydrochloride, alone at a dose of 60 mg/kg.
Bars (5) and (6) display tumor growth delay resulting from combined use of Formula IV (at doses of 30 and 100 mg/kg) and gemcitabine hydrochloride (at a dose of 60 mg/kg); respectively.
Fig. 3 - displays various treatments for BxPC3 pancreatic carcinoma.
Bars (1), (2), and (3) display tumor growth delay resulting from use of LTB4 inhibitor, Formula IV, alone at doses of 30, 100, and 300 mg/kg, respectively.
Bar (4) display tumor growth delay for the anti-cancer agent, gemcitabine hydrochloride, alone at a dose of 60 mg/kg.

Bars (5) and (6) display tumor growth delay resulting from combined use of Formula IV (at doses of 30 and 100 mg/kg) and gemcitabine hydrochloride (at a dose of 60 mg/kg); respectively.
Fig. 4 - displays various treatments for Panc-1 pancreatic carcinoma.
Bars (1), (2), and (3) display tumor growth delay resulting from use of LTBg inhibitor, Formula IV, alone at doses of 30, 100, and 200 mg/kg, respectively.
Bar (4) display tumor growth delay for the anti-cancer agent, gemcitabine hydrochloride, alone at a dose of 60 mg/kg.
Bars (5), (6) and (7) display tumor growth delay resulting from combined use of Formula IV (at doses of 30, 100 and 200 mg/kg) and gemcitabine hydrochloride (at a dose of 60 mg/kg); respectively.
Fig. 5 - displays various treatments for Human H460 non-Small cell Lung carcinoma.
Bars (1), (2), and (3) display tumor growth delay resulting from use of LTB4 inhibitor, Formula IV, alone at doses of 30, 100, and 200 mg/kg, respectively.
Bar (4) display tumor growth delay for the anti-cancer agent, gemcitabine hydrochloride, alone at a dose of 60 mg/kg.
Bars (5),(6) and (7) display tumor growth delay resulting from combined use of Formula IV (at doses of 30, 100 and 200 mg/kg), and gemcitabine hydrochloride (at a dose of 60 mg/kg); respectively.

Fig. 6 - displays various treatments for Calu-6 non-small cell Lung carcinoma.
Bars (1), (2), and (3) display tumor growth delay resulting from use of LTB4 inhibitor, Formula IV, alone at doses of 30, 100 and 200 mg/kg, respectively.
Bar (4) display tumor growth delay for the anti-cancer agent, gemcitabine hydrochloride, alone at a dose of 60 mg/kg.
Bars (5) and (6) display tumor growth delay resulting from combined use of Formula IV (at doses of 30 and 100 mg/kg) and gemcitabine hydrochloride (at a dose of 60 mg/kg); respectively.

Claims (40)

What is claimed is:
We Claim:

1. A composition of matter comprising a therapeutically effective amount of leukotriene (LTB4) antagonist and a therapeutically effective amount of 2',2'-difluoronucleoside anti-cancer agent.

2. A composition of matter comprising a therapeutically effective amount of leukotriene (LTBg) antagonist and a therapeutically effective amount of 2',2'-difluoronucleoside anti-cancer wherein the anti-cancer compound is a therapeutically effective amount of a compound represented by the formula:
where:
R1 is hydrogen;
R2 is a base defined by one of the formulae:
X is C-R4;
R3 is hydrogen;
R4 is hydrogen, C1-C4 alkyl, bromo, fluoro, chloro or iodo;
and pharmaceutically acceptable salts thereof.

3. The composition of claim 2 wherein R2 is the base defined by the formula:

4. The composition of claim 2 wherein the anti-cancer agent is selected from the group consisting of the following compounds or a pharmaceutically acceptable salt thereof:

(i) 1-(4-amino-2-oxo-1H-pyrimidin-1-yl)-2-desoxy-2',2'-difluororibose, (ii) 1-(4-amino-2-oxo-1H-pyrimidin-1-yl)-2-desoxy-2',2'-difluoroxylose, (iii) 1-(2,4-dioxo-1H,3H-pyrimidin-1-yl)-2-desoxy-2',2'-difluororibose, and (iv) 1-(4-amino-5-methyl-2-oxo-1H-pyrimidin-1-yl)-2-desoxy-2',2'-difluororibose.

5. The composition of claim 2 wherein the anti-cancer agent is gemcitabine hydrochloride.

6. The composition of claim 1 or 2 or 3 or 4 or 5 wherein the leukotriene (LTB4) antagonist is represented by the formula (I) wnerein:
X is selected from the group consisting of, (i) a five membered substituted or unsubstituted heterocyclic radical containing from 1 to 4 hetero atoms independently selected from sulfur, nitrogen or oxygen; and (ii) a fused bicyclic radical wherein a carbocyclic group is fused to two adjacent carbon atoms of the five membered heterocyclic radical, (i);
Y1 is a bond or divalent linking group containing 1 to 9 atoms;
Y2 and Y3 are divalent linking groups independently selected from -CH2-, -O-, or -S-;
Z is an Acidic Group;
R1 is C1-C10 alkyl, aryl, C3-C8 cycloalkyl, C2-C10 alkenyl, C2-C10 alkynyl, C6-C20 aralkyl, C6-C20 alkaryl, C1-C10 haloalkyl, C6-C20 aryloxy, or C1-C10 alkoxy;
R2 is hydrogen, halogen, C1-C10 haloalkyl, C1-C10 alkoxy, C1-C10 alkyl, C3-C8 cycloalkyl, Acidic Group, or -(CH2)1-7-(Acidic Group);
R3 is hydrogen, halogen, C1-C10 alkyl, aryl, C1-C10 haloalkyl, C1-C10 alkoxy, C6-C20 aryloxy, or C3-C8 cycloalkyl;
R4 is C1-C4 alkyl, C3-C4 cycloalkyl, -(CH2)1-7-(C3-C4 cycloalkyl), C2-C4 alkenyl, C2-C4 alkynyl, benzyl, or aryl; and n is 0, 1, 2, 3, 4, 5, or 6;
or a pharmaceutically acceptable salt, solvate, or prodrug derivative thereof.

7. The composition of claim 6 wherein X is a heterocyclic radical selected from the group consisting of substituents represented by the following formulae:
where R10 is a radical selected from hydrogen or C1-C4 alkyl; and R11 is a radical selected from hydrogen, halo, C1-C10 alkyl, C1-C10 haloalkyl, C1-C10 alkoxy, aryl, or C6-C20 aryloxy.

8. The composition of claim 6 wherein the R1, R2, R3 and R4 groups for substitution in formula (I) are selected from the following variables coded R01 thru R16 R variables R1 R2 R3 R4 Combination group group group group Code choice choice choice choice and;

the Y1, Y2, and Y3 groups for substitution in formula (I) are selected from the following variables coded Y01 thru Y27:
Y variables Y1 group Y2 group Y3 group combination choice choice choice code and;

the X and Z groups and the n variable for substitution in formula (I) are selected from the following variables coded XZn01 thru XZn24:
XZn variables X Z n integer combination group Group group code choice Choice choice XZn01 X Z n XZn02 X Z PG1-n XZn03 X Z PG2-n XZn04 X PG1-Z n XZn05 X PG2-Z n XZn06 X PG3-Z n XZn07 X PG1-Z PG1-n XZn08 X PG2-Z PG1-n XZn09 X PG3-Z PG1-n XZn10 X PG1-Z PG2-n XZn11 X PG2-Z PG2-n XZn12 X PG3-Z PG2-n XZn13 PG1-X Z n XZn14 PG1-X Z PG1-n XZn15 PG1-X Z PG2-n XZn16 PG1-X PG1-Z n XZn17 PG1-X PG2-Z n XZn18 PG1-X PG3-Z n XZn19 PG2-X PG1-Z PG1-n XZn20 PG2-X PG2-Z PG1-n XZn21 PG2-X PG3-Z PG1-n XZn22 PG2-X PG1-Z PG2-n XZn23 PG2-X PG2-Z PG2-n XZn24 PG2-X PG3-Z PG2-n

9. The composition of claim 6 wherein the leukotriene B4 antagonist is described by formula (II):

wherein;
X2 is a heterocyclic radical selected from, R21 is ethyl, 2-propen-1-yl, 3-propen-1-yl, n-propyl, iso-propyl, n-butyl, sec-butyl, or tert-butyl; and R22 is hydrogen, n-butyl, sec-butyl, flouro, chloro, -CF3, or tert-butyl.
Z2 is the Acidic Group selected from carboxyl, tetrazolyl, or N-sulfonamidyl;
or a salt, solvate or prodrug thereof.

10. The composition of claim 9 wherein the leukotriene antagonist is a compound selected from the following:
or an acid, salt, solvate or prodrug derivative thereof.

11. The composition of claim 9 wherein the leukotriene antagonist is a compound selected from the following:

or an acid, salt, solvate or prodrug derivative thereof.

12. The composition of claim 1 or 2 or 3 or 4 or 5 wherein the leukotriene (LTB4) antagonist is represented by a compound of the structure (Formula A):
or a pharmaceutically acceptable base addition salt thereof, wherein:
R1' is C1-C5 alkyl, C2-C5 alkenyl, C2-C5 alkynyl, C1-C4 alkoxy, (C1-C4 alkyl)thio, halo, or R2-substitutedphenyl;
each R2' and R3' are each independently hydrogen, halo, hydroxy, C1-C4 alkyl, C1-C4 alkoxy, (C1-C4 alkyl)-(O)q S-, trifluoromethyl, or di-(C1-C3 alkyl)amino;
X' is -O-, -S-, -C(=O), or -CH2-;
Y' is -O- or -CH2-;
or when taken together, -X'-Y'- is -CH=CH- or -C.ident.C-;
Z' is a straight or branched chain C1-C10 alkylidenyl;
A' is a bond, -O-, -S-, -CH=CH-, or -CR a R b-, where Ra and R b are each independently hydrogen, C1-C5 alkyl, or R7-substituted phenyl, or when taken together with the carbon atom to which they are attached form a C4-C8 cycloalkyl ring;
R4' is R6, wherein:
each R6 is independently -COOH, 5-tetrazolyl, -CON(R9)2, or -CONHSO2R10;
each R7 is hydrogen, C1-C4 alkyl, C2-C5 alkenyl, C2-C5 alkynyl, benzyl, methoxy, -W-R6, -T-G-R6, (C1-C4 alkyl)-T-(C1-C4 alkylidenyl)-O-, or hydroxy;
R8 is hydrogen or halo;
each R9 is independently hydrogen, phenyl, or C1-C4 alkyl, or when taken together with the nitrogen atom form a morpholino, piperidino, piperazino, or pyrrolidino group;
R10 is C1-C4 alkyl or phenyl;

R11 is R2', -W-R6, or -T-G-R6;
each W is a bond or a straight or branched chain divalent hydrocarbyl radical of one to eight carbon atoms;
each G is a straight or branched chain divalent hydrocarbyl radical of one. to eight carbon atoms;
each T is a bond, -CH2-, -O-, -NH-, -NHCO-, -C(=O)-, or (O) q S-;
K is -C(=O)- or -CH(OH)-;
each q is independently 0, 1, or 2;
p is 0 or 1; and t is 0 or 1;
provided when X is -O- or -S-, Y is not -O-;
provided when A is -O- or -S-, R4' is not R6;
and provided W is not a bond when p is 0.

13. The composition of claim 12 wherein R4' is selected from the following formulae:

14. The composition of claim 13 wherein R4' is:

15. The composition according to claim 12 wherein the LTB4 antagonist compound or pharmaceutically acceptable acid or prodrug or salt derivative thereof is selected from the group (A) to (KKKK) consisting of:
:
A) 2-Methyl-2-(1H-tetrazol-5-yl)-7-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)heptane;
B) 2-Methyl-2-(1H-tetrazol-5-yl)-7-(2-ethyl-4-(3-fluorophenyl)-5-hydroxyphenoxy)heptane;
C) 3-(2-(3-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)-6-(4-dimethylaminocarbonylbutyloxy)phenyl)propion is acid;
D) 3-(2-(3-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)phenyl)propionic acid;
E) 3-(2-(3-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)-6-(4-carboxybutyloxy)phenyl)propionic acid;
F) 3-(2-(3-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)-6-methoxyphenyl)propionic acid;
G) 3-(2-(3-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)-6-(4-(1H-tetrazol-5-yl)butyloxy)phenyl)propionic acid;

H) Methyl 3-(2-(4-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)-(1-butenyl))phenyl)propionate;
I) 3-(2-(4-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)-(1-butenyl))phenyl)propionic acid;
J) 3-(2-(4-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)butyl)phenyl)propionic acid;
K) 3-(2-(4-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)butyl)-6-methoxyphenyl)propionic acid;
L) Methyl 3-(2-(3-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)-6-hydroxyphenyl)propionate;
M) 3-(2-(3-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)-6-hydroxyphenyl)propionic acid;
N) 3-(2-(3-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)-6-(4-butyloxy)phenyl)propionic acid;
O) 3-(2-(3-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)-6-(4-methylthiobutyloxy)phenyl)propionic acid;
P) 3-(2-(3-(2,4-Di(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)-6-(4-carboxybutoxy)phenyl)propionic acid;
Q) 6-Methyl-6-(1H-tetrazol-5-yl)-11-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)undecane;
R) N,N-Dimethyl-3-(2-(3-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)phenyl)propionamide;
S) N-Methanesulfonyl-3-(2-(3-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)phenyl)propionamide;

T) N-Phenylsulfonyl-3-(2-(3-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)phenyl)propionamide;
U) 3-(2-(3-(2-Butyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)phenyl)propionic acid;
V) Ethyl 3-(2-(4-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)butyloxy)phenyl)propionate;
W) 3-(2-(4-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)butyloxy)phenyl)propionic acid;
X) Methyl 3-(2-(3-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)-6-(4-(methoxycarbonyl)phenoxy)phenyl)propionate;
Y) 3-(2-(3-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)-6-(4-carboxyphenoxy)phenyl)propionic acid;
Z) 3-(2-(3-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)-4-(4-carboxyphenoxy)phenyl)propionic acid;
AA) 3,3-Dimethyl-3-(2-(3-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)phenyl)propionic acid;
BB) 2-Methyl-2-(1H-tetrazol-5-yl)-3-(2-(3-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)phenyl)propane;
CC) 2-Methyl-2-(1H-tetrazol-5-yl)-3-hydroxy-3-(2-(3-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)phenyl)propane;
DD) 3-(2-(3-(2-Bromo-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)phenyl)propionic acid;
EE) 3-(2-(3-(2-Ethylthio-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)phenyl)propionic acid;

FF) Methyl 3-(2-hydroxy-3-(4-methoxycarbonylbutyl)-6-(3-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)phenyl)propionate;
GG) 5-(3-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)-8-(4-carboxybuty 1)dihydrocoumarin;
HH) 2-Phenyl-4-ethyl-5-[6-(2H-tetrazol-5-yl)-6-methylheptyloxy]phenol sodium salt;
II) 2-(4-Methylphenyl)-4-ethyl-5-[6-methyl-6-(2H-tetrazol-5-yl)heptyloxy]phenol disodium salt;
JJ) 2-(3-Methylphenyl)-4-ethyl-5-[6-methyl-6-(2H-tetrazol-5-yl)heptyloxy]phenol sodium salt;
KK) 2-(2-Methylphenyl)-4-ethyl-5-[6-methyl-6-(2H-tetrazol-5-yl)heptyloxy]phenol disodium salt;
LL) 2-(4-Methoxyphenyl)-4-ethyl-5-[6-methyl-6-(2H-tetrazol-5-yl)heptyloxy]phenol sodium salt;
MM) 2-(3-Methoxyphenyl)-4-ethyl-5-[6-methyl-6-(2H-tetrazol-5-yl)heptyloxy]phenol sodium salt;
NN) 2-(4-Trifluoromethylphenyl)-4-ethyl-5-[6-methyl-6-(2H-tetrazol-5-yl)heptyloxy]phenol disodium salt;
OO) 2-(3-Dimethylaminophenyl)-4-ethyl-5-[6-methyl-6-(2H-tetrazol-5-yl)heptyloxy]phenol disodium salt;
PP) 3-(5-(6-(4-Phenyl-5-hydroxy-2-ethylphenoxy)propoxy)-2-carboxymethyl-1,2,3,4 -tetrahydronaphthalen-1(2H)-one)propanoic acid;
QQ) 3-(5-(6-(4-(4-Fluorophenyl)-5-hydroxy-2-ethylphenoxy)propoxy)-2-carboxymeth yl-1,2,3,4-tetrahydronaphthalen-1(2H)-one)propanoic acid;
RR) 3-(4-(5-(4-(4-Fluorophenyl)-5-hydroxy-2-ethylphenoxy)propoxy)-2-carboxymeth yl-2,3-dihydroinden-1(2H)-one)propanoic acid;
SS) 3,3-Dimethyl-5-(3-(2-carboxyethyl)-4-(3-(4-fluorophenyl)-5-hydroxy-2-ethylphenoxy)propoxy)phenyl)-5-oxopentanoic acid;
TT) 7-[3-[(5-Ethyl-2-hydroxy[1,1'-biphenyl]-4-yl)oxy]propoxy]-3,4-dihydro-8-propyl-2H-1-benzopyran-2-carboxylic acid;
UU) 8-Propyl-7-[3-[4-(4-fluorophenyl)-2-ethyl-5-hydroxyphenoxy]propoxy]-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid;
VV) 2-[3-[3-[(5-Ethyl-2-hydroxy[1,1'-biphenyl]-4-yl)oxy]propoxy]-2-propylphenoxy]propanoic acid;
WW) 2-(4-Chlorophenyl)-4-ethyl-5-[6-methyl-6-(2H-tetrazol-5-yl)heptyloxy]phenol monosodium salt;
XX) 2-(3,5-Dichlorophenyl)-4-ethyl-5-[6-methyl-6-(2H-tetrazol-5-yl)heptyloxy]phenol monosodium salt;
YY) 3-[2-[3-[(5-Ethyl-2-hydroxy[1,1'-biphenyl]-4-yl)oxy]propoxy]-1-dibenzofuran]propanoic acid disodium salt;
ZZ) 7-Carboxy-9-oxo-3-[3-(2-ethyl-5-hydroxy-4-phenylphenoxy)propoxy]-9H-xanthene-4-propanoic acid disodium salt monohydrate;
AAA) 2-[2-Propyl-3-[3-(2-ethyl-5-hydroxy-4-phenylphenoxy)propoxy]phenoxy]benzoic acid sodium salt hemihydrate;
BBB) 3-[3-(2-Ethyl-5-hydroxy-4-phenylphenoxy)propoxy][1,1'-biphenyl]-4-propanoic acid disodium salt monohydrate;

CCC) 5-Ethyl-4-[3-[2-propyl-3-[2-(2H-tetrazol-5-yl)phenoxy]phenoxy]propoxy][1,1'-biphenyl]-2-ol disodium salt sesquihydrate;
DDD) 3-[4-[3-[ 3-(2-Ethyl-5-hydroxy-4-phenylphenoxy)propoxy]-9-oxo-9H-xanthene]]propanoic acid sodium salt hemihydrate;
EEE) 2-Fluoro-6-[2-propyl-3-[3-(2-ethyl-5-hydroxy-4-phenylphenoxy)propoxy]phenoxy]benzoic acid disodium salt;
FFF) 2-[2-Propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]phenoxy]benzoic acid sodium salt;
GGG) 3-[4-[7-Carboxy-9-oxo-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]-9H-xanthene]] propanoic acid disodium salt trihydrate;
HHH) 3-[4-[9-Oxo-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]-9H-xanthene]]propanoic acid;
III) 3-[2-[1-[2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]-4-(5-oxo-5-morpholinopentanamido)phenyl]propanoic acid;
JJJ) 2-Fluoro-6-[2-propyl-3-[3-[2-ethyl-5-hydroxy-4-(4-fluorophenyl)phenoxy]propoxy]phenoxy]benzoic acid disodium salt hydrate;
KKK) 4-Fluoro-2-[2-propyl-3-[3-[2-ethyl-5-hydroxy-4-(4-fluorophenyl)phenoxy]propoxy]phenoxy]benzoic acid;
LLL) 2-[2-Propyl-3-[5-[2-ethyl-5-hydroxy-4-(4-fluorophenyl)phenoxy]pentoxy]phenoxy]benzoic acid;

MMM) 2-[2-Propyl-3-[4-[2-ethyl-5-hydroxy-4-(4-fluorophenyl)phenoxy]butoxy]phenoxy]benzoic acid sesquihydrate;
NNN) 2-[2-(2-Methylpropyl)-3-[3-[2-ethyl-5-hydroxy-4-(4-fluorophenyl)phenoxy]propoxy]phenoxy]benzoic acid;
OOO) 2-[2-Butyl-3-[3-[2-ethyl-5-hydroxy-4-(4-fluorophenyl)phenoxy]propoxy]phenoxy]benzoic acid hydrate;
PPP) 2-[2-(Phenylmethyl)-3-[3-[2-ethyl-5-hydroxy-4-(4-fluorophenyl)phenoxy]propoxy]phenoxy]benzoic acid;
QQQ) 2-[2-Propyl-3-[3-[2-ethyl-5-hydroxy-4-(4-fluorophenyl)phenoxy]propoxy]phenoxy]phenyla cetic acid;
RRR) 2-[2-Propyl-3-[3-[2-ethyl-5-hydroxy-4-(4-fluorophenyl)phenoxy]propoxy]benzoyl]benzoic acid;
SSS) 2-[[2-Propyl-3-[3-[2-ethyl-5-hydroxy-4-(4-fluorophenyl)phenoxy]propoxy]phenyl]methyl]b enzoic acid;
TTT) 2-[2-Propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]thiophenoxy]benzoic acid;
UUU) 2-[2-Propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]phenylsulfinyl]benzoi c acid;
VVV) 2- [2-Propyl-3- [3- [2-ethyl-4- (4-fluorophenyl)-5-hydroxyphenoxy]propoxy]phenylsulfonyl]benzoi c acid hydrate;
WWW) 5-[3-[2-(1-Carboxy)ethyl]-4-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]phenyl]-4-pentynoic acid disodium salt 0.4 hydrate;
XXX) 1-Phenyl-1- (1H-tetrazol-5-yl ) -6- (2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)hexane;
YYY) 1-(4-(Carboxymethoxy)phenyl)-1-(1H-tetrazol-5-yl)-6-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)hexane;
ZZZ) 1-(4-(Dimethylaminocarbonylmethoxy)phenyl)-1-(1H-tetrazol-5-yl)-6-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)hexane;
AAAA) 3-(2-(3-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)phenyl)-E-propenoic acid;
BBBB) 3-(2-(3-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)phenyl)-2-methyl-E-propenoic acid;
CCCC) 5-(2-(2-(3-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)phenyl)ethyl)-1H-tetrazole;
DDDD) 3-(2-(3-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)-4-(4-carboxybutyloxy)phenyl)propionic acid;
EEEE) 5-[3-[4-(4-Fluorophenyl)-2-ethyl-5-hydroxyphenoxy]propoxy]-3,4-dihydro-2H-1-benzopyran-2-one;
FFFF) 3-(3-{3-[2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenyloxy]propoxy}phenyl)propanoic acid;
GGGG) 3-(3-(3-[2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenyloxy]propoxy}-4-propylph enyl)propanoic acid sodium salt;
HHHH) 3-(4-{3-[2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenyloxy]propoxy}-3-propylphenyl)propanoic acid;

IIII) 3-(3-{3-[2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenyloxy]propoxy}-2-propylphenyl)propanoic acid;
JJJJ) 3-{3-[3-(2-Ethyl-5-hydroxyphenyloxy)propoxy]-2-propylphenyl}propanoic acid disodium salt;
and KKKK) 2-[3-[3-[2-Ethyl-5-hydroxy-4-(4-fluorophenyl)phenoxy]propoxy]benzoyl]benzoic acid disodium salt hemihydrate.

16. The composition of claim 1 or 2 or 5 wherein the leukotriene (LTB4) antagonist is a compound of the structure (Formula B):
namely,2-[2-propyl-3-[3-[2-ethyl-5-hydroxy-4-(4-fluorophenyl)phenoxy]propoxy] phenoxy benzoic acid, or the pharmaceutically acceptable salt thereof.

17. The composition of claim 1 wherein the anti-cancer agent is a therapeutically effective amount of a 2',2'-difluoronucleoside anti-cancer agent according to the formula:

wherein:
R1 is hydrogen or R2 is a base defined by one of the formulae X is N or C-R4 R3 is hydrogen, C1-C4 alkyl or R4 is hydrogen, C1-C4 alkyl, amino, bromo, fluoro, chloro or iodo;
each R5 independently is hydrogen or C1-C4 alkyl; and the pharmaceutically-acceptable salts thereof.

18. The composition of claim 1 or 2 or 3 or 6 or 12 wherein the weight ratio of LTB4 antagonist to anti-cancer agent 1:100 to 100 to 1.

19. The composition of claim 1 or 2 or 3 or 6 or 12 in the form of injectable solution.

20. Use of the composition of matter containing leukotriene (LTB4) antagonist and anti-cancer agent of any one of claims 1 or 2 or or 3 or 4 or 5 or 6 or 7 or 8 or 9 or 10 or 12 or 13 or 14 or 15 or 16 or 17 for the manufacture of a medicament for the treatment of cancer in mammals.

21. A method of treating cancer in a mammalian patient by administering to said patient a therapeutically effective amount of a leukotriene (LTB4) antagonist and a therapeutically effective amount of 2',2'-difluoronucleoside anti-cancer agent.

22. The method of claim 21 wherein the anti-cancer compound is a therapeutically effective amount of a compound represented by the formula:
where:
R1 is hydrogen;

R2 is a base defined by one of the formulae:
X is C-R4;
R3 is hydrogen;
R4 is hydrogen, C1-C4 alkyl, bromo, fluoro, chloro or iodo;
and pharmaceutically acceptable salts thereof.

23. The method of claim 22 wherein R2 is the base defined by the formula:

24. The method of claim 23 wherein the anti-cancer agent is selected from the group consisting of the following compounds or a pharmaceutically acceptable salt thereof:
(i) 1-(4-amino-2-oxo-1H-pyrimidin-1-yl)-2-desoxy-2',2'-difluororibose, (ii) 1-(4-amino-2-oxo-1H-pyrimidin-1-yl)-2-desoxy-2',2'-difluoroxylose, (iii) 1-(2,4-dioxo-1H,3H-pyrimidin-1-yl)-2-desoxy-2',2'-difluororibose, and (iv) 1-(4-amino-5-methyl-2-oxo-1H-pyrimidin-1-yl)-2-desoxy-2',2'-difluororibose.

25. The method of claim 22 wherein the anti-cancer agent is gemcitabine hydrochloride.

26. The method of claim 21 or 22 or 23 or 24 or 25 wherein the leukotriene (LTB4) antagonist is represented by the formula (I) wherein:
X is selected from the group consisting of, (i) a five membered substituted or unsubstituted heterocyclic radical containing from 1 to 4 hetero atoms independently selected from sulfur, nitrogen or oxygen; and (ii) a fused bicyclic radical wherein a carbocyclic group is fused to two adjacent carbon atoms of the five membered heterocyclic radical, (i);
Y1 is a bond or divalent linking group containing 1 to 9 atoms;
Y2 and Y3 are divalent linking groups independently selected from -CH2-, -O-, or -S-;
Z is an Acidic Group;
R1 is C1-C10 alkyl, aryl, C3-C8 cycloalkyl, C2-C10 alkenyl, C2-C10 alkynyl, C6-C20 aralkyl, C6-C20 alkaryl, C1-Cl0 haloalkyl, C6-C20 aryloxy, or C1-C10 alkoxy;

R2 is hydrogen, halogen, C1-C10 haloalkyl, C1-C10 alkoxy, C1-C10 alkyl, C3-C8 cycloalkyl, Acidic Group, or -(CH2)1-7-(Acidic Group);
R3 is hydrogen, halogen, C1-C10 alkyl, aryl, C1-C10 haloalkyl, C1-C10 alkoxy, C6-C20 aryloxy, or C3-C8 cycloalkyl;
R4 is C1-C4 alkyl, C3-C4 cycloalkyl, -(CH2)1-7-(C3-C4 cycloalkyl), C2-C4 alkenyl, C2-C4 alkynyl, benzyl, or aryl; and n is 0, 1, 2, 3, 4, 5, or 6;
or a pharmaceutically acceptable salt, solvate, or prodrug derivative thereof.

27. The method of claim 26 wherein X is a heterocyclic radical selected from the group consisting of substituents represented by the following formulae:
where R10 is a radical selected from hydrogen or C1-C4 alkyl; and R11 is a radical selected from hydrogen, halo, C1-C10 alkyl, C1-C10 haloalkyl, C1-C10 alkoxy, aryl, or C6-C20 aryloxy.

28. The method of claim 26 wherein the R1, R2, R3 and R4 groups for substitution in formula (I) are selected from the following variables coded R01 through R16 R variables R1 R2 R3 R4 Combination group group group group Code choice choice choice choice R06 R1 PGl-R2 R3 PG1-R4 and;
the Y1, Y2, and Y3 groups for substitution in formula (I) are selected from the following variables coded Y01 thru Y27:
Y variables Y1 group Y2 group Y3 group combination choice choice choice code and;

the X and Z groups and the n variable for substitution in formula (I) are selected from the following variables coded XZn01 thru XZn24:
XZn variables X Z n integer combination group Group group code choice Choice choice XZn01 X Z n XZn02 X Z PG1-n XZn03 X Z PG2-n XZn04 X PG1-Z n XZn05 X PG2-Z n XZn06 X PG3-Z n XZn07 X PG1-Z PG1-n XZn08 X PG2-Z PG1-n XZn09 X PG3-Z PG1-n XZn10 X PG1-Z PG2-n XZn11 X PG2-Z PG2-n XZn12 X PG3-Z PG2-n XZn13 PG1-X Z n XZn14 PG1-X Z PG1-n XZn15 PG1-X Z PG2-n XZn16 PG1-X PG1-Z n XZn17 PG1-X PG2-Z n XZn18 PG1-X PG3-Z n XZn19 PG2-X PG1-Z PG1-n XZn20 PG2-X PG2-Z PG1-n XZn21 PG2-X PG3-Z PG1-n XZn22 PG2-X PG1-Z PG2-n XZn23 PG2-X PG2-Z PG2-n XZn24 PG2-X PG3-Z PG2-n

29. The method of claim 26 wherein the leukotriene B4 antagonist is described by formula (II):

wherein;
X2 is a heterocyclic radical selected from, (IMGS>

R21 is ethyl, 2-propen-1-yl, 3-propen-1-yl, n-propyl, iso-propyl, n-butyl, sec-butyl, or tert-butyl; and R22 is hydrogen, n-butyl, sec-butyl, flouro, chloro, -CF3, or tert-butyl.
Z2 is the Acidic Group selected from carboxyl, tetrazolyl, or N-sulfonamidyl;
or a salt, solvate or prodrug thereof.

30. The method of claim 26 wherein the leukotriene antagonist is a compound selected from the following:

or an acid, salt, solvate or prodrug derivative thereof.

31. The method of claim 26 wherein the leukotriene antagonist is a compound selected from the following:

or an acid, salt, solvate or prodrug derivative thereof.

32. The method of claim 21 or 22 or 23 or 24 or 25 wherein the leukotriene (LTB4) antagonist is represented by a compound of the structure (Formula A):
or a pharmaceutically acceptable base addition salt thereof, wherein:
R1' is C1-C5 alkyl, C2-C5 alkenyl, C2-C5 alkynyl, C1-C4 alkoxy, (C1-C4 alkyl)thio, halo, or R2-substitutedphenyl;
each R2' and R3' are each independently hydrogen, halo, hydroxy, C1-C4 alkyl, C1-C4 alkoxy, (C1-C4 alkyl)-(O)q S-, trifluoromethyl, or di-(C1-C3 alkyl)amino;
X' is -O-, -S-, -C(=O), or -CH2-;
Y' is -O- or -CH2-;
or when taken together, -X'-Y'- is -CH=CH- or -C.ident.C-;
Z' is a straight or branched chain C1-C10 alkylidenyl;
A' is a bond, -O-, -S-, -CH=CH-, or -CR a R b-, where R a and R b are each independently hydrogen, C1-C5 alkyl, or R7-substituted phenyl, or when taken together with the carbon atom to which they are attached form a C4-C8 cycloalkyl ring;
R4' is R6, wherein:
each R6 is independently -COOH, 5-tetrazolyl, -CON(R9)2, or -CONHSO2R10;
each R7 is hydrogen, C1-C4 alkyl, C2-C5 alkenyl, C2-C5 alkynyl, benzyl, methoxy, -W-R6, -T-G-R6, (C1-C4 alkyl)-T-(C1-C4 alkylidenyl)-O-, or hydroxy;
R8 is hydrogen or halo;
each R9 is independently hydrogen, phenyl, or C1-C4 alkyl, or when taken together with the nitrogen atom form a morpholino, piperidino, piperazino, or pyrrolidino group;
R10 is C1-C4 alkyl or phenyl;

R11 is R2', -W-R6, or -T-G-R6;
each W is a bond or a straight or branched chain divalent hydrocarbyl radical of one to eight carbon atoms;
each G is a straight or branched chain divalent hydrocarbyl radical of one to eight carbon atoms;
each T is a bond, -CH2-, -O-, -NH-, -NHCO-, -C(=O)-, or (O)q S-;
K is -C(=O)- or -CH(OH)-;
each q is independently 0, 1, or 2;
p i s 0 or 1; and t is 0 or 1;
provided when X is -O- or -S-, Y is not -O-;
provided when A is -O- or -S-, R4' is not R6;
and provided W is not a bond when p is 0.

33. The method of claim 32 wherein R4' is selected from the following formulae:

34. The method of claim 32 wherein R4' is:

35. The method according to claim 32 wherein the LTB4 antagonist compound or pharmaceutically acceptable acid or prodrug or salt derivative thereof is selected from the group (A) to (KKKK) consisting of:
a) 2-Methyl-2-(1H-tetrazol-5-yl)-7-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)heptane;
b) 2-Methyl-2-(1H-tetrazol-5-yl)-7-(2-ethyl-4-(3-fluorophenyl)-5-hydroxyphenoxy)heptane;
c) 3-(2-(3-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)-6-(4-dimethylaminocarbonylbutyloxy)phenyl)propionic acid;
d) 3-(2-(3-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)phenyl)propionic acid;
e) 3-(2-(3-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)-6-(4-carboxybutyloxy)phenyl)propionic acid;
f) 3-(2-(3-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)-6-methoxyphenyl)propionic acid;
g) 3-(2-(3-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)-6-(4-(1H-tetrazol-5-yl)butyloxy)phenyl)propionic acid;
h) Methyl 3-(2-(4-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)-(1-butenyl))phenyl)propionate;

i) 3-(2-(4-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)-(1-butenyl))phenyl)propionic acid;
j) 3-(2-(4-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)butyl)phenyl)propionic acid;
k) 3-(2-(4-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)butyl)-6-methoxyphenyl)propionic acid;
l) Methyl 3-(2-(3-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)-6-hydroxyphenyl)propionate;
m) 3-(2-(3-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)-6-hydroxyphenyl)propionic acid;
n) 3-(2-(3-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)-6-(4-butyloxy)phenyl)propionic acid;
o) 3-(2-(3-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)-6-(4-methylthiobutyloxy)phenyl)propionic acid;
p) 3-(2-(3-(2,4-Di-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)-6-(4-carboxybutoxy)phenyl)propionic acid;
q) 6-Methyl-6-(1H-tetrazol-5-yl)-11-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)undecane;
r) N,N-Dimethyl-3-(2-(3-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)phenyl)propionamide;
s) N-Methanesulfonyl-3-(2-(3-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)phenyl)propionamide;
t) N-Phenylsulfonyl-3-(2-(3-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)phenyl)propionamide;
u) 3-(2-(3-(2-Butyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)phenyl)propionic acid;
v) Ethyl 3-(2-(4-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)butyloxy)phenyl)propionate;
w) 3-(2-(4-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)butyloxy)phenyl)propionic acid;

x) Methyl 3-(2-(3-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)-6-(4-(methoxycarbonyl)phenoxy)phenyl)propionate;
y) 3-(2-(3-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)-6-(4-carboxyphenoxy)phenyl)propionic acid;
z) 3-(2-(3-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)-4-(4-carboxyphenoxy)phenyl)propionic acid;
aa) 3,3-Dimethyl-3-(2-(3-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)phenyl)propionic acid;
bb) 2-Methyl-2-(1H-tetrazol-5-yl)-3-(2-(3-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)phenyl)propane;
cc) 2-Methyl-2-(1H-tetrazol-5-yl)-3-hydroxy-3-(2-(3-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)phenyl)propane;
dd) 3-(2-(3-(2-Bromo-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)phenyl)propionic acid;
ee) 3-(2-(3-(2-Ethylthio-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)phenyl)propionic acid;
ff) Methyl 3-(2-hydroxy-3-(4-methoxycarbonylbutyl)-6-(3-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)phenyl)propionate;
gg) 5-(3-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)-8-(4-carboxybuty 1)dihydrocoumarin;
hh) 2-Phenyl-4-ethyl-5-[6-(2H-tetrazol-5-yl)-6-methylheptyloxy]phenol sodium salt;
ii) 2-(4-Methylphenyl)-4-ethyl-5-[6-methyl-6-(2H-tetrazol-5-yl)heptyloxy]phenol disodium salt;
jj) 2-(3-Methylphenyl)-4-ethyl-5-[6-methyl-6-(2H-tetrazol-5-yl)heptyloxy]phenol sodium salt;
kk) 2-(2-Methylphenyl)-4-ethyl-5-[6-methyl-6-(2H-tetrazol-5-yl)heptyloxy]phenol disodium salt;

11) 2-(4-Methoxyphenyl)-4-ethyl-5-[6-methyl-6-(2H-tetrazol-5-yl)heptyloxy]phenol sodium salt;
mm) 2-(3-Methoxyphenyl)-4-ethyl-5-[6-methyl-6-(2H-tetrazol-5-yl)heptyloxy]phenol sodium salt;
nn) 2-(4-Trifluoromethylphenyl)-4-ethyl-5-[6-methyl-6-(2H-tetrazol-5-yl)heptyloxy]phenol disodium salt;
oo) 2-(3-Dimethylaminophenyl)-4-ethyl-5-[6-methyl-6-(2H-tetrazol-5-yl)heptyloxy]phenol disodium salt;
pp) 3-(5-(6-(4-Phenyl-5-hydroxy-2-ethylphenoxy)propoxy)-2-carboxymethyl-1,2,3,4 -tetrahydronaphthalen-1(2H)-one)propanoic acid;
qq) 3-(5-(6-(4-(4-Fluorophenyl)-5-hydroxy-2-ethylphenoxy)propoxy)-2-carboxymeth yl-1,2,3,4-tetrahydronaphthalen-1(2H)-one)propanoic acid;
rr) 3-(4-(5-(4-(4-Fluorophenyl)-5-hydroxy-2-ethylphenoxy)propoxy)-2-carboxymeth yl-2,3-dihydroinden-1(2H)-one)propanoic acid;
ss) 3,3-Dimethyl-5-(3-(2-carboxyethyl)-4-(3-(4-fluorophenyl)-5-hydroxy-2-ethylphenoxy)propoxy)phenyl)-5-oxopentanoic acid;
tt) 7-[3-[(5-Ethyl-2-hydroxy[1,1'-biphenyl]-4-yl)oxy]propoxy]-3,4-dihydro-8-propyl-2H-1-benzopyran-2-carboxylic acid;
uu) 8-Propyl-7-[3-[4-(4-fluorophenyl)-2-ethyl-5-hydroxyphenoxy]propoxy]-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid;
w) 2-[3-[3-[(5-Ethyl-2-hydroxy[1,1'-biphenyl]-4-yl)oxy]propoxy]-2-propylphenoxy]propanoic acid;
ww) 2-(4-Chlorophenyl)-4-ethyl-5-[6-methyl-6-(2H-tetrazol-5-yl)heptyloxy]phenol monosodium salt;
xx) 2-(3,5-Dichlorophenyl)-4-ethyl-5-[6-methyl-6-(2H-tetrazol-5-yl)heptyloxy]phenol monosodium salt;
yy) 3-[2-[3-[(5-Ethyl-2-hydroxy[1,1'-biphenyl]-4-yl)oxy]propoxy]-1-dibenzofuran]propanoic acid disodium salt;

zz) 7-Carboxy-9-oxo-3-[3-(2-ethyl-5-hydroxy-4-phenylphenoxy)propoxy]-9H-xanthene-4-propanoic acid disodium salt monohydrate;
aaa) 2-[2-Propyl-3-[3-(2-ethyl-5-hydroxy-4-phenylphenoxy)propoxy]phenoxy]benzoic acid sodium salt hemihydrate;
bbb) 3-[3-(2-Ethyl-5-hydroxy-4-phenylphenoxy)propoxy][1,1' biphenyl]-4-propanoic acid disodium salt monohydrate;
ccc) 5-Ethyl-4-[3-[2-propyl-3-[2-(2H-tetrazol-5-yl)phenoxy]phenoxy]propoxy][1,1'-biphenyl]-2-ol disodium salt sesquihydrate;
ddd) 3-[4-[3-[ 3-(2-Ethyl-5-hydroxy-4-phenylphenoxy)propoxy]-9-oxo-9H-xanthene]]propanoic acid sodium salt hemihydrate;
eee) 2-Fluoro-6-[2-propyl-3-[3-(2-ethyl-5-hydroxy-4-phenylphenoxy)propoxy]phenoxy]benzoic acid disodium salt;
fff) 2-[2-Propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]phenoxy]benzoic acid sodium salt;
ggg) 3-[4-[7-Carboxy-9-oxo-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]-9H-xanthene]] propanoic acid disodium salt trihydrate;
hhh) 3-[4-[9-Oxo-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]-9H-xanthene]]propanoic acid;
iii) 3-[2-[1-[2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]-4-(5-oxo-5-morpholinopentanamido)phenyl]propanoic acid;
jjj) 2-Fluoro-6-[2-propyl-3-[3-[2-ethyl-5-hydroxy-4-(4-fluorophenyl)phenoxy]propoxy]phenoxy]benzoic acid disodium salt hydrate;
kkk) 4-Fluoro-2-[2-propyl-3-[3-[2-ethyl-5-hydroxy-4-(4 fluorophenyl)phenoxy]propoxy]phenoxy]benzoic acid;
lll) 2-[2-Propyl-3-[5-[2-ethyl-5-hydroxy-4-(4-fluorophenyl)phenoxy]pentoxy]phenoxy]benzoic acid;

mmm) 2-[2-Propyl-3-[4-[2-ethyl-5-hydroxy-4-(4-fluorophenyl)phenoxy]butoxy]phenoxy]benzoic acid sesquihydrate;
nnn) 2-[2-(2-Methylpropyl)-3-[3-[2-ethyl-5-hydroxy-4-(4 fluorophenyl)phenoxy]propoxy]phenoxy]benzoic acid;
ooo) 2-[2-Butyl-3-[3-[2-ethyl-5-hydroxy-4-(4-fluorophenyl)phenoxy]propoxy]phenoxy]benzoic acid hydrate;
ppp) 2-[2-(Phenylmethyl)-3-[3-[2-ethyl-5-hydroxy-4-(4 fluorophenyl)phenoxy]propoxy]phenoxy]benzoic acid;
qqq) 2-[2-Propyl-3-[3-[2-ethyl-5-hydroxy-4-(4-fluorophenyl)phenoxy]propoxy]phenoxy]phenylacetic acid;
rrr) 2-[2-Propyl-3-[3-[2-ethyl-5-hydroxy-4-(4-fluorophenyl)phenoxy]propoxy]benzoyl]benzoic acid;
sss) 2-[[2-Propyl-3-[3-[2-ethyl-5-hydroxy-4-(4-fluorophenyl)phenoxy]propoxy]phenyl]methyl]benzoic acid;
ttt) 2-[2-Propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5 hydroxyphenoxy]propoxy]thiophenoxy]benzoic acid;
uuu) 2-[2-Propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]phenylsulfinyl]benzoic acid;
vvv) 2- [2-Propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]phenylsulfonyl]benzoic acid hydrate;
www) 5-[3-[2-(1-Carboxy)ethyl]-4-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]phenyl]-4-pentynoic acid disodium salt 0.4 hydrate;
xxx) 1-Phenyl-1-(1H-tetrazol-5-yl)-6-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)hexane;
yyy) 1-(4-(Carboxymethoxy)phenyl)-1-(1H-tetrazol-5-yl)-6-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)hexane;
zzz) 1-(4-(Dimethylaminocarbonylmethoxy)phenyl)-1-(1H-tetrazol-5-yl)-6-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)hexane;

aaaa) 3-(2-(3-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)phenyl)-E-propenoic acid;
bbbb) 3-(2-(3-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)phenyl)-2-methyl-E-propenoic acid;
cccc) 5-(2-(2-(3-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)phenyl)ethyl)-1H-tetrazole;
dddd) 3-(2-(3-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)-4-(4-carboxybutyloxy)phenyl)propionic acid;
eeee) 5-[3-[4-(4-Fluorophenyl)-2-ethyl-5-hydroxyphenoxy]propoxy]-3,4-dihydro-2H-1-benzopyran-2-one;
ffff) 3-(3-{3-[2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenyloxy]propoxy}phenyl)propanoic acid;
gggg) 3-(3-{3-[2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenyloxy]propoxy}-4-propylph enyl)propanoic acid sodium salt;
hhhh) 3-(4-{3-[2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenyloxy]propoxy}-3-propylphenyl)propanoic acid;
iiii) 3-(3-{3-[2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenyloxy]propoxy}-2-propylphenyl)propanoic acid;
jjjj) 3-{3-[3-(2-Ethyl-5-hydroxyphenyloxy)propoxy]-2-propylphenyl}propanoic acid disodium salt; and kkkk) 2-[3-[3-[2-Ethyl-5-hydroxy-4-(4-fluorophenyl)phenoxy]propoxy]benzoyl]benzoic acid disodium salt hemihydrate.

36. The method of claim 21 or 22 or 25 wherein the leukotriene (LTB4) antagonist is a compound of the structure (Formula B):
Formula B
Namely, 2-[2-propyl-3-[3-[2-ethyl-5-hydroxy-4-(4-fluorophenyl)phenoxy]propoxy]phenoxy benzoic acid, and the pharmaceutically acceptable salts thereof.

37. The method of claim 21 wherein the anti-cancer agent is a therapeutically effective amount of a 2',2'-difluoronucleoside anti-cancer agent according to the formula:
wherein:
R1 is hydrogen or R2 is a base defined by one of the formulae X is N or C-R4 R3 is hydrogen, C1-C4 alkyl or R4 is hydrogen, C1-C4 alkyl, amino, bromo, fluoro, chloro or iodo;
each R5 independently is hydrogen or C1-C4 alkyl; and the pharmaceutically-acceptable salts thereof.

38. A method of treating cancer in a mammalian patient by administering to said patient a therapeutically effective amount of a leukotriene (LTB4) antagonist and a therapeutically effective amount of 2',2'-difluoronucleoside anti-cancer agent; wherein the anti-cancer agent is gemcitabine hydrochloride and the leukotriene (LTB4) antagonist is a compound of the structure (Formula B):

or pharmaceutically acceptable salts thereof.

39. The method of claim 21 or 22 or 38 wherein the weight ratio of LTB4 antagonist to anti-cancer agent 1:100 to 100 to 1.

40. The method of claim 21 or 22 or 23 wherein the combined dose weight of LTB4 antagonist and anti-cancer agentin from 0.5 to about 300 mg/kg per day.