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CA2305394A1 - Apport local d'inhibiteurs de phosphodiesterases, dans le traitement du dysfonctionnement erectile - Google Patents

Apport local d'inhibiteurs de phosphodiesterases, dans le traitement du dysfonctionnement erectile Download PDF

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Publication number
CA2305394A1
CA2305394A1 CA002305394A CA2305394A CA2305394A1 CA 2305394 A1 CA2305394 A1 CA 2305394A1 CA 002305394 A CA002305394 A CA 002305394A CA 2305394 A CA2305394 A CA 2305394A CA 2305394 A1 CA2305394 A1 CA 2305394A1
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CA
Canada
Prior art keywords
erectile dysfunction
local administration
treatment
phosphodiesterase inhibitors
administration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002305394A
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English (en)
Other versions
CA2305394C (fr
Inventor
Paul C. Doherty, Jr.
Virgil A. Place
William L. Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vivus LLC
Original Assignee
Individual
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Filing date
Publication date
Priority claimed from US09/181,070 external-priority patent/US6037346A/en
Application filed by Individual filed Critical Individual
Publication of CA2305394A1 publication Critical patent/CA2305394A1/fr
Application granted granted Critical
Publication of CA2305394C publication Critical patent/CA2305394C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
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    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence

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  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
CA002305394A 1997-10-28 1998-10-28 Apport local d'inhibiteurs de phosphodiesterases, dans le traitement du dysfonctionnement erectile Expired - Lifetime CA2305394C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US95881697A 1997-10-28 1997-10-28
US08/958,816 1997-10-28
US09/181,070 1998-10-27
US09/181,070 US6037346A (en) 1997-10-28 1998-10-27 Local administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction
PCT/US1998/022928 WO1999021558A2 (fr) 1997-10-28 1998-10-28 Apport local d'inhibiteurs de phosphodiesterases, dans le traitement du dysfonctionnement erectile

Publications (2)

Publication Number Publication Date
CA2305394A1 true CA2305394A1 (fr) 1999-05-06
CA2305394C CA2305394C (fr) 2006-12-12

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CA002305394A Expired - Lifetime CA2305394C (fr) 1997-10-28 1998-10-28 Apport local d'inhibiteurs de phosphodiesterases, dans le traitement du dysfonctionnement erectile

Country Status (5)

Country Link
EP (1) EP1027054A4 (fr)
JP (1) JP2003525845A (fr)
AU (1) AU734734B2 (fr)
CA (1) CA2305394C (fr)
WO (1) WO1999021558A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009000798A1 (fr) * 2007-06-26 2008-12-31 Solvay Pharmaceuticals B.V. N-oxyde de sildénafil comme promédicament

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6331543B1 (en) 1996-11-01 2001-12-18 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use
CA2295595A1 (fr) 1997-07-09 1999-01-21 Androsolutions, Inc. Compositions et procedes perfectionnes de traitement des troubles de l'erection chez l'homme
US6103765A (en) 1997-07-09 2000-08-15 Androsolutions, Inc. Methods for treating male erectile dysfunction
US6548490B1 (en) * 1997-10-28 2003-04-15 Vivus, Inc. Transmucosal administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction
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CA2305394C (fr) 2006-12-12
AU1125499A (en) 1999-05-17
EP1027054A4 (fr) 2002-11-04
WO1999021558A2 (fr) 1999-05-06
WO1999021558A3 (fr) 2000-10-26

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