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CA2361285A1 - Propanoic acid derivatives that inhibit the binding of integrins to their receptors - Google Patents

Propanoic acid derivatives that inhibit the binding of integrins to their receptors Download PDF

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Publication number
CA2361285A1
CA2361285A1 CA002361285A CA2361285A CA2361285A1 CA 2361285 A1 CA2361285 A1 CA 2361285A1 CA 002361285 A CA002361285 A CA 002361285A CA 2361285 A CA2361285 A CA 2361285A CA 2361285 A1 CA2361285 A1 CA 2361285A1
Authority
CA
Canada
Prior art keywords
binding
receptors
inhibit
integrins
acid derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002361285A
Other languages
French (fr)
Other versions
CA2361285C (en
Inventor
Ronald J. Biediger
George W. Holland
Jamal M. Kassir
Wen Li
Robert V. Market
Ian L. Scott
Chengde Wu
Brian Dupre
Linda K. Hamaker
Noel Nguyen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Encysive Pharmaceuticals Inc
Original Assignee
Texas Biotechnology Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/973,414 external-priority patent/US6723711B2/en
Application filed by Texas Biotechnology Corp filed Critical Texas Biotechnology Corp
Publication of CA2361285A1 publication Critical patent/CA2361285A1/en
Application granted granted Critical
Publication of CA2361285C publication Critical patent/CA2361285C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

A method for the inhibition of the binding of .alpha.4.beta.1 integrin to its receptors, for example VCAM-1 (vascular cell adhesion molecule-1) and fibronectin; compounds that inhibit this binding; pharmaceutically active compositions comprising such compounds; and the use of such compounds either as above, or in formulations for the control or prevention of diseases states in which .alpha.4.beta.1 is involved.
CA002361285A 2001-10-09 2001-11-07 Propanoic acid derivatives that inhibit the binding of integrins to their receptors Expired - Fee Related CA2361285C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/973,414 US6723711B2 (en) 1999-05-07 2001-10-09 Propanoic acid derivatives that inhibit the binding of integrins to their receptors
US09/973,414 2001-10-09

Publications (2)

Publication Number Publication Date
CA2361285A1 true CA2361285A1 (en) 2003-04-09
CA2361285C CA2361285C (en) 2009-10-27

Family

ID=25520865

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002361285A Expired - Fee Related CA2361285C (en) 2001-10-09 2001-11-07 Propanoic acid derivatives that inhibit the binding of integrins to their receptors

Country Status (2)

Country Link
AU (1) AU784156B2 (en)
CA (1) CA2361285C (en)

Also Published As

Publication number Publication date
CA2361285C (en) 2009-10-27
AU9708501A (en) 2002-02-07
AU784156B2 (en) 2006-02-09

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20161107