CA2376204A1 - Cosmetic depilation kit with photosensitizer - Google Patents
Cosmetic depilation kit with photosensitizer Download PDFInfo
- Publication number
- CA2376204A1 CA2376204A1 CA002376204A CA2376204A CA2376204A1 CA 2376204 A1 CA2376204 A1 CA 2376204A1 CA 002376204 A CA002376204 A CA 002376204A CA 2376204 A CA2376204 A CA 2376204A CA 2376204 A1 CA2376204 A1 CA 2376204A1
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- Prior art keywords
- kit according
- illumination
- light
- cosmetic kit
- skin
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- Abandoned
Links
- 239000002537 cosmetic Substances 0.000 title claims description 21
- 230000035617 depilation Effects 0.000 title description 9
- 239000003504 photosensitizing agent Substances 0.000 title description 2
- 238000005286 illumination Methods 0.000 claims abstract description 40
- 239000000463 material Substances 0.000 claims abstract description 37
- 231100000331 toxic Toxicity 0.000 claims abstract description 30
- 230000002588 toxic effect Effects 0.000 claims abstract description 30
- 239000003550 marker Substances 0.000 claims abstract description 25
- 239000000126 substance Substances 0.000 claims abstract description 24
- 230000003779 hair growth Effects 0.000 claims abstract description 19
- 239000012876 carrier material Substances 0.000 claims abstract description 17
- 230000003993 interaction Effects 0.000 claims abstract description 10
- 230000000694 effects Effects 0.000 claims abstract description 4
- 238000007920 subcutaneous administration Methods 0.000 claims abstract description 3
- 230000002401 inhibitory effect Effects 0.000 claims description 4
- 239000000835 fiber Substances 0.000 claims description 2
- 210000003491 skin Anatomy 0.000 description 27
- 210000004027 cell Anatomy 0.000 description 19
- 238000000034 method Methods 0.000 description 17
- 210000004209 hair Anatomy 0.000 description 12
- ZGXJTSGNIOSYLO-UHFFFAOYSA-N 88755TAZ87 Chemical compound NCC(=O)CCC(O)=O ZGXJTSGNIOSYLO-UHFFFAOYSA-N 0.000 description 11
- 210000000130 stem cell Anatomy 0.000 description 10
- 229940079593 drug Drugs 0.000 description 7
- 239000003814 drug Substances 0.000 description 7
- 229960002749 aminolevulinic acid Drugs 0.000 description 6
- 210000001519 tissue Anatomy 0.000 description 6
- 230000001681 protective effect Effects 0.000 description 5
- 230000006378 damage Effects 0.000 description 4
- 210000002615 epidermis Anatomy 0.000 description 3
- 210000003780 hair follicle Anatomy 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 238000005253 cladding Methods 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 239000013583 drug formulation Substances 0.000 description 2
- 239000003974 emollient agent Substances 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 210000001732 sebaceous gland Anatomy 0.000 description 2
- 239000004065 semiconductor Substances 0.000 description 2
- 238000006424 Flood reaction Methods 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- WYTGDNHDOZPMIW-RCBQFDQVSA-N alstonine Natural products C1=CC2=C3C=CC=CC3=NC2=C2N1C[C@H]1[C@H](C)OC=C(C(=O)OC)[C@H]1C2 WYTGDNHDOZPMIW-RCBQFDQVSA-N 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 230000031774 hair cycle Effects 0.000 description 1
- 210000004919 hair shaft Anatomy 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000013011 mating Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 238000001126 phototherapy Methods 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000037390 scarring Effects 0.000 description 1
- 231100000075 skin burn Toxicity 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/062—Photodynamic therapy, i.e. excitation of an agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B18/203—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser applying laser energy to the outside of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00452—Skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00452—Skin
- A61B2018/00476—Hair follicles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B2018/1807—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using light other than laser radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
- A61N2005/0643—Applicators, probes irradiating specific body areas in close proximity
- A61N2005/0644—Handheld applicators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
- A61N2005/0643—Applicators, probes irradiating specific body areas in close proximity
- A61N2005/0645—Applicators worn by the patient
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Surgery (AREA)
- Pathology (AREA)
- Chemical & Material Sciences (AREA)
- Optics & Photonics (AREA)
- Molecular Biology (AREA)
- Radiology & Medical Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Otolaryngology (AREA)
- Medical Informatics (AREA)
- Electromagnetism (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Radiation-Therapy Devices (AREA)
- Laser Surgery Devices (AREA)
Abstract
A marker substance includes a photosensitive toxic material to tag subcutaneous hair growth cells of a target zone of skin. Illumination apparatus is used to illuminate the skin in the target zone with light of a wavelength selected to effect preferential interaction with the hair growth cells tagged with the marker substance, resulting in a toxic effect inhibiti ng the hair growth capability of the tagged illuminated cells; wherein. In the kit the marker substance may be provided in a form comprising discrete portions of the photosensitive toxic material and a carrier material, the portions to be mixed prior to application to the target zone. Additionally o r alternatively, the illumination apparatus includes an applicator configured to deliver non-laser light and/or configured to be placed against the target zo ne skin to deliver the illumination to the tagged hair growth cells.
Description
COSMETIC DEPILATION KTT WITH PHOTOSENSITIZER
The present invention relates to a cosmetic depilation kit.
Laser hair removal is currently an effective and long term method for effecting cosmetic hair removal. An exemplary laser depilation technique is disclosed in EP-A-0732895.
In such techniques, high intensity laser energy is directed towards the skin selectively heating hair surrounding the follicle leading to damage of the hair growth mechanism. If sufficient damage is induced, the hair follicle is effectively destroyed and the hair will not regrow. This technique has disadvantages, one such being that scarring and pigmentary changes can occur.
This is particularly the case where the individual being treated has dark skin and/or light hair. Such techniques are also relatively slow, with the target zone needing to be covered by repeated laser pulses.
US-A-5669916 discloses a technique in which a hair is first plucked from a follicle before a photosensitive toxic material is directed along the path of the removed hair to the follicle. The toxic material is then activated by irradiation using laser.
An improved technique has now been devised.
The present invention relates to a cosmetic depilation kit.
Laser hair removal is currently an effective and long term method for effecting cosmetic hair removal. An exemplary laser depilation technique is disclosed in EP-A-0732895.
In such techniques, high intensity laser energy is directed towards the skin selectively heating hair surrounding the follicle leading to damage of the hair growth mechanism. If sufficient damage is induced, the hair follicle is effectively destroyed and the hair will not regrow. This technique has disadvantages, one such being that scarring and pigmentary changes can occur.
This is particularly the case where the individual being treated has dark skin and/or light hair. Such techniques are also relatively slow, with the target zone needing to be covered by repeated laser pulses.
US-A-5669916 discloses a technique in which a hair is first plucked from a follicle before a photosensitive toxic material is directed along the path of the removed hair to the follicle. The toxic material is then activated by irradiation using laser.
An improved technique has now been devised.
According to a first aspect, the present invention provides a cosmetic kit for use in inhibiting hair growth, the kit comprising:
a) a marker substance including a photosensitive toxic material to tag subcutaneous hair growth cells of a target zone of skin; and, b) illumination apparatus for illuminating the skin in the target zone with light of a wavelength selected to effect preferential interaction with the hair growth cells tagged with the marker substance, resulting in a toxic effect inhibiting the hair growth capability of the tagged illuminated cells; wherein:
(i) the marker substance is provided in a form comprising discrete portions of the photosensitive toxic material and a carrier material, the portions to be mixed prior to application to the target zone; and or, (ii) the illumination apparatus includes an applicator configured to deliver non-laser light and/or configured to be placed against the target zone skin to deliver the illumination to the tagged hair growth cells.
The photosensitive toxic material is a material whose toxicity increases substantially upon exposure illumination of predetermined wavelength at sufficient energy delivered. One such material is ALA
(aminolevulinic acid); this and other materials are known in~the art and described, for example in US-A-5669916.
The carrier material is beneficially a material easily absorbed into the skin an preferably comprises a moisturiser or absorbent emollient carrying the photosensitive toxic material in dissolved form or otherwise. It is important to maintain the carrier aid the photosensitive toxic material separate until shortly prior to use in order to inhibit any adverse interaction between the materials prior to application to the skin of the target zone.
The portions of the photosensitive toxic material and the carrier material are dosed in a predetermined ratio. In one embodiment the proportion would be approximately 25%
photosensitive toxic material to approximately 75% carrier material.
The kit beneficially includes a dispenser or a container-dispenser for dispensing the marker substance.
A container for the carrier material and or the photosensitive toxic material preferably affords light shielding of the photosensitive toxic material.
Mixing means is beneficially provided for mixing the photosensitive toxic material and the carrier material.
The mixing means preferably permits mixing of the photosensitive toxic material and the carrier material at a zone substantially sealed from the user.
Beneficially a container for the photosensitive toxic material and the carrier material comprises respective sealed zones containing the photosensitive toxic material and the carrier material respectively, the zones being configured to be selectively breached or ruptured permitting mixing of the materials. A mixing zone may be provided adjacent the breathable sealed zones, the mixing zone preferably communicating with a dispensing outlet.
The illumination apparatus preferably includes window means arranged to overlay the target zone skin, the illumination being directed via the window means.
In one embodiment, the illumination apparatus includes an illumination applicator having a flexible structure arranged to conform to the target zone skin body part.
The illumination apparatus preferably includes:
a) an illumination applicator structure arranged to deliver illumination over a predetermined area;
b) a waveguide to connect with the illumination applicator; and, c) a light source to direct light along the waveguide.
_5-The illumination apparatus beneficially includes an illumination applicator structure having internal light reflecting walls and an associated light transmissive zone means through which reflected light is permitted to pass.
This may be achieved, for example, where the applicator structure comprises one or more lengths of fibreoptic (preferably the applicator structure comprises a plurality of lengths of fibre optic, the lengths being arranged to deliver light at different zones of the applicator structure).
The marker substance is desirably preferentially absorbed by, or tagged to, hair growth cells in the target zone.
The excess proportion of the applied marker substance not absorbed by the hair growth cells is preferably metabolised and removed from the tissue by the normal action of the body. The technique according to the invention has been found to be effective even without the prior mechanical/physical depilation suggested in US-A-5669916. Indeed such a step is discouraged due to the unnecessary trauma and pain it entails.
The hair growth cells targeted for tagging are preferably so called 'stem' cells in the 'bulge' area of the follicle (adjacent the sebaceous gland). By effectively destroying or disabling the 'stem' cells once the hair has completed a growth cycle, a new hair cycle will be inhibited from starting, thereby preventing the follicle from functioning properly. The marker substance is therefore selected to preferentially tag 'stem' cells.
The marker substance is preferably topically applied to the skin at the target zone. The marker substance penetrates into the skin to preferentially tag the target cells (typically by being preferentially absorbed). The marker substance preferably comprises a photo therapy drug such as for example 5-Aminolaevolinic Acid (5-ALA).
Desirably the drug is provided in a topically administrable form such as a cream or the like.
The interaction of the illuminating light with the marking substance preferably results in the desired hair growth inhibition. The interaction may be photochemical and/or photo-thermal in nature. For photochemical interaction, light of a predetermined wavelength induces a chemical reaction between the marker substance and the tagged cells resulting in destruction of, or disabling of, the tagged cells. For photo-thermal interaction, the incident light causes a temperature rise in the tagged cells to a degree sufficient to destroy or disable the tagged cell.
The wavelength of the illuminating light is preferably selected such that it is absorbed by the marker substance (or the tagged cell). The wavelength of the illuminating light is preferably substantially matched to the optical absorption characteristics of the marker substance.
The illuminating light is preferably substantially in the range 500nm-1000nm wavelength. The light is preferably concentrated within a relatively narrow bandwidth within the range. This may be achieved by filtering of the light or use of light emitting apparatus arranged to emit a discrete wavelength (or band of wavelengths) . For example where 5-ALA is used as the marker substance to tag the cells it is preferred that the illuminating light includes on. or more wavelengths substantially in the range 600nm 650nm.
The illuminating light may, for example, be laser (including semiconductor laser), white light (preferably filtered), or LED light.
The intensity of the light is determined by the quantity of light required to produce the necessary interaction with the tagged cells. Generally however the intensity required will be substantially lower than the intensity required for prior art laser depilation techniques. This enables the technique to be more suitable for unsupervised 'Home' use.
The light may be pulsed or applied as continuous wave. The light typically floods the target zone, which target zone is typically of an area in the range 0.5cm2-lOcm2, more preferably lcm2-5cm2. The energy applied per pulse to the target zone is preferably substantially in the range 40J
or less (more preferably 25J or less).
The possibility of using lower intensity and non-laser light also enables a greater area target zone to be simultaneously illuminated, with reduced risk of skin burn. The technique is therefore safer and quicker.
_g_ The invention will now be further described, in a specific embodiment, by way of example only and with reference to the accompanying drawings in which:
Figure 1 is a schematic representation of a mammalian hair follicle;
Figure 2 is a schematic representation, similar to Figure 1, showing a first stage in application of the depilation technique;
Figure 3 is a schematic representation similar to Figures 1 and 2, showing a subsequent stage in the technique;
Figures 4 and 5 are schematic plan and side views respectively of a container-dispenser for the marker substance according to the invention;
Figures 6 and 7 show alternative general embodiments of illumination apparatus for inclusion in a kit according to the invention;
Figure 8 is a schematic view of a laser diode illumination apparatus for inclusion in a kit according to the invention;
Figure 9 is a schematic view of LED illumination apparatus for inclusion in a kit according to the invention;
Figure 10 is a schematic view of 'white light' illumination apparatus for inclusion in a kit according to _g_ the invention;
Figure 11 is a schematic view of alternative 'white light' illumination apparatus for inclusion in a kit according to the invention;
Figure' 12 is a schematic view of a pad or patch applicator structure illumination apparatus for inclusion in a kit according to the invention;
Figure 13 is a perspective view of the applicator pad or patch of figure 12;
Figure 14 is a sectional view of the fibreoptic used in the pad or patch of figures 12 and 13; and Figure 15 is a schematic longitudinal section of the fibreoptic of figure 14.
Referring to the drawings and initially to Figure 1, there is shown human hair follicle supporting a hair shaft 1 growing through the epidermis 2 and dermis 3 of mammalian skin tissue. 'Stem' cells 7 are present in the 'bulge' region 4 adjacent the sebaceous gland 5. Stem cells have a relatively high turnover/life cycle and are responsible for instituting cyclical growth of the hair from the follicle.
In accordance with the invention, a drug formulation including 5-Aminolaevolinic Acid (5-ALA) is provided in a form for topical administration to the outer surface of the skin 6. The drug 5-ALA is selected because it is selectively absorbed and retained in stem cells 7 when penetrating into the epidermal layer 3 (via epidermis 2) thereby effectively tagging the stem cells.
Concentrations of the drug not absorbed in the stem cells 7 are metabolised and removed from the tissue by the normal'action of the body.
After a predetermining period of time to allow the excess "marker" drug to be removed from the target zone tissue (other than from the "tag" stem cells 7), the target zone of the skin is directly illuminated from externally of the body by means of an illumination device 9 which supplies light of a preselected wavelength matched to a preselected characteristic absorption wavelength of the marker drug (now tagging stem cells 7).
The intensity of the light supplied, and duration of supply of the light, is controlled such that either photochemical or photo-thermal interaction (or both) of the light with the tagged stem cells 7 causes disabling or destruction of the relevant stem cell 7 without disabling or destroying, substantially, the surrounding tissue material. This results in the tagged and disabled stem cell being inhibited from acting further to produce hair from the relevant follicle.
The technique, by selectively marking/tagging and destroying stem cells preferentially (and the associated matching of the wavelength of the illuminating light) enables relatively low intensity light to be used, which may flood the target zone of the skin enabling a relatively large area of hair covered skin to be treated simultaneously. Typically, the light from the illumination device 9 is pulsed to enable thermal relaxation of the skin to occur between consecutive pulses. Typically, the energy supplied to the skin surface by the illuminating device 9 does not exceed 25J, before significant thermal relaxation of the skin is permitted.
The illuminating device may comprise laser, semiconductor laser, white light illumination device (typically with a filter) or an LED device. The wavelength band width emitted where 5-ALA is used as the marker is preferably substantially within the range 600nm - 650nm (which may be achieved by filtering if required).
The low intensity nature of the light required to effect depilation using the technique according to the invention, enables the technique to be relatively safe when compared to prior art laser hair removal techniques. The drug formulation and illumination device may therefore be sold as a consumer kit for "home" use.
Referring to figures 4 to 15 a "home use" kit for cosmetic depilation would typically comprise a power supply and lighting apparatus 10, 11 (see figures 6 and 7) for direct connection to mains power supply. The apparatus 10, 11 either includes flexible electric connection to a light source 12 for application of illuminating radiation to the skin or, a "fixed" light source 13 and fibreoptic connection 14 to an applicator 16.
The other essential element of the kit is the market substance typically provided in a container 20 (see figures 4 and 5) which comprises a heat sealed plastics container/dispenser 20 having sealed chambers 21, 22, 23.
Chamber 21 contains the ALA material and chamber 23 carries the moisturiser/emollient carrier cream. A manual pinch pressure causes seals 24, 25 to be ruptured and tlae respective materials to be urged from chambers 21, 23 into mixing chamber 22 where they become thoroughly, and intimately, mixed. A cap 26 is subsequently broken from the end of nozzle 27 permitting the ALA and carrier mixture to be squeezed out of the container dispenser 20 under manual pressure.
The container dispenser 20 ensures that the correct proportions of ALA drug and carrier are mixed, and that mixing may be delayed until the point of application.
Following application of the mixture topically to the target zone of skin, and subsequently waiting the required length of time to permit the concentration of ALA in the non-target tissue to be reduced to the required low level, the illumination apparatus is applied to the skin and switched on.
Various forms of illuminating apparatus may be used. The apparatus 110 in figure 8 includes a laser diode light source 125 contained within a protective casing 126 and including focussing optics 127 arranged to ensure the light is directed through a protective window 128.
Typically the window 128 is held against the skin of the target zone to ensure correct delivery of the illuminating light to the target zone.
In the- embodiment shown in figure 9 a 2D array of LEDs (light emitting diodes) 225 is utilised. Focussing optics 227 ensure the light is directed through the protective window 228 in a similar manner to the arrangement of figure 8.
In the apparatus shown in figure 10, an electric filament "white light" source is used. The source 325 is surrounded by a protective housing 326 including a shaped reflective surface 327 arranged to direct the light out of the housing via protective window 328.
In the embodiment shown in figure 11, a white light filament source 325 is once again used. In this embodiment an internally reflecting light guide (such as a fibreoptic) is used. The fibreoptic may be connected to a light applicator to be connected to the skin as will be described hereafter.
The apparatus of figure 12 shows an applicator pad or patch structure 426 which is typically flexible in nature, permitting the pad 426 to be conformed to the shape of the body part to which it is applied. As shown in figures 13 to 15 additionally, light is directed to the pad or patch structure 426 by a flexible fibreoptic 435 which has a connector 436 arranged for mating connection to a corresponding connector 437 provided for the pad or patch structure. The pad or patch structure 426 has an imbedded fibreoptic arrangement 440 including a series of spaced lengths of fibreoptic 441 extending across the pad or patch structure. In the embodiment shown in figure 13, the fibreoptic path lengths form a serpentine arrangement, although a number of paths connected in parallel would also provide a convenient and workable arrangement. As shown in figure 14 the fibreoptic 440 includes .a reflective surface cladding 442 surrounding a core 443.
The surface cladding 442 ensures total internal reflection about the circumference of the fibreoptic except for an unclad window length 445 through which light can be emitted.
The pad or patch structure as shown in figures 12 to 15 provides a convenient arrangement in that light can be distributed widely over a large area of skin surface in a convenient and safe manner.
Particular benefits of the invention are the arrangement of the carrier and the photosensitive toxic material in discrete separate package portions, easily mixable at the required time in order to ensure that detrimental effects of early mixing or incorrect dosage ratios are avoided.
The illumination apparatus configured to deliver non-laser light and/or configured to be placed against the target zone skin provide additional safety benefits and ensure that the skin is radiated to a consistent degree during treatment. This makes the kit particularly suitable for consumer/home use.
a) a marker substance including a photosensitive toxic material to tag subcutaneous hair growth cells of a target zone of skin; and, b) illumination apparatus for illuminating the skin in the target zone with light of a wavelength selected to effect preferential interaction with the hair growth cells tagged with the marker substance, resulting in a toxic effect inhibiting the hair growth capability of the tagged illuminated cells; wherein:
(i) the marker substance is provided in a form comprising discrete portions of the photosensitive toxic material and a carrier material, the portions to be mixed prior to application to the target zone; and or, (ii) the illumination apparatus includes an applicator configured to deliver non-laser light and/or configured to be placed against the target zone skin to deliver the illumination to the tagged hair growth cells.
The photosensitive toxic material is a material whose toxicity increases substantially upon exposure illumination of predetermined wavelength at sufficient energy delivered. One such material is ALA
(aminolevulinic acid); this and other materials are known in~the art and described, for example in US-A-5669916.
The carrier material is beneficially a material easily absorbed into the skin an preferably comprises a moisturiser or absorbent emollient carrying the photosensitive toxic material in dissolved form or otherwise. It is important to maintain the carrier aid the photosensitive toxic material separate until shortly prior to use in order to inhibit any adverse interaction between the materials prior to application to the skin of the target zone.
The portions of the photosensitive toxic material and the carrier material are dosed in a predetermined ratio. In one embodiment the proportion would be approximately 25%
photosensitive toxic material to approximately 75% carrier material.
The kit beneficially includes a dispenser or a container-dispenser for dispensing the marker substance.
A container for the carrier material and or the photosensitive toxic material preferably affords light shielding of the photosensitive toxic material.
Mixing means is beneficially provided for mixing the photosensitive toxic material and the carrier material.
The mixing means preferably permits mixing of the photosensitive toxic material and the carrier material at a zone substantially sealed from the user.
Beneficially a container for the photosensitive toxic material and the carrier material comprises respective sealed zones containing the photosensitive toxic material and the carrier material respectively, the zones being configured to be selectively breached or ruptured permitting mixing of the materials. A mixing zone may be provided adjacent the breathable sealed zones, the mixing zone preferably communicating with a dispensing outlet.
The illumination apparatus preferably includes window means arranged to overlay the target zone skin, the illumination being directed via the window means.
In one embodiment, the illumination apparatus includes an illumination applicator having a flexible structure arranged to conform to the target zone skin body part.
The illumination apparatus preferably includes:
a) an illumination applicator structure arranged to deliver illumination over a predetermined area;
b) a waveguide to connect with the illumination applicator; and, c) a light source to direct light along the waveguide.
_5-The illumination apparatus beneficially includes an illumination applicator structure having internal light reflecting walls and an associated light transmissive zone means through which reflected light is permitted to pass.
This may be achieved, for example, where the applicator structure comprises one or more lengths of fibreoptic (preferably the applicator structure comprises a plurality of lengths of fibre optic, the lengths being arranged to deliver light at different zones of the applicator structure).
The marker substance is desirably preferentially absorbed by, or tagged to, hair growth cells in the target zone.
The excess proportion of the applied marker substance not absorbed by the hair growth cells is preferably metabolised and removed from the tissue by the normal action of the body. The technique according to the invention has been found to be effective even without the prior mechanical/physical depilation suggested in US-A-5669916. Indeed such a step is discouraged due to the unnecessary trauma and pain it entails.
The hair growth cells targeted for tagging are preferably so called 'stem' cells in the 'bulge' area of the follicle (adjacent the sebaceous gland). By effectively destroying or disabling the 'stem' cells once the hair has completed a growth cycle, a new hair cycle will be inhibited from starting, thereby preventing the follicle from functioning properly. The marker substance is therefore selected to preferentially tag 'stem' cells.
The marker substance is preferably topically applied to the skin at the target zone. The marker substance penetrates into the skin to preferentially tag the target cells (typically by being preferentially absorbed). The marker substance preferably comprises a photo therapy drug such as for example 5-Aminolaevolinic Acid (5-ALA).
Desirably the drug is provided in a topically administrable form such as a cream or the like.
The interaction of the illuminating light with the marking substance preferably results in the desired hair growth inhibition. The interaction may be photochemical and/or photo-thermal in nature. For photochemical interaction, light of a predetermined wavelength induces a chemical reaction between the marker substance and the tagged cells resulting in destruction of, or disabling of, the tagged cells. For photo-thermal interaction, the incident light causes a temperature rise in the tagged cells to a degree sufficient to destroy or disable the tagged cell.
The wavelength of the illuminating light is preferably selected such that it is absorbed by the marker substance (or the tagged cell). The wavelength of the illuminating light is preferably substantially matched to the optical absorption characteristics of the marker substance.
The illuminating light is preferably substantially in the range 500nm-1000nm wavelength. The light is preferably concentrated within a relatively narrow bandwidth within the range. This may be achieved by filtering of the light or use of light emitting apparatus arranged to emit a discrete wavelength (or band of wavelengths) . For example where 5-ALA is used as the marker substance to tag the cells it is preferred that the illuminating light includes on. or more wavelengths substantially in the range 600nm 650nm.
The illuminating light may, for example, be laser (including semiconductor laser), white light (preferably filtered), or LED light.
The intensity of the light is determined by the quantity of light required to produce the necessary interaction with the tagged cells. Generally however the intensity required will be substantially lower than the intensity required for prior art laser depilation techniques. This enables the technique to be more suitable for unsupervised 'Home' use.
The light may be pulsed or applied as continuous wave. The light typically floods the target zone, which target zone is typically of an area in the range 0.5cm2-lOcm2, more preferably lcm2-5cm2. The energy applied per pulse to the target zone is preferably substantially in the range 40J
or less (more preferably 25J or less).
The possibility of using lower intensity and non-laser light also enables a greater area target zone to be simultaneously illuminated, with reduced risk of skin burn. The technique is therefore safer and quicker.
_g_ The invention will now be further described, in a specific embodiment, by way of example only and with reference to the accompanying drawings in which:
Figure 1 is a schematic representation of a mammalian hair follicle;
Figure 2 is a schematic representation, similar to Figure 1, showing a first stage in application of the depilation technique;
Figure 3 is a schematic representation similar to Figures 1 and 2, showing a subsequent stage in the technique;
Figures 4 and 5 are schematic plan and side views respectively of a container-dispenser for the marker substance according to the invention;
Figures 6 and 7 show alternative general embodiments of illumination apparatus for inclusion in a kit according to the invention;
Figure 8 is a schematic view of a laser diode illumination apparatus for inclusion in a kit according to the invention;
Figure 9 is a schematic view of LED illumination apparatus for inclusion in a kit according to the invention;
Figure 10 is a schematic view of 'white light' illumination apparatus for inclusion in a kit according to _g_ the invention;
Figure 11 is a schematic view of alternative 'white light' illumination apparatus for inclusion in a kit according to the invention;
Figure' 12 is a schematic view of a pad or patch applicator structure illumination apparatus for inclusion in a kit according to the invention;
Figure 13 is a perspective view of the applicator pad or patch of figure 12;
Figure 14 is a sectional view of the fibreoptic used in the pad or patch of figures 12 and 13; and Figure 15 is a schematic longitudinal section of the fibreoptic of figure 14.
Referring to the drawings and initially to Figure 1, there is shown human hair follicle supporting a hair shaft 1 growing through the epidermis 2 and dermis 3 of mammalian skin tissue. 'Stem' cells 7 are present in the 'bulge' region 4 adjacent the sebaceous gland 5. Stem cells have a relatively high turnover/life cycle and are responsible for instituting cyclical growth of the hair from the follicle.
In accordance with the invention, a drug formulation including 5-Aminolaevolinic Acid (5-ALA) is provided in a form for topical administration to the outer surface of the skin 6. The drug 5-ALA is selected because it is selectively absorbed and retained in stem cells 7 when penetrating into the epidermal layer 3 (via epidermis 2) thereby effectively tagging the stem cells.
Concentrations of the drug not absorbed in the stem cells 7 are metabolised and removed from the tissue by the normal'action of the body.
After a predetermining period of time to allow the excess "marker" drug to be removed from the target zone tissue (other than from the "tag" stem cells 7), the target zone of the skin is directly illuminated from externally of the body by means of an illumination device 9 which supplies light of a preselected wavelength matched to a preselected characteristic absorption wavelength of the marker drug (now tagging stem cells 7).
The intensity of the light supplied, and duration of supply of the light, is controlled such that either photochemical or photo-thermal interaction (or both) of the light with the tagged stem cells 7 causes disabling or destruction of the relevant stem cell 7 without disabling or destroying, substantially, the surrounding tissue material. This results in the tagged and disabled stem cell being inhibited from acting further to produce hair from the relevant follicle.
The technique, by selectively marking/tagging and destroying stem cells preferentially (and the associated matching of the wavelength of the illuminating light) enables relatively low intensity light to be used, which may flood the target zone of the skin enabling a relatively large area of hair covered skin to be treated simultaneously. Typically, the light from the illumination device 9 is pulsed to enable thermal relaxation of the skin to occur between consecutive pulses. Typically, the energy supplied to the skin surface by the illuminating device 9 does not exceed 25J, before significant thermal relaxation of the skin is permitted.
The illuminating device may comprise laser, semiconductor laser, white light illumination device (typically with a filter) or an LED device. The wavelength band width emitted where 5-ALA is used as the marker is preferably substantially within the range 600nm - 650nm (which may be achieved by filtering if required).
The low intensity nature of the light required to effect depilation using the technique according to the invention, enables the technique to be relatively safe when compared to prior art laser hair removal techniques. The drug formulation and illumination device may therefore be sold as a consumer kit for "home" use.
Referring to figures 4 to 15 a "home use" kit for cosmetic depilation would typically comprise a power supply and lighting apparatus 10, 11 (see figures 6 and 7) for direct connection to mains power supply. The apparatus 10, 11 either includes flexible electric connection to a light source 12 for application of illuminating radiation to the skin or, a "fixed" light source 13 and fibreoptic connection 14 to an applicator 16.
The other essential element of the kit is the market substance typically provided in a container 20 (see figures 4 and 5) which comprises a heat sealed plastics container/dispenser 20 having sealed chambers 21, 22, 23.
Chamber 21 contains the ALA material and chamber 23 carries the moisturiser/emollient carrier cream. A manual pinch pressure causes seals 24, 25 to be ruptured and tlae respective materials to be urged from chambers 21, 23 into mixing chamber 22 where they become thoroughly, and intimately, mixed. A cap 26 is subsequently broken from the end of nozzle 27 permitting the ALA and carrier mixture to be squeezed out of the container dispenser 20 under manual pressure.
The container dispenser 20 ensures that the correct proportions of ALA drug and carrier are mixed, and that mixing may be delayed until the point of application.
Following application of the mixture topically to the target zone of skin, and subsequently waiting the required length of time to permit the concentration of ALA in the non-target tissue to be reduced to the required low level, the illumination apparatus is applied to the skin and switched on.
Various forms of illuminating apparatus may be used. The apparatus 110 in figure 8 includes a laser diode light source 125 contained within a protective casing 126 and including focussing optics 127 arranged to ensure the light is directed through a protective window 128.
Typically the window 128 is held against the skin of the target zone to ensure correct delivery of the illuminating light to the target zone.
In the- embodiment shown in figure 9 a 2D array of LEDs (light emitting diodes) 225 is utilised. Focussing optics 227 ensure the light is directed through the protective window 228 in a similar manner to the arrangement of figure 8.
In the apparatus shown in figure 10, an electric filament "white light" source is used. The source 325 is surrounded by a protective housing 326 including a shaped reflective surface 327 arranged to direct the light out of the housing via protective window 328.
In the embodiment shown in figure 11, a white light filament source 325 is once again used. In this embodiment an internally reflecting light guide (such as a fibreoptic) is used. The fibreoptic may be connected to a light applicator to be connected to the skin as will be described hereafter.
The apparatus of figure 12 shows an applicator pad or patch structure 426 which is typically flexible in nature, permitting the pad 426 to be conformed to the shape of the body part to which it is applied. As shown in figures 13 to 15 additionally, light is directed to the pad or patch structure 426 by a flexible fibreoptic 435 which has a connector 436 arranged for mating connection to a corresponding connector 437 provided for the pad or patch structure. The pad or patch structure 426 has an imbedded fibreoptic arrangement 440 including a series of spaced lengths of fibreoptic 441 extending across the pad or patch structure. In the embodiment shown in figure 13, the fibreoptic path lengths form a serpentine arrangement, although a number of paths connected in parallel would also provide a convenient and workable arrangement. As shown in figure 14 the fibreoptic 440 includes .a reflective surface cladding 442 surrounding a core 443.
The surface cladding 442 ensures total internal reflection about the circumference of the fibreoptic except for an unclad window length 445 through which light can be emitted.
The pad or patch structure as shown in figures 12 to 15 provides a convenient arrangement in that light can be distributed widely over a large area of skin surface in a convenient and safe manner.
Particular benefits of the invention are the arrangement of the carrier and the photosensitive toxic material in discrete separate package portions, easily mixable at the required time in order to ensure that detrimental effects of early mixing or incorrect dosage ratios are avoided.
The illumination apparatus configured to deliver non-laser light and/or configured to be placed against the target zone skin provide additional safety benefits and ensure that the skin is radiated to a consistent degree during treatment. This makes the kit particularly suitable for consumer/home use.
Claims (15)
1. A cosmetic kit for use in inhibiting hair growth, the kit comprising:
a) a marker substance including a photosensitive toxic material to tag subcutaneous hair growth cells of a target zone of skin; and, b) illumination apparatus for illuminating the skin in the target zone with light of a wavelength selected to effect preferential interaction with the hair growth cells tagged with the marker substance, resulting in a toxic effect inhibiting the hair growth capability of the tagged illuminated cells; wherein:
(i) the marker substance is provided in a form comprising discrete portions of the photosensitive toxic material and a carrier material, the portions to be mixed prior to application to the target zone; and or, (ii) the illumination apparatus includes an applicator configured to deliver non-laser light and/or configured to be placed against the target zone skin to deliver the illumination to the tagged hair growth cells.
a) a marker substance including a photosensitive toxic material to tag subcutaneous hair growth cells of a target zone of skin; and, b) illumination apparatus for illuminating the skin in the target zone with light of a wavelength selected to effect preferential interaction with the hair growth cells tagged with the marker substance, resulting in a toxic effect inhibiting the hair growth capability of the tagged illuminated cells; wherein:
(i) the marker substance is provided in a form comprising discrete portions of the photosensitive toxic material and a carrier material, the portions to be mixed prior to application to the target zone; and or, (ii) the illumination apparatus includes an applicator configured to deliver non-laser light and/or configured to be placed against the target zone skin to deliver the illumination to the tagged hair growth cells.
2. A cosmetic kit according to claim 1, wherein the portions of the photosensitive toxic material and the carrier material are dosed in a predetermined ratio.
3. A cosmetic kit according to claim 1 or claim 2, including a dispenser for dispensing the marker substance. ~
4. A cosmetic kit according to any preceding claim, including a container for the carrier material and or the photosensitive toxic material.
5. A cosmetic kit according to claim 4, wherein the container affords shielding of the photosensitive toxic material.
6. A cosmetic kit according to any preceding claim, wherein mixing means is provided for mixing the photosensitive toxic material and the carrier material.
7. A cosmetic kit according to claim 6, wherein the mixing means permits mixing of the photosensitive toxic material and the carrier material at a zone substantially sealed from the user.
8. A cosmetic kit according to any preceding claim, wherein a container for the photosensitive toxic material and the carrier material comprises respective sealed zones containing the photosensitive toxic material and the carrier material respectively, the zones being configured to be selectively breached or ruptured permitting mixing of the materials.
9. A cosmetic kit according to claim 8, wherein a mixing zone is provided adjacent the breachable sealed zones, the mixing zone communicating with a dispensing outlet.
10. A cosmetic kit according to any preceding claim, wherein the illumination apparatus includes window means surface arranged to overlay the target zone skin, the illumination being directed via the window means.
11. A cosmetic kit according to any preceding claim, wherein the illumination apparatus includes an illumination applicator having a flexible structure arranged to conform to the target zone skin body part.
12. A cosmetic kit according to any preceding claim, wherein the apparatus includes:
(a) an illumination applicator structure arranged to deliver illumination over a large area;
(b) a waveguide to connect with the illumination applicator; and, (c) a light source to direct light along the waveguide.
(a) an illumination applicator structure arranged to deliver illumination over a large area;
(b) a waveguide to connect with the illumination applicator; and, (c) a light source to direct light along the waveguide.
13. A cosmetic kit according to any preceding claim, wherein the apparatus includes an illumination applicator structure having internal light reflecting walls and an associated light transmissive zone means through which reflected light is permitted to pass.
14. A cosmetic kit according to claim 13, wherein the applicator structure comprises one or more lengths of fibreoptic.
15. A cosmetic kit according to claim 13 or claim 14, wherein the applicator structure comprises a plurality of lengths of fibre optic, the lengths being arranged to deliver light at different zones of the applicator.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9912998.3 | 1999-06-04 | ||
| GBGB9912998.3A GB9912998D0 (en) | 1999-06-04 | 1999-06-04 | Depilation |
| PCT/GB2000/002170 WO2000074781A1 (en) | 1999-06-04 | 2000-06-05 | Cosmetic depilation kit with photosensitizer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2376204A1 true CA2376204A1 (en) | 2000-12-14 |
Family
ID=10854730
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002376204A Abandoned CA2376204A1 (en) | 1999-06-04 | 2000-06-05 | Cosmetic depilation kit with photosensitizer |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP1183071A1 (en) |
| JP (1) | JP2003501168A (en) |
| KR (1) | KR20020023947A (en) |
| CN (1) | CN1353620A (en) |
| AU (1) | AU5094500A (en) |
| BR (1) | BR0012108A (en) |
| CA (1) | CA2376204A1 (en) |
| GB (1) | GB9912998D0 (en) |
| IL (1) | IL146816A0 (en) |
| MX (1) | MXPA01012416A (en) |
| NO (1) | NO20015808L (en) |
| WO (1) | WO2000074781A1 (en) |
| ZA (1) | ZA200109721B (en) |
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| WO1998051235A1 (en) | 1997-05-15 | 1998-11-19 | Palomar Medical Technologies, Inc. | Method and apparatus for dermatology treatment |
| DE69926348T2 (en) | 1998-03-12 | 2006-06-01 | Palomar Medical Technologies, Inc., Burlington | SYSTEM FOR THE ELECTROMAGNETIC IRRADIATION OF THE SKIN |
| ES2403359T3 (en) | 1998-03-27 | 2013-05-17 | The General Hospital Corporation | Procedure and apparatus for the selective determination of lipid rich tissues |
| US6514242B1 (en) | 1998-12-03 | 2003-02-04 | David Vasily | Method and apparatus for laser removal of hair |
| US6458257B1 (en) | 1999-02-09 | 2002-10-01 | Lynntech International Ltd | Microorganism control of point-of-use potable water sources |
| US6888319B2 (en) | 2001-03-01 | 2005-05-03 | Palomar Medical Technologies, Inc. | Flashlamp drive circuit |
| CN1966106A (en) * | 2001-03-02 | 2007-05-23 | 帕洛玛医疗技术公司 | Apparatus and method for photocosmetic and photodermatological treatment |
| DE10112470B4 (en) | 2001-03-15 | 2008-02-28 | Keller, Ruprecht, Priv.-Doz. Dr.Dr. | A method for sample identification in a mammal and kit for carrying out this method |
| CN102499755B (en) * | 2001-05-23 | 2014-11-12 | 帕洛玛医疗技术公司 | Cooling system for photocosmetic device |
| AU2002316500A1 (en) | 2001-07-02 | 2003-01-21 | Palomar Medical Technologies, Inc. | Laser device for medical/cosmetic procedures |
| AU2002367397A1 (en) | 2001-12-27 | 2003-07-24 | Palomar Medical Technologies, Inc. | Method and apparatus for improved vascular related treatment |
| EP1482848A4 (en) | 2002-03-12 | 2007-08-15 | Palomar Medical Tech Inc | METHOD AND APPARATUS FOR ACTIVATING CAPILLARY GROWTH |
| WO2004037287A2 (en) | 2002-05-23 | 2004-05-06 | Palomar Medical Technologies, Inc. | Phototreatment device for use with coolants and topical substances |
| US7276058B2 (en) | 2002-06-19 | 2007-10-02 | Palomar Medical Technologies, Inc. | Method and apparatus for treatment of cutaneous and subcutaneous conditions |
| AU2003238302B2 (en) | 2002-06-19 | 2008-12-11 | Palomar Medical Technologies, Inc | Method and apparatus for photothermal treatment of tissue at depth |
| WO2005065565A1 (en) | 2003-12-31 | 2005-07-21 | Palomar Medical Technologies, Inc. | Dermatological treatment with vusualization |
| US7856985B2 (en) | 2005-04-22 | 2010-12-28 | Cynosure, Inc. | Method of treatment body tissue using a non-uniform laser beam |
| JP5010327B2 (en) * | 2006-06-26 | 2012-08-29 | パナソニック株式会社 | Hair growth regulator |
| US7586957B2 (en) | 2006-08-02 | 2009-09-08 | Cynosure, Inc | Picosecond laser apparatus and methods for its operation and use |
| JP2008246144A (en) * | 2007-03-30 | 2008-10-16 | Matsushita Electric Works Ltd | Hair growth control method and apparatus |
| KR100817363B1 (en) * | 2007-04-09 | 2008-03-26 | 김동호 | Laser therapy |
| US9919168B2 (en) | 2009-07-23 | 2018-03-20 | Palomar Medical Technologies, Inc. | Method for improvement of cellulite appearance |
| WO2013158299A1 (en) | 2012-04-18 | 2013-10-24 | Cynosure, Inc. | Picosecond laser apparatus and methods for treating target tissues with same |
| EP3751684A1 (en) | 2013-03-15 | 2020-12-16 | Cynosure, Inc. | Picosecond optical radiation systems and methods of use |
| GB201310143D0 (en) * | 2013-06-07 | 2013-07-24 | Ambicare Health Ltd | Delivery Mechanism for Photodynamic Therapy |
| EP2957909B1 (en) | 2014-06-18 | 2019-01-30 | Ruprecht Keller | Method for identifying of a biological sample of a mammal and composition for use in this method |
| CN107149726A (en) * | 2017-06-21 | 2017-09-12 | 张健 | Weak pulse washes life cosmetology depilator off |
| AU2019225242B2 (en) | 2018-02-26 | 2023-08-10 | Cynosure, Llc | Q-switched cavity dumped sub-nanosecond laser |
| EP3782096B1 (en) | 2019-07-04 | 2023-06-07 | Ruma GmbH | Location-independent intake control |
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| US3736933A (en) * | 1970-12-02 | 1973-06-05 | B Szabo | Burstable seamed hypodermic applicators |
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| US5519534A (en) * | 1994-05-25 | 1996-05-21 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Irradiance attachment for an optical fiber to provide a uniform level of illumination across a plane |
| US5669916A (en) | 1994-09-28 | 1997-09-23 | The General Hospital Corporation | Method of hair removal |
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-
1999
- 1999-06-04 GB GBGB9912998.3A patent/GB9912998D0/en not_active Ceased
-
2000
- 2000-06-05 IL IL14681600A patent/IL146816A0/en unknown
- 2000-06-05 EP EP00935403A patent/EP1183071A1/en not_active Withdrawn
- 2000-06-05 CA CA002376204A patent/CA2376204A1/en not_active Abandoned
- 2000-06-05 JP JP2001501311A patent/JP2003501168A/en not_active Withdrawn
- 2000-06-05 KR KR1020017015638A patent/KR20020023947A/en not_active Withdrawn
- 2000-06-05 WO PCT/GB2000/002170 patent/WO2000074781A1/en not_active Application Discontinuation
- 2000-06-05 CN CN00808387A patent/CN1353620A/en active Pending
- 2000-06-05 BR BR0012108-8A patent/BR0012108A/en not_active Application Discontinuation
- 2000-06-05 AU AU50945/00A patent/AU5094500A/en not_active Abandoned
- 2000-06-05 MX MXPA01012416A patent/MXPA01012416A/en unknown
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2001
- 2001-11-27 ZA ZA200109721A patent/ZA200109721B/en unknown
- 2001-11-28 NO NO20015808A patent/NO20015808L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1183071A1 (en) | 2002-03-06 |
| KR20020023947A (en) | 2002-03-29 |
| IL146816A0 (en) | 2002-07-25 |
| AU5094500A (en) | 2000-12-28 |
| ZA200109721B (en) | 2002-09-25 |
| WO2000074781A1 (en) | 2000-12-14 |
| MXPA01012416A (en) | 2005-04-19 |
| GB9912998D0 (en) | 1999-08-04 |
| BR0012108A (en) | 2002-07-02 |
| NO20015808L (en) | 2002-01-21 |
| NO20015808D0 (en) | 2001-11-28 |
| JP2003501168A (en) | 2003-01-14 |
| CN1353620A (en) | 2002-06-12 |
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| FZDE | Discontinued |