CA2325055A1 - Vaccins contenant de la piline de recombinaison utilises contre les maladies provoquees par neisseria gonorrhoeae ou neisseria meningitidis - Google Patents
Vaccins contenant de la piline de recombinaison utilises contre les maladies provoquees par neisseria gonorrhoeae ou neisseria meningitidis Download PDFInfo
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- CA2325055A1 CA2325055A1 CA002325055A CA2325055A CA2325055A1 CA 2325055 A1 CA2325055 A1 CA 2325055A1 CA 002325055 A CA002325055 A CA 002325055A CA 2325055 A CA2325055 A CA 2325055A CA 2325055 A1 CA2325055 A1 CA 2325055A1
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- rpilin
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- MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Communicable Diseases (AREA)
- Plant Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Les gènes pilE de chacun de Neisseria gonorrhoeae et de Neisseria meningitidis sont clonés et leurs protéines piline de recombinaison correspondantes sont exprimées. En outre, un gène chimère pilE est construit dans lequel la région du gène pilE de Neisseria meningitidis de classe I codant la région N-terminale de la protéine piline est remplacée par la région correspondante du gène pilE de Neisseria gonorrhoeae. La protéine piline de classe I chimère méningococcique de recombinaison est exprimée à des taux supérieurs à la protéine piline exprimée par le gène pilE complet de Neisseria meningitidis. De surcroît un gène chimère pilE est construit dans lequel la région du gène pilE de Neisseria meningitidis de classe II codant la région C-terminale de la protéine piline est remplacée par la région correspondante du gène pilE de Neisseria gonorrhoeae. Les protéines piline de recombinaison sont utilisées dans des vaccins destinés à protéger contre les maladies provoquées par Neisseria gonorrhoeae ou Neisseria meningitidis.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8340598P | 1998-04-29 | 1998-04-29 | |
| US60/083,405 | 1998-04-29 | ||
| PCT/US1999/009486 WO1999055875A2 (fr) | 1998-04-29 | 1999-04-29 | VACCINS CONTENANT DE LA PILINE DE RECOMBINAISON UTILISES CONTRE LES MALADIES PROVOQUEES PAR NEISSERIA GONORRHOEAE OU $i(NEISSERIA MENINGITIDIS) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2325055A1 true CA2325055A1 (fr) | 1999-11-04 |
Family
ID=22178094
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002325055A Abandoned CA2325055A1 (fr) | 1998-04-29 | 1999-04-29 | Vaccins contenant de la piline de recombinaison utilises contre les maladies provoquees par neisseria gonorrhoeae ou neisseria meningitidis |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1073748A2 (fr) |
| JP (1) | JP2002527041A (fr) |
| KR (4) | KR20060118630A (fr) |
| CN (1) | CN1245512C (fr) |
| AU (2) | AU3968599A (fr) |
| BR (1) | BR9910005A (fr) |
| CA (1) | CA2325055A1 (fr) |
| IL (1) | IL139311A0 (fr) |
| WO (1) | WO1999055875A2 (fr) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0011108D0 (en) * | 2000-05-08 | 2000-06-28 | Microscience Ltd | Virulence gene and protein and their use |
| GB0118249D0 (en) * | 2001-07-26 | 2001-09-19 | Chiron Spa | Histidine vaccines |
| DE602005025617D1 (de) * | 2004-04-08 | 2011-02-10 | State Of Queensland Acting Through Queensland Health Brisbane | Nachweis von neisseria gonorrhoeae |
| US20110182981A1 (en) * | 2008-08-25 | 2011-07-28 | Peixuan Zhu | Gonococcal vaccines |
| US9802988B2 (en) * | 2009-05-20 | 2017-10-31 | University Of Maryland, Baltimore | Engineered type IV pilin of Clostridium difficile |
| EP2635593B1 (fr) * | 2010-11-05 | 2016-09-14 | Institut National de la Sante et de la Recherche Medicale (INSERM) | Vaccins pour la prévention d'infections à méningocoque |
| JP5991740B2 (ja) * | 2012-06-21 | 2016-09-14 | キヤノン株式会社 | ライセンス管理装置、ライセンス管理方法、およびプログラム |
| US10000545B2 (en) | 2012-07-27 | 2018-06-19 | Institut National De La Sante Et De La Recherche Medicale | CD147 as receptor for pilus-mediated adhesion of Meningococci to vascular endothelia |
| CN103405760A (zh) * | 2013-06-19 | 2013-11-27 | 中国科学院海洋研究所 | 迟缓爱德华氏菌菌毛蛋白FimA的应用 |
| CN106290849A (zh) * | 2015-05-13 | 2017-01-04 | 上海凯创生物技术有限公司 | 一种脑膜炎菌胶体金检测试剂盒 |
| CN118994336B (zh) * | 2024-10-22 | 2025-01-24 | 四川大学华西医院 | 鲍曼不动杆菌菌毛重组蛋白抗原、制备方法及其应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES447313A1 (es) * | 1975-04-25 | 1977-10-16 | Bactex Inc | Un procedimiento de aislamiento de pilos de n. gonorrhoeae. |
| EP0049945A3 (fr) * | 1980-09-15 | 1982-12-01 | Bactex Incorporated | Méthode pour la détermination de la hiérarchie des organismes piliés et vaccin préparé à partir de ces organismes |
| US4443431A (en) * | 1981-05-27 | 1984-04-17 | The United States Of America As Represented By The Department Of Health And Human Services | Neisseria gonorrhoeae vaccine |
| AU582358B2 (en) * | 1984-04-06 | 1989-03-23 | Scripps Clinic And Research Foundation | A peptide vaccine or diagnostic, and a polypeptide useful therefor |
| CU22302A1 (es) * | 1990-09-07 | 1995-01-31 | Cigb | Secuencia nucleotidica codificante para una proteina de la membrana externa de neisseria meningitidis y uso de dicha proteina en preparados vacunales |
| WO1992013871A1 (fr) * | 1991-01-31 | 1992-08-20 | Washington University | Polypeptides et polynucleotides utiles pour le diagnostic et le traitement de neisseria pathogene |
| WO1993011791A1 (fr) * | 1991-12-18 | 1993-06-24 | The State Of Oregon Acting By And Through The Oregon State Board Of Higher Education On Behalf Of Oregon State University | Preparations antigeniques destinees a stimuler la production d'anticorps se liant au poils des bacteries a poils |
| PT761231E (pt) * | 1992-06-25 | 2000-06-30 | Smithkline Beecham Biolog | Composicao de vacina contendo adjuvantes |
| AU5403594A (en) * | 1992-10-07 | 1994-04-26 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University | Pilin variants and uses thereof |
| US6265567B1 (en) * | 1995-04-07 | 2001-07-24 | University Of North Carolina At Chapel Hill | Isolated FrpB nucleic acid molecule |
-
1999
- 1999-04-29 AU AU39685/99A patent/AU3968599A/en not_active Abandoned
- 1999-04-29 KR KR1020067022731A patent/KR20060118630A/ko not_active Ceased
- 1999-04-29 BR BR9910005-3A patent/BR9910005A/pt not_active IP Right Cessation
- 1999-04-29 CN CNB998056014A patent/CN1245512C/zh not_active Expired - Fee Related
- 1999-04-29 IL IL13931199A patent/IL139311A0/xx unknown
- 1999-04-29 KR KR1020007011991A patent/KR20010043105A/ko not_active Ceased
- 1999-04-29 KR KR1020067022726A patent/KR20060118628A/ko not_active Ceased
- 1999-04-29 CA CA002325055A patent/CA2325055A1/fr not_active Abandoned
- 1999-04-29 KR KR1020067022728A patent/KR20060118629A/ko not_active Ceased
- 1999-04-29 EP EP99922760A patent/EP1073748A2/fr not_active Withdrawn
- 1999-04-29 JP JP2000546019A patent/JP2002527041A/ja not_active Withdrawn
- 1999-04-29 WO PCT/US1999/009486 patent/WO1999055875A2/fr active Application Filing
-
2003
- 2003-06-16 AU AU2003204738A patent/AU2003204738B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP1073748A2 (fr) | 2001-02-07 |
| AU2003204738B2 (en) | 2006-09-14 |
| WO1999055875A3 (fr) | 2000-04-13 |
| WO1999055875A2 (fr) | 1999-11-04 |
| KR20060118629A (ko) | 2006-11-23 |
| KR20060118628A (ko) | 2006-11-23 |
| CN1245512C (zh) | 2006-03-15 |
| IL139311A0 (en) | 2001-11-25 |
| KR20010043105A (ko) | 2001-05-25 |
| BR9910005A (pt) | 2001-01-16 |
| JP2002527041A (ja) | 2002-08-27 |
| CN1298446A (zh) | 2001-06-06 |
| AU3968599A (en) | 1999-11-16 |
| KR20060118630A (ko) | 2006-11-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |