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CA2343123A1 - Active substance concentrate with formoterol, suitable for storage - Google Patents

Active substance concentrate with formoterol, suitable for storage Download PDF

Info

Publication number
CA2343123A1
CA2343123A1 CA002343123A CA2343123A CA2343123A1 CA 2343123 A1 CA2343123 A1 CA 2343123A1 CA 002343123 A CA002343123 A CA 002343123A CA 2343123 A CA2343123 A CA 2343123A CA 2343123 A1 CA2343123 A1 CA 2343123A1
Authority
CA
Canada
Prior art keywords
storage
active substance
formoterol
substance concentrate
concentrate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002343123A
Other languages
French (fr)
Other versions
CA2343123C (en
Inventor
Dieter Hochrainer
Bernd Zierenberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19847969A external-priority patent/DE19847969A1/en
Application filed by Individual filed Critical Individual
Publication of CA2343123A1 publication Critical patent/CA2343123A1/en
Application granted granted Critical
Publication of CA2343123C publication Critical patent/CA2343123C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to a formoterol active substance concentrate suitable for storage, in the form of a solution or suspension for use in inhalers for inhalation or nasal therapy.
CA002343123A 1998-10-17 1999-10-09 Active substance concentrate with formoterol, suitable for storage Expired - Fee Related CA2343123C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE19847969A DE19847969A1 (en) 1998-10-17 1998-10-17 Stable liquid formulation of formoterol in solution or suspension medium, used after dilution for treatment of asthma by inhalation
DE19847969.7 1998-10-17
US11238098P 1998-12-14 1998-12-14
US60/112,380 1998-12-14
PCT/EP1999/007581 WO2000023065A2 (en) 1998-10-17 1999-10-09 Storable active substance concentrate with formoterol

Publications (2)

Publication Number Publication Date
CA2343123A1 true CA2343123A1 (en) 2000-04-27
CA2343123C CA2343123C (en) 2008-03-25

Family

ID=26049594

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002343123A Expired - Fee Related CA2343123C (en) 1998-10-17 1999-10-09 Active substance concentrate with formoterol, suitable for storage

Country Status (26)

Country Link
EP (1) EP1121112B1 (en)
JP (2) JP3636430B2 (en)
KR (1) KR100655100B1 (en)
CN (1) CN1187044C (en)
BG (1) BG65350B1 (en)
BR (1) BR9914507A (en)
CA (1) CA2343123C (en)
CZ (1) CZ20011362A3 (en)
DE (1) DE59901669D1 (en)
DK (1) DK1121112T3 (en)
EA (1) EA003960B1 (en)
EE (1) EE04219B1 (en)
ES (1) ES2178479T3 (en)
HK (1) HK1041448B (en)
HR (1) HRP20010255A2 (en)
HU (1) HUP0103925A3 (en)
ID (1) ID29605A (en)
IL (2) IL142494A0 (en)
NO (1) NO20011663D0 (en)
NZ (1) NZ511225A (en)
PL (1) PL348434A1 (en)
PT (1) PT1121112E (en)
SI (1) SI1121112T1 (en)
SK (1) SK285382B6 (en)
TR (1) TR200101096T2 (en)
WO (1) WO2000023065A2 (en)

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007059620A1 (en) * 2005-11-23 2007-05-31 Feanny Stephen J Method for administering formoterol using a nebulizer
US9545487B2 (en) 2012-04-13 2017-01-17 Boehringer Ingelheim International Gmbh Dispenser with encoding means
US9682202B2 (en) 2009-05-18 2017-06-20 Boehringer Ingelheim International Gmbh Adapter, inhalation device, and atomizer
US9724482B2 (en) 2009-11-25 2017-08-08 Boehringer Ingelheim International Gmbh Nebulizer
US9744313B2 (en) 2013-08-09 2017-08-29 Boehringer Ingelheim International Gmbh Nebulizer
US9757750B2 (en) 2011-04-01 2017-09-12 Boehringer Ingelheim International Gmbh Medicinal device with container
US9827384B2 (en) 2011-05-23 2017-11-28 Boehringer Ingelheim International Gmbh Nebulizer
US9943654B2 (en) 2010-06-24 2018-04-17 Boehringer Ingelheim International Gmbh Nebulizer
US10004857B2 (en) 2013-08-09 2018-06-26 Boehringer Ingelheim International Gmbh Nebulizer
US10011906B2 (en) 2009-03-31 2018-07-03 Beohringer Ingelheim International Gmbh Method for coating a surface of a component
US10016568B2 (en) 2009-11-25 2018-07-10 Boehringer Ingelheim International Gmbh Nebulizer
US10099022B2 (en) 2014-05-07 2018-10-16 Boehringer Ingelheim International Gmbh Nebulizer
US10124125B2 (en) 2009-11-25 2018-11-13 Boehringer Ingelheim International Gmbh Nebulizer
US10124129B2 (en) 2008-01-02 2018-11-13 Boehringer Ingelheim International Gmbh Dispensing device, storage device and method for dispensing a formulation
US10195374B2 (en) 2014-05-07 2019-02-05 Boehringer Ingelheim International Gmbh Container, nebulizer and use
US10722666B2 (en) 2014-05-07 2020-07-28 Boehringer Ingelheim International Gmbh Nebulizer with axially movable and lockable container and indicator

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010031244A1 (en) 1997-06-13 2001-10-18 Chiesi Farmaceutici S.P.A. Pharmaceutical aerosol composition
DZ2947A1 (en) 1998-11-25 2004-03-15 Chiesi Farma Spa Pressure metered dose inhaler.
IT1313553B1 (en) 1999-07-23 2002-09-09 Chiesi Farma Spa OPTIMIZED FORMULATIONS CONSTITUTED BY SOLUTIONS OF STEROIDS GIVEN BY INHALATION.
IT1317846B1 (en) 2000-02-22 2003-07-15 Chiesi Farma Spa FORMULATIONS CONTAINING AN ANTICOLINERGIC DRUG FOR THE TREATMENT OF CHRONIC OBSTRUCTIVE BRONCOPNEUMOPATHY.
MXPA02011414A (en) * 2000-05-22 2003-06-06 Chiesi Farma Spa Stable pharmaceutical solution formulations for pressurised metered dose inhalers.
US6667344B2 (en) * 2001-04-17 2003-12-23 Dey, L.P. Bronchodilating compositions and methods
US20030055026A1 (en) 2001-04-17 2003-03-20 Dey L.P. Formoterol/steroid bronchodilating compositions and methods of use thereof
TWI359675B (en) 2003-07-10 2012-03-11 Dey L P Bronchodilating β-agonist compositions
EP1595531A1 (en) 2004-05-13 2005-11-16 CHIESI FARMACEUTICI S.p.A. Stable pharmaceutical solution formulations for pressurized metered dose inhalers
ITRM20040268A1 (en) * 2004-05-31 2004-08-31 Italchimici S P A PHARMACEUTICAL FORMULATION OF A STABLE FORMOTEROL SOLUTION BY INHALATION AND ON ITS PREPARATION.
ITRM20050022A1 (en) 2005-01-19 2006-07-20 Italchimici S P A PHARMACEUTICAL FORMULATION OF A STABLE SOLUTION OF PROPYLENE GLYCOL CONTAINING FORMOTEROL BY INHALATION AND ITS PREPARATION PROCEDURE.
DE102006023756A1 (en) * 2006-05-20 2007-11-29 Boehringer Ingelheim Pharma Gmbh & Co. Kg Ethanol-containing aerosol formulation for inhalation
CA2653744C (en) * 2006-05-26 2018-01-16 Dey, L.P. Nebulizable compositions of quaternary ammonium muscarinic receptor antagonists
CN107362140A (en) * 2016-05-11 2017-11-21 广东东阳光药业有限公司 Sprays and Spray Components
CN111936124A (en) * 2018-07-26 2020-11-13 四川海思科制药有限公司 Aerosol pharmaceutical composition containing glycopyrronium salt and indacaterol salt, and preparation method and application thereof
CN110755414A (en) * 2019-11-12 2020-02-07 南京华盖制药有限公司 Arformoterol tartrate aerosol and preparation method thereof
MX2023001201A (en) * 2020-07-31 2023-05-03 Chemo Res S L Combination therapy for inhalation administration.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE204743T1 (en) * 1991-12-18 2001-09-15 Minnesota Mining & Mfg AEROSOL COMPOSITIONS FOR MEDICINAL SUSPENSIONS
GB9612297D0 (en) * 1996-06-11 1996-08-14 Minnesota Mining & Mfg Medicinal aerosol formulations
GB9616237D0 (en) * 1996-08-01 1996-09-11 Norton Healthcare Ltd Aerosol formulations

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007059620A1 (en) * 2005-11-23 2007-05-31 Feanny Stephen J Method for administering formoterol using a nebulizer
US10124129B2 (en) 2008-01-02 2018-11-13 Boehringer Ingelheim International Gmbh Dispensing device, storage device and method for dispensing a formulation
US10011906B2 (en) 2009-03-31 2018-07-03 Beohringer Ingelheim International Gmbh Method for coating a surface of a component
US9682202B2 (en) 2009-05-18 2017-06-20 Boehringer Ingelheim International Gmbh Adapter, inhalation device, and atomizer
US9724482B2 (en) 2009-11-25 2017-08-08 Boehringer Ingelheim International Gmbh Nebulizer
US10124125B2 (en) 2009-11-25 2018-11-13 Boehringer Ingelheim International Gmbh Nebulizer
US10016568B2 (en) 2009-11-25 2018-07-10 Boehringer Ingelheim International Gmbh Nebulizer
US9943654B2 (en) 2010-06-24 2018-04-17 Boehringer Ingelheim International Gmbh Nebulizer
US9757750B2 (en) 2011-04-01 2017-09-12 Boehringer Ingelheim International Gmbh Medicinal device with container
US9827384B2 (en) 2011-05-23 2017-11-28 Boehringer Ingelheim International Gmbh Nebulizer
US9545487B2 (en) 2012-04-13 2017-01-17 Boehringer Ingelheim International Gmbh Dispenser with encoding means
US10220163B2 (en) 2012-04-13 2019-03-05 Boehringer Ingelheim International Gmbh Nebuliser with coding means
US10004857B2 (en) 2013-08-09 2018-06-26 Boehringer Ingelheim International Gmbh Nebulizer
US9744313B2 (en) 2013-08-09 2017-08-29 Boehringer Ingelheim International Gmbh Nebulizer
US10894134B2 (en) 2013-08-09 2021-01-19 Boehringer Ingelheim International Gmbh Nebulizer
US11642476B2 (en) 2013-08-09 2023-05-09 Boehringer Ingelheim International Gmbh Nebulizer
US10716905B2 (en) 2014-02-23 2020-07-21 Boehringer Lngelheim International Gmbh Container, nebulizer and use
US10099022B2 (en) 2014-05-07 2018-10-16 Boehringer Ingelheim International Gmbh Nebulizer
US10195374B2 (en) 2014-05-07 2019-02-05 Boehringer Ingelheim International Gmbh Container, nebulizer and use
US10722666B2 (en) 2014-05-07 2020-07-28 Boehringer Ingelheim International Gmbh Nebulizer with axially movable and lockable container and indicator

Also Published As

Publication number Publication date
IL142494A (en) 2006-04-10
WO2000023065A2 (en) 2000-04-27
CA2343123C (en) 2008-03-25
DE59901669D1 (en) 2002-07-11
ID29605A (en) 2001-09-06
HK1041448B (en) 2005-05-13
WO2000023065A3 (en) 2000-08-03
NO20011663L (en) 2001-04-03
IL142494A0 (en) 2002-03-10
HRP20010255A2 (en) 2002-04-30
EA200100439A1 (en) 2001-10-22
BG105391A (en) 2001-11-30
WO2000023065A8 (en) 2001-02-22
EE04219B1 (en) 2004-02-16
JP2005047933A (en) 2005-02-24
CN1333682A (en) 2002-01-30
DK1121112T3 (en) 2002-09-16
KR20010075637A (en) 2001-08-09
BR9914507A (en) 2001-06-26
EP1121112B1 (en) 2002-06-05
NO20011663D0 (en) 2001-04-03
JP2002527473A (en) 2002-08-27
HK1041448A1 (en) 2002-07-12
KR100655100B1 (en) 2006-12-08
NZ511225A (en) 2003-08-29
EE200100224A (en) 2002-06-17
HUP0103925A2 (en) 2002-05-29
HUP0103925A3 (en) 2003-05-28
CZ20011362A3 (en) 2001-09-12
SI1121112T1 (en) 2002-10-31
TR200101096T2 (en) 2001-12-21
EA003960B1 (en) 2003-10-30
PT1121112E (en) 2002-11-29
PL348434A1 (en) 2002-05-20
BG65350B1 (en) 2008-03-31
ES2178479T3 (en) 2002-12-16
SK4942001A3 (en) 2001-09-11
CN1187044C (en) 2005-02-02
JP3636430B2 (en) 2005-04-06
SK285382B6 (en) 2006-12-07
EP1121112A2 (en) 2001-08-08

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