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CA2370760A1 - Peptides lineaires actifs au plan immunobiologique: methode amelioree d'identification et de localisation - Google Patents

Peptides lineaires actifs au plan immunobiologique: methode amelioree d'identification et de localisation Download PDF

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Publication number
CA2370760A1
CA2370760A1 CA002370760A CA2370760A CA2370760A1 CA 2370760 A1 CA2370760 A1 CA 2370760A1 CA 002370760 A CA002370760 A CA 002370760A CA 2370760 A CA2370760 A CA 2370760A CA 2370760 A1 CA2370760 A1 CA 2370760A1
Authority
CA
Canada
Prior art keywords
epitope
amino acid
epitopes
potential
acid residues
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002370760A
Other languages
English (en)
Inventor
William J. Kokolus
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/552,461 external-priority patent/US6780598B1/en
Application filed by Individual filed Critical Individual
Publication of CA2370760A1 publication Critical patent/CA2370760A1/fr
Abandoned legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6878—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids in eptitope analysis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Cette invention concerne l'identification d'épitopes protéiniques, plus particulièrement une nouvelle méthode d'identification et de détermination de l'emplacement, de la longueur optimale de résidus d'acides aminés et du pouvoir immunobiologique d'épitopes protéiniques. Cette méthode consiste reporter des valeurs d'hydrophilie et/ou d'hydrophobie sur une courbe continue obtenue mathématiquement, ce qui permet de générer au moins un jeu d'épitopes potentiels qui renferment des épitopes potentiels classés comportant un nombre défini de résidus d'acides aminés. On présume que Les peptides linéaires actifs au plan immunobiologique sont des épitopes potentiels dont le positionnement présente l'alternance la plus marquée par rapport à une position d'équilibre lorsqu'ils sont juxtaposés sur le graphique d'hydrophilie et/ou d'hydrophobie et que leur longueur optimale correspond au nombre spécifique de résidus d'acides aminés dans le jeu d'épitopes potentiels classés. La séquence d'acides aminés des épitopes protéiniques selon l'invention présente un motif hydrophobique-hydrophilique-hydrophobique.
CA002370760A 1999-04-20 2000-04-19 Peptides lineaires actifs au plan immunobiologique: methode amelioree d'identification et de localisation Abandoned CA2370760A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US13023099P 1999-04-20 1999-04-20
US60/130,230 1999-04-20
US09/552,461 US6780598B1 (en) 1997-06-13 2000-04-18 Method of identifying and locating immunobiologically-active linear peptides
US09/552,461 2000-04-18
PCT/US2000/010585 WO2000063693A1 (fr) 1999-04-20 2000-04-19 Peptides lineaires actifs au plan immunobiologique: methode amelioree d'identification et de localisation

Publications (1)

Publication Number Publication Date
CA2370760A1 true CA2370760A1 (fr) 2000-10-26

Family

ID=26828276

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002370760A Abandoned CA2370760A1 (fr) 1999-04-20 2000-04-19 Peptides lineaires actifs au plan immunobiologique: methode amelioree d'identification et de localisation

Country Status (4)

Country Link
EP (1) EP1179178A1 (fr)
AU (1) AU4648900A (fr)
CA (1) CA2370760A1 (fr)
WO (1) WO2000063693A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7582299B2 (en) 2001-04-26 2009-09-01 Biogen Idec Ma Inc. Cripto-specific antibodies
PT1390389E (pt) * 2001-04-26 2009-04-03 Biogen Idec Inc Anticorpos que bloqueiam o cripto e as utilizações dos mesmos
AU2002950183A0 (en) * 2002-07-12 2002-09-12 The Council Of The Queensland Institute Of Medical Research Expression of hydrophobic proteins
CA2593212A1 (fr) 2005-01-05 2006-07-13 Biogen Idec Ma Inc. Molecules a liaison cripto

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4554101A (en) * 1981-01-09 1985-11-19 New York Blood Center, Inc. Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity

Also Published As

Publication number Publication date
AU4648900A (en) 2000-11-02
WO2000063693A1 (fr) 2000-10-26
EP1179178A1 (fr) 2002-02-13

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Legal Events

Date Code Title Description
FZDE Discontinued