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CA2377513A1 - Peptides bispirales a hetero-association - Google Patents

Peptides bispirales a hetero-association Download PDF

Info

Publication number
CA2377513A1
CA2377513A1 CA002377513A CA2377513A CA2377513A1 CA 2377513 A1 CA2377513 A1 CA 2377513A1 CA 002377513 A CA002377513 A CA 002377513A CA 2377513 A CA2377513 A CA 2377513A CA 2377513 A1 CA2377513 A1 CA 2377513A1
Authority
CA
Canada
Prior art keywords
poly
peptide
hetero
associating
peptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002377513A
Other languages
English (en)
Inventor
Andreas Pluckthun
Katja Arndt
Kristian Muller
Joelle Pelletier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zurich Universitaet Institut fuer Medizinische Virologie
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2377513A1 publication Critical patent/CA2377513A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1055—Protein x Protein interaction, e.g. two hybrid selection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

L'invention concerne des procédés relatifs à l'identification de peptides bispiralés à hétéro-association et les utilisations de ces peptides pour l'hétérodimérisation de protéines de fusion. L'invention concerne en outre des vecteurs et des cellules hôtes utiles pour l'élaboration des peptides considérés, ainsi que des (poly)peptides/protéines renfermant lesdits peptides.
CA002377513A 1999-06-25 2000-06-26 Peptides bispirales a hetero-association Abandoned CA2377513A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34409699A 1999-06-25 1999-06-25
US09/344,096 1999-06-25
PCT/EP2000/005922 WO2001000814A2 (fr) 1999-06-25 2000-06-26 Peptides bispirales a hetero-association

Publications (1)

Publication Number Publication Date
CA2377513A1 true CA2377513A1 (fr) 2001-01-04

Family

ID=23349034

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002377513A Abandoned CA2377513A1 (fr) 1999-06-25 2000-06-26 Peptides bispirales a hetero-association

Country Status (3)

Country Link
EP (1) EP1194539A2 (fr)
CA (1) CA2377513A1 (fr)
WO (1) WO2001000814A2 (fr)

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US7192596B2 (en) * 1996-08-23 2007-03-20 The Health Protection Agency Ipsen Limited Recombinant toxin fragments
US20030035798A1 (en) 2000-08-16 2003-02-20 Fang Fang Humanized antibodies
CA2377573A1 (fr) * 1999-06-26 2001-01-04 Joelle Nina Pelletier Selection in vivo bibliotheque contre bibliotheque d'interactions proteine-proteine optimisees
US7030219B2 (en) 2000-04-28 2006-04-18 Johns Hopkins University B7-DC, Dendritic cell co-stimulatory molecules
ES2370417T3 (es) 2005-06-03 2011-12-15 Ares Trading S.A. Producción de una proteína de unión a il-18 recombinante.
ES2395969T3 (es) * 2006-03-24 2013-02-18 Merck Patent Gmbh Dominios de proteínas heterodiméricas genéticamente modificados
US7989173B2 (en) 2006-12-27 2011-08-02 The Johns Hopkins University Detection and diagnosis of inflammatory disorders
KR20110074850A (ko) 2008-08-25 2011-07-04 앰플리뮨, 인크. Ｐｄ-１ 길항제 및 그의 사용 방법
FR2948940B1 (fr) 2009-08-04 2011-07-22 Servier Lab Nouveaux derives dihydroindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
JP2013503205A (ja) 2009-08-31 2013-01-31 アンプリミューン， インコーポレイテッド 移植拒絶反応を阻害するための方法および組成物
US20150231215A1 (en) 2012-06-22 2015-08-20 Randolph J. Noelle VISTA Antagonist and Methods of Use
US10745467B2 (en) 2010-03-26 2020-08-18 The Trustees Of Dartmouth College VISTA-Ig for treatment of autoimmune, allergic and inflammatory disorders
NZ602634A (en) 2010-03-26 2015-06-26 Dartmouth College Vista regulatory t cell mediator protein, vista binding agents and use thereof
CN103068399A (zh) 2010-06-30 2013-04-24 卡姆普根有限公司 用于治疗多发性硬化、类风湿性关节炎以及其他自身免疫病症的c1orf32
US8999335B2 (en) 2010-09-17 2015-04-07 Compugen Ltd. Compositions and methods for treatment of drug resistant multiple myeloma
JP2014517685A (ja) 2011-04-15 2014-07-24 コンピュゲン エルティーディー． 免疫関連疾患およびがんの治療のためのポリペプチドおよびポリヌクレオチドならびにそれらの使用
CA2836855C (fr) 2011-06-30 2020-07-14 Compugen Ltd. Polypeptides et leurs utilisations pour traiter les troubles auto-immuns et l'infection
WO2013192504A1 (fr) 2012-06-22 2013-12-27 The Trustees Of Dartmouth College Nouveaux produits de recombinaison vista-ig et leur utilisation dans le traitement des troubles autoimmuns, allergiques et inflammatoires
US9890215B2 (en) 2012-06-22 2018-02-13 King's College London Vista modulators for diagnosis and treatment of cancer
EP3578660A1 (fr) * 2012-07-05 2019-12-11 F. Hoffmann-La Roche AG Système d'expression et de sécrétion
CN109793893B (zh) 2012-09-07 2023-05-26 达特茅斯大学理事会 用于诊断和治疗癌症的vista调节剂
RS60026B1 (sr) 2013-02-18 2020-04-30 Vegenics Pty Ltd Molekuli koji vezuju ligande i njihove upotrebe
AU2014265142A1 (en) 2013-05-17 2015-12-24 Medimmune, Llc Receptors for B7-H4
US11014987B2 (en) 2013-12-24 2021-05-25 Janssen Pharmaceutics Nv Anti-vista antibodies and fragments, uses thereof, and methods of identifying same
DK3087098T3 (da) 2013-12-24 2020-06-08 Janssen Pharmaceutica Nv Anti-Vista-antistoffer og -fragmenter
CA2951885C (fr) 2014-06-11 2023-07-04 Kathy A. Green Utilisation d'antagonistes et d'agonistes vista pour supprimer ou ameliorer l'immunite humorale
JP2016002009A (ja) * 2014-06-13 2016-01-12 国立大学法人名古屋大学 タグ付抗体
US20170275344A1 (en) 2014-08-26 2017-09-28 Compugen Ltd. Polypeptides and uses thereof as a drug for treatment of autoimmune disorders
JP2018505911A (ja) 2014-12-05 2018-03-01 イミュネクスト，インコーポレーテッド 推定上のｖｉｓｔａ受容体としてのｖｓｉｇ８の同定と、ｖｉｓｔａ／ｖｓｉｇ８調節剤を産生するためのその使用
CN114805576A (zh) 2015-06-24 2022-07-29 詹森药业有限公司 抗vista抗体和片段
AU2016291846B2 (en) 2015-07-13 2022-05-26 Compugen Ltd. HIDE1 Compositions and Methods
BR112018016461A2 (pt) 2016-02-12 2019-10-01 Janssen Pharmaceutica Nv anticorpos e fragmentos anti-vista, usos dos mesmos e métodos de identificação dos mesmos
CN117562992A (zh) 2016-04-15 2024-02-20 伊穆奈克斯特股份有限公司 抗人vista抗体及其用途
WO2018027042A1 (fr) 2016-08-03 2018-02-08 Bio-Techne Corporation Identification de vsig3/vista comme nouveau point de contrôle immunitaire et son utilisation en immunothérapie
AU2017371225A1 (en) 2016-12-09 2019-05-16 Seagen Inc. Bivalent antibodies masked by coiled coils
US11787857B2 (en) 2018-02-02 2023-10-17 Bio-Techne Corporation Compounds that modulate the interaction of VISTA and VSIG3 and methods of making and using
AU2019265699A1 (en) * 2018-05-08 2021-01-07 Amgen Inc. Bispecific antibodies with cleavable C-terminal charge-paired tags
WO2022227066A1 (fr) * 2021-04-30 2022-11-03 深圳普瑞金生物药业有限公司 PROCÉDÉ POUR LE CRIBLAGE DE MUTANTS D'HETERODIMÈRES αβ-TCR

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2196496A1 (fr) * 1997-01-31 1998-07-31 Stephen William Watson Michnick Epreuve de complementation de fragments de proteines pour la detection d'interactions entre proteines

Also Published As

Publication number Publication date
WO2001000814A3 (fr) 2001-03-22
EP1194539A2 (fr) 2002-04-10
WO2001000814A2 (fr) 2001-01-04

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Legal Events

Date Code Title Description
FZDE Discontinued
FZDE Discontinued

Effective date: 20050627